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  • 1
    Publication Date: 2016-07-21
    Description: In most unconventional superconductors, the importance of antiferromagnetic fluctuations is widely acknowledged. In addition, cuprate and iron-pnictide high-temperature superconductors often exhibit unidirectional (nematic) electronic correlations, including stripe and orbital orders, whose fluctuations may also play a key role for electron pairing. In these materials, however, such nematic correlations are intertwined...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 2
    Publication Date: 2015-04-03
    Description: Chemical Reviews DOI: 10.1021/cr500689b
    Print ISSN: 0009-2665
    Electronic ISSN: 1520-6890
    Topics: Chemistry and Pharmacology
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  • 3
    Publication Date: 2016-06-28
    Description: In order to understand the trigger mechanism of slow-moving landslides occurring in the early cold season from late autumn to winter, we investigated the effect of temperature on the shear strength of slip surface soils. Displacement-controlled and shear stress-controlled box shear experiments were performed on undisturbed slip-zone soils under residual strength conditions. Test results conducted at temperatures from 9 to 25 °C showed remarkable shear strength reductions with decreasing temperature. Creep-like slow shear displacements were induced by a decrease in temperature. These temperature-dependent shear behaviors are attributed to the rheological properties of hydrous smectite that dominantly compose the soil material along the failure surface. Our experimental results imply that ground temperature conditions influence slope instability, especially for shallow landslides occurring in smectite-bearing rock areas.
    Print ISSN: 0094-8276
    Electronic ISSN: 1944-8007
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 4
    Publication Date: 2014-01-17
    Description: Journal of the American Chemical Society DOI: 10.1021/ja4113462
    Print ISSN: 0002-7863
    Electronic ISSN: 1520-5126
    Topics: Chemistry and Pharmacology
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  • 5
    Publication Date: 2013-10-16
    Description: In vitro methods have enabled the rapid and efficient evolution of proteins and successful generation of novel and highly functional proteins. However, the available methods consider only globular proteins (e.g., antibodies, enzymes) and not membrane proteins despite the biological and pharmaceutical importance of the latter. In this study, we report...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 6
    Publication Date: 2014-02-01
    Description: Author(s): S. Matsuura, Y. Mitsumori, H. Kosaka, K. Edamatsu, K. Miyazaki, D. Kim, M. Nakayama, G. Oohata, H. Oka, H. Ajiki, and H. Ishihara We observed the antibound state, as well as the bound state, for cavity polariton pairs in a planar CuCl microcavity by spectrally resolved four-wave mixing. We obtained dispersion curves of the bound and antibound states by changing the incident angle of the pump pulses corresponding to the cavity ... [Phys. Rev. B 89, 035317] Published Fri Jan 31, 2014
    Keywords: Semiconductors II: surfaces, interfaces, microstructures, and related topics
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 7
    Publication Date: 2015-03-18
    Description: Vertebrates have a unique 3D body shape in which correct tissue and organ shape and alignment are essential for function. For example, vision requires the lens to be centred in the eye cup which must in turn be correctly positioned in the head. Tissue morphogenesis depends on force generation, force transmission through the tissue, and response of tissues and extracellular matrix to force. Although a century ago D'Arcy Thompson postulated that terrestrial animal body shapes are conditioned by gravity, there has been no animal model directly demonstrating how the aforementioned mechano-morphogenetic processes are coordinated to generate a body shape that withstands gravity. Here we report a unique medaka fish (Oryzias latipes) mutant, hirame (hir), which is sensitive to deformation by gravity. hir embryos display a markedly flattened body caused by mutation of YAP, a nuclear executor of Hippo signalling that regulates organ size. We show that actomyosin-mediated tissue tension is reduced in hir embryos, leading to tissue flattening and tissue misalignment, both of which contribute to body flattening. By analysing YAP function in 3D spheroids of human cells, we identify the Rho GTPase activating protein ARHGAP18 as an effector of YAP in controlling tissue tension. Together, these findings reveal a previously unrecognised function of YAP in regulating tissue shape and alignment required for proper 3D body shape. Understanding this morphogenetic function of YAP could facilitate the use of embryonic stem cells to generate complex organs requiring correct alignment of multiple tissues.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720436/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720436/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Porazinski, Sean -- Wang, Huijia -- Asaoka, Yoichi -- Behrndt, Martin -- Miyamoto, Tatsuo -- Morita, Hitoshi -- Hata, Shoji -- Sasaki, Takashi -- Krens, S F Gabriel -- Osada, Yumi -- Asaka, Satoshi -- Momoi, Akihiro -- Linton, Sarah -- Miesfeld, Joel B -- Link, Brian A -- Senga, Takeshi -- Castillo-Morales, Atahualpa -- Urrutia, Araxi O -- Shimizu, Nobuyoshi -- Nagase, Hideaki -- Matsuura, Shinya -- Bagby, Stefan -- Kondoh, Hisato -- Nishina, Hiroshi -- Heisenberg, Carl-Philipp -- Furutani-Seiki, Makoto -- P30 EY001931/EY/NEI NIH HHS/ -- R01 EY014167/EY/NEI NIH HHS/ -- R01 EY016060/EY/NEI NIH HHS/ -- R01EY014167/EY/NEI NIH HHS/ -- Medical Research Council/United Kingdom -- England -- Nature. 2015 May 14;521(7551):217-21. doi: 10.1038/nature14215. Epub 2015 Mar 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK. ; Department of Developmental and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, Japan. ; IST Austria, Am Campus 1, A-3400 Klosterneuburg, Austria. ; Department of Genetics and Cell Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan. ; Department of Molecular Biology, School of Medicine, Keio University, Tokyo 160-8582, Japan. ; Japan Science and Technology Agency (JST), ERATO-SORST Kondoh Differentiation Signaling Project, Kyoto 606-8305, Japan. ; Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA. ; Division of Cancer Biology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan. ; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7FY, UK. ; 1] Japan Science and Technology Agency (JST), ERATO-SORST Kondoh Differentiation Signaling Project, Kyoto 606-8305, Japan [2] Graduate School of Frontier Bioscience, Osaka University, Osaka 565-0871, Japan [3] Faculty of Life Sciences, Kyoto Sangyo University, Kyoto 603-8555, Japan. ; 1] Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK [2] Japan Science and Technology Agency (JST), ERATO-SORST Kondoh Differentiation Signaling Project, Kyoto 606-8305, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25778702" target="_blank"〉PubMed〈/a〉
    Keywords: Actomyosin/metabolism ; Adaptor Proteins, Signal Transducing/genetics/metabolism ; Animals ; Body Size/*genetics ; Embryo, Nonmammalian/anatomy & histology/embryology/metabolism ; Fish Proteins/genetics/*metabolism ; GTPase-Activating Proteins/metabolism ; Genes, Essential/genetics ; Gravitation ; Humans ; Morphogenesis/*genetics ; Mutation/genetics ; Organ Size/genetics ; Oryzias/*anatomy & histology/*embryology/genetics ; Phenotype ; Protein-Serine-Threonine Kinases/genetics/metabolism ; Signal Transduction ; Spheroids, Cellular/cytology/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2014-11-08
    Description: Extragalactic background light (EBL) anisotropy traces variations in the total production of photons over cosmic history and may contain faint, extended components missed in galaxy point-source surveys. Infrared EBL fluctuations have been attributed to primordial galaxies and black holes at the epoch of reionization (EOR) or, alternately, intrahalo light (IHL) from stars tidally stripped from their parent galaxies at low redshift. We report new EBL anisotropy measurements from a specialized sounding rocket experiment at 1.1 and 1.6 micrometers. The observed fluctuations exceed the amplitude from known galaxy populations, are inconsistent with EOR galaxies and black holes, and are largely explained by IHL emission. The measured fluctuations are associated with an EBL intensity that is comparable to the background from known galaxies measured through number counts and therefore a substantial contribution to the energy contained in photons in the cosmos.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zemcov, Michael -- Smidt, Joseph -- Arai, Toshiaki -- Bock, James -- Cooray, Asantha -- Gong, Yan -- Kim, Min Gyu -- Korngut, Phillip -- Lam, Anson -- Lee, Dae Hee -- Matsumoto, Toshio -- Matsuura, Shuji -- Nam, Uk Won -- Roudier, Gael -- Tsumura, Kohji -- Wada, Takehiko -- New York, N.Y. -- Science. 2014 Nov 7;346(6210):732-5. doi: 10.1126/science.1258168.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, Mathematics, and Astronomy, California Institute of Technology, Pasadena, CA 91125, USA. Jet Propulsion Laboratory (JPL), National Aeronautics and Space Administration (NASA), Pasadena, CA 91109, USA. ; Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA. Department of Physics and Astronomy, University of California, Irvine, CA 92697, USA. ; Department of Space Astronomy and Astrophysics, Institute of Space and Astronautical Science (ISAS), Japan Aerospace Exploration Agency (JAXA), Sagamihara, Kanagawa 252-5210, Japan. Department of Physics, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan. ; Department of Physics, Mathematics, and Astronomy, California Institute of Technology, Pasadena, CA 91125, USA. Jet Propulsion Laboratory (JPL), National Aeronautics and Space Administration (NASA), Pasadena, CA 91109, USA. jjb@astro.caltech.edu. ; Department of Physics and Astronomy, University of California, Irvine, CA 92697, USA. ; Department of Physics and Astronomy, Seoul National University, Seoul 151-742, Korea. ; Jet Propulsion Laboratory (JPL), National Aeronautics and Space Administration (NASA), Pasadena, CA 91109, USA. Department of Physics, Mathematics, and Astronomy, California Institute of Technology, Pasadena, CA 91125, USA. ; Department of Physics and Astronomy, University of California, Los Angeles, CA 90095, USA. Department of Physics, Mathematics, and Astronomy, California Institute of Technology, Pasadena, CA 91125, USA. ; Korea Astronomy and Space Science Institute (KASI), Daejeon 305-348, Korea. ; Department of Space Astronomy and Astrophysics, Institute of Space and Astronautical Science (ISAS), Japan Aerospace Exploration Agency (JAXA), Sagamihara, Kanagawa 252-5210, Japan. Institute of Astronomy and Astrophysics, Academia Sinica, Taipei 10617, Taiwan, Republic of China. ; Department of Space Astronomy and Astrophysics, Institute of Space and Astronautical Science (ISAS), Japan Aerospace Exploration Agency (JAXA), Sagamihara, Kanagawa 252-5210, Japan. ; Jet Propulsion Laboratory (JPL), National Aeronautics and Space Administration (NASA), Pasadena, CA 91109, USA. ; Frontier Research Institute for Interdisciplinary Science, Tohoku University, Sendai, Miyagi, 980-8578, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25378620" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
    Publication Date: 2016-04-08
    Description: Chloroflexus aggregans is an unbranched multicellular filamentous bacterium having the ability of gliding motility. The filament moves straightforward at a constant rate, ~3 μm sec –1 on solid surface and occasionally reverses the moving direction. In this study, we successfully detected movements of glass beads on the cell-surface along long axis of the filament indicating that the cell-surface movement was the direct force for gliding. Microscopic analyses found that the cell-surface movements were confined to a cell of the filament, and each cell independently moved and reversed the direction. To understand how the cellular movements determine the moving direction of the filament, we proposed a discrete-time stochastic model; sum of the directions of the cellular movements determines the moving direction of the filament only when the filament pauses, and after moving, the filament keeps the same directional movement until all the cells pause and/or move in the opposite direction. Monte Carlo simulation of this model showed that reversal frequency of longer filaments was relatively fixed to be low, but the frequency of shorter filaments varied widely. This simulation result appropriately explained the experimental observations. This study proposed the relevant mechanism adequately describing the motility of the multicellular filament in C. aggregans .
    Keywords: Physiology & Biochemistry
    Print ISSN: 0378-1097
    Electronic ISSN: 1574-6968
    Topics: Biology
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  • 10
    Publication Date: 2010-04-30
    Description: Amyotrophic lateral sclerosis (ALS) has its onset in middle age and is a progressive disorder characterized by degeneration of motor neurons of the primary motor cortex, brainstem and spinal cord. Most cases of ALS are sporadic, but about 10% are familial. Genes known to cause classic familial ALS (FALS) are superoxide dismutase 1 (SOD1), ANG encoding angiogenin, TARDP encoding transactive response (TAR) DNA-binding protein TDP-43 (ref. 4) and fused in sarcoma/translated in liposarcoma (FUS, also known as TLS). However, these genetic defects occur in only about 20-30% of cases of FALS, and most genes causing FALS are unknown. Here we show that there are mutations in the gene encoding optineurin (OPTN), earlier reported to be a causative gene of primary open-angle glaucoma (POAG), in patients with ALS. We found three types of mutation of OPTN: a homozygous deletion of exon 5, a homozygous Q398X nonsense mutation and a heterozygous E478G missense mutation within its ubiquitin-binding domain. Analysis of cell transfection showed that the nonsense and missense mutations of OPTN abolished the inhibition of activation of nuclear factor kappa B (NF-kappaB), and the E478G mutation revealed a cytoplasmic distribution different from that of the wild type or a POAG mutation. A case with the E478G mutation showed OPTN-immunoreactive cytoplasmic inclusions. Furthermore, TDP-43- or SOD1-positive inclusions of sporadic and SOD1 cases of ALS were also noticeably immunolabelled by anti-OPTN antibodies. Our findings strongly suggest that OPTN is involved in the pathogenesis of ALS. They also indicate that NF-kappaB inhibitors could be used to treat ALS and that transgenic mice bearing various mutations of OPTN will be relevant in developing new drugs for this disorder.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maruyama, Hirofumi -- Morino, Hiroyuki -- Ito, Hidefumi -- Izumi, Yuishin -- Kato, Hidemasa -- Watanabe, Yasuhito -- Kinoshita, Yoshimi -- Kamada, Masaki -- Nodera, Hiroyuki -- Suzuki, Hidenori -- Komure, Osamu -- Matsuura, Shinya -- Kobatake, Keitaro -- Morimoto, Nobutoshi -- Abe, Koji -- Suzuki, Naoki -- Aoki, Masashi -- Kawata, Akihiro -- Hirai, Takeshi -- Kato, Takeo -- Ogasawara, Kazumasa -- Hirano, Asao -- Takumi, Toru -- Kusaka, Hirofumi -- Hagiwara, Koichi -- Kaji, Ryuji -- Kawakami, Hideshi -- England -- Nature. 2010 May 13;465(7295):223-6. doi: 10.1038/nature08971. Epub 2010 Apr 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Epidemiology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20428114" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Amino Acid Sequence ; Amyotrophic Lateral Sclerosis/*genetics/metabolism/pathology/physiopathology ; Asian Continental Ancestry Group ; Base Sequence ; Child ; Codon, Nonsense/genetics ; Consanguinity ; Cytoplasm/metabolism/pathology ; DNA-Binding Proteins/metabolism ; Exons/genetics ; Female ; Humans ; Japan ; Male ; Middle Aged ; Mutant Proteins/analysis/chemistry/genetics/metabolism ; Mutation/*genetics ; Mutation, Missense/genetics ; NF-kappa B/agonists/antagonists & inhibitors/metabolism ; Pedigree ; Polymorphism, Single Nucleotide/genetics ; Protein Transport ; Sequence Deletion/genetics ; Superoxide Dismutase/metabolism ; Transcription Factor TFIIIA/analysis/chemistry/*genetics/metabolism ; Young Adult
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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