Publication Date:
2000-08-05
Description:
It has been assumed that the new members of the p53 protein family, p63 and p73, would have the same job as p53, namely, forcing cells to die if they or their DNA is damaged. Now, as Morrison and Kinoshita explain in their Perspective, one particular form of p73 has been found to be a survival factor rather than a death factor for sympathetic neurons during development (Pozniak et al.).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morrison, R S -- Kinoshita, Y -- New York, N.Y. -- Science. 2000 Jul 14;289(5477):257-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurological Surgery, University of Washington School of Medicine, Box 356470, Seattle, WA 98195-6470, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10917851" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Apoptosis
;
DNA-Binding Proteins/genetics/*physiology
;
Genes, Tumor Suppressor
;
Mice
;
Neurons/*physiology
;
Nuclear Proteins/genetics/*physiology
;
Sympathetic Nervous System/cytology/*growth & development/physiology
;
Tumor Suppressor Protein p53/genetics/physiology
;
Tumor Suppressor Proteins
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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