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  • 1
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    Epigenetic regulation of COL15A1 in smooth muscle cell replicative aging and atherosclerosis (2013)
    Oxford University Press
    Details
    Publication Date: 2013-11-28
    Description: Smooth muscle cell (SMC) proliferation is a hallmark of vascular injury and disease. Global hypomethylation occurs during SMC proliferation in culture and in vivo during neointimal formation. Regardless of the programmed or stochastic nature of hypomethylation, identifying these changes is important in understanding vascular disease, as maintenance of a cells' epigenetic profile is essential for maintaining cellular phenotype. Global hypomethylation of proliferating aortic SMCs and concomitant decrease of DNMT1 expression were identified in culture during passage. An epigenome screen identified regions of the genome that were hypomethylated during proliferation and a region containing Collagen, type XV, alpha 1 ( COL15A1 ) was selected by ‘genomic convergence’ for characterization. COL15A1 transcript and protein levels increased with passage-dependent decreases in DNA methylation and the transcript was sensitive to treatment with 5-Aza-2'-deoxycytidine, suggesting DNA methylation-mediated gene expression. Phenotypically, knockdown of COL15A1 increased SMC migration and decreased proliferation and Col15a1 expression was induced in an atherosclerotic lesion and localized to the atherosclerotic cap. A sequence variant in COL15A1 that is significantly associated with atherosclerosis (rs4142986, P = 0.017, OR = 1.434) was methylated and methylation of the risk allele correlated with decreased gene expression and increased atherosclerosis in human aorta. In summary, hypomethylation of COL15A1 occurs during SMC proliferation and the consequent increased gene expression may impact SMC phenotype and atherosclerosis formation. Hypomethylated genes, such as COL15A1 , provide evidence for concomitant epigenetic regulation and genetic susceptibility, and define a class of causal targets that sit at the intersection of genetic and epigenetic predisposition in the etiology of complex disease.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 2
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    Is face processing species-specific during the first year of life? (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-05-23
    Description: Between 6 and 10 months of age, the infant's ability to discriminate among native speech sounds improves, whereas the same ability to discriminate among foreign speech sounds decreases. Our study aimed to determine whether this perceptual narrowing is unique to language or might also apply to face processing. We tested discrimination of human and monkey faces by 6-month-olds, 9-month-olds, and adults, using the visual paired-comparison procedure. Only the youngest group showed discrimination between individuals of both species; older infants and adults only showed evidence of discrimination of their own species. These results suggest that the "perceptual narrowing" phenomenon may represent a more general change in neural networks involved in early cognition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pascalis, Olivier -- de Haan, Michelle -- Nelson, Charles A -- New York, N.Y. -- Science. 2002 May 17;296(5571):1321-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, The University of Sheffield, Sheffield S10 2TP, UK. o.pascalis@sheffield.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12016317" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Aging ; Animals ; Evoked Potentials ; *Face ; Female ; Humans ; Infant ; Macaca fascicularis ; Male ; *Pattern Recognition, Visual ; *Recognition (Psychology) ; Species Specificity ; Speech Perception
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Cognitive recovery in socially deprived young children: the Bucharest Early Intervention Project (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-12-22
    Description: In a randomized controlled trial, we compared abandoned children reared in institutions to abandoned children placed in institutions but then moved to foster care. Young children living in institutions were randomly assigned to continued institutional care or to placement in foster care, and their cognitive development was tracked through 54 months of age. The cognitive outcome of children who remained in the institution was markedly below that of never-institutionalized children and children taken out of the institution and placed into foster care. The improved cognitive outcomes we observed at 42 and 54 months were most marked for the youngest children placed in foster care. These results point to the negative sequelae of early institutionalization, suggest a possible sensitive period in cognitive development, and underscore the advantages of family placements for young abandoned children.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nelson, Charles A 3rd -- Zeanah, Charles H -- Fox, Nathan A -- Marshall, Peter J -- Smyke, Anna T -- Guthrie, Donald -- New York, N.Y. -- Science. 2007 Dec 21;318(5858):1937-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Harvard Medical School and Children's Hospital, Boston, MA 02215, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18096809" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; *Child Development ; Child Rearing ; Child Welfare ; *Child, Abandoned ; *Child, Institutionalized ; Child, Preschool ; *Cognition ; *Early Intervention (Education) ; Female ; *Foster Home Care ; Humans ; Infant ; Intelligence ; Male ; Orphanages ; *Psychosocial Deprivation ; Romania
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Development as a result of institutionalization [Neuroscience] (2012)
    National Academy of Sciences
    Details
    Publication Date: 2012-08-08
    Description: We used structural MRI and EEG to examine brain structure and function in typically developing children in Romania (n = 20), children exposed to institutional rearing (n = 29), and children previously exposed to institutional rearing but then randomized to a high-quality foster care intervention (n = 25). In so doing, we provide a unique evaluation of whether placement in an improved environment mitigates the effects of institutional rearing on neural structure, using data from the only existing randomized controlled trial of foster care for institutionalized children. Children enrolled in the Bucharest Early Intervention Project underwent a T1-weighted MRI protocol. Children with histories of institutional rearing had significantly smaller cortical gray matter volume than never-institutionalized children. Cortical white matter was no different for children placed in foster care than never-institutionalized children but was significantly smaller for children not randomized to foster care. We were also able to explain previously reported reductions in EEG α-power among institutionally reared children compared with children raised in families using these MRI data. As hypothesized, the association between institutionalization and EEG α-power was partially mediated by cortical white matter volume for children not randomized to foster care. The increase in white matter among children randomized to an improved rearing environment relative to children who remained in institutional care suggests the potential for developmental “catch up” in white matter growth, even following extreme environmental deprivation.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 5
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    Asymmetry in facial expression (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nelson, C A -- Horowitz, F D -- New York, N.Y. -- Science. 1980 Aug 15;209(4458):834.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7403852" target="_blank"〉PubMed〈/a〉
    Keywords: Anthropometry ; Emotions ; *Facial Expression ; Female ; *Functional Laterality ; Humans ; Male
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Germline organization of the murine T cell receptor beta-chain genes (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-10-23
    Description: The complete germline organization of the beta-chain genes of the murine T cell receptor was elucidated in order to obtain the structural basis for understanding the mechanisms of somatic DNA rearrangements. Twenty of the 22 known variable (V beta) genes are clustered within 250 kilobases of DNA 5' to the constant region (C beta) genes. These V beta genes share the same transcriptional orientation as the diversity (D beta), joining (J beta), and C beta genes, which implies that chromosomal deletion is the mechanism for most V beta to D beta-J beta rearrangements. Within this V beta cluster, the distance between the most proximal V beta gene and the D beta-J beta-C beta cluster is 320 kilobases, as determined by field-inversion gel electrophoresis. The large distance between V beta and D beta, relative to that between D beta and J beta, may have significant implications for the ordered rearrangement of the T cell receptor beta-chain genes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chou, H S -- Nelson, C A -- Godambe, S A -- Chaplin, D D -- Loh, D Y -- GM07067/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1987 Oct 23;238(4826):545-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2821625" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Deletion ; Chromosome Mapping ; DNA/genetics ; DNA Restriction Enzymes ; Electrophoresis ; Macromolecular Substances ; Mice ; Mice, Inbred BALB C ; Mice, Mutant Strains ; Nucleic Acid Hybridization ; Receptors, Antigen, T-Cell/*genetics ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
    Electronic Resource
    Electronic Resource
    Direct detection of a microlens in the Milky Way (2001)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 414 (2001), S. 617-619 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The nature of dark matter remains mysterious, with luminous material accounting for at most ∼25 per cent of the baryons in the Universe. We accordingly undertook a survey looking for the microlensing of stars in the Large Magellanic Cloud (LMC) to determine the fraction of Galactic dark ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/414617a
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  • 8
    Electronic Resource
    Electronic Resource
    Three pion production on nuclei at 200 GeV (1983)
    Springer
    The European physical journal 16 (1983), S. 197-204 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We have carried out a systematic study of the coherent dissociation of pions into 3 pions using nuclear targets. The experiment was performed at Fermilab using a high resolution forward spectrometer. Data were taken with carbon, copper and lead targets at an incident momentum of 202.5 GeV/c. Results are presented on momentum transfers, 3-pion masses, and on the nuclearA-dependence of the production cross section.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01571606
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  • 9
    Electronic Resource
    Electronic Resource
    Experimental constraints onJ PC=1−+,I=1, Hybrid mesons (1986)
    Springer
    The European physical journal 31 (1986), S. 545-548 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Using data on coherent production of π+π+π- systems in π+ collisions with nuclei we exclude the existence ofJ PC=1−+,I=1, exotic hybrid mesons with masses below 1.5 GeV and widths greater than 20 MeV, provided that their primary coupling is to πρ systems. Hybrid states with just such properties have recently been predicted from arguments based on QCD sum rules. Our experimental limit is based on Primakoff production of these states, and on an argument using vector dominance to relate their radiative widths to πρ channels. There has been increasing interest of late in the existence of hybrid states, which, in the case of mesons, contain a valence gluon in addition to aq $$\bar q$$ pair in a color-octet state [1–5]. The pursuit of spectroscopic gluon degrees of freedom has been strongly motivated by the general QCD picture of hadrons, as well as by many specific calculations based on QCD sum rules, lattice simulations, and more phenomenological approaches such as QCD-bag models. Although much effort, both thoretical and experimental, has been devoted to the spectroscopy of glueballs, for which several candidates exist [6], it has also been realized that hybrid states may be as amenable to discovery, and perhaps less ambiguous to interpretation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01551075
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  • 10
    Electronic Resource
    Electronic Resource
    Coherent production of pairs of parabosons of order 2 (2005)
    Springer
    The European physical journal 39 (2005), S. 109-121 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. A parameter-free statistical model is used to study multiplicity signatures for coherent production of charged pairs of parabosons of order p = 2 in comparison with those arising in the case of ordinary bosons, p = 1. Two non-negative real parameters arise because “ab” and “ba” are fundamentally distinct pair operators of charge “ + 1”, A-quanta and charge “-1”, B-quanta parabosons. In 3D plots of ${P_{m}}(q)\equiv$ “the probability of m paraboson charged pairs + q positive parabosons” versus $\langle n\rangle $ and $\langle n^2\rangle $ , the p = 1 curve is found to lie on the relatively narrow 2D p = 2 surface.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1140/epjc/s2004-02067-0
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