ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Rabbits
  • Time Factors
  • American Association for the Advancement of Science (AAAS)  (340)
  • American Chemical Society
  • Oxford University Press
  • 2005-2009  (128)
  • 1980-1984  (212)
  • 1925-1929
Collection
Publisher
Years
Year
  • 1
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2006-04-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, Richard -- New York, N.Y. -- Science. 2006 Apr 14;312(5771):180-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16614186" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Chernobyl Nuclear Accident ; Food Contamination, Radioactive ; History, 20th Century ; Humans ; Neoplasms, Radiation-Induced/epidemiology ; Radiation Dosage ; Radiation Injuries/*epidemiology ; Radioactive Fallout/*adverse effects ; Republic of Belarus/epidemiology ; Russia/epidemiology ; Time Factors ; Ukraine/epidemiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 2
    Publication Date: 2006-10-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hansma, Paul K -- Schitter, Georg -- Fantner, Georg E -- Prater, Craig -- GM 65354/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2006 Oct 27;314(5799):601-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, University of California, Santa Barbara, CA 93106, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17068247" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Animals ; Collagen/ultrastructure ; Electronics ; *Microscopy, Atomic Force/instrumentation/methods ; Rats ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 3
    Publication Date: 2006-07-11
    Description: We investigated extraneural manifestations in scrapie-infected transgenic mice expressing prion protein lacking the glycophosphatydylinositol membrane anchor. In the brain, blood, and heart, both abnormal protease-resistant prion protein (PrPres) and prion infectivity were readily detected by immunoblot and by inoculation into nontransgenic recipients. The titer of infectious scrapie in blood plasma exceeded 10(7) 50% infectious doses per milliliter. The hearts of these transgenic mice contained PrPres-positive amyloid deposits that led to myocardial stiffness and cardiac disease.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1820586/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1820586/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Trifilo, Matthew J -- Yajima, Toshitaka -- Gu, Yusu -- Dalton, Nancy -- Peterson, Kirk L -- Race, Richard E -- Meade-White, Kimberly -- Portis, John L -- Masliah, Eliezer -- Knowlton, Kirk U -- Chesebro, Bruce -- Oldstone, Michael B A -- 5R01HL66424-04/HL/NHLBI NIH HHS/ -- AGO4342/PHS HHS/ -- NS041219-05/NS/NINDS NIH HHS/ -- P01 AG004342/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2006 Jul 7;313(5783):94-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Viral-Immunobiology Laboratory, Departments of Molecular and Integrative Neurosciences and Infectology, Scripps Research Institute, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16825571" target="_blank"〉PubMed〈/a〉
    Keywords: Amyloid/*analysis ; Amyloidosis/blood/etiology/*pathology/physiopathology ; Animals ; Blotting, Western ; Cardiac Catheterization ; Coronary Vessels/chemistry/pathology ; Disease Models, Animal ; Glycosylphosphatidylinositols ; Heart Diseases/blood/etiology/*pathology/physiopathology ; Heart Function Tests ; Immunohistochemistry ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Microcirculation/chemistry/pathology ; Myocardial Contraction ; Myocardium/*chemistry/*pathology ; PrPC Proteins/chemistry ; PrPSc Proteins/*analysis/blood ; Scrapie/blood/*pathology/physiopathology ; Staining and Labeling ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 4
    Publication Date: 2006-01-10
    Description: It is currently unclear whether observed pelagic ecosystem responses to ocean warming, such as a mid-1970s change in the eastern North Pacific, depart from typical ocean variability. We report variations in planktonic foraminifera from varved sediments off southern California spanning the past 1400 years. Increasing abundances of tropical/subtropical species throughout the 20th century reflect a warming trend superimposed on decadal-scale fluctuations. Decreasing abundances of temperate/subpolar species in the late 20th century indicate a deep, penetrative warming not observed in previous centuries. These results imply that 20th-century warming, apparently anthropogenic, has already affected lower trophic levels of the California Current.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Field, David B -- Baumgartner, Timothy R -- Charles, Christopher D -- Ferreira-Bartrina, Vicente -- Ohman, Mark D -- New York, N.Y. -- Science. 2006 Jan 6;311(5757):63-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093, USA. dfield@mbari.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16400144" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; California ; *Climate ; *Ecosystem ; Environment ; *Eukaryota/classification ; *Geologic Sediments ; Greenhouse Effect ; Population Density ; Population Dynamics ; Principal Component Analysis ; Seasons ; Temperature ; Time Factors ; *Zooplankton/classification
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 5
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2007-02-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walther, Gian-Reto -- New York, N.Y. -- Science. 2007 Feb 2;315(5812):606-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Plant Ecology, University of Bayreuth, 95440 Bayreuth, Germany. gian-reto.walther@uni-bayreuth.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17272708" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biodiversity ; California ; *Climate ; *Ecosystem ; *Invertebrates/physiology ; *Plant Development ; Poaceae/growth & development ; Population Dynamics ; Rain ; Research Design ; Seasons ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 6
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2007-06-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Parson, William W -- New York, N.Y. -- Science. 2007 Jun 8;316(5830):1438-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, University of Washington, Seattle, WA 98195, USA. parsonb@u.washington.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17556574" target="_blank"〉PubMed〈/a〉
    Keywords: Bacteriochlorophylls/chemistry/*metabolism ; Chemistry, Physical ; Energy Transfer ; Pheophytins/chemistry/*metabolism ; Photons ; *Photosynthesis ; Photosynthetic Reaction Center Complex Proteins/chemistry/*metabolism ; Physicochemical Phenomena ; Rhodobacter sphaeroides/chemistry/*metabolism ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 7
    Publication Date: 2007-01-20
    Description: Litter decomposition provides the primary source of mineral nitrogen (N) for biological activity in most terrestrial ecosystems. A 10-year decomposition experiment in 21 sites from seven biomes found that net N release from leaf litter is dominantly driven by the initial tissue N concentration and mass remaining regardless of climate, edaphic conditions, or biota. Arid grasslands exposed to high ultraviolet radiation were an exception, where net N release was insensitive to initial N. Roots released N linearly with decomposition and exhibited little net N immobilization. We suggest that fundamental constraints on decomposer physiologies lead to predictable global-scale patterns in net N release during decomposition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Parton, William -- Silver, Whendee L -- Burke, Ingrid C -- Grassens, Leo -- Harmon, Mark E -- Currie, William S -- King, Jennifer Y -- Adair, E Carol -- Brandt, Leslie A -- Hart, Stephen C -- Fasth, Becky -- New York, N.Y. -- Science. 2007 Jan 19;315(5810):361-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Natural Resource Ecology Laboratory, Colorado State University, 200 West Lake, Campus Mail 1499, Fort Collins, CO 80523-1499, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17234944" target="_blank"〉PubMed〈/a〉
    Keywords: *Biodegradation, Environmental ; Carbon/metabolism ; Climate ; *Ecosystem ; Humidity ; Mathematics ; Nitrogen/*metabolism ; Plant Leaves/metabolism ; Plant Roots/metabolism ; Plants/*metabolism ; Poaceae ; Regression Analysis ; Seasons ; Soil Microbiology ; Temperature ; Time Factors ; Trees
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 8
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2007-05-26
    Description: Myosin V is a molecular motor that moves cargo along actin filaments. Its two heads, each attached to a long and relatively stiff neck, move alternately forward in a "hand-over-hand" fashion. To observe under a microscope how the necks move, we attached a micrometer-sized rod to one of the necks. The leading neck swings unidirectionally forward, whereas the trailing neck, once lifted, undergoes extensive Brownian rotation in all directions before landing on a site ahead of the leading head. The neck-neck joint is essentially free, and the neck motion supports a mechanism where the active swing of the leading neck biases the random motion of the lifted head to let it eventually land on a forward site.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shiroguchi, Katsuyuki -- Kinosita, Kazuhiko Jr -- New York, N.Y. -- Science. 2007 May 25;316(5828):1208-12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, Faculty of Science and Engineering, Waseda University, Okubo 3-4-1, Shinjuku-ku, Tokyo 169-8555, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17525343" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/physiology ; Animals ; Chickens ; Microscopy, Fluorescence ; Motion ; Myosin Type V/*physiology ; Rabbits
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 9
    Publication Date: 2007-04-07
    Description: Information on responses of higher organisms to climate change is dominated by events in spring. Far less is known about autumnal events and virtually nothing about communities of microorganisms. We analyzed autumnal fruiting patterns of macrofungi over the past 56 years and found that average first fruiting date of 315 species is earlier, while last fruiting date is later. Fruiting of mycorrhizal species that associate with both deciduous and coniferous trees is delayed in deciduous, but not in coniferous, forests. Many species are now fruiting twice a year, indicating increased mycelial activity and possibly greater decay rates in ecosystems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gange, A C -- Gange, E G -- Sparks, T H -- Boddy, L -- New York, N.Y. -- Science. 2007 Apr 6;316(5821):71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Biological Sciences, Royal Holloway, University of London, Egham, Surrey TW20 0EX, UK. a.gange@rhul.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17412949" target="_blank"〉PubMed〈/a〉
    Keywords: Coniferophyta/microbiology ; *Ecosystem ; England ; Fruiting Bodies, Fungal/*growth & development ; Fungi/*growth & development ; Mycorrhizae/*growth & development ; Seasons ; Temperature ; Time Factors ; Trees/microbiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 10
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2007-04-07
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2271071/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2271071/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Squire, Larry R -- R01 MH024600/MH/NIMH NIH HHS/ -- R01 MH024600-33/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2007 Apr 6;316(5821):57-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉VA Medical Center, San Diego, CA 92161, USA. lsquire@ucsd.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17412942" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Association Learning ; Cues ; Hippocampus/*physiology ; *Memory ; Mental Recall ; Neocortex/*physiology ; Rats ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 11
    Publication Date: 2007-11-17
    Description: Artificial biochemical circuits are likely to play as large a role in biological engineering as electrical circuits have played in the engineering of electromechanical devices. Toward that end, nucleic acids provide a designable substrate for the regulation of biochemical reactions. However, it has been difficult to incorporate signal amplification components. We introduce a design strategy that allows a specified input oligonucleotide to catalyze the release of a specified output oligonucleotide, which in turn can serve as a catalyst for other reactions. This reaction, which is driven forward by the configurational entropy of the released molecule, provides an amplifying circuit element that is simple, fast, modular, composable, and robust. We have constructed and characterized several circuits that amplify nucleic acid signals, including a feedforward cascade with quadratic kinetics and a positive feedback circuit with exponential growth kinetics.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhang, David Yu -- Turberfield, Andrew J -- Yurke, Bernard -- Winfree, Erik -- New York, N.Y. -- Science. 2007 Nov 16;318(5853):1121-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Computation and Neural Systems, California Institute of Technology, MC 136-93, 1200 East California Boulevard, Pasadena, CA91125, USA. dzhang@dna.caltech.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18006742" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Catalysis ; Chemical Engineering ; *Computers, Molecular ; DNA/*chemistry ; Entropy ; Equipment Design ; Feedback, Physiological ; Mice ; Nanotechnology ; Nucleic Acid Hybridization ; Rabbits
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 12
    Publication Date: 2007-03-24
    Description: Grid cells in layer II of rat entorhinal cortex fire to spatial locations in a repeating hexagonal grid, with smaller spacing between grid fields for neurons in more dorsal anatomical locations. Data from in vitro whole-cell patch recordings showed differences in frequency of subthreshold membrane potential oscillations in entorhinal neurons that correspond to different positions along the dorsal-to-ventral axis, supporting a model of physiological mechanisms for grid cell responses.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950607/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950607/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Giocomo, Lisa M -- Zilli, Eric A -- Fransen, Erik -- Hasselmo, Michael E -- DA16454/DA/NIDA NIH HHS/ -- MH60013/MH/NIMH NIH HHS/ -- MH71702/MH/NIMH NIH HHS/ -- P50 MH071702/MH/NIMH NIH HHS/ -- P50 MH071702-01A20004/MH/NIMH NIH HHS/ -- R01 DA016454/DA/NIDA NIH HHS/ -- R01 DA016454-04/DA/NIDA NIH HHS/ -- R01 DA016454-05/DA/NIDA NIH HHS/ -- R01 MH060013/MH/NIMH NIH HHS/ -- R01 MH060013-05/MH/NIMH NIH HHS/ -- R01 MH060013-06/MH/NIMH NIH HHS/ -- R01 MH061492/MH/NIMH NIH HHS/ -- R01 MH061492-05/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2007 Mar 23;315(5819):1719-22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Memory and Brain, Department of Psychology, Program in Neuroscience, Boston University, 2 Cummington Street, Boston, MA 02215, USA. giocomo@bu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17379810" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Animals ; Computer Simulation ; Dendrites/physiology ; Electric Stimulation ; Entorhinal Cortex/*cytology/*physiology ; Female ; In Vitro Techniques ; Male ; Mathematics ; Membrane Potentials ; Models, Neurological ; Movement ; Neurons/cytology/*physiology ; Patch-Clamp Techniques ; Periodicity ; Rats ; Rats, Long-Evans ; Space Perception ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 13
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2007-08-25
    Description: Because bacterial recombination involves the occasional transfer of small DNA fragments between strains, different sets of niche-specific genes may be maintained in populations that freely recombine at other loci. Therefore, genetic isolation may be established at different times for different chromosomal regions during speciation as recombination at niche-specific genes is curtailed. To test this model, we separated sequence divergence into rate and time components, revealing that different regions of the Escherichia coli and Salmonella enterica chromosomes diverged over a approximately 70-million-year period. Genetic isolation first occurred at regions carrying species-specific genes, indicating that physiological distinctiveness between the nascent Escherichia and Salmonella lineages was maintained for tens of millions of years before the complete genetic isolation of their chromosomes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Retchless, Adam C -- Lawrence, Jeffrey G -- GM078092/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2007 Aug 24;317(5841):1093-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17717188" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Buchnera/*genetics ; Chromosomes, Bacterial ; Escherichia coli/*genetics ; Genes, Bacterial ; *Genetic Speciation ; Genome, Bacterial ; Models, Genetic ; *Recombination, Genetic ; Salmonella enterica/*genetics ; Species Specificity ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 14
    Publication Date: 2007-11-17
    Description: Transection of the direct cortico-motoneuronal pathway at the mid-cervical segment of the spinal cord in the macaque monkey results in a transient impairment of finger movements. Finger dexterity recovers within a few months. Combined brain imaging and reversible pharmacological inactivation of motor cortical regions suggest that the recovery involves the bilateral primary motor cortex during the early recovery stage and more extensive regions of the contralesional primary motor cortex and bilateral premotor cortex during the late recovery stage. These changes in the activation pattern of frontal motor-related areas represent an adaptive strategy for functional compensation after spinal cord injury.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nishimura, Yukio -- Onoe, Hirotaka -- Morichika, Yosuke -- Perfiliev, Sergei -- Tsukada, Hideo -- Isa, Tadashi -- New York, N.Y. -- Science. 2007 Nov 16;318(5853):1150-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki 444-8585, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18006750" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Animals ; Brain Mapping ; Female ; Fingers/*physiopathology ; GABA Agonists ; Learning ; Macaca ; Macaca mulatta ; Male ; *Motor Skills ; Muscimol ; Nerve Net/physiopathology ; Positron-Emission Tomography ; *Recovery of Function ; Spinal Cord Injuries/*physiopathology/rehabilitation ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 15
    Publication Date: 2007-04-07
    Description: Memory encoding occurs rapidly, but the consolidation of memory in the neocortex has long been held to be a more gradual process. We now report, however, that systems consolidation can occur extremely quickly if an associative "schema" into which new information is incorporated has previously been created. In experiments using a hippocampal-dependent paired-associate task for rats, the memory of flavor-place associations became persistent over time as a putative neocortical schema gradually developed. New traces, trained for only one trial, then became assimilated and rapidly hippocampal-independent. Schemas also played a causal role in the creation of lasting associative memory representations during one-trial learning. The concept of neocortical schemas may unite psychological accounts of knowledge structures with neurobiological theories of systems memory consolidation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tse, Dorothy -- Langston, Rosamund F -- Kakeyama, Masaki -- Bethus, Ingrid -- Spooner, Patrick A -- Wood, Emma R -- Witter, Menno P -- Morris, Richard G M -- G9200370/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2007 Apr 6;316(5821):76-82.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory for Cognitive Neuroscience, Centre for Cognitive and Neural Systems, and Centre for Neuroscience Research, University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, Scotland, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17412951" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Association Learning ; Cues ; Hippocampus/*physiology ; Male ; *Memory ; Mental Recall ; Neocortex/*physiology ; Rats ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 16
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2007-10-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cheke, Robert A -- New York, N.Y. -- Science. 2007 Oct 26;318(5850):577-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Natural Resources Institute, University of Greenwich at Medway, Chatham Maritime, Kent ME4 4TB, UK. r.a.cheke@greenwich.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17962543" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; China ; *Climate ; Disasters ; *Ecology ; Europe ; *Grasshoppers/physiology ; Greenhouse Effect ; *Larix ; *Moths/physiology ; Population Density ; Population Dynamics ; Rain ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 17
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-02-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2008 Feb 15;319(5865):884-5. doi: 10.1126/science.319.5865.884.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18276854" target="_blank"〉PubMed〈/a〉
    Keywords: Blood Glucose/*analysis ; Cardiovascular Diseases/epidemiology/prevention & control ; Controlled Clinical Trials as Topic ; Diabetes Mellitus, Type 2/blood/complications/*drug therapy/mortality ; Hemoglobin A, Glycosylated/analysis ; Humans ; Hypoglycemic Agents/*therapeutic use ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 18
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-08-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lyon, Bruce E -- Chaine, Alexis S -- Winkler, David W -- New York, N.Y. -- Science. 2008 Aug 22;321(5892):1051-2. doi: 10.1126/science.1159822.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolutionary Biology, University of California, Santa Cruz, CA 95064, USA. lyon@biology.ucsc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18719273" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; *Climate ; Cues ; Environment ; Female ; Male ; *Oviposition ; Passeriformes/genetics/*physiology ; Phenotype ; Photoperiod ; Seasons ; Selection, Genetic ; Temperature ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 19
    Publication Date: 2008-07-05
    Description: It has previously been thought that there was a steep Cretaceous and Cenozoic radiation of marine invertebrates. This pattern can be replicated with a new data set of fossil occurrences representing 3.5 million specimens, but only when older analytical protocols are used. Moreover, analyses that employ sampling standardization and more robust counting methods show a modest rise in diversity with no clear trend after the mid-Cretaceous. Globally, locally, and at both high and low latitudes, diversity was less than twice as high in the Neogene as in the mid-Paleozoic. The ratio of global to local richness has changed little, and a latitudinal diversity gradient was present in the early Paleozoic.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alroy, John -- Aberhan, Martin -- Bottjer, David J -- Foote, Michael -- Fursich, Franz T -- Harries, Peter J -- Hendy, Austin J W -- Holland, Steven M -- Ivany, Linda C -- Kiessling, Wolfgang -- Kosnik, Matthew A -- Marshall, Charles R -- McGowan, Alistair J -- Miller, Arnold I -- Olszewski, Thomas D -- Patzkowsky, Mark E -- Peters, Shanan E -- Villier, Loic -- Wagner, Peter J -- Bonuso, Nicole -- Borkow, Philip S -- Brenneis, Benjamin -- Clapham, Matthew E -- Fall, Leigh M -- Ferguson, Chad A -- Hanson, Victoria L -- Krug, Andrew Z -- Layou, Karen M -- Leckey, Erin H -- Nurnberg, Sabine -- Powers, Catherine M -- Sessa, Jocelyn A -- Simpson, Carl -- Tomasovych, Adam -- Visaggi, Christy C -- New York, N.Y. -- Science. 2008 Jul 4;321(5885):97-100. doi: 10.1126/science.1156963.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Center for Ecological Analysis and Synthesis, University of California-Santa Barbara, 735 State Street, Santa Barbara, CA 93101, USA. alroy@nceas.ucsb.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18599780" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biodiversity ; Biological Evolution ; Databases, Factual ; Environment ; *Fossils ; Geography ; Geologic Sediments ; *Invertebrates/classification ; *Paleontology/methods ; Population Dynamics ; Sampling Studies ; Seawater ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 20
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-02-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sherwood, Steven C -- New York, N.Y. -- Science. 2008 Feb 15;319(5865):900. doi: 10.1126/science.319.5865.900b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18276868" target="_blank"〉PubMed〈/a〉
    Keywords: *Climate ; *Policy Making ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 21
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-07-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2008 Jul 4;321(5885):24-5. doi: 10.1126/science.321.5885.24b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18599747" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Evolution ; *Climate ; *Ecosystem ; Flowers/*growth & development ; Greenhouse Effect ; Massachusetts ; *Plant Development ; Seasons ; Species Specificity ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 22
    Publication Date: 2008-02-09
    Description: Increasing energy use, climate change, and carbon dioxide (CO2) emissions from fossil fuels make switching to low-carbon fuels a high priority. Biofuels are a potential low-carbon energy source, but whether biofuels offer carbon savings depends on how they are produced. Converting rainforests, peatlands, savannas, or grasslands to produce food crop-based biofuels in Brazil, Southeast Asia, and the United States creates a "biofuel carbon debt" by releasing 17 to 420 times more CO2 than the annual greenhouse gas (GHG) reductions that these biofuels would provide by displacing fossil fuels. In contrast, biofuels made from waste biomass or from biomass grown on degraded and abandoned agricultural lands planted with perennials incur little or no carbon debt and can offer immediate and sustained GHG advantages.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fargione, Joseph -- Hill, Jason -- Tilman, David -- Polasky, Stephen -- Hawthorne, Peter -- New York, N.Y. -- Science. 2008 Feb 29;319(5867):1235-8. doi: 10.1126/science.1152747. Epub 2008 Feb 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Nature Conservancy, 1101 West River Parkway, Suite 200, Minneapolis, MN 55415, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18258862" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomass ; Brazil ; Carbon ; *Carbon Dioxide/metabolism ; Crops, Agricultural ; *Ecosystem ; *Energy-Generating Resources ; Greenhouse Effect ; Indonesia ; Malaysia ; Plant Development ; *Plants/metabolism ; *Soil ; Time Factors ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 23
    Publication Date: 2008-04-12
    Description: Initiation of actin polymerization in cells requires nucleation factors. Here we describe an actin-binding protein, leiomodin, that acted as a strong filament nucleator in muscle cells. Leiomodin shared two actin-binding sites with the filament pointed end-capping protein tropomodulin: a flexible N-terminal region and a leucine-rich repeat domain. Leiomodin also contained a C-terminal extension of 150 residues. The smallest fragment with strong nucleation activity included the leucine-rich repeat and C-terminal extension. The N-terminal region enhanced the nucleation activity threefold and recruited tropomyosin, which weakly stimulated nucleation and mediated localization of leiomodin to the middle of muscle sarcomeres. Knocking down leiomodin severely compromised sarcomere assembly in cultured muscle cells, which suggests a role for leiomodin in the nucleation of tropomyosin-decorated filaments in muscles.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845909/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845909/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chereau, David -- Boczkowska, Malgorzata -- Skwarek-Maruszewska, Aneta -- Fujiwara, Ikuko -- Hayes, David B -- Rebowski, Grzegorz -- Lappalainen, Pekka -- Pollard, Thomas D -- Dominguez, Roberto -- GM026338/GM/NIGMS NIH HHS/ -- GM073791/GM/NIGMS NIH HHS/ -- HL086655/HL/NHLBI NIH HHS/ -- P01 HL086655/HL/NHLBI NIH HHS/ -- P01 HL086655-01A10004/HL/NHLBI NIH HHS/ -- R01 GM073791/GM/NIGMS NIH HHS/ -- R01 GM073791-04/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2008 Apr 11;320(5873):239-43. doi: 10.1126/science.1155313.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Boston Biomedical Research Institute, Watertown, MA 02472, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18403713" target="_blank"〉PubMed〈/a〉
    Keywords: Actin Cytoskeleton/*metabolism ; Actins/metabolism ; Amino Acid Sequence ; Animals ; Binding Sites ; Cells, Cultured ; Cytoskeletal Proteins/chemistry/*metabolism ; Humans ; Microfilament Proteins/chemistry/*metabolism ; Molecular Sequence Data ; Muscle Proteins/chemistry/*metabolism ; Myocytes, Cardiac/*metabolism ; Protein Structure, Tertiary ; RNA Interference ; Rabbits ; Rats ; Sarcomeres/*metabolism ; Tropomodulin/chemistry ; Tropomyosin/chemistry/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 24
    Publication Date: 2008-07-05
    Description: The ability to sense molecular tension is crucial for a wide array of cellular processes, including the detection of auditory stimuli, control of cell shape, and internalization and transport of membranes. We show that myosin I, a motor protein that has been implicated in powering key steps in these processes, dramatically alters its motile properties in response to tension. We measured the displacement generated by single myosin I molecules, and we determined the actin-attachment kinetics with varying tensions using an optical trap. The rate of myosin I detachment from actin decreases 〉75-fold under tension of 2 piconewtons or less, resulting in myosin I transitioning from a low (〈0.2) to a high (〉0.9) duty-ratio motor. This impressive tension sensitivity supports a role for myosin I as a molecular force sensor.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493443/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493443/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Laakso, Joseph M -- Lewis, John H -- Shuman, Henry -- Ostap, E Michael -- AR051174/AR/NIAMS NIH HHS/ -- GM057247/GM/NIGMS NIH HHS/ -- P01 AR051174/AR/NIAMS NIH HHS/ -- P01 AR051174-050003/AR/NIAMS NIH HHS/ -- R01 GM057247-10/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2008 Jul 4;321(5885):133-6. doi: 10.1126/science.1159419.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Pennsylvania Muscle Institute and Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18599791" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/*metabolism ; Actomyosin/physiology ; Adenosine Diphosphate/metabolism ; Adenosine Triphosphate/metabolism ; Amino Acid Motifs ; Animals ; Biophysical Phenomena ; Biophysics ; Kinetics ; Likelihood Functions ; Models, Biological ; Molecular Motor Proteins/metabolism/*physiology ; Monte Carlo Method ; Myosin Type I/chemistry/metabolism/*physiology ; Optical Tweezers ; Protein Structure, Tertiary ; Rabbits ; Stress, Mechanical
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 25
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-04-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, Greg -- New York, N.Y. -- Science. 2008 Apr 11;320(5873):167. doi: 10.1126/science.320.5873.167a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18403684" target="_blank"〉PubMed〈/a〉
    Keywords: Brain/*pathology ; Brain Chemistry ; *Brain Tissue Transplantation ; *Fetal Tissue Transplantation ; Graft Survival ; Humans ; Neurons/chemistry/*pathology/transplantation ; Parkinson Disease/metabolism/*pathology/*surgery ; Time Factors ; Ubiquitin/analysis ; alpha-Synuclein/analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 26
    Publication Date: 2008-01-26
    Description: The residence time of fine-root carbon in soil is one of the least understood aspects of the global carbon cycle, and fine-root dynamics are one of the least understood aspects of plant function. Most recent studies of these belowground dynamics have used one of two methodological strategies. In one approach, based on analysis of carbon isotopes, the persistence of carbon is inferred; in the other, based on direct observations of roots with cameras, the longevity of individual roots is measured. We show that the contribution of fine roots to the global carbon cycle has been overstated because observations of root lifetimes systematically overestimate the turnover of fine-root biomass. On the other hand, isotopic techniques systematically underestimate the turnover of individual roots. These differences, by virtue of the separate processes or pools measured, are irreconcilable.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Strand, Allan E -- Pritchard, Seth G -- McCormack, M Luke -- Davis, Micheal A -- Oren, Ram -- New York, N.Y. -- Science. 2008 Jan 25;319(5862):456-8. doi: 10.1126/science.1151382.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, College of Charleston, Charleston, SC 29424, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18218895" target="_blank"〉PubMed〈/a〉
    Keywords: Atmosphere ; Biomass ; Botany/methods ; Carbon/*analysis ; Carbon Dioxide/analysis/metabolism ; Carbon Isotopes ; Chemistry Techniques, Analytical/methods ; Miniaturization ; Plant Roots/chemistry/*physiology ; Soil/*analysis ; Time Factors ; Video Recording
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 27
    Publication Date: 2008-04-05
    Description: Recent experiments with rats suggest that they show episodic-like or what-where-when memory for a preferred food found on a radial maze. Although memory for when a salient event occurred suggests that rats can mentally travel in time to a moment in the past, an alternative possibility is that they remember how long ago the food was found. Three groups of rats were tested for memory of previously encountered food. The different groups could use only the cues of when, how long ago, or when + how long ago. Only the cue of how long ago food was encountered was used successfully. These results suggest that episodic-like memory in rats is qualitatively different from human episodic memory.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roberts, William A -- Feeney, Miranda C -- Macpherson, Krista -- Petter, Mark -- McMillan, Neil -- Musolino, Evanya -- New York, N.Y. -- Science. 2008 Apr 4;320(5872):113-5. doi: 10.1126/science.1152709.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, University of Western Ontario, London, Ontario, N6A 5C2, Canada. roberts@uwo.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18388296" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cues ; Male ; Maze Learning ; *Memory ; Random Allocation ; Rats ; Rats, Long-Evans ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 28
    Publication Date: 2008-10-11
    Description: We provide a century-scale view of small-mammal responses to global warming, without confounding effects of land-use change, by repeating Grinnell's early-20th century survey across a 3000-meter-elevation gradient that spans Yosemite National Park, California, USA. Using occupancy modeling to control for variation in detectability, we show substantial ( approximately 500 meters on average) upward changes in elevational limits for half of 28 species monitored, consistent with the observed approximately 3 degrees C increase in minimum temperatures. Formerly low-elevation species expanded their ranges and high-elevation species contracted theirs, leading to changed community composition at mid- and high elevations. Elevational replacement among congeners changed because species' responses were idiosyncratic. Though some high-elevation species are threatened, protection of elevation gradients allows other species to respond via migration.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moritz, Craig -- Patton, James L -- Conroy, Chris J -- Parra, Juan L -- White, Gary C -- Beissinger, Steven R -- New York, N.Y. -- Science. 2008 Oct 10;322(5899):261-4. doi: 10.1126/science.1163428.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Museum of Vertebrate Zoology, University of California, Berkeley, CA 94720, USA. craigm@berkeley.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18845755" target="_blank"〉PubMed〈/a〉
    Keywords: Acclimatization ; Altitude ; Animal Migration ; Animals ; *Biodiversity ; California ; *Climate ; *Ecosystem ; *Greenhouse Effect ; *Mammals ; Population Dynamics ; Temperature ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 29
    Publication Date: 2009-04-04
    Description: We modeled the mobility of mobile phone users in order to study the fundamental spreading patterns that characterize a mobile virus outbreak. We find that although Bluetooth viruses can reach all susceptible handsets with time, they spread slowly because of human mobility, offering ample opportunities to deploy antiviral software. In contrast, viruses using multimedia messaging services could infect all users in hours, but currently a phase transition on the underlying call graph limits them to only a small fraction of the susceptible users. These results explain the lack of a major mobile virus breakout so far and predict that once a mobile operating system's market share reaches the phase transition point, viruses will pose a serious threat to mobile communications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, Pu -- Gonzalez, Marta C -- Hidalgo, Cesar A -- Barabasi, Albert-Laszlo -- New York, N.Y. -- Science. 2009 May 22;324(5930):1071-6. doi: 10.1126/science.1167053. Epub 2009 Apr 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Complex Network Research, Departments of Physics, Biology, and Computer Science, Northeastern University, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19342553" target="_blank"〉PubMed〈/a〉
    Keywords: *Cell Phones ; *Computer Security ; Humans ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 30
    Publication Date: 2009-07-04
    Description: The light detection and ranging instrument on the Phoenix mission observed water-ice clouds in the atmosphere of Mars that were similar to cirrus clouds on Earth. Fall streaks in the cloud structure traced the precipitation of ice crystals toward the ground. Measurements of atmospheric dust indicated that the planetary boundary layer (PBL) on Mars was well mixed, up to heights of around 4 kilometers, by the summer daytime turbulence and convection. The water-ice clouds were detected at the top of the PBL and near the ground each night in late summer after the air temperature started decreasing. The interpretation is that water vapor mixed upward by daytime turbulence and convection forms ice crystal clouds at night that precipitate back toward the surface.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Whiteway, J A -- Komguem, L -- Dickinson, C -- Cook, C -- Illnicki, M -- Seabrook, J -- Popovici, V -- Duck, T J -- Davy, R -- Taylor, P A -- Pathak, J -- Fisher, D -- Carswell, A I -- Daly, M -- Hipkin, V -- Zent, A P -- Hecht, M H -- Wood, S E -- Tamppari, L K -- Renno, N -- Moores, J E -- Lemmon, M T -- Daerden, F -- Smith, P H -- New York, N.Y. -- Science. 2009 Jul 3;325(5936):68-70. doi: 10.1126/science.1172344.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Earth and Space Science and Engineering, York University, Toronto, Ontario, Canada. whiteway@yorku.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19574386" target="_blank"〉PubMed〈/a〉
    Keywords: Atmosphere ; Extraterrestrial Environment ; *Ice ; *Mars ; Spacecraft ; *Steam ; Temperature ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 31
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-08-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, Greg -- New York, N.Y. -- Science. 2009 Aug 7;325(5941):670-2. doi: 10.1126/science.325_670.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19661398" target="_blank"〉PubMed〈/a〉
    Keywords: Athletic Injuries/etiology/metabolism/*pathology ; Brain/*pathology ; Brain Chemistry ; Brain Concussion ; Brain Injury, Chronic/etiology/metabolism/*pathology ; Football/*injuries ; Humans ; Male ; Post-Concussion Syndrome/etiology/metabolism/pathology ; Risk Factors ; Tauopathies/etiology/metabolism/pathology ; Time Factors ; tau Proteins/analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 32
    Publication Date: 2009-03-28
    Description: In the early stages of viral infection, outcomes depend on a race between expansion of infection and the immune response generated to contain it. We combined in situ tetramer staining with in situ hybridization to visualize, map, and quantify relationships between immune effector cells and their targets in tissues. In simian immunodeficiency virus infections in macaques and lymphocytic choriomeningitis virus infections in mice, the magnitude and timing of the establishment of an excess of effector cells versus targets were found to correlate with the extent of control and the infection outcome (i.e., control and clearance versus partial or poor control and persistent infection). This method highlights the importance of the location, timing, and magnitude of the immune response needed for a vaccine to be effective against agents of persistent infection, such as HIV-1.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753492/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753492/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, Qingsheng -- Skinner, Pamela J -- Ha, Sang-Jun -- Duan, Lijie -- Mattila, Teresa L -- Hage, Aaron -- White, Cara -- Barber, Daniel L -- O'Mara, Leigh -- Southern, Peter J -- Reilly, Cavan S -- Carlis, John V -- Miller, Christopher J -- Ahmed, Rafi -- Haase, Ashley T -- AI066314/AI/NIAID NIH HHS/ -- AI20048/AI/NIAID NIH HHS/ -- AI48484/AI/NIAID NIH HHS/ -- P01 AI066314/AI/NIAID NIH HHS/ -- P01 AI066314-010003/AI/NIAID NIH HHS/ -- P01 AI066314-020003/AI/NIAID NIH HHS/ -- P01 AI066314-030003/AI/NIAID NIH HHS/ -- P01 AI066314-040003/AI/NIAID NIH HHS/ -- P51 RR000169/RR/NCRR NIH HHS/ -- P51 RR000169-430198/RR/NCRR NIH HHS/ -- R01 AI048484/AI/NIAID NIH HHS/ -- R01 AI048484-01/AI/NIAID NIH HHS/ -- R01 AI048484-02/AI/NIAID NIH HHS/ -- R01 AI048484-03/AI/NIAID NIH HHS/ -- R01 AI048484-04/AI/NIAID NIH HHS/ -- RR00169/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2009 Mar 27;323(5922):1726-9. doi: 10.1126/science.1168676.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19325114" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arenaviridae Infections/*immunology/virology ; Cell Count ; Cervix Uteri/immunology/virology ; Female ; In Situ Hybridization ; Lymph Nodes/immunology/virology ; Lymphocytic choriomeningitis virus/*immunology ; Lymphoid Tissue/immunology/virology ; Macaca mulatta ; Mice ; RNA, Viral/analysis ; Simian Acquired Immunodeficiency Syndrome/*immunology/virology ; Simian Immunodeficiency Virus/*immunology/physiology ; Spleen/immunology/virology ; Staining and Labeling ; T-Lymphocytes, Cytotoxic/*immunology ; Time Factors ; Vagina/immunology/virology ; Virus Replication
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 33
    Publication Date: 2009-08-22
    Description: The paradigmatic feature of long-term memory (LTM) is its persistence. However, little is known about the mechanisms that make some LTMs last longer than others. In rats, a long-lasting fear LTM vanished rapidly when the D1 dopamine receptor antagonist SCH23390 was injected into the dorsal hippocampus 12 hours, but not immediately or 9 hours, after the fearful experience. Conversely, intrahippocampal application of the D1 agonist SK38393 at the same critical post-training time converted a rapidly decaying fear LTM into a persistent one. This effect was mediated by brain-derived neurotrophic factor and regulated by the ventral tegmental area (VTA). Thus, the persistence of LTM depends on activation of VTA/hippocampus dopaminergic connections and can be specifically modulated by manipulating this system at definite post-learning time points.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rossato, Janine I -- Bevilaqua, Lia R M -- Izquierdo, Ivan -- Medina, Jorge H -- Cammarota, Martin -- New York, N.Y. -- Science. 2009 Aug 21;325(5943):1017-20. doi: 10.1126/science.1172545.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centro de Memoria, Instituto do Cerebro, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19696353" target="_blank"〉PubMed〈/a〉
    Keywords: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine/pharmacology ; 8-Bromo Cyclic Adenosine Monophosphate/pharmacology ; Animals ; Benzazepines/pharmacology ; Brain-Derived Neurotrophic Factor/metabolism ; Dopamine/*physiology ; Dopamine Agonists/pharmacology ; Dopamine Antagonists/pharmacology ; Fear ; Hippocampus/drug effects/*physiology ; Male ; Memory/drug effects/*physiology ; Phosphorylation ; Rats ; Rats, Wistar ; Receptors, Dopamine D1/agonists/antagonists & inhibitors/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism ; Time Factors ; Tyrosine 3-Monooxygenase ; Ventral Tegmental Area/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 34
    Publication Date: 2009-03-28
    Description: Similarities in the behavior of diverse animal species that form large groups have motivated attempts to establish general principles governing animal group behavior. It has been difficult, however, to make quantitative measurements of the temporal and spatial behavior of extensive animal groups in the wild, such as bird flocks, fish shoals, and locust swarms. By quantifying the formation processes of vast oceanic fish shoals during spawning, we show that (i) a rapid transition from disordered to highly synchronized behavior occurs as population density reaches a critical value; (ii) organized group migration occurs after this transition; and (iii) small sets of leaders significantly influence the actions of much larger groups. Each of these findings confirms general theoretical predictions believed to apply in nature irrespective of animal species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Makris, Nicholas C -- Ratilal, Purnima -- Jagannathan, Srinivasan -- Gong, Zheng -- Andrews, Mark -- Bertsatos, Ioannis -- Godo, Olav Rune -- Nero, Redwood W -- Jech, J Michael -- New York, N.Y. -- Science. 2009 Mar 27;323(5922):1734-7. doi: 10.1126/science.1169441.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. makris@mit.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19325116" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Migration ; Animals ; Atlantic Ocean ; *Behavior, Animal ; Ecosystem ; Fishes/*physiology ; Population Density ; Reproduction ; Spatial Behavior ; *Swimming ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 35
    Publication Date: 2009-09-26
    Description: The identification and modeling of patterns of human activity have important ramifications for applications ranging from predicting disease spread to optimizing resource allocation. Because of its relevance and availability, written correspondence provides a powerful proxy for studying human activity. One school of thought is that human correspondence is driven by responses to received correspondence, a view that requires a distinct response mechanism to explain e-mail and letter correspondence observations. We demonstrate that, like e-mail correspondence, the letter correspondence patterns of 16 writers, performers, politicians, and scientists are well described by the circadian cycle, task repetition, and changing communication needs. We confirm the universality of these mechanisms by rescaling letter and e-mail correspondence statistics to reveal their underlying similarity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malmgren, R Dean -- Stouffer, Daniel B -- Campanharo, Andriana S L O -- Amaral, Luis A Nunes -- New York, N.Y. -- Science. 2009 Sep 25;325(5948):1696-700. doi: 10.1126/science.1174562.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208, USA. dean.malmgren@u.northwestern.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19779200" target="_blank"〉PubMed〈/a〉
    Keywords: *Behavior ; Circadian Rhythm ; *Communication ; *Correspondence as Topic ; Electronic Mail ; *Human Activities ; Humans ; Models, Statistical ; Monte Carlo Method ; Normal Distribution ; Occupations ; Poisson Distribution ; Politics ; Probability ; Science ; Time Factors ; Writing
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 36
    Publication Date: 2009-10-17
    Description: Words, grammar, and phonology are linguistically distinct, yet their neural substrates are difficult to distinguish in macroscopic brain regions. We investigated whether they can be separated in time and space at the circuit level using intracranial electrophysiology (ICE), namely by recording local field potentials from populations of neurons using electrodes implanted in language-related brain regions while people read words verbatim or grammatically inflected them (present/past or singular/plural). Neighboring probes within Broca's area revealed distinct neuronal activity for lexical (approximately 200 milliseconds), grammatical (approximately 320 milliseconds), and phonological (approximately 450 milliseconds) processing, identically for nouns and verbs, in a region activated in the same patients and task in functional magnetic resonance imaging. This suggests that a linguistic processing sequence predicted on computational grounds is implemented in the brain in fine-grained spatiotemporally patterned activity.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030760/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030760/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sahin, Ned T -- Pinker, Steven -- Cash, Sydney S -- Schomer, Donald -- Halgren, Eric -- HD18381/HD/NICHD NIH HHS/ -- NS18741/NS/NINDS NIH HHS/ -- NS44623/NS/NINDS NIH HHS/ -- P41 RR014075/RR/NCRR NIH HHS/ -- P41 RR014075-02/RR/NCRR NIH HHS/ -- P41-RR14075/RR/NCRR NIH HHS/ -- R01 HD018381-18/HD/NICHD NIH HHS/ -- R01 NS018741/NS/NINDS NIH HHS/ -- R01 NS018741-22/NS/NINDS NIH HHS/ -- R01 NS044623/NS/NINDS NIH HHS/ -- R01 NS044623-03/NS/NINDS NIH HHS/ -- T32 MH070328-03/MH/NIMH NIH HHS/ -- T32-MH070328/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2009 Oct 16;326(5951):445-9. doi: 10.1126/science.1174481.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Radiology, University of California-San Diego, La Jolla, CA 92037, USA. sahin@post.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19833971" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Brain Mapping ; Electrodes, Implanted ; Electrophysiological Phenomena ; Epilepsy/physiopathology ; Female ; Frontal Lobe/*physiology ; Humans ; *Language ; *Linguistics ; Magnetic Resonance Imaging ; Mental Processes/*physiology ; Middle Aged ; Neurons/*physiology ; Speech/*physiology ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 37
    Publication Date: 2009-12-08
    Description: Phytoplankton--the microalgae that populate the upper lit layers of the ocean--fuel the oceanic food web and affect oceanic and atmospheric carbon dioxide levels through photosynthetic carbon fixation. Here, we show that multidecadal changes in global phytoplankton abundances are related to basin-scale oscillations of the physical ocean, specifically the Pacific Decadal Oscillation and the Atlantic Multidecadal Oscillation. This relationship is revealed in approximately 20 years of satellite observations of chlorophyll and sea surface temperature. Interaction between the main pycnocline and the upper ocean seasonal mixed layer is one mechanism behind this correlation. Our findings provide a context for the interpretation of contemporary changes in global phytoplankton and should improve predictions of their future evolution with climate change.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Martinez, Elodie -- Antoine, David -- D'Ortenzio, Fabrizio -- Gentili, Bernard -- New York, N.Y. -- Science. 2009 Nov 27;326(5957):1253-6. doi: 10.1126/science.1177012.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉UPMC University of Paris 06, UMR 7093, Laboratoire d'Oceanographie de Villefranche (LOV), 06230 Villefranche-sur-Mer, France. martinez@obs-vlfr.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19965473" target="_blank"〉PubMed〈/a〉
    Keywords: Atlantic Ocean ; Biomass ; Chlorophyll/*analysis ; *Climate ; *Ecosystem ; Global Warming ; Indian Ocean ; Oceans and Seas ; Pacific Ocean ; Phytoplankton/*physiology ; Population Dynamics ; Seasons ; *Seawater/chemistry ; Temperature ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 38
    Publication Date: 2005-02-26
    Description: The genomic diversity and relative importance of distinct genotypes within natural bacterial populations have remained largely unknown. Here, we analyze the diversity and annual dynamics of a group of coastal bacterioplankton (greater than 99% 16S ribosomal RNA identity to Vibrio splendidus). We show that this group consists of at least a thousand distinct genotypes, each occurring at extremely low environmental concentrations (on average less than one cell per milliliter). Overall, the genomes show extensive allelic diversity and size variation. Individual genotypes rarely recurred in samples, and allelic distribution did not show spatial or temporal substructure. Ecological considerations suggest that much genotypic and possibly phenotypic variation within natural populations should be considered neutral.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thompson, Janelle R -- Pacocha, Sarah -- Pharino, Chanathip -- Klepac-Ceraj, Vanja -- Hunt, Dana E -- Benoit, Jennifer -- Sarma-Rupavtarm, Ramahi -- Distel, Daniel L -- Polz, Martin F -- New York, N.Y. -- Science. 2005 Feb 25;307(5713):1311-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Civil and Environmental Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15731455" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Chaperonin 60/genetics ; *Ecosystem ; Electrophoresis, Gel, Pulsed-Field ; *Genetic Variation ; Genome, Bacterial ; Genotype ; Molecular Sequence Data ; Plankton/classification/*genetics/growth & development/isolation & purification ; Polymerase Chain Reaction ; Ribotyping ; Seawater/*microbiology ; Time Factors ; Vibrio/classification/*genetics/isolation & purification
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 39
    Publication Date: 2005-09-17
    Description: The activation dynamics of the transcription factor NF-kappaB exhibit damped oscillatory behavior when cells are stimulated by tumor necrosis factor-alpha (TNFalpha) but stable behavior when stimulated by lipopolysaccharide (LPS). LPS binding to Toll-like receptor 4 (TLR4) causes activation of NF-kappaB that requires two downstream pathways, each of which when isolated exhibits damped oscillatory behavior. Computational modeling of the two TLR4-dependent signaling pathways suggests that one pathway requires a time delay to establish early anti-phase activation of NF-kappaB by the two pathways. The MyD88-independent pathway required Inferon regulatory factor 3-dependent expression of TNFalpha to activate NF-kappaB, and the time required for TNFalpha synthesis established the delay.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Covert, Markus W -- Leung, Thomas H -- Gaston, Jahlionais E -- Baltimore, David -- GM039458-21/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2005 Sep 16;309(5742):1854-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16166516" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Proteins, Signal Transducing ; Adaptor Proteins, Vesicular Transport/deficiency/physiology ; Animals ; Antigens, Differentiation/physiology ; Cell Line ; Cells, Cultured ; Computer Simulation ; Cycloheximide/pharmacology ; DNA-Binding Proteins/genetics/physiology ; Gene Expression Profiling ; Gene Expression Regulation ; I-kappa B Kinase ; I-kappa B Proteins/biosynthesis/genetics/metabolism ; Interferon Regulatory Factor-3 ; Kinetics ; Lipopolysaccharides/*immunology/metabolism ; Mice ; Models, Biological ; Myeloid Differentiation Factor 88 ; NF-kappa B/*metabolism ; Oligonucleotide Array Sequence Analysis ; Protein Synthesis Inhibitors/pharmacology ; Protein-Serine-Threonine Kinases/metabolism ; Receptors, Immunologic/deficiency/metabolism/physiology ; Signal Transduction ; Time Factors ; Toll-Like Receptor 4 ; Transcription Factors/genetics/physiology ; Tumor Necrosis Factor-alpha/biosynthesis/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 40
    Publication Date: 2005-10-01
    Description: The oceans are becoming more acidic due to absorption of anthropogenic carbon dioxide from the atmosphere. The impact of ocean acidification on marine ecosystems is unclear, but it will likely depend on species adaptability and the rate of change of seawater pH relative to its natural variability. To constrain the natural variability in reef-water pH, we measured boron isotopic compositions in a approximately 300-year-old massive Porites coral from the southwestern Pacific. Large variations in pH are found over approximately 50-year cycles that covary with the Interdecadal Pacific Oscillation of ocean-atmosphere anomalies, suggesting that natural pH cycles can modulate the impact of ocean acidification on coral reef ecosystems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pelejero, Carles -- Calvo, Eva -- McCulloch, Malcolm T -- Marshall, John F -- Gagan, Michael K -- Lough, Janice M -- Opdyke, Bradley N -- New York, N.Y. -- Science. 2005 Sep 30;309(5744):2204-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Research School of Earth Sciences, Australian National University, Canberra, ACT 0200, Australia. pelejero@cmima.csic.es〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16195458" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anthozoa/chemistry/*physiology ; Atmosphere ; Boron/analysis ; Carbon Dioxide/analysis ; *Ecosystem ; Hydrogen-Ion Concentration ; Isotopes/analysis ; Pacific Ocean ; Seasons ; *Seawater ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 41
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Service, Robert F -- New York, N.Y. -- Science. 2005 Jul 29;309(5735):683.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16051759" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bioreactors ; *Bone Development ; Bone Regeneration ; Bone Transplantation ; Osseointegration ; Periosteum ; Rabbits ; Tibia ; *Tissue Engineering
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 42
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-09-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gray, Russell -- New York, N.Y. -- Science. 2005 Sep 23;309(5743):2007-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, University of Auckland, Auckland 92019, New Zealand. rd.gray@auckland.ac.nz〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16179464" target="_blank"〉PubMed〈/a〉
    Keywords: Asia ; *Cultural Evolution ; Databases, Factual ; History, Ancient ; Humans ; *Language ; *Linguistics ; Pacific Islands ; Papua New Guinea ; Software ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 43
    Publication Date: 2005-07-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Ruiter, Peter C -- Wolters, Volkmar -- Moore, John C -- Winemiller, Kirk O -- New York, N.Y. -- Science. 2005 Jul 1;309(5731):68-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Environmental Sciences, Copernicus Research Institute for Sustainable Development and Innovation, Utrecht University, 3508 TC Utrecht, Netherlands. p.deruiter@geo.uu.nl〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15994518" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biodiversity ; Body Size ; *Ecosystem ; Fishes ; *Food Chain ; Population Density ; Population Dynamics ; Predatory Behavior ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 44
    Publication Date: 2005-05-28
    Description: The typical scales for plant and fungal movements vary over many orders of magnitude in time and length, but they are ultimately based on hydraulics and mechanics. We show that quantification of the length and time scales involved in plant and fungal motions leads to a natural classification, whose physical basis can be understood through an analysis of the mechanics of water transport through an elastic tissue. Our study also suggests a design principle for nonmuscular hydraulically actuated structures: Rapid actuation requires either small size or the enhancement of motion on large scales via elastic instabilities.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Skotheim, Jan M -- Mahadevan, L -- New York, N.Y. -- Science. 2005 May 27;308(5726):1308-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Cambridge CB3 0WA, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15919993" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Wall/physiology ; Droseraceae/anatomy & histology/physiology ; Elasticity ; Euphorbiaceae/anatomy & histology/physiology ; Fungi/cytology/*physiology ; Mathematics ; Movement ; Mucorales/cytology/physiology ; Physical Phenomena ; Physics ; Plant Leaves/*physiology ; *Plant Physiological Phenomena ; Plants/anatomy & histology ; Pressure ; Time Factors ; Viscosity ; Water/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 45
    Publication Date: 2005-08-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anfinrud, Philip -- Schotte, Friedrich -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2005 Aug 19;309(5738):1192-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Chemical Physics, National Institutes of Health, Bethesda, MD 20892-0520, USA. anfinrud@nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16109869" target="_blank"〉PubMed〈/a〉
    Keywords: Hydrocarbons, Iodinated/*chemistry ; Molecular Structure ; Scattering, Radiation ; Solutions ; Solvents ; Time Factors ; X-Ray Diffraction/*methods ; X-Rays
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 46
    Publication Date: 2005-08-16
    Description: Flowering of Arabidopsis is regulated by several environmental and endogenous signals. An important integrator of these inputs is the FLOWERING LOCUS T (FT) gene, which encodes a small, possibly mobile protein. A primary response to floral induction is the activation of FT RNA expression in leaves. Because flowers form at a distant site, the shoot apex, these data suggest that FT primarily controls the timing of flowering. Integration of temporal and spatial information is mediated in part by the bZIP transcription factor FD, which is already expressed at the shoot apex before floral induction. A complex of FT and FD proteins in turn can activate floral identity genes such as APETALA1 (AP1).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wigge, Philip A -- Kim, Min Chul -- Jaeger, Katja E -- Busch, Wolfgang -- Schmid, Markus -- Lohmann, Jan U -- Weigel, Detlef -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2005 Aug 12;309(5737):1056-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany. philip.wigge@bbsrc.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16099980" target="_blank"〉PubMed〈/a〉
    Keywords: Arabidopsis/genetics/*growth & development/*metabolism ; Arabidopsis Proteins/genetics/*metabolism ; Chromatin Immunoprecipitation ; DNA-Binding Proteins/genetics/metabolism ; Flowers/*growth & development ; Gene Expression Regulation, Plant ; Homeodomain Proteins/genetics/metabolism ; MADS Domain Proteins ; Models, Biological ; Mutation ; Oligonucleotide Array Sequence Analysis ; Phenotype ; Plant Leaves/metabolism ; Plant Proteins/genetics/metabolism ; Plant Shoots/metabolism ; Protein Interaction Mapping ; Recombinant Fusion Proteins/metabolism ; Signal Transduction ; Time Factors ; Transcription Factors/genetics/*metabolism ; Transcription, Genetic ; Two-Hybrid System Techniques
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 47
    Publication Date: 2005-10-22
    Description: Blood calcium concentration is maintained within a narrow range despite large variations in dietary input and body demand. The Transient Receptor Potential ion channel TRPV5 has been implicated in this process. We report here that TRPV5 is stimulated by the mammalian hormone klotho. Klotho, a beta-glucuronidase, hydrolyzes extracellular sugar residues on TRPV5, entrapping the channel in the plasma membrane. This maintains durable calcium channel activity and membrane calcium permeability in kidney. Thus, klotho activates a cell surface channel by hydrolysis of its extracellular N-linked oligosaccharides.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chang, Q -- Hoefs, S -- van der Kemp, A W -- Topala, C N -- Bindels, R J -- Hoenderop, J G -- New York, N.Y. -- Science. 2005 Oct 21;310(5747):490-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16239475" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/metabolism ; Calcium Channels/genetics/*metabolism ; Cell Line ; Cell Membrane/metabolism ; Cells, Cultured ; Glucuronidase/antagonists & inhibitors/metabolism ; Glycosylation ; Humans ; Hydrolysis ; Kidney/cytology/metabolism ; Membrane Proteins/*metabolism ; Mice ; Mice, Inbred C57BL ; Mutation ; Patch-Clamp Techniques ; Protein Transport ; Rabbits ; Sodium/metabolism ; TRPV Cation Channels/genetics/*metabolism ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 48
    Publication Date: 2005-11-15
    Description: Rapid global warming of 5 degrees to 10 degrees C during the Paleocene-Eocene Thermal Maximum (PETM) coincided with major turnover in vertebrate faunas, but previous studies have found little floral change. Plant fossils discovered in Wyoming, United States, show that PETM floras were a mixture of native and migrant lineages and that plant range shifts were large and rapid (occurring within 10,000 years). Floral composition and leaf shape and size suggest that climate warmed by approximately 5 degrees C during the PETM and that precipitation was low early in the event and increased later. Floral response to warming and/or increased atmospheric CO2 during the PETM was comparable in rate and magnitude to that seen in postglacial floras and to the predicted effects of anthropogenic carbon release and climate change on future vegetation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wing, Scott L -- Harrington, Guy J -- Smith, Francesca A -- Bloch, Jonathan I -- Boyer, Douglas M -- Freeman, Katherine H -- New York, N.Y. -- Science. 2005 Nov 11;310(5750):993-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Paleobiology, Smithsonian Museum of Natural History, 10th Street and Constitution Avenue, NW, Washington, DC 20560, USA. wings@si.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16284173" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biodiversity ; Carbon Isotopes/analysis ; *Climate ; *Ecosystem ; *Fossils ; Geologic Sediments ; *Greenhouse Effect ; Oxygen Isotopes/analysis ; Plant Development ; Plant Leaves/anatomy & histology ; *Plants/anatomy & histology/classification ; Rain ; Temperature ; Time Factors ; Wyoming
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 49
    Publication Date: 2005-07-30
    Description: The open oceans comprise most of the biosphere, yet patterns and trends of species diversity there are enigmatic. Here, we derive worldwide patterns of tuna and billfish diversity over the past 50 years, revealing distinct subtropical "hotspots" that appeared to hold generally for other predators and zooplankton. Diversity was positively correlated with thermal fronts and dissolved oxygen and a nonlinear function of temperature (approximately 25 degrees C optimum). Diversity declined between 10 and 50% in all oceans, a trend that coincided with increased fishing pressure, superimposed on strong El Nino-Southern Oscillation-driven variability across the Pacific. We conclude that predator diversity shows a predictable yet eroding pattern signaling ecosystem-wide changes linked to climate and fishing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Worm, Boris -- Sandow, Marcel -- Oschlies, Andreas -- Lotze, Heike K -- Myers, Ransom A -- New York, N.Y. -- Science. 2005 Aug 26;309(5739):1365-9. Epub 2005 Jul 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biology Department, Dalhousie University, Halifax, NS, Canada B3H 4J1. bworm@dal.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16051749" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biodiversity ; Climate ; *Ecosystem ; Fisheries ; Oceans and Seas ; Oxygen/analysis ; *Perciformes ; Population Density ; *Predatory Behavior ; Regression Analysis ; Seasons ; Temperature ; Time Factors ; *Tuna ; Zooplankton
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 50
    Publication Date: 2005-02-26
    Description: Determining what fraction of texts and manuscripts have survived from Antiquity and the Middle Ages has been highly problematic. Analyzing the transmission of texts as the "paleodemography" of their manuscripts yields definite and surprisingly high estimates. Parchment copies of the foremost medieval textbooks on arithmetical and calendrical calculation closely fit age distributions expected for populations with logistic growth and manuscripts with exponential survivorship. The estimated half-lives of copies agree with Bischoff's paleographically based suggestion that roughly one in seven manuscripts survive in some form from ninth-century Carolingian workshops. On this basis, many if not most of the leading technical titles circulating in Latin probably survived, even from late Antiquity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cisne, John L -- New York, N.Y. -- Science. 2005 Feb 25;307(5713):1305-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Earth and Atmospheric Sciences, Cornell University, Ithaca, NY 14853, USA. cisne@geology.cornell.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15731453" target="_blank"〉PubMed〈/a〉
    Keywords: History, 15th Century ; History, 16th Century ; History, Ancient ; History, Medieval ; Logistic Models ; Manuscripts as Topic/*history ; Markov Chains ; Mathematics ; Probability ; Science/*history ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 51
    Publication Date: 2005-04-30
    Description: The capacity to generate and analyze mental visual images is essential for many cognitive abilities. We combined triple-pulse transcranial magnetic stimulation (tpTMS) and repetitive TMS (rTMS) to determine which distinct aspect of mental imagery is carried out by the left and right parietal lobe and to reveal interhemispheric compensatory interactions. The left parietal lobe was predominant in generating mental images, whereas the right parietal lobe was specialized in the spatial comparison of the imagined content. Furthermore, in case of an rTMS-induced left parietal lesion, the right parietal cortex could immediately compensate such a left parietal disruption by taking over the specific function of the left hemisphere.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sack, A T -- Camprodon, J A -- Pascual-Leone, A -- Goebel, R -- K24 RR018875/RR/NCRR NIH HHS/ -- NCRR MO1 RR01032/RR/NCRR NIH HHS/ -- R01MH60734/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2005 Apr 29;308(5722):702-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cognitive Neuroscience, Faculty of Psychology, Maastricht University, Post Office Box 616, 6200 MD Maastricht, Netherlands. a.sack@psychology.unimaas.nl〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15860630" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Brain Mapping ; *Cognition ; Diagnostic Techniques, Neurological ; Functional Laterality ; Humans ; *Imagination ; Magnetics ; Male ; Parietal Lobe/*physiology ; Task Performance and Analysis ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 52
    Publication Date: 2005-02-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gilman, Sharon Larimer -- Glaze, Florence Eliza -- New York, N.Y. -- Science. 2005 Feb 25;307(5713):1208-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Coastal Carolina University, Conway, SC 29528, USA. sgilman@coastal.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15731431" target="_blank"〉PubMed〈/a〉
    Keywords: History, Ancient ; History, Medieval ; Logistic Models ; Manuscripts as Topic/*history ; Markov Chains ; Probability ; Science/*history ; Time Factors ; Translations
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 53
    Publication Date: 2005-11-15
    Description: The primary event that initiates vision is the light-induced 11-cis to all-trans isomerization of retinal in the visual pigment rhodopsin. Despite decades of study with the traditional tools of chemical reaction dynamics, both the timing and nature of the atomic motions that lead to photoproduct production remain unknown. We used femtosecond-stimulated Raman spectroscopy to obtain time-resolved vibrational spectra of the molecular structures formed along the reaction coordinate. The spectral evolution of the vibrational features from 200 femtoseconds to 1 picosecond after photon absorption reveals the temporal sequencing of the geometric changes in the retinal backbone that activate this receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kukura, Philipp -- McCamant, David W -- Yoon, Sangwoon -- Wandschneider, Daniel B -- Mathies, Richard A -- EY-02051/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 2005 Nov 11;310(5750):1006-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, University of California, Berkeley, CA 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16284176" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cattle ; Chemistry, Physical ; Energy Transfer ; Hydrogen/chemistry ; Isomerism ; *Light ; Models, Chemical ; Models, Molecular ; Photochemistry ; Photons ; Physicochemical Phenomena ; Protein Conformation ; Retinaldehyde/*chemistry ; Rhodopsin/*chemistry ; Spectrum Analysis, Raman ; Time Factors ; *Vision, Ocular
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 54
    Publication Date: 2005-12-13
    Description: Exciting though it may seem, the mathematical model developed by Cisne (Reports, 25 February 2005, p. 1305) to analyze the transmission of texts and manuscripts from Antiquity and the Middle Ages does not hold up to scrutiny. It seriously underestimates the losses, thus leading to conclusions that are unwarranted.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Declercq, Georges -- New York, N.Y. -- Science. 2005 Dec 9;310(5754):1618; author reply 1618.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of History, Vrije Universiteit Brussel, Pleinlaan 2, Brussels, B-1050, Belgium. georges.declercq@vub.ac.be〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16339431" target="_blank"〉PubMed〈/a〉
    Keywords: History, Ancient ; History, Medieval ; Libraries ; Logistic Models ; Manuscripts as Topic/*history ; Science/*history ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 55
    Publication Date: 2005-09-24
    Description: The contribution of language history to the study of the early dispersals of modern humans throughout the Old World has been limited by the shallow time depth (about 8000 +/- 2000 years) of current linguistic methods. Here it is shown that the application of biological cladistic methods, not to vocabulary (as has been previously tried) but to language structure (sound systems and grammar), may extend the time depths at which language data can be used. The method was tested against well-understood families of Oceanic Austronesian languages, then applied to the Papuan languages of Island Melanesia, a group of hitherto unrelatable isolates. Papuan languages show an archipelago-based phylogenetic signal that is consistent with the current geographical distribution of languages. The most plausible hypothesis to explain this result is the divergence of the Papuan languages from a common ancestral stock, as part of late Pleistocene dispersals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dunn, Michael -- Terrill, Angela -- Reesink, Ger -- Foley, Robert A -- Levinson, Stephen C -- New York, N.Y. -- Science. 2005 Sep 23;309(5743):2072-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max Planck Institute for Psycholinguistics, Post Office Box 310, 6500 AH Nijmegen, Netherlands. michael.dunn@mpi.nl〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16179483" target="_blank"〉PubMed〈/a〉
    Keywords: Asia ; *Cultural Evolution ; Databases, Factual ; History, Ancient ; Humans ; *Language ; *Linguistics ; Melanesia ; Pacific Islands ; Papua New Guinea ; Software ; Time Factors ; Vocabulary
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 56
    Publication Date: 2005-02-26
    Description: We identified axonal defects in mouse models of Alzheimer's disease that preceded known disease-related pathology by more than a year; we observed similar axonal defects in the early stages of Alzheimer's disease in humans. Axonal defects consisted of swellings that accumulated abnormal amounts of microtubule-associated and molecular motor proteins, organelles, and vesicles. Impairing axonal transport by reducing the dosage of a kinesin molecular motor protein enhanced the frequency of axonal defects and increased amyloid-beta peptide levels and amyloid deposition. Reductions in microtubule-dependent transport may stimulate proteolytic processing of beta-amyloid precursor protein, resulting in the development of senile plaques and Alzheimer's disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stokin, Gorazd B -- Lillo, Concepcion -- Falzone, Tomas L -- Brusch, Richard G -- Rockenstein, Edward -- Mount, Stephanie L -- Raman, Rema -- Davies, Peter -- Masliah, Eliezer -- Williams, David S -- Goldstein, Lawrence S B -- EY12598/EY/NEI NIH HHS/ -- EY13408/EY/NEI NIH HHS/ -- P50 AG05131/AG/NIA NIH HHS/ -- R01 EY007042/EY/NEI NIH HHS/ -- R01 EY007042-19/EY/NEI NIH HHS/ -- R01 EY013408/EY/NEI NIH HHS/ -- R01 EY013408-02/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 2005 Feb 25;307(5713):1282-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute and Department of Cellular and Molecular Medicine, School of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15731448" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Aged, 80 and over ; Alzheimer Disease/genetics/*metabolism/*pathology ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/metabolism ; Animals ; *Axonal Transport ; Axons/*pathology/physiology ; Basal Nucleus of Meynert/pathology ; Brain/*metabolism/*pathology ; Cells, Cultured ; Cytoplasmic Vesicles/ultrastructure ; Female ; Hippocampus ; Humans ; Kinesin/metabolism ; Male ; Mice ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Microtubule-Associated Proteins/genetics/metabolism ; Neurons/metabolism ; Organelles/ultrastructure ; Plaque, Amyloid/pathology ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 57
    Publication Date: 2005-08-05
    Description: Highly pathogenic avian influenza A (subtype H5N1) is threatening to cause a human pandemic of potentially devastating proportions. We used a stochastic influenza simulation model for rural Southeast Asia to investigate the effectiveness of targeted antiviral prophylaxis, quarantine, and pre-vaccination in containing an emerging influenza strain at the source. If the basic reproductive number (R0) was below 1.60, our simulations showed that a prepared response with targeted antivirals would have a high probability of containing the disease. In that case, an antiviral agent stockpile on the order of 100,000 to 1 million courses for treatment and prophylaxis would be sufficient. If pre-vaccination occurred, then targeted antiviral prophylaxis could be effective for containing strains with an R0 as high as 2.1. Combinations of targeted antiviral prophylaxis, pre-vaccination, and quarantine could contain strains with an R(0) as high as 2.4.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Longini, Ira M Jr -- Nizam, Azhar -- Xu, Shufu -- Ungchusak, Kumnuan -- Hanshaoworakul, Wanna -- Cummings, Derek A T -- Halloran, M Elizabeth -- R01-AI32042/AI/NIAID NIH HHS/ -- U01-GM070749/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2005 Aug 12;309(5737):1083-7. Epub 2005 Aug 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biostatistics, The Rollins School of Public Health, Emory University, 1518 Clifton Road, N.E., Atlanta, GA 30322, USA. longini@sph.emory.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16079251" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Antiviral Agents/*therapeutic use ; Asia, Southeastern/epidemiology ; Child ; Child, Preschool ; Disease Outbreaks/*prevention & control ; Humans ; Immunization Programs ; Infant ; *Influenza A virus/immunology ; *Influenza Vaccines ; Influenza, Human/epidemiology/*prevention & control/transmission/virology ; Models, Statistical ; *Quarantine ; Stochastic Processes ; Thailand/epidemiology ; Time Factors ; Vaccination
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 58
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-05-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- New York, N.Y. -- Science. 2005 May 27;308(5726):1235.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15919960" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Antiviral Agents ; *Biomedical Research ; Containment of Biohazards ; DNA, Recombinant ; Gene Transfer Techniques ; Russia ; Smallpox/drug therapy ; Smallpox Vaccine ; Time Factors ; United States ; *Variola virus/genetics ; World Health Organization
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 59
    Publication Date: 2005-11-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mai, Volker -- Stine, O Colin -- Morris, J Glenn Jr -- New York, N.Y. -- Science. 2005 Nov 18;310(5751):1118; author replay 1118.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16293741" target="_blank"〉PubMed〈/a〉
    Keywords: Bacteria/isolation & purification ; Colon/*microbiology ; Colonoscopy ; Feces/*microbiology ; Humans ; Intestinal Mucosa/microbiology ; Research Design ; Specimen Handling/*methods ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 60
    Publication Date: 2005-02-12
    Description: A major suspected bias in the fossil record of skeletonized groups is variation in preservability owing to differences in shell composition. However, despite extensive changes in shell composition over the 500-million-year history of marine bivalves, genus duration and shell composition show few significant relationships, and of those, virtually all are contrary to bias from preferential loss of highly reactive shell types. Distortion of large-scale temporal patterns in marine bivalves owing to preservability is thus apparently weak or randomly distributed, which increases the likelihood that observed patterns in this and other shelled groups carry a strong biological signal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kidwell, Susan M -- New York, N.Y. -- Science. 2005 Feb 11;307(5711):914-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Geophysical Sciences, University of Chicago, 5734 South Ellis Avenue, Chicago, IL 60637, USA. skidwell@uchicago.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15705849" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Calcium Carbonate/*analysis ; Databases, Factual ; *Fossils ; Mollusca/anatomy & histology/*chemistry/classification ; Species Specificity ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 61
    Publication Date: 2005-11-08
    Description: Understanding the brain computations leading to object recognition requires quantitative characterization of the information represented in inferior temporal (IT) cortex. We used a biologically plausible, classifier-based readout technique to investigate the neural coding of selectivity and invariance at the IT population level. The activity of small neuronal populations (approximately 100 randomly selected cells) over very short time intervals (as small as 12.5 milliseconds) contained unexpectedly accurate and robust information about both object "identity" and "category." This information generalized over a range of object positions and scales, even for novel objects. Coarse information about position and scale could also be read out from the same population.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hung, Chou P -- Kreiman, Gabriel -- Poggio, Tomaso -- DiCarlo, James J -- New York, N.Y. -- Science. 2005 Nov 4;310(5749):863-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉McGovern Institute for Brain Research, Cambridge, MA 02139, USA. chouhung@mit.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16272124" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Brain Mapping ; Macaca mulatta ; Neurons/*physiology ; Psychomotor Performance ; *Recognition (Psychology) ; Temporal Lobe/*physiology ; Time Factors ; *Visual Perception
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 62
    Publication Date: 2005-06-11
    Description: Removal of top predators from ecosystems can result in cascading effects through the trophic levels below, completely restructuring the food web. Cascades have been observed in small-scale or simple food webs, but not in large, complex, open-ocean ecosystems. Using data spanning many decades from a once cod-dominated northwest Atlantic ecosystem, we demonstrate a trophic cascade in a large marine ecosystem. Several cod stocks in other geographic areas have also collapsed without recovery, suggesting the existence of trophic cascades in these systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frank, Kenneth T -- Petrie, Brian -- Choi, Jae S -- Leggett, William C -- New York, N.Y. -- Science. 2005 Jun 10;308(5728):1621-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Fisheries and Oceans, Bedford Institute of Oceanography, Ocean Sciences Division, Post Office Box 1006, Dartmouth, Nova Scotia, B2Y 4A2, Canada. frankk@mar.dfo-mpo.gc.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15947186" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atlantic Ocean ; Biodiversity ; Biomass ; *Ecosystem ; Fisheries ; *Fishes ; *Food Chain ; Gadus morhua ; *Invertebrates ; *Phytoplankton ; Population Density ; Population Dynamics ; Predatory Behavior ; Principal Component Analysis ; Seals, Earless ; *Seawater ; Time Factors ; *Zooplankton
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 63
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-12-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2005 Dec 16;310(5755):1760-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16357240" target="_blank"〉PubMed〈/a〉
    Keywords: Diabetes Mellitus/*genetics ; *Diet ; *Epigenesis, Genetic ; *Family ; Fathers ; Female ; Food Supply ; Humans ; Life Style ; Male ; *Mortality ; Overweight/*genetics ; Risk Factors ; Sex Characteristics ; *Smoking ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 64
    Publication Date: 2005-05-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dale, V H -- Crisafulli, C M -- Swanson, F J -- New York, N.Y. -- Science. 2005 May 13;308(5724):961-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Oak Ridge National Laboratory, Oak Ridge, TN 37831-6036, USA. dalevh@ornl.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15890864" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biodiversity ; Birds ; Conservation of Natural Resources ; *Ecosystem ; Environment ; Fishes ; Food Chain ; Fresh Water ; Human Activities ; Soil ; Time Factors ; Trees ; *Volcanic Eruptions ; Washington
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 65
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-08-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Buringh, Eltjo -- New York, N.Y. -- Science. 2005 Jul 29;309(5735):698-701; author reply 698-701.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16060006" target="_blank"〉PubMed〈/a〉
    Keywords: History, Medieval ; Manuscripts as Topic/*history ; Mathematics ; Science/*history ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 66
    Publication Date: 2006-04-01
    Description: Quantifying long-range dissemination of infectious diseases is a key issue in their dynamics and control. Here, we use influenza-related mortality data to analyze the between-state progression of interpandemic influenza in the United States over the past 30 years. Outbreaks show hierarchical spatial spread evidenced by higher pairwise synchrony between more populous states. Seasons with higher influenza mortality are associated with higher disease transmission and more rapid spread than are mild ones. The regional spread of infection correlates more closely with rates of movement of people to and from their workplaces (workflows) than with geographical distance. Workflows are described in turn by a gravity model, with a rapid decay of commuting up to around 100 km and a long tail of rare longer range flow. A simple epidemiological model, based on the gravity formulation, captures the observed increase of influenza spatial synchrony with transmissibility; high transmission allows influenza to spread rapidly beyond local spatial constraints.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Viboud, Cecile -- Bjornstad, Ottar N -- Smith, David L -- Simonsen, Lone -- Miller, Mark A -- Grenfell, Bryan T -- New York, N.Y. -- Science. 2006 Apr 21;312(5772):447-51. Epub 2006 Mar 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA. viboudc@mail.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16574822" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Algorithms ; Child ; *Disease Outbreaks ; Hospitalization ; Humans ; Incidence ; *Influenza A Virus, H1N1 Subtype ; *Influenza A Virus, H3N2 Subtype ; *Influenza B virus ; Influenza, Human/*epidemiology/mortality/*transmission/virology ; Models, Statistical ; Population Density ; Seasons ; Stochastic Processes ; Time Factors ; Travel ; United States/epidemiology ; Workplace
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 67
    Publication Date: 2005-03-05
    Description: Environmental temperature is thought to be directly sensed by neurons through their projections in the skin. A subset of the mammalian transient receptor potential (TRP) family of ion channels has been implicated in this process. These "thermoTRPs" are activated at distinct temperature thresholds and are typically expressed in sensory neurons. TRPV3 is activated by heat (〉33 degrees C) and, unlike most thermoTRPs, is expressed in mouse keratinocytes. We found that TRPV3 null mice have strong deficits in responses to innocuous and noxious heat but not in other sensory modalities; hence, TRPV3 has a specific role in thermosensation. The natural compound camphor, which modulates sensations of warmth in humans, proved to be a specific activator of TRPV3. Camphor activated cultured primary keratinocytes but not sensory neurons, and this activity was abolished in TRPV3 null mice. Therefore, heat-activated receptors in keratinocytes are important for mammalian thermosensation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moqrich, Aziz -- Hwang, Sun Wook -- Earley, Taryn J -- Petrus, Matt J -- Murray, Amber N -- Spencer, Kathryn S R -- Andahazy, Mary -- Story, Gina M -- Patapoutian, Ardem -- New York, N.Y. -- Science. 2005 Mar 4;307(5714):1468-72.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15746429" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bradykinin/pharmacology ; CHO Cells ; Camphor/pharmacology ; Cation Transport Proteins/genetics/*physiology ; Cells, Cultured ; Cricetinae ; Dermis/anatomy & histology/innervation/ultrastructure ; Epidermis/anatomy & histology/innervation/ultrastructure ; Ganglia, Spinal/cytology/metabolism ; *Hot Temperature ; Humans ; Ion Channels/genetics/*physiology ; Keratinocytes/*metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neurons, Afferent/physiology ; Patch-Clamp Techniques ; TRPV Cation Channels ; Temperature ; Thermoreceptors/*physiology ; *Thermosensing ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 68
    Publication Date: 2005-02-26
    Description: Shigella, the leading cause of bacillary dysentery, uses a type III secretion system (TTSS) to inject proteins into human cells, leading to bacterial invasion and a vigorous inflammatory response. The bacterium is protected against the response by the O antigen of lipopolysaccharide (LPS) on its surface. We show that bacteriophage-encoded glucosylation of Shigella O antigen, the basis of different serotypes, shortens the LPS molecule by around half. This enhances TTSS function without compromising the protective properties of the LPS. Thus, LPS glucosylation promotes bacterial invasion and evasion of innate immunity, which may have contributed to the emergence of serotype diversity in Shigella.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉West, Nicholas P -- Sansonetti, Philippe -- Mounier, Joelle -- Exley, Rachel M -- Parsot, Claude -- Guadagnini, Stephanie -- Prevost, Marie-Christine -- Prochnicka-Chalufour, Ada -- Delepierre, Muriel -- Tanguy, Myriam -- Tang, Christoph M -- New York, N.Y. -- Science. 2005 Feb 25;307(5713):1313-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Molecular Microbiology and Infection, Department of Infectious Diseases, Faculty of Medicine, Flowers Building, Imperial College London, London SW7 2AZ, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15731456" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacterial Adhesion ; Bacteriophages/genetics ; Carbohydrate Conformation ; Dysentery, Bacillary/immunology/*microbiology/pathology ; Glucose/*metabolism ; Glycosylation ; Hydrophobic and Hydrophilic Interactions ; Immunity, Innate ; Intestinal Mucosa/microbiology/pathology ; Lipopolysaccharides/chemistry/*metabolism ; Microscopy, Electron, Scanning ; Microscopy, Electron, Transmission ; Mutation ; Neutrophils ; O Antigens/chemistry/*metabolism ; Operon ; Rabbits ; Serotyping ; Shigella flexneri/classification/metabolism/*pathogenicity/ultrastructure ; Virulence
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 69
    Publication Date: 2005-07-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pyenson, Nicholas D -- Pyenson, Lewis -- New York, N.Y. -- Science. 2005 Jul 29;309(5735):698-701; author reply 698-701.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16051771" target="_blank"〉PubMed〈/a〉
    Keywords: History, Medieval ; Manuscripts as Topic/*history ; Science/*history ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 70
    Publication Date: 2005-05-28
    Description: MicroRNAs (miRNAs) are small noncoding RNAs, about 21 nucleotides in length, that can regulate gene expression by base-pairing to partially complementary mRNAs. Regulation by miRNAs can play essential roles in embryonic development. We determined the temporal and spatial expression patterns of 115 conserved vertebrate miRNAs in zebrafish embryos by microarrays and by in situ hybridizations, using locked-nucleic acid-modified oligonucleotide probes. Most miRNAs were expressed in a highly tissue-specific manner during segmentation and later stages, but not early in development, which suggests that their role is not in tissue fate establishment but in differentiation or maintenance of tissue identity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wienholds, Erno -- Kloosterman, Wigard P -- Miska, Eric -- Alvarez-Saavedra, Ezequiel -- Berezikov, Eugene -- de Bruijn, Ewart -- Horvitz, H Robert -- Kauppinen, Sakari -- Plasterk, Ronald H A -- New York, N.Y. -- Science. 2005 Jul 8;309(5732):310-1. Epub 2005 May 26.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Hubrecht Laboratory, Centre for Biomedical Genetics, 3584 CT Utrecht, the Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15919954" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blotting, Northern ; Embryo, Nonmammalian/*metabolism ; Embryonic Development ; *Gene Expression ; In Situ Hybridization ; MicroRNAs/*genetics/*metabolism ; Multigene Family ; Oligonucleotide Array Sequence Analysis ; Oligonucleotide Probes ; Organ Specificity ; Time Factors ; Zebrafish/*embryology/*genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 71
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-11-15
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2767379/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2767379/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Champion, Paul M -- R01 DK035090/DK/NIDDK NIH HHS/ -- R01 DK035090-23/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2005 Nov 11;310(5750):980-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Physics Department and the Center for Interdisciplinary Research on Complex Systems, Northeastern University, Boston, MA 02115, USA. p.champion@neu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16284167" target="_blank"〉PubMed〈/a〉
    Keywords: Chemistry, Physical ; Electrons ; Energy Transfer ; Hydrogen/chemistry ; Isomerism ; *Light ; Photochemistry ; Physicochemical Phenomena ; Protein Conformation ; Retinaldehyde/chemistry ; Rhodopsin/*chemistry ; Spectrum Analysis, Raman ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 72
    Publication Date: 2005-03-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hewitt, Sylvia Curtis -- Deroo, Bonnie J -- Korach, Kenneth S -- New York, N.Y. -- Science. 2005 Mar 11;307(5715):1572-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15761144" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Membrane/*metabolism ; Endoplasmic Reticulum/*metabolism ; Estradiol/*analogs & derivatives/metabolism ; Estrogen Receptor alpha/metabolism ; Estrogens/*metabolism ; Gene Expression Regulation ; Humans ; Models, Biological ; Receptors, Estrogen/chemistry/*metabolism ; Receptors, G-Protein-Coupled/*metabolism ; *Signal Transduction ; Tamoxifen/metabolism ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 73
    Publication Date: 2005-07-05
    Description: Using an active approach to preventing biofilm formation, we implemented a microfluidic bioreactor that enables long-term culture and monitoring of extremely small populations of bacteria with single-cell resolution. We used this device to observe the dynamics of Escherichia coli carrying a synthetic "population control" circuit that regulates cell density through a feedback mechanism based on quorum sensing. The microfluidic bioreactor enabled long-term monitoring of unnatural behavior programmed by the synthetic circuit, which included sustained oscillations in cell density and associated morphological changes, over hundreds of hours.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Balagadde, Frederick K -- You, Lingchong -- Hansen, Carl L -- Arnold, Frances H -- Quake, Stephen R -- New York, N.Y. -- Science. 2005 Jul 1;309(5731):137-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Applied Physics, California Institute of Technology, Pasadena, CA 91125, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15994559" target="_blank"〉PubMed〈/a〉
    Keywords: 4-Butyrolactone/*analogs & derivatives/biosynthesis/metabolism ; *Bacteriological Techniques ; Biofilms/growth & development ; *Bioreactors ; Colony Count, Microbial ; Computer Simulation ; Culture Media ; Escherichia coli/cytology/genetics/*growth & development/physiology ; Feedback, Physiological ; Genes, Bacterial ; Isopropyl Thiogalactoside/pharmacology ; Mathematics ; Microfluidics ; Models, Biological ; Mutation ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 74
    Publication Date: 2005-02-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Normark, Staffan -- Nilsson, Christina -- Normark, Birgitta Henriques -- New York, N.Y. -- Science. 2005 Feb 25;307(5713):1211-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, 171 77, Sweden. staffan.normark@stratresearch.se〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15731433" target="_blank"〉PubMed〈/a〉
    Keywords: Adhesins, Bacterial/chemistry/*metabolism ; Animals ; Bacterial Proteins/metabolism ; Bacteriophages/genetics ; Carbohydrate Conformation ; Cell Membrane/microbiology ; Dysentery, Bacillary/*microbiology ; Glucose/metabolism ; Glycosylation ; Lipopolysaccharides/chemistry/*metabolism ; Models, Biological ; Mutation ; O Antigens/chemistry/*metabolism ; Operon ; Rabbits ; Serotyping ; Shigella flexneri/classification/genetics/metabolism/*pathogenicity ; Virulence ; Virulence Factors/metabolism ; Yersinia enterocolitica/metabolism/*pathogenicity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 75
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-10-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roberts, Leslie -- New York, N.Y. -- Science. 2005 Oct 14;310(5746):213.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16223994" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Infant ; Minnesota/epidemiology ; Mutation ; Poliomyelitis/*epidemiology/etiology/virology ; Poliovirus/classification/genetics/*isolation & purification ; Poliovirus Vaccine, Oral/*adverse effects ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 76
    Publication Date: 2005-06-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barbi, Elisabetta -- Vaupel, James W -- New York, N.Y. -- Science. 2005 Jun 17;308(5729):1743; author reply 1743.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Statistics, University of Messina,Via dei Verdi 58, 98100 Messina, Italy.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15961654" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Child ; Cohort Studies ; Humans ; Infant ; Infant Mortality ; Infection/epidemiology ; *Inflammation/epidemiology ; Italy ; *Life Expectancy ; Longevity ; *Mortality ; Sweden ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 77
    Publication Date: 2005-07-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ice, Ryan J -- Wildonger, Jill -- Mann, Richard S -- Hiebert, Scott W -- CA64140/CA/NCI NIH HHS/ -- CA87379/CA/NCI NIH HHS/ -- R01 CA087379/CA/NCI NIH HHS/ -- R01 GM058575/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2005 Jul 22;309(5734):558; author reply 558.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16040690" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Proteins, Signal Transducing/*analysis/genetics/immunology ; Animals ; Antibodies/*immunology ; Antibody Specificity ; Axons/chemistry ; COS Cells ; Cell Membrane/chemistry ; Cell Nucleus/*chemistry ; Cross Reactions ; Cyclic AMP-Dependent Protein Kinases/metabolism ; DNA-Binding Proteins/immunology ; Drosophila/chemistry/*embryology/genetics/metabolism ; Drosophila Proteins/*analysis/genetics/immunology ; Epitopes ; Fluorescent Antibody Technique ; Immunoblotting ; Immunoprecipitation ; Mutation ; Neurons/*chemistry/ultrastructure ; RNA, Messenger/analysis/genetics ; Rabbits ; Semaphorins/metabolism ; Transcription Factors/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 78
    Publication Date: 2005-07-16
    Description: We report direct structural evidence of the bridged radical (CH2ICH2.) in a polar solution, obtained using time-resolved liquid-phase x-ray diffraction. This transient intermediate has long been hypothesized to explain stereo-chemical control in many association and/or dissociation reactions involving haloalkanes. Ultrashort optical pulses were used to dissociate an iodine atom from the haloethane molecule (C2H4I2) dissolved in methanol, and the diffraction of picosecond x-ray pulses from a synchrotron supports the following structural dynamics, with approximately 0.01 angstrom spatial resolution and approximately 100 picosecond time resolution: The loss of one iodine atom from C2H4I2 leads to the C-I-C triangular geometry of CH2ICH2.. This transient C2H4I then binds to an iodine atom to form a new species, the C2H4I-I isomer, which eventually decays into C2H4 + I2. Solvent dynamics were also extracted from the data, revealing a change in the solvent cage geometry, heating, and thermal expansion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ihee, H -- Lorenc, M -- Kim, T K -- Kong, Q Y -- Cammarata, M -- Lee, J H -- Bratos, S -- Wulff, M -- New York, N.Y. -- Science. 2005 Aug 19;309(5738):1223-7. Epub 2005 Jul 14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and School of Molecular Science (BK21), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, Republic of Korea. hyotcherl.ihee@kaist.ac.kr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16020695" target="_blank"〉PubMed〈/a〉
    Keywords: Computer Simulation ; Free Radicals ; Hydrocarbons, Iodinated/*chemistry ; Isomerism ; Methanol/chemistry ; Molecular Structure ; Scattering, Radiation ; Solutions ; Solvents/chemistry ; Synchrotrons ; Temperature ; Thermodynamics ; Time Factors ; X-Ray Diffraction/*methods ; X-Rays
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 79
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-02-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2005 Feb 25;307(5713):1185.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15731415" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/virology ; Anti-HIV Agents/*pharmacology/therapeutic use ; CD4 Lymphocyte Count ; Disease Progression ; Drug Resistance, Multiple, Viral ; HIV/*drug effects/*pathogenicity ; HIV Infections/drug therapy/*physiopathology/transmission/*virology ; Humans ; Male ; Time Factors ; Virulence
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 80
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-06-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2005 Jun 10;308(5728):1534-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15947149" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Astrocytes/cytology/physiology ; Cell Culture Techniques ; Cell Differentiation ; Cell Line ; Cell Survival ; *Clinical Trials, Phase I as Topic ; Embryo, Mammalian/*cytology ; Humans ; Mice ; Mice, Nude ; Mutation ; Myelin Sheath/physiology ; Neurons/cytology/physiology ; *Oligodendroglia/cytology/physiology ; Rats ; Spinal Cord Injuries/*therapy ; *Stem Cell Transplantation/adverse effects ; *Stem Cells/cytology/physiology ; Teratoma/etiology ; Time Factors ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 81
    Publication Date: 2005-05-14
    Description: We show that the distributions of both exploited and nonexploited North Sea fishes have responded markedly to recent increases in sea temperature, with nearly two-thirds of species shifting in mean latitude or depth or both over 25 years. For species with northerly or southerly range margins in the North Sea, half have shown boundary shifts with warming, and all but one shifted northward. Species with shifting distributions have faster life cycles and smaller body sizes than nonshifting species. Further temperature rises are likely to have profound impacts on commercial fisheries through continued shifts in distribution and alterations in community interactions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perry, Allison L -- Low, Paula J -- Ellis, Jim R -- Reynolds, John D -- New York, N.Y. -- Science. 2005 Jun 24;308(5730):1912-5. Epub 2005 May 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Ecology, Evolution and Conservation, School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK. a.perry@uea.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15890845" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Body Size ; *Climate ; *Ecosystem ; Environment ; Fisheries ; *Fishes/anatomy & histology/growth & development ; North Sea ; Population Density ; Population Dynamics ; *Seawater ; Temperature ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 82
    Publication Date: 2006-05-06
    Description: Given the choice of waiting for an adverse outcome or getting it over with quickly, many people choose the latter. Theoretical models of decision-making have assumed that this occurs because there is a cost to waiting-i.e., dread. Using functional magnetic resonance imaging, we measured the neural responses to waiting for a cutaneous electric shock. Some individuals dreaded the outcome so much that, when given a choice, they preferred to receive more voltage rather than wait. Even when no decision was required, these extreme dreaders were distinguishable from those who dreaded mildly by the rate of increase of neural activity in the posterior elements of the cortical pain matrix. This suggests that dread derives, in part, from the attention devoted to the expected physical response and not simply from fear or anxiety. Although these differences were observed during a passive waiting procedure, they correlated with individual behavior in a subsequent choice paradigm, providing evidence for a neurobiological link between the experienced disutility of dread and subsequent decisions about unpleasant outcomes.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1820741/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1820741/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berns, Gregory S -- Chappelow, Jonathan -- Cekic, Milos -- Zink, Caroline F -- Pagnoni, Giuseppe -- Martin-Skurski, Megan E -- DA00367/DA/NIDA NIH HHS/ -- DA016434/DA/NIDA NIH HHS/ -- K08 DA000367/DA/NIDA NIH HHS/ -- R01 DA016434/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 2006 May 5;312(5774):754-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Suite 4000, Atlanta, GA 30322, USA. gberns@emory.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16675703" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Anxiety ; Brain Mapping ; Cerebral Cortex/*physiology ; Cues ; *Decision Making ; Electroshock ; *Emotions ; *Fear ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Models, Psychological ; Pain/physiopathology ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 83
    Publication Date: 2006-09-23
    Description: Protein aggregation is an established pathogenic mechanism in Alzheimer's disease, but little is known about the initiation of this process in vivo. Intracerebral injection of dilute, amyloid-beta (Abeta)-containing brain extracts from humans with Alzheimer's disease or beta-amyloid precursor protein (APP) transgenic mice induced cerebral beta-amyloidosis and associated pathology in APP transgenic mice in a time- and concentration-dependent manner. The seeding activity of brain extracts was reduced or abolished by Abeta immunodepletion, protein denaturation, or by Abeta immunization of the host. The phenotype of the exogenously induced amyloidosis depended on both the host and the source of the agent, suggesting the existence of polymorphic Abeta strains with varying biological activities reminiscent of prion strains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meyer-Luehmann, Melanie -- Coomaraswamy, Janaky -- Bolmont, Tristan -- Kaeser, Stephan -- Schaefer, Claudia -- Kilger, Ellen -- Neuenschwander, Anton -- Abramowski, Dorothee -- Frey, Peter -- Jaton, Anneliese L -- Vigouret, Jean-Marie -- Paganetti, Paolo -- Walsh, Dominic M -- Mathews, Paul M -- Ghiso, Jorge -- Staufenbiel, Matthias -- Walker, Lary C -- Jucker, Mathias -- NS45357/NS/NINDS NIH HHS/ -- RR-00165/RR/NCRR NIH HHS/ -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2006 Sep 22;313(5794):1781-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tubingen, D-72076 Tubingen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16990547" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Aged, 80 and over ; Aging ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/*administration & dosage/*analysis/chemistry/pharmacology ; Amyloid beta-Protein Precursor/*administration & dosage/pharmacology ; Amyloidosis/*metabolism/pathology ; Animals ; Brain/pathology ; Brain Chemistry ; Brain Diseases/*metabolism/pathology ; Female ; Hippocampus/*chemistry/pathology ; Humans ; Male ; Mice ; Mice, Transgenic ; Protein Denaturation ; Time Factors ; Tissue Extracts
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 84
    Publication Date: 2006-01-28
    Description: Directly transmitted parasites often provide substantial information about the temporal and spatial characteristics of host-to-host contact. Here, we demonstrate that a fast-evolving virus (feline immunodeficiency virus, FIV) can reveal details of the contemporary population structure and recent demographic history of its natural wildlife host (Puma concolor) that were not apparent from host genetic data and would be impossible to obtain by other means. We suggest that rapidly evolving pathogens may provide a complementary tool for studying population dynamics of their hosts in "shallow" time.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Biek, Roman -- Drummond, Alexei J -- Poss, Mary -- New York, N.Y. -- Science. 2006 Jan 27;311(5760):538-41.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wildlife Biology Program, University of Montana, Missoula, MT 59812, USA. rbiek@emory.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16439664" target="_blank"〉PubMed〈/a〉
    Keywords: Alberta/epidemiology ; Animals ; Bayes Theorem ; British Columbia/epidemiology ; Ecosystem ; *Evolution, Molecular ; Genes, env ; Genes, pol ; Geography ; Immunodeficiency Virus, Feline/*classification/*genetics ; Lentivirus Infections/epidemiology/*veterinary/virology ; Microsatellite Repeats ; Molecular Sequence Data ; Montana/epidemiology ; Phylogeny ; Population Dynamics ; *Puma/genetics/virology ; Time Factors ; Wyoming/epidemiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 85
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2006-02-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2006 Feb 10;311(5762):755.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16469884" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Breast Neoplasms/*epidemiology/prevention & control ; Cardiovascular Diseases/*epidemiology/prevention & control ; Colorectal Neoplasms/*epidemiology/prevention & control ; *Diet, Fat-Restricted ; Female ; Humans ; Randomized Controlled Trials as Topic ; Research Design ; Risk ; Surveys and Questionnaires ; Time Factors ; United States/epidemiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 86
    Publication Date: 2006-04-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, Greg -- New York, N.Y. -- Science. 2006 Mar 31;311(5769):1851.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16574834" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Cerebral Cortex/*anatomy & histology/*growth & development ; Child ; Child, Preschool ; Humans ; *Intelligence ; Intelligence Tests ; Magnetic Resonance Imaging ; Organ Size ; Prefrontal Cortex/*anatomy & histology/*growth & development ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 87
    Publication Date: 2006-03-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Glickman, Seth W -- Rasiel, Emma B -- Hamilton, Carol Dukes -- Kubataev, Arsen -- Schulman, Kevin A -- New York, N.Y. -- Science. 2006 Mar 3;311(5765):1246-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Health Sector Management Program, Fuqua School of Business, Duke University, Durham, NC 27708, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16513969" target="_blank"〉PubMed〈/a〉
    Keywords: Antitubercular Agents/*therapeutic use ; Clinical Trials as Topic/economics ; Computer Simulation ; Costs and Cost Analysis ; *Drug Approval/economics ; Drug Evaluation, Preclinical/economics ; Drug Industry ; Humans ; Monte Carlo Method ; National Institutes of Health (U.S.) ; Private Sector ; Probability ; Public Sector ; Time Factors ; Tuberculosis/*drug therapy ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 88
    Publication Date: 2006-01-18
    Description: In contrast to current models, fluorescence resonance energy transfer measurements using a single-cell imaging assay with fluorescent forms of PER and TIM showed that these proteins bind rapidly and persist in the cytoplasm while gradually accumulating in discrete foci. After approximately 6 hours, complexes abruptly dissociated, as PER and TIM independently moved to the nucleus in a narrow time frame. The per(L) mutation delayed nuclear accumulation in vivo and in our cultured cell system, but without affecting rates of PER/TIM assembly or dissociation. This finding points to a previously unrecognized form of temporal regulation that underlies the periodicity of the circadian clock.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meyer, Pablo -- Saez, Lino -- Young, Michael W -- GM54339/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2006 Jan 13;311(5758):226-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16410523" target="_blank"〉PubMed〈/a〉
    Keywords: Active Transport, Cell Nucleus ; Animals ; Cell Line ; Cell Nucleus/metabolism ; Circadian Rhythm/*physiology ; Cytoplasm/metabolism ; Drosophila Proteins/*metabolism ; Drosophila melanogaster ; Fluorescence Resonance Energy Transfer ; Models, Biological ; Nuclear Proteins/*metabolism ; Period Circadian Proteins ; Protein Binding ; Recombinant Fusion Proteins/metabolism ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 89
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2006-09-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2006 Sep 22;313(5794):1715-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16990522" target="_blank"〉PubMed〈/a〉
    Keywords: *Bone Marrow Transplantation ; Controlled Clinical Trials as Topic ; Heart/*physiopathology ; Humans ; Myocardial Infarction/physiopathology/*therapy ; Stroke Volume ; Time Factors ; *Ventricular Function, Left
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 90
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2006-03-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, Michael S -- Goldstein, Joseph L -- New York, N.Y. -- Science. 2006 Mar 24;311(5768):1721-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9046, USA. mike.brown@utsouthwestern.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16556829" target="_blank"〉PubMed〈/a〉
    Keywords: African Americans/genetics ; Animals ; Anticholesteremic Agents/*therapeutic use ; Cholesterol, LDL/*blood ; Codon, Nonsense ; Coronary Disease/epidemiology/genetics/*prevention & control ; Diet, Fat-Restricted ; European Continental Ancestry Group/genetics ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Incidence ; Lipoproteins, LDL/*blood ; Mice ; Mutation, Missense ; Proprotein Convertases ; Serine Endopeptidases/*genetics/*metabolism ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 91
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2006-07-15
    Description: Competitor species can have evolutionary effects on each other that result in ecological character displacement; that is, divergence in resource-exploiting traits such as jaws and beaks. Nevertheless, the process of character displacement occurring in nature, from the initial encounter of competitors to the evolutionary change in one or more of them, has not previously been investigated. Here we report that a Darwin's finch species (Geospiza fortis) on an undisturbed Galapagos island diverged in beak size from a competitor species (G. magnirostris) 22 years after the competitor's arrival, when they jointly and severely depleted the food supply. The observed evolutionary response to natural selection was the strongest recorded in 33 years of study, and close to the value predicted from the high heritability of beak size. These findings support the role of competition in models of community assembly, speciation, and adaptive radiations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grant, Peter R -- Grant, B Rosemary -- New York, N.Y. -- Science. 2006 Jul 14;313(5784):224-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544-1003, USA. prgrant@princeton.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16840700" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Beak/*anatomy & histology ; *Biological Evolution ; Biomass ; Body Size ; Competitive Behavior ; Disasters ; Ecosystem ; Ecuador ; Feeding Behavior ; Female ; *Finches/anatomy & histology/physiology ; *Food ; Male ; Organ Size ; Population Density ; Population Dynamics ; *Seeds ; *Selection, Genetic ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 92
    Publication Date: 2006-02-25
    Description: Since the 1990s, phytoplankton biomass on the continental shelf of Nova Scotia and in the Labrador Sea has undergone sustained changes in the spring and fall, which are accompanied by changes in bacterioplankton that are dampened in amplitude but coherent in the direction of change. A reversal of trend in biomass change, so-called sign switching, occurs both in time and in space. Thus, whenever (spring or fall) and wherever (Scotian Shelf or Labrador Sea) phytoplankton increase or decrease, so also does bacterioplankton. This tandem sign switch indicates coupling of the trophic levels at a multiyear time scale and contributes to an ecological fingerprint of systemwide forcing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, William K W -- Harrison, W Glen -- Head, Erica J H -- New York, N.Y. -- Science. 2006 Feb 24;311(5764):1157-60.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Bedford Institute of Oceanography, P.O. Box 1006, Dartmouth, Nova Scotia B2Y 4A2, Canada. LiB@mar.dfo-mpo.gc.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16497934" target="_blank"〉PubMed〈/a〉
    Keywords: Atlantic Ocean ; Bacteria/*growth & development ; Biomass ; Chlorophyll/analysis ; *Ecosystem ; Phytoplankton/*growth & development ; Plankton/*growth & development ; Seasons ; Seawater/*microbiology ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 93
    Publication Date: 2006-09-09
    Description: Humans and animals can nonverbally enumerate visual items across time in a sequence or rapidly estimate the set size of spatial dot patterns at a single glance. We found that temporal and spatial enumeration processes engaged different populations of neurons in the intraparietal sulcus of behaving monkeys. Once the enumeration process was completed, however, another neuronal population represented the cardinality of a set irrespective of whether it had been cued in a spatial layout or across time. These data suggest distinct neural processing stages for different numerical formats, but also a final convergence of the segregated information to form most abstract quantity representations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nieder, Andreas -- Diester, Ilka -- Tudusciuc, Oana -- New York, N.Y. -- Science. 2006 Sep 8;313(5792):1431-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Primate NeuroCognition Laboratory, Hertie-Institute for Clinical Brain Research, Department of Cognitive Neurology, University of Tubingen, Otfried-Muller-Strasse 27, 72076 Tubingen, Germany. andreas.nieder@uni-tuebingen.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16960005" target="_blank"〉PubMed〈/a〉
    Keywords: Analysis of Variance ; Animals ; Brain Mapping ; *Discrimination (Psychology) ; Electrophysiology ; Macaca mulatta ; *Mathematics ; *Mental Processes ; Neurons/*physiology ; Parietal Lobe/*physiology ; Regression Analysis ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 94
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2006-07-11
    Description: Prions are thought to be the proteinaceous infectious agents responsible for transmissible spongiform encephalopathies (TSEs). PrP(Sc), the main component of the infectious agent, is also the only validated surrogate marker for the disease, and its sensitive detection is critical for minimizing the spread of the disease. We detected PrP(Sc) biochemically in the blood of hamsters infected with scrapie during most of the presymptomatic phase of the disease. At early stages of the incubation period, PrP(Sc) detected in blood was likely to be from the peripheral replication of prions, whereas at the symptomatic phase, PrP(Sc) in blood was more likely to have leaked from the brain. The ability to detect prions biochemically in the blood of infected but not clinically sick animals offers a great promise for the noninvasive early diagnosis of TSEs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Saa, Paula -- Castilla, Joaquin -- Soto, Claudio -- AG0224642/AG/NIA NIH HHS/ -- NS049173/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2006 Jul 7;313(5783):92-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉George and Cynthia Mitchell Center for Alzheimer's Disease Research, Department of Neurology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0646, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16825570" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood-Brain Barrier ; Brain Chemistry ; Creutzfeldt-Jakob Syndrome/blood/diagnosis ; Cricetinae ; Humans ; Lymphocytes/chemistry ; Lymphoid Tissue/chemistry ; Mesocricetus ; PrPSc Proteins/*blood/chemistry ; Protein Folding ; Scrapie/*blood/*diagnosis ; Sensitivity and Specificity ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 95
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2006-01-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dunlap, Jay C -- R01 GM034985/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2006 Jan 13;311(5758):184-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA. jay.c.dunlap@dartmouth.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16410512" target="_blank"〉PubMed〈/a〉
    Keywords: Active Transport, Cell Nucleus ; Animals ; Cell Nucleus/metabolism ; Circadian Rhythm/*physiology ; Drosophila Proteins/*metabolism ; Drosophila melanogaster ; Gene Expression Regulation ; Models, Biological ; Nuclear Proteins/*metabolism ; Period Circadian Proteins ; Protein Binding ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 96
    Publication Date: 2006-10-21
    Description: A magnetic resonance approach is presented that enables high-sensitivity, high-contrast molecular imaging by exploiting xenon biosensors. These sensors link xenon atoms to specific biomolecular targets, coupling the high sensitivity of hyperpolarized nuclei with the specificity of biochemical interactions. We demonstrated spatial resolution of a specific target protein in vitro at micromolar concentration, with a readout scheme that reduces the required acquisition time by 〉3300-fold relative to direct detection. This technique uses the signal of free hyperpolarized xenon to dramatically amplify the sensor signal via chemical exchange saturation transfer (CEST). Because it is approximately 10,000 times more sensitive than previous CEST methods and other molecular magnetic resonance imaging techniques, it marks a critical step toward the application of xenon biosensors as selective contrast agents in biomedical applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schroder, Leif -- Lowery, Thomas J -- Hilty, Christian -- Wemmer, David E -- Pines, Alexander -- New York, N.Y. -- Science. 2006 Oct 20;314(5798):446-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, University of California, Berkeley, CA 94720, USA. dewemmer@lbl.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17053143" target="_blank"〉PubMed〈/a〉
    Keywords: Avidin ; *Biosensing Techniques ; Biotin ; Contrast Media ; Magnetic Resonance Imaging/*methods ; Magnetic Resonance Spectroscopy/*methods ; Microspheres ; Sensitivity and Specificity ; Sepharose ; Time Factors ; *Xenon Isotopes
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 97
    Publication Date: 2006-09-02
    Description: Comparisons of recent with historical samples of chromosome inversion frequencies provide opportunities to determine whether genetic change is tracking climate change in natural populations. We determined the magnitude and direction of shifts over time (24 years between samples on average) in chromosome inversion frequencies and in ambient temperature for populations of the fly Drosophila subobscura on three continents. In 22 of 26 populations, climates warmed over the intervals, and genotypes characteristic of low latitudes (warm climates) increased in frequency in 21 of those 22 populations. Thus, genetic change in this fly is tracking climate warming and is doing so globally.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Balanya, Joan -- Oller, Josep M -- Huey, Raymond B -- Gilchrist, George W -- Serra, Luis -- New York, N.Y. -- Science. 2006 Sep 22;313(5794):1773-5. Epub 2006 Aug 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Faculty of Biology, University of Barcelona, Diagonal 645, Barcelona 08071, Spain. jbalanya@ub.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16946033" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Chromosome Inversion ; *Climate ; Drosophila/*genetics ; Europe ; Female ; Genome, Insect ; Geography ; Greenhouse Effect ; Male ; South America ; Temperature ; Time Factors ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 98
    Publication Date: 2006-08-26
    Description: Analogous to learning and memory storage, long-term potentiation (LTP) is divided into induction and maintenance phases. Testing the hypothesis that the mechanism of LTP maintenance stores information requires reversing this mechanism in vivo and finding out whether long-term stored information is lost. This was not previously possible. Recently however, persistent phosphorylation by the atypical protein kinase C isoform, protein kinase Mzeta (PKMz), has been found to maintain late LTP in hippocampal slices. Here we show that a cell-permeable PKMz inhibitor, injected in the rat hippocampus, both reverses LTP maintenance in vivo and produces persistent loss of 1-day-old spatial information. Thus, the mechanism maintaining LTP sustains spatial memory.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pastalkova, Eva -- Serrano, Peter -- Pinkhasova, Deana -- Wallace, Emma -- Fenton, Andre Antonio -- Sacktor, Todd Charlton -- MH57068/MH/NIMH NIH HHS/ -- R01 MH53576/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2006 Aug 25;313(5790):1141-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Physiology, Pharmacology, and Neurology, Robert F. Furchgott Center for Neural and Behavioral Science, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16931766" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Avoidance Learning ; Conditioning (Psychology) ; Dentate Gyrus/drug effects/physiology ; Electric Stimulation ; Excitatory Postsynaptic Potentials/drug effects ; Heat-Shock Proteins/administration & dosage/pharmacology ; Hippocampus/drug effects/*physiology ; Long-Term Potentiation/drug effects/*physiology ; Male ; Memory/drug effects/*physiology ; Perforant Pathway ; Protein Kinase C/antagonists & inhibitors/metabolism ; Rats ; Rats, Long-Evans ; Staurosporine/pharmacology ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 99
    Publication Date: 2007-08-19
    Description: Little is known about the neuronal mechanisms that subserve long-term memory persistence in the brain. The components of the remodeled synaptic machinery, and how they sustain the new synaptic or cellwide configuration over time, are yet to be elucidated. In the rat cortex, long-term associative memories vanished rapidly after local application of an inhibitor of the protein kinase C isoform, protein kinase M zeta (PKMzeta). The effect was observed for at least several weeks after encoding and may be irreversible. In the neocortex, which is assumed to be the repository of multiple types of long-term memory, persistence of memory is thus dependent on ongoing activity of a protein kinase long after that memory is considered to have consolidated into a long-term stable form.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shema, Reut -- Sacktor, Todd Charlton -- Dudai, Yadin -- MH57068/MH/NIMH NIH HHS/ -- R01 MH53576/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2007 Aug 17;317(5840):951-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17702943" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Conditioning (Psychology) ; Enzyme Inhibitors/administration & dosage/*pharmacology ; Hippocampus/drug effects/enzymology/physiology ; Male ; Memory/*drug effects/*physiology ; Neocortex/drug effects/enzymology/*physiology ; Oligopeptides/administration & dosage/*pharmacology ; Protein Kinase C/*antagonists & inhibitors/*metabolism ; Rats ; Rats, Wistar ; Taste ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 100
    Publication Date: 2007-06-30
    Description: Drosophila melanogaster can make appropriate choices among alternative flight options on the basis of the relative salience of competing visual cues. We show that this choice behavior consists of early and late phases; the former requires activation of the dopaminergic system and mushroom bodies, whereas the latter is independent of these activities. Immunohistological analysis showed that mushroom bodies are densely innervated by dopaminergic axons. Thus, the circuit from the dopamine system to mushroom bodies is crucial for choice behavior in Drosophila.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhang, Ke -- Guo, Jian Zeng -- Peng, Yueqing -- Xi, Wang -- Guo, Aike -- New York, N.Y. -- Science. 2007 Jun 29;316(5833):1901-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Neuroscience, Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), 320 Yueyang Road, Shanghai 200031, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17600217" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Genetically Modified ; Axons/*physiology ; Behavior, Animal ; *Choice Behavior ; Cues ; Dopamine/*physiology ; Drosophila melanogaster/genetics/*physiology ; Female ; Immunohistochemistry ; Models, Animal ; Mushroom Bodies/*innervation/*physiology ; Mutation ; Temperature ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...