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  • Articles  (1,383)
  • Life and Medical Sciences  (1,107)
  • Female  (200)
  • Cell Line  (83)
  • Organic Chemistry
  • 1980-1984  (1,383)
  • 1950-1954
  • 1984  (657)
  • 1982  (726)
  • Medicine  (1,383)
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  • Articles  (1,383)
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  • 1980-1984  (1,383)
  • 1950-1954
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  • 1
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    Sensitivity to carcinogenesis in nude mice: skin tumors caused by transplacental exposure to ethylnitrosourea (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-11-12
    Description: Female athymic nude mice and their phenotypically normal littermates were exposed transplacentally to ethylnitrosourea. Skin tumors (papillomas and sebaceous adenomas) developed on the nude mice with an almost tenfold greater incidence than on their haired littermates. Skin tumors were also induced on nude mice but not haired controls by direct intraperitoneal treatment with ethylnitrosourea. These results indicate that nude mice have higher than normal susceptibility to carcinogenesis under some circumstances.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anderson, L M -- Last-Barney, K -- Budinger, J M -- CA 08748/CA/NCI NIH HHS/ -- CA 22498/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Nov 12;218(4573):682-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7134965" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoma/chemically induced ; Animals ; *Ethylnitrosourea ; Female ; *Maternal-Fetal Exchange ; Mice ; Mice, Nude/*physiology ; Neoplasms, Experimental/chemically induced ; *Nitrosourea Compounds ; Pregnancy ; Sebaceous Gland Neoplasms/chemically induced ; Skin Neoplasms/*chemically induced
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Prenatal and neonatal exposure to cimetidine results in gonadal and sexual dysfunction in adult males (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-29
    Description: Exposure of rats to cimetidine during intrauterine life and the immediate neonatal period results in hypoandrogenization in adult life with decreased weights of androgen-dependent tissues and decreased concentrations of testosterone. Moreover, sexual behavior patterns in adult life are disturbed as shown by a lack of sexual motivation and decreased performance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anand, S -- Van Thiel, D H -- New York, N.Y. -- Science. 1982 Oct 29;218(4571):493-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123252" target="_blank"〉PubMed〈/a〉
    Keywords: Abnormalities, Drug-Induced/*etiology ; Animals ; Animals, Suckling ; Cimetidine/metabolism/*toxicity ; Female ; Guanidines/*toxicity ; Male ; Pregnancy ; Pregnancy, Animal/drug effects ; Rats ; Sex Differentiation/*drug effects ; Sexual Behavior, Animal/drug effects
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    24-hydroxylation of 25-hydroxyvitamin D3: is it required for embryonic development in chicks? (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-30
    Description: As shown previously, laying hens given 1,25-dihydroxyvitamin D3 as their sole source of vitamin D produce fertile eggs having normal shells, but only 35 to 55 percent of the embryos are normal. Giving these hens additional 25-hydroxyvitamin D3, 24,25-dihydroxyvitamin D3, or 24,24-difluoro-25-hydroxyvitamin D3 at 1.25 nanomoles per day resulted in 90 to 100 percent normal embryos, and hence, hatchability. Since 24,24-difluoro-25-hydroxyvitamin D3 cannot be 24-hydroxylated, 24-hydroxylation is not required for this function of 25-hydroxyvitamin D3.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ameenuddin, S -- Sunde, M -- DeLuca, H F -- Ikekawa, N -- Kobayashi, Y -- New York, N.Y. -- Science. 1982 Jul 30;217(4558):451-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6979782" target="_blank"〉PubMed〈/a〉
    Keywords: 24,25-Dihydroxyvitamin D 3 ; Animal Feed ; Animals ; Calcifediol ; Calcitriol/analogs & derivatives/pharmacology ; Chick Embryo/*growth & development ; Chickens/metabolism ; Dihydroxycholecalciferols/pharmacology ; Female ; Hydroxycholecalciferols/*metabolism/pharmacology ; Hydroxylation
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-10
    Description: Rhodamine-123, a cationic laser dye, markedly reduced the clonal growth of carcinoma cells but had little effect on nontumorigenic epithelial cells in vitro. This selective inhibitory effect of Rhodamine-123 on some carcinomas is unusual since known anticancer drugs, such as arabinosyl cytosine and methotrexate, have not been shown to exhibit such selectivity in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bernal, S D -- Lampidis, T J -- Summerhayes, I C -- Chen, L B -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1117-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7146897" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carcinoma/*drug therapy ; Cell Line ; Cell Survival/drug effects ; Mice ; Mitochondria/metabolism ; Neoplasms, Experimental/drug therapy ; Rhodamine 123 ; Rhodamines/metabolism/therapeutic use ; Time Factors ; Urinary Bladder Neoplasms/drug therapy
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Measurement of intracellular free calcium in monkey kidney cells with aequorin (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-16
    Description: A method has been developed for the measurement of intracellular free calcium in mammalian cells. The calcium-sensitive photoprotein aequorin can be incorporated into isolated cells by hypo-osmotic treatment without altering the cell viability, permeability, or metabolism. Intracellular calcium activity (Cai2+) was monitored in a perfusion system. In monkey kidney cells (LLC-MK2), Cai2+ is approximately 57 nanomoles per liter. Changes in Cai2+ with time can also be followed: exposure of the cells to anaerobiosis or the calcium ionophore A23187 reversibly increases Cai2+. The method has also been successfully tested in rat hepatocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Borle, A B -- Snowdowne, K W -- New York, N.Y. -- Science. 1982 Jul 16;217(4556):252-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6806904" target="_blank"〉PubMed〈/a〉
    Keywords: *Aequorin ; Anaerobiosis ; Animals ; Calcimycin/pharmacology ; Calcium/*metabolism ; Cell Line ; Kidney/drug effects/*metabolism ; Kinetics ; *Luminescent Proteins ; Macaca mulatta
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Reversal of morphine disruption of maternal behavior by concurrent treatment with the opiate antagonist naloxone (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-08
    Description: Rats whose pregnancies were surgically terminated on day 17 of gestation were injected with morphine, morphine plus naloxone hydrochloride, or saline, and then tested for maternal responsiveness toward foster young. Morphine treatment alone significantly disrupted the rate of onset and quality of maternal responsiveness. Concurrent administration of naloxone to morphine-injected rats reinstated the rapid onset of behavioral responsiveness toward foster young, such that the responsiveness of the rats treated with both morphine and naloxone was indistinguishable from that shown by saline-injected controls. The disruptive effects of morphine did not appear to result from a general reduction in activity levels as measured in an open-field apparatus. These findings suggest that the normal onset and maintenance of maternal behavior in the rat may be regulated by endogenous opiates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bridges, R S -- Grimm, C T -- New York, N.Y. -- Science. 1982 Oct 8;218(4568):166-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123227" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*drug effects ; Drug Antagonism ; Female ; Morphine/*pharmacology ; Naloxone/*pharmacology ; Pregnancy ; Rats ; Rats, Inbred Strains
    Print ISSN: 0036-8075
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  • 7
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    Phosphoglucomutase: evidence for a new locus expressed in human milk (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-05-07
    Description: Electrophoretic study of phosphoglucomutase (PGM) in human milk revealed different patterns that can be explained by the existence of a locus distinct from the common PGM1, PGM2, and PGM3. One hundred and forty samples were tested and the results showed four different alleles of PGM4 whose frequencies were under Hardy-Weinberg equilibrium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cantu, J M -- Ibarra, B -- New York, N.Y. -- Science. 1982 May 7;216(4546):639-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6461922" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Erythrocytes/enzymology ; Female ; Gene Expression Regulation ; Humans ; Isoenzymes/genetics ; Milk, Human/*enzymology ; Phenotype ; Phosphoglucomutase/*genetics
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  • 8
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    Theory and observation in cultural transmission (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-01
    Description: Cultural phenomena may show considerable stability over time and space. Transmission mechanisms responsible for their maintenance are worthy of theoretical and empirical inquiry; they are complex and each possible pathway has different effects on evolutionary stability of traits, as can be shown theoretically. A survey designed to evaluate the importance of some components of cultural transmission on a variety of traits showed that religion and politics are mostly determined in the family, a mode of transmission which guarantees high evolutionary stability and maintenance of high variation between and within groups.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cavalli-Sforza, L L -- Feldman, M W -- Chen, K H -- Dornbusch, S M -- 10452/PHS HHS/ -- 20467/PHS HHS/ -- 20816/PHS HHS/ -- New York, N.Y. -- Science. 1982 Oct 1;218(4567):19-27.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123211" target="_blank"〉PubMed〈/a〉
    Keywords: Attitude ; Child ; Cultural Characteristics ; *Culture ; Family ; Female ; Humans ; *Interpersonal Relations ; Male ; Marriage ; Models, Psychological ; *Parent-Child Relations
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  • 9
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    Development of mouse embryos in vitro: preimplantation to the limb bud stage (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-01
    Description: Mouse embryos were grown successfully in vitro from the blastocyst stage to the limb bud stage. Mouse blastocysts grown in vitro for 10 days showed blood circulation in the yilk sac, forelimb buds, and the primordia of liver, pancreas, and lungs. These characteristics are indicative of a developmental stage equivalent to one-half of the total gestation period in utero. Improvements in culture conditions from days 7 to 9 have made it feasible to culture mouse blastocysts beyond the early somite stage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, L T -- Hsu, Y C -- AM 19535/AM/NIADDK NIH HHS/ -- AM 28550/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 1;218(4567):66-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123220" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blastocyst/*physiology ; Cell Differentiation ; Culture Media ; Culture Techniques ; Embryo, Mammalian/*physiology ; Female ; Fetal Blood ; Humans ; Mice ; Pregnancy ; Yolk Sac/physiology
    Print ISSN: 0036-8075
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  • 10
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    Calcium ionophore polarizes ooplasmic segregation in ascidian eggs (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-04-30
    Description: Calcium ionophore A23187 promotes ooplasmic segregation and orange crescent formation in eggs of the ascidian Boltenia villosa. When eggs were exposed to a gradient A23187 the orange crescent was induced to form in the region corresponding to the highest concentration of ionophore. This result is consistent with the hypothesis that a local increase in intracellular calcium polarizes cytoplasmic localization in the ascidian embryo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jeffery, W R -- 232-HDO-7098/HD/NICHD NIH HHS/ -- HD-13970/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1982 Apr 30;216(4545):545-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6803360" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-Bacterial Agents/*pharmacology ; Calcimycin/*pharmacology ; Calcium/*physiology ; Cell Compartmentation/drug effects ; Cytoplasm/ultrastructure ; Dose-Response Relationship, Drug ; Female ; Ovum/*drug effects/ultrastructure ; Urochordata
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 11
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    Naloxone antagonism of the thermoregulatory effects of phencyclidine (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-24
    Description: Phencyclidine elicits hyperthermia at low doses and hypothermia at high doses in rats. Naloxone antagonizes both effects. Phencyclidine's effects on thermo-regulation are probably mediated by an interaction with a mu opiate receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Glick, S D -- Guido, R A -- DA 02534/DA/NIDA NIH HHS/ -- DA 70082/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1982 Sep 24;217(4566):1272-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6287581" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Body Temperature Regulation/*drug effects ; Dose-Response Relationship, Drug ; Female ; Naloxone/pharmacology ; Phencyclidine/antagonists & inhibitors/*pharmacology ; Rats ; Receptors, Opioid/*drug effects
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 12
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    Serum from monkeys with histories of fetal wastage causes abnormalities in cultured rat embryos (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klein, N W -- Plenefisch, J D -- Carey, S W -- Fredrickson, W T -- Sackett, G P -- Burbacher, T M -- Parker, R M -- HD02774/HD/NICHD NIH HHS/ -- HD08633/HD/NICHD NIH HHS/ -- RR00166/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 1;215(4528):66-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7053560" target="_blank"〉PubMed〈/a〉
    Keywords: Abortion, Veterinary/*blood ; Animals ; Congenital Abnormalities/*etiology ; Ectogenesis ; Female ; Macaca nemestrina/blood ; Mice ; Pregnancy ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
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  • 13
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    Suppression of ovulation in the rat by an orally active antagonist of luteinizing hormone-releasing hormone (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-08
    Description: A synthetic antagonist of luteinizing hormone-releasing hormone blocked ovulation in rats in a dose-dependent manner when given by gavage on the afternoon of proestrus. Ovulation was delayed for at least 1 day in all animals given 2 milligrams of antogonist and in some of the animals treated with 1 or 0.5 milligram. Oral administration of 2 milligrams also blocked the preovulatory surge of luteinizing hormone. This demonstration that antagonists of luteinizing hormone-releasing hormone can have oral antiovulatory activity clearly enhances their therapeutic potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nekola, M B -- Horvath, A -- Ge, L J -- Coy, D H -- Schally, A V -- HD-0-2831/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 8;218(4568):160-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6750790" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Oral ; Animals ; Female ; Gonadotropin-Releasing Hormone/*analogs & derivatives/pharmacology ; Luteinizing Hormone/secretion ; Ovulation/*drug effects ; Pregnancy ; Proestrus/drug effects ; Rats ; Rats, Inbred Strains
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    Pregnancy suppression by active immunization against gestation-specific riboflavin carrier protein (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-04-09
    Description: A riboflavin carrier protein isolated from chickens cross-reacts with a gestation-specific rodent carrier for riboflavin. Active immunization of female rats of proved fertility with the purified chicken carrier protein completely yet reversibly suppressed early pregnancy without impairing implantation per se. Concurrently there were no discernible adverse effects on maternal health in terms of weight gain, vitamin status, and fertility.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murty, C V -- Adiga, P R -- New York, N.Y. -- Science. 1982 Apr 9;216(4542):191-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063879" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies ; Carrier Proteins/*immunology ; Female ; Fetal Resorption/immunology ; Flavins/blood ; Glutathione Reductase/blood ; Immunization ; *Membrane Transport Proteins ; Pregnancy ; *Pregnancy, Animal ; Progesterone/blood ; Rats
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  • 15
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    Maternal ethanol exposure induces transient impairment of umbilical circulation and fetal hypoxia in monkeys (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-11-12
    Description: When ethanol was administered intravenously to pregnant monkeys, a transient but marked collapse of umbilical vasculature was observed uniformly within about 15 minutes. The ethanol-induced impairment of umbilical circulation produced severe hypoxia and acidosis in the fetus; recovery occurred during the succeeding hour. This striking interruption of feto-placental circulation may explain one of the mechanisms of mental retardation, a frequent manifestation in children afflicted with fetal alcohol syndrome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mukherjee, A B -- Hodgen, G D -- New York, N.Y. -- Science. 1982 Nov 12;218(4573):700-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6890235" target="_blank"〉PubMed〈/a〉
    Keywords: Acetaldehyde/blood ; Animals ; Disease Models, Animal ; Ethanol/blood/*pharmacology ; Female ; Fetal Alcohol Spectrum Disorders/*etiology ; Fetal Distress/*chemically induced ; Macaca fascicularis ; Macaca mulatta ; Pregnancy ; Pregnancy, Animal/*drug effects ; Umbilical Cord/*drug effects
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  • 16
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    Lung fibrosis and emphysema: divergent responses to a common injury? (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-23
    Description: Cadmium chloride, administered intratracheally to golden Syrian hamsters, causes an acute lung injury which evolves into a lesion with functional and morphological features of diffuse fibrosis. With simultaneous feeding of a lathyrogen, beta-aminoproprionitrile, this same injury evolves into functional and morphological changes of bullous emphysema. These results suggest that the same lung injury might result in either fibrosis or emphysema, connective tissue synthesis during the healing phase being the critical determinant.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Niewoehner, D E -- Hoidal, J R -- New York, N.Y. -- Science. 1982 Jul 23;217(4557):359-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089570" target="_blank"〉PubMed〈/a〉
    Keywords: Aminopropionitrile/pharmacology ; Animals ; Cadmium/pharmacology ; Cadmium Chloride ; Collagen/biosynthesis ; Connective Tissue/metabolism ; Cricetinae ; Elastin/biosynthesis ; Female ; Intubation, Intratracheal ; Lung/pathology ; Mesocricetus ; Pulmonary Emphysema/*chemically induced/pathology ; Pulmonary Fibrosis/*chemically induced/pathology
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  • 17
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    Hemispheric asymmetries in the behavioral and hormonal effects of sexually differentiating mammalian brain (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-22
    Description: Estrogen pellets were placed in either the right or left hypothalamus of newborn female rats so that only one side of this brain area was exposed to the postnatal masculinizing and defeminizing effects of the hormone. The effects of estrogen on gonadotropin secretion and reproductive behavior depended on both the region and the side of implantation. Exposure of the left hypothalamus to estrogen resulted in defeminized development. Exposure of the right hypothalamus to estrogen resulted in masculinized development. Thus the response of the developing hypothalamus to gonadal steroids may be asymmetric.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nordeen, E J -- Yahr, P -- New York, N.Y. -- Science. 1982 Oct 22;218(4570):391-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123240" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Estradiol/*pharmacology ; Female ; *Functional Laterality ; Hypothalamus/*physiology ; Male ; Ovary/growth & development ; Rats ; *Sex Differentiation/drug effects ; Sexual Behavior, Animal/physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 18
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    Norethisterone, a major ingredient of contraceptive pills, is a suicide inhibitor of estrogen biosynthesis (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-03-05
    Description: Norethisterone (17 alpha-ethynyl-19-nortestosterone) is an effective irreversible inhibitor of estrogen synthetase (aromatase), the enzyme responsible for the conversion of androgens to estrogens, even at a 2 X 10(-6) molar concentration. This irreversible inactivation, which is directed toward the active site of aromatase and requires the cofactor-reduced nicotinamide adenine dinucleotide phosphate, is both time- and concentration-dependent. Ethisterone (17 alpha-ethynyltestosterone), in contrast, is not a suicide inhibitor of aromatase even at concentrations of 10(-4) molar.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Osawa, Y -- Yarborough, C -- HDO4945/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1982 Mar 5;215(4537):1249-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7058343" target="_blank"〉PubMed〈/a〉
    Keywords: *Aromatase Inhibitors ; Binding Sites/drug effects ; Contraceptives, Oral/*pharmacology ; Estrogens/*biosynthesis ; Female ; Humans ; Kinetics ; Microsomes/enzymology ; Norethindrone/*pharmacology ; Oxidoreductases/*antagonists & inhibitors ; Placenta/enzymology ; Pregnancy
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 19
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    Evidence for the clonal origin of spontaneous metastases (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-23
    Description: A cultured cell line of the K-1735 melanoma was x-irradiated to induce chromosome breakage and rearrangements and then was implanted into the footpads of syngenic C3H mice. Spontaneous lung metastases were isolated from different animals, established in culture as individual lines, and then karyotyped. Within certain metastases, the same chromosomal abnormality (or abnormalities) (recombinant chromosomes) was found in all the cells examined. Most metastases differed from one another in that they exhibited characteristic combinations of chromosomal markers. These findings indicated that the metastases were clonal and that they probably originated from different progenitor cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Talmadge, J E -- Wolman, S R -- Fidler, I J -- N01-CO-75380/CO/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 23;217(4557):361-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6953592" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Chromosome Aberrations ; Genetic Markers ; Karyotyping ; Lung Neoplasms/secondary ; Melanoma ; Mice ; Mice, Inbred C3H ; Neoplasm Metastasis/*pathology ; Neoplasms, Experimental/pathology
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  • 20
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    Oxytocin induces maternal behavior in virgin female rats (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-05-07
    Description: Intracerebroventricular administration of oxytocin to virgin female rats that had been ovariectomized and primed with estrogen 48 hours previously induced a rapid onset of full maternal behavior. The maternal behavior persisted and its incidence was dose-related. Tocinoic acid, the ring structure of oxytocin, also rapidly induced the onset of persistent, full maternal behavior. Arginine vasopressin induced persistent maternal behavior, but this behavior had a later onset. Prostaglandin F2 alpha induced strong partial maternal behavior, which showed early onset but did not persist. Many other peptides, ovarian steroids, and prostaglandin E2 were no more effective than saline. These findings suggest that the release of oxytocin and prostaglandin F2 alpha during labor may promote maternal behavior in rats.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pedersen, C A -- Ascher, J A -- Monroe, Y L -- Prange, A J Jr -- MH-22536/MH/NIMH NIH HHS/ -- MH-32316/MH/NIMH NIH HHS/ -- MH-34933/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1982 May 7;216(4546):648-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7071605" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arginine Vasopressin/pharmacology ; Brain/physiology ; Female ; Injections, Intraventricular ; *Maternal Behavior ; Oxytocin/administration & dosage/*pharmacology ; Rats ; Structure-Activity Relationship
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  • 21
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    Transplantation of leukemic bone marrow treated with cytotoxic antileukemic antibodies and complement (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-16
    Description: The ability of antiserum against murine L1210 leukemia to remove residual leukemia cells from murine bone marrow was investigated. Leukemic marrow was treated in vitro with antiserum and complement and used to hematologically reconstitute mice that had been irradiated with doses lethal to bone marrow. Following infusion of treated leukemic marrow, normal marrow returned without evidence of leukemia. More than 90 percent of the animals have survived for 11 months without untoward effects, suggesting that the technique may be of use in the treatment of acute leukemia in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Trigg, M E -- Poplack, D G -- New York, N.Y. -- Science. 1982 Jul 16;217(4556):259-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7046048" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibodies ; *Bone Marrow Transplantation ; Cell Survival ; *Complement System Proteins ; Cytotoxicity, Immunologic ; Female ; Leukemia L1210/*immunology/therapy ; Male ; Mice ; Mice, Inbred DBA
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  • 22
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    Breast-feeding patterns in low-income countries (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-10
    Description: Breast-feeding is important to infant nutrition, morbidity, and mortality, and to postpartum amenorrhea (hence to birth intervals). Evidence on breast-feeding patterns in low-income countries from nationally representative World Fertility Surveys and secondary sources shows that in all but a few such countries most children are breast-fed for at least a few months. The limited evidence available on trends seems to indicate a decline in the duration of breast-feeding, but in most of Asia and Africa breast-feeding is almost universal during at least the first 6 months. Earlier weaning is common in Latin America.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Popkin, B M -- Bilsborrow, R E -- Akin, J S -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1088-93.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7146896" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; Asia ; *Breast Feeding ; *Developing Countries ; Female ; Humans ; Rural Population ; South America ; Time Factors ; Urban Population
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 23
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    Influence of female hormonal state on rhesus sexual behavior varies with space for social interaction (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-23
    Description: The sexual behavior of rhesus monkeys in 15 male-female pairings was observed in both a large and a small area during the follicular and luteal phases of the female's cycle. Males ejaculated in all tests at the follicular phase of the female's cycle and in 53 percent of tests at the luteal phase. However, a significant decline in ejaculation during tests at the luteal phase occurred in the large, but not in the small area. Thus the degree to which the pair's sexual behavior was influenced by the female's hormonal state depended on the spatial conditions of the test.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wallen, K -- MH35835/MH/NIMH NIH HHS/ -- RR-00165/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 23;217(4557):375-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7201164" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Copulation ; Ejaculation ; *Estrus ; Female ; Macaca/*physiology ; Macaca mulatta/*physiology ; Male ; Pregnancy ; Proestrus ; Sexual Behavior, Animal/*physiology ; Social Behavior ; *Spatial Behavior
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  • 24
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    Asian bull elephants: Flehmen-like responses to extractable components in female elephant estrous urine (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-09
    Description: Flehmen-like responses (urine tests) are one of the characteristic behavioral reactions of male Asian elephants (Elephants maximus) to cow elephants in estrus. Components of the urine of estrous cow elephants were extracted with organic solvents and partially purified by chromatography and shown to evoke Flehmen-like responses when they were presented to adult bulls.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rasmussen, L E -- Schmidt, M J -- Henneous, R -- Groves, D -- Daves, G D Jr -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):159-62.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089549" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Elephants/anatomy & histology/*physiology ; Estrus Detection ; Female ; Male ; Pheromones/*urine ; Sex Attractants/isolation & purification/*urine ; *Sexual Behavior, Animal
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  • 25
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    Human fetal movement: spontaneous oscillations near one cycle per minute (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-24
    Description: Spectral analysis of spontaneous fluctuations in human fetal movement revealed strong oscillations at frequencies between 0.24 and 0.90 cycle per minute, which are much higher than those of the cyclic alternation of quiet and active states in the fetus and neonate. Oscillations at frequencies up to 2.88 cycles per minute were also detected, but they were usually much weaker. The prominent peaks in the fetal movement spectra are in the frequency range of recently reported neonatal motor rhythms, and indicate the existence of a cyclic process controlling spontaneous motor output that oscillates near one cycle per minute and begins to function in utero.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robertson, S S -- Dierker, L J -- Sorokin, Y -- Rosen, M G -- M01RR00210/RR/NCRR NIH HHS/ -- P50HD11089/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1982 Dec 24;218(4579):1327-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7146916" target="_blank"〉PubMed〈/a〉
    Keywords: Female ; Fetus/*physiology ; Humans ; *Movement ; Pregnancy ; Pregnancy Trimester, Third ; Spectrum Analysis/methods ; Time Factors
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  • 26
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    Subperiosteal expansion and cortical remodeling of the human femur and tibia with aging (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-03
    Description: Increases with aging in subperiosteal dimensions and second moments of area (measures of bending and torsional rigidity) in femoral and tibial cross sections are documented in an archeological sample from the American Southwest. Significant differences between cross-sectional sites and between sexes in the pattern of cortical remodeling with age are also present. These differences appear to be related to variations in the stress or strain levels in different regions of the femur and tibia which result from in vivo mechanical loadings of the lower limb.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ruff, C B -- Hayes, W C -- AM00749/AM/NIADDK NIH HHS/ -- AM26740/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Sep 3;217(4563):945-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7112107" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Aging ; Bone Development ; Female ; Femur/*physiology ; Fractures, Bone/etiology ; Growth ; Humans ; Male ; Middle Aged ; Periosteum/*physiology ; Physical Exertion ; Sex Characteristics ; Stress, Mechanical ; Tibia/*physiology
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  • 27
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    Congenital malformations induced by laetrile (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-03-19
    Description: Laetrile administered orally ot pregnant hamsters caused skeletal malformations in the offspring, but intravenous laetrile filed to result in embryopathic effects. Oral laetrile significantly increased in situ cyanide concentrations, while intravenous laetrile did not. Thiosulfate administration protected embryos from the teratogenic effects of oral laetrile. The embryopathic effects of oral laetrile appear to be due to cyanide released by bacterial beta-glucosidase activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Willhite, C C -- New York, N.Y. -- Science. 1982 Mar 19;215(4539):1513-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063858" target="_blank"〉PubMed〈/a〉
    Keywords: Abnormalities, Drug-Induced/*etiology ; Administration, Oral ; Amygdalin/administration & dosage/metabolism/*toxicity ; Animals ; Cricetinae ; Female ; Injections, Intravenous ; Pregnancy
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  • 28
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    Recovery of olfactory function after bilateral bulbectomy (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-04-16
    Description: Mice were trained to discriminate between scented and unscented air. After olfactory bulbs were removed, discrimination was lost, but returned with the formation of synaptic connections between regenerated primary olfactory neurons and the cortex of the forebrain. The acquisition of a second olfactory-mediated task by long-term bulbectomized mice and controls was indistinguishable. The results emphasize the plasticity of the nervous system, correlate the presence of neural connections between olfactory mucosa and forebrain with the recovery of olfactory function, suggest that olfactory-mediated memory resides at least in part outside the olfactory bulbs, and demonstrate that the bulbs are not required for the acquisition of olfactory tasks.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wright, J W -- Harding, J W -- NS 13976/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Apr 16;216(4543):322-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063891" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carnosine/physiology ; Central Nervous System/*physiology ; Female ; Memory/physiology ; Mice ; Neuronal Plasticity ; Olfactory Bulb/*physiology ; Olfactory Pathways/*physiology ; Smell/*physiology
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  • 29
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    Transformation of human leukocytes by cocultivation with an adult T cell leukemia virus producer cell line (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-20
    Description: The transmission of adult T cell leukemia virus, a human retrovirus, into fresh leukocytes from normal humans was examined. One of three virus-carrying cell lines, tested after being subjected to lethal x-irradiation, consistently transformed leukocytes from adult peripheral blood and umbilical cord blood. All the transformed cell lines expressed adult T cell leukemia virus-associated antigen, but transformed lines originating from adult and umbilical cord blood exhibited T cell and non-T, non-B cell surface natures, respectively. Efforts to transform human leukocytes with cell-free virus were unsuccessful.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yamamoto, N -- Okada, M -- Koyanagi, Y -- Kannagi, M -- Hinuma, Y -- New York, N.Y. -- Science. 1982 Aug 20;217(4561):737-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6980467" target="_blank"〉PubMed〈/a〉
    Keywords: Antigens, Surface/immunology ; Antigens, Viral/immunology ; B-Lymphocytes/immunology ; Cell Line ; Fetal Blood ; Genes, Viral ; Humans ; Karyotyping ; Leukocytes/*physiology ; Retroviridae/*genetics ; T-Lymphocytes/immunology ; *Transformation, Genetic
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  • 30
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    Wound tissue can utilize a polymeric template to synthesize a functional extension of skin (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-01-08
    Description: Prompt and long-term closure of full-thickness skin wounds is guinea pigs and humans is achieved by applying a bilayer polymeric membrane. The membrane comprises a top layer of a silicone elastomer and a bottom layer of a porous cross-linked network of collagen and glycosaminoglycan. The bottom layer can be seeded with a small number of autologous basal cells before grafting. No immunosuppression is used and infection, exudation, and rejection are absent. Host tissue utilizes the sterile membrane as a culture medium to synthesize neoepidermal and neodermal tissue. A functional extension of skin over the entire wound area is formed in about 4 weeks.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yannas, I V -- Burke, J F -- Orgill, D P -- Skrabut, E M -- GM 21700/GM/NIGMS NIH HHS/ -- GM 23946/GM/NIGMS NIH HHS/ -- HL 14322/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 8;215(4529):174-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7031899" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Animals ; Burns/*therapy ; Cells, Cultured ; Child ; Child, Preschool ; Collagen/therapeutic use ; Female ; Glycosaminoglycans/therapeutic use ; Guinea Pigs ; Humans ; Male ; Middle Aged ; Silicone Elastomers/therapeutic use ; *Skin Transplantation ; *Wound Healing
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  • 31
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    Bacterial contamination of human tumor samples (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-08-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1984 Aug 17;225(4663):670-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6087452" target="_blank"〉PubMed〈/a〉
    Keywords: Carcinoma, Hepatocellular/genetics ; Cell Line ; DNA, Bacterial ; *DNA, Neoplasm ; DNA, Viral ; Hepatitis B virus/genetics ; Humans ; Liver Neoplasms/genetics ; Oncogenes
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  • 32
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    Cancer and diet (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-05-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1984 May 18;224(4650):658,660,662 passim.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6719107" target="_blank"〉PubMed〈/a〉
    Keywords: Carcinogens/pharmacology ; Diet/*adverse effects ; Female ; Humans ; Male ; Neoplasms/*etiology
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  • 33
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    Biotechnology as an intellectual property (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-04-27
    Description: Recent advances in biotechnology have created many public policy and legal issues, one of the most significant of which is the treatment of biotechnological industrial products, particularly under the patent system. Patents represent one of several types of intellectual property; their ownership confers the right to exclude others from benefitting from the tangible products of a proprietary subject matter. Intellectual property law and its protections will play a major role in the rate at which biotechnology develops in the United States. In this article biotechnological intellectual property issues are reviewed in the context of their underlying legal requirements. The implications of other factors, such as international competition, research funding, and gene ownership, are also considered.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Adler, R G -- New York, N.Y. -- Science. 1984 Apr 27;224(4647):357-63.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6584975" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; Cell Line ; Copyright ; DNA, Recombinant ; Economic Competition ; Federal Government ; *Genetic Engineering ; *Genetics, Microbial ; Government Regulation ; Legislation as Topic ; Ownership ; *Patents as Topic ; Research ; *Technology ; United States ; as a question of intellectual property rights. Attention is focused on the major ; role played by the U.S. patent system in establishing such rights, as illustrated ; by the case of products of recombinant DNA research. Trade secret, copyright, and ; trademark protections are also considered, as are policy issues such as ; international competition in the development of biomedical technologies and ; financing arrangements.
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  • 34
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    Heterochronic mutants of the nematode Caenorhabditis elegans (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-26
    Description: Mutations in the Caenorhabditis elegans genes lin-14, lin-28, and lin-29 cause heterochronic developmental defects: the timing of specific developmental events in several tissues is altered relative to the timing of events in other tissues. These defects result from temporal transformations in the fates of specific cells, that is, certain cells express fates normally expressed by cells generated at other developmental stages. The identification and characterization of genes that can be mutated to cause heterochrony support the proposal that heterochrony is a mechanism for phylogenetic change and suggest cellular and genetic bases for heterochronic variation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ambros, V -- Horvitz, H R -- GM24663/GM/NIGMS NIH HHS/ -- GM24943/GM/NIGMS NIH HHS/ -- HD00369/HD/NICHD NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 Oct 26;226(4673):409-16.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494891" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Caenorhabditis/*genetics ; Female ; *Genes ; Genetic Variation ; Male ; *Mutation ; *Phylogeny ; Time Factors
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    Rapid expulsion of Trichinella spiralis in suckling rats (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-05
    Description: Orally administered Trichinella spiralis muscle larvae were rapidly expelled by rat pups suckling an immune dam. The immunity was delivered in the milk; substantial resistance was conferred on normal rat pups suckled for only 24 hours by a Trichinella-immune foster mother. The pups were protected by oral or systemic administration of specific serum antibodies. When infused into a normal lactating dam, these antibodies accumulated in the serum of her suckling pups.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Appleton, J A -- McGregor, D D -- AI 14490/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1984 Oct 5;226(4670):70-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6474191" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Suckling ; Antibodies/immunology ; Colostrum/immunology ; Female ; *Immunity, Maternally-Acquired ; Immunization, Passive ; Intestinal Diseases, Parasitic/*immunology/parasitology ; Intestinal Mucosa/parasitology ; Milk/*immunology ; Rats ; Trichinella/*immunology/physiology ; Trichinellosis/*immunology/parasitology
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    Inhibition of aldosterone production by an atrial extract (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-01
    Description: Crude extracts of rat atria reduced the basal amount of aldosterone released from rat zona glomerulosa cells and partially inhibited aldosterone stimulation by adrenocorticotropic hormone and angiotensin II. The destruction of this activity by trypsin suggests that the active factor is a peptide, possibly atrial natriuretic factor. These data suggest that atrial natriuretic factor affects sodium excretion by the kidneys both directly and through the inhibition of aldosterone production.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Atarashi, K -- Mulrow, P J -- Franco-Saenz, R -- Snajdar, R -- Rapp, J -- New York, N.Y. -- Science. 1984 Jun 1;224(4652):992-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6326267" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/pharmacology ; Aldosterone/*biosynthesis ; Angiotensin II/pharmacology ; Animals ; *Atrial Function ; Dogs ; Female ; Kidney/drug effects/metabolism ; Mineralocorticoid Receptor Antagonists/pharmacology ; Natriuresis/drug effects ; Rats ; Rats, Inbred Strains ; Trypsin/pharmacology
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    Stress hormones: their interaction and regulation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-04
    Description: Stress stimulates several adaptive hormonal responses. Prominent among these responses are the secretion of catecholamines from the adrenal medulla, corticosteroids from the adrenal cortex, and adrenocorticotropin from the anterior pituitary. A number of complex interactions are involved in the regulation of these hormones. Glucocorticoids regulate catecholamine biosynthesis in the adrenal medulla and catecholamines stimulate adrenocorticotropin release from the anterior pituitary. In addition, other hormones, including corticotropin-releasing factor, vasoactive intestinal peptide, and arginine vasopressin stimulate while the corticosteroids and somatostatin inhibit adrenocorticotropin secretion. Together these agents appear to determine the complex physiologic responses to a variety of stressors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Axelrod, J -- Reisine, T D -- New York, N.Y. -- Science. 1984 May 4;224(4648):452-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6143403" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/metabolism ; Adrenal Cortex/metabolism ; Adrenal Medulla/metabolism ; Adrenocorticotropic Hormone/*metabolism ; Animals ; Brain/metabolism ; Catecholamines/*metabolism ; Cell Line ; Corticotropin-Releasing Hormone/metabolism ; Cyclic AMP/metabolism ; Glucocorticoids/*metabolism ; Humans ; Phospholipases A/metabolism ; Pituitary Gland, Anterior/metabolism ; Receptors, Adrenergic, alpha/metabolism ; Receptors, Adrenergic, beta/metabolism ; Receptors, Cell Surface/metabolism ; Receptors, Corticotropin-Releasing Hormone ; Receptors, Somatostatin ; Somatostatin/pharmacology ; Stress, Physiological/*metabolism ; Stress, Psychological/metabolism ; Sympathetic Nervous System/metabolism ; Vasoactive Intestinal Peptide/pharmacology ; Vasopressins/pharmacology
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    Regulation of a hybrid gene by glucose and temperature in hamster fibroblasts (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-12
    Description: A novel eukaryotic hybrid gene has been constructed from the 5' sequence of a rat gene and the bacterial neomycin-resistance gene. After transfection into hamster fibroblasts, the neo transcripts can be induced to high levels by the absence of glucose. Furthermore, this hybrid gene can be regulated by temperature when it is introduced into a temperature-sensitive mutant cell line.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Attenello, J W -- Lee, A S -- CA-27607/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Oct 12;226(4671):187-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6484570" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cricetinae ; DNA, Recombinant ; Drug Resistance, Microbial ; Fibroblasts ; *Gene Expression Regulation ; Genes, Bacterial ; *Genes, Regulator ; Glucose/*pharmacology ; *HSP70 Heat-Shock Proteins ; Membrane Proteins/biosynthesis/*genetics ; Mutation ; Neomycin/pharmacology ; Rats ; Temperature ; Transcription, Genetic ; Transfection
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    T-cell growth factor gene: lack of expression in human T-cell leukemia-lymphoma virus-infected cells (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-09
    Description: Activated mature T cells require T-cell growth factor (TCGF) for continuous proliferation. However, many mature T cells infected with human T-cell leukemia-lymphoma virus grow independently of exogenously added TCGF. It is now reported that cells infected with this virus also lack detectable TCGF messenger RNA (less than one copy per cell) and thus do not produce their own growth factor. The results apparently rule out an autostimulation mechanism of growth control.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arya, S K -- Wong-Staal, F -- Gallo, R C -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1086-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6320374" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Deltaretrovirus/*physiology ; *Gene Expression Regulation/drug effects ; Humans ; Interferon-gamma/genetics ; Interleukin-2/*genetics ; Phytohemagglutinins/pharmacology ; RNA, Messenger/*genetics ; T-Lymphocytes/metabolism/*microbiology ; Tetradecanoylphorbol Acetate/pharmacology
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    Identification of DNA sequence responsible for 5-bromodeoxyuridine-induced gene amplification (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-31
    Description: Bromodeoxyuridine (BrdUrd) treatment of the prolactin nonproducing subclone of GH cells (rat pituitary tumor cells) induces amplification of a 20-kilobase DNA fragment including all of the prolactin gene coding sequences. This amplified DNA segment, which is flanked by two unamplified regions, thus designates a unit of BrdUrd-induced amplified sequence. Cloned DNA segments, 10.3 kilobases long, from the 5' end of the rat prolactin gene of BrdUrd-responsive and -nonresponsive cells, were ligated to the thymidine kinase gene of herpes simplex virus type 1 (HSV1TK), and the hybrid DNA was transferred to thymidine kinase-deficient mouse fibroblast cells by transfection. The HSV1TK gene and the rat prolactin gene were amplified together in drug-treated transfectants carrying the hybrid DNA HSV1TK gene and rat prolactin gene of BrdUrd-responsive GH cells. These results suggest that the 10.3-kilobase DNA segment at the 5' end of the rat prolactin gene of BrdUrd-responsive GH cells carries the information for drug-induced gene amplification (amplicon) and that another gene, such as the HSV1TK gene, is also amplified when the latter is placed adjacent to this segment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Biswas, D K -- Hartigan, J A -- Pichler, M H -- CA28218/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):941-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6089335" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Bromodeoxyuridine/*pharmacology ; Cell Line ; Cloning, Molecular ; DNA/*genetics ; DNA, Recombinant ; *Gene Amplification ; Genes, Viral ; Mice ; Prolactin/genetics ; Rats ; Simplexvirus/genetics ; Thymidine Kinase/genetics ; Transfection
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    Nuclear magnetic resonance technology for medical studies (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-19
    Description: Nuclear magnetic resonance proton imaging provides anatomical definition of normal and abnormal tissues with a contrast and detection sensitivity superior to those of x-ray computed tomography in the human head and pelvis and parts of the cardiovascular and musculoskeletal systems. Recent improvements in technology should lead to advances in diagnostic imaging of the breast and regions of the abdomen. Selected-region nuclear magnetic resonance spectroscopy of protons, carbon-13, and phosphorus-31 has developed into a basic science tool for in vivo studies on man and a unique tool for clinical diagnoses of metabolic disorders. At present, nuclear magnetic resonance is considered safe if access to the magnet environment is controlled. Technological advances employing field strengths over 2 teslas will require biophysical studies of heating and static field effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Budinger, T F -- Lauterbur, P C -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):288-98.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6385252" target="_blank"〉PubMed〈/a〉
    Keywords: Blood Circulation ; Bone Diseases/diagnosis ; Breast Diseases/diagnosis ; Central Nervous System Diseases/diagnosis ; Digestive System Diseases/diagnosis ; Female ; Genital Diseases, Female/diagnosis ; Heart Diseases/diagnosis ; Humans ; Ions ; Liver Diseases/diagnosis ; Lung Diseases/diagnosis ; *Magnetic Resonance Spectroscopy/instrumentation/methods ; Magnetics ; Muscular Diseases/diagnosis ; Splenic Diseases/diagnosis ; Urologic Diseases/diagnosis
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    Altered transcription of the c-abl oncogene in K-562 and other chronic myelogenous leukemia cells (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-07-06
    Description: Expression of the cellular abl (c- abl ) oncogene was studied in K-562 and other chronic myelogenous leukemia (CML) cells and cell lines by means of Northern blot hybridization. In contrast to non-CML cells, which contained 7.4- and 6.8-kilobase abl -related transcripts, the CML cells contained a predominant and novel 8.2-kilobase abl -related RNA. In addition, the levels of abl -related message were up to eight times higher in CML cell lines from patients at the blast crisis stage of the disease compared with CML cells obtained during the chronic phase and with non-CML cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Collins, S J -- Kubonishi, I -- Miyoshi, I -- Groudine, M T -- New York, N.Y. -- Science. 1984 Jul 6;225(4657):72-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6587568" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Chromosomes, Human, 21-22 and Y ; Chromosomes, Human, 6-12 and X ; DNA, Neoplasm/genetics ; Humans ; Leukemia, Myeloid/*genetics ; Mice ; Nucleic Acid Hybridization ; *Oncogenes ; RNA, Messenger/genetics ; *Transcription, Genetic
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    Cell biology of synaptic plasticity (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-09-21
    Description: The nervous system of mammals retains throughout the animals' life-span the ability to modify the number, nature, and level of activity of its synapses. Synaptic plasticity is most evident after injury to the nervous system, and the cellular and molecular mechanisms that make it possible are beginning to be understood. Transplantation of brain tissue provides a powerful approach for studying mechanisms of synaptic plasticity. In turn, understanding the response of the central nervous system to injury can be used to optimize transplant survival and integration with the host brain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cotman, C W -- Nieto-Sampedro, M -- AG 00538/AG/NIA NIH HHS/ -- MH 19691/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1984 Sep 21;225(4668):1287-94.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6382610" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Brain/*growth & development/*physiology ; Cerebral Cortex/physiology/transplantation ; Denervation ; Female ; Humans ; Nerve Regeneration ; *Neuronal Plasticity ; Peripheral Nerves/physiology ; Pregnancy ; Synapses/*physiology
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    Reinitiation of growth in senescent mouse mammary epithelium in response to cholera toxin (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-15
    Description: Several lines of mouse mammary tissue that had been serially transplanted until mitotic senescence was reached were exposed in vivo to plastic implants that slowly released cholera toxin. Gland tissue surrounding the implants displayed new end buds, indicating reinitiation of growth and morphogenesis. The ability of cholera toxin, which elevates intracellular adenosine 3',5'-monophosphate, to temporarily reverse the senescent phenotype suggests that this mitotic dysfunction results not from generalized cellular deterioration but from specific changes in cell regulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Daniel, C W -- Silberstein, G B -- Strickland, P -- 1050/PHS HHS/ -- New York, N.Y. -- Science. 1984 Jun 15;224(4654):1245-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6328652" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division/*drug effects ; Cell Line ; Cholera Toxin/*pharmacology ; Cyclic AMP/physiology ; DNA/biosynthesis ; Epithelium/drug effects ; Female ; Fibroblasts/drug effects ; Humans ; Mammary Glands, Animal/*drug effects ; Mice ; Mice, Inbred BALB C ; Mitosis/drug effects
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    A new type D retrovirus isolated from macaques with an immunodeficiency syndrome (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-02-10
    Description: Macaque monkeys with the recently described acquired immunodeficiency syndrome show a marked defect in T-lymphocyte function and die with opportunistic infections and lymphoproliferative abnormalities. In the study described here a new type D retrovirus was isolated from two Macaca cyclopis with this syndrome. This virus is related to, but distinct from, Mason-Pfizer monkey virus, a type D retrovirus previously isolated from a mammary tumor of a rhesus monkey (Macaca mulatta).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Daniel, M D -- King, N W -- Letvin, N L -- Hunt, R D -- Sehgal, P K -- Desrosiers, R C -- R01-A1 20729/PHS HHS/ -- RR00168/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1984 Feb 10;223(4636):602-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695172" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Burkitt Lymphoma ; Cell Line ; Humans ; Immunologic Deficiency Syndromes/*microbiology ; Macaca ; Nucleic Acid Hybridization ; Retroviridae/genetics/immunology/*isolation & purification
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    Test-tube embryology in the dock (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dickson, D -- New York, N.Y. -- Science. 1984 Aug 10;225(4662):606.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6740327" target="_blank"〉PubMed〈/a〉
    Keywords: *Embryo Research ; Embryo Transfer ; Embryo, Mammalian ; Female ; Fertilization in Vitro ; *Government Regulation ; Great Britain ; Humans ; *Legislation, Medical ; Oocyte Donation ; Pregnancy ; special license be required for all embryo experimentation and that any ; unlicensed research be considered a criminal offense. Regulation would be by a ; new statutory body responsible for monitoring in vitro fertilization research and ; various types of fertility treatments. Surrogate motherhood would be prohibited. ; Reservations expressed by professional groups as well as by some committee ; members about the restrictions reflect legal and social problems surrounding the ; uses of human embryos.
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    Nucleotide sequence of a human Blym transforming gene activated in a Burkitt's lymphoma (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-03
    Description: The nucleotide sequence of a human Blym-1 transforming gene activated in a Burkitt's lymphoma cell line was determined. This sequence predicts a small protein of 58 amino acids that is 33 percent identical to the predicted product of chicken Blym-1, the activated transforming gene of chicken B cell lymphomas. Both the human and chicken Blym-1 genes exhibit significant identity to an amino-terminal region of transferrins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diamond, A -- Devine, J M -- Cooper, G M -- CA 07250/CA/NCI NIH HHS/ -- CA 28946/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 3;225(4661):516-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6330897" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Base Sequence ; Burkitt Lymphoma/*genetics ; Cell Line ; *Cell Transformation, Neoplastic ; DNA Restriction Enzymes ; Humans ; *Oncogenes ; Structure-Activity Relationship ; Transcription, Genetic ; Transferrin/genetics
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    Smell identification ability: changes with age (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-12-21
    Description: Smell identification ability was measured in 1955 persons ranging in age from 5 to 99 years. On the average, women outperformed men at all ages, and nonsmokers outperformed smokers. Peak performance occurred in the third through fifth decades and declined markedly after the seventh. More than half of those 65 to 80 years old evidenced major olfactory impairment. After 80 years, more than three-quarters evidenced major impairment. Given these findings, it is not surprising that many elderly persons complain that food lacks flavor and that the elderly account for a disproportionate number of accidental gas poisoning cases each year.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Doty, R L -- Shaman, P -- Applebaum, S L -- Giberson, R -- Siksorski, L -- Rosenberg, L -- NS 16265/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1984 Dec 21;226(4681):1441-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6505700" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; *Aging ; Child ; Child, Preschool ; Female ; Humans ; Male ; Middle Aged ; Sensory Thresholds ; Sex Factors ; Smell/*physiology ; Smoking
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    Scintigraphy of normal mouse ovaries with monoclonal antibodies to ZP-2, the major zona pellucida protein (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-31
    Description: The zona pellucida is an extracellular glycocalyx, made of three sulfated glycoproteins, that surrounds mammalian oocytes. Parenterally administered monoclonal antibodies specific for ZP-2, the most abundant zona protein, localize in the zona pellucida. When labeled with iodine-125, these monoclonal antibodies demonstrate a remarkably high target-to-nontarget tissue ratio and provide clear external radioimaging of ovarian tissue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉East, I J -- Keenan, A M -- Larson, S M -- Dean, J -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):938-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6474160" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal/*analysis ; Digestive System/immunology ; *Egg Proteins ; Female ; Glycoproteins/analysis/*immunology ; Iodine Radioisotopes ; Liver/immunology ; Male ; *Membrane Glycoproteins ; Mice ; Myocardium/immunology ; Ovary/analysis/immunology/*radionuclide imaging ; Ovum/*analysis ; *Receptors, Cell Surface ; Tissue Distribution ; Zona Pellucida/*analysis/immunology
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    Coronary arteries of cardiac patients are hyperreactive and contain stores of amines: a mechanism for coronary spasm (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-03-30
    Description: Coronary arteries from hearts of cardiac patients contain significantly higher concentrations of histamine than do those from noncardiac patients. The coronary vessels of cardiac patients are also hyperresponsive to histamine and serotonin. These differences between groups of patients suggest an explanation for coronary artery spasm in heart disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kalsner, S -- Richards, R -- New York, N.Y. -- Science. 1984 Mar 30;223(4643):1435-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6701530" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Animals ; Arteriosclerosis/physiopathology ; Catecholamines/analysis ; Cattle ; Coronary Vasospasm/*physiopathology ; Coronary Vessels/analysis/drug effects/*physiopathology ; Female ; Histamine/*analysis/pharmacology ; Humans ; Male ; Middle Aged ; Norepinephrine/pharmacology ; Serotonin/analysis/pharmacology
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    A novel nuclear form of estradiol receptor in MCF-7 human breast cancer cells (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-09-14
    Description: Nuclear estrogen receptor from MCF-7 cells undergoes a time-dependent, hormone-inducible transformation to a form that is less extractable from nuclei and less exchangeable with ligand. This receptor-modifying, intranuclear event is independent of receptor loss (processing) and appears associated with hormone responsiveness (progesterone-receptor induction) in these cells. The magnitude of receptor loss, however, is variable and apparently not a prerequisite for hormone action to induce progesterone receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kasid, A -- Strobl, J S -- Huff, K -- Greene, G L -- Lippman, M E -- New York, N.Y. -- Science. 1984 Sep 14;225(4667):1162-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6474170" target="_blank"〉PubMed〈/a〉
    Keywords: Breast Neoplasms/*metabolism ; Cell Nucleus/metabolism ; Cells, Cultured ; Female ; Humans ; Receptors, Estradiol ; Receptors, Estrogen/*metabolism ; Receptors, Progesterone/biosynthesis ; Time Factors
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    Evidence for cholinergic neurites in senile plaques (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-12-21
    Description: In the neocortices and amygdalae of young and aged macaques, cholinergic axons were identified by means of a monoclonal antibody to bovine choline acetyltransferase. Many fine, linear, immunoreactive profiles were seen in these animals. In the older animals, some cholinergic axons showed multifocal enlargements along their course. In some instances, neurites with choline acetyltransferase immunoreactivity were associated with deposits of amyloid (visualized with thioflavin T fluorescence). The appearance of these amyloid-associated abnormal cholinergic processes was similar to that of neurites in senile plaques, as shown by conventional silver impregnation techniques. Cholinergic systems thus give rise to some of the neurites within senile plaques.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kitt, C A -- Price, D L -- Struble, R G -- Cork, L C -- Wainer, B H -- Becher, M W -- Mobley, W C -- NS 07179/NS/NINDS NIH HHS/ -- NS 10580/NS/NINDS NIH HHS/ -- NS 15721/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 Dec 21;226(4681):1443-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6505701" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Amygdala/enzymology/*pathology ; Amyloid/analysis ; Animals ; Antibodies, Monoclonal ; Axons/enzymology ; Cerebral Cortex/enzymology/*pathology ; Choline O-Acetyltransferase/analysis ; Female ; Humans ; Macaca mulatta ; Male ; Nerve Endings/enzymology ; Parasympathetic Nervous System/enzymology/*pathology
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    NIMH study finds one in five have disorders (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-10-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):324.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6484573" target="_blank"〉PubMed〈/a〉
    Keywords: Female ; Humans ; Male ; Mental Disorders/*epidemiology/therapy ; National Institute of Mental Health (U.S.) ; United States
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    Initiation of angiogenesis by human follicular fluid (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-04-27
    Description: Angiogenesis was observed and measured after injection of human follicular fluid into rabbit corneas. Undiluted human follicular fluid stimulated angiogenesis in every case, with new blood vessels visible 3 days after injection and extending 2.0 millimeters from the corneal scleral limbus into the injection site by day 15. Stimulation of angiogenesis was lost by heating or diluting the follicular fluid but was retained after charcoal stripping or dialysis. Human follicular fluid contains an angiogenic factor that may be associated with perifollicular neovascularization during folliculogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frederick, J L -- Shimanuki, T -- diZerega, G S -- New York, N.Y. -- Science. 1984 Apr 27;224(4647):389-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6200930" target="_blank"〉PubMed〈/a〉
    Keywords: Angiogenesis Inducing Agents/*analysis ; Animals ; Body Fluids/*analysis ; Chorionic Gonadotropin/pharmacology ; Cornea/blood supply ; Dialysis ; Female ; Growth Substances/*analysis ; Hot Temperature ; Humans ; Menstruation ; *Neovascularization, Pathologic ; Ovarian Follicle/*analysis ; Rabbits
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    Intrahippocampal septal grafts ameliorate learning impairments in aged rats (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-08-03
    Description: Grafts of fetal septal tissue rich in cholinergic neurons were implanted as a dissociated cell suspension into the depth of the hippocampal formation in aged rats with severe impairments in spatial learning abilities. After 2 1/2 to 3 months, the rats with grafts, but not the controls, had improved their performance in a spatial learning test. Their improvement was due, at least in part, to an increased ability to use spatial cues in the task. In all animals the grafts had produced an extensive acetylcholinesterase-positive terminal network in the surrounding host hippocampal formation. Thus, the action of cholinergic neurons in the graft onto elements in the host hippocampal circuitry may be a necessary, but perhaps not sufficient, prerequisite for the observed functional recovery.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gage, F H -- Bjorklund, A -- Stenevi, U -- Dunnett, S B -- Kelly, P A -- AG 03766/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 3;225(4661):533-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6539949" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Disease Models, Animal ; Female ; Fetus ; Hippocampus/embryology/growth & development/*transplantation ; Humans ; *Learning ; Memory Disorders/*physiopathology ; Rats ; Rats, Inbred Strains
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    Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-05-04
    Description: Peripheral blood lymphocytes from patients with the acquired immunodeficiency syndrome (AIDS) or with signs or symptoms that frequently precede AIDS (pre-AIDS) were grown in vitro with added T-cell growth factor and assayed for the expression and release of human T-lymphotropic retroviruses (HTLV). Retroviruses belonging to the HTLV family and collectively designated HTLV-III were isolated from a total of 48 subjects including 18 of 21 patients wih pre-AIDS, three of four clinically normal mothers of juveniles with AIDS, 26 of 72 adult and juvenile patients with AIDS, and from one of 22 normal male homosexual subjects. No HTLV-III was detected in or isolated from 115 normal heterosexual subjects. The number of HTLV-III isolates reported here underestimates the true prevalence of the virus since many specimens were received in unsatisfactory condition. Other data show that serum samples from a high proportion of AIDS patients contain antibodies to HTLV-III. That these new isolates are members of the HTLV family but differ from the previous isolates known as HTLV-I and HTLV-II is indicated by their morphological, biological, and immunological characteristics. These results and those reported elsewhere in this issue suggest that HTLV-III may be the primary cause of AIDS.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallo, R C -- Salahuddin, S Z -- Popovic, M -- Shearer, G M -- Kaplan, M -- Haynes, B F -- Palker, T J -- Redfield, R -- Oleske, J -- Safai, B -- New York, N.Y. -- Science. 1984 May 4;224(4648):500-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6200936" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/blood/*microbiology ; Adult ; Antigens, Viral/analysis ; Cells, Cultured ; Cytopathogenic Effect, Viral ; Deltaretrovirus/*isolation & purification/physiology/ultrastructure ; Female ; Homosexuality ; Humans ; Immune Sera/pharmacology ; Interferon Type I/immunology ; Male ; RNA-Directed DNA Polymerase/metabolism ; Risk ; T-Lymphocytes/microbiology
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    Purified human granulocyte-macrophage colony-stimulating factor: direct action on neutrophils (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-12-14
    Description: Neutrophil migration inhibition factor from T lymphocytes (NIF-T) is a lymphokine that acts to localize granulocytes. Medium conditioned by the Mo human T-lymphoblast cell line was used to purify NIF-T, a glycoprotein with a molecular weight of 22,000. The NIF-T was found to potently stimulate the growth of granulocyte and macrophage colonies from human bone marrow and colony formation by the KG-1 myeloid leukemia cell line. Thus a human lymphokine (NIF-T) that modulates the activities of mature neutrophilic granulocytes is also a colony-stimulating factor acting on precursors to induce growth and differentiation of new effector cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gasson, J C -- Weisbart, R H -- Kaufman, S E -- Clark, S C -- Hewick, R M -- Wong, G G -- Golde, D W -- CA 30280/CA/NCI NIH HHS/ -- CA 30388/CA/NCI NIH HHS/ -- CA 32737/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 Dec 14;226(4680):1339-42.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6390681" target="_blank"〉PubMed〈/a〉
    Keywords: Bone Marrow Cells ; Cell Division ; Cell Line ; Chromatography, High Pressure Liquid ; Colony-Stimulating Factors/*isolation & purification ; Electrophoresis, Polyacrylamide Gel ; Granulocytes/*cytology ; Humans ; Leukocyte Migration-Inhibitory Factors/*pharmacology ; Lymphokines/*pharmacology ; Macrophages/*cytology ; Molecular Weight
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    Mating and pregnancy can occur in genetically hypogonadal mice with preoptic area brain grafts (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-08-31
    Description: Adult female hypogonadal mice, in whom hypogonadism is secondary to a genetic deficiency in hypothalamic gonadotropin-releasing hormone (GnRH), are infertile. Mating, pregnancy, and delivery of healthy litters were achieved after transplantation of normal fetal preoptic area tissue, a major site of GnRH-containing cell bodies, into the third ventricle of adult female hypogonadal mice. Immunocytochemistry revealed GnRH-containing neurons in the grafts and GnRH-containing processes extending to the lateral median eminence of the host brains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gibson, M J -- Krieger, D T -- Charlton, H M -- Zimmerman, E A -- Silverman, A J -- Perlow, M J -- 1RO1NS20335/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):949-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6382608" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Chemistry ; Cerebral Ventricles/pathology ; *Copulation ; Female ; Hypogonadism/genetics/pathology/*physiopathology ; Infertility, Female/etiology/*therapy ; Male ; Mice ; Neurons/analysis ; Ovulation ; Pituitary Hormone-Releasing Hormones/analysis/*deficiency ; Pregnancy ; Preoptic Area/*transplantation ; *Reproduction
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    Cigarette craving, smoking withdrawal, and clonidine (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-11-16
    Description: Clonidine, an alpha-2-adrenergic agonist, significantly reduces opiate withdrawal. Fifteen heavy smokers abstained from cigarettes on three separate occasions and received instead clonidine, placebo, or the benzodiazepine alprazolam. Clonidine and alprazolam diminished withdrawal symptoms. The two drugs suppressed anxiety, tension, irritability, and restlessness equally but clonidine had a greater effect than alprazolam on cigarette craving. These observations suggest that noradrenergic activity is a common feature in the pathophysiology of withdrawal and that a special relationship exists between central noradrenergic activity and craving.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Glassman, A H -- Jackson, W K -- Walsh, B T -- Roose, S P -- Rosenfeld, B -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):864-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6387913" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Alprazolam ; Anxiety/drug therapy ; Benzodiazepines/therapeutic use ; Clinical Trials as Topic ; Clonidine/*therapeutic use ; Double-Blind Method ; Female ; Humans ; Male ; *Smoking ; Substance Withdrawal Syndrome/*drug therapy
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    Cytomegalovirus replicates in differentiated but not in undifferentiated human embryonal carcinoma cells (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-04-13
    Description: To study the mode of action of human cytomegalovirus, an important teratogenic agent in human populations, the susceptibility of a pluripotent human embryonal carcinoma cell line to the virus was investigated. Viral antigens were not expressed nor was infectious virus produced by human embryonal carcinoma cells after infection, although the virus was able to penetrate these cells. In contrast, retinoic acid-induced differentiated derivatives of embryonal carcinoma cells were permissive for antigen expression and infectious virus production. Replication of human cytomegalovirus in human teratocarcinoma cells may therefore depend on cellular functions associated with differentiation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gonczol, E -- Andrews, P W -- Plotkin, S A -- AI-14927/AI/NIAID NIH HHS/ -- CA-29894/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Apr 13;224(4645):159-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322309" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Cell Transformation, Neoplastic/drug effects/metabolism ; Cell Transformation, Viral/drug effects ; Cytomegalovirus/*physiology ; Embryonal Carcinoma Stem Cells ; Humans ; Neoplastic Stem Cells/*microbiology ; Stem Cells/*microbiology ; Teratoma/*microbiology ; Tretinoin/pharmacology ; *Virus Replication
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    Neuroendocrine response to estrogen and sexual orientation (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-09-28
    Description: A neuroendocrine component, the positive estrogen feedback effect, thought to be related to sexual orientation and, indirectly, to sexual differentiation, was evaluated in healthy, noninstitutionalized research volunteers. Men and women with a lifelong heterosexual orientation and men with a lifelong homosexual orientation were administered an estrogen preparation known to enhance the concentration of luteinizing hormone in women but not in men. The secretory pattern of luteinizing hormone in the homosexuals in response to estrogen was intermediate between that of the heterosexual men and that of the women. Furthermore, testosterone was depressed for a significantly longer period in the homosexual men than in the heterosexual men. These findings suggest that biological markers for sexual orientation may exist.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gladue, B A -- Green, R -- Hellman, R E -- MH-37412/MH/NIMH NIH HHS/ -- RR-05835-03/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1984 Sep 28;225(4669):1496-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6089349" target="_blank"〉PubMed〈/a〉
    Keywords: Estrogens, Conjugated (USP)/*pharmacology ; Estrone/*blood ; Female ; *Homosexuality ; Humans ; Luteinizing Hormone/*blood ; Male ; Sex Factors ; *Sexual Behavior ; Testosterone/*blood ; Time Factors
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    Detection of c-sis transcripts and synthesis of PDGF-like proteins by human osteosarcoma cells (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-11-23
    Description: Platelet-derived growth factor (PDGF) has been previously shown to be homologous to the transforming gene of simian sarcoma virus (v-sis), and inappropriate expression of the cellular counterpart of the v-sis gene (c-sis) has been implicated in the generation of mesenchymal tumors. The U-2 OS human osteosarcoma line was shown to contain multiple c-sis transcripts. Immunoprecipitation experiments with antiserum to PDGF identified a variety of polypeptides ranging in size from 18,000 to 165,000 daltons that were immunoprecipitated specifically from U-2 OS cell extracts. The osteosarcoma also was shown to secrete a 29,000-dalton protein having the serological and structural characteristics of PDGF.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Graves, D T -- Owen, A J -- Barth, R K -- Tempst, P -- Winoto, A -- Fors, L -- Hood, L E -- Antoniades, H N -- CA30101/CA/NCI NIH HHS/ -- HL27607/HL/NHLBI NIH HHS/ -- HL29583/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Nov 23;226(4677):972-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6209798" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; DNA Replication ; Humans ; Molecular Weight ; Neoplasm Proteins/*genetics ; *Oncogenes ; Osteosarcoma/*genetics ; *Platelet-Derived Growth Factor ; Poly A/genetics/isolation & purification ; RNA/genetics/isolation & purification ; RNA, Messenger ; *Transcription, Genetic
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    Defect in phosphorylation of insulin receptors in cells from an insulin-resistant patient with normal insulin binding (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-03-02
    Description: Mononuclear blood cells were obtained from a patient with type A insulin resistance. The cells showed a normal ability to bind iodine 125-labeled insulin. Analysis of solubilized insulin receptors from the patient's cells revealed a defect in insulin-stimulated tyrosine kinase activity, which is closely associated with the receptor itself. The enzyme failed to phosphorylate the insulin receptor and showed a markedly reduced ability to phosphorylate exogenously added substrates. It appears that receptors from this insulin-resistant patient have a defect distal to the insulin-binding site (the alpha subunit of the receptor). The defect could be located in the beta subunit, which has an adenosine triphosphate-binding site, or in another receptor component that transfers a signal of insulin binding into kinase activity. This dissociation between the normal binding and the defective protein kinase component of the insulin receptor represents the first biochemical defect of the receptor distal to ligand binding.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grunberger, G -- Zick, Y -- Gorden, P -- New York, N.Y. -- Science. 1984 Mar 2;223(4639):932-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6141638" target="_blank"〉PubMed〈/a〉
    Keywords: Caseins/metabolism ; Female ; Glutamates/metabolism ; Glutamic Acid ; Humans ; Insulin/blood/*metabolism ; *Insulin Resistance ; Monocytes/metabolism ; Phosphorylation ; Protein Kinases/*metabolism ; Receptor, Insulin/*metabolism ; Syndrome ; Tyrosine/metabolism
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    Activated expression of the N-myc gene in human neuroblastomas and related tumors (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-12-14
    Description: In neuroblastoma lines in which the N-myc gene is present as a single copy, the expression of N-myc as messenger RNA is increased relative to that in nonneuroblastoma cell lines and tumors. The increase of expression in neuroblastomas with amplified N-myc genes is the result of (i) an increase in the absolute amount of expression of each N-myc gene and (ii) an increase in the copy number of the N-myc gene. A second gene--which is amplified in many of the same lines as N-myc--is expressed to about the same degree in most human cell lines and primary tumors regardless of origin (when normalized to gene copy number). Thus, a change in the regulation of N-myc expression in neuroblastomas and certain other tumors results in greatly increased expression of each N-myc gene copy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kohl, N E -- Gee, C E -- Alt, F W -- 2-P01 CA 23767-06/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Dec 14;226(4680):1335-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6505694" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; *Gene Amplification ; Gene Expression Regulation ; Humans ; Neuroblastoma/*genetics ; *Oncogenes ; RNA, Messenger/metabolism
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    Studying learning in the womb (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-07-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1984 Jul 20;225(4659):302-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6740312" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Fetus/*physiology ; Humans ; Infant, Newborn ; Infant, Premature ; Learning/*physiology ; Male ; Pregnancy ; Rats
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    New neurons form in adulthood (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1984 Jun 22;224(4655):1325-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6729456" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Brain/physiology ; Canaries/physiology ; Female ; Fishes ; Humans ; Male ; Neurons/*physiology ; Rodentia
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  • 67
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    Calcium source for excitation-contraction coupling in myocardium of nonhibernating and hibernating chipmunks (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-10
    Description: The amplitude of the early plateau phase of the action potential and the slow action potential of cardiac muscle were much lower in hibernating chipmunks than in nonhibernating chipmunks. The frequency-dependent contraction was decreased in hibernating animals but increased in nonhibernating animals. Caffeine caused a negative inotropic effect in hibernating animals but a positive inotropic effect in nonhibernating animals. Ryanodine caused greater inhibition in hibernating animals than in nonhibernating animals. These results suggest that the respective roles of the sources of calcium for cardiac excitation-contraction coupling are changed during hibernation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kondo, N -- Shibata, S -- New York, N.Y. -- Science. 1984 Aug 10;225(4662):641-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6740332" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Animals ; Caffeine/pharmacology ; Calcium/metabolism/*physiology ; Cell Membrane/metabolism ; Female ; Heart/drug effects ; *Hibernation ; Male ; *Myocardial Contraction/drug effects ; Sciuridae/metabolism/*physiology
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  • 68
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    Antigens encoded by the 3'-terminal region of human T-cell leukemia virus: evidence for a functional gene (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-05
    Description: Antibodies in sera from patients with adult T-cell leukemia-lymphoma or from healthy carriers of type I human T-cell leukemia virus (HTLV) recognize an antigen of approximately 42 kilodaltons (p42) in cell lines infected with HTLV-I. Radiolabel sequence analysis of cyanogen bromide fragments of p42 led to the conclusion that this antigen is encoded in part by LOR, a conserved portion of the "X" region that is flanked by the envelope gene and the 3' long terminal repeat of HTLV-I. It is possible that this novel product mediates the unique transformation properties of the HTLV family.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, T H -- Coligan, J E -- Sodroski, J G -- Haseltine, W A -- Salahuddin, S Z -- Wong-Staal, F -- Gallo, R C -- Essex, M -- 2-T32-CA0903/CA/NCI NIH HHS/ -- CA07094/CA/NCI NIH HHS/ -- CA13885/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 Oct 5;226(4670):57-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6089350" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Antigens, Viral/*genetics ; Base Sequence ; Cell Line ; Cyanogen Bromide ; Deltaretrovirus/*genetics/immunology ; *Genes, Viral ; Humans ; Peptide Fragments ; Trans-Activators ; Viral Proteins/*genetics
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  • 69
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    Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-24
    Description: Infectious retroviruses have been detected in 22 of 45 randomly selected patients with acquired immune deficiency syndrome (AIDS) and in other individuals from San Francisco. The AIDS-associated retroviruses (ARV) studied in detail had a type D morphology, Mg2+-dependent reverse transcriptase, and cytopathic effects on lymphocytes. The viruses can be propagated in an established adult human T cell line, HUT-78. They cross-react with antiserum to the lymphadenopathy-associated retrovirus isolated from AIDS patients in France. Antibodies to ARV were found in all 86 AIDS patients and in a high percentage of 88 other homosexual men in San Francisco. This observation indicates the widespread presence of these lymphocytopathic retroviruses and their close association with AIDS.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levy, J A -- Hoffman, A D -- Kramer, S M -- Landis, J A -- Shimabukuro, J M -- Oshiro, L S -- CA-34980/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 24;225(4664):840-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6206563" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/immunology/*microbiology ; Antibodies, Viral/analysis ; Bone Marrow/microbiology ; California ; Cell Line ; Cells, Cultured ; Cross Reactions ; Cytopathogenic Effect, Viral ; Deltaretrovirus/immunology/*isolation & purification/physiology/ultrastructure ; *Homosexuality ; Humans ; Leukocytes/microbiology ; Lymphatic Diseases/immunology ; Male ; RNA-Directed DNA Polymerase/metabolism ; Syndrome ; T-Lymphocytes ; Virus Cultivation
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    Expression cloning of human EGF receptor complementary DNA: gene amplification and three related messenger RNA products in A431 cells (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-25
    Description: In order to further define the mechanisms by which polypeptide growth factors regulate gene transcription and cellular growth, expression cloning techniques were used to select human epidermal growth factor (EGF) receptor complementary DNA clones. The EGF 3' coding domain shows striking homology to the transforming gene product of avian erythroblastosis virus (v-erbB). Over-expression of EGF receptors in A431 cell lines correlates with increased EGF receptor mRNA levels and amplification (up to 110 times) of the apparently singular EGF receptor gene. There appear to be three cytoplasmic polyadenylated RNA products of EGF receptor gene expression in A431 cells, one of which contains only 5' (EGF binding domain) sequences and is postulated to encode the secreted EGF receptor-related protein.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, C R -- Chen, W S -- Kruiger, W -- Stolarsky, L S -- Weber, W -- Evans, R M -- Verma, I M -- Gill, G N -- Rosenfeld, M G -- New York, N.Y. -- Science. 1984 May 25;224(4651):843-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6326261" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Cell Line ; Cloning, Molecular ; DNA/*genetics ; Gene Amplification ; Gene Expression Regulation ; Polymorphism, Genetic ; RNA, Messenger/genetics ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/*genetics
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    Transfection of the DNA polymerase-alpha gene (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-16
    Description: DNA polymerase-alpha is the major replicative DNA polymerase in animal cells. The gene coding for a mutant DNA polymerase-alpha was transferred from one cell to another by transfection of DNA from mutant cells. The DNA was isolated from a mutant hamster cell line resistant to aphidicolin, a specific inhibitor of DNA polymerase-alpha, and transferred into an aphidicolin-sensitive cell line. The resulting transfectants exhibited increased survival in the presence of aphidicolin and contained an aphidicolin-resistant DNA polymerase-alpha.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, P K -- Loeb, L A -- CA07418/CA/NCI NIH HHS/ -- CA24845/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):833-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6436977" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aphidicolin ; Cell Line ; Clone Cells ; Cricetinae ; Cricetulus/genetics ; DNA Polymerase II/*genetics ; Diterpenes/pharmacology ; Escherichia coli/genetics ; Humans ; Mice ; Mutation ; Salmon/genetics ; *Transfection
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    Prenatal exposure to carbon monoxide: learning and memory deficits (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-01-27
    Description: Exposing pregnant rats to carbon monoxide (150 parts per million) produced only minor reductions in the birth weights of the pups and gave no evidence of overt teratogenesis. However, behavioral evaluation of learning and memory processes in a two-way avoidance task suggested a functional deficit in the central nervous system of the exposed offspring. Multiple dependent measures and specific control groups confirmed that this deficit was independent of nonassociative or motivational alterations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mactutus, C F -- Fechter, L D -- ES 01589/ES/NIEHS NIH HHS/ -- ES 07094/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 27;223(4634):409-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6691152" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Avoidance Learning/*drug effects ; Birth Weight/drug effects ; Carbon Monoxide/*toxicity ; Conditioning (Psychology) ; Female ; Male ; Memory/*drug effects ; Pregnancy ; *Prenatal Exposure Delayed Effects ; Rats
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  • 73
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    Simian AIDS: isolation of a type D retrovirus and transmission of the disease (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-09
    Description: A type D retrovirus related to but distinct from Mason-Pfizer monkey virus was isolated in vitro from the blood of two rhesus monkeys (Macaca mulatta) with simian acquired immunodeficiency syndrome (SAIDS). Three juvenile rhesus monkeys that were injected intravenously with tissue culture fluids containing this virus developed SAIDS after 2 to 4 weeks.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, P A -- Maul, D H -- Osborn, K G -- Lerche, N W -- Moody, P -- Lowenstine, L J -- Henrickson, R V -- Arthur, L O -- Gilden, R V -- Gravell, M -- AI20573-01/AI/NIAID NIH HHS/ -- N01-CO-23910/CO/NCI NIH HHS/ -- RR00169/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1083-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695196" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/microbiology/transmission/*veterinary ; Animals ; Antigens, Viral/immunology ; Disease Models, Animal ; Female ; Macaca/*microbiology ; Macaca mulatta/*microbiology ; Male ; Retroviridae/immunology/*isolation & purification/ultrastructure ; Viral Core Proteins ; Viral Envelope Proteins/immunology ; Viral Proteins/immunology
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    Dioxin in soil: bioavailability after ingestion by rats and guinea pigs (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-09
    Description: Soil environmentally contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was given by gavage to guinea pigs and rats. The development of a characteristic clinicopathologic syndrome in guinea pigs, the induction of aryl hydrocarbon hydroxylase in rats, and the presence of TCDD in the livers of both species show that TCDD in soil exhibits high biological availability after ingestion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McConnell, E E -- Lucier, G W -- Rumbaugh, R C -- Albro, P W -- Harvan, D J -- Hass, J R -- Harris, M W -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1077-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695194" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aryl Hydrocarbon Hydroxylases/biosynthesis ; Biological Availability ; Body Weight/drug effects ; Cytochrome P-450 Enzyme System/metabolism ; Dioxins/*metabolism ; Eating ; Enzyme Induction ; Female ; Guinea Pigs ; Intestinal Absorption ; Liver/drug effects ; Male ; Microsomes, Liver/enzymology ; Organ Size/drug effects ; Rats ; Rats, Inbred Strains ; *Soil Pollutants/toxicity ; Tetrachlorodibenzodioxin/*metabolism/toxicity ; Thymus Gland/drug effects
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    Proliferation of astroglia and oligodendroglia in response to human T cell-derived factors (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-29
    Description: Human T lymphocytes transformed by human T cell leukemia-lymphoma viruses or activated by lectins were found to produce stimulating factors that promoted both proliferation and maturation of oligodendroglial and astroglial cells in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Merrill, J E -- Kutsunai, S -- Mohlstrom, C -- Hofman, F -- Groopman, J -- Golde, D W -- CA 30388/CA/NCI NIH HHS/ -- CA 32737/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 29;224(4656):1428-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6610212" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Astrocytes/*drug effects ; Cell Division/*drug effects ; Cell Line ; Growth Substances/*pharmacology ; Humans ; Lymphocyte Activation ; Lymphokines/pharmacology ; Neuroglia/*drug effects ; Oligodendroglia/*drug effects ; Rats ; Receptors, Fc/metabolism ; T-Lymphocytes/*physiology
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  • 76
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    Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-04-27
    Description: The sequence of the human epidermal growth factor (EGF) receptor shows great homology with the avian erythroblastosis virus v-erb B oncogene, raising the possibility that the receptor gene is identical to the c-erb B protooncogene. Human A431 epidermoid carcinoma cells, which have an unusually high number of EGF receptors, were examined to determine whether elevated EGF receptor levels correlate with gene amplification. Southern blots of genomic DNA's from A431 and other human cell lines were probed with either a v-erb B gene fragment or a human EGF receptor complementary DNA clone (pE7), previously isolated from an A431 complementary DNA library. When either probe was used to analyze Eco RI- or Hind III-generated DNA fragments, EGF receptor DNA sequences were amplified about 30-fold in A431. Differences in the banding pattern of A431 DNA fragments relative to normal fibroblast DNA indicate the occurrence of a rearrangement in the region of the receptor gene. Furthermore, A431 cells contain a characteristic, prominent 2.9-kilobase RNA. These results are consistent with the hypothesis that, in A431 cells, gene amplification, possibly associated with a translocation event, may result in the overproduction of EGF receptor protein or the appearance of the transformed phenotype (or both).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Merlino, G T -- Xu, Y H -- Ishii, S -- Clark, A J -- Semba, K -- Toyoshima, K -- Yamamoto, T -- Pastan, I -- New York, N.Y. -- Science. 1984 Apr 27;224(4647):417-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6200934" target="_blank"〉PubMed〈/a〉
    Keywords: Alpharetrovirus/genetics ; Base Sequence ; Carcinoma, Squamous Cell ; Cell Line ; Dna ; DNA Restriction Enzymes ; Epidermal Growth Factor/metabolism ; *Gene Amplification ; Genes, Viral ; Humans ; Nucleic Acid Hybridization ; Oncogenes ; Poly A/genetics ; RNA/genetics ; RNA, Messenger ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/biosynthesis/*genetics ; Translocation, Genetic
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    Inhibitors of poly(adenosine diphosphate-ribose) synthesis: effect on other metabolic processes (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-02-10
    Description: 3-Aminobenzamide and benzamide, purported to be specific inhibitors of the synthesis of poly(adenosine diphosphate-ribose), were used to elucidate possible functions of this biopolymer. These compounds, at frequently used experimental concentrations, not only inhibited the action of poly(adenosine diphosphate-ribose) synthetase but also affected cell viability, glucose metabolism, and DNA synthesis. Thus, the usefulness of 3-aminobenzamide and benzamide may be severely restricted by the difficulty of finding a dose small enough to inhibit the synthetase without producing additional metabolic effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Milam, K M -- Cleaver, J E -- New York, N.Y. -- Science. 1984 Feb 10;223(4636):589-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6420886" target="_blank"〉PubMed〈/a〉
    Keywords: Benzamides/*toxicity ; Cell Line ; DNA Replication/drug effects ; Humans ; Kinetics ; Lymphocytes ; Nucleoside Diphosphate Sugars/*biosynthesis ; Poly Adenosine Diphosphate Ribose/*biosynthesis ; Poly(ADP-ribose) Polymerases/metabolism ; Structure-Activity Relationship
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    Infectious and selectable retrovirus containing an inducible rat growth hormone minigene (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-09-07
    Description: A growth hormone minigene carrying its natural promoter (237 nucleotides of chromosomal DNA) was stably propagated in a murine retrovirus containing hypoxanthine-guanine phosphoribosyltransferase as a selectable marker. Glucocorticoid and thyroid hormone inducibility was transferred with the growth hormone gene. Recombinant virus with titers of 10(6) per milliliter was recovered. This demonstration that retroviruses can be used to transfer a nonselectable gene under its own regulatory control enlarges the scope of retroviral vectors as potent tools for gene transfer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, A D -- Ong, E S -- Rosenfeld, M G -- Verma, I M -- Evans, R M -- New York, N.Y. -- Science. 1984 Sep 7;225(4666):993-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6089340" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; DNA, Recombinant ; DNA, Viral/analysis ; Dexamethasone/pharmacology ; Gene Expression Regulation ; *Genes ; Genes, Viral ; Genetic Markers ; *Genetic Vectors ; Growth Hormone/biosynthesis/*genetics ; Hypoxanthine Phosphoribosyltransferase/genetics ; Mice ; Operon ; Phenotype ; RNA, Viral/genetics ; Rats ; Retroviridae/*genetics ; Transcription, Genetic ; Transfection ; Triiodothyronine/pharmacology
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  • 79
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    Adaptation of lymphadenopathy associated virus (LAV) to replication in EBV-transformed B lymphoblastoid cell lines (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-07-06
    Description: A strain of lymphadenopathy associated retrovirus ( LAV ) passaged in vitro was used to infect a lymphoblastoid cell line obtained by transformation with Epstein-Barr virus of B lymphocytes from a healthy donor. The virus produced from this line (B- LAV ) was also able to grow at a high rate in some other lymphoblastoid lines and in a Burkitt lymphoma line. This adapted strain retained the biochemical, ultrastructural, and antigenic characteristics of the original strain, as well as its tropism for normal T4+ lymphocytes. It is thus possible to grow LAV in large quantities that can be used for the preparation of diagnostic reagents. The interaction between such a human retrovirus and Epstein-Barr virus, a DNA virus, may have some implication for the pathology of the acquired immunodeficiency syndrome and related diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Montagnier, L -- Gruest, J -- Chamaret, S -- Dauguet, C -- Axler, C -- Guetard, D -- Nugeyre, M T -- Barre-Sinoussi, F -- Chermann, J C -- Brunet, J B -- New York, N.Y. -- Science. 1984 Jul 6;225(4657):63-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6328661" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/microbiology ; Antibodies, Monoclonal/immunology ; B-Lymphocytes/*microbiology ; Cell Line ; Cell Transformation, Viral ; Deltaretrovirus/metabolism ; Herpesvirus 4, Human/*metabolism ; Humans ; Retroviridae/*growth & development ; T-Lymphocytes/microbiology ; *Virus Replication
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    Autoimmunity and increased c-myb transcription (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-30
    Description: A single recessive gene, lpr, induces an autoimmune-lymphoproliferative syndrome in several strains of mice. The lymphoid organs of lpr/lpr mice contained cells with increased amounts of myb RNA, which codes for a protein found in the nucleus. A similar human lymphoproliferative disorder also had an increase in c-myb expression. Mouse T cells induced by mitogens to proliferate did not express large amounts of myb RNA, indicating that marked myb expression is not a general feature of lymphocyte activation and proliferation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mountz, J D -- Steinberg, A D -- Klinman, D M -- Smith, H R -- Mushinski, J F -- New York, N.Y. -- Science. 1984 Nov 30;226(4678):1087-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494925" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoantibodies/*genetics ; Autoimmune Diseases/*genetics ; Female ; *Genes, Recessive ; Lymphocytes/immunology ; Lymphoproliferative Disorders/*genetics ; Mice ; Mice, Inbred Strains ; Nucleic Acid Hybridization ; *Oncogenes ; Species Specificity ; Spleen/immunology ; *Transcription, Genetic
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  • 81
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    Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-12-14
    Description: The possibility that hypersecretion of corticotropin-releasing factor (CRF) contributes to the hyperactivity of the hypothalamo-pituitary-adrenal axis observed in patients with major depression was investigated by measuring the concentration of this peptide in cerebrospinal fluid of normal healthy volunteers and in drug-free patients with DSM-III diagnoses of major depression, schizophrenia, or dementia. When compared to the controls and the other diagnostic groups, the patients with major depression showed significantly increased cerebrospinal fluid concentrations of CRF-like immunoreactivity; in 11 of the 23 depressed patients this immunoreactivity was greater than the highest value in the normal controls. These findings are concordant with the hypothesis that CRF hypersecretion is, at least in part, responsible for the hyperactivity of the hypothalamo-pituitary-adrenal axis characteristic of major depression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nemeroff, C B -- Widerlov, E -- Bissette, G -- Walleus, H -- Karlsson, I -- Eklund, K -- Kilts, C D -- Loosen, P T -- Vale, W -- MH-36157/MH/NIMH NIH HHS/ -- MH-39415/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1984 Dec 14;226(4680):1342-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6334362" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Corticotropin-Releasing Hormone/*cerebrospinal fluid ; Dementia/cerebrospinal fluid ; Depressive Disorder/*cerebrospinal fluid ; Female ; Humans ; Male ; Middle Aged ; Radioimmunoassay ; Schizophrenia/cerebrospinal fluid
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  • 82
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    Ratio of serum urea to serum creatinine in wild black bears (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-16
    Description: In winter, the ratio of serum urea to serum creatinine is 10 or less in denning female and male bears. In midsummer it is 22 or more, similar to that of other mammals. However, in late summer and early fall, while food is available, the urea-to-creatinine ratio approaches or becomes 10 or less. The low value of this ratio appears to indicate the biochemical state of hibernation, and many bears are in this state weeks before they den.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nelson, R A -- Beck, T D -- Steiger, D L -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):841-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494914" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Population Groups/*blood ; Animals ; Animals, Wild/*blood/physiology ; Carnivora/*blood ; Creatinine/*blood ; Diet ; Female ; Food Supply ; Hibernation ; Male ; Seasons ; Urea/*blood ; Ursidae/*blood/physiology
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  • 83
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    Organ-specific adhesion of metastatic tumor cells in vitro (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-06-08
    Description: Binding of tumor cells to cryostat sections of host organs was studied. B16-F10 melanoma cells and reticulum cell sarcoma cells demonstrated an organ specificity in their binding in vitro that reflected the organ specificity of their metastatic distribution 25 days after intravenous injection. These results provide evidence for specific binding of tumor cells to the tissues that they selectively colonize in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Netland, P A -- Zetter, B R -- 5 T32 GM 07258/GM/NIGMS NIH HHS/ -- R01 CA 28540/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1113-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6372098" target="_blank"〉PubMed〈/a〉
    Keywords: Adhesiveness ; Animals ; Cell Line ; Humans ; Liver/physiopathology ; Lung/physiopathology ; Lymphoma, Large B-Cell, Diffuse/physiopathology ; Melanoma/physiopathology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Neoplasm Metastasis/physiopathology ; Neoplasms/*physiopathology ; Neoplasms, Experimental/physiopathology ; *Organ Specificity
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  • 84
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    Scoliosis in chickens: responsiveness of severity and incidence to dietary copper (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-07-27
    Description: The severity and incidence of spinal lesions were manipulated in a line of chickens susceptible to scoliosis by varying their dietary intake of copper. A decrease in expression of the lesion was related to increased intake of copper. The change in expression, however, appeared to be related only indirectly to the defects in collagen cross-linking, maturation, and deposition known to be associated with dietary copper deficiency. Thus, a dietary constituent in the range of normal intakes may act as an environmental factor in the expression of scoliosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Opsahl, W -- Abbott, U -- Kenney, C -- Rucker, R -- AM 25358/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1984 Jul 27;225(4660):440-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6740317" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chickens ; Collagen/physiology ; Copper/deficiency/*physiology ; *Diet ; Female ; Humans ; Male ; Scoliosis/*etiology ; Sex Factors
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  • 85
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    Lymphokine production by cultured human T cells transformed by human T-cell leukemia-lymphoma virus-I (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-02-17
    Description: Cell-free conditioned media from human T cells transformed by human T-cell leukemia-lymphoma virus (HTLV-I) were tested for the production of soluble biologically active factors, including several known lymphokines. The cell lines used were established from patients with T-cell leukemia-lymphoma and from human umbilical cord blood and bone marrow leukocytes transformed by HTLV-I in vitro. All of the cell lines liberated constitutively one or more of the 12 biological activities assayed. These included macrophage migration inhibitory factor (MIF), leukocyte migration inhibitory factor (LIF), leukocyte migration enhancing factor (MEF), macrophage activating factor (MAF), differentiation inducing factor (DIF), colony stimulating factor (CSF), eosinophil growth and maturation activity (eos. GMA), fibroblast activating factor (FAF), gamma-interferon and, in rare instances, T-cell growth factor (TCGF). Some cell lines produced interleukin 3 (IL-3), platelet-derived growth factor (PDGF), or B-cell growth factors (BCGF). Such cells should prove useful for the production of lymphokines and as sources of specific messenger RNA's for their genetic cloning.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Salahuddin, S Z -- Markham, P D -- Lindner, S G -- Gootenberg, J -- Popovic, M -- Hemmi, H -- Sarin, P S -- Gallo, R C -- New York, N.Y. -- Science. 1984 Feb 17;223(4637):703-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6320367" target="_blank"〉PubMed〈/a〉
    Keywords: Antibodies, Monoclonal ; Antigens, Neoplasm/analysis ; Bone Marrow ; Cell Line ; *Cell Transformation, Neoplastic ; Cells, Cultured ; Deltaretrovirus/*genetics ; Female ; Humans ; Leukemia/*microbiology ; Lymphokines/*biosynthesis ; Lymphoma/*microbiology ; Phenotype ; Pregnancy ; T-Lymphocytes/*immunology
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  • 86
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    Human T-cell leukemia virus (HTLV-I) antibodies in Africa (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-09-28
    Description: Antibodies specific for human T-cell leukemia-lymphoma virus type I (HTLV-I) were demonstrated in serum samples from various groups of people in South Africa, Uganda, Ghana, Nigeria, Tunisia, and Egypt. The samples had been collected for other purposes and were presumably selected without bias toward clinical conditions associated with HTLV infections. Regional differences in antibody positivity were observed, indicating widely distributed loci of occurrence of HTLV on the African continent in people of both black and white ancestry. Two patients with high titers of antibody to HTLV-I had some signs of adult T-cell leukemia-lymphoma. In several groups a high frequency of false positive serum reactions was indicated when specific confirmation steps were included in the assay. Further characterization of these sera revealed highly elevated immunoglobulin levels, possibly due to polyclonal activation of immunoglobulin synthesis in these subjects. The possibility that related cross-reactive human retroviruses coexist in the same groups was not eliminated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Saxinger, W -- Blattner, W A -- Levine, P H -- Clark, J -- Biggar, R -- Hoh, M -- Moghissi, J -- Jacobs, P -- Wilson, L -- Jacobson, R -- New York, N.Y. -- Science. 1984 Sep 28;225(4669):1473-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6089348" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Africa ; African Continental Ancestry Group ; Antibodies, Viral/*analysis ; Burkitt Lymphoma/immunology ; Cross Reactions ; Deltaretrovirus/*immunology ; Enzyme-Linked Immunosorbent Assay ; European Continental Ancestry Group ; False Positive Reactions ; Female ; Humans ; Lymphoma/immunology ; Male ; Middle Aged ; Retroviridae/immunology ; T-Lymphocytes
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  • 87
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    Treatment of a 12-hour shift of sleep schedule with benzodiazepines (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-06-15
    Description: Normal sleepers underwent sleep recordings and daytime tests of sleep tendency, performance, and mood while being shifted 180 degrees in their sleep-wake schedule. After two baseline 24-hour periods, subjects postponed sleep until noon. For the next three 24-hour periods, they were in bed from 1200 to 2000 and received triazolam, flurazepam, or placebo at bedtime in parallel groups. Placebo subjects showed significant sleep loss after the shift. Active medication reversed this sleep loss. Despite good sleep, flurazepam subjects appeared most impaired of the three groups on objective assessments of waking function; triazolam subjects were least impaired.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seidel, W F -- Roth, T -- Roehrs, T -- Zorick, F -- Dement, W C -- NIMH 05804/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 15;224(4654):1262-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6729454" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Arousal/drug effects ; Benzodiazepines/pharmacology/*therapeutic use ; Emotions/drug effects ; Female ; Flurazepam/pharmacology/therapeutic use ; Humans ; Male ; Sleep/drug effects ; Sleep Wake Disorders/*drug therapy ; Triazolam/pharmacology/therapeutic use
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  • 88
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    Opioid peptides mediate the suppressive effect of stress on natural killer cell cytotoxicity (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-01-13
    Description: The cytotoxic activity of natural killer cells was investigated in rats subjected to one of two inescapable footshock stress paradigms, both of which induce analgesia, but only one via activation of opioid mechanisms. Splenic natural killer cell activity was suppressed by the opioid, but not the nonopioid, form of stress. This suppression was blocked by the opioid antagonist naltrexone. Similar suppression of natural killer activity was induced by high doses of morphine. These results suggest that endogenous opioid peptides mediate the suppressive effect of certain forms of stress on natural killer cell cytotoxicity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shavit, Y -- Lewis, J W -- Terman, G W -- Gale, R P -- Liebeskind, J C -- MH15795/MH/NIMH NIH HHS/ -- NS07628/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 13;223(4632):188-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6691146" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cytotoxicity, Immunologic/drug effects ; Dose-Response Relationship, Drug ; Endorphins/*physiology ; Female ; Killer Cells, Natural/*immunology ; Morphine/*pharmacology ; Naltrexone/pharmacology ; Rats ; Rats, Inbred F344 ; Stress, Physiological/*immunology
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  • 89
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    Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-05-04
    Description: In cats, infection with T-lymphotropic retroviruses can cause T-cell proliferation and leukemia or T-cell depletion and immunosuppression. In humans, some highly T4 tropic retroviruses called HTLV-I can cause T-cell proliferation and leukemia. The subgroup HTLV-II also induces T-cell proliferation in vitro, but its role in disease is unclear. Viruses of a third subgroup of human T-lymphotropic retroviruses, collectively designated HTLV-III, have been isolated from cultured cells of 48 patients with acquired immunodeficiency syndrome (AIDS). The biological properties of HTLV-III and immunological analyses of its proteins show that this virus is a member of the HTLV family, and that it is more closely related to HTLV-II than to HTLV-I. Serum samples from 88 percent of patients with AIDS and from 79 percent of homosexual men with signs and symptoms that frequently precede AIDS, but from less than 1 percent of heterosexual subjects, have antibodies reactive against antigens of HTLV-III. The major immune reactivity appears to be directed against p41, the presumed envelope antigen of the virus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sarngadharan, M G -- Popovic, M -- Bruch, L -- Schupbach, J -- Gallo, R C -- New York, N.Y. -- Science. 1984 May 4;224(4648):506-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6324345" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*immunology/microbiology ; Adult ; Antibodies, Viral/*analysis ; Antigens, Viral/immunology ; Child, Preschool ; Deltaretrovirus/*immunology ; Enzyme-Linked Immunosorbent Assay ; Female ; Homosexuality ; Humans ; Infant ; Male ; Middle Aged ; Sarcoma, Kaposi/immunology ; Substance-Related Disorders ; T-Lymphocytes/microbiology ; Viral Envelope Proteins/immunology
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  • 90
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    Neuropeptides: mediators of behavior in Aplysia (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-09-21
    Description: The Aplysia neuroendocrine system is a particularly advantageous model for cellular and molecular studies because of the relatively small number and large size of its component neurons. Recombinant DNA techniques have been used to isolate the genes that encode the precursors of peptides expressed in identified neurons of known function. The organization and developmental expression of these genes have been examined in detail. Several of the genes encode precursors of multiple biologically active peptides that are expressed in cells which also contain classical transmitters. These studies, as well as immunohistochemical studies and the use of intracellular recording and voltage clamp techniques are the first steps toward revealing the mechanisms by which neuropeptides govern simple behaviors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Scheller, R H -- Kaldany, R R -- Kreiner, T -- Mahon, A C -- Nambu, J R -- Schaefer, M -- Taussig, R -- New York, N.Y. -- Science. 1984 Sep 21;225(4668):1300-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6474178" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aplysia/*physiology ; Behavior, Animal ; Cloning, Molecular ; DNA, Recombinant/metabolism ; Female ; Ganglia/physiology ; Genes ; Male ; Nerve Tissue Proteins/genetics/*physiology ; *Nervous System Physiological Phenomena ; Neurons/physiology ; Protein Biosynthesis ; Reproduction
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  • 91
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    Molecular characterization of human T-cell leukemia (lymphotropic) virus type III in the acquired immune deficiency syndrome (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-12-07
    Description: The human T-cell leukemia (lymphotropic) virus type III (HTLV-III) appears to be central to the causation of the acquired immune deficiency syndrome (AIDS). Two full-length integrated proviral DNA forms of HTLV-III have now been cloned and analyzed, and DNA sequences of the virus in cell lines and fresh tissues from patients with AIDS or AIDS-related complex (ARC) have been characterized. The results revealed that (i) HTLV-III is an exogenous human retrovirus, approximately 10 kilobases in length, that lacks nucleic acid sequences derived from normal human DNA; (ii) HTLV-III, unlike HTLV types I and II, shows substantial diversity in its genomic restriction enzyme cleavage pattern; (iii) HTLV-III persists in substantial amounts in cells as unintegrated linear DNA, an uncommon property that has been linked to the cytopathic effects of certain animal retroviruses; and (iv) HTLV-III viral DNA can be detected in low levels in fresh (primary) lymphoid tissue of a minority of patients with AIDS or ARC but appears not to be present in Kaposi's sarcoma tissue. These findings have important implications concerning the biological properties of HTLV-III and the pathophysiology of AIDS and Kaposi's sarcoma.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shaw, G M -- Hahn, B H -- Arya, S K -- Groopman, J E -- Gallo, R C -- Wong-Staal, F -- New York, N.Y. -- Science. 1984 Dec 7;226(4679):1165-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6095449" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*microbiology ; Base Sequence ; Cell Line ; Child ; Cloning, Molecular ; Cytopathogenic Effect, Viral ; DNA Restriction Enzymes/metabolism ; DNA, Viral/*analysis ; Deltaretrovirus/*genetics ; Humans ; Male ; Nucleic Acid Hybridization
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  • 92
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    Multicentric origin of colon carcinoma (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beutler, E -- New York, N.Y. -- Science. 1984 May 11;224(4649):630.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710162" target="_blank"〉PubMed〈/a〉
    Keywords: Colonic Neoplasms/*etiology/genetics ; Female ; Glucosephosphate Dehydrogenase/genetics ; Glucosephosphate Dehydrogenase Deficiency/genetics ; Humans
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  • 93
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    Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-08
    Description: A domain of DNA designated N-myc is amplified 20- to 140-fold in human neuroblastoma cell lines but not in cell lines from other tumor types. N-myc has now been found to be amplified in neuroblastoma tissue from 24 of 63 untreated patients (38 percent). The extent of amplification appears to be bimodal, with amplification of 100- to 300-fold in 12 cases and 3- to 10-fold in 10 others. Amplification was found in 0 of 15 patients with stage 1 or 2 disease, whereas 24 of 48 cases (50 percent) with stage 3 or 4 had evidence of N-myc amplification. These data indicate that N-myc amplification is a common event in untreated human neuroblastomas. Furthermore, N-myc amplification is highly correlated with advanced stages of disease (P less than 0.001) and with the ability to grow in vitro as an established cell line, both of which are associated with a poor prognosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brodeur, G M -- Seeger, R C -- Schwab, M -- Varmus, H E -- Bishop, J M -- CA02971/CA/NCI NIH HHS/ -- CA13539/CA/NCI NIH HHS/ -- CA17829/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1121-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6719137" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; Cell Line ; Child ; Child, Preschool ; DNA, Neoplasm/genetics ; Eye Neoplasms/genetics ; *Gene Amplification ; Humans ; Infant ; Lymphatic Metastasis ; Middle Aged ; Neuroblastoma/*genetics/physiopathology ; Nucleic Acid Hybridization ; *Oncogenes ; Prognosis ; Retinoblastoma/genetics
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  • 94
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    Prevalence of antibodies to lymphadenopathy-associated retrovirus in African patients with AIDS (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-26
    Description: The presence of antibodies to lymphadenopathy-associated retrovirus (LAV) was determined by a radioimmunoprecipitation assay and by an enzyme-linked immunosorbent solid assay of sera from Zairian patients with the acquired immune deficiency syndrome (AIDS) in 1983. Thirty-five of 37 patients (94 percent) and 32 of 36 patients (88 percent), respectively, were seropositive by the two tests. In a control group of 26 patients, six (23 percent) showed positive results in these tests. Of these six control patients, five had clinically demonstrable infectious diseases and a low ratio of T4 to T8 lymphocytes. In addition, sera collected from a control group of Zairian mothers in 1980 were positive for LAV in 5 of 100 cases. Other serologic data suggest that LAV was present as early as 1977 in Zaire.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brun-Vezinet, F -- Rouzioux, C -- Montagnier, L -- Chamaret, S -- Gruest, J -- Barre-Sinoussi, F -- Geroldi, D -- Chermann, J C -- McCormick, J -- Mitchell, S -- New York, N.Y. -- Science. 1984 Oct 26;226(4673):453-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6238406" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*immunology ; Antibodies, Viral/*analysis ; Democratic Republic of the Congo ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Lymphatic Diseases/*microbiology ; Male ; Radioimmunoassay ; Retroviridae/*immunology ; T-Lymphocytes, Helper-Inducer/cytology ; T-Lymphocytes, Regulatory/cytology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 95
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    O-acetylation of disialoganglioside GD3 by human melanoma cells creates a unique antigenic determinant (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-24
    Description: Monoclonal antibody Mab D1.1 recognizes on human melanoma cells a ganglioside antigen characterized by an alkali-labile O-acetylated sialic acid residue. Immunochemical analysis showed that this molecule is an O-acetylated product of the neuroectoderm-associated disialoganglioside GD3. Controlled chemical O-acetylation of purified GD3 resulted in the generation of this same epitope. Lysates of human melanoma cells were found to contain O-acetyltransferase activity capable of generating the antigenic epitope recognized by Mab D1.1. Thus, the addition of a single O-acetyl group to a common cell surface-associated ganglioside can create a potentially tumor-specific antigen.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cheresh, D A -- Reisfeld, R A -- Varki, A P -- CA 07544/CA/NCI NIH HHS/ -- CA 28420/CA/NCI NIH HHS/ -- GM32373/GM/NIGMS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 Aug 24;225(4664):844-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6206564" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylation ; Acetyltransferases/metabolism ; Antibodies, Monoclonal ; Antigens, Neoplasm/*immunology ; Cell Line ; Epitopes/immunology ; Gangliosides/analysis/*immunology/metabolism ; Humans ; Melanoma/enzymology/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 96
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    Potentiation of bleomycin lethality by anticalmodulin drugs: a role for calmodulin in DNA repair (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-22
    Description: Treatment of exponentially growing Chinese hamster ovary cells with bleomycin causes a dose-dependent decrease in cell survival due to DNA damage. This lethal effect can be potentiated by the addition of a nonlethal dose of the anticalmodulin drug N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide ( W13 ) but not its inactive analog N-(4-aminobutyl)-2-naphthalenesulfonamide ( W12 ). By preventing the repair of damaged DNA, W13 also inhibits recovery from potentially lethal damage induced by bleomycin. These data suggest a role for calmodulin in the DNA repair pathway.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chafouleas, J G -- Bolton, W E -- Means, A R -- RR-05425/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 22;224(4655):1346-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6203171" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bleomycin/*pharmacology ; Calmodulin/*antagonists & inhibitors/*physiology ; Cell Division/drug effects ; Cell Line ; Cell Survival/drug effects ; Cricetinae ; Cricetulus ; DNA Repair/*drug effects ; Dose-Response Relationship, Drug ; Drug Synergism ; Sulfonamides/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 97
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    Appearance of a new nucleosomal protein during differentiation of human leukemia (HL-60) cells (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-30
    Description: A 60-kilodalton protein was identified in chromatin digested by micrococcal nuclease during retinoic acid-induced differentiation of human leukemia (HL-60) cells to mature-like granulocytes. The protein was not detected in a retinoic acid-resistant variant of the HL-60 cell line treated with retinoic acid, in HL-60 cells induced with dimethyl sulfoxide, or in normal human granulocytes. This protein may have an important role in the regulation of retinoic acid-induced leukemic cell differentiation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chou, R H -- Chervenick, P A -- Barch, D R -- CA14278-08/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Mar 30;223(4643):1420-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6583846" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Cell Transformation, Neoplastic/drug effects ; Centrifugation, Density Gradient ; Dimethyl Sulfoxide/pharmacology ; Electrophoresis, Polyacrylamide Gel ; Granulocytes/metabolism ; Humans ; Leukemia, Myeloid, Acute/*metabolism ; Neoplasm Proteins/*isolation & purification ; Nucleosomes/*metabolism ; Tretinoin/pharmacology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 98
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    Estrogen-dependent Leydig cell protein recognized by monoclonal antibody to MCF-7 cell line (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-26
    Description: A protein (27,000 molecular weight) was previously found in rat Leydig cells after treatment with estradiol (E2) and human chorionic gonadotropin (hCG) in vitro. The effect of hCG occurred through increased E2 production. This hormone-regulated rat testicular protein was compared to an estrogen-regulated protein of similar physical characteristics isolated from a human mammary cancer cell line (MCF-7) and present in normal human estrogen target organs. The Leydig cells from rat and human tissue showed specific immunofluorescence and immunoperoxidase staining in the cytoplasm upon incubation with a monoclonal antibody (C11) to the estrogen-regulated protein from MCF-7 cells. Leydig cells after exposure to E2 or hCG showed the highest fluorescence intensity; this intensity was reduced by treatment with Tamoxifen. No reaction was associated with other testicular cells. The estrogen-regulated protein from human cell lines is therefore immunologically similar to that from the rat Leydig cell. The monoclonal antibody should be useful for further characterization of the Leydig cell protein.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ciocca, D R -- Dufau, M L -- CA 11378/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Oct 26;226(4673):445-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6387908" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; *Antibodies, Monoclonal ; Breast Neoplasms/metabolism ; Cell Line ; Chorionic Gonadotropin/pharmacology ; Cross Reactions ; Estradiol/pharmacology ; Fluorescent Antibody Technique ; Humans ; Immunoenzyme Techniques ; Leydig Cells/*analysis ; Male ; Middle Aged ; Proteins/*analysis ; Rats
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 99
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    Mo cell case has its first court hearing (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):813-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494909" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; California ; Cell Line ; *Human Body ; Humans ; *Jurisprudence ; Patents as Topic/legislation & jurisprudence ; *Patient Rights ; Spleen/cytology ; *Tissue and Organ Procurement ; Regents of the University of California on the grounds that two researchers at ; the Los Angeles campus took unfair advantage of him by misappropriating cells ; derived from his spleen in the course of leukemia therapy--cells that were then ; used in research that led to a patent. A federal court procedural hearing on 29 ; October 1984 yielded a ruling that the case will be heard in California state ; court, though it will probably be at least three years before a trial date can be ; scheduled. University officials and scientists see the case as an "outrageous" ; and legally unjustified attempt to assert a claim to the patent. Nevertheless, ; policy makers and university institutional review boards now face the question of ; whether, and how, consent forms should be rewritten to clarify the issue.
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 100
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    VA study of twins may be canceled (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):521.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6387909" target="_blank"〉PubMed〈/a〉
    Keywords: 2,4,5-Trichlorophenoxyacetic Acid/adverse effects ; 2,4-Dichlorophenoxyacetic Acid/adverse effects ; Combat Disorders/psychology ; Female ; Humans ; Pregnancy ; Tetrachlorodibenzodioxin/adverse effects ; *Twins/psychology ; United States ; *United States Department of Veterans Affairs ; *Veterans ; Vietnam
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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