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  • 1
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    Alternative HIV vaccine strategies (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-08-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lehner, Thomas -- Shearer, Gene M -- New York, N.Y. -- Science. 2002 Aug 23;297(5585):1276-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12194176" target="_blank"〉PubMed〈/a〉
    Keywords: AIDS Vaccines/*immunology ; Acquired Immunodeficiency Syndrome/immunology/prevention & control ; Animals ; Chemokines/biosynthesis ; HIV/immunology ; HLA Antigens/immunology ; Humans ; Immunity, Innate ; Isoantigens/immunology ; Macaca ; Receptors, CCR5/*immunology ; SAIDS Vaccines/*immunology ; Simian Acquired Immunodeficiency Syndrome/immunology/prevention & control ; Simian Immunodeficiency Virus/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    UV light exposure and HIV replication (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-11-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Clerici, M -- Shearer, G M -- New York, N.Y. -- Science. 1992 Nov 13;258(5085):1070-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1439812" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*immunology/microbiology ; HIV/*physiology ; Humans ; T-Lymphocytes, Helper-Inducer/immunology ; *Ultraviolet Rays ; Virus Replication/*radiation effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Atopic disease and immunologic response (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-04-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shearer, G M -- Chougnet, C -- Shearer, M S -- New York, N.Y. -- Science. 1997 Apr 4;276(5309):17-8; author reply 18-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9122696" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigen-Presenting Cells/*immunology ; Asthma/etiology/immunology ; BCG Vaccine/*immunology ; Child ; Humans ; Hypersensitivity, Immediate/*immunology ; Infant ; Infant, Newborn ; Mice ; Th1 Cells/*immunology ; Th2 Cells/*immunology ; Vaccination
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    A strategy for prophylactic vaccination against HIV (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1993-05-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Salk, J -- Bretscher, P A -- Salk, P L -- Clerici, M -- Shearer, G M -- New York, N.Y. -- Science. 1993 May 28;260(5112):1270-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Salk Institute for Biological Studies, San Diego, CA 92138.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8098553" target="_blank"〉PubMed〈/a〉
    Keywords: *AIDS Vaccines ; Acquired Immunodeficiency Syndrome/immunology/*prevention & control ; Adjuvants, Immunologic ; Animals ; CD4-Positive T-Lymphocytes/immunology ; Cytokines/immunology ; HIV Antibodies/biosynthesis ; HIV Antigens/immunology ; HIV Infections/immunology/*prevention & control ; Haplorhini ; Humans ; Immunity, Cellular ; Immunologic Memory ; Mice ; T-Lymphocytes, Cytotoxic/immunology ; *Vaccination
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Response (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1993-11-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Salk, J -- Bretscher, P A -- Salk, P L -- Clerici, M -- Shearer, G M -- New York, N.Y. -- Science. 1993 Nov 12;262(5136):1075-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17782052" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Attenuated retrovirus vaccines and AIDS (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-11-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shearer, G M -- Lucey, D R -- Clerici, M -- New York, N.Y. -- Science. 1995 Nov 17;270(5239):1219; author reply 1220-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7502053" target="_blank"〉PubMed〈/a〉
    Keywords: *AIDS Vaccines/adverse effects ; Animals ; Animals, Newborn/*immunology ; Antigen-Presenting Cells/immunology ; Macaca mulatta ; Nervous System/virology ; Simian Acquired Immunodeficiency Syndrome/immunology/*virology ; Simian Immunodeficiency Virus/immunology/*pathogenicity ; Vaccines, Attenuated/adverse effects ; Virulence ; Virus Replication
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Rethinking AIDS and cancer (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-10-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shearer, G M -- Clerici, M -- New York, N.Y. -- Science. 1996 Oct 11;274(5285):163-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8927973" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/drug therapy/*therapy ; Antineoplastic Agents/therapeutic use ; Antiviral Agents/therapeutic use ; Combined Modality Therapy ; Drug Therapy, Combination ; Humans ; *Immunotherapy ; Neoplasms/drug therapy/*therapy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Alloimmunization as an AIDS vaccine? (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1993-10-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shearer, G M -- Clerici, M -- Dalgleish, A -- New York, N.Y. -- Science. 1993 Oct 8;262(5131):161-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8211133" target="_blank"〉PubMed〈/a〉
    Keywords: *AIDS Vaccines ; Animals ; HIV Envelope Protein gp120/immunology ; HIV-1/immunology ; HLA Antigens/*immunology ; Humans ; *Immunization ; Isoantigens/*immunology ; Macaca
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1993-12-10
    Description: Peripheral blood mononuclear cells (PBMCs) from many asymptomatic individuals infected with human immunodeficiency virus-type 1 (HIV) are unresponsive as measured by in vitro T cell proliferation and interleukin-2 (IL-2) production to influenza virus and synthetic peptides of HIV envelope (Env). Strong influenza virus- and Env-stimulated IL-2 responses and T cell proliferation were restored when cultures were stimulated in the presence of IL-12. Interferon-gamma production by PBMCs from HIV seropositive (HIV+) patients was also restored with IL-12. Furthermore, in vitro antigen-specific production of IL-2 and proliferation of PBMCs from HIV- donors were suppressed by antibody to IL-12, but were not enhanced by addition of exogenous IL-12. Thus, IL-12 may be limiting in PBMCs from HIV+ but not HIV- individuals. These findings demonstrate that IL-12 can restore HIV-specific cell-mediated immunity in vitro in HIV-infected individuals and suggest a potential use of IL-12 in augmenting the diminished immunologic functions associated with HIV infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Clerici, M -- Lucey, D R -- Berzofsky, J A -- Pinto, L A -- Wynn, T A -- Blatt, S P -- Dolan, M J -- Hendrix, C W -- Wolf, S F -- Shearer, G M -- New York, N.Y. -- Science. 1993 Dec 10;262(5140):1721-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Experimental Immunology Branch, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7903123" target="_blank"〉PubMed〈/a〉
    Keywords: Cells, Cultured ; Gene Products, env/immunology ; HIV Infections/*immunology ; HIV-1/*immunology ; Humans ; Immunity, Cellular ; Influenza A virus/immunology ; Interferon-gamma/biosynthesis ; Interleukin-12 ; Interleukin-2/biosynthesis/pharmacology ; Interleukins/immunology/*pharmacology ; Killer Cells, Natural/immunology ; Leukocytes, Mononuclear/immunology ; Lymphocyte Activation ; Phytohemagglutinins/immunology ; Recombinant Proteins/pharmacology ; T-Lymphocytes, Helper-Inducer/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-04
    Description: Peripheral blood lymphocytes from patients with the acquired immunodeficiency syndrome (AIDS) or with signs or symptoms that frequently precede AIDS (pre-AIDS) were grown in vitro with added T-cell growth factor and assayed for the expression and release of human T-lymphotropic retroviruses (HTLV). Retroviruses belonging to the HTLV family and collectively designated HTLV-III were isolated from a total of 48 subjects including 18 of 21 patients wih pre-AIDS, three of four clinically normal mothers of juveniles with AIDS, 26 of 72 adult and juvenile patients with AIDS, and from one of 22 normal male homosexual subjects. No HTLV-III was detected in or isolated from 115 normal heterosexual subjects. The number of HTLV-III isolates reported here underestimates the true prevalence of the virus since many specimens were received in unsatisfactory condition. Other data show that serum samples from a high proportion of AIDS patients contain antibodies to HTLV-III. That these new isolates are members of the HTLV family but differ from the previous isolates known as HTLV-I and HTLV-II is indicated by their morphological, biological, and immunological characteristics. These results and those reported elsewhere in this issue suggest that HTLV-III may be the primary cause of AIDS.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallo, R C -- Salahuddin, S Z -- Popovic, M -- Shearer, G M -- Kaplan, M -- Haynes, B F -- Palker, T J -- Redfield, R -- Oleske, J -- Safai, B -- New York, N.Y. -- Science. 1984 May 4;224(4648):500-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6200936" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/blood/*microbiology ; Adult ; Antigens, Viral/analysis ; Cells, Cultured ; Cytopathogenic Effect, Viral ; Deltaretrovirus/*isolation & purification/physiology/ultrastructure ; Female ; Homosexuality ; Humans ; Immune Sera/pharmacology ; Interferon Type I/immunology ; Male ; RNA-Directed DNA Polymerase/metabolism ; Risk ; T-Lymphocytes/microbiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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