Abstract
Phencyclidine elicits hyperthermia at low doses and hypothermia at high doses in rats. Naloxone antagonizes both effects. Phencyclidine's effects on thermo-regulation are probably mediated by an interaction with a mu opiate receptor.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Body Temperature Regulation / drug effects*
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Dose-Response Relationship, Drug
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Female
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Naloxone / pharmacology
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Phencyclidine / antagonists & inhibitors
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Phencyclidine / pharmacology*
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Rats
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Receptors, Opioid / drug effects*
Substances
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Receptors, Opioid
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Naloxone
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Phencyclidine