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  • 1
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-07-19
    Description: Small RNAs, including microRNAs (miRNAs) and short interfering RNAs (siRNAs), are key components of an evolutionarily conserved system of RNA-based gene regulation in eukaryotes. They are involved in many molecular interactions, including defense against viruses and regulation of gene expression during development. miRNAs interfere with expression of messenger RNAs encoding factors that control developmental timing, stem cell maintenance, and other developmental and physiological processes in plants and animals. miRNAs are negative regulators that function as specificity determinants, or guides, within complexes that inhibit protein synthesis (animals) or promote degradation (plants) of mRNA targets.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carrington, James C -- Ambros, Victor -- AI43288/AI/NIAID NIH HHS/ -- GM34028/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2003 Jul 18;301(5631):336-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Gene Research and Biotechnology, and Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR 97331, USA. carrington@orst.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12869753" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Caenorhabditis elegans/genetics/*growth & development ; Drosophila/genetics/*growth & development ; *Gene Expression Regulation, Developmental ; *Gene Expression Regulation, Plant ; Gene Silencing ; MicroRNAs/*metabolism ; *Plant Development ; Plants/genetics/metabolism ; RNA, Plant
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-10-27
    Description: The lin-4 and let-7 antisense RNAs are temporal regulators that control the timing of developmental events in Caenorhabditis elegans by inhibiting translation of target mRNAs. let-7 RNA is conserved among bilaterian animals, suggesting that this class of small RNAs [microRNAs (miRNAs)] is evolutionarily ancient. Using bioinformatics and cDNA cloning, we found 15 new miRNA genes in C. elegans. Several of these genes express small transcripts that vary in abundance during C. elegans larval development, and three of them have apparent homologs in mammals and/or insects. Small noncoding RNAs of the miRNA class appear to be numerous and diverse.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, R C -- Ambros, V -- R01 GM-34028/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2001 Oct 26;294(5543):862-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11679672" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Blotting, Northern ; Caenorhabditis elegans/*genetics/growth & development ; Cloning, Molecular ; Computational Biology ; Conserved Sequence ; DNA, Intergenic ; Gene Expression Regulation ; Gene Expression Regulation, Developmental ; Gene Library ; Genes, Helminth ; Humans ; Nucleic Acid Conformation ; Organ Specificity ; RNA Precursors/genetics/metabolism ; RNA, Antisense/chemistry/genetics/metabolism ; RNA, Helminth/chemistry/*genetics/metabolism ; RNA, Untranslated/chemistry/*genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-08-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ambros, V -- New York, N.Y. -- Science. 2001 Aug 3;293(5531):811-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA. vambros@dartmouth.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11486075" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Caenorhabditis elegans/embryology/genetics ; Endoribonucleases/*metabolism ; Evolution, Molecular ; *Gene Expression Regulation, Developmental ; *Gene Silencing ; RNA/genetics/*metabolism ; RNA Precursors/metabolism ; RNA Processing, Post-Transcriptional ; RNA, Antisense/genetics/metabolism ; RNA, Double-Stranded/*genetics/*metabolism ; RNA, Helminth/genetics/metabolism ; Ribonuclease III
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-11-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Karp, Xantha -- Ambros, Victor -- New York, N.Y. -- Science. 2005 Nov 25;310(5752):1288-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA. xantha.e.karp@dartmouth.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16311325" target="_blank"〉PubMed〈/a〉
    Keywords: 3' Untranslated Regions ; Animals ; Caenorhabditis elegans/*cytology/genetics/growth & development/metabolism ; Caenorhabditis elegans Proteins/*genetics/*metabolism ; Feedback, Physiological ; Female ; Gene Expression Regulation, Developmental ; Membrane Proteins/genetics/*metabolism ; MicroRNAs/*genetics/*metabolism ; Models, Biological ; Proto-Oncogene Proteins c-vav/*genetics/metabolism ; Receptors, Notch ; Regulatory Sequences, Nucleic Acid ; *Signal Transduction ; Stem Cells/*cytology/metabolism ; Transcription, Genetic ; Vulva/cytology/growth & development
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 2013-04-20
    Description: Like mammalian neurons, Caenorhabditis elegans neurons lose axon regeneration ability as they age, but it is not known why. Here, we report that let-7 contributes to a developmental decline in anterior ventral microtubule (AVM) axon regeneration. In older AVM axons, let-7 inhibits regeneration by down-regulating LIN-41, an important AVM axon regeneration-promoting factor. Whereas let-7 inhibits lin-41 expression in older neurons through the lin-41 3' untranslated region, lin-41 inhibits let-7 expression in younger neurons through Argonaute ALG-1. This reciprocal inhibition ensures that axon regeneration is inhibited only in older neurons. These findings show that a let-7-lin-41 regulatory circuit, which was previously shown to control timing of events in mitotic stem cell lineages, is reutilized in postmitotic neurons to control postdifferentiation events.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074024/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074024/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zou, Yan -- Chiu, Hui -- Zinovyeva, Anna -- Ambros, Victor -- Chuang, Chiou-Fen -- Chang, Chieh -- R01 GM034028-25/GM/NIGMS NIH HHS/ -- R01 GM098026/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2013 Apr 19;340(6130):372-6. doi: 10.1126/science.1231321.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Developmental Biology, Cincinnati Children's Hospital Research Foundation, Cincinnati, OH 45229, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23599497" target="_blank"〉PubMed〈/a〉
    Keywords: Aging/physiology ; Animals ; Axons/*physiology ; Caenorhabditis elegans/cytology/*growth & development/physiology ; Caenorhabditis elegans Proteins/genetics/*metabolism ; MicroRNAs/genetics/*metabolism ; Microtubules/physiology ; Nerve Regeneration/genetics/*physiology ; Neurogenesis ; Neurons/cytology/*physiology ; RNA-Binding Proteins/genetics/metabolism ; Transcription Factors/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-10-26
    Description: Mutations in the Caenorhabditis elegans genes lin-14, lin-28, and lin-29 cause heterochronic developmental defects: the timing of specific developmental events in several tissues is altered relative to the timing of events in other tissues. These defects result from temporal transformations in the fates of specific cells, that is, certain cells express fates normally expressed by cells generated at other developmental stages. The identification and characterization of genes that can be mutated to cause heterochrony support the proposal that heterochrony is a mechanism for phylogenetic change and suggest cellular and genetic bases for heterochronic variation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ambros, V -- Horvitz, H R -- GM24663/GM/NIGMS NIH HHS/ -- GM24943/GM/NIGMS NIH HHS/ -- HD00369/HD/NICHD NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 Oct 26;226(4673):409-16.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494891" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Caenorhabditis/*genetics ; Female ; *Genes ; Genetic Variation ; Male ; *Mutation ; *Phylogeny ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Trends in Genetics 10 (1994), S. 123-127 
    ISSN: 0168-9525
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Russian physics journal 15 (1972), S. 1368-1369 
    ISSN: 1573-9228
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Russian physics journal 15 (1972), S. 1298-1301 
    ISSN: 1573-9228
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The excitation and radiation spectra ofΒ-Ga2As3 crystals have been studied. The radiation spectrum consists of two overlapping bands (1.44 and 1.61 eV) and a very weak band in the 2.8–2.9 eV region. The temperature dependence of the halfwidth of the luminescence bands was studied and the position of the levels responsible for the luminescence were determined: E1,v = 0.84 eV and E2,v = 0.59 eV. These luminescence bands in Β-Ga2As3 crystals undergo thermal quenching. The kinetics of the photoconductivity and the photoluminescence were studied and it was shown that the recombination of nonequilibrium carriers occurs by two channels: via fast s levels and slow r levels, the trapping cross section of the latter being $$S_{r_2 } = 3 \cdot 10^{ - 13} cm^2$$ .
    Type of Medium: Electronic Resource
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  • 10
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