Prenatal and neonatal exposure to cimetidine results in gonadal and sexual dysfunction in adult males

Science. 1982 Oct 29;218(4571):493-4. doi: 10.1126/science.7123252.

Abstract

Exposure of rats to cimetidine during intrauterine life and the immediate neonatal period results in hypoandrogenization in adult life with decreased weights of androgen-dependent tissues and decreased concentrations of testosterone. Moreover, sexual behavior patterns in adult life are disturbed as shown by a lack of sexual motivation and decreased performance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abnormalities, Drug-Induced / etiology*
  • Animals
  • Animals, Suckling
  • Cimetidine / metabolism
  • Cimetidine / toxicity*
  • Female
  • Guanidines / toxicity*
  • Male
  • Pregnancy
  • Pregnancy, Animal / drug effects
  • Rats
  • Sex Differentiation / drug effects*
  • Sexual Behavior, Animal / drug effects

Substances

  • Guanidines
  • Cimetidine