Abstract
Rhodamine-123, a cationic laser dye, markedly reduced the clonal growth of carcinoma cells but had little effect on nontumorigenic epithelial cells in vitro. This selective inhibitory effect of Rhodamine-123 on some carcinomas is unusual since known anticancer drugs, such as arabinosyl cytosine and methotrexate, have not been shown to exhibit such selectivity in vitro.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Carcinoma / drug therapy*
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Cell Line
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Cell Survival / drug effects
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Mice
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Mitochondria / metabolism
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Neoplasms, Experimental / drug therapy
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Rhodamine 123
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Rhodamines / metabolism
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Rhodamines / therapeutic use
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Time Factors
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Urinary Bladder Neoplasms / drug therapy