Publication Date:
1984-03-09
Description:
Soil environmentally contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was given by gavage to guinea pigs and rats. The development of a characteristic clinicopathologic syndrome in guinea pigs, the induction of aryl hydrocarbon hydroxylase in rats, and the presence of TCDD in the livers of both species show that TCDD in soil exhibits high biological availability after ingestion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McConnell, E E -- Lucier, G W -- Rumbaugh, R C -- Albro, P W -- Harvan, D J -- Hass, J R -- Harris, M W -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1077-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695194" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Aryl Hydrocarbon Hydroxylases/biosynthesis
;
Biological Availability
;
Body Weight/drug effects
;
Cytochrome P-450 Enzyme System/metabolism
;
Dioxins/*metabolism
;
Eating
;
Enzyme Induction
;
Female
;
Guinea Pigs
;
Intestinal Absorption
;
Liver/drug effects
;
Male
;
Microsomes, Liver/enzymology
;
Organ Size/drug effects
;
Rats
;
Rats, Inbred Strains
;
*Soil Pollutants/toxicity
;
Tetrachlorodibenzodioxin/*metabolism/toxicity
;
Thymus Gland/drug effects
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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