Publication Date:
1994-07-22
Description:
Two molecular mechanisms of T cell-mediated cytotoxicity, one perforin-based, the other Fas-based, have been demonstrated. To determine the extent of their contribution to T cell-mediated cytotoxicity, a range of effector cells from normal control or perforin-deficient mice were tested against a panel of target cells with various levels of Fas expression. All cytotoxicity observed was due to either of these mechanisms, and no third mechanism was detected. Thus, the perforin- and Fas-based mechanisms may account for all T cell-mediated cytotoxicity in short-term in vitro assays.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kagi, D -- Vignaux, F -- Ledermann, B -- Burki, K -- Depraetere, V -- Nagata, S -- Hengartner, H -- Golstein, P -- New York, N.Y. -- Science. 1994 Jul 22;265(5171):528-30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, University of Zurich, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7518614" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Antigens, CD95
;
Antigens, Surface/*immunology
;
Cells, Cultured
;
Concanavalin A/pharmacology
;
*Cytotoxicity, Immunologic
;
Ionomycin/pharmacology
;
Leukemia L1210
;
Lymphocyte Culture Test, Mixed
;
Lymphocytic choriomeningitis virus/immunology
;
Membrane Glycoproteins/*immunology
;
Mice
;
Mice, Inbred BALB C
;
Mice, Inbred C3H
;
Mice, Inbred C57BL
;
Mice, Mutant Strains
;
Molecular Sequence Data
;
Perforin
;
Pore Forming Cytotoxic Proteins
;
T-Lymphocytes, Cytotoxic/*immunology
;
Tetradecanoylphorbol Acetate/pharmacology
;
Tumor Cells, Cultured
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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