Abstract
The interleukin-2 (IL-2) receptor gamma chain (IL-2R gamma) is an essential component of high- and intermediate-affinity IL-2 receptors. IL-2R gamma was demonstrated to be a component of the IL-4 receptor on the basis of chemical cross-linking data, the ability of IL-2R gamma to augment IL-4 binding affinity, and the requirement for IL-2R gamma in IL-4-mediated phosphorylation of insulin receptor substrate-1. The observation that IL-2R gamma is a functional component of the IL-4 receptor, together with the finding that IL-2R gamma associates with the IL-7 receptor, begins to elucidate why deficiency of this common gamma chain (gamma c) has a profound effect on lymphoid function and development, as seen in X-linked severe combined immunodeficiency.
MeSH terms
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Animals
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Base Sequence
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Cell Line
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Cell Line, Transformed
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Genetic Linkage
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Humans
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Insulin Receptor Substrate Proteins
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Interleukin-4 / metabolism
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L Cells
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Mice
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Molecular Sequence Data
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Phosphoproteins / metabolism
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Phosphorylation
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Receptors, Interleukin-2 / chemistry
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Receptors, Interleukin-2 / genetics
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Receptors, Interleukin-2 / metabolism*
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Receptors, Interleukin-4
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Receptors, Mitogen / chemistry
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Receptors, Mitogen / genetics
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Receptors, Mitogen / metabolism*
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Severe Combined Immunodeficiency / genetics
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Severe Combined Immunodeficiency / immunology
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Signal Transduction
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Transfection
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X Chromosome
Substances
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IRS1 protein, human
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Insulin Receptor Substrate Proteins
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Irs1 protein, mouse
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Phosphoproteins
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Receptors, Interleukin-2
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Receptors, Interleukin-4
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Receptors, Mitogen
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Interleukin-4