Publication Date:
1992-07-17
Description:
A third subunit, the gamma chain, of the human interleukin-2 receptor (IL-2R) was identified, and a complementary DNA clone encoding this member of the cytokine receptor family was isolated. The gamma chain is necessary for the formation of the high- and intermediate-affinity receptors, which consists of alpha beta gamma heterotrimers and beta gamma heterodimers, respectively. The IL-2R on murine fibroblastoid cells can be internalized after binding IL-2 only if the gamma chain is present; alpha and beta are insufficient for internalization. Thus, the gamma chain is an indispensable component of the functional IL-2R.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Takeshita, T -- Asao, H -- Ohtani, K -- Ishii, N -- Kumaki, S -- Tanaka, N -- Munakata, H -- Nakamura, M -- Sugamura, K -- New York, N.Y. -- Science. 1992 Jul 17;257(5068):379-82.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1631559" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Blotting, Northern
;
Chromosome Mapping
;
Cloning, Molecular
;
Humans
;
Interleukin-2/metabolism
;
Molecular Sequence Data
;
RNA, Messenger/biosynthesis
;
Receptors, Interleukin-2/*genetics/isolation & purification/physiology
;
Sequence Homology, Nucleic Acid
;
Transcription, Genetic
;
Transfection
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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