Publication Date:
1994-04-08
Description:
An amino-terminal transactivation domain is required for Myc to function as a transcription factor controlling cell proliferation, differentiation, and apoptosis. A complementary DNA expression library was screened with a Myc fusion protein to identify proteins interacting with this domain, and a clone encoding the Rb-related p107 protein was isolated. The p107 protein was shown to associate with Myc in vivo and to suppress the activity of the Myc transactivation domain. However, mutant forms of Myc from Burkitt lymphoma cells, which contain sequence alterations in the transactivation domain, were resistant to p107-mediated suppression. Thus, disruption of a regulatory interaction between Myc and p107 may be important in tumorigenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gu, W -- Bhatia, K -- Magrath, I T -- Dang, C V -- Dalla-Favera, R -- CA 37165/CA/NCI NIH HHS/ -- CA 51497/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1994 Apr 8;264(5156):251-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8146655" target="_blank"〉PubMed〈/a〉
Keywords:
3T3 Cells
;
Animals
;
Base Sequence
;
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
;
Basic-Leucine Zipper Transcription Factors
;
DNA-Binding Proteins/metabolism
;
Helix-Loop-Helix Motifs
;
Lymphoma, B-Cell
;
Mice
;
Molecular Sequence Data
;
*Nuclear Proteins
;
Point Mutation
;
Proteins/*metabolism
;
Proto-Oncogene Proteins c-myc/genetics/*metabolism
;
Recombinant Fusion Proteins/metabolism
;
Retinoblastoma-Like Protein p107
;
*Suppression, Genetic
;
*Transcription Factors
;
*Transcriptional Activation
;
Transfection
;
Tumor Cells, Cultured
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
