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  • 1
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    Imaging elementary events of calcium release in skeletal muscle cells (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-09-22
    Description: In skeletal muscle cells, calcium release to trigger contraction occurs at triads, specialized junctions where sarcoplasmic reticulum channels are opened by voltage sensors in the transverse tubule. Scanning confocal microscopy was used in cells under voltage clamp to measure the concentration of intracellular calcium, [Ca2+]i, at individual triads and [Ca2+]i gradients that were proportional to calcium release. In cells stimulated with small depolarizations, the [Ca2+]i gradients broke down into elementary events, corresponding to single-channel currents of about 0.1 picoampere. Because these events were one-tenth to one-fifth the size of calcium sparks (elementary release events of cardiac muscle), skeletal muscle control mechanisms appear to be fundamentally different.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tsugorka, A -- Rios, E -- Blatter, L A -- New York, N.Y. -- Science. 1995 Sep 22;269(5231):1723-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biophysics and Physiology, Rush University, Chicago, IL 60612, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7569901" target="_blank"〉PubMed〈/a〉
    Keywords: Aniline Compounds/metabolism ; Animals ; Calcium/*metabolism ; Calcium Channels/*metabolism ; Electric Stimulation ; Fluorescent Dyes/metabolism ; Microscopy, Confocal ; Muscle Fibers, Skeletal/*metabolism ; Muscle, Skeletal/cytology/*metabolism ; Patch-Clamp Techniques ; Rana pipiens ; Sarcoplasmic Reticulum/metabolism ; Xanthenes/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Visualization of quantal synaptic transmission by dendritic calcium imaging (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-01-28
    Description: As changes in synaptic strength are thought to be critical for learning and memory, it would be useful to monitor the activity of individual identified synapses on mammalian central neurons. Calcium imaging of cortical neurons grown in primary culture was used to visualize the activation of individual postsynaptic elements by miniature excitatory synaptic currents elicited by spontaneous quantal release. This approach revealed that the probability of spontaneous activity differed among synapses on the same dendrite. Furthermore, synapses that undergo changes in activity induced by glutamate or phorbol ester treatment were identified.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murphy, T H -- Baraban, J M -- Wier, W G -- Blatter, L A -- New York, N.Y. -- Science. 1994 Jan 28;263(5146):529-32.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7904774" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/*metabolism ; Cells, Cultured ; Cerebral Cortex ; Dendrites/*metabolism ; Glutamates/pharmacology ; Glutamic Acid ; Kinetics ; Microelectrodes ; Neuronal Plasticity ; Neurons/*physiology ; Phorbol Esters/pharmacology ; Rats ; Receptors, N-Methyl-D-Aspartate/physiology ; Synapses/*physiology ; *Synaptic Transmission ; Tetrodotoxin/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
    Electronic Resource
    Electronic Resource
    Sodium/calcium exchange in ventricular muscle (1987)
    Springer
    Cellular and molecular life sciences 43 (1987), S. 1140-1145 
    Details
    ISSN: 1420-9071
    Keywords: Ferret heart ; Na/Ca exchange ; Ca buffering ; Ca homeostasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Ventricular cells possess two Ca extrusion mechanisms, a Na/Ca exchange system and a Ca pump. Reversing the exchanger by extracellular Na removal causes [Na]i to decrease, and the cells take up mmolar quantities of calcium. Since [Ca]i shows only a marginal increase the calcium load must be buffered. The capacity of the SR is limited so the mitochondria probably buffer a large part of this load. However, when Ca uptake into the mitochondria is blocked, the gain in Ca is still mmolar and the increase in [Ca]i still marginal, suggesting an additional buffering site. Measurements of the Na/Ca stoichiometry on sarcolemmal vesicles gave a value of 3, but in ventricle values of around 2.5 or 3 are found. Reasons for this are discussed, as are the differences amongst the different methods of Ca measurement. The interaction of the sarcolemmal Ca pump and the exchanger are considered and it is suggested they could interact via [Na]i, At rest both systems could remove Ca from the cell but on a large perturbation the Na/Ca exchange would be the more important of the two.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01945512
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    Paper (German National Licenses)
    Fulltext
  • 4
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    Sarcoplasmic reticulum Ca2+ release flux underlying Ca2+ sparks in cardiac muscle (1997)
    National Academy of Sciences
    Details
    Publication Date: 1997-04-15
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 5
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    Sodium/calcium exchange in ventricular muscle (1987)
    Springer
    Details
    Publication Date: 1987-12-01
    Print ISSN: 0014-4754
    Topics: Biology , Medicine
    Published by Springer
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