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  • Humans  (655)
  • 03. Hydrosphere::03.04. Chemical and biological::03.04.06. Hydrothermal systems
  • 04. Solid Earth::04.04. Geology::04.04.08. Sediments: dating, processes, transport
  • 04. Solid Earth::04.04. Geology::04.04.10. Stratigraphy
  • 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
  • Acoustics
  • Binding Sites
  • Data analysis / ~ processing
  • Fluids
  • Schussler
  • Textbook of geophysics
  • American Association for the Advancement of Science (AAAS)  (677)
  • Elsevier  (9)
  • Springer  (3)
  • Cambridge U. Press
  • Cambridge Univ. Press
  • Soc. of Exploration Geophys.
  • W.H. Freeman
  • 2020-2023
  • 2010-2014  (689)
  • 2000-2004
  • 1980-1984
  • 2011  (689)
Collection
Keywords
Publisher
Years
  • 2020-2023
  • 2010-2014  (689)
  • 2000-2004
  • 1980-1984
Year
  • 1
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    Tracing thermal aquifers of El Chichón volcano-hydrothermal system (México) with 87Sr/86Sr, Ca/Sr and REE (2011)
    Elsevier
    Details
    Publication Date: 2020-11-26
    Description: The volcano–hydrothermal system of El Chichón volcano, Chiapas, Mexico, is characterized by numerous thermal manifestations including an acid lake, steam vents and boiling springs in the crater and acid and neutral hot springs and steaming ground on the flanks. Previous research on major element chemistry reveals that thermal waters of El Chichón can be divided in two groups: (1) neutral waters discharging in the crater and southern slopes of the volcano with chloride content ranging from 1500 to 2200 mg/l and (2) acid-toneutral waters with Cl up to 12,000 mg/l discharging at the western slopes. Our work supports the concept that each group of waters is derived from a separate aquifer (Aq. 1 and Aq. 2). In this study we apply Sr isotopes, Ca/Sr ratios and REE abundances along with the major and trace element water chemistry in order to discriminate and characterize these two aquifers. Waters derived from Aq. 1 are characterized by 87Sr/86Sr ratios ranging from 0.70407 to 0.70419, while Sr concentrations range from 0.1 to 4 mg/l and Ca/Sr weight ratios from 90 to 180, close to average values for the erupted rocks. Waters derived from Aq. 2 have 87Sr/86Sr between 0.70531 and 0.70542, high Sr concentrations up to 80 mg/l, and Ca/Sr ratio of 17–28. Aquifer 1 is most probably shallow, composed of volcanic rocks and situated beneath the crater, within the volcano edifice. Aquifer 2 may be situated at greater depth in sedimentary rocks and by some way connected to the regional oil-gas field brines. The relative water output (l/s) from both aquifers can be estimated as Aq. 1/Aq. 2– 30. Both aquifers are not distinguishable by their REE patterns. The total concentration of REE, however, strongly depends on the acidity. All neutral waters including high-salinity waters from Aq. 2 have very low total REE concentrations (b0.6 μg/l) and are characterized by a depletion in LREE relative to El Chichón volcanic rock, while acid waters from the crater lake (Aq. 1) and acid AS springs (Aq. 2) have parallel profile with total REE concentration from 9 to 98 μg/l. The highest REE concentration (207 μg/l) is observed in slightly acid shallow cold Ca-SO4 ground waters draining fresh and old pyroclastic deposits rich in magmatic anhydrite. It is suggested that the main mechanism controlling the concentration of REE in waters of El Chichón is the acidity. As low pH results from the shallow oxidation of H2S contained in hydrothermal vapors, REE distribution in thermal waters reflects the dissolution of volcanic rocks close to the surface or lake sediments as is the case for the crater lake.
    Description: -
    Description: Published
    Description: 55-66
    Description: 1.2. TTC - Sorveglianza geochimica delle aree vulcaniche attive
    Description: JCR Journal
    Description: reserved
    Keywords: hydrogeochemistry ; geothermal systems ; Sr isotopes ; REE ; El Chichón Volcano ; 03. Hydrosphere::03.02. Hydrology::03.02.03. Groundwater processes ; 03. Hydrosphere::03.04. Chemical and biological::03.04.03. Chemistry of waters ; 03. Hydrosphere::03.04. Chemical and biological::03.04.05. Gases ; 03. Hydrosphere::03.04. Chemical and biological::03.04.06. Hydrothermal systems ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 04. Solid Earth::04.08. Volcanology::04.08.08. Volcanic risk
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 2
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    Chronology of the Lower-Middle Pleistocene succession of the south-western part of the Crotone Basin (Calabria, Southern Italy) (2011)
    Elsevier
    Details
    Publication Date: 2021-05-17
    Description: Biostratigraphy based on calcareous nannofossils, integrated by magnetostratigraphic, geochronological and isotopic data, allowed establishing a precise chronological framework for the Pleistocene succession within the south-western sector of the Crotone Basin (Calabria, Southern Italy), where the Pliocenee Pleistocene global stratotype section and point is defined, thus demonstrating that sedimentation was quasi-continuous during most of the Lower and Middle Pleistocene. At a large scale, the Pleistocene succession in this sector of the Crotone Basin is characterized by an evident shallowing-upwards trend, showing facies changes from bathyal to shelfal to littoral/continental. However, comparison between adjacent sectors within the investigated area demonstrates that stratigraphic architectures change vastly on very short distances. Our chronological constraints indicate that such changes in sedimentation styles probably occurred in response to differential subsidence rates, which originated tectonically-controlled synsedimentary structures where accommodation space and sediment yield were allotted unevenly. This articulated physiography led to striking differences in the overall thicknesses and organization of Pleistocene stratigraphies and, eventually, to a distinct diachroneity in the first appearance of shallow-marine deposits. In addition, superimposed are complex interplays between regional and local tectonics, eustasy and orbitally-forced climate changes. These interactions have been highlighted by the oxygen isotope stratigraphy established for a part of the studied succession, which is likely to document almost continuously the interval from Marine Isotope Stage (MIS) 26 to MIS 17. In its younger part (post-MIS 17), chronological ties are poor, as the succession is dominated by shallow-water to continental deposits showing a prominent organization into cyclothems. Nevertheless, based on the chronology of the underlying units, it is feasible that basin infill ended during MIS 15-MIS 14 times.
    Description: Published
    Description: 1185-1200
    Description: 2.2. Laboratorio di paleomagnetismo
    Description: JCR Journal
    Description: restricted
    Keywords: Pleistocene ; Chronostratigraphy ; Southern Italy ; 04. Solid Earth::04.04. Geology::04.04.08. Sediments: dating, processes, transport ; 04. Solid Earth::04.05. Geomagnetism::04.05.06. Paleomagnetism
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 3
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    Sedimentary processes on the Wilkes Land continental rise reflect changes in glacial dynamic and bottom water flow (2011)
    Springer
    Details
    Publication Date: 2020-12-15
    Description: Four sediment cores were analysed in order to determine the sedimentary processes associated with the channel-ridge depositional system that characterise the George V Land continental margin on the Wilkes Land. The sedimentary record indicates that the WEGA channel was a dynamic turbiditic system up to M.I.S. 11. After this time, the channel became a lower-energy environment with sediments delivered to the channel through high-density bottom waters that we identify to be the high salinity shelf waters (HSSW) forming on the shelf area. The HSSW entrains the fine-grained sediments of the shelf area and deliver them to the continental rise. The biostratigraphy and facies of the sediments within the WEGA channel indicate that the HSSW down flow was active also during last glacial. The change from a turbiditic system to a lowenergy bottom current system within the WEGA channel likely reflects a different ice-flow pattern, with ice-sheet reaching the continental shelf edge only within the ice trough (ice stream).
    Description: Published
    Description: 909 - 926
    Description: 2.2. Laboratorio di paleomagnetismo
    Description: JCR Journal
    Description: restricted
    Keywords: High salinity shelf water ; Turbidity currents ; Glacio-marine depositional processes ; Marine isotopic stage 11 ; Glacial dynamic changes ; 02. Cryosphere::02.02. Glaciers::02.02.05. Ice dynamics ; 04. Solid Earth::04.04. Geology::04.04.08. Sediments: dating, processes, transport ; 04. Solid Earth::04.05. Geomagnetism::04.05.06. Paleomagnetism
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 4
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    A model for seismicity rates observed during the 1982–1984 unrest at Campi Flegrei caldera (Italy) (2011)
    Elsevier
    Details
    Publication Date: 2017-04-04
    Description: We consider the space–time distribution of seismicity during the 1982–1984 unrest at Campi Flegrei caldera (Italy) where a correlation between seismicity and rate of ground uplift was suggested. In order to investigate this effect, we present a model based on stress transfer from the deformation source responsible for the unrest to potential faults. We compute static stress changes caused by an inflating source in a layered half-space. Stress changes are evaluated on optimally oriented planes for shear failure, assuming a regional stress with horizontal extensional axis trending NNE-SSW. The inflating source is modeled as inferred by previous studies from inversion of geodetic data with the same crustal model here assumed. The magnitude of the regional stress is constrained by imposing an initial condition of “close to failure” to potential faults. The resulting spatial distribution of stress changes is in agreement with observations. We assume that the temporal evolution of ground displacement, observed by a tide-gauge at Pozzuoli, was due mainly to time dependent processes occurring at the inflating source. We approximate this time dependence in piecewise-linear way and we attribute it to each component of average stress-change in the region interested by the observed seismicity. Then we evaluate the effect of a time dependent stressing rate on seismicity, by following the approach indicated by Dieterich (1994) on the basis of the rate- and state-dependent rheology of faults. The seismicity rate history resulting from our model is in general agreement with data during the period 1982– 1984 for reasonable values of unconstrained model-parameters, the initial value of the direct effect of friction and the reference shear stressing rate. In particular, this application shows that a decreasing stressing-rate is effective in damping the seismicity rate.
    Description: Published
    Description: 287-298
    Description: 3.6. Fisica del vulcanismo
    Description: JCR Journal
    Description: reserved
    Keywords: Triggered seismicity ; Volcanic tremor ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 5
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    Societal need for improved understanding of climate change, anthropogenic impacts, and geo-hazard warning drive development of ocean observatories in European Seas (2011)
    Elsevier
    Details
    Publication Date: 2017-04-04
    Description: Society’s needs for a network of in situ ocean observing systems cross many areas of earth and marine science. Here we review the science themes that benefit from data supplied from ocean observatories. Understanding from existing studies is fragmented to the extent that it lacks the coherent long-term monitoring needed to address questions at the scales essential to understand climate change and improve geo-hazard early warning. Data sets from the deep sea are particularly rare with long-term data available from only a few locations worldwide. These science areas have impacts on societal health and well-being and our awareness of ocean function in a shifting climate. Substantial efforts are underway to realise a network of open-ocean observatories around European Seas that will operate over multiple decades. Some systems are already collecting high-resolution data from surface, water column, seafloor, and sub-seafloor sensors linked to shore by satellite or cable connection in real or near-real time, along with samples and other data collected in a delayed mode. We expect that such observatories will contribute to answering major ocean science questions including: How can monitoring of factors such as seismic activity, pore fluid chemistry and pressure, and gas hydrate stability improve seismic, slope failure, and tsunami warning? What aspects of physical oceanography, biogeochemical cycling, and ecosystems will be most sensitive to climatic and anthropogenic change? What are natural versus anthropogenic changes? Most fundamentally, how are marine processes that occur at differing scales related? The development of ocean observatories provides a substantial opportunity for ocean science to evolve in Europe. Here we also describe some basic attributes of network design. Observatory networks provide the means to coordinate and integrate the collection of standardised data capable of bridging measurement scales across a dispersed area in European Seas adding needed certainty to estimates of future oceanic conditions. Observatory data can be analysed along with other data such as those from satellites, drifting floats, autonomous underwater vehicles, model analysis, and the known distribution and abundances of marine fauna in order to address some of the questions posed above. Standardised methods for information management are also becoming established to ensure better accessibility and traceability of these data sets and ultimately to increase their use for societal benefit. The connection of ocean observatory effort into larger frameworks including the Global Earth Observation System of Systems (GEOSS) and the Global Monitoring of Environment and Security (GMES) is integral to its success. It is in a greater integrated framework that the full potential of the component systems will be realised.
    Description: Published
    Description: 1-33
    Description: 3.7. Dinamica del clima e dell'oceano
    Description: JCR Journal
    Description: reserved
    Keywords: Seafloor and water columnobservatories ; 01. Atmosphere::01.01. Atmosphere::01.01.02. Climate ; 01. Atmosphere::01.01. Atmosphere::01.01.04. Processes and Dynamics ; 01. Atmosphere::01.01. Atmosphere::01.01.08. Instruments and techniques ; 03. Hydrosphere::03.01. General::03.01.03. Global climate models ; 03. Hydrosphere::03.01. General::03.01.07. Physical and biogeochemical interactions ; 03. Hydrosphere::03.01. General::03.01.08. Instruments and techniques ; 03. Hydrosphere::03.03. Physical::03.03.01. Air/water/earth interactions ; 03. Hydrosphere::03.03. Physical::03.03.02. General circulation ; 03. Hydrosphere::03.03. Physical::03.03.03. Interannual-to-decadal ocean variability ; 03. Hydrosphere::03.03. Physical::03.03.05. Instruments and techniques ; 03. Hydrosphere::03.04. Chemical and biological::03.04.01. Biogeochemical cycles ; 03. Hydrosphere::03.04. Chemical and biological::03.04.02. Carbon cycling ; 03. Hydrosphere::03.04. Chemical and biological::03.04.03. Chemistry of waters ; 03. Hydrosphere::03.04. Chemical and biological::03.04.04. Ecosystems ; 03. Hydrosphere::03.04. Chemical and biological::03.04.05. Gases ; 03. Hydrosphere::03.04. Chemical and biological::03.04.06. Hydrothermal systems ; 03. Hydrosphere::03.04. Chemical and biological::03.04.08. Instruments and techniques ; 04. Solid Earth::04.01. Earth Interior::04.01.02. Geological and geophysical evidences of deep processes ; 04. Solid Earth::04.04. Geology::04.04.04. Marine geology ; 04. Solid Earth::04.04. Geology::04.04.11. Instruments and techniques ; 04. Solid Earth::04.04. Geology::04.04.12. Fluid Geochemistry ; 04. Solid Earth::04.05. Geomagnetism::04.05.05. Main geomagnetic field ; 04. Solid Earth::04.05. Geomagnetism::04.05.08. Instruments and techniques ; 04. Solid Earth::04.06. Seismology::04.06.06. Surveys, measurements, and monitoring ; 04. Solid Earth::04.06. Seismology::04.06.07. Tomography and anisotropy ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology ; 04. Solid Earth::04.06. Seismology::04.06.10. Instruments and techniques ; 04. Solid Earth::04.07. Tectonophysics::04.07.02. Geodynamics ; 04. Solid Earth::04.07. Tectonophysics::04.07.03. Heat generation and transport ; 04. Solid Earth::04.07. Tectonophysics::04.07.04. Plate boundaries, motion, and tectonics ; 04. Solid Earth::04.07. Tectonophysics::04.07.07. Tectonics ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 04. Solid Earth::04.08. Volcanology::04.08.02. Experimental volcanism ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 04. Solid Earth::04.08. Volcanology::04.08.07. Instruments and techniques ; 05. General::05.01. Computational geophysics::05.01.01. Data processing ; 05. General::05.02. Data dissemination::05.02.99. General or miscellaneous ; 05. General::05.02. Data dissemination::05.02.01. Geochemical data ; 05. General::05.02. Data dissemination::05.02.02. Seismological data ; 05. General::05.02. Data dissemination::05.02.03. Volcanic eruptions ; 05. General::05.02. Data dissemination::05.02.04. Hydrogeological data ; 05. General::05.08. Risk::05.08.01. Environmental risk ; 05. General::05.08. Risk::05.08.02. Hydrogeological risk
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 6
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    Acoustic Emission spectra classification from rock samples of Etna basalt in deformation-decompression laboratory experiments (2011)
    Springer
    Details
    Publication Date: 2020-02-24
    Description: Recent laboratory experiments on Etna basalt have permitted the generation of an extensive catalogue of acoustic emissions (AE) during two key experimental phases. Firstly, AE have been generated during triaxial compressional tests and formation of a complex fracture/damage zone. Secondly, rapid fluid decompression through the damage/shear zone after failure. We report new results from an advanced analysis method using AE spectrograms, allowing us to qualitatively identify high and low frequency events; essentially comparable to seismicity in volcanic areas. Our analysis, for the first time, quantitatively classifies ‘families’ of AE events belonging to the same experimental stage without prior knowledge. We then test the method using the AE catalogue for verification, which is not possible with field data. FFT spectra, obtained from AE, are subdivided into equal log intervals for which a local slope is calculated. Factor analysis has been then applied, in which we use a data matrix of columns representing the variables considered (frequency data averaged in bins) vs. rows indicating each AE data set. Factor analysis shows that the method is very effective and suitable for reducing data complexity, allowing distinct factors to be obtained. We conclude that most of the data variance (information content) can be well represented by three factors only, each one representing a well defined frequency range. Through the factor scores it is possible to represent data in a lower dimension factor space. Classification is then possible by identifying clusters of AE belonging to the same experimental stage. This allows us to propose a deformation/decompression interpretation based solely on the AE frequency analysis and to identify a third type of AE related to fluid movements in the deformation stage.
    Description: Published
    Description: 201-211
    Description: 1.2. TTC - Sorveglianza geochimica delle aree vulcaniche attive
    Description: open
    Keywords: acoustic emissions ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology ; 04. Solid Earth::04.08. Volcanology::04.08.05. Volcanic rocks ; 05. General::05.01. Computational geophysics::05.01.04. Statistical analysis
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: book chapter
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  • 7
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    Source location of long period seismicity at Volcàn de Colima, México (2011)
    Springer
    Details
    Publication Date: 2017-04-04
    Description: This paper presents an analysis of seismicity associated with the volcanic activity of Volcàn de Colima (México) and recorded in the period November 2005–April 2006 during a field survey by the Istituto Nazionale di Geofisica e Vulcanologia (INGV)–Osservatorio Vesuviano, the Observatorio Vulcanologico de Colima of Colima University and the Instituto Andaluz de Geofisica, University of Granada. Three different types of volcanic earthquakes have been identified on the basis of their spectral properties: Type A (0.3–1 Hz), Type B (1–5 Hz) and Type C (3–4 Hz). Results of polarization analysis applied to Type A events show a predominance of radial motion, indicating that the wavefield comprises compressional waves (P) and shear waves polarized in the vertical plane (SV), while the signal always begins with a negative polarity. Type A, B and C earthquakes have been located using both a flat layered model and a 3D model including topography. Hypocentre distributions indicate that the source of Type A signals is very shallow and confined to a small volume lying about 1 km below the crater. In contrast, the source of Type B and C events is significantly deeper, with most hypocentres located in a volume of about 1 km3 centred at 2.5–3 km depth. A cluster analysis based on the crosscorrelation among the waveforms of different events recorded at the same station was applied to Type A earthquakes. Only two clusters, which include only a small percentage of events were found, indicating that earthquake families were uncommon during the period of our survey.
    Description: Published
    Description: 887-898
    Description: 3.1. Fisica dei terremoti
    Description: JCR Journal
    Description: reserved
    Keywords: Colima Volcano ; Long Period Events ; Earthquake location ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 8
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    The magmatic feeding system of the Campi Flegrei caldera: Architecture and temporal evolution (2011)
    Elsevier
    Details
    Publication Date: 2017-04-04
    Description: To develop a model of both the structure and evolution of the Campi Flegrei caldera (CFc) magmatic feeding system, geochronological, geochemical and Sr, Nd, Pb and B isotopic data of representative volcanic products of the past 15 ka have been combined with geophysical and melt inclusion literature data, structural setting and dynamics of the resurgent caldera. According to previous petrological data, the CFc magmatic feeding system consists of a deep reservoir, in which mantle-derived K-basaltic parental magmas differentiate to shoshonite, latite and trachyte, through combined crustal contamination and fractional crystallization processes, and shallowreservoirswhere the evolvedmagmas further differentiate andmingle/mix before eruptions. The Sr,Nd, Pb, and B isotope data allowrecognition of three distinctmagmatic components.One component is believedto be residualmagmafromtheNeapolitanYellowTuff (NYT) caldera forming eruption. The NYT component (87Sr/86Sr of 0.70750–53, 143Nd/144Nd ratio of ca. 0.51246, 206Pb/204Pb of ca. 19.04 and δ11B of ca. –7.9‰), has been the most prevalent component over the past 15 ka being mixed, in most cases, with the other two components. One of these other components is best recognized in the Minopoli 2 magma, first erupted 10 ka ago. Minopoli 2 magma is shoshonitic in composition and is the most enriched in radiogenic Sr (87Sr/86Sr of ca. 0.70860) and unradiogenic Nd and Pb (143Nd/144Nd ratio of ca. 0.51236, 206Pb/204Pb of ca. 18.90), and is characterised by δ11B value of ca. –7.32‰. The third component is trachytic in composition and has higher 206Pb/204Pb (ca. 19.08), lower 87Sr/86Sr (ca. 0.70726) and δ11B (−9.8‰) and higher 143Nd/144Nd (ca. 0.51250), with respect to the NYT component. This third component is best recognized in the Astroni 6 magma and did not appear until ca. 4 ka. The identified isotopically distinct magmatic components were erupted in different sectors of the CFc. During both I (b14.9–9.5 ka) and II (8.6–8.2 ka) epochs of volcanic activity,magmas similar to the NYT component, and those resulting from mixing between Minopoli 2 and NYT components were erupted from vents located mostly on the marginal faults of the NYT caldera. During the III epoch (4.8–3.8 ka) magmas either similar to NYT, or resulting from mixing between Astroni 6 and NYT components were erupted from vents located along faults bordering the La Starza resurgent block and, subordinately, the NYT caldera. Moreover, magmas resulting from mixing betweenMinopoli 2 and NYT components were erupted fromvents located along NE–SW regional faults activated during caldera resurgence. The inferred present structure of the feeding system is characterised by a deep reservoir, whose top is at about 8 kmdepth, that hosts shoshonitic–trachyticmagmas. Remnants of the NYT magma reside at shallower depth in different sectors of the crust underlying CFc, and were sometimes intercepted by volatile-rich magmas of deep provenance during the three epochs of CFc volcanic activity.
    Description: Published
    Description: 227-241
    Description: 2.3. TTC - Laboratori di chimica e fisica delle rocce
    Description: 3.5. Geologia e storia dei vulcani ed evoluzione dei magmi
    Description: JCR Journal
    Description: reserved
    Keywords: Campi Flegrei caldera ; Magmatic system ; Caldera structure ; Geochemistry ; Isotopes ; 04. Solid Earth::04.04. Geology::04.04.07. Rock geochemistry ; 04. Solid Earth::04.04. Geology::04.04.10. Stratigraphy ; 04. Solid Earth::04.08. Volcanology::04.08.05. Volcanic rocks
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 9
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    Insights into explosive activity at closely-spaced eruptive vents using infrasound signals: Example of Mt. Etna 2008 eruption (2011)
    Elsevier
    Details
    Publication Date: 2017-04-04
    Description: On 13 May 2008 an eruptive fissure opened on Mount Etna's eastern flank feeding both explosive activity and lava effusion from multiple vents for about 14 months. During the investigated May-September 2008 eruptive period, infrasound recordings from a 4 station-sparse network allowed tracking of the explosive activity in terms of location and dynamics. In order to focus on activity from the eruptive fissure, the infrasonic events generated by the summit craters were selected by using both spectral features and time delays between pairs of stations and excluded from our analysis. Then, to accurately locate events from the fissure, we used a composite method, based on the semblance and brightness functions. This enabled the study of the co-existence of more than one infrasound source and/or its migration along the eruptive fissure. Hence, results permitted us to discriminate the number of active vents and their location along the fissure even when, due to poor weather conditions, it was not possible to access the vents or carry out direct observations. The eruptive activity was characterised by variations in the number of active vents according to the overall intensity of the eruptive event. Variability of the infrasound waveforms highlighted either that distinct vents produced signals with different waveforms, or that single vents generated different events during distinct periods of time, or finally both the previous phenomena. We applied the strombolian bubble vibration model to model waveform differences and attributed the signal variations to bubble radius changes.
    Description: Published
    Description: 1-11
    Description: 1.4. TTC - Sorveglianza sismologica delle aree vulcaniche attive
    Description: JCR Journal
    Description: reserved
    Keywords: Etna ; Infrasound ; Infrasonic source location ; explosive activity ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 10
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    Spatio-temporal evolution of volcano seismicity: A laboratory study (2011)
    Elsevier
    Details
    Publication Date: 2017-04-04
    Description: We report a laboratory and microstructural study of a suite of deformation experiments in which basalt from Mount Etna volcano is deformed and fractured at an effective confining pressure representative of conditions under a volcanic edifice (40 MPa). Particular attention was paid to the formation of a fracture and damage zone with which to stimulate coupled hydro-mechanical interactions that create the various types of seismicity recorded on volcanic edifices, and which usually precede eruption. Location of AE events through time shows the formation of a fault plane during which waveforms exhibit the typical high frequency characteristics of volcano-tectonic (VT) earthquakes. We found that these VT earthquakes were particularly pronounced when generated using dry samples, compared to samples saturated with a pore fluid (water). VT events generated during deformation of water saturated sample are characterised by a distinctive high frequency onset and a longer, low frequency coda exhibiting properties often seen in the field as hybrid events. We present evidence that hybrid events are, in fact, the common type of volcanic seismic event with either VT or low frequency (LF) events representing end members, and whose proportion depend on pore fluid being present in the rock type being deformed, as well as how close the rock is to failure. We find a notable trend of reducing instances of hybrid events leading up to the failure stage in our experiments, suggesting that during this stage, the pore fluid present in the rock moves sufficiently quickly to provide a resonance, seen as a LF coda. Our data supports recent modeling and field studies that postulate that hybrid events generated in volcanic areas are likely to be generated through the interaction of hydrothermal fluids moving through a combination of pre-existing microcrack networks and larger faults, such as those we observe in forensic (post-test) examination.
    Description: Published
    Description: 315-323
    Description: 2.3. TTC - Laboratori di chimica e fisica delle rocce
    Description: JCR Journal
    Description: reserved
    Keywords: volcano-tectonics, acoustic emission, rock physics, seismology, hazard ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology ; 04. Solid Earth::04.08. Volcanology::04.08.05. Volcanic rocks ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 05. General::05.02. Data dissemination::05.02.02. Seismological data
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 11
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    Short residence times for alkaline Vesuvius magmas in a multi-depth supply system: Evidence from geochemical and textural studies (2011)
    Elsevier
    Details
    Publication Date: 2017-04-04
    Description: It is crucial to understand magma chamber chemico-physical conditions and residence times for high-risk volcanoes because these factors control the occurrence and size of future eruptions. In order to define magmatic pressure–temperature conditions and residence times at the Somma–Vesuvius volcano, we studied the geochemistry and texture of selected past eruptions that are representative of the entire volcanic history. Our petrological model indicates a multi-depth magma chamber composed of a deeper tephritic (350– 400 Mpa) magma layer, which fed Strombolian and effusive eruptions during open-conduit activity, and an upper (200–250 Mpa) phonolitic level, which supplied the high explosive events that followed closedconduit repose time. This upper reservoir matches the inferred transition between sedimentary sequences and metamorphic basement. At this level, the presence of a structural and lithological discontinuity favors magma storage during closed-conduit periods. The prevalent differentiation process was fractional crystallization during the magma cooling associated with upward migration of less dense, evolved liquids. Our results indicate that major steam exolution occurred during the late crystallization stage of phonolites, which accounts for the high Volcanic Explosivity Index (VEI) of eruptions supplied by these melts. Moreover, our phenocryst CSD data reveal the rapid crystallization and differentiation (decades to centuries) of alkaline Somma–Vesuvius magmas. This implies that the 400 km2 partial melting zone detected by tomography studies at 8–10 km depth beneath Vesuvius should consist of differentiated magma that is already capable of generating a large-scale (plinian) explosive event if renewed activity develops out of the present closed-conduit state. Additionally, because our microlite CSD data indicate rapid magma migration from the chamber toward the surface, precursory activity could appear only short time before a major eruption.
    Description: Published
    Description: 133–143
    Description: 2.3. TTC - Laboratori di chimica e fisica delle rocce
    Description: 3.5. Geologia e storia dei vulcani ed evoluzione dei magmi
    Description: 3.6. Fisica del vulcanismo
    Description: JCR Journal
    Description: reserved
    Keywords: residence time ; phonolite ; Vesuvius ; 04. Solid Earth::04.01. Earth Interior::04.01.04. Mineral physics and properties of rocks ; 04. Solid Earth::04.04. Geology::04.04.05. Mineralogy and petrology ; 04. Solid Earth::04.04. Geology::04.04.07. Rock geochemistry ; 04. Solid Earth::04.04. Geology::04.04.10. Stratigraphy
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 12
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    Fluid geochemistry and geothermometry in the western sector of the Sabatini Volcanic District and the Tolfa Mountains (Central Italy) (2011)
    Elsevier
    Details
    Publication Date: 2024-05-09
    Description: A geochemical survey of 197 fluid discharges (cold and thermal waters and bubbling pools) and 15 gas emissions from the western sector of the Sabatini Volcanic District and the Tolfa Mountains (Latium, Central Italy) was carried out in 2007–2008. The chemical and isotopic compositions of the fluid discharges indicate the occurrence of two main sources: 1) relatively shallow aquifers with Ca(Na,K)–HCO3 and Ca(Mg)–HCO3 compositions when trapped in volcanic and sedimentary formations, respectively; and 2) a deep reservoir, which is hosted in the Mesozoic carbonate sequence, rich in CO2 and having a Ca–SO4(HCO3) composition. Dissolution of a CO2-rich gas phase into the shallow aquifers produces high-TDS and high-pCO2 cold waters, while oxidation of deep-derived H2S to SO4 2− generates low-pH (b4) sulfate waters. The δ13C–CO2 values for gas emissions (from−2.8 to+2.7‰vs. VPDB) suggest that the origin of CO2 associated with the deep fluids ismainly related to thermo-metamorphic reactions within the carbonate reservoir, although significant mantle contribution may also occur. However, R/Ra values (0.37–0.62) indicate that He is mainly produced by a crustal source, with a minor component from a crust-contaminated mantle. On the basis of the δ13C–CH4 and δD–CH4 values (from −25.7 to −19.5‰ vs. VPDB and from −152 to −93.4‰ vs. VSMOW, respectively) CH4 production is associated with thermogenic processes, possibly related to abiogenic CO2 reduction within the carbonate reservoir. The δ34S–H2S values (from+9.3 to +10.4‰ vs. VCDT) are consistent with the hypothesis of a sedimentary source of sulfur from thermogenic reduction of Triassic sulfates. Geothermometric evaluations based on chemical equilibria CO2–CH4 and, separately, H2S suggest that the reservoir equilibriumtemperature is up to ~300 °C. The δDand δ18O data indicate thatwater recharging both the shallow and deep aquifers has a meteoric origin. Fluid geochemistry, coupled with gravimetric data and tectonic lineaments, supports the idea that significant contributions from a deep-seated geothermal brine are present in the Stigliano thermal fluid discharges. Exploration surveys investigated this area during 70's–90's for geothermal purposes. Nevertheless, presently the area is still under-exploited. The presence of thermal waters and anomalous heat flow together with the demographic growth of the last years,makes this site a suitable location for direct applications of the geothermal resource.
    Description: Published
    Description: 160-181
    Description: 2.4. TTC - Laboratori di geochimica dei fluidi
    Description: JCR Journal
    Description: reserved
    Keywords: Geochemistry Water Gas Stable isotope Geothermometry Central Italy ; 03. Hydrosphere::03.04. Chemical and biological::03.04.03. Chemistry of waters ; 03. Hydrosphere::03.04. Chemical and biological::03.04.05. Gases ; 03. Hydrosphere::03.04. Chemical and biological::03.04.06. Hydrothermal systems
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 13
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    The social sense: susceptibility to others' beliefs in human infants and adults (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-01-06
    Description: Human social interactions crucially depend on the ability to represent other agents' beliefs even when these contradict our own beliefs, leading to the potentially complex problem of simultaneously holding two conflicting representations in mind. Here, we show that adults and 7-month-olds automatically encode others' beliefs, and that, surprisingly, others' beliefs have similar effects as the participants' own beliefs. In a visual object detection task, participants' beliefs and the beliefs of an agent (whose beliefs were irrelevant to performing the task) both modulated adults' reaction times and infants' looking times. Moreover, the agent's beliefs influenced participants' behavior even after the agent had left the scene, suggesting that participants computed the agent's beliefs online and sustained them, possibly for future predictions about the agent's behavior. Hence, the mere presence of an agent automatically triggers powerful processes of belief computation that may be part of a "social sense" crucial to human societies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kovacs, Agnes Melinda -- Teglas, Erno -- Endress, Ansgar Denis -- New York, N.Y. -- Science. 2010 Dec 24;330(6012):1830-4. doi: 10.1126/science.1190792.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Psychology, Hungarian Academy of Sciences, H-1132 Budapest, Hungary. agneskovacs@mtapi.hu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21205671" target="_blank"〉PubMed〈/a〉
    Keywords: Culture ; Female ; Humans ; Infant ; Male ; Reaction Time ; *Social Perception ; *Theory of Mind ; Young Adult
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Cancer. Germ cell genes and cancer (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-01-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wu, Xiaoyun -- Ruvkun, Gary -- New York, N.Y. -- Science. 2010 Dec 24;330(6012):1761-2. doi: 10.1126/science.1200772.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA. wux@molbio.mgh.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21205660" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/growth & development/metabolism ; Brain Neoplasms/*genetics/pathology ; Caenorhabditis elegans/genetics ; *Cell Transformation, Neoplastic ; DEAD-box RNA Helicases/genetics/metabolism ; Drosophila Proteins/genetics/metabolism ; Drosophila melanogaster/*genetics ; Gene Expression Profiling ; *Gene Expression Regulation, Neoplastic ; Genes, Helminth ; *Genes, Insect ; Germ Cells/*physiology ; Humans ; RNA, Small Interfering/metabolism ; RNA, Small Untranslated/genetics/metabolism ; RNA-Binding Proteins/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 15
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    Has the microbiota played a critical role in the evolution of the adaptive immune system? (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-01-06
    Description: Although microbes have been classically viewed as pathogens, it is now well established that the majority of host-bacterial interactions are symbiotic. During development and into adulthood, gut bacteria shape the tissues, cells, and molecular profile of our gastrointestinal immune system. This partnership, forged over many millennia of coevolution, is based on a molecular exchange involving bacterial signals that are recognized by host receptors to mediate beneficial outcomes for both microbes and humans. We explore how specific aspects of the adaptive immune system are influenced by intestinal commensal bacteria. Understanding the molecular mechanisms that mediate symbiosis between commensal bacteria and humans may redefine how we view the evolution of adaptive immunity and consequently how we approach the treatment of numerous immunologic disorders.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159383/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159383/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, Yun Kyung -- Mazmanian, Sarkis K -- AI088626/AI/NIAID NIH HHS/ -- DK078938/DK/NIDDK NIH HHS/ -- DK083633/DK/NIDDK NIH HHS/ -- R01 DK078938/DK/NIDDK NIH HHS/ -- R01 DK078938-01A2/DK/NIDDK NIH HHS/ -- R01 DK078938-02/DK/NIDDK NIH HHS/ -- R01 DK078938-03/DK/NIDDK NIH HHS/ -- R01 DK078938-04/DK/NIDDK NIH HHS/ -- R21 AI088626/AI/NIAID NIH HHS/ -- R21 AI088626-01/AI/NIAID NIH HHS/ -- R21 AI088626-02/AI/NIAID NIH HHS/ -- R21 DK083633/DK/NIDDK NIH HHS/ -- R21 DK083633-01A1/DK/NIDDK NIH HHS/ -- R21 DK083633-02/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2010 Dec 24;330(6012):1768-73. doi: 10.1126/science.1195568.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21205662" target="_blank"〉PubMed〈/a〉
    Keywords: *Adaptive Immunity ; Animals ; Autoimmune Diseases/immunology ; Bacteria/immunology ; *Bacterial Physiological Phenomena ; *Biological Evolution ; Cell Differentiation ; Humans ; Immune Tolerance ; Immunity, Innate ; Immunity, Mucosal ; Intestinal Mucosa/immunology/microbiology ; Intestines/immunology/*microbiology ; Metagenome/immunology/*physiology ; Symbiosis ; T-Lymphocytes, Helper-Inducer/cytology/immunology ; T-Lymphocytes, Regulatory/cytology/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 16
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    Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-01-06
    Description: Model organisms such as the fruit fly Drosophila melanogaster can help to elucidate the molecular basis of complex diseases such as cancer. Mutations in the Drosophila gene lethal (3) malignant brain tumor cause malignant growth in the larval brain. Here we show that l(3)mbt tumors exhibited a soma-to-germline transformation through the ectopic expression of genes normally required for germline stemness, fitness, or longevity. Orthologs of some of these genes were also expressed in human somatic tumors. In addition, inactivation of any of the germline genes nanos, vasa, piwi, or aubergine suppressed l(3)mbt malignant growth. Our results demonstrate that germline traits are necessary for tumor growth in this Drosophila model and suggest that inactivation of germline genes might have tumor-suppressing effects in other species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Janic, Ana -- Mendizabal, Leire -- Llamazares, Salud -- Rossell, David -- Gonzalez, Cayetano -- New York, N.Y. -- Science. 2010 Dec 24;330(6012):1824-7. doi: 10.1126/science.1195481.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cell Division Group, Institute for Research in Biomedicine (IRB-Barcelona), PCB, c/Baldiri Reixac 10-12, Barcelona, Spain.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21205669" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Argonaute Proteins ; Brain/growth & development/metabolism ; Brain Neoplasms/*genetics/pathology ; *Cell Transformation, Neoplastic ; DEAD-box RNA Helicases/genetics/metabolism ; DNA-Binding Proteins/genetics/metabolism ; Disease Models, Animal ; Drosophila Proteins/genetics/metabolism ; *Drosophila melanogaster/genetics/growth & development/metabolism ; Gene Expression Profiling ; *Gene Expression Regulation, Neoplastic ; *Genes, Insect ; Genes, Tumor Suppressor ; Germ Cells/*physiology ; Humans ; MicroRNAs/genetics/metabolism ; Models, Animal ; Neoplasm Transplantation ; Peptide Initiation Factors/genetics/metabolism ; RNA, Small Interfering/genetics/metabolism ; RNA-Binding Proteins/genetics/metabolism ; RNA-Induced Silencing Complex/genetics/metabolism ; Transplantation, Homologous ; Up-Regulation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Healthcare venture capital for Africa (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-02-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chakma, Justin -- Sammut, Stephen M -- New York, N.Y. -- Science. 2011 Feb 4;331(6017):532-3; author reply 533-4. doi: 10.1126/science.331.6017.532-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21292953" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; Biomedical Technology/*economics ; Delivery of Health Care/*economics ; Diffusion of Innovation ; Humans ; *Investments
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Trophic downgrading of planet Earth (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-07-19
    Description: Until recently, large apex consumers were ubiquitous across the globe and had been for millions of years. The loss of these animals may be humankind's most pervasive influence on nature. Although such losses are widely viewed as an ethical and aesthetic problem, recent research reveals extensive cascading effects of their disappearance in marine, terrestrial, and freshwater ecosystems worldwide. This empirical work supports long-standing theory about the role of top-down forcing in ecosystems but also highlights the unanticipated impacts of trophic cascades on processes as diverse as the dynamics of disease, wildfire, carbon sequestration, invasive species, and biogeochemical cycles. These findings emphasize the urgent need for interdisciplinary research to forecast the effects of trophic downgrading on process, function, and resilience in global ecosystems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Estes, James A -- Terborgh, John -- Brashares, Justin S -- Power, Mary E -- Berger, Joel -- Bond, William J -- Carpenter, Stephen R -- Essington, Timothy E -- Holt, Robert D -- Jackson, Jeremy B C -- Marquis, Robert J -- Oksanen, Lauri -- Oksanen, Tarja -- Paine, Robert T -- Pikitch, Ellen K -- Ripple, William J -- Sandin, Stuart A -- Scheffer, Marten -- Schoener, Thomas W -- Shurin, Jonathan B -- Sinclair, Anthony R E -- Soule, Michael E -- Virtanen, Risto -- Wardle, David A -- New York, N.Y. -- Science. 2011 Jul 15;333(6040):301-6. doi: 10.1126/science.1205106.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolutionary Biology, University of California, Santa Cruz, CA 95060, USA. jestes@ucsc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21764740" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biodiversity ; *Ecosystem ; *Extinction, Biological ; Feeding Behavior ; *Food Chain ; Humans ; Introduced Species ; Population Dynamics ; Predatory Behavior
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Demography. China's population growing slowly, changing fast (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-05-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hvistendahl, Mara -- New York, N.Y. -- Science. 2011 May 6;332(6030):650-1. doi: 10.1126/science.332.6030.650.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21551038" target="_blank"〉PubMed〈/a〉
    Keywords: Age Distribution ; Birth Rate/trends ; Censuses ; China ; Educational Status ; Female ; Humans ; Male ; *Population Growth ; Sex Ratio ; Urban Population/statistics & numerical data/trends
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 20
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    The invisible wounds of war. Healing the brain, healing the mind (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-07-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, Greg -- New York, N.Y. -- Science. 2011 Jul 29;333(6042):514-7. doi: 10.1126/science.333.6042.514.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21798909" target="_blank"〉PubMed〈/a〉
    Keywords: Afghan Campaign 2001- ; Art Therapy ; Brain/pathology ; Brain Injuries/*diagnosis/epidemiology/pathology/psychology/*therapy ; Comorbidity ; Humans ; Iraq War, 2003-2011 ; *Military Personnel ; Stress Disorders, Post-Traumatic/*diagnosis/epidemiology/psychology/*therapy ; United States ; United States Department of Defense ; User-Computer Interface ; Veterans
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 21
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    Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-05-21
    Description: Coevolution of mammals and their gut microbiota has profoundly affected their radiation into myriad habitats. We used shotgun sequencing of microbial community DNA and targeted sequencing of bacterial 16S ribosomal RNA genes to gain an understanding of how microbial communities adapt to extremes of diet. We sampled fecal DNA from 33 mammalian species and 18 humans who kept detailed diet records, and we found that the adaptation of the microbiota to diet is similar across different mammalian lineages. Functional repertoires of microbiome genes, such as those encoding carbohydrate-active enzymes and proteases, can be predicted from bacterial species assemblages. These results illustrate the value of characterizing vertebrate gut microbiomes to understand host evolutionary histories at a supraorganismal level.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303602/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303602/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Muegge, Brian D -- Kuczynski, Justin -- Knights, Dan -- Clemente, Jose C -- Gonzalez, Antonio -- Fontana, Luigi -- Henrissat, Bernard -- Knight, Rob -- Gordon, Jeffrey I -- DK078669/DK/NIDDK NIH HHS/ -- DK30292/DK/NIDDK NIH HHS/ -- DK70977/DK/NIDDK NIH HHS/ -- P01 DK078669/DK/NIDDK NIH HHS/ -- P01 DK078669-05/DK/NIDDK NIH HHS/ -- P30 DK056341/DK/NIDDK NIH HHS/ -- P30 DK056341-11/DK/NIDDK NIH HHS/ -- R01 DK070977/DK/NIDDK NIH HHS/ -- R01 DK070977-08/DK/NIDDK NIH HHS/ -- R37 DK030292/DK/NIDDK NIH HHS/ -- R37 DK030292-31/DK/NIDDK NIH HHS/ -- T32-A1007172/PHS HHS/ -- UL1 RR024992/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2011 May 20;332(6032):970-4. doi: 10.1126/science.1198719.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21596990" target="_blank"〉PubMed〈/a〉
    Keywords: *Adaptation, Physiological ; Amino Acids/biosynthesis ; Animals ; Bacteria/classification/genetics/metabolism ; Biological Evolution ; Biostatistics ; Caloric Restriction ; *Diet ; Enzymes/genetics/metabolism ; Feces/*microbiology ; Gastrointestinal Tract/*microbiology/physiology ; Genes, Bacterial ; Genes, rRNA ; Humans ; Least-Squares Analysis ; Mammals/*microbiology/physiology ; Metagenome/*physiology ; Monte Carlo Method ; *Phylogeny ; Proteins/metabolism ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Hydropower. The legacy of the Three Gorges Dam (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-08-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, Richard -- New York, N.Y. -- Science. 2011 Aug 12;333(6044):817. doi: 10.1126/science.333.6044.817.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21835994" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; China/epidemiology ; *Ecosystem ; *Energy-Generating Resources ; *Environment ; Humans ; *Rivers ; Schistosomiasis/epidemiology/transmission ; Snails ; Water Movements
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Ethics. Bad science used to support torture and human experimentation (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-01-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Iacopino, Vincent -- Allen, Scott A -- Keller, Allen S -- New York, N.Y. -- Science. 2011 Jan 7;331(6013):34-5. doi: 10.1126/science.1194437.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Physicians for Human Rights, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21212341" target="_blank"〉PubMed〈/a〉
    Keywords: Ethics, Medical ; *Ethics, Professional ; Ethics, Research ; Federal Government ; *Human Experimentation/ethics/legislation & jurisprudence ; Humans ; *Prisoners ; *Torture/ethics/legislation & jurisprudence/psychology ; United States ; United States Department of Defense
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    9 billion? (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-07-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roberts, Leslie -- New York, N.Y. -- Science. 2011 Jul 29;333(6042):540-3. doi: 10.1126/science.333.6042.540.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21798924" target="_blank"〉PubMed〈/a〉
    Keywords: Birth Rate ; Female ; Forecasting ; Humans ; Male ; Parity ; *Population Growth ; Pregnancy
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Genomics. Deflating the genomic bubble (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-02-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Evans, James P -- Meslin, Eric M -- Marteau, Theresa M -- Caulfield, Timothy -- G0500274/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2011 Feb 18;331(6019):861-2. doi: 10.1126/science.1198039.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. jpevans@med.unc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21330519" target="_blank"〉PubMed〈/a〉
    Keywords: *Genetic Predisposition to Disease ; *Genetic Research ; Genetic Testing ; *Genetics, Medical ; *Genomics ; *Health ; Humans ; Life Style ; Pharmacogenetics ; Translational Medical Research
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Public health. Experts debate polypill: a single pill for global health (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reardon, Sara -- New York, N.Y. -- Science. 2011 Sep 30;333(6051):1813. doi: 10.1126/science.333.6051.1813.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21960602" target="_blank"〉PubMed〈/a〉
    Keywords: Cardiovascular Agents/administration & dosage ; Cardiovascular Diseases/*prevention & control ; Clinical Trials as Topic ; Developing Countries ; *Drug Combinations ; *Global Health ; Humans ; *Primary Prevention ; Risk Factors
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Following the crowd: brain substrates of long-term memory conformity (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-07-02
    Description: Human memory is strikingly susceptible to social influences, yet we know little about the underlying mechanisms. We examined how socially induced memory errors are generated in the brain by studying the memory of individuals exposed to recollections of others. Participants exhibited a strong tendency to conform to erroneous recollections of the group, producing both long-lasting and temporary errors, even when their initial memory was strong and accurate. Functional brain imaging revealed that social influence modified the neuronal representation of memory. Specifically, a particular brain signature of enhanced amygdala activity and enhanced amygdala-hippocampus connectivity predicted long-lasting but not temporary memory alterations. Our findings reveal how social manipulation can alter memory and extend the known functions of the amygdala to encompass socially mediated memory distortions.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284232/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284232/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Edelson, Micah -- Sharot, Tali -- Dolan, Raymond J -- Dudai, Yadin -- 078865/Wellcome Trust/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2011 Jul 1;333(6038):108-11. doi: 10.1126/science.1203557.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Weizmann Institute of Science, Israel. micah.edelson@weizmann.ac.il〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21719681" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Amygdala/*physiology ; Brain Mapping ; Female ; *Group Processes ; Hippocampus/*physiology ; Humans ; Magnetic Resonance Imaging ; Male ; *Mental Recall ; Social Behavior ; *Social Conformity
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Proteome half-life dynamics in living human cells (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-01-15
    Description: Cells remove proteins by two processes: degradation and dilution due to cell growth. The balance between these basic processes is poorly understood. We addressed this by developing an accurate and noninvasive method for measuring protein half-lives, called "bleach-chase," that is applicable to fluorescently tagged proteins. Assaying 100 proteins in living human cancer cells showed half-lives that ranged between 45 minutes and 22.5 hours. A variety of stresses that stop cell division showed the same general effect: Long-lived proteins became longer-lived, whereas short-lived proteins remained largely unaffected. This effect is due to the relative strengths of degradation and dilution and suggests a mechanism for differential killing of rapidly growing cells by growth-arresting drugs. This approach opens a way to understand proteome half-life dynamics in living cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eden, Eran -- Geva-Zatorsky, Naama -- Issaeva, Irina -- Cohen, Ariel -- Dekel, Erez -- Danon, Tamar -- Cohen, Lydia -- Mayo, Avi -- Alon, Uri -- New York, N.Y. -- Science. 2011 Feb 11;331(6018):764-8. doi: 10.1126/science.1199784. Epub 2011 Jan 13.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel. eraneden@gmail.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21233346" target="_blank"〉PubMed〈/a〉
    Keywords: Anaphase-Promoting Complex-Cyclosome ; Antineoplastic Agents/*pharmacology ; Camptothecin/pharmacology ; Cell Cycle Proteins/metabolism ; Cell Death ; *Cell Division/drug effects ; Cell Line, Tumor ; Cytoplasm/metabolism ; Fluorescence ; Half-Life ; Humans ; Light ; Luminescent Proteins ; Microscopy, Fluorescence ; Proteins/*metabolism ; Proteome/*metabolism ; Stress, Physiological ; Ubiquitin-Protein Ligase Complexes/metabolism
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    The cell biology of synaptic plasticity (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-11-05
    Description: Synaptic plasticity is the experience-dependent change in connectivity between neurons that is believed to underlie learning and memory. Here, we discuss the cellular and molecular processes that are altered when a neuron responds to external stimuli, and how these alterations lead to an increase or decrease in synaptic connectivity. Modification of synaptic components and changes in gene expression are necessary for many forms of plasticity. We focus on excitatory neurons in the mammalian hippocampus, one of the best-studied model systems of learning-related plasticity.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286636/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286636/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ho, Victoria M -- Lee, Ji-Ann -- Martin, Kelsey C -- R01 MH077022/MH/NIMH NIH HHS/ -- R01 MH077022-05/MH/NIMH NIH HHS/ -- R01 NS045324/NS/NINDS NIH HHS/ -- R01 NS045324-11/NS/NINDS NIH HHS/ -- R21 MH069645/MH/NIMH NIH HHS/ -- R21 MH069645-02/MH/NIMH NIH HHS/ -- T32 GM008042/GM/NIGMS NIH HHS/ -- T32 MH073526/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2011 Nov 4;334(6056):623-8. doi: 10.1126/science.1209236.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Interdepartmental Program in Neurosciences, University of California-Los Angeles (UCLA), BSRB 390B, 615 Charles E. Young Drive South, Los Angeles, CA 90095-1737, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22053042" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Gene Expression Regulation ; Hippocampus/cytology/*physiology ; Humans ; Learning/physiology ; Memory/physiology ; Neuroglia/physiology ; Neuronal Plasticity/genetics/*physiology ; Neurons/cytology/*physiology ; Synapses/physiology ; Synaptic Transmission
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Genome-sequencing anniversary. Famine in the presence of the genomic data feast (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-02-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hoal, Eileen -- New York, N.Y. -- Science. 2011 Feb 18;331(6019):874. doi: 10.1126/science.1203261.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biomedical Sciences, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21330533" target="_blank"〉PubMed〈/a〉
    Keywords: Access to Information ; Africa ; *Genetics, Medical ; *Genome, Human ; Humans ; International Cooperation
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    Association of TALS developmental disorder with defect in minor splicing component U4atac snRNA (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-04-09
    Description: The spliceosome, a ribonucleoprotein complex that includes proteins and small nuclear RNAs (snRNAs), catalyzes RNA splicing through intron excision and exon ligation to produce mature messenger RNAs, which, in turn serve as templates for protein translation. We identified four point mutations in the U4atac snRNA component of the minor spliceosome in patients with brain and bone malformations and unexplained postnatal death [microcephalic osteodysplastic primordial dwarfism type 1 (MOPD 1) or Taybi-Linder syndrome (TALS); Mendelian Inheritance in Man ID no. 210710]. Expression of a subgroup of genes, possibly linked to the disease phenotype, and minor intron splicing were affected in cell lines derived from TALS patients. Our findings demonstrate a crucial role of the minor spliceosome component U4atac snRNA in early human development and postnatal survival.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Edery, Patrick -- Marcaillou, Charles -- Sahbatou, Mourad -- Labalme, Audrey -- Chastang, Joelle -- Touraine, Renaud -- Tubacher, Emmanuel -- Senni, Faiza -- Bober, Michael B -- Nampoothiri, Sheela -- Jouk, Pierre-Simon -- Steichen, Elisabeth -- Berland, Siren -- Toutain, Annick -- Wise, Carol A -- Sanlaville, Damien -- Rousseau, Francis -- Clerget-Darpoux, Francoise -- Leutenegger, Anne-Louise -- New York, N.Y. -- Science. 2011 Apr 8;332(6026):240-3. doi: 10.1126/science.1202205.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Hospices Civils de Lyon, Service de Cytogenetique Constitutionnelle, Bron, F-69677, France. patrick.edery@chu-lyon.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21474761" target="_blank"〉PubMed〈/a〉
    Keywords: Base Pairing ; Cell Line ; Child, Preschool ; Chromosomes, Human, Pair 2/genetics ; Dwarfism/genetics/metabolism ; Female ; Fetal Growth Retardation/genetics/metabolism ; Humans ; Infant ; Introns ; Inverted Repeat Sequences ; Male ; Microcephaly/genetics/metabolism ; Microtubule-Associated Proteins/genetics ; Nucleic Acid Conformation ; Osteochondrodysplasias/genetics/metabolism ; Pedigree ; *Point Mutation ; RNA Splice Sites ; *RNA Splicing ; RNA, Small Nuclear/chemistry/*genetics/metabolism ; Spliceosomes/*genetics/metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    U. N. Summit on Noncommunicable Diseases. Meeting brings attention but little action on chronic diseases (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-09-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reardon, Sara -- New York, N.Y. -- Science. 2011 Sep 16;333(6049):1561. doi: 10.1126/science.333.6049.1561.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21921168" target="_blank"〉PubMed〈/a〉
    Keywords: Cardiovascular Diseases/epidemiology/prevention & control ; *Chronic Disease/epidemiology/prevention & control ; Congresses as Topic ; Diabetes Mellitus/epidemiology/prevention & control ; Humans ; *International Cooperation ; Neoplasms/epidemiology/prevention & control ; *Public Health ; Respiratory Tract Diseases/epidemiology/prevention & control ; *United Nations
    Print ISSN: 0036-8075
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    Medicine. Chemically tuned myosin motors (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-03-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leinwand, Leslie A -- Moss, Richard L -- New York, N.Y. -- Science. 2011 Mar 18;331(6023):1392-3. doi: 10.1126/science.1204207.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA. leinwand@colorado.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21415340" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/metabolism ; Adenosine Diphosphate/metabolism ; Adenosine Triphosphatases/metabolism ; Adenosine Triphosphate/metabolism ; Animals ; Cardiac Myosins/chemistry/*metabolism ; Heart Failure, Systolic/drug therapy ; Humans ; Myocardial Contraction/*drug effects ; Phosphates/metabolism ; Protein Binding ; Protein Isoforms/chemistry/metabolism ; Urea/*analogs & derivatives/pharmacology
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    Predicting a human gut microbiota's response to diet in gnotobiotic mice (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-05-21
    Description: The interrelationships between our diets and the structure and operations of our gut microbial communities are poorly understood. A model community of 10 sequenced human gut bacteria was introduced into gnotobiotic mice, and changes in species abundance and microbial gene expression were measured in response to randomized perturbations of four defined ingredients in the host diet. From the responses, we developed a statistical model that predicted over 60% of the variation in species abundance evoked by diet perturbations, and we were able to identify which factors in the diet best explained changes seen for each community member. The approach is generally applicable, as shown by a follow-up study involving diets containing various mixtures of pureed human baby foods.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303606/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303606/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Faith, Jeremiah J -- McNulty, Nathan P -- Rey, Federico E -- Gordon, Jeffrey I -- DK30292/DK/NIDDK NIH HHS/ -- DK70977/DK/NIDDK NIH HHS/ -- R01 DK070977/DK/NIDDK NIH HHS/ -- R01 DK070977-08/DK/NIDDK NIH HHS/ -- R37 DK030292/DK/NIDDK NIH HHS/ -- R37 DK030292-31/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2011 Jul 1;333(6038):101-4. doi: 10.1126/science.1206025. Epub 2011 May 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21596954" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacteroides/genetics/physiology ; Biomass ; Caseins/administration & dosage ; Desulfovibrio/genetics/physiology ; *Diet ; Dietary Carbohydrates/administration & dosage ; Dietary Fats, Unsaturated/administration & dosage ; Dietary Proteins/administration & dosage ; Dietary Sucrose/administration & dosage ; Escherichia coli/genetics/physiology ; Feces/*microbiology ; Gastrointestinal Tract/*microbiology ; Gene Expression Profiling ; Gene Expression Regulation, Bacterial ; *Germ-Free Life ; Gram-Negative Bacteria/*physiology ; Gram-Positive Bacteria/genetics/*physiology ; Humans ; Infant ; Infant Food ; Linear Models ; Male ; *Metagenome ; Mice ; Mice, Inbred C57BL ; Models, Animal
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    Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1 (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-07-30
    Description: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. To explore the genetic origins of this cancer, we used whole-exome sequencing and gene copy number analyses to study 32 primary tumors. Tumors from patients with a history of tobacco use had more mutations than did tumors from patients who did not use tobacco, and tumors that were negative for human papillomavirus (HPV) had more mutations than did HPV-positive tumors. Six of the genes that were mutated in multiple tumors were assessed in up to 88 additional HNSCCs. In addition to previously described mutations in TP53, CDKN2A, PIK3CA, and HRAS, we identified mutations in FBXW7 and NOTCH1. Nearly 40% of the 28 mutations identified in NOTCH1 were predicted to truncate the gene product, suggesting that NOTCH1 may function as a tumor suppressor gene rather than an oncogene in this tumor type.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162986/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162986/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Agrawal, Nishant -- Frederick, Mitchell J -- Pickering, Curtis R -- Bettegowda, Chetan -- Chang, Kyle -- Li, Ryan J -- Fakhry, Carole -- Xie, Tong-Xin -- Zhang, Jiexin -- Wang, Jing -- Zhang, Nianxiang -- El-Naggar, Adel K -- Jasser, Samar A -- Weinstein, John N -- Trevino, Lisa -- Drummond, Jennifer A -- Muzny, Donna M -- Wu, Yuanqing -- Wood, Laura D -- Hruban, Ralph H -- Westra, William H -- Koch, Wayne M -- Califano, Joseph A -- Gibbs, Richard A -- Sidransky, David -- Vogelstein, Bert -- Velculescu, Victor E -- Papadopoulos, Nickolas -- Wheeler, David A -- Kinzler, Kenneth W -- Myers, Jeffrey N -- 5P50CA09700708/CA/NCI NIH HHS/ -- CA121113/CA/NCI NIH HHS/ -- CA16672/CA/NCI NIH HHS/ -- CA43460/CA/NCI NIH HHS/ -- CA57345/CA/NCI NIH HHS/ -- CN43302/CN/NCI NIH HHS/ -- N01 CN043302/CN/NCI NIH HHS/ -- P50 CA097007/CA/NCI NIH HHS/ -- P50 CA097007-05/CA/NCI NIH HHS/ -- P50 DE019032/DE/NIDCR NIH HHS/ -- P50 DE019032-07/DE/NIDCR NIH HHS/ -- P50 DE019032-10/DE/NIDCR NIH HHS/ -- P50DE019032/DE/NIDCR NIH HHS/ -- R01 CA121113/CA/NCI NIH HHS/ -- R01 CA121113-01/CA/NCI NIH HHS/ -- R37 CA043460/CA/NCI NIH HHS/ -- R37 CA043460-16/CA/NCI NIH HHS/ -- R37 CA057345/CA/NCI NIH HHS/ -- R37 CA057345-20/CA/NCI NIH HHS/ -- R37 DE012588/DE/NIDCR NIH HHS/ -- R37 DE012588-14/DE/NIDCR NIH HHS/ -- RC2 DE020957/DE/NIDCR NIH HHS/ -- RC2 DE020957-01/DE/NIDCR NIH HHS/ -- RC2 DE020957-02/DE/NIDCR NIH HHS/ -- RC2 DE020958/DE/NIDCR NIH HHS/ -- RC2 DE020958-02/DE/NIDCR NIH HHS/ -- RC2DE020957/DE/NIDCR NIH HHS/ -- RC2DE020958/DE/NIDCR NIH HHS/ -- T32 CA009574/CA/NCI NIH HHS/ -- U54 HG003273/HG/NHGRI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2011 Aug 26;333(6046):1154-7. doi: 10.1126/science.1206923. Epub 2011 Jul 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA. nagrawal@jhmi.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21798897" target="_blank"〉PubMed〈/a〉
    Keywords: Carcinoma/drug therapy/*genetics/virology ; Carcinoma, Squamous Cell ; Cell Cycle Proteins/*genetics ; Codon, Nonsense ; Exons ; F-Box Proteins/*genetics ; Gene Dosage ; *Genes, Tumor Suppressor ; Genes, p53 ; Head and Neck Neoplasms/drug therapy/*genetics/virology ; Humans ; INDEL Mutation ; *Mutation ; Mutation, Missense ; Neoplasms, Squamous Cell/drug therapy/*genetics/virology ; Oligonucleotide Array Sequence Analysis ; Oncogenes ; Papillomaviridae/isolation & purification ; Papillomavirus Infections/virology ; Receptor, Notch1/chemistry/*genetics ; Sequence Analysis, DNA ; Smoking ; Tobacco ; Ubiquitin-Protein Ligases/*genetics
    Print ISSN: 0036-8075
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    Genome-sequencing anniversary. The genome dances (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-02-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lerman, Liz -- New York, N.Y. -- Science. 2011 Feb 25;331(6020):1027. doi: 10.1126/science.1203459.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Liz Lerman Dance Exchange, Takoma Park, MD, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21350168" target="_blank"〉PubMed〈/a〉
    Keywords: *Dancing ; Genetic Research ; *Genome, Human ; Human Genome Project ; Humans ; *Medicine in Art
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    Anthropology. The deep social structure of humankind (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-03-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chapais, Bernard -- New York, N.Y. -- Science. 2011 Mar 11;331(6022):1276-7. doi: 10.1126/science.1203281.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anthropology, University of Montreal, Montreal, Quebec, Canada. bernard.chapais@umontreal.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21393534" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Behavior, Animal ; Cooperative Behavior ; *Cultural Evolution ; *Family ; Female ; Humans ; Male ; Pair Bond ; Pan paniscus ; Pan troglodytes ; *Population Groups ; *Residence Characteristics ; *Social Behavior
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    Development of transgenic fungi that kill human malaria parasites in mosquitoes (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-02-26
    Description: Metarhizium anisopliae infects mosquitoes through the cuticle and proliferates in the hemolymph. To allow M. anisopliae to combat malaria in mosquitoes with advanced malaria infections, we produced recombinant strains expressing molecules that target sporozoites as they travel through the hemolymph to the salivary glands. Eleven days after a Plasmodium-infected blood meal, mosquitoes were treated with M. anisopliae expressing salivary gland and midgut peptide 1 (SM1), which blocks attachment of sporozoites to salivary glands; a single-chain antibody that agglutinates sporozoites; or scorpine, which is an antimicrobial toxin. These reduced sporozoite counts by 71%, 85%, and 90%, respectively. M. anisopliae expressing scorpine and an [SM1](8):scorpine fusion protein reduced sporozoite counts by 98%, suggesting that Metarhizium-mediated inhibition of Plasmodium development could be a powerful weapon for combating malaria.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153607/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153607/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fang, Weiguo -- Vega-Rodriguez, Joel -- Ghosh, Anil K -- Jacobs-Lorena, Marcelo -- Kang, Angray -- St Leger, Raymond J -- 5R21A1079429-02/PHS HHS/ -- R01 AI031478/AI/NIAID NIH HHS/ -- R21 AI079429/AI/NIAID NIH HHS/ -- R21 AI088033/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2011 Feb 25;331(6020):1074-7. doi: 10.1126/science.1199115.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Entomology, University of Maryland, 4112 Plant Sciences Building, College Park, MD 20742, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21350178" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anopheles gambiae/*microbiology/*parasitology/physiology ; Antibodies, Protozoan/immunology ; Base Sequence ; Cloning, Molecular ; Defensins/genetics/metabolism ; Feeding Behavior ; Female ; Hemolymph/metabolism/microbiology/parasitology ; Humans ; Insect Vectors/*microbiology/*parasitology/physiology ; Malaria, Falciparum/transmission ; Metarhizium/*genetics/physiology ; Molecular Sequence Data ; Oligopeptides/genetics/metabolism ; Organisms, Genetically Modified ; Pest Control, Biological ; Plasmodium falciparum/*physiology ; Protozoan Proteins/immunology ; Salivary Glands/metabolism/parasitology ; Spores, Fungal/physiology ; Sporozoites/physiology ; Transformation, Genetic ; Transgenes
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    Social psychology. Antismoking drive tries cigarette ads, in reverse (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-07-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reardon, Sara -- New York, N.Y. -- Science. 2011 Jul 1;333(6038):23-4. doi: 10.1126/science.333.6038.23.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21719652" target="_blank"〉PubMed〈/a〉
    Keywords: Advertising as Topic ; *Health Promotion ; Humans ; Peer Group ; *Product Labeling ; Psychology, Social ; *Smoking/adverse effects/prevention & control/psychology ; *Smoking Cessation/psychology ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
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    Science education. Drawing to learn in science (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-08-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ainsworth, Shaaron -- Prain, Vaughan -- Tytler, Russell -- New York, N.Y. -- Science. 2011 Aug 26;333(6046):1096-7. doi: 10.1126/science.1204153.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Psychology, University of Nottingham, University Park, Nottingham NG7 2RD, UK. shaaron.ainsworth@nottingham.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21868658" target="_blank"〉PubMed〈/a〉
    Keywords: *Art ; Child ; Communication ; Humans ; *Learning ; Science/*education ; Thinking
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    Epidemiology. A startling villain (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-03-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, Richard -- New York, N.Y. -- Science. 2011 Mar 4;331(6021):1130. doi: 10.1126/science.331.6021.1130.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21385694" target="_blank"〉PubMed〈/a〉
    Keywords: Bangladesh/epidemiology ; *Disease Outbreaks ; *Food Supply ; Humans ; Plant Poisoning/*epidemiology ; Seeds/*poisoning ; Xanthium/*poisoning
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    Cancer. New epigenetic drivers of cancers (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-03-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Elsasser, Simon J -- Allis, C David -- Lewis, Peter W -- New York, N.Y. -- Science. 2011 Mar 4;331(6021):1145-6. doi: 10.1126/science.1203280.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Chromatin Biology and Epigenetics, Rockefeller University, New York, NY 10065, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21385704" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Proteins, Signal Transducing/*genetics/metabolism ; Chromatin/metabolism ; Chromatin Assembly and Disassembly/genetics ; DNA Helicases/*genetics/metabolism ; *Epigenesis, Genetic ; *Genes, Tumor Suppressor ; Histones/metabolism ; Humans ; Mutation ; Neuroendocrine Tumors/*genetics/metabolism ; Nuclear Proteins/*genetics/metabolism ; Nucleosomes/metabolism ; Pancreatic Neoplasms/*genetics/metabolism ; Proto-Oncogene Proteins/*genetics/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism
    Print ISSN: 0036-8075
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    AIDS: let science inform policy (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-07-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fauci, Anthony S -- New York, N.Y. -- Science. 2011 Jul 1;333(6038):13. doi: 10.1126/science.1209751.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21719646" target="_blank"〉PubMed〈/a〉
    Keywords: *Acquired Immunodeficiency Syndrome/drug ; therapy/economics/epidemiology/prevention & control ; Anti-HIV Agents/therapeutic use ; Biomedical Research ; Female ; Global Health ; Health Expenditures ; *Health Policy/economics ; Humans ; Male ; Pandemics/prevention & control
    Print ISSN: 0036-8075
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    Neuroscience. Attention--voluntary control of brain cells (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-06-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roelfsema, Pieter R -- New York, N.Y. -- Science. 2011 Jun 24;332(6037):1512-3. doi: 10.1126/science.1208564.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Vision and Cognition, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, Netherlands. p.roelfsema@nin.knaw.nl〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21700861" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Attention ; Conditioning, Operant ; Eye Movements ; Frontal Lobe/physiology ; Haplorhini ; Humans ; Neurons/*physiology ; Prefrontal Cortex/cytology/*physiology ; *Visual Perception
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    Improving validation practices in "omics" research (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-12-07
    Description: "Omics" research poses acute challenges regarding how to enhance validation practices and eventually the utility of this rich information. Several strategies may be useful, including routine replication, public data and protocol availability, funding incentives, reproducibility rewards or penalties, and targeted repeatability checks.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ioannidis, John P A -- Khoury, Muin J -- New York, N.Y. -- Science. 2011 Dec 2;334(6060):1230-2. doi: 10.1126/science.1211811.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22144616" target="_blank"〉PubMed〈/a〉
    Keywords: Access to Information ; Biomedical Research/*standards ; Computational Biology ; Databases, Factual ; Genetic Research ; *Genomics ; Humans ; *Metabolomics ; *Proteomics ; Publishing ; Reproducibility of Results ; Transcriptome ; Validation Studies as Topic
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    An expanded palette of genetically encoded Ca(2)(+) indicators (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-09-10
    Description: Engineered fluorescent protein (FP) chimeras that modulate their fluorescence in response to changes in calcium ion (Ca(2+)) concentration are powerful tools for visualizing intracellular signaling activity. However, despite a decade of availability, the palette of single FP-based Ca(2+) indicators has remained limited to a single green hue. We have expanded this palette by developing blue, improved green, and red intensiometric indicators, as well as an emission ratiometric indicator with an 11,000% ratio change. This series enables improved single-color Ca(2+) imaging in neurons and transgenic Caenorhabditis elegans. In HeLa cells, Ca(2+) was imaged in three subcellular compartments, and, in conjunction with a cyan FP-yellow FP-based indicator, Ca(2+) and adenosine 5'-triphosphate were simultaneously imaged. This palette of indicators paints the way to a colorful new era of Ca(2+) imaging.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560286/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560286/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhao, Yongxin -- Araki, Satoko -- Wu, Jiahui -- Teramoto, Takayuki -- Chang, Yu-Fen -- Nakano, Masahiro -- Abdelfattah, Ahmed S -- Fujiwara, Manabi -- Ishihara, Takeshi -- Nagai, Takeharu -- Campbell, Robert E -- 94487/Canadian Institutes of Health Research/Canada -- 99085/Canadian Institutes of Health Research/Canada -- Canadian Institutes of Health Research/Canada -- New York, N.Y. -- Science. 2011 Sep 30;333(6051):1888-91. doi: 10.1126/science.1208592. Epub 2011 Sep 8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21903779" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Animals ; Animals, Genetically Modified ; Caenorhabditis elegans ; Calcium/*analysis ; *Calcium Signaling ; *Directed Molecular Evolution ; Fluorescence ; Fluorescence Resonance Energy Transfer ; Green Fluorescent Proteins/*chemistry/genetics ; HeLa Cells ; Humans ; Luminescent Proteins/*chemistry/genetics ; Molecular Sequence Data ; Neurons/metabolism ; *Protein Engineering ; Rats ; Recombinant Fusion Proteins/*chemistry ; Spectrometry, Fluorescence ; Transfection
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    The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-03-12
    Description: The growth factor progranulin (PGRN) has been implicated in embryonic development, tissue repair, tumorigenesis, and inflammation, but its receptors remain unidentified. We report that PGRN bound directly to tumor necrosis factor receptors (TNFRs) and disturbed the TNFalpha-TNFR interaction. PGRN-deficient mice were susceptible to collagen-induced arthritis, and administration of PGRN reversed inflammatory arthritis. Atsttrin, an engineered protein composed of three PGRN fragments, exhibited selective TNFR binding. PGRN and Atsttrin prevented inflammation in multiple arthritis mouse models and inhibited TNFalpha-activated intracellular signaling. Collectively, these findings demonstrate that PGRN is a ligand of TNFR, an antagonist of TNFalpha signaling, and plays a critical role in the pathogenesis of inflammatory arthritis in mice. They also suggest new potential therapeutic interventions for various TNFalpha-mediated pathologies and conditions, including rheumatoid arthritis.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104397/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104397/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tang, Wei -- Lu, Yi -- Tian, Qing-Yun -- Zhang, Yan -- Guo, Feng-Jin -- Liu, Guang-Yi -- Syed, Nabeel Muzaffar -- Lai, Yongjie -- Lin, Edward Alan -- Kong, Li -- Su, Jeffrey -- Yin, Fangfang -- Ding, Ai-Hao -- Zanin-Zhorov, Alexandra -- Dustin, Michael L -- Tao, Jian -- Craft, Joseph -- Yin, Zhinan -- Feng, Jian Q -- Abramson, Steven B -- Yu, Xiu-Ping -- Liu, Chuan-ju -- AI43542/AI/NIAID NIH HHS/ -- AR040072/AR/NIAMS NIH HHS/ -- AR050620/AR/NIAMS NIH HHS/ -- AR053210/AR/NIAMS NIH HHS/ -- GM061710/GM/NIGMS NIH HHS/ -- R01 AI030165/AI/NIAID NIH HHS/ -- R01 AI030165-20/AI/NIAID NIH HHS/ -- R01 GM061710/GM/NIGMS NIH HHS/ -- R01 GM061710-08/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2011 Apr 22;332(6028):478-84. doi: 10.1126/science.1199214. Epub 2011 Mar 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Orthopaedic Surgery, New York University School of Medicine and NYU Hospital for Joint Diseases, New York, NY 10003, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21393509" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/metabolism/pharmacology/therapeutic use ; Arthritis, Experimental/*drug therapy/*immunology/pathology/physiopathology ; Cartilage, Articular/metabolism/pathology ; Female ; Humans ; Intercellular Signaling Peptides and ; Proteins/chemistry/genetics/*metabolism/therapeutic use ; Ligands ; Male ; Mice ; Mice, Inbred Strains ; Mice, Knockout ; Mice, Transgenic ; Middle Aged ; Protein Interaction Domains and Motifs ; Receptors, Tumor Necrosis Factor, Type I/genetics/*metabolism ; Receptors, Tumor Necrosis Factor, Type II/genetics/*metabolism ; Recombinant Fusion Proteins/metabolism/pharmacology/therapeutic use ; Recombinant Proteins/therapeutic use ; Signal Transduction ; T-Lymphocytes, Regulatory/immunology/physiology ; Tumor Necrosis Factor-alpha/*metabolism ; Young Adult
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    Genomics. Genomics, biobanks, and the trade-secret model (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-04-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mitchell, Robert -- Conley, John M -- Davis, Arlene M -- Cadigan, R Jean -- Dobson, Allison W -- Gladden, Ryan Q -- P50HG004488/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2011 Apr 15;332(6027):309-10. doi: 10.1126/science.1199554.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Genome Sciences and Policy and English Department, Duke University, Durham, NC 27708, USA. rmitch@duke.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21493846" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Specimen Banks/*ethics/legislation & jurisprudence ; Databases, Genetic/*ethics/legislation & jurisprudence ; Genetic Research/*ethics ; Genomics/*ethics ; Humans ; *Informed Consent ; Patents as Topic
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    Gulf oil spill. Ten months after Deepwater Horizon, picking up the remnants of health data (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-03-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reardon, Sara -- New York, N.Y. -- Science. 2011 Mar 11;331(6022):1252. doi: 10.1126/science.331.6022.1252.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21393519" target="_blank"〉PubMed〈/a〉
    Keywords: Environmental Pollution/*adverse effects ; Follow-Up Studies ; *Health Status ; *Health Surveys ; Humans ; *Mental Health ; National Institute of Environmental Health Sciences (U.S.) ; Occupational Exposure/*adverse effects ; Petroleum/*toxicity ; Population Surveillance ; United States
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    Breakthrough of the year. Scorecard: rating last year's Areas to Watch (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-12-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 2011 Dec 23;334(6063):1632. doi: 10.1126/science.334.6063.1632.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22194550" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological/genetics ; Antibodies, Neutralizing ; Electricity ; Humans ; Malaria Vaccines ; Motor Vehicles ; Nuclear Fusion ; Physical Phenomena ; Science/*trends
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    Infectious diseases. A tropical disease hits the road (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-08-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leslie, Mitch -- New York, N.Y. -- Science. 2011 Aug 19;333(6045):934. doi: 10.1126/science.333.6045.934.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21852469" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chagas Disease/*epidemiology/transmission ; Emigrants and Immigrants/statistics & numerical data ; Humans ; Incidence ; Insect Vectors/parasitology ; Latin America/epidemiology ; Prevalence ; Reduviidae/parasitology ; Trypanosoma cruzi ; United States/epidemiology
    Print ISSN: 0036-8075
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    A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-03-12
    Description: Disruption of the circadian clock exacerbates metabolic diseases, including obesity and diabetes. We show that histone deacetylase 3 (HDAC3) recruitment to the genome displays a circadian rhythm in mouse liver. Histone acetylation is inversely related to HDAC3 binding, and this rhythm is lost when HDAC3 is absent. Although amounts of HDAC3 are constant, its genomic recruitment in liver corresponds to the expression pattern of the circadian nuclear receptor Rev-erbalpha. Rev-erbalpha colocalizes with HDAC3 near genes regulating lipid metabolism, and deletion of HDAC3 or Rev-erbalpha in mouse liver causes hepatic steatosis. Thus, genomic recruitment of HDAC3 by Rev-erbalpha directs a circadian rhythm of histone acetylation and gene expression required for normal hepatic lipid homeostasis.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389392/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389392/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Feng, Dan -- Liu, Tao -- Sun, Zheng -- Bugge, Anne -- Mullican, Shannon E -- Alenghat, Theresa -- Liu, X Shirley -- Lazar, Mitchell A -- DK19525/DK/NIDDK NIH HHS/ -- DK43806/DK/NIDDK NIH HHS/ -- DK45586/DK/NIDDK NIH HHS/ -- DK49210/DK/NIDDK NIH HHS/ -- HG4069/HG/NHGRI NIH HHS/ -- P30 DK019525/DK/NIDDK NIH HHS/ -- R01 DK045586/DK/NIDDK NIH HHS/ -- R37 DK043806/DK/NIDDK NIH HHS/ -- R37 DK043806-20/DK/NIDDK NIH HHS/ -- RC1 DK086239/DK/NIDDK NIH HHS/ -- RC1DK08623/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2011 Mar 11;331(6022):1315-9. doi: 10.1126/science.1198125.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21393543" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding Sites ; Chromatin Immunoprecipitation ; Chronobiology Disorders/genetics/metabolism ; *Circadian Clocks ; *Circadian Rhythm ; DNA/metabolism ; Epigenesis, Genetic ; Fatty Liver/*metabolism ; Gene Expression Regulation ; *Genome ; Histone Deacetylases/*metabolism ; Histones/metabolism ; Homeostasis ; *Lipid Metabolism ; Lipogenesis/genetics ; Liver/*metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Molecular Sequence Data ; Nuclear Receptor Co-Repressor 1/metabolism ; Nuclear Receptor Subfamily 1, Group D, Member 1/genetics/metabolism ; RNA Polymerase II/metabolism ; Up-Regulation
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    Revolutionizing Egypt's science. Tackling Egypt's new plague (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-07-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, Andrew -- New York, N.Y. -- Science. 2011 Jul 15;333(6040):281. doi: 10.1126/science.333.6040.281.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21764727" target="_blank"〉PubMed〈/a〉
    Keywords: Egypt ; Gold ; Hepacivirus/genetics/*isolation & purification ; Hepatitis C/*diagnosis ; Humans ; Metal Nanoparticles ; *Nanotechnology ; Qatar ; RNA, Viral/*analysis ; Technology Transfer
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    Newsmaker interview. Iran's Alaei brothers to continue AIDS work after release from prison. Interview by Yudhijit Bhattacharjee (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-10-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alaei, Arash -- Alaei, Kamiar -- New York, N.Y. -- Science. 2011 Oct 28;334(6055):444. doi: 10.1126/science.334.6055.444.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22034409" target="_blank"〉PubMed〈/a〉
    Keywords: *Acquired Immunodeficiency Syndrome/prevention & control ; *Health Promotion ; Humans ; Iran ; *Prisoners ; Prisons
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    Infectious diseases. Drug developers finally take aim at a neglected disease (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-08-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leslie, Mitch -- New York, N.Y. -- Science. 2011 Aug 19;333(6045):933-5. doi: 10.1126/science.333.6045.933.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21852468" target="_blank"〉PubMed〈/a〉
    Keywords: Chagas Disease/*drug therapy/epidemiology ; Drug Approval ; *Drug Discovery ; Drug Evaluation, Preclinical ; Drug Repositioning ; Enzyme Inhibitors/pharmacology/*therapeutic use ; High-Throughput Screening Assays ; Humans ; Neglected Diseases/*drug therapy ; Trypanocidal Agents/pharmacology/*therapeutic use ; Trypanosoma cruzi/drug effects/enzymology
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    Spatial coupling of mTOR and autophagy augments secretory phenotypes (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-04-23
    Description: Protein synthesis and autophagic degradation are regulated in an opposite manner by mammalian target of rapamycin (mTOR), whereas under certain conditions it would be beneficial if they occurred in unison to handle rapid protein turnover. We observed a distinct cellular compartment at the trans side of the Golgi apparatus, the TOR-autophagy spatial coupling compartment (TASCC), where (auto)lysosomes and mTOR accumulated during Ras-induced senescence. mTOR recruitment to the TASCC was amino acid- and Rag guanosine triphosphatase-dependent, and disruption of mTOR localization to the TASCC suppressed interleukin-6/8 synthesis. TASCC formation was observed during macrophage differentiation and in glomerular podocytes; both displayed increased protein secretion. The spatial coupling of cells' catabolic and anabolic machinery could augment their respective functions and facilitate the mass synthesis of secretory proteins.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426290/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426290/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Narita, Masako -- Young, Andrew R J -- Arakawa, Satoko -- Samarajiwa, Shamith A -- Nakashima, Takayuki -- Yoshida, Sei -- Hong, Sungki -- Berry, Lorraine S -- Reichelt, Stefanie -- Ferreira, Manuela -- Tavare, Simon -- Inoki, Ken -- Shimizu, Shigeomi -- Narita, Masashi -- DK083491/DK/NIDDK NIH HHS/ -- R01 DK083491/DK/NIDDK NIH HHS/ -- R01 DK083491-03/DK/NIDDK NIH HHS/ -- Cancer Research UK/United Kingdom -- New York, N.Y. -- Science. 2011 May 20;332(6032):966-70. doi: 10.1126/science.1205407. Epub 2011 Apr 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cancer Research UK Cambridge Research Institute (CRI), Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21512002" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acids/metabolism ; Animals ; *Autophagy ; *Cell Aging ; Cell Line ; Cytoplasm/metabolism ; Cytoplasmic Vesicles/*metabolism/ultrastructure ; Endoplasmic Reticulum, Rough/ultrastructure ; Genes, ras ; Golgi Apparatus/ultrastructure ; HL-60 Cells ; Humans ; Interleukin-6/metabolism ; Interleukin-8/metabolism ; Lysosomes/metabolism/ultrastructure ; Mice ; Monomeric GTP-Binding Proteins/genetics/metabolism ; Nocodazole/pharmacology ; Phagosomes/metabolism/ultrastructure ; Phenotype ; Podocytes/metabolism/ultrastructure ; Protein Biosynthesis ; Proteins/*secretion ; TOR Serine-Threonine Kinases/*metabolism ; Vacuoles/ultrastructure ; trans-Golgi Network/metabolism/ultrastructure
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    Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-07-23
    Description: 5-methylcytosine (5mC) in DNA plays an important role in gene expression, genomic imprinting, and suppression of transposable elements. 5mC can be converted to 5-hydroxymethylcytosine (5hmC) by the Tet (ten eleven translocation) proteins. Here, we show that, in addition to 5hmC, the Tet proteins can generate 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) from 5mC in an enzymatic activity-dependent manner. Furthermore, we reveal the presence of 5fC and 5caC in genomic DNA of mouse embryonic stem cells and mouse organs. The genomic content of 5hmC, 5fC, and 5caC can be increased or reduced through overexpression or depletion of Tet proteins. Thus, we identify two previously unknown cytosine derivatives in genomic DNA as the products of Tet proteins. Our study raises the possibility that DNA demethylation may occur through Tet-catalyzed oxidation followed by decarboxylation.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495246/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495246/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ito, Shinsuke -- Shen, Li -- Dai, Qing -- Wu, Susan C -- Collins, Leonard B -- Swenberg, James A -- He, Chuan -- Zhang, Yi -- GM071440/GM/NIGMS NIH HHS/ -- GM68804/GM/NIGMS NIH HHS/ -- P30 ES010126/ES/NIEHS NIH HHS/ -- P30 ES010126-11/ES/NIEHS NIH HHS/ -- P30ES10126/ES/NIEHS NIH HHS/ -- P42 ES005948/ES/NIEHS NIH HHS/ -- P42 ES005948-17/ES/NIEHS NIH HHS/ -- P42ES5948/ES/NIEHS NIH HHS/ -- R01 GM068804/GM/NIGMS NIH HHS/ -- U01 DK089565/DK/NIDDK NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2011 Sep 2;333(6047):1300-3. doi: 10.1126/science.1210597. Epub 2011 Jul 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21778364" target="_blank"〉PubMed〈/a〉
    Keywords: 5-Methylcytosine/*metabolism ; Animals ; Cell Line ; Cytosine/*analogs & derivatives/metabolism ; DNA/*metabolism ; DNA Methylation ; DNA-Binding Proteins/genetics/*metabolism ; Embryonic Stem Cells/metabolism ; Humans ; Mice ; Oxidation-Reduction ; Proto-Oncogene Proteins/genetics/*metabolism ; Recombinant Fusion Proteins/metabolism
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    Immunology. Regulatory T cells get their chance to shine (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-05-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leslie, Mitch -- New York, N.Y. -- Science. 2011 May 27;332(6033):1020-1. doi: 10.1126/science.332.6033.1020.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21617049" target="_blank"〉PubMed〈/a〉
    Keywords: Clinical Trials as Topic ; Diabetes Mellitus, Type 1/*therapy ; Graft Rejection/*prevention & control ; Graft vs Host Disease/*prevention & control ; Humans ; Immunosuppression/adverse effects ; Kidney Transplantation ; T-Lymphocytes, Regulatory/*immunology/*transplantation
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    Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-01-29
    Description: Proper regulation of nuclear factor kappaB (NF-kappaB) transcriptional activity is required for normal lymphocyte function, and deregulated NF-kappaB signaling can facilitate lymphomagenesis. We demonstrate that the API2-MALT1 fusion oncoprotein created by the recurrent t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma induces proteolytic cleavage of NF-kappaB-inducing kinase (NIK) at arginine 325. NIK cleavage requires the concerted actions of both fusion partners and generates a C-terminal NIK fragment that retains kinase activity and is resistant to proteasomal degradation. The resulting deregulated NIK activity is associated with constitutive noncanonical NF-kappaB signaling, enhanced B cell adhesion, and apoptosis resistance. Our study reveals the gain-of-function proteolytic activity of a fusion oncoprotein and highlights the importance of the noncanonical NF-kappaB pathway in B lymphoproliferative disease.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124150/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124150/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosebeck, Shaun -- Madden, Lisa -- Jin, Xiaohong -- Gu, Shufang -- Apel, Ingrid J -- Appert, Alex -- Hamoudi, Rifat A -- Noels, Heidi -- Sagaert, Xavier -- Van Loo, Peter -- Baens, Mathijs -- Du, Ming-Qing -- Lucas, Peter C -- McAllister-Lucas, Linda M -- R01 CA124540/CA/NCI NIH HHS/ -- R01 CA124540-04/CA/NCI NIH HHS/ -- R01 HL082914/HL/NHLBI NIH HHS/ -- R01CA124540/CA/NCI NIH HHS/ -- T32-HD07513/HD/NICHD NIH HHS/ -- T32-HL007622-21A2/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2011 Jan 28;331(6016):468-72. doi: 10.1126/science.1198946.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pediatrics and Communicable Diseases, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21273489" target="_blank"〉PubMed〈/a〉
    Keywords: Apoptosis ; B-Lymphocytes/*metabolism ; Cell Adhesion ; Cell Line ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Humans ; I-kappa B Kinase/metabolism ; Lymphoma, B-Cell, Marginal Zone/genetics/*metabolism ; NF-kappa B/*metabolism ; NF-kappa B p52 Subunit/metabolism ; Oncogene Proteins, Fusion/chemistry/genetics/*metabolism ; Phosphorylation ; Protein Structure, Tertiary ; Protein-Serine-Threonine Kinases/genetics/*metabolism ; Proto-Oncogene Proteins/genetics/metabolism ; Signal Transduction ; Substrate Specificity
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Society for American Archaeology 76th annual meeting. Searching for syphilis's origins (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-04-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, Andrew -- New York, N.Y. -- Science. 2011 Apr 22;332(6028):417. doi: 10.1126/science.332.6028.417.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21512018" target="_blank"〉PubMed〈/a〉
    Keywords: Archaeology ; History, 15th Century ; History, Medieval ; Humans ; Japan ; North America ; Syphilis/history ; Treponemal Infections/*history/transmission
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    Cancer. Priming cancer cells for death (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-11-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reed, John C -- New York, N.Y. -- Science. 2011 Nov 25;334(6059):1075-6. doi: 10.1126/science.1215568.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. jreed@sanfordburnham.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22116875" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antineoplastic Agents/*therapeutic use ; *Apoptosis ; Female ; Humans ; Male ; Mitochondria/*physiology ; Neoplasms/*drug therapy/*physiopathology
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    Breakthrough of the year. The runners-up (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-12-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 2011 Dec 23;334(6063):1629-35. doi: 10.1126/science.334.6063.1629.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22194548" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Astronomical Objects ; Biological Evolution ; Cell Aging ; Child ; Clinical Trials, Phase III as Topic ; Fossils ; Hominidae/genetics ; Humans ; Malaria Vaccines ; Metagenome ; Photosystem II Protein Complex/chemistry ; *Science ; Zeolites/chemical synthesis/chemistry
    Print ISSN: 0036-8075
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    Infectious diseases. Controversial studies give a deadly flu virus wings (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-12-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- New York, N.Y. -- Science. 2011 Dec 2;334(6060):1192-3. doi: 10.1126/science.334.6060.1192.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22144591" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bioterrorism ; Ferrets ; *Host Specificity ; Humans ; Influenza A Virus, H5N1 Subtype/*genetics/*pathogenicity ; Influenza in Birds/virology ; Influenza, Human/epidemiology/mortality/transmission/*virology ; International Cooperation ; Netherlands ; Orthomyxoviridae Infections/epidemiology/transmission/veterinary/*virology ; *Pandemics ; Poultry ; Publishing ; Serial Passage ; United States ; United States Dept. of Health and Human Services
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Boosting minorities in science (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-01-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hrabowski, Freeman A 3rd -- New York, N.Y. -- Science. 2011 Jan 14;331(6014):125. doi: 10.1126/science.1202388.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21233350" target="_blank"〉PubMed〈/a〉
    Keywords: Education, Graduate ; Engineering/education/manpower ; Humans ; Mathematics/*education/manpower ; Mentors ; Minority Groups/*education ; Science/*education/manpower ; Social Support ; United States
    Print ISSN: 0036-8075
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    Fighting liverflukes with food safety education (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-01-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ziegler, Alan D -- Andrews, Ross H -- Grundy-Warr, Carl -- Sithithaworn, Paiboon -- Petney, Trevor N -- New York, N.Y. -- Science. 2011 Jan 21;331(6015):282-3. doi: 10.1126/science.331.6015.282-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21252329" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Asia, Southeastern/epidemiology ; Child ; Fishes/*parasitology ; *Food Parasitology ; *Food Safety ; *Health Education ; Humans ; Opisthorchiasis/epidemiology/*prevention & control/transmission ; Opisthorchis
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    Cell biology. Are telomere tests ready for prime time? (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-04-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leslie, Mitch -- New York, N.Y. -- Science. 2011 Apr 22;332(6028):414-5. doi: 10.1126/science.332.6028.414.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21512015" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; *Chronic Disease ; *Cytological Techniques ; Diagnostic Services ; *Disease Susceptibility ; Female ; Health Behavior ; Humans ; In Situ Hybridization, Fluorescence ; Life Style ; Male ; Polymerase Chain Reaction ; Telomere/*physiology/*ultrastructure
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    Genetics and disease. Growth defect blocks cancer and diabetes (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-02-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leslie, Mitch -- New York, N.Y. -- Science. 2011 Feb 18;331(6019):837. doi: 10.1126/science.331.6019.837.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21330503" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Diabetes Mellitus, Type 2/*genetics/prevention & control ; Genetic Predisposition to Disease ; Human Growth Hormone/metabolism ; Humans ; Immunity, Innate/genetics ; Insulin-Like Growth Factor I/metabolism ; Laron Syndrome/*genetics ; Mice ; Neoplasms/*genetics/prevention & control ; *Point Mutation ; Receptors, Somatotropin/*genetics
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    Science breakthroughs (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-12-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alberts, Bruce -- New York, N.Y. -- Science. 2011 Dec 23;334(6063):1604. doi: 10.1126/science.1217831.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22194530" target="_blank"〉PubMed〈/a〉
    Keywords: Anti-HIV Agents/*therapeutic use ; Female ; HIV Infections/*drug therapy/*prevention & control ; Humans ; Male
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Cell biology. The power of one (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-01-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leslie, Mitch -- New York, N.Y. -- Science. 2011 Jan 7;331(6013):24-6. doi: 10.1126/science.331.6013.24-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21212334" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacterial Physiological Phenomena ; Cell Differentiation ; *Cell Physiological Phenomena ; Drug Resistance, Neoplasm ; Embryonic Development ; Genome, Bacterial ; Humans ; Microfluidic Analytical Techniques ; Neoplasm Proteins/analysis ; Neoplasms/chemistry/drug therapy ; Nucleic Acid Amplification Techniques ; Sequence Analysis, DNA ; Single-Cell Analysis/*methods
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Editorial expression of concern (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-10-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alberts, Bruce -- New York, N.Y. -- Science. 2011 Oct 21;334(6054):310. doi: 10.1126/science.334.6054.310-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22021836" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cytokines/*metabolism ; Female ; Humans ; *Inflammation ; Macrophages, Peritoneal/*enzymology ; Male ; Neutrophils/*enzymology ; Phosphotransferases (Alcohol Group Acceptor)/*metabolism ; Sepsis/*immunology ; Shock, Septic/*immunology
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    Pure reasoning in 12-month-old infants as probabilistic inference (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-05-28
    Description: Many organisms can predict future events from the statistics of past experience, but humans also excel at making predictions by pure reasoning: integrating multiple sources of information, guided by abstract knowledge, to form rational expectations about novel situations, never directly experienced. Here, we show that this reasoning is surprisingly rich, powerful, and coherent even in preverbal infants. When 12-month-old infants view complex displays of multiple moving objects, they form time-varying expectations about future events that are a systematic and rational function of several stimulus variables. Infants' looking times are consistent with a Bayesian ideal observer embodying abstract principles of object motion. The model explains infants' statistical expectations and classic qualitative findings about object cognition in younger babies, not originally viewed as probabilistic inferences.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Teglas, Erno -- Vul, Edward -- Girotto, Vittorio -- Gonzalez, Michel -- Tenenbaum, Joshua B -- Bonatti, Luca L -- New York, N.Y. -- Science. 2011 May 27;332(6033):1054-9. doi: 10.1126/science.1196404.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cognitive Development Centre, Central European University, H-1015 Budapest, Hungary.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21617069" target="_blank"〉PubMed〈/a〉
    Keywords: Bayes Theorem ; Child Development ; *Cognition ; Female ; Humans ; Infant ; Male ; Models, Statistical ; Monte Carlo Method ; *Probability ; Visual Perception
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    Editorial expression of concern (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-11-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alberts, Bruce -- New York, N.Y. -- Science. 2011 Nov 11;334(6057):760. doi: 10.1126/science.1216027. Epub 2011 Nov 1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22045832" target="_blank"〉PubMed〈/a〉
    Keywords: *Adaptation, Psychological ; *Environment ; Female ; Humans ; Male ; *Prejudice ; *Stereotyping
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    Dealing with data: fostering fidelity (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Finlayson, Alexander Edward Thomas -- New York, N.Y. -- Science. 2011 Mar 25;331(6024):1515. doi: 10.1126/science.331.6024.1515-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21436421" target="_blank"〉PubMed〈/a〉
    Keywords: Access to Information ; *Biomedical Research ; *Global Health ; Humans ; *Information Dissemination ; *International Cooperation ; *Public Health
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Single-cell tech primer (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-01-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leslie, Mitch -- New York, N.Y. -- Science. 2011 Jan 7;331(6013):24-5. doi: 10.1126/science.331.6013.24-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21212333" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Flow Cytometry ; *Gene Expression Profiling ; Humans ; *Mass Spectrometry ; Microfluidic Analytical Techniques ; Oligonucleotide Array Sequence Analysis ; Single-Cell Analysis/*methods
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    How to grow a mind: statistics, structure, and abstraction (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-03-12
    Description: In coming to understand the world-in learning concepts, acquiring language, and grasping causal relations-our minds make inferences that appear to go far beyond the data available. How do we do it? This review describes recent approaches to reverse-engineering human learning and cognitive development and, in parallel, engineering more humanlike machine learning systems. Computational models that perform probabilistic inference over hierarchies of flexibly structured representations can address some of the deepest questions about the nature and origins of human thought: How does abstract knowledge guide learning and reasoning from sparse data? What forms does our knowledge take, across different domains and tasks? And how is that abstract knowledge itself acquired?〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tenenbaum, Joshua B -- Kemp, Charles -- Griffiths, Thomas L -- Goodman, Noah D -- New York, N.Y. -- Science. 2011 Mar 11;331(6022):1279-85. doi: 10.1126/science.1192788.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. jbt@mit.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21393536" target="_blank"〉PubMed〈/a〉
    Keywords: Artificial Intelligence ; Bayes Theorem ; *Cognition ; Concept Formation ; Humans ; *Knowledge ; *Learning ; Models, Statistical ; *Theory of Mind ; *Thinking
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    De-AMPylation of the small GTPase Rab1 by the pathogen Legionella pneumophila (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-06-18
    Description: The bacterial pathogen Legionella pneumophila exploits host cell vesicle transport by transiently manipulating the activity of the small guanosine triphosphatase (GTPase) Rab1. The effector protein SidM recruits Rab1 to the Legionella-containing vacuole (LCV), where it activates Rab1 and then AMPylates it by covalently adding adenosine monophosphate (AMP). L. pneumophila GTPase-activating protein LepB inactivates Rab1 before its removal from LCVs. Because LepB cannot bind AMPylated Rab1, the molecular events leading to Rab1 inactivation are unknown. We found that the effector protein SidD from L. pneumophila catalyzed AMP release from Rab1, generating de-AMPylated Rab1 accessible for inactivation by LepB. L. pneumophila mutants lacking SidD were defective for Rab1 removal from LCVs, identifying SidD as the missing link connecting the processes of early Rab1 accumulation and subsequent Rab1 removal during infection.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209958/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209958/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Neunuebel, M Ramona -- Chen, Yang -- Gaspar, Andrew H -- Backlund, Peter S Jr -- Yergey, Alfred -- Machner, Matthias P -- ZIA HD008893-01/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2011 Jul 22;333(6041):453-6. doi: 10.1126/science.1207193. Epub 2011 Jun 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21680813" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Monophosphate/*metabolism ; Animals ; Bacterial Proteins/genetics/*metabolism ; COS Cells ; Cercopithecus aethiops ; Golgi Apparatus/metabolism ; Guanine Nucleotide Exchange Factors/metabolism ; Guanosine Monophosphate/metabolism ; Guanosine Triphosphate/metabolism ; Humans ; Legionella pneumophila/*metabolism/pathogenicity ; Ligands ; Macrophages/metabolism/microbiology ; Mice ; Mice, Inbred A ; Models, Biological ; Mutant Proteins/metabolism ; U937 Cells ; Vacuoles/metabolism/*microbiology ; rab1 GTP-Binding Proteins/*metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Infectious diseases. 'Breakthrough' deal on flu strains has modest provisions (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-04-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- New York, N.Y. -- Science. 2011 Apr 29;332(6029):525. doi: 10.1126/science.332.6029.525.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21527688" target="_blank"〉PubMed〈/a〉
    Keywords: Developing Countries ; Drug Industry ; Humans ; Influenza Vaccines ; Influenza, Human/epidemiology/prevention & control/virology ; Intellectual Property ; *International Cooperation ; *Orthomyxoviridae/isolation & purification ; Pandemics ; *World Health Organization
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Why bother? (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-02-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huang, Alice S -- New York, N.Y. -- Science. 2011 Feb 18;331(6019):821. doi: 10.1126/science.1203124.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21330495" target="_blank"〉PubMed〈/a〉
    Keywords: *Career Choice ; *Engineering ; Female ; Humans ; *Science ; *Women, Working
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    India's demographic change: opportunities and challenges (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-07-30
    Description: This paper discusses emerging demographic patterns and its opportunities and challenges for India. It investigates the specificities in the demographic transition in terms of various demographic parameters and the lack of homogeneity in the transition across states in the country. It presents some opportunities that can arise from having demographic changes, particularly the demographic dividend and interstate migration to overcome labor shortage in some parts. At the same time, there are serious challenges in the form of enhancing human capital development, addressing the issue of skewed sex ratio, and the possible rise in social and political unrest and conflict.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉James, K S -- New York, N.Y. -- Science. 2011 Jul 29;333(6042):576-80. doi: 10.1126/science.1207969.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Population Research Centre, Institute for Social and Economic Change, Bangalore 560072, India. james@isec.ac.in〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21798938" target="_blank"〉PubMed〈/a〉
    Keywords: Birth Rate ; *Demography ; Female ; Forecasting ; Humans ; India ; Male ; Mortality ; *Population Density ; *Population Dynamics ; Population Growth ; Sex Ratio
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 80
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    Infectious diseases. First specific drugs raise hopes for hepatitis C (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-04-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- New York, N.Y. -- Science. 2011 Apr 8;332(6026):159-60. doi: 10.1126/science.332.6026.159.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21474720" target="_blank"〉PubMed〈/a〉
    Keywords: Antiviral Agents/adverse effects/economics/*therapeutic use ; Clinical Trials as Topic ; Developing Countries ; Drug Approval ; Drug Therapy, Combination ; Hepacivirus/drug effects/enzymology ; Hepatitis C, Chronic/*drug therapy/virology ; Humans ; Oligopeptides/administration & dosage/economics/*therapeutic use ; Proline/adverse effects/*analogs & derivatives/economics/therapeutic use ; Protease Inhibitors/adverse effects/economics/therapeutic use ; Viral Nonstructural Proteins/antagonists & inhibitors
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 81
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    Toxicologists welcome assessment assistance (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-04-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Society of Toxicology -- Environmental Mutagen Society -- Teratology Society -- New York, N.Y. -- Science. 2011 Apr 29;332(6029):536. doi: 10.1126/science.332.6029.536-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21527697" target="_blank"〉PubMed〈/a〉
    Keywords: Environment ; Humans ; Public Health ; Risk Assessment ; *Societies, Scientific ; Toxicity Tests ; *Toxicology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 82
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    Making her life an open book to promote expanded care (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- New York, N.Y. -- Science. 2011 Mar 25;331(6024):1549. doi: 10.1126/science.331.6024.1549.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21436440" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; *Breast Neoplasms/diagnosis/prevention & control/therapy ; Canada ; *Delivery of Health Care ; Developing Countries ; Female ; *Health Knowledge, Attitudes, Practice ; Health Services Accessibility ; History, 20th Century ; History, 21st Century ; Humans ; Mexico ; *Neoplasms/diagnosis/therapy ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 83
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    Primary prevention of cancer (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-05-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huff, James -- New York, N.Y. -- Science. 2011 May 20;332(6032):916-7. doi: 10.1126/science.332.6032.916-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21596974" target="_blank"〉PubMed〈/a〉
    Keywords: *Carcinogenicity Tests ; *Carcinogens/classification/toxicity ; Environmental Exposure ; Humans ; Neoplasms/*prevention & control ; Occupational Exposure ; Primary Prevention ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 84
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    40 years of the war on cancer (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 2011 Mar 25;331(6024):1540-4. doi: 10.1126/science.331.6024.1540-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21436435" target="_blank"〉PubMed〈/a〉
    Keywords: Antineoplastic Agents/history/therapeutic use ; Biomedical Research/*history ; History, 20th Century ; History, 21st Century ; Humans ; National Cancer Institute (U.S.)/*history/legislation & jurisprudence ; Neoplasms/epidemiology/*history/therapy ; United States
    Print ISSN: 0036-8075
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  • 85
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    A push to fight cancer in the developing world (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- New York, N.Y. -- Science. 2011 Mar 25;331(6024):1548-50. doi: 10.1126/science.331.6024.1548.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21436439" target="_blank"〉PubMed〈/a〉
    Keywords: *Delivery of Health Care ; *Developing Countries ; Drug Costs ; Health Care Costs ; Humans ; International Cooperation ; *Neoplasms/economics/epidemiology/prevention & control/therapy
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 86
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    The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-04-23
    Description: Mucosal surfaces constantly encounter microbes. Toll-like receptors (TLRs) mediate recognition of microbial patterns to eliminate pathogens. By contrast, we demonstrate that the prominent gut commensal Bacteroides fragilis activates the TLR pathway to establish host-microbial symbiosis. TLR2 on CD4(+) T cells is required for B. fragilis colonization of a unique mucosal niche in mice during homeostasis. A symbiosis factor (PSA, polysaccharide A) of B. fragilis signals through TLR2 directly on Foxp3(+) regulatory T cells to promote immunologic tolerance. B. fragilis lacking PSA is unable to restrain T helper 17 cell responses and is defective in niche-specific mucosal colonization. Therefore, commensal bacteria exploit the TLR pathway to actively suppress immunity. We propose that the immune system can discriminate between pathogens and the microbiota through recognition of symbiotic bacterial molecules in a process that engenders commensal colonization.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164325/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164325/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Round, June L -- Lee, S Melanie -- Li, Jennifer -- Tran, Gloria -- Jabri, Bana -- Chatila, Talal A -- Mazmanian, Sarkis K -- AI 080002/AI/NIAID NIH HHS/ -- AI 088626/AI/NIAID NIH HHS/ -- DK 078938/DK/NIDDK NIH HHS/ -- DK 083633/DK/NIDDK NIH HHS/ -- R01 AI085090/AI/NIAID NIH HHS/ -- R01 AI085090-01/AI/NIAID NIH HHS/ -- R01 AI085090-01S1/AI/NIAID NIH HHS/ -- R01 AI085090-02/AI/NIAID NIH HHS/ -- R01 AI085090-03/AI/NIAID NIH HHS/ -- R01 DK078938/DK/NIDDK NIH HHS/ -- R01 DK078938-01A2/DK/NIDDK NIH HHS/ -- R01 DK078938-02/DK/NIDDK NIH HHS/ -- R01 DK078938-03/DK/NIDDK NIH HHS/ -- R01 DK078938-04/DK/NIDDK NIH HHS/ -- R21 AI080002/AI/NIAID NIH HHS/ -- R21 AI080002-01/AI/NIAID NIH HHS/ -- R21 AI080002-02/AI/NIAID NIH HHS/ -- R21 AI088626/AI/NIAID NIH HHS/ -- R21 AI088626-01/AI/NIAID NIH HHS/ -- R21 AI088626-02/AI/NIAID NIH HHS/ -- R21 DK083633/DK/NIDDK NIH HHS/ -- R21 DK083633-01A1/DK/NIDDK NIH HHS/ -- R21 DK083633-02/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2011 May 20;332(6032):974-7. doi: 10.1126/science.1206095. Epub 2011 Apr 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA. jround@caltech.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21512004" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacteroides fragilis/*growth & development/*immunology ; Colon/immunology/microbiology ; Germ-Free Life ; Homeostasis ; Humans ; *Immune Tolerance ; Immunity, Mucosal ; Interleukin-10/metabolism ; Intestinal Mucosa/*immunology/*microbiology ; Metagenome ; Mice ; Mice, Inbred C57BL ; Models, Biological ; Polysaccharides, Bacterial/immunology/*metabolism ; Signal Transduction ; Specific Pathogen-Free Organisms ; Symbiosis ; T-Lymphocytes, Regulatory/immunology ; Th17 Cells/immunology ; Toll-Like Receptor 2/immunology/*metabolism
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    Getting education right (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-08-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alberts, Bruce -- New York, N.Y. -- Science. 2011 Aug 19;333(6045):919. doi: 10.1126/science.1212394.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21852458" target="_blank"〉PubMed〈/a〉
    Keywords: Early Intervention (Education) ; *Education/methods/standards ; Humans ; Interdisciplinary Communication ; Science/*education
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    Editorial expression of concern (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-07-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alberts, Bruce -- New York, N.Y. -- Science. 2011 Jul 1;333(6038):35. doi: 10.1126/science.333.6038.35-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21719658" target="_blank"〉PubMed〈/a〉
    Keywords: Antibodies, Viral/blood ; Blood/virology ; Cell Line, Tumor ; Fatigue Syndrome, Chronic/*virology ; Humans ; Leukemia Virus, Murine/genetics ; Recombination, Genetic ; Retroviridae Infections/*virology ; Xenotropic murine leukemia virus-related virus/genetics/immunology/*isolation & ; purification
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    Human evolution. Did modern humans travel out of Africa via Arabia? (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-01-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, Andrew -- New York, N.Y. -- Science. 2011 Jan 28;331(6016):387. doi: 10.1126/science.331.6016.387.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21273459" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; Animals ; Arabia ; *Archaeology ; Biological Evolution ; Emigration and Immigration/*history ; History, Ancient ; Hominidae ; Humans ; United Arab Emirates
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    Genome-sequencing anniversary. Genomics and clinical relevance (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-02-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hudson, Tom -- New York, N.Y. -- Science. 2011 Feb 4;331(6017):547. doi: 10.1126/science.1202572.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Ontario Institute for Cancer Research, Toronto, Ontario, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21292965" target="_blank"〉PubMed〈/a〉
    Keywords: *Genetics, Medical ; *Genomics ; *Human Genome Project ; Humans ; *Precision Medicine ; Sequence Analysis, DNA
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  • 91
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    Computational design of proteins targeting the conserved stem region of influenza hemagglutinin (2011)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2011-05-14
    Description: We describe a general computational method for designing proteins that bind a surface patch of interest on a target macromolecule. Favorable interactions between disembodied amino acid residues and the target surface are identified and used to anchor de novo designed interfaces. The method was used to design proteins that bind a conserved surface patch on the stem of the influenza hemagglutinin (HA) from the 1918 H1N1 pandemic virus. After affinity maturation, two of the designed proteins, HB36 and HB80, bind H1 and H5 HAs with low nanomolar affinity. Further, HB80 inhibits the HA fusogenic conformational changes induced at low pH. The crystal structure of HB36 in complex with 1918/H1 HA revealed that the actual binding interface is nearly identical to that in the computational design model. Such designed binding proteins may be useful for both diagnostics and therapeutics.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164876/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164876/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fleishman, Sarel J -- Whitehead, Timothy A -- Ekiert, Damian C -- Dreyfus, Cyrille -- Corn, Jacob E -- Strauch, Eva-Maria -- Wilson, Ian A -- Baker, David -- AI057141/AI/NIAID NIH HHS/ -- AI058113/AI/NIAID NIH HHS/ -- GM080209/GM/NIGMS NIH HHS/ -- P01 AI058113/AI/NIAID NIH HHS/ -- P01 AI058113-07/AI/NIAID NIH HHS/ -- Y1-CO-1020/CO/NCI NIH HHS/ -- Y1-GM-1104/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2011 May 13;332(6031):816-21. doi: 10.1126/science.1202617.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21566186" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Amino Acid Sequence ; Binding Sites ; Computational Biology ; *Computer Simulation ; Hemagglutinin Glycoproteins, Influenza Virus/chemistry/*metabolism ; Hydrogen Bonding ; Hydrogen-Ion Concentration ; Hydrophobic and Hydrophilic Interactions ; *Models, Molecular ; Molecular Sequence Data ; Mutation ; Peptide Library ; Protein Binding ; Protein Conformation ; *Protein Engineering ; Protein Interaction Domains and Motifs ; Protein Structure, Secondary ; Proteins/*chemistry/genetics/*metabolism ; Software
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    Deep human genealogies reveal a selective advantage to be on an expanding wave front (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-11-05
    Description: Since their origin, human populations have colonized the whole planet, but the demographic processes governing range expansions are mostly unknown. We analyzed the genealogy of more than one million individuals resulting from a range expansion in Quebec between 1686 and 1960 and reconstructed the spatial dynamics of the expansion. We find that a majority of the present Saguenay Lac-Saint-Jean population can be traced back to ancestors having lived directly on or close to the wave front. Ancestors located on the front contributed significantly more to the current gene pool than those from the range core, likely due to a 20% larger effective fertility of women on the wave front. This fitness component is heritable on the wave front and not in the core, implying that this life-history trait evolves during range expansions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moreau, Claudia -- Bherer, Claude -- Vezina, Helene -- Jomphe, Michele -- Labuda, Damian -- Excoffier, Laurent -- New York, N.Y. -- Science. 2011 Nov 25;334(6059):1148-50. doi: 10.1126/science.1212880. Epub 2011 Nov 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre de Recherche, Hopital Sainte-Justine, Universite de Montreal, 3175 Cote Sainte-Catherine, Montreal, Quebec, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22052972" target="_blank"〉PubMed〈/a〉
    Keywords: *Demography ; Emigration and Immigration ; Family Characteristics ; Female ; Fertility ; *Gene Pool ; Genes ; *Genetic Fitness ; Humans ; Male ; Marriage ; *Pedigree ; *Population Dynamics ; Quebec ; Registries ; Reproduction ; *Selection, Genetic
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    Crystal structure of the dynein motor domain (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-02-19
    Description: Dyneins are microtubule-based motor proteins that power ciliary beating, transport intracellular cargos, and help to construct the mitotic spindle. Evolved from ring-shaped hexameric AAA-family adenosine triphosphatases (ATPases), dynein's large size and complexity have posed challenges for understanding its structure and mechanism. Here, we present a 6 angstrom crystal structure of a functional dimer of two ~300-kilodalton motor domains of yeast cytoplasmic dynein. The structure reveals an unusual asymmetric arrangement of ATPase domains in the ring-shaped motor domain, the manner in which the mechanical element interacts with the ATPase ring, and an unexpected interaction between two coiled coils that create a base for the microtubule binding domain. The arrangement of these elements provides clues as to how adenosine triphosphate-driven conformational changes might be transmitted across the motor domain.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169322/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169322/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carter, Andrew P -- Cho, Carol -- Jin, Lan -- Vale, Ronald D -- MC_UP_A025_1011/Medical Research Council/United Kingdom -- R01 GM097312/GM/NIGMS NIH HHS/ -- R01 GM097312-01/GM/NIGMS NIH HHS/ -- R01 GM097312-02/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2011 Mar 4;331(6021):1159-65. doi: 10.1126/science.1202393. Epub 2011 Feb 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California-San Francisco, 600 16th Street, San Francisco, CA 94158, USA. cartera@mrc-lmb.cam.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21330489" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Allosteric Regulation ; Amino Acid Sequence ; Binding Sites ; Crystallography, X-Ray ; Cytoplasmic Dyneins/*chemistry/*metabolism ; Methionine/chemistry ; Microtubules/*metabolism ; Models, Molecular ; Molecular Sequence Data ; Protein Conformation ; Protein Folding ; Protein Multimerization ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Recombinant Fusion Proteins/chemistry ; Saccharomyces cerevisiae Proteins/*chemistry/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 94
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    Genome-sequencing anniversary. A living constitution (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-02-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jasanoff, Sheila -- New York, N.Y. -- Science. 2011 Feb 18;331(6019):872. doi: 10.1126/science.1203467.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉John F. Kennedy School of Government, Harvard University, Cambridge, MA, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21330528" target="_blank"〉PubMed〈/a〉
    Keywords: Bioethical Issues ; *Genetics, Medical/ethics/legislation & jurisprudence ; *Genome, Human ; *Human Genome Project ; Humans ; Jurisprudence
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 95
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    Genome-sequencing anniversary. My genome, my identity, my health (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-02-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Royal, Charmaine D M -- New York, N.Y. -- Science. 2011 Feb 11;331(6018):690-1. doi: 10.1126/science.1203123.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Genome Sciences & Policy and Department of African and African American Studies, Duke University, Durham, NC, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21310996" target="_blank"〉PubMed〈/a〉
    Keywords: Genetic Research ; *Genome, Human ; *Health ; Human Genome Project ; Humans ; *Interdisciplinary Communication
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 96
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    Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-01-15
    Description: Satellite repeats in heterochromatin are transcribed into noncoding RNAs that have been linked to gene silencing and maintenance of chromosomal integrity. Using digital gene expression analysis, we showed that these transcripts are greatly overexpressed in mouse and human epithelial cancers. In 8 of 10 mouse pancreatic ductal adenocarcinomas (PDACs), pericentromeric satellites accounted for a mean 12% (range 1 to 50%) of all cellular transcripts, a mean 40-fold increase over that in normal tissue. In 15 of 15 human PDACs, alpha satellite transcripts were most abundant and HSATII transcripts were highly specific for cancer. Similar patterns were observed in cancers of the lung, kidney, ovary, colon, and prostate. Derepression of satellite transcripts correlated with overexpression of the long interspersed nuclear element 1 (LINE-1) retrotransposon and with aberrant expression of neuroendocrine-associated genes proximal to LINE-1 insertions. The overexpression of satellite transcripts in cancer may reflect global alterations in heterochromatin silencing and could potentially be useful as a biomarker for cancer detection.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701432/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701432/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ting, David T -- Lipson, Doron -- Paul, Suchismita -- Brannigan, Brian W -- Akhavanfard, Sara -- Coffman, Erik J -- Contino, Gianmarco -- Deshpande, Vikram -- Iafrate, A John -- Letovsky, Stan -- Rivera, Miguel N -- Bardeesy, Nabeel -- Maheswaran, Shyamala -- Haber, Daniel A -- CA129933/CA/NCI NIH HHS/ -- L30 CA142210/CA/NCI NIH HHS/ -- P01 CA117969/CA/NCI NIH HHS/ -- R01 CA129933/CA/NCI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2011 Feb 4;331(6017):593-6. doi: 10.1126/science.1200801. Epub 2011 Jan 13.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21233348" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carcinoma in Situ/genetics/pathology ; Carcinoma, Pancreatic Ductal/genetics/pathology ; Colonic Neoplasms/genetics/pathology ; DNA Methylation ; DNA, Neoplasm/genetics ; DNA, Satellite/*genetics ; Female ; Gene Expression ; Gene Expression Profiling ; Heterochromatin/chemistry/genetics ; Humans ; Long Interspersed Nucleotide Elements ; Lung Neoplasms/genetics/pathology ; Male ; Mice ; Mice, Nude ; Neoplasms/*genetics/pathology ; Neurosecretory Systems/metabolism ; Ovarian Neoplasms/genetics/pathology ; Pancreatic Neoplasms/*genetics/pathology ; Prostatic Neoplasms/genetics/pathology ; RNA, Neoplasm/*genetics/metabolism ; RNA, Untranslated/*genetics/metabolism ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 97
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    Nectins establish a checkerboard-like cellular pattern in the auditory epithelium (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-07-30
    Description: In the auditory epithelium of the cochlea, the sensory hair cells and supporting cells are arranged in a checkerboard-like fashion, but the mechanism underlying this cellular patterning is unclear. We found that mouse hair cells and supporting cells express the immunoglobulin-like adhesion molecules nectin-1 and -3, respectively, and that their interaction mediates the heterotypic adhesion between these two cell types. Genetic removal of nectin-1 or -3 disrupted the checkerboard-like pattern, inducing aberrant attachment between hair cells. When cells expressing either nectin-1 or -3 were cocultured, they arranged themselves into a mosaic pattern. Thus, nectin-1 and -3 promote the formation of the checkerboard-like pattern of the auditory epithelia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Togashi, Hideru -- Kominami, Kanoko -- Waseda, Masazumi -- Komura, Hitomi -- Miyoshi, Jun -- Takeichi, Masatoshi -- Takai, Yoshimi -- New York, N.Y. -- Science. 2011 Aug 26;333(6046):1144-7. doi: 10.1126/science.1208467. Epub 2011 Jul 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21798896" target="_blank"〉PubMed〈/a〉
    Keywords: Adherens Junctions/metabolism ; Animals ; *Cell Adhesion ; Cell Adhesion Molecules/genetics/*metabolism ; Cell Differentiation ; Cell Line ; Coculture Techniques ; HEK293 Cells ; Hair Cells, Auditory/*cytology/*metabolism ; Humans ; Mice ; Mice, Knockout ; Organ of Corti/*cytology/*metabolism ; Phenotype ; Protein Binding ; RNA, Messenger/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Data replication & reproducibility. Again, and again, and again .... Introduction (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-12-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jasny, Barbara R -- Chin, Gilbert -- Chong, Lisa -- Vignieri, Sacha -- New York, N.Y. -- Science. 2011 Dec 2;334(6060):1225. doi: 10.1126/science.334.6060.1225.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22144612" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomedical Research/standards ; Computers ; Humans ; Public Policy ; *Reproducibility of Results ; Research/*standards
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 99
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    Genome-sequencing anniversary. Presenting the human genome: now in 3D! (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-02-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ruan, Yijun -- New York, N.Y. -- Science. 2011 Feb 25;331(6020):1025-6. doi: 10.1126/science.1203602.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genome Institute of Singapore, Singapore, Republic of Singapore.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21350163" target="_blank"〉PubMed〈/a〉
    Keywords: Chromatin/*ultrastructure ; Chromosomes, Human/*ultrastructure ; *Genome, Human ; Human Genome Project ; Humans
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 100
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    Widespread RNA and DNA sequence differences in the human transcriptome (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-05-21
    Description: The transmission of information from DNA to RNA is a critical process. We compared RNA sequences from human B cells of 27 individuals to the corresponding DNA sequences from the same individuals and uncovered more than 10,000 exonic sites where the RNA sequences do not match that of the DNA. All 12 possible categories of discordances were observed. These differences were nonrandom as many sites were found in multiple individuals and in different cell types, including primary skin cells and brain tissues. Using mass spectrometry, we detected peptides that are translated from the discordant RNA sequences and thus do not correspond exactly to the DNA sequences. These widespread RNA-DNA differences in the human transcriptome provide a yet unexplored aspect of genome variation.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204392/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204392/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, Mingyao -- Wang, Isabel X -- Li, Yun -- Bruzel, Alan -- Richards, Allison L -- Toung, Jonathan M -- Cheung, Vivian G -- R01 HG005854/HG/NHGRI NIH HHS/ -- R01 HG005854-01/HG/NHGRI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2011 Jul 1;333(6038):53-8. doi: 10.1126/science.1207018. Epub 2011 May 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21596952" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Amino Acid Sequence ; B-Lymphocytes ; Base Sequence ; Cell Line ; Cerebral Cortex/cytology ; DNA/chemistry/*genetics ; Exons ; Expressed Sequence Tags ; Fibroblasts ; Gene Expression Profiling ; *Genetic Variation ; *Genome, Human ; Genotype ; Humans ; Mass Spectrometry ; Middle Aged ; Molecular Sequence Data ; Polymorphism, Single Nucleotide ; Protein Biosynthesis ; Proteins/chemistry ; Proteome/chemistry ; RNA, Messenger/chemistry/*genetics ; Sequence Analysis, DNA ; Sequence Analysis, RNA ; Skin/cytology ; Untranslated Regions
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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