Publication Date:
2011-07-30
Description:
In the auditory epithelium of the cochlea, the sensory hair cells and supporting cells are arranged in a checkerboard-like fashion, but the mechanism underlying this cellular patterning is unclear. We found that mouse hair cells and supporting cells express the immunoglobulin-like adhesion molecules nectin-1 and -3, respectively, and that their interaction mediates the heterotypic adhesion between these two cell types. Genetic removal of nectin-1 or -3 disrupted the checkerboard-like pattern, inducing aberrant attachment between hair cells. When cells expressing either nectin-1 or -3 were cocultured, they arranged themselves into a mosaic pattern. Thus, nectin-1 and -3 promote the formation of the checkerboard-like pattern of the auditory epithelia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Togashi, Hideru -- Kominami, Kanoko -- Waseda, Masazumi -- Komura, Hitomi -- Miyoshi, Jun -- Takeichi, Masatoshi -- Takai, Yoshimi -- New York, N.Y. -- Science. 2011 Aug 26;333(6046):1144-7. doi: 10.1126/science.1208467. Epub 2011 Jul 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21798896" target="_blank"〉PubMed〈/a〉
Keywords:
Adherens Junctions/metabolism
;
Animals
;
*Cell Adhesion
;
Cell Adhesion Molecules/genetics/*metabolism
;
Cell Differentiation
;
Cell Line
;
Coculture Techniques
;
HEK293 Cells
;
Hair Cells, Auditory/*cytology/*metabolism
;
Humans
;
Mice
;
Mice, Knockout
;
Organ of Corti/*cytology/*metabolism
;
Phenotype
;
Protein Binding
;
RNA, Messenger/genetics/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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