ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Publication Date: 2012-08-28
    Description: Variation on chromosome 9p21 is associated with risk of coronary artery disease (CAD). This genomic region contains the CDKN2A and CDKN2B genes which encode the cell cycle regulators p16 INK4a , p14 ARF and p15 INK4b and the ANRIL gene which encodes a non-coding RNA. Vascular smooth muscle cell (VSMC) proliferation plays an important role in the pathogenesis of atherosclerosis which causes CAD. We ascertained whether 9p21 genotype had an influence on CDKN2A/CDKN2B/ANRIL expression levels in VSMCs, VSMC proliferation and VSMC content in atherosclerotic plaques. Immunohistochemical examination showed that VSMCs in atherosclerotic lesions expressed p16 INK4a , p14 ARF and p15 INK4b . Analyses of primary cultures of VSMCs showed that the 9p21 risk genotype was associated with reduced expression of p16 INK4a , p15 INK4b and ANRIL ( P = 1.2 x 10 –5 , 1.4 x 10 –2 and 3.1 x 10 –9 ) and with increased VSMC proliferation ( P = 1.6 x 10 –2 ). Immunohistochemical analyses of atherosclerotic plaques revealed an association of the risk genotype with reduced p15 INK4b levels in VSMCs ( P = 3.7 x 10 –2 ) and higher VSMC content ( P = 5.6 x 10 –4 ) in plaques. The results of this study indicate that the 9p21 variation has an impact on CDKN2A and CDKN2B expression in VSMCs and influences VMSC proliferation, which likely represents an important mechanism for the association between this genetic locus and susceptibility to CAD.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 2
    Publication Date: 2011-02-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Evans, James P -- Meslin, Eric M -- Marteau, Theresa M -- Caulfield, Timothy -- G0500274/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2011 Feb 18;331(6019):861-2. doi: 10.1126/science.1198039.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. jpevans@med.unc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21330519" target="_blank"〉PubMed〈/a〉
    Keywords: *Genetic Predisposition to Disease ; *Genetic Research ; Genetic Testing ; *Genetics, Medical ; *Genomics ; *Health ; Humans ; Life Style ; Pharmacogenetics ; Translational Medical Research
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 3
    Publication Date: 2013-05-21
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772710/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772710/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McGuire, Amy L -- Joffe, Steven -- Koenig, Barbara A -- Biesecker, Barbara B -- McCullough, Laurence B -- Blumenthal-Barby, Jennifer S -- Caulfield, Timothy -- Terry, Sharon F -- Green, Robert C -- CA154517/CA/NCI NIH HHS/ -- HG003178/HG/NHGRI NIH HHS/ -- HG005092/HG/NHGRI NIH HHS/ -- HG006485/HG/NHGRI NIH HHS/ -- HG006492/HG/NHGRI NIH HHS/ -- HG006500/HG/NHGRI NIH HHS/ -- HG006612-02/HG/NHGRI NIH HHS/ -- HG006615/HG/NHGRI NIH HHS/ -- HG02213/HG/NHGRI NIH HHS/ -- P20 HG007243/HG/NHGRI NIH HHS/ -- R01 CA154517/CA/NCI NIH HHS/ -- R01 HG002213/HG/NHGRI NIH HHS/ -- R01 HG003178/HG/NHGRI NIH HHS/ -- R01 HG005092/HG/NHGRI NIH HHS/ -- R01-CA154517/CA/NCI NIH HHS/ -- U01 HG006485/HG/NHGRI NIH HHS/ -- U01 HG006492/HG/NHGRI NIH HHS/ -- U01 HG006500/HG/NHGRI NIH HHS/ -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2013 May 31;340(6136):1047-8. doi: 10.1126/science.1240156. Epub 2013 May 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX 77030, USA. amcguire@bcm.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23686340" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Child ; Disease/*genetics ; *Genetic Predisposition to Disease ; Genetic Testing/ethics/standards ; Genome-Wide Association Study/ethics/standards ; Genomics/*ethics/*standards ; Humans ; *Incidental Findings ; Laboratories/ethics/standards/statistics & numerical data ; Mutation/ethics ; Neoplasms/genetics ; *Practice Guidelines as Topic ; Sequence Analysis, DNA/ethics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 4
    Publication Date: 2007-09-22
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2220016/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2220016/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McGuire, Amy L -- Cho, Mildred K -- McGuire, Sean E -- Caulfield, Timothy -- P50 HG003389/HG/NHGRI NIH HHS/ -- P50 HG003389-04/HG/NHGRI NIH HHS/ -- P50HG003389/HG/NHGRI NIH HHS/ -- R01HG004333/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2007 Sep 21;317(5845):1687.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX 77030, USA. amcguire@bcm.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17885116" target="_blank"〉PubMed〈/a〉
    Keywords: Forecasting ; Genetic Privacy ; Genetic Testing ; *Genetics, Medical/ethics/trends ; *Genome, Human ; *Genomics ; Humans
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 5
    Publication Date: 2010-10-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McGuire, Amy L -- Evans, Barbara J -- Caulfield, Timothy -- Burke, Wylie -- P50HG3374-06/HG/NHGRI NIH HHS/ -- R01HG004333/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2010 Oct 8;330(6001):181-2. doi: 10.1126/science.1194006.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX 77030, USA. amcguire@bcm.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20929761" target="_blank"〉PubMed〈/a〉
    Keywords: Consumer Health Information ; Counseling ; Device Approval ; Genetic Predisposition to Disease ; Genetic Testing/*legislation & jurisprudence/*standards ; *Genome, Human ; *Government Regulation ; Health Policy ; Humans ; International Cooperation ; Internet ; Product Surveillance, Postmarketing ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 6
    Publication Date: 2016-05-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Caulfield, Timothy -- Sipp, Douglas -- Murry, Charles E -- Daley, George Q -- Kimmelman, Jonathan -- New York, N.Y. -- Science. 2016 May 13;352(6287):776-7. doi: 10.1126/science.aaf4620. Epub 2016 May 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Health Law Institute, University of Alberta, Edmonton, Alberta T6G 2H5, Canada. caulfield@ualberta.ca. ; Riken Center for Developmental Biology, Kobe, Japan, 650-0047. Keio University School of Medicine, Tokyo, Japan, 160-8582. ; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA. ; Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. ; STREAM research group, Biomedical Ethics Unit, McGill University, Montreal, Quebec H3A 1X1, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27174977" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 7
    Publication Date: 2016-05-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kimmelman, Jonathan -- Hyun, Insoo -- Benvenisty, Nissim -- Caulfield, Timothy -- Heslop, Helen E -- Murry, Charles E -- Sipp, Douglas -- Studer, Lorenz -- Sugarman, Jeremy -- Daley, George Q -- England -- Nature. 2016 May 12;533(7603):311-3. doi: 10.1038/533311a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉McGill University, Montreal, Canada, and a member of the steering committee of the International Society for Stem Cell Research's Guidelines Task Force. ; Case Western Reserve University School of Medicine, USA, and a member of the steering committee of the International Society for Stem Cell Research's Guidelines Task Force. ; Azrieli Center for Stem Cells and Genetic Research, Hebrew University, Jerusalem, Israel, and a member of the steering committee of the International Society for Stem Cell Research's Guidelines Task Force. ; Canada Research Chair in Health Law and Policy at the University of Alberta, Canada, and a member of the steering committee of the International Society for Stem Cell Research's Guidelines Task Force. ; Center for Cell and Gene Therapy at Baylor College of Medicine in Houston, Texas, USA, and a member of the steering committee of the International Society for Stem Cell Research's Guidelines Task Force. ; Departments of Pathology, Bioengineering and Medicine/Cardiology, University of Washington, Seattle, Washington, USA, and a member of the steering committee of the International Society for Stem Cell Research's Guidelines Task Force. ; RIKEN Center for Developmental Biology, Kobe, Japan, project professor at Keio University School of Medicine, Tokyo, Japan, and a member of the steering committee of the International Society for Stem Cell Research's Guidelines Task Force. ; Developmental Biology Program and director of the Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, USA, and a member of the steering committee of the International Society for Stem Cell Research's Guidelines Task Force. ; Berman Institute of Bioethics and Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA, and a member of the steering committee of the International Society for Stem Cell Research's Guidelines Task Force. ; Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA, and a member of the steering committee of the International Society for Stem Cell Research's Guidelines Task Force.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27193661" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 112 (1990), S. 3693-3695 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 9
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 110 (1988), S. 7910-7912 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 10
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 55 (1989), S. 313-314 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The high-temperature superconducting phase YBa2Cu3O7−δ has been found to be unstable with respect to and decompose into other metal oxides (Y2BaCuO5, CuO, Cu2O, BaCuO2, and others) at stresses greater than 100 MPa at temperatures from 700 to 950 °C. Hot isostatic pressing and hot uniaxial pressing were used to apply pressure to and to densify porous YBa2Cu3O7−δ. X-ray diffraction and scanning electron microscopy/x-ray spectroscopy were used to determine phase purity before and after pressing. The instability of the superconducting phase should be considered during the development of hot mechanical densification and shape-forming processes, since a limit exists for the time at temperature and pressure that the YBa2Cu3O7−δ phase can withstand before decomposing.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...