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  • 1
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    Two-Dimensional Crystallization of Hexagonal Bilayer with Moiré Patterns (2012)
    American Chemical Society (ACS)
    Details
    Publication Date: 2012-03-15
    Description: The Journal of Physical Chemistry B DOI: 10.1021/jp211369r
    Electronic ISSN: 1520-5207
    Topics: Chemistry and Pharmacology , Physics
    Published by American Chemical Society (ACS)
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  • 2
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    The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-03-12
    Description: The growth factor progranulin (PGRN) has been implicated in embryonic development, tissue repair, tumorigenesis, and inflammation, but its receptors remain unidentified. We report that PGRN bound directly to tumor necrosis factor receptors (TNFRs) and disturbed the TNFalpha-TNFR interaction. PGRN-deficient mice were susceptible to collagen-induced arthritis, and administration of PGRN reversed inflammatory arthritis. Atsttrin, an engineered protein composed of three PGRN fragments, exhibited selective TNFR binding. PGRN and Atsttrin prevented inflammation in multiple arthritis mouse models and inhibited TNFalpha-activated intracellular signaling. Collectively, these findings demonstrate that PGRN is a ligand of TNFR, an antagonist of TNFalpha signaling, and plays a critical role in the pathogenesis of inflammatory arthritis in mice. They also suggest new potential therapeutic interventions for various TNFalpha-mediated pathologies and conditions, including rheumatoid arthritis.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104397/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104397/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tang, Wei -- Lu, Yi -- Tian, Qing-Yun -- Zhang, Yan -- Guo, Feng-Jin -- Liu, Guang-Yi -- Syed, Nabeel Muzaffar -- Lai, Yongjie -- Lin, Edward Alan -- Kong, Li -- Su, Jeffrey -- Yin, Fangfang -- Ding, Ai-Hao -- Zanin-Zhorov, Alexandra -- Dustin, Michael L -- Tao, Jian -- Craft, Joseph -- Yin, Zhinan -- Feng, Jian Q -- Abramson, Steven B -- Yu, Xiu-Ping -- Liu, Chuan-ju -- AI43542/AI/NIAID NIH HHS/ -- AR040072/AR/NIAMS NIH HHS/ -- AR050620/AR/NIAMS NIH HHS/ -- AR053210/AR/NIAMS NIH HHS/ -- GM061710/GM/NIGMS NIH HHS/ -- R01 AI030165/AI/NIAID NIH HHS/ -- R01 AI030165-20/AI/NIAID NIH HHS/ -- R01 GM061710/GM/NIGMS NIH HHS/ -- R01 GM061710-08/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2011 Apr 22;332(6028):478-84. doi: 10.1126/science.1199214. Epub 2011 Mar 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Orthopaedic Surgery, New York University School of Medicine and NYU Hospital for Joint Diseases, New York, NY 10003, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21393509" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/metabolism/pharmacology/therapeutic use ; Arthritis, Experimental/*drug therapy/*immunology/pathology/physiopathology ; Cartilage, Articular/metabolism/pathology ; Female ; Humans ; Intercellular Signaling Peptides and ; Proteins/chemistry/genetics/*metabolism/therapeutic use ; Ligands ; Male ; Mice ; Mice, Inbred Strains ; Mice, Knockout ; Mice, Transgenic ; Middle Aged ; Protein Interaction Domains and Motifs ; Receptors, Tumor Necrosis Factor, Type I/genetics/*metabolism ; Receptors, Tumor Necrosis Factor, Type II/genetics/*metabolism ; Recombinant Fusion Proteins/metabolism/pharmacology/therapeutic use ; Recombinant Proteins/therapeutic use ; Signal Transduction ; T-Lymphocytes, Regulatory/immunology/physiology ; Tumor Necrosis Factor-alpha/*metabolism ; Young Adult
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Occurrence and risk assessment of NP, BPA and TCS in sewage treatment plants (2018)
    Institute of Physics (IOP)
    Details
    Publication Date: 2018-11-06
    Description: A long-term investigation, which covered 6 sampling campaigns over one year, was carried out to evaluate the occurrence, removal and risk of nonylphenol (NP), bisphenol A (BPA) and triclosan (TCS) in two full-scale sewage treatment plants (STPs) in Guangdong, South China. The target compounds were detected in every sample. The influent concentrations of NP were in the ppb level, while TCS in the ppt level. The seasonal variation in the influent was observed due to human consumption and the rainfall. Domestic sewage discharge was an important source of TCS to the STPs. Three kinds of endocrine disrupting compounds (EDCs) could not be completely removed in the STPs, and the activated sludge treatment process contributed to most of the removal of compounds. In addition, the oxic tank and the anaerobic tank both showed good removal performances for target EDCs. According to the results produced from the calculation of the risk quotient, in the STP1 effluents TCS could pose a high ri...
    Print ISSN: 1755-1307
    Electronic ISSN: 1755-1315
    Topics: Geography , Geosciences , Physics
    Published by Institute of Physics (IOP)
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  • 4
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    A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-02-16
    Description: Staphylococcus aureus produces hospital- and community-acquired infections, with methicillin-resistant S. aureus posing a serious public health threat. The golden carotenoid pigment of S. aureus, staphyloxanthin, promotes resistance to reactive oxygen species and host neutrophil-based killing, and early enzymatic steps in staphyloxanthin production resemble those for cholesterol biosynthesis. We determined the crystal structures of S. aureus dehydrosqualene synthase (CrtM) at 1.58 angstrom resolution, finding structural similarity to human squalene synthase (SQS). We screened nine SQS inhibitors and determined the structures of three, bound to CrtM. One, previously tested for cholesterol-lowering activity in humans, blocked staphyloxanthin biosynthesis in vitro (median inhibitory concentration approximately 100 nM), resulting in colorless bacteria with increased susceptibility to killing by human blood and to innate immune clearance in a mouse infection model. This finding represents proof of principle for a virulence factor-based therapy against S. aureus.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747771/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747771/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, Chia-I -- Liu, George Y -- Song, Yongcheng -- Yin, Fenglin -- Hensler, Mary E -- Jeng, Wen-Yih -- Nizet, Victor -- Wang, Andrew H-J -- Oldfield, Eric -- AI07482/AI/NIAID NIH HHS/ -- GM073216/GM/NIGMS NIH HHS/ -- GM65307/GM/NIGMS NIH HHS/ -- HD051796/HD/NICHD NIH HHS/ -- R01 GM065307/GM/NIGMS NIH HHS/ -- R01 GM065307-07/GM/NIGMS NIH HHS/ -- R01 GM073216/GM/NIGMS NIH HHS/ -- R01 GM073216-29/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2008 Mar 7;319(5868):1391-4. doi: 10.1126/science.1153018. Epub 2008 Feb 14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Biological Chemistry, Academia Sinica, Nankang, Taipei 11529, Taiwan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18276850" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Anti-Bacterial Agents/chemical synthesis/chemistry/*pharmacology/therapeutic use ; Bacterial Proteins/*antagonists & inhibitors/chemistry/isolation & ; purification/metabolism ; Cell Line ; Cell Proliferation/drug effects ; Cholesterol/biosynthesis ; Crystallography, X-Ray ; Enzyme Inhibitors/chemical synthesis/metabolism/*pharmacology ; Farnesyl-Diphosphate Farnesyltransferase/*antagonists & ; inhibitors/chemistry/isolation & purification/metabolism ; Humans ; Mice ; Molecular Sequence Data ; Organothiophosphorus Compounds/chemical ; synthesis/metabolism/*pharmacology/therapeutic use ; Polyisoprenyl Phosphates/chemistry/metabolism ; Protein Structure, Secondary ; Sesquiterpenes/chemistry/metabolism ; Staphylococcal Infections/*drug therapy/microbiology ; Staphylococcus aureus/drug effects/growth & development/metabolism/*pathogenicity ; Virulence/drug effects ; Xanthophylls/biosynthesis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Numerical simulation on impingement heat transfer characteristics in ultra fast cooling (2018)
    Institute of Physics (IOP)
    Details
    Publication Date: 2018-07-13
    Description: Numerical simulation was performed to investigate convective heat transfer at the impinging zone of non-immersed pipe jet with Fluent in the ultra fast cooling process, and some influencing factors on heat transfer such as jet direction-to-plate angle, jet pressure (velocity), nozzle-to-impinging plate spacing (height), nozzle interval, nozzle diameter, and surface temperature of the plate were analyzed and designed. The results show that, in the ultra fast cooling process, the reasonable jet direction-to-plate angle is between 30 ° and 45 °; the economic water pressure is generally about 0.6MPa no more than 1.0MPa; since nozzle-to-impinging plate spacing (height) has little influence on the heat transfer coefficient due to the large water speed, nozzle-to-impinging plate spacing (height) is generally adjusted between 300 and 400mm; the nozzle interval should be set properly according to the dynamic relationship of the nozzle diameter and the jet acting zone, besides the maximum...
    Print ISSN: 1757-8981
    Electronic ISSN: 1757-899X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Institute of Physics (IOP)
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  • 6
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    Validation of MIPAS-Envisat by correlative measurements of MIPAS-STR (2004)
    In:  EPIC3Proceedings of the Second Workshop on the Atmospheric Chemistry Validation of ENVISAT (ACVE-2) : 3 - 7 May 2004, ESA-ESRIN, Frascati, Italy / European Space Agency. [Ed.: D. Danesy]. (ESA SP ; 562), 353, ISBN: 92-9092-873-5 0379-6
    Details
    Publication Date: 2019-07-17
    Description: We report on the validation of profiles from the MIPAS-Envisat on-line processor of ESA version 4.61 with correlative measurements derived from MIPAS-STR onboard the high-altitude aircraft M55-Geophysica. The validation is made for the July 22, 2002, orbit 2051 in the region of the campaign base in Forli, Italy and for several orbits in February / March 2003 around Kiruna, northern Sweden. This paper includes a careful comparison of the MIPAS-STR data with O3 sondes and with in-situ measurements from the Geophysica obtained during ascent, descent and occasional dives. To obtain accurate N2O and CH4 profiles close to the MIPAS-Envisat tangent points we used the MIPAS-STR measurements of CFC-11 and CFC-12 and correlations obtained by the HAGAR instrument.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Conference , notRev
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  • 7
    Electronic Resource
    Electronic Resource
    Crystal structure and magnetic properties of the compound Nd5Co21B4 (2001)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 90 (2001), S. 1931-1933 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A compound Nd5Co21B4 belonging to the series Rm+nCo5m+3nB2n with m=3, n=2 has been synthesized by melt spinning. The crystal structure and magnetic properties of the compound have been studied by means of x-ray diffraction and magnetic measurements. The compound crystallizes in a hexagonal structure with space group P6/mmm. The Curie temperature, the saturation moment, and the planar anisotropy field of the compound are 570 K, 31.1 μB/f.u., and 861 kOe, respectively. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1389082
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  • 8
    Electronic Resource
    Electronic Resource
    Structural defects in self-assembled organic monolayers via combined atomic beam and x-ray diffraction (1993)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 99 (1993), S. 744-747 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We present the results of a combined He atom and x-ray diffraction study of CH3(CH2)n−1SH monolayers self assembled on Au(111) surfaces. By combining these two complementary probes, we have characterized both the surface and the interior structure of the monolayers. In both cases, we find the same structure containing four molecules per unit mesh. However, we demonstrate that there are significant differences in both the diffraction linewidths and the dependence of the linewidth upon chain length for these two techniques.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.465749
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  • 9
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    Single-cell mechanics provides a sensitive and quantitative means for probing amyloid-  peptide and neuronal cell interactions (2010)
    National Academy of Sciences
    Details
    Publication Date: 2010-07-19
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 10
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    Positioning protein molecules on surfaces: A nanoengineering approach to supramolecular chemistry (2002)
    National Academy of Sciences
    Details
    Publication Date: 2002-04-16
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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