ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Animals  (623)
  • Mice  (165)
  • Industrial Chemistry
  • Inorganic Chemistry
  • Seismology
  • American Association for the Advancement of Science (AAAS)  (623)
  • 2005-2009  (623)
  • 1950-1954
  • 2008  (623)
Collection
Keywords
Publisher
Years
  • 2005-2009  (623)
  • 1950-1954
Year
  • 1
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-04-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2008 Apr 4;320(5872):30-1. doi: 10.1126/science.320.5872.30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18388263" target="_blank"〉PubMed〈/a〉
    Keywords: *AIDS Vaccines ; Animals ; Clinical Trials as Topic ; Humans ; Models, Animal ; National Institute of Allergy and Infectious Diseases (U.S.) ; Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 2
    Publication Date: 2008-05-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gibbons, Ann -- New York, N.Y. -- Science. 2008 May 2;320(5876):608-9. doi: 10.1126/science.320.5876.608b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18451281" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Diet ; *Hominidae/anatomy & histology/classification/physiology ; Humans ; Jaw/anatomy & histology ; Molar/anatomy & histology ; Paleodontology ; Tooth Attrition
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 3
    Publication Date: 2008-03-01
    Description: Long-term potentiation (LTP) at glutamatergic synapses is considered to underlie learning and memory and is associated with the enlargement of dendritic spines. Because the consolidation of memory and LTP require protein synthesis, it is important to clarify how protein synthesis affects spine enlargement. In rat brain slices, the repetitive pairing of postsynaptic spikes and two-photon uncaging of glutamate at single spines (a spike-timing protocol) produced both immediate and gradual phases of spine enlargement in CA1 pyramidal neurons. The gradual enlargement was strongly dependent on protein synthesis and brain-derived neurotrophic factor (BDNF) action, often associated with spine twitching, and was induced specifically at the spines that were immediately enlarged by the synaptic stimulation. Thus, this spike-timing protocol is an efficient trigger for BDNF secretion and induces protein synthesis-dependent long-term enlargement at the level of single spines.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4218863/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4218863/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tanaka, Jun-Ichi -- Horiike, Yoshihiro -- Matsuzaki, Masanori -- Miyazaki, Takashi -- Ellis-Davies, Graham C R -- Kasai, Haruo -- R01 GM053395/GM/NIGMS NIH HHS/ -- R01 GM053395-12/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2008 Mar 21;319(5870):1683-7. doi: 10.1126/science.1152864. Epub 2008 Feb 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Structural Physiology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18309046" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Brain-Derived Neurotrophic Factor/*metabolism/pharmacology ; Cells, Cultured ; Dendritic Spines/*physiology/*ultrastructure ; Glutamic Acid/metabolism ; *Neuronal Plasticity ; Patch-Clamp Techniques ; *Protein Biosynthesis ; Protein Synthesis Inhibitors/pharmacology ; Pyramidal Cells/physiology/ultrastructure ; Rats ; Rats, Sprague-Dawley ; Receptor, trkB/metabolism ; Synapses/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 4
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-02-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Naeem, Shahid -- New York, N.Y. -- Science. 2008 Feb 15;319(5865):913-4. doi: 10.1126/science.1154770.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology, Evolution, and Environmental Biology, Columbia University, New York, NY 10027, USA. sn2121@columbia.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18276879" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal ; Biodiversity ; *Ecosystem ; Feeding Behavior ; *Grasshoppers ; Photosynthesis ; *Plants/metabolism ; *Predatory Behavior ; *Spiders
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 5
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-05-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leslie, Mitch -- New York, N.Y. -- Science. 2008 May 30;320(5880):1155-7. doi: 10.1126/science.320.5880.1155.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18511669" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cardiovascular Agents/therapeutic use ; Energy Metabolism/drug effects/physiology ; Humans ; Hydrogen Sulfide/*therapeutic use/toxicity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 6
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-07-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bohannon, John -- New York, N.Y. -- Science. 2008 Jul 18;321(5887):339. doi: 10.1126/science.321.5887.339a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18635775" target="_blank"〉PubMed〈/a〉
    Keywords: *Acoustics ; Animals ; Carnivora/physiology ; Hearing ; Humans ; Sleep Stages ; Speech ; Tigers/physiology ; Ursidae/physiology ; Vocalization, Animal
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 7
    Publication Date: 2008-05-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gibbons, Ann -- New York, N.Y. -- Science. 2008 May 2;320(5876):608. doi: 10.1126/science.320.5876.608a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18451280" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cattle ; DNA, Bacterial ; Evolution, Molecular ; History, Ancient ; Humans ; *Mycobacterium bovis/genetics ; *Mycobacterium tuberculosis/genetics ; Tuberculosis/*history/transmission/veterinary ; Tuberculosis, Bovine/*history/microbiology ; Zoonoses/history
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 8
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-03-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gibbons, Ann -- New York, N.Y. -- Science. 2008 Mar 21;319(5870):1599-601. doi: 10.1126/science.319.5870.1599.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18356494" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomechanical Phenomena ; Femur/*anatomy & histology ; *Fossils ; Gait ; *Hominidae/anatomy & histology/classification/physiology ; Kenya ; Posture ; *Walking
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 9
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-09-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rowley, Janet D -- Blumenthal, Thomas -- New York, N.Y. -- Science. 2008 Sep 5;321(5894):1302-4. doi: 10.1126/science.1163791.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, University of Chicago, 5841 South Maryland Avenue, MC 2115, Chicago, IL 60637, USA. jrowley@medicine.bsd.uchicago.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18772424" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Chromosomes, Human, Pair 17/genetics ; Chromosomes, Human, Pair 7/genetics ; Endometrial Neoplasms/genetics ; Endometrium/cytology/*metabolism ; Female ; Gene Fusion ; Gene Rearrangement ; Humans ; Macaca mulatta ; Menstrual Cycle ; Neoplasm Proteins/*genetics ; RNA, Guide/genetics ; RNA, Messenger/*genetics ; *Trans-Splicing ; Transcription Factors/*genetics ; *Translocation, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 10
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-03-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leslie, Mitch -- New York, N.Y. -- Science. 2008 Mar 14;319(5869):1471. doi: 10.1126/science.319.5869.1471a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18339910" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anopheles/*drug effects/physiology ; DEET/*pharmacology ; Drosophila/drug effects/physiology ; Female ; Humans ; Insect Repellents/*pharmacology ; Odors ; Olfactory Receptor Neurons/drug effects/physiology ; Receptors, Odorant/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 11
    Publication Date: 2008-05-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gibbons, Ann -- Culotta, Elizabeth -- New York, N.Y. -- Science. 2008 May 2;320(5876):609. doi: 10.1126/science.320.5876.609.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18451282" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Anthropology, Physical ; Biological Evolution ; Flight, Animal ; Hominidae ; Humans ; Locomotion ; Speech
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 12
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-08-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Running, Steven W -- New York, N.Y. -- Science. 2008 Aug 1;321(5889):652-3. doi: 10.1126/science.1159607.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Numerical Terradynamic Simulation Group, College of Forestry, University of Montana, Missoula, MT 59812, USA. swr@ntsg.umt.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18669853" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture ; Animals ; Atmosphere ; *Carbon ; Carbon Dioxide ; *Climate ; Conservation of Natural Resources ; *Ecosystem ; Fires ; Greenhouse Effect ; Humans ; Insects ; *Models, Theoretical ; Photosynthesis ; Seasons ; Trees
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 13
    Publication Date: 2008-05-24
    Description: Mammals are metagenomic in that they are composed of not only their own gene complements but also those of all of their associated microbes. To understand the coevolution of the mammals and their indigenous microbial communities, we conducted a network-based analysis of bacterial 16S ribosomal RNA gene sequences from the fecal microbiota of humans and 59 other mammalian species living in two zoos and in the wild. The results indicate that host diet and phylogeny both influence bacterial diversity, which increases from carnivory to omnivory to herbivory; that bacterial communities codiversified with their hosts; and that the gut microbiota of humans living a modern life-style is typical of omnivorous primates.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649005/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649005/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ley, Ruth E -- Hamady, Micah -- Lozupone, Catherine -- Turnbaugh, Peter J -- Ramey, Rob Roy -- Bircher, J Stephen -- Schlegel, Michael L -- Tucker, Tammy A -- Schrenzel, Mark D -- Knight, Rob -- Gordon, Jeffrey I -- DK30292/DK/NIDDK NIH HHS/ -- DK70977/DK/NIDDK NIH HHS/ -- DK78669/DK/NIDDK NIH HHS/ -- P01 DK078669/DK/NIDDK NIH HHS/ -- P01 DK078669-02/DK/NIDDK NIH HHS/ -- R01 DK030292/DK/NIDDK NIH HHS/ -- R01 DK030292-24/DK/NIDDK NIH HHS/ -- R01 DK070977/DK/NIDDK NIH HHS/ -- R01 DK070977-04/DK/NIDDK NIH HHS/ -- T32 GM065103/GM/NIGMS NIH HHS/ -- T32 GM065103-07/GM/NIGMS NIH HHS/ -- T32GM065103/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2008 Jun 20;320(5883):1647-51. doi: 10.1126/science.1155725. Epub 2008 May 22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Genome Sciences, Washington University School of Medicine, St. Louis, MO 63108, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18497261" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Animals ; Animals, Wild/classification/genetics/microbiology ; Animals, Zoo/classification/genetics/microbiology ; Bacteria/*classification/genetics/isolation & purification ; *Bacterial Physiological Phenomena ; *Biological Evolution ; Carnivora/classification/genetics/microbiology ; *Diet ; Feces/microbiology ; Gastrointestinal Tract/*microbiology ; Genes, rRNA ; Humans ; Mammals/classification/genetics/*microbiology ; Molecular Sequence Data ; *Phylogeny ; Primates/classification/genetics/microbiology ; RNA, Ribosomal, 16S/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 14
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-12-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gobes, Sharon M H -- Bolhuis, Johan J -- New York, N.Y. -- Science. 2008 Dec 19;322(5909):1789. doi: 10.1126/science.322.5909.1789a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19095924" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/physiology ; Chickens/*physiology ; Finches/*physiology ; *Learning ; Memory ; Neurons/physiology ; Sleep/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 15
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-03-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2008 Mar 28;319(5871):1782-4. doi: 10.1126/science.319.5871.1782.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18369134" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Diabetes Mellitus/genetics/therapy ; *Gene Expression Regulation ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; Heart Failure/genetics/therapy ; Humans ; *MicroRNAs/antagonists & inhibitors/genetics/physiology ; *Neoplasms/diagnosis/genetics/therapy ; RNA Precursors/administration & dosage ; *Therapeutics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 16
    Publication Date: 2008-09-20
    Description: During mouse embryogenesis, reversion of imprinted X chromosome inactivation in the pluripotent inner cell mass of the female blastocyst is initiated by the repression of Xist from the paternal X chromosome. Here we report that key factors supporting pluripotency-Nanog, Oct3/4, and Sox2-bind within Xist intron 1 in undifferentiated embryonic stem (ES) cells. Whereas Nanog null ES cells display a reversible and moderate up-regulation of Xist in the absence of any apparent modification of Oct3/4 and Sox2 binding, the drastic release of all three factors from Xist intron 1 triggers rapid ectopic accumulation of Xist RNA. We conclude that the three main genetic factors underlying pluripotency cooperate to repress Xist and thus couple X inactivation reprogramming to the control of pluripotency during embryogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Navarro, Pablo -- Chambers, Ian -- Karwacki-Neisius, Violetta -- Chureau, Corinne -- Morey, Celine -- Rougeulle, Claire -- Avner, Philip -- Biotechnology and Biological Sciences Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2008 Sep 19;321(5896):1693-5. doi: 10.1126/science.1160952.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut Pasteur, Unite de Genetique Moleculaire Murine, CNRS, URA2578, F-75015, Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18802003" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blastocyst Inner Cell Mass/metabolism ; Cell Differentiation ; Cell Line ; DNA-Binding Proteins/*metabolism ; Embryonic Stem Cells/cytology/*metabolism ; Female ; HMGB Proteins/*metabolism ; Homeodomain Proteins/genetics/*metabolism ; Introns ; Male ; Mice ; Octamer Transcription Factor-3/genetics/*metabolism ; Pluripotent Stem Cells/cytology/*metabolism ; RNA, Long Noncoding ; RNA, Untranslated/*genetics/metabolism ; SOXB1 Transcription Factors ; Transcription Factors/*metabolism ; Up-Regulation ; X Chromosome/physiology ; *X Chromosome Inactivation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 17
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-09-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roy, Kaustuv -- New York, N.Y. -- Science. 2008 Sep 12;321(5895):1451-2. doi: 10.1126/science.1163097.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section of Ecology, Behavior and Evolution, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. kroy@ucsd.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18787156" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; *Body Size ; Climate ; Ecosystem ; Extinction, Biological ; Greenhouse Effect ; Models, Biological ; Population Dynamics ; Stochastic Processes ; Temperature
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 18
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-01-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lester, Benjamin -- New York, N.Y. -- Science. 2008 Jan 11;319(5860):147. doi: 10.1126/science.319.5860.147.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18187631" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Conservation of Natural Resources/*legislation & jurisprudence ; *Mammals ; Military Science/*legislation & jurisprudence ; Pacific Ocean ; Seawater ; Sound/*adverse effects ; United States ; *Whales
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 19
    Publication Date: 2008-01-26
    Description: Although commensalism with gut microbiota exists in all metazoans, the host factors that maintain this homeostatic relationship remain largely unknown. We show that the intestinal homeobox gene Caudal regulates the commensal-gut mutualism by repressing nuclear factor kappa B-dependent antimicrobial peptide genes. Inhibition of Caudal expression in flies via RNA interference led to overexpression of antimicrobial peptides, which in turn altered the commensal population within the intestine. In particular, the dominance of one gut microbe, Gluconobacter sp. strain EW707, eventually led to gut cell apoptosis and host mortality. However, restoration of a healthy microbiota community and normal host survival in the Caudal-RNAi flies was achieved by reintroduction of the Caudal gene. These results reveal that a specific genetic deficiency within a host can profoundly influence the gut commensal microbial community and host physiology.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ryu, Ji-Hwan -- Kim, Sung-Hee -- Lee, Hyo-Young -- Bai, Jin Young -- Nam, Young-Do -- Bae, Jin-Woo -- Lee, Dong Gun -- Shin, Seung Chul -- Ha, Eun-Mi -- Lee, Won-Jae -- New York, N.Y. -- Science. 2008 Feb 8;319(5864):777-82. doi: 10.1126/science.1149357. Epub 2008 Jan 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Molecular Life Science, Ewha Woman's University and National Creative Research Initiative Center for Symbiosystem, Seoul 120-750, South Korea.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18218863" target="_blank"〉PubMed〈/a〉
    Keywords: Acetobacteraceae/growth & development ; Animals ; Animals, Genetically Modified ; Antibiosis ; Antimicrobial Cationic Peptides/biosynthesis/genetics ; Apoptosis ; Bacteria/growth & development ; Drosophila Proteins/*genetics/metabolism/physiology ; Drosophila melanogaster/genetics/*immunology/metabolism/*microbiology ; Epithelial Cells/cytology/metabolism ; Gene Expression Regulation ; *Genes, Homeobox ; Genes, Insect ; Germ-Free Life ; Gluconobacter/*growth & development/pathogenicity ; Homeodomain Proteins/*genetics/physiology ; Homeostasis ; *Immunity, Innate ; Intestines/cytology/immunology/metabolism/microbiology ; RNA Interference ; Symbiosis ; Transcription Factors/*genetics/metabolism/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 20
    Publication Date: 2008-02-23
    Description: Human genetic diversity is shaped by both demographic and biological factors and has fundamental implications for understanding the genetic basis of diseases. We studied 938 unrelated individuals from 51 populations of the Human Genome Diversity Panel at 650,000 common single-nucleotide polymorphism loci. Individual ancestry and population substructure were detectable with very high resolution. The relationship between haplotype heterozygosity and geography was consistent with the hypothesis of a serial founder effect with a single origin in sub-Saharan Africa. In addition, we observed a pattern of ancestral allele frequency distributions that reflects variation in population dynamics among geographic regions. This data set allows the most comprehensive characterization to date of human genetic variation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, Jun Z -- Absher, Devin M -- Tang, Hua -- Southwick, Audrey M -- Casto, Amanda M -- Ramachandran, Sohini -- Cann, Howard M -- Barsh, Gregory S -- Feldman, Marcus -- Cavalli-Sforza, Luigi L -- Myers, Richard M -- GM073059/GM/NIGMS NIH HHS/ -- GM28016/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2008 Feb 22;319(5866):1100-4. doi: 10.1126/science.1153717.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5120, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18292342" target="_blank"〉PubMed〈/a〉
    Keywords: Africa South of the Sahara ; Animals ; Founder Effect ; Gene Frequency ; Genetic Drift ; *Genome, Human ; Haplotypes ; Heterozygote ; Humans ; Pan troglodytes/genetics ; Pedigree ; *Polymorphism, Single Nucleotide
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 21
    Publication Date: 2008-09-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldburg, Rebecca -- Roach, Steven -- Wallinga, David -- Mellon, Margaret -- New York, N.Y. -- Science. 2008 Sep 5;321(5894):1294. doi: 10.1126/science.321.5894.1294a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18772415" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture ; *Animal Husbandry ; Animals ; Animals, Domestic/*microbiology ; Anti-Bacterial Agents/*administration & dosage ; Drug Utilization ; Humans ; Methicillin Resistance ; Staphylococcal Infections/epidemiology/transmission/veterinary ; Staphylococcus aureus/drug effects/*isolation & purification ; Swine/microbiology ; Swine Diseases/epidemiology/microbiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 22
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-06-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tewksbury, Joshua J -- Huey, Raymond B -- Deutsch, Curtis A -- New York, N.Y. -- Science. 2008 Jun 6;320(5881):1296-7. doi: 10.1126/science.1159328.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of Washington, Seattle, WA 98195, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18535231" target="_blank"〉PubMed〈/a〉
    Keywords: Acclimatization ; Amphibians/*physiology ; Animals ; *Climate ; *Ecosystem ; Fishes/*physiology ; Geography ; Oceans and Seas ; Population Dynamics ; Reptiles/*physiology ; Seasons ; Seawater ; Temperature ; *Tropical Climate
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 23
    Publication Date: 2008-12-06
    Description: A high-fat diet causes activation of the regulatory protein c-Jun NH2-terminal kinase 1 (JNK1) and triggers development of insulin resistance. JNK1 is therefore a potential target for therapeutic treatment of metabolic syndrome. We explored the mechanism of JNK1 signaling by engineering mice in which the Jnk1 gene was ablated selectively in adipose tissue. JNK1 deficiency in adipose tissue suppressed high-fat diet-induced insulin resistance in the liver. JNK1-dependent secretion of the inflammatory cytokine interleukin-6 by adipose tissue caused increased expression of liver SOCS3, a protein that induces hepatic insulin resistance. Thus, JNK1 activation in adipose tissue can cause insulin resistance in the liver.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643026/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643026/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sabio, Guadalupe -- Das, Madhumita -- Mora, Alfonso -- Zhang, Zhiyou -- Jun, John Y -- Ko, Hwi Jin -- Barrett, Tamera -- Kim, Jason K -- Davis, Roger J -- DK52530/DK/NIDDK NIH HHS/ -- R01 CA065861/CA/NCI NIH HHS/ -- R01 CA065861-14/CA/NCI NIH HHS/ -- R01 DK080756/DK/NIDDK NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2008 Dec 5;322(5907):1539-43. doi: 10.1126/science.1160794.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19056984" target="_blank"〉PubMed〈/a〉
    Keywords: Adipocytes/enzymology/*metabolism ; Adipose Tissue/enzymology/metabolism ; Animals ; Dietary Fats/administration & dosage ; Enzyme Activation ; Glucose/metabolism ; Insulin/metabolism ; Insulin Receptor Substrate Proteins/metabolism ; *Insulin Resistance ; Interleukin-6/administration & dosage/metabolism ; Liver/*metabolism ; MAP Kinase Signaling System ; Mice ; Mitogen-Activated Protein Kinase 8/deficiency/genetics/*metabolism ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism ; *Signal Transduction ; *Stress, Physiological ; Suppressor of Cytokine Signaling Proteins/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 24
    Publication Date: 2008-02-23
    Description: Although strong and stiff human-made composites have long been developed, the microstructure of today's most advanced composites has yet to achieve the order and sophisticated hierarchy of hybrid materials built up by living organisms in nature. Clay-based nanocomposites with layered structure can reach notable stiffness and strength, but these properties are usually not accompanied by the ductility and flaw tolerance found in the structures generated by natural hybrid materials. By using principles found in natural composites, we showed that layered hybrid films combining high tensile strength and ductile behavior can be obtained through the bottom-up colloidal assembly of strong submicrometer-thick ceramic platelets within a ductile polymer matrix.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bonderer, Lorenz J -- Studart, Andre R -- Gauckler, Ludwig J -- New York, N.Y. -- Science. 2008 Feb 22;319(5866):1069-73. doi: 10.1126/science.1148726.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Materials, Eidgenossische Technische Hochschule (ETH)-Zurich, 8093 Zurich, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18292337" target="_blank"〉PubMed〈/a〉
    Keywords: Aluminum Oxide/chemistry ; Animals ; *Biomimetic Materials/chemistry ; Ceramics/chemistry ; Chitosan/chemistry ; Colloids ; Mollusca ; *Nanocomposites/chemistry ; *Polymers/chemistry ; Tensile Strength
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 25
    Publication Date: 2008-01-26
    Description: The hippocampus is an area of the brain involved in learning and memory. It contains parallel excitatory pathways referred to as the trisynaptic pathway (which carries information as follows: entorhinal cortex --〉 dentate gyrus --〉 CA3 --〉 CA1 --〉 entorhinal cortex) and the monosynaptic pathway (entorhinal cortex --〉 CA1 --〉 entorhinal cortex). We developed a generally applicable tetanus toxin-based method for transgenic mice that permits inducible and reversible inhibition of synaptic transmission and applied it to the trisynaptic pathway while preserving transmission in the monosynaptic pathway. We found that synaptic output from CA3 in the trisynaptic pathway is dispensable and the short monosynaptic pathway is sufficient for incremental spatial learning. In contrast, the full trisynaptic pathway containing CA3 is required for rapid one-trial contextual learning, for pattern completion-based memory recall, and for spatial tuning of CA1 cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nakashiba, Toshiaki -- Young, Jennie Z -- McHugh, Thomas J -- Buhl, Derek L -- Tonegawa, Susumu -- P50-MH58880/MH/NIMH NIH HHS/ -- R01-MH078821/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2008 Feb 29;319(5867):1260-4. doi: 10.1126/science.1151120. Epub 2008 Jan 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Picower Institute for Learning and Memory, Howard Hughes Medical Institute, RIKEN-MIT Neuroscience Research Center, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18218862" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Crosses, Genetic ; Dentate Gyrus/physiology ; Electrophysiology ; Entorhinal Cortex/physiology ; Excitatory Postsynaptic Potentials ; Female ; Hippocampus/*physiology ; Interneurons/physiology ; Male ; *Maze Learning ; Mental Recall ; Metalloendopeptidases/genetics ; Mice ; Mice, Transgenic ; Neural Pathways ; Pyramidal Cells/*physiology ; *Synaptic Transmission ; Tetanus Toxin/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 26
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-07-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2008 Jul 4;321(5885):31-3. doi: 10.1126/science.321.5885.31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18599753" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anticonvulsants/therapeutic use ; Apnea/physiopathology ; Brain/physiopathology ; Death, Sudden/epidemiology/*etiology ; Electroencephalography ; Epilepsy/drug therapy/genetics/*physiopathology ; Epilepsy, Tonic-Clonic/drug therapy/genetics/*physiopathology ; Heart Arrest/physiopathology ; Heart Rate ; Humans ; Mice ; Mutation ; NAV1.1 Voltage-Gated Sodium Channel ; Nerve Tissue Proteins/genetics ; Serotonin/physiology ; Sodium Channels/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 27
    Publication Date: 2008-05-20
    Description: Cannabinoid receptor 1 (CB1R) regulates neuronal differentiation. To understand the logic underlying decision-making in the signaling network controlling CB1R-induced neurite outgrowth, we profiled the activation of several hundred transcription factors after cell stimulation. We assembled an in silico signaling network by connecting CB1R to 23 activated transcription factors. Statistical analyses of this network predicted a role for the breast cancer 1 protein BRCA1 in neuronal differentiation and a new pathway from CB1R through phosphoinositol 3-kinase to the transcription factor paired box 6 (PAX6). Both predictions were experimentally confirmed. Results of transcription factor activation experiments that used pharmacological inhibitors of kinases revealed a network organization of partial OR gates regulating kinases stacked above AND gates that control transcription factors, which together allow for distributed decision-making in CB1R-induced neurite outgrowth.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776723/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776723/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bromberg, Kenneth D -- Ma'ayan, Avi -- Neves, Susana R -- Iyengar, Ravi -- 1 S10 RR0 9145-01/RR/NCRR NIH HHS/ -- 5R24 CA095823-04/CA/NCI NIH HHS/ -- GM072853/GM/NIGMS NIH HHS/ -- GM54508/GM/NIGMS NIH HHS/ -- P50 GM071558/GM/NIGMS NIH HHS/ -- P50 GM071558-01A2/GM/NIGMS NIH HHS/ -- P50 GM071558-01A20007/GM/NIGMS NIH HHS/ -- P50 GM071558-02/GM/NIGMS NIH HHS/ -- P50 GM071558-020007/GM/NIGMS NIH HHS/ -- P50 GM071558-030007/GM/NIGMS NIH HHS/ -- P50-071558/PHS HHS/ -- R01 GM054508/GM/NIGMS NIH HHS/ -- R01 GM054508-21/GM/NIGMS NIH HHS/ -- R01 GM072853/GM/NIGMS NIH HHS/ -- R01 GM072853-04/GM/NIGMS NIH HHS/ -- T32 CA88796/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2008 May 16;320(5878):903-9. doi: 10.1126/science.1152662.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18487186" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; BRCA1 Protein/metabolism ; Cell Differentiation ; Cell Line, Tumor ; Cells, Cultured ; Computational Biology ; Computer Simulation ; Eye Proteins/metabolism ; Hippocampus/cytology ; Homeodomain Proteins/metabolism ; Metabolic Networks and Pathways ; Mice ; Neurites/*physiology ; Neurons/*cytology/metabolism ; Paired Box Transcription Factors/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Protein Interaction Mapping ; Rats ; Receptor, Cannabinoid, CB1/*metabolism ; Repressor Proteins/metabolism ; *Signal Transduction ; Transcription Factors/antagonists & inhibitors/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 28
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-01-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grove, Elizabeth A -- New York, N.Y. -- Science. 2008 Jan 18;319(5861):288-9. doi: 10.1126/science.1153743.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, University of Chicago, Chicago, IL 60637, USA. egrove@bsd.uchicago.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18202278" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Body Patterning ; Brain Tissue Transplantation ; Cell Adhesion ; Cerebral Cortex/cytology/*embryology/transplantation ; Dentate Gyrus/embryology ; Hippocampus/cytology/*embryology ; Homeodomain Proteins/genetics/*metabolism ; LIM-Homeodomain Proteins ; Memory ; Mice ; Organizers, Embryonic/embryology/*physiology ; Prosencephalon/cytology/embryology ; Pyramidal Cells/embryology ; Transcription Factors/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 29
    Publication Date: 2008-08-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tobacman, Joanne K -- Bhattacharyya, Sumit -- Borthakur, Alip -- Dudeja, Pradeep K -- New York, N.Y. -- Science. 2008 Aug 22;321(5892):1040-1. doi: 10.1126/science.321.5892.1040d.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18719267" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Carrageenan/administration & dosage/analysis/biosynthesis/toxicity ; Ecosystem ; *Food Additives/administration & dosage/analysis/toxicity ; Humans ; Nutrition Policy ; Rhodophyta/growth & development/metabolism ; Seaweed/growth & development/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 30
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-01-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schreiber, Hans -- Rowley, Donald A -- New York, N.Y. -- Science. 2008 Jan 11;319(5860):164-5. doi: 10.1126/science.1153713.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, University of Chicago, Chicago, IL 60637, USA. hszz@midway.uchicago.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18187644" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigen Presentation ; Antigens, Neoplasm/genetics/*immunology ; Autoantigens/*immunology ; Autoimmunity ; CD8-Positive T-Lymphocytes/*immunology ; Histones/*immunology ; Humans ; Immunotherapy, Adoptive ; Lymphocytes, Tumor-Infiltrating/*immunology ; Male ; Mice ; Mutation ; Peptide Fragments/immunology ; Prostatic Neoplasms/genetics/*immunology/therapy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 31
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-12-06
    Description: Branching morphogenesis is one of the earliest events essential for the success of metazoans. By branching out and forming cellular or tissue extensions, cells can maximize their surface area and overcome space constraints posed by organ size. Over the past decade, tremendous progress has been made toward understanding the branching mechanisms of various invertebrate and vertebrate organ systems. Despite their distinct origins, morphologies and functions, different cell and tissue types use a remarkably conserved set of tools to undergo branching morphogenesis. Recent studies have shed important light on the basis of molecular conservation in the formation of branched structures in diverse organs.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645229/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645229/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lu, Pengfei -- Werb, Zena -- CA057621/CA/NCI NIH HHS/ -- ES012801/ES/NIEHS NIH HHS/ -- R01 CA057621/CA/NCI NIH HHS/ -- R01 CA057621-16A1/CA/NCI NIH HHS/ -- U01 ES012801-06/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 2008 Dec 5;322(5907):1506-9. doi: 10.1126/science.1162783.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anatomy and Program in Developmental Biology, University of California at San Francisco, San Francisco, CA 94143-0452, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19056977" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Vessels/embryology/physiology ; *Body Patterning ; Cell Differentiation ; Epithelium/embryology/physiology ; Genes ; Mesoderm/embryology/physiology ; *Morphogenesis ; Nervous System/embryology ; Neurons/cytology ; *Organogenesis ; Regeneration ; Signal Transduction ; Stem Cells/physiology ; Stromal Cells/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 32
    Publication Date: 2008-02-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉De Waal, Frans B M -- Boesch, Christophe -- Horner, Victoria -- Whiten, Andrew -- New York, N.Y. -- Science. 2008 Feb 1;319(5863):569; author reply 569. doi: 10.1126/science.319.5863.569c.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18239107" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Child, Preschool ; Cues ; *Hominidae ; Humans ; *Learning ; Research Design ; *Social Behavior
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 33
    Publication Date: 2008-06-21
    Description: Astrocytes have long been thought to act as a support network for neurons, with little role in information representation or processing. We used two-photon imaging of calcium signals in the ferret visual cortex in vivo to discover that astrocytes, like neurons, respond to visual stimuli, with distinct spatial receptive fields and sharp tuning to visual stimulus features including orientation and spatial frequency. The stimulus-feature preferences of astrocytes were exquisitely mapped across the cortical surface, in close register with neuronal maps. The spatially restricted stimulus-specific component of the intrinsic hemodynamic mapping signal was highly sensitive to astrocyte activation, indicating that astrocytes have a key role in coupling neuronal organization to mapping signals critical for noninvasive brain imaging. Furthermore, blocking astrocyte glutamate transporters influenced the magnitude and duration of adjacent visually driven neuronal responses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schummers, James -- Yu, Hongbo -- Sur, Mriganka -- New York, N.Y. -- Science. 2008 Jun 20;320(5883):1638-43. doi: 10.1126/science.1156120.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18566287" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aspartic Acid/pharmacology ; Astrocytes/drug effects/*physiology ; Blood Volume ; Brain Mapping ; Calcium/metabolism ; Calcium Signaling ; Cerebrovascular Circulation ; Ferrets ; Fluorescent Dyes ; Glutamic Acid/metabolism ; Male ; Microscopy, Confocal ; Neurons/*physiology ; Neurotransmitter Agents/metabolism ; Photic Stimulation ; Synapses/physiology ; Visual Cortex/blood supply/cytology/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 34
    Publication Date: 2008-02-16
    Description: Weir and Schluter (Reports, 16 March 2007, p. 1574) used variation in the age distribution of sister species to estimate that recent rates of speciation decline toward the tropics. However, this conclusion may be undermined by taxonomic biases, sampling artifacts, and the sister-species method, all of which tend to underestimate diversification rates at low latitudes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tobias, Joseph A -- Bates, John M -- Hackett, Shannon J -- Seddon, Nathalie -- New York, N.Y. -- Science. 2008 Feb 15;319(5865):901; author reply 901. doi: 10.1126/science.1150568.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Edward Grey Institute, Department of Zoology, University of Oxford, Oxford OX1 3PS, UK. joseph.tobias@zoo.ox.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18276872" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biodiversity ; *Birds/classification/genetics ; *Extinction, Biological ; *Genetic Speciation ; Geography ; Haplotypes ; *Mammals/classification/genetics ; *Passeriformes/classification/genetics ; Phylogeny ; Tropical Climate
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 35
    Publication Date: 2008-05-10
    Description: To understand the system of secreted proteins and receptors involved in cell-cell signaling, we produced a comprehensive set of recombinant secreted proteins and the extracellular domains of transmembrane proteins, which constitute most of the protein components of the extracellular space. Each protein was tested in a suite of assays that measured metabolic, growth, or transcriptional responses in diverse cell types. The pattern of responses across assays was analyzed for the degree of functional selectivity of each protein. One of the highly selective proteins was a previously undescribed ligand, designated interleukin-34 (IL-34), which stimulates monocyte viability but does not affect responses in a wide spectrum of other assays. In a separate functional screen, we used a collection of extracellular domains of transmembrane proteins to discover the receptor for IL-34, which was a known cytokine receptor, colony-stimulating factor 1 (also called macrophage colony-stimulating factor) receptor. This systematic approach is thus useful for discovering new ligands and receptors and assessing the functional selectivity of extracellular regulatory proteins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, Haishan -- Lee, Ernestine -- Hestir, Kevin -- Leo, Cindy -- Huang, Minmei -- Bosch, Elizabeth -- Halenbeck, Robert -- Wu, Ge -- Zhou, Aileen -- Behrens, Dirk -- Hollenbaugh, Diane -- Linnemann, Thomas -- Qin, Minmin -- Wong, Justin -- Chu, Keting -- Doberstein, Stephen K -- Williams, Lewis T -- New York, N.Y. -- Science. 2008 May 9;320(5877):807-11. doi: 10.1126/science.1154370.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Five Prime Therapeutics, Inc., 1650 Owens Street, Suite 200, San Francisco, CA 94158, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18467591" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cloning, Molecular ; DNA, Complementary ; Extracellular Space/*chemistry ; Humans ; Interleukins/*isolation & purification/physiology/secretion ; Membrane Proteins/isolation & purification/physiology ; Protein Structure, Tertiary ; Proteome ; Receptors, Interleukin/*isolation & purification/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 36
    Publication Date: 2008-12-17
    Description: Retinoic acid (RA) is an essential extrinsic inducer of meiotic initiation in mammalian germ cells. However, RA acts too widely in mammalian development to account, by itself, for the cell-type and temporal specificity of meiotic initiation. We considered parallels to yeast, in which extrinsic and intrinsic factors combine to restrict meiotic initiation. We demonstrate that, in mouse embryos, extrinsic and intrinsic factors together regulate meiotic initiation. The mouse RNA-binding protein DAZL, which is expressed by postmigratory germ cells, is a key intrinsic factor, enabling those cells to initiate meiosis in response to RA. Within a brief developmental window, Dazl-expressing germ cells in both XX and XY embryos actively acquire the ability to interpret RA as a meiosis-inducing signal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, Yanfeng -- Gill, Mark E -- Koubova, Jana -- Page, David C -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2008 Dec 12;322(5908):1685-7. doi: 10.1126/science.1166340.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19074348" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Proteins, Signal Transducing ; Animals ; Cell Cycle Proteins/metabolism ; Cell Nucleus/ultrastructure ; DNA Breaks ; DNA Repair ; Embryo, Mammalian/*cytology/physiology ; Endodeoxyribonucleases ; Esterases/metabolism ; Female ; Germ Cells/*cytology ; Male ; *Meiosis ; Mice ; Mice, Inbred C57BL ; Nuclear Proteins/genetics/metabolism ; Ovary/embryology/physiology ; Phosphoproteins/genetics/metabolism ; Proteins/metabolism ; RNA-Binding Proteins/genetics/*physiology ; Testis/embryology/physiology ; Tretinoin/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 37
    Publication Date: 2008-11-08
    Description: Gilbert et al. (Reports, 28 September 2007, p. 1927) reported that "hair shafts surpass comparably stored bone as an aDNA source [...] in regard to preservation and concentration of mtDNA." When experimental parameters are carefully controlled for, including adequate sampling, quantitative polymerase chain reaction analysis, and modeling the decay of DNA, the general importance of this claim is not supported.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Debruyne, Regis -- Schwarz, Carsten -- Poinar, Hendrik -- New York, N.Y. -- Science. 2008 Nov 7;322(5903):857; author reply 857. doi: 10.1126/science.1158417.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉McMaster Ancient DNA Centre, Department of Anthropology, McMaster University, 1280 Main Street West, Hamilton L8S 4L9, ON, Canada. debruyne@mcmaster.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18988826" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; DNA Damage ; DNA, Mitochondrial/chemistry/genetics/*history ; Elephants/*genetics ; Genome, Mitochondrial ; *Hair/chemistry ; History, Ancient ; Preservation, Biological ; *Sequence Analysis, DNA
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 38
    Publication Date: 2008-07-26
    Description: Ribonucleoprotein complexes consisting of Argonaute-like proteins and small regulatory RNAs function in a wide range of biological processes. Many of these small regulatory RNAs are predicted to act, at least in part, within the nucleus. We conducted a genetic screen to identify factors essential for RNA interference (RNAi) in nuclei of Caenorhabditis elegans and identified the Argonaute protein NRDE-3. In the absence of small interfering RNAs (siRNAs), NRDE-3 resides in the cytoplasm. NRDE-3 binds siRNAs generated by RNA-dependent RNA polymerases acting on messenger RNA templates in the cytoplasm and redistributes to the nucleus. Nuclear redistribution of NRDE-3 requires a functional nuclear localization signal, is required for nuclear RNAi, and results in NRDE-3 association with nuclear-localized nascent transcripts. Thus, specific Argonaute proteins can transport specific classes of small regulatory RNAs to distinct cellular compartments to regulate gene expression.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771369/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771369/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guang, Shouhong -- Bochner, Aaron F -- Pavelec, Derek M -- Burkhart, Kirk B -- Harding, Sandra -- Lachowiec, Jennifer -- Kennedy, Scott -- R01 GM076619/GM/NIGMS NIH HHS/ -- R01 GM076619-01/GM/NIGMS NIH HHS/ -- R01 GM076619-02/GM/NIGMS NIH HHS/ -- R01 GM076619-03/GM/NIGMS NIH HHS/ -- R01 GM088289/GM/NIGMS NIH HHS/ -- R01 GM088289-01/GM/NIGMS NIH HHS/ -- T32 GM007133/GM/NIGMS NIH HHS/ -- T32 GM007133-24/GM/NIGMS NIH HHS/ -- T32 GM007133-25/GM/NIGMS NIH HHS/ -- T32 GM007133-26/GM/NIGMS NIH HHS/ -- T32 GM007133-27/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2008 Jul 25;321(5888):537-41. doi: 10.1126/science.1157647.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, University of Wisconsin-Madison, Madison, WI 53706, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18653886" target="_blank"〉PubMed〈/a〉
    Keywords: Active Transport, Cell Nucleus ; Animals ; Caenorhabditis elegans/embryology/*genetics/growth & development/*metabolism ; Caenorhabditis elegans Proteins/chemistry/genetics/*metabolism ; Cell Nucleus/*metabolism ; Cytoplasm/*metabolism ; Genes, Helminth ; Mutation ; Nuclear Localization Signals ; Protein Structure, Tertiary ; *RNA Interference ; RNA Precursors/genetics/metabolism ; RNA Replicase/metabolism ; RNA, Double-Stranded/chemistry/genetics/metabolism ; RNA, Helminth/chemistry/genetics/metabolism ; RNA, Messenger/genetics/metabolism ; RNA, Small Interfering/chemistry/genetics/*metabolism ; RNA-Binding Proteins/chemistry/genetics/*metabolism ; Up-Regulation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 39
    Publication Date: 2008-06-07
    Description: In mammals, dosage compensation is achieved by X-chromosome inactivation (XCI) in the female. The noncoding Xist gene initiates silencing of the X chromosome, whereas its antisense partner Tsix blocks silencing. The complementarity of Xist and Tsix RNAs has long suggested a role for RNA interference (RNAi). Here, we report that murine Xist and Tsix form duplexes in vivo. During XCI, the duplexes are processed to small RNAs (sRNAs), most likely on the active X (Xa) in a Dicer-dependent manner. Deleting Dicer compromises sRNA production and derepresses Xist. Furthermore, without Dicer, Xist RNA cannot accumulate and histone 3 lysine 27 trimethylation is blocked on the inactive X (Xi). The defects are partially rescued by truncating Tsix. Thus, XCI and RNAi intersect, down-regulating Xist on Xa and spreading silencing on Xi.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584363/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584363/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ogawa, Yuya -- Sun, Bryan K -- Lee, Jeannie T -- R01 GM058839/GM/NIGMS NIH HHS/ -- R01 GM058839-10/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2008 Jun 6;320(5881):1336-41. doi: 10.1126/science.1157676.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology, Massachusetts General Hospital and Howard Hughes Medical Institute, Boston, MA 02114, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18535243" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; Cells, Cultured ; DEAD-box RNA Helicases/genetics/metabolism ; Embryonic Stem Cells ; Endoribonucleases/genetics/metabolism ; Female ; Histones/metabolism ; Male ; Methylation ; Mice ; *RNA Interference ; RNA, Double-Stranded/metabolism ; RNA, Long Noncoding ; RNA, Small Nuclear/metabolism ; RNA, Untranslated/genetics/*metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Ribonuclease III ; X Chromosome/*genetics/metabolism ; *X Chromosome Inactivation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 40
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-08-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, Robert H Jr -- New York, N.Y. -- Science. 2008 Aug 29;321(5893):1169-70. doi: 10.1126/science.1163475.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Massachusetts General Hospital, 16th Street, Navy Yard, Charlestown, MA 02129, USA. rhbrown@partners.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18755965" target="_blank"〉PubMed〈/a〉
    Keywords: Aged, 80 and over ; Amyotrophic Lateral Sclerosis/enzymology/genetics/*pathology/therapy ; Animals ; *Cell Differentiation ; *Cellular Reprogramming ; Embryonic Stem Cells/cytology ; Female ; Fibroblasts/*cytology ; Humans ; Motor Neurons/*cytology/enzymology/transplantation ; Nervous System Diseases/pathology/therapy ; Neuroglia/cytology ; Pluripotent Stem Cells/*cytology ; Superoxide Dismutase/genetics/metabolism ; Transduction, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 41
    Publication Date: 2008-07-26
    Description: Membrane and secretory proteins cotranslationally enter and are folded in the endoplasmic reticulum (ER). Misfolded or unassembled proteins are discarded by a process known as ER-associated degradation (ERAD), which involves their retrotranslocation into the cytosol. ERAD substrates frequently contain disulfide bonds that must be cleaved before their retrotranslocation. Here, we found that an ER-resident protein ERdj5 had a reductase activity, cleaved the disulfide bonds of misfolded proteins, and accelerated ERAD through its physical and functional associations with EDEM (ER degradation-enhancing alpha-mannosidase-like protein) and an ER-resident chaperone BiP. Thus, ERdj5 is a member of a supramolecular ERAD complex that recognizes and unfolds misfolded proteins for their efficient retrotranslocation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ushioda, Ryo -- Hoseki, Jun -- Araki, Kazutaka -- Jansen, Gregor -- Thomas, David Y -- Nagata, Kazuhiro -- New York, N.Y. -- Science. 2008 Jul 25;321(5888):569-72. doi: 10.1126/science.1159293.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8397, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18653895" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Motifs ; Amino Acid Substitution ; Animals ; Cell Line ; Endoplasmic Reticulum/*metabolism ; Glutathione/metabolism ; HSP40 Heat-Shock Proteins/chemistry/genetics/*metabolism ; Heat-Shock Proteins/metabolism ; Humans ; Immunoglobulin J-Chains/chemistry/metabolism ; Membrane Proteins/metabolism ; Mice ; Molecular Chaperones/chemistry/genetics/*metabolism ; Mutation ; Oxidation-Reduction ; Protein Disulfide Reductase (Glutathione)/metabolism ; Protein Disulfide-Isomerases/metabolism ; Protein Folding ; Protein Structure, Tertiary ; Proteins/chemistry/*metabolism ; Recombinant Proteins/chemistry/metabolism ; Transfection ; Two-Hybrid System Techniques ; alpha 1-Antitrypsin/chemistry/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 42
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-04-26
    Description: At the recent American Association of Physical Anthropology meetings, a researcher described the foot bones of an 18,000-year-old Indonesian skeleton known as the "hobbit." The tiny hominin would not have walked like we do, he said, and may offer "a window into a primitive bipedal foot."〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culotta, Elizabeth -- New York, N.Y. -- Science. 2008 Apr 25;320(5875):433-5. doi: 10.1126/science.320.5875.433.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18436747" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Foot Bones/*anatomy & histology ; Fossils ; Gait ; History, Ancient ; *Hominidae/anatomy & histology/classification/physiology ; Humans ; Indonesia ; Paleodontology ; Paleontology ; Skull/anatomy & histology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 43
    Publication Date: 2008-07-26
    Description: After disappointing results from all efficacy trials conducted to date, the field of microbicides research now faces substantial challenges. Poor coordination among interested parties and the choice of nonvalidated scientific targets for phase III studies have hampered progress and created mistrust about the use of microbicides as a method to prevent HIV-1 sexual transmission. Although new promising strategies are available, there will need to be serious reappraisals of how decisions are made to advance the next generations of candidates into clinical trials, and the use of appropriate animal models in this process will be critical.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835691/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835691/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grant, Robert M -- Hamer, Dean -- Hope, Thomas -- Johnston, Rowena -- Lange, Joep -- Lederman, Michael M -- Lieberman, Judy -- Miller, Christopher J -- Moore, John P -- Mosier, Donald E -- Richman, Douglas D -- Schooley, Robert T -- Springer, Marty S -- Veazey, Ronald S -- Wainberg, Mark A -- U19 AI076981/AI/NIAID NIH HHS/ -- U19 AI076981-01/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2008 Jul 25;321(5888):532-4. doi: 10.1126/science.1160355.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉J. David Gladstone Institutes, University of California-San Francisco, San Francisco, CA 94518, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18653884" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Intravaginal ; Animals ; Anti-HIV Agents/*administration & dosage/pharmacology/therapeutic use ; Anti-Infective Agents, Local/*administration & dosage/pharmacology/therapeutic ; use ; Clinical Trials as Topic ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Drug Therapy, Combination ; Female ; HIV Infections/drug therapy/*prevention & control/transmission ; HIV-1/*drug effects ; Humans ; Male ; Patient Compliance ; Polymers/*administration & dosage/pharmacology/therapeutic use ; Primates ; Reverse Transcriptase Inhibitors/*administration & ; dosage/pharmacology/therapeutic use ; Vaginal Diseases/drug therapy/*prevention & control
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 44
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-10-18
    Description: Positive and negative feedback loops are common regulatory elements in biological signaling systems. We discuss core feedback motifs that have distinct roles in shaping signaling responses in space and time. We also discuss approaches to experimentally investigate feedback loops in signaling systems.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680159/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680159/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brandman, Onn -- Meyer, Tobias -- R01 GM030179/GM/NIGMS NIH HHS/ -- R01 GM030179-25/GM/NIGMS NIH HHS/ -- R01 GM063702/GM/NIGMS NIH HHS/ -- R01 GM063702-06/GM/NIGMS NIH HHS/ -- R01GM030179/GM/NIGMS NIH HHS/ -- R01GM063702/GM/NIGMS NIH HHS/ -- R01MH064801/MH/NIMH NIH HHS/ -- R33 CA120732/CA/NCI NIH HHS/ -- R33 CA120732-02/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2008 Oct 17;322(5900):390-5. doi: 10.1126/science.1160617.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cellular and Molecular Pharmacology, University of California-San Francisco and Howard Hughes Medical Institute, San Francisco, CA 94158, USA. Onn.Brandman@ucsf.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18927383" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/metabolism ; *Calcium Signaling ; Cell Membrane/metabolism ; Chemotaxis, Leukocyte ; Computer Simulation ; Endoplasmic Reticulum/metabolism ; *Feedback, Physiological ; Models, Biological ; Neutrophils/*metabolism/physiology ; Phosphatidylinositol 3-Kinases/*metabolism ; *Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 45
    Publication Date: 2008-09-20
    Description: Understanding cell morphogenesis during metazoan development requires knowledge of how cells and the extracellular matrix produce and respond to forces. We investigated how apoptosis, which remodels tissue by eliminating supernumerary cells, also contributes forces to a tissue (the amnioserosa) that promotes cell-sheet fusion (dorsal closure) in the Drosophila embryo. We showed that expression in the amnioserosa of proteins that suppress or enhance apoptosis slows or speeds dorsal closure, respectively. These changes correlate with the forces produced by the amnioserosa and the rate of seam formation between the cell sheets (zipping), key processes that contribute to closure. This apoptotic force is used by the embryo to drive cell-sheet movements during development, a role not classically attributed to apoptosis.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757114/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757114/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Toyama, Yusuke -- Peralta, Xomalin G -- Wells, Adrienne R -- Kiehart, Daniel P -- Edwards, Glenn S -- GM33830/GM/NIGMS NIH HHS/ -- R01 GM033830/GM/NIGMS NIH HHS/ -- R01 GM033830-24/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2008 Sep 19;321(5896):1683-6. doi: 10.1126/science.1157052.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Physics Department and Free Electron Laser Laboratory, Duke University, Durham, NC 27708, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18802000" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Apoptosis ; Cell Movement ; Cell Shape ; Drosophila melanogaster/cytology/*embryology ; Embryo, Nonmammalian/*cytology ; *Embryonic Development ; Epidermis/cytology/embryology ; Epithelial Cells/*cytology/physiology ; Epithelium/*embryology ; Female ; Microscopy, Confocal ; *Morphogenesis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 46
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-07-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Normile, Dennis -- New York, N.Y. -- Science. 2008 Jul 4;321(5885):26. doi: 10.1126/science.321.5885.26b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18599749" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Japan ; *Research ; *Whales
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 47
    Publication Date: 2008-03-01
    Description: Intraluminal vesicles of multivesicular endosomes are either sorted for cargo degradation into lysosomes or secreted as exosomes into the extracellular milieu. The mechanisms underlying the sorting of membrane into the different populations of intraluminal vesicles are unknown. Here, we find that cargo is segregated into distinct subdomains on the endosomal membrane and that the transfer of exosome-associated domains into the lumen of the endosome did not depend on the function of the ESCRT (endosomal sorting complex required for transport) machinery, but required the sphingolipid ceramide. Purified exosomes were enriched in ceramide, and the release of exosomes was reduced after the inhibition of neutral sphingomyelinases. These results establish a pathway in intraendosomal membrane transport and exosome formation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Trajkovic, Katarina -- Hsu, Chieh -- Chiantia, Salvatore -- Rajendran, Lawrence -- Wenzel, Dirk -- Wieland, Felix -- Schwille, Petra -- Brugger, Britta -- Simons, Mikael -- New York, N.Y. -- Science. 2008 Feb 29;319(5867):1244-7. doi: 10.1126/science.1153124.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Biochemistry and Molecular Cell Biology, University of Gottingen, 37073 Gottingen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18309083" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Line, Tumor ; Ceramides/analysis/*metabolism ; Cytoplasmic Vesicles/chemistry/*metabolism/ultrastructure ; Endosomes/*metabolism/ultrastructure ; Humans ; Intracellular Membranes/*metabolism/ultrastructure ; Membrane Microdomains/*metabolism/ultrastructure ; Mice ; Myelin Proteolipid Protein/*metabolism ; Oligodendroglia/metabolism/ultrastructure ; Protein Transport ; Receptor, Epidermal Growth Factor/metabolism ; Recombinant Fusion Proteins/metabolism ; Sphingomyelin Phosphodiesterase/antagonists & inhibitors/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 48
    Publication Date: 2008-04-19
    Description: Toll-like receptor 3 (TLR3) recognizes double-stranded RNA (dsRNA), a molecular signature of most viruses, and triggers inflammatory responses that prevent viral spread. TLR3 ectodomains (ECDs) dimerize on oligonucleotides of at least 40 to 50 base pairs in length, the minimal length required for signal transduction. To establish the molecular basis for ligand binding and signaling, we determined the crystal structure of a complex between two mouse TLR3-ECDs and dsRNA at 3.4 angstrom resolution. Each TLR3-ECD binds dsRNA at two sites located at opposite ends of the TLR3 horseshoe, and an intermolecular contact between the two TLR3-ECD C-terminal domains coordinates and stabilizes the dimer. This juxtaposition could mediate downstream signaling by dimerizing the cytoplasmic Toll interleukin-1 receptor (TIR) domains. The overall shape of the TLR3-ECD does not change upon binding to dsRNA.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761030/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761030/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, Lin -- Botos, Istvan -- Wang, Yan -- Leonard, Joshua N -- Shiloach, Joseph -- Segal, David M -- Davies, David R -- Z01 BC009254-33/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2008 Apr 18;320(5874):379-81. doi: 10.1126/science.1155406.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18420935" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Binding Sites ; Crystallography, X-Ray ; Dimerization ; Humans ; Ligands ; Mice ; Models, Molecular ; Molecular Sequence Data ; Mutant Proteins/chemistry/genetics/metabolism ; NF-kappa B/metabolism ; Nucleic Acid Conformation ; Protein Conformation ; Protein Structure, Tertiary ; RNA, Double-Stranded/*chemistry/*metabolism ; *Signal Transduction ; Toll-Like Receptor 3/*chemistry/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 49
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-01-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Valiela, Ivan -- Fox, Sophia E -- New York, N.Y. -- Science. 2008 Jan 18;319(5861):290-1. doi: 10.1126/science.1153477.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Ecosystems Center and Boston University Marine Program, Marine Biological Laboratory, Woods Hole, MA 02543, USA. ivaliela@mbl.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18202280" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Conservation of Natural Resources/economics ; Cost-Benefit Analysis ; *Ecosystem ; *Penaeidae ; *Rhizophoraceae ; Thailand ; Trees ; Water Movements ; *Wetlands
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 50
    Publication Date: 2008-10-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Travis, John -- New York, N.Y. -- Science. 2008 Oct 17;322(5900):369. doi: 10.1126/science.322.5900.369.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18927372" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone and Bones/chemistry ; Breeding ; DNA/analysis ; Ecosystem ; Europe ; *Fishes/classification/genetics/physiology ; *Rivers
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 51
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-05-24
    Description: The biogeographic variation of life has predominantly been studied using taxonomy, but this focus is changing. There is a resurging interest in understanding patterns in the distribution not only of taxa but also of the traits those taxa possess. Patterns of trait variation shed light on fundamental questions in biology, including why organisms live where they do and how they will respond to environmental change. Technological advances such as environmental genomics place microbial ecology in a unique position to move trait-based biogeography forward. We anticipate that as trait-based biogeography continues to evolve, micro- and macroorganisms will be studied in concert, establishing a science that is informed by and relevant to all domains of life.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Green, Jessica L -- Bohannan, Brendan J M -- Whitaker, Rachel J -- New York, N.Y. -- Science. 2008 May 23;320(5879):1039-43. doi: 10.1126/science.1153475.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Ecology and Evolutionary Biology, Department of Biology, University of Oregon, Eugene, Oregon 97403, USA. jlgreen@uoregon.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18497288" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Archaea/classification/genetics/metabolism/physiology ; Bacteria/*classification/genetics/metabolism ; *Bacterial Physiological Phenomena ; Biodiversity ; DNA, Ribosomal/genetics ; Ecology ; *Ecosystem ; Environment ; Gene Dosage ; Genes, Bacterial ; Genomics ; Plant Physiological Phenomena
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 52
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-11-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guntheroth, Warren G -- New York, N.Y. -- Science. 2008 Nov 7;322(5903):856-7; author reply 856-7. doi: 10.1126/science.322.5903.856.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18988825" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autonomic Nervous System/metabolism ; Bradycardia ; Disease Models, Animal ; Humans ; Hypothermia ; Infant ; Mice ; Receptors, Serotonin/metabolism ; Serotonin/*metabolism ; Sudden Infant Death/*etiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 53
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-08-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lyon, Bruce E -- Chaine, Alexis S -- Winkler, David W -- New York, N.Y. -- Science. 2008 Aug 22;321(5892):1051-2. doi: 10.1126/science.1159822.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolutionary Biology, University of California, Santa Cruz, CA 95064, USA. lyon@biology.ucsc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18719273" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; *Climate ; Cues ; Environment ; Female ; Male ; *Oviposition ; Passeriformes/genetics/*physiology ; Phenotype ; Photoperiod ; Seasons ; Selection, Genetic ; Temperature ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 54
    Publication Date: 2008-01-05
    Description: We used authentication tests developed for ancient DNA to evaluate claims by Asara et al. (Reports, 13 April 2007, p. 280) of collagen peptide sequences recovered from mastodon and Tyrannosaurus rex fossils. Although the mastodon samples pass these tests, absence of amino acid composition data, lack of evidence for peptide deamidation, and association of alpha1(I) collagen sequences with amphibians rather than birds suggest that T. rex does not.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694913/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694913/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Buckley, Mike -- Walker, Angela -- Ho, Simon Y W -- Yang, Yue -- Smith, Colin -- Ashton, Peter -- Oates, Jane Thomas -- Cappellini, Enrico -- Koon, Hannah -- Penkman, Kirsty -- Elsworth, Ben -- Ashford, Dave -- Solazzo, Caroline -- Andrews, Phillip -- Strahler, John -- Shapiro, Beth -- Ostrom, Peggy -- Gandhi, Hasand -- Miller, Webb -- Raney, Brian -- Zylber, Maria Ines -- Gilbert, M Thomas P -- Prigodich, Richard V -- Ryan, Michael -- Rijsdijk, Kenneth F -- Janoo, Anwar -- Collins, Matthew J -- 076905/Wellcome Trust/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2008 Jan 4;319(5859):33; author reply 33. doi: 10.1126/science.1147046.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉BioArch, Departments of Biology, Archaeology, Chemistry and Technology Facility, University of York, Post Office Box 373, York YO10 5YW, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18174420" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Bone and Bones/*chemistry ; Collagen/*chemistry ; *Dinosaurs ; *Elephants ; *Fossils ; Mass Spectrometry ; Phylogeny
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 55
    Publication Date: 2008-11-01
    Description: Spatial self-organization is the main theoretical explanation for the global occurrence of regular or otherwise coherent spatial patterns in ecosystems. Using mussel beds as a model ecosystem, we provide an experimental demonstration of spatial self-organization. Under homogeneous laboratory conditions, mussels developed regular patterns, similar to those in the field. An individual-based model derived from our experiments showed that interactions between individuals explained the observed patterns. Furthermore, a field study showed that pattern formation affected ecosystem-level processes in terms of improved growth and resistance to wave action. Our results imply that spatial self-organization is an important determinant of the structure and functioning of ecosystems, and it needs to be considered in their conservation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉van de Koppel, Johan -- Gascoigne, Joanna C -- Theraulaz, Guy -- Rietkerk, Max -- Mooij, Wolf M -- Herman, Peter M J -- D18866/Biotechnology and Biological Sciences Research Council/United Kingdom -- New York, N.Y. -- Science. 2008 Oct 31;322(5902):739-42. doi: 10.1126/science.1163952.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Spatial Ecology Department, the Netherlands Institute of Ecology (NIOO-KNAW), Post Office Box 140, 4400 AC Yerseke, Netherlands. J.vandeKoppel@nioo.knaw.nl〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18974353" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomass ; Bivalvia/*physiology ; *Ecosystem ; Models, Biological ; Movement ; Population Dynamics ; Spatial Behavior ; Wales
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 56
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-02-16
    Description: Cadherin-mediated cell adhesion and signaling is essential for metazoan development and yet is absent from all other multicellular organisms. We found cadherin genes at numbers similar to those observed in complex metazoans in one of the closest single-celled relatives of metazoans, the choanoflagellate Monosiga brevicollis. Because the evolution of metazoans from a single-celled ancestor required novel cell adhesion and signaling mechanisms, the discovery of diverse cadherins in choanoflagellates suggests that cadherins may have contributed to metazoan origins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abedin, Monika -- King, Nicole -- New York, N.Y. -- Science. 2008 Feb 15;319(5865):946-8. doi: 10.1126/science.1151084.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cell Biology and Center for Integrative Genomics, University of California at Berkeley, Berkeley, CA 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18276888" target="_blank"〉PubMed〈/a〉
    Keywords: Actin Cytoskeleton/metabolism ; Amino Acid Sequence ; Animals ; Base Sequence ; *Biological Evolution ; Cadherins/*chemistry/*genetics/physiology ; Cell Adhesion ; Ciona intestinalis/chemistry ; Cnidaria/chemistry ; Drosophila melanogaster/chemistry ; Eukaryota/*chemistry ; Eukaryotic Cells/*chemistry/physiology ; Mice ; Molecular Sequence Data ; Protein Structure, Tertiary ; Repetitive Sequences, Amino Acid ; Signal Transduction ; Tyrosine/metabolism ; src Homology Domains
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 57
    Publication Date: 2008-05-20
    Description: The mammalian circadian clockwork is modeled as transcriptional and posttranslational feedback loops, whereby circadian genes are periodically suppressed by their protein products. We show that adenosine 3',5'-monophosphate (cAMP) signaling constitutes an additional, bona fide component of the oscillatory network. cAMP signaling is rhythmic and sustains the transcriptional loop of the suprachiasmatic nucleus, determining canonical pacemaker properties of amplitude, phase, and period. This role is general and is evident in peripheral mammalian tissues and cell lines, which reveals an unanticipated point of circadian regulation in mammals qualitatively different from the existing transcriptional feedback model. We propose that daily activation of cAMP signaling, driven by the transcriptional oscillator, in turn sustains progression of transcriptional rhythms. In this way, clock output constitutes an input to subsequent cycles.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735813/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735813/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Neill, John S -- Maywood, Elizabeth S -- Chesham, Johanna E -- Takahashi, Joseph S -- Hastings, Michael H -- MC_U105170643/Medical Research Council/United Kingdom -- U.1051.02.004(78799)/Medical Research Council/United Kingdom -- Biotechnology and Biological Sciences Research Council/United Kingdom -- Howard Hughes Medical Institute/ -- Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2008 May 16;320(5878):949-53. doi: 10.1126/science.1152506.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Research Council (MRC) Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18487196" target="_blank"〉PubMed〈/a〉
    Keywords: Adenine/analogs & derivatives/pharmacology ; Adenylyl Cyclase Inhibitors ; Adenylyl Cyclases/metabolism ; Animals ; Biological Clocks/genetics/*physiology ; Cell Cycle Proteins/genetics/metabolism ; Circadian Rhythm/drug effects/genetics/*physiology ; Cyclic AMP/*metabolism ; Enzyme Inhibitors/pharmacology ; Feedback, Physiological ; Gene Expression Regulation/drug effects ; Guanine Nucleotide Exchange Factors/metabolism ; Mice ; Mice, Transgenic ; NIH 3T3 Cells ; Nuclear Proteins/genetics/metabolism ; Period Circadian Proteins ; Response Elements ; *Signal Transduction ; Suprachiasmatic Nucleus/drug effects/*metabolism ; Transcription Factors/genetics/metabolism ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 58
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-08-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lyons, Timothy W -- New York, N.Y. -- Science. 2008 Aug 15;321(5891):923-4. doi: 10.1126/science.1162870.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Earth Sciences, University of California, Riverside, CA 92521, USA. timothy.lyons@ucr.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18703731" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atmosphere ; Biological Evolution ; Geologic Sediments/chemistry ; Hydrogen Sulfide/analysis ; Ice Cover ; Iron/*analysis ; Oceans and Seas ; Oxygen/*analysis ; Seawater/*chemistry ; Sulfates/analysis ; Sulfides/analysis ; Time
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 59
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-03-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Normile, Dennis -- New York, N.Y. -- Science. 2008 Mar 21;319(5870):1606-9. doi: 10.1126/science.319.5870.1606.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18356500" target="_blank"〉PubMed〈/a〉
    Keywords: Africa/epidemiology ; Animals ; Asia/epidemiology ; Disease Reservoirs ; Endemic Diseases/prevention & control/veterinary ; Europe ; Immunization Programs ; International Cooperation ; Rinderpest/epidemiology/*prevention & control/virology ; Rinderpest virus/immunology/pathogenicity ; Vaccination/veterinary ; Viral Vaccines/administration & dosage
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 60
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-01-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brecht, Michael -- Schmitz, Dietmar -- New York, N.Y. -- Science. 2008 Jan 4;319(5859):39-40. doi: 10.1126/science.1153231.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Bernstein Center for Computational Neuroscience, Humboldt-University Berlin, 10115 Berlin, Germany. michael.brecht@bccn-berlin.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18174422" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Association Learning ; Calcium/metabolism ; Long-Term Potentiation ; Memory ; Mice ; *Neuronal Plasticity ; Neurons/physiology ; Receptors, Metabotropic Glutamate/metabolism ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/metabolism ; Signal Transduction ; Somatosensory Cortex/cytology/*physiology ; Synapses/*physiology ; Synaptic Membranes/metabolism ; Vibrissae/innervation/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 61
    Publication Date: 2008-03-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Normile, Dennis -- New York, N.Y. -- Science. 2008 Feb 29;319(5867):1178-9. doi: 10.1126/science.319.5867.1178.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18309058" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Birds ; Disease Outbreaks/prevention & control ; Humans ; *Influenza A Virus, H5N1 Subtype/genetics/immunology/pathogenicity ; *Influenza Vaccines ; Influenza in Birds/epidemiology/transmission/*virology ; Influenza, Human/epidemiology/prevention & control/transmission/*virology ; Mutation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 62
    Publication Date: 2008-10-04
    Description: Ceramide engagement in apoptotic pathways has been a topic of controversy. To address this controversy, we tested loss-of-function (lf) mutants of conserved genes of sphingolipid metabolism in Caenorhabditis elegans. Although somatic (developmental) apoptosis was unaffected, ionizing radiation-induced apoptosis of germ cells was obliterated upon inactivation of ceramide synthase and restored upon microinjection of long-chain natural ceramide. Radiation-induced increase in the concentration of ceramide localized to mitochondria and was required for BH3-domain protein EGL-1-mediated displacement of CED-4 (an APAF-1-like protein) from the CED-9 (a Bcl-2 family member)/CED-4 complex, an obligate step in activation of the CED-3 caspase. These studies define CEP-1 (the worm homolog of the tumor suppressor p53)-mediated accumulation of EGL-1 and ceramide synthase-mediated generation of ceramide through parallel pathways that integrate at mitochondrial membranes to regulate stress-induced apoptosis.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585063/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585063/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Deng, Xinzhu -- Yin, Xianglei -- Allan, Richard -- Lu, Diane D -- Maurer, Carine W -- Haimovitz-Friedman, Adriana -- Fuks, Zvi -- Shaham, Shai -- Kolesnick, Richard -- 2R01HD42680-06/HD/NICHD NIH HHS/ -- CA105125-03/CA/NCI NIH HHS/ -- CA85704/CA/NCI NIH HHS/ -- R01 CA085704/CA/NCI NIH HHS/ -- R01 CA085704-09/CA/NCI NIH HHS/ -- R01 HD042680/HD/NICHD NIH HHS/ -- R01 HD042680-07/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2008 Oct 3;322(5898):110-5. doi: 10.1126/science.1158111.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Signal Transduction, Memorial Sloan-Kettering Cancer Center (MSKCC), New York, NY 10021, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18832646" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Apoptosis ; Caenorhabditis elegans/*cytology/genetics/*metabolism/physiology ; Caenorhabditis elegans Proteins/genetics/*metabolism ; Calcium-Binding Proteins/genetics/metabolism ; Ceramides/biosynthesis/*metabolism/pharmacology ; Genes, Helminth ; Germ Cells/*cytology/metabolism/radiation effects ; Mitochondria/metabolism ; Mitochondrial Membranes/metabolism ; Mutation ; Nuclear Envelope/metabolism ; Oxidoreductases/genetics/metabolism ; Proto-Oncogene Proteins c-abl/genetics/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; *Radiation, Ionizing ; Repressor Proteins/metabolism ; Tumor Suppressor Protein p53/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 63
    Publication Date: 2008-07-26
    Description: The Ordovician Period, long considered a supergreenhouse state, saw one of the greatest radiations of life in Earth's history. Previous temperature estimates of up to approximately 70 degrees C have spawned controversial speculation that the oxygen isotopic composition of seawater must have evolved over geological time. We present a very different global climate record determined by ion microprobe oxygen isotope analyses of Early Ordovician-Silurian conodonts. This record shows a steady cooling trend through the Early Ordovician reaching modern equatorial temperatures that were sustained throughout the Middle and Late Ordovician. This favorable climate regime implies not only that the oxygen isotopic composition of Ordovician seawater was similar to that of today, but also that climate played an overarching role in promoting the unprecedented increases in biodiversity that characterized this period.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Trotter, Julie A -- Williams, Ian S -- Barnes, Christopher R -- Lecuyer, Christophe -- Nicoll, Robert S -- New York, N.Y. -- Science. 2008 Jul 25;321(5888):550-4. doi: 10.1126/science.1155814.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Research School of Earth Sciences, Australian National University, Mills Road, Canberra ACT 0200, Australia. julie.trotter@anu.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18653889" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apatites ; *Biodiversity ; *Climate ; *Fossils ; Invertebrates ; Oceans and Seas ; Oxygen Isotopes/analysis ; *Seawater ; Temperature ; *Vertebrates
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 64
    Publication Date: 2008-12-17
    Description: Multiple lines of evidence have shown that the isotopic composition and concentration of calcium in seawater have changed over the past 28 million years. A high-resolution, continuous seawater calcium isotope ratio curve from marine (pelagic) barite reveals distinct features in the evolution of the seawater calcium isotopic ratio suggesting changes in seawater calcium concentrations. The most pronounced increase in the delta44/40Ca value of seawater (of 0.3 per mil) occurred over roughly 4 million years following a period of low values around 13 million years ago. The major change in marine calcium corresponds to a climatic transition and global change in the carbon cycle and suggests a reorganization of the global biogeochemical system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Griffith, Elizabeth M -- Paytan, Adina -- Caldeira, Ken -- Bullen, Thomas D -- Thomas, Ellen -- New York, N.Y. -- Science. 2008 Dec 12;322(5908):1671-4. doi: 10.1126/science.1163614.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Geological and Environmental Sciences, Stanford University, Building 320, Room 118, Stanford, CA 94305, USA. egriffith@ucsc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19074345" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Barium Sulfate/chemistry ; Calcium/*analysis/metabolism ; Calcium Carbonate/analysis ; Calcium Isotopes/analysis ; Climate ; Geologic Sediments/chemistry ; Seawater/*chemistry ; Time
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 65
    Publication Date: 2008-10-11
    Description: Knowledge of mammalian diversity is still surprisingly disparate, both regionally and taxonomically. Here, we present a comprehensive assessment of the conservation status and distribution of the world's mammals. Data, compiled by 1700+ experts, cover all 5487 species, including marine mammals. Global macroecological patterns are very different for land and marine species but suggest common mechanisms driving diversity and endemism across systems. Compared with land species, threat levels are higher among marine mammals, driven by different processes (accidental mortality and pollution, rather than habitat loss), and are spatially distinct (peaking in northern oceans, rather than in Southeast Asia). Marine mammals are also disproportionately poorly known. These data are made freely available to support further scientific developments and conservation action.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schipper, Jan -- Chanson, Janice S -- Chiozza, Federica -- Cox, Neil A -- Hoffmann, Michael -- Katariya, Vineet -- Lamoreux, John -- Rodrigues, Ana S L -- Stuart, Simon N -- Temple, Helen J -- Baillie, Jonathan -- Boitani, Luigi -- Lacher, Thomas E Jr -- Mittermeier, Russell A -- Smith, Andrew T -- Absolon, Daniel -- Aguiar, John M -- Amori, Giovanni -- Bakkour, Noura -- Baldi, Ricardo -- Berridge, Richard J -- Bielby, Jon -- Black, Patricia Ann -- Blanc, J Julian -- Brooks, Thomas M -- Burton, James A -- Butynski, Thomas M -- Catullo, Gianluca -- Chapman, Roselle -- Cokeliss, Zoe -- Collen, Ben -- Conroy, Jim -- Cooke, Justin G -- da Fonseca, Gustavo A B -- Derocher, Andrew E -- Dublin, Holly T -- Duckworth, J W -- Emmons, Louise -- Emslie, Richard H -- Festa-Bianchet, Marco -- Foster, Matt -- Foster, Sabrina -- Garshelis, David L -- Gates, Cormack -- Gimenez-Dixon, Mariano -- Gonzalez, Susana -- Gonzalez-Maya, Jose Fernando -- Good, Tatjana C -- Hammerson, Geoffrey -- Hammond, Philip S -- Happold, David -- Happold, Meredith -- Hare, John -- Harris, Richard B -- Hawkins, Clare E -- Haywood, Mandy -- Heaney, Lawrence R -- Hedges, Simon -- Helgen, Kristofer M -- Hilton-Taylor, Craig -- Hussain, Syed Ainul -- Ishii, Nobuo -- Jefferson, Thomas A -- Jenkins, Richard K B -- Johnston, Charlotte H -- Keith, Mark -- Kingdon, Jonathan -- Knox, David H -- Kovacs, Kit M -- Langhammer, Penny -- Leus, Kristin -- Lewison, Rebecca -- Lichtenstein, Gabriela -- Lowry, Lloyd F -- Macavoy, Zoe -- Mace, Georgina M -- Mallon, David P -- Masi, Monica -- McKnight, Meghan W -- Medellin, Rodrigo A -- Medici, Patricia -- Mills, Gus -- Moehlman, Patricia D -- Molur, Sanjay -- Mora, Arturo -- Nowell, Kristin -- Oates, John F -- Olech, Wanda -- Oliver, William R L -- Oprea, Monik -- Patterson, Bruce D -- Perrin, William F -- Polidoro, Beth A -- Pollock, Caroline -- Powel, Abigail -- Protas, Yelizaveta -- Racey, Paul -- Ragle, Jim -- Ramani, Pavithra -- Rathbun, Galen -- Reeves, Randall R -- Reilly, Stephen B -- Reynolds, John E 3rd -- Rondinini, Carlo -- Rosell-Ambal, Ruth Grace -- Rulli, Monica -- Rylands, Anthony B -- Savini, Simona -- Schank, Cody J -- Sechrest, Wes -- Self-Sullivan, Caryn -- Shoemaker, Alan -- Sillero-Zubiri, Claudio -- De Silva, Naamal -- Smith, David E -- Srinivasulu, Chelmala -- Stephenson, Peter J -- van Strien, Nico -- Talukdar, Bibhab Kumar -- Taylor, Barbara L -- Timmins, Rob -- Tirira, Diego G -- Tognelli, Marcelo F -- Tsytsulina, Katerina -- Veiga, Liza M -- Vie, Jean-Christophe -- Williamson, Elizabeth A -- Wyatt, Sarah A -- Xie, Yan -- Young, Bruce E -- New York, N.Y. -- Science. 2008 Oct 10;322(5899):225-30. doi: 10.1126/science.1165115.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉International Union for Conservation of Nature (IUCN) Species Programme, IUCN, 28 Rue Mauverney, 1196 Gland, Switzerland. jan.schipper@iucn.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18845749" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biodiversity ; Body Size ; Conservation of Natural Resources ; Databases, Factual ; Ecosystem ; *Extinction, Biological ; *Mammals/anatomy & histology/classification/physiology ; Marine Biology ; Phylogeny ; Population Dynamics ; Seawater
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 66
    Publication Date: 2008-03-08
    Description: Chronic hyperglycemia contributes to the development of diabetes-associated complications. Increases in the concentration of circulating glucose activate the hexosamine biosynthetic pathway (HBP) and promote the O-glycosylation of proteins by O-glycosyl transferase (OGT). We show that OGT triggered hepatic gluconeogenesis through the O-glycosylation of the transducer of regulated cyclic adenosine monophosphate response element-binding protein (CREB) 2 (TORC2 or CRTC2). CRTC2 was O-glycosylated at sites that normally sequester CRTC2 in the cytoplasm through a phosphorylation-dependent mechanism. Decreasing amounts of O-glycosylated CRTC2 by expression of the deglycosylating enzyme O-GlcNAcase blocked effects of glucose on gluconeogenesis, demonstrating the importance of the HBP in the development of glucose intolerance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dentin, Renaud -- Hedrick, Susan -- Xie, Jianxin -- Yates, John 3rd -- Montminy, Marc -- R01 GM037828/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2008 Mar 7;319(5868):1402-5. doi: 10.1126/science.1151363.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18323454" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Substitution ; Animals ; Blood Glucose/metabolism ; Cell Nucleus/metabolism ; Cells, Cultured ; Cyclic AMP Response Element-Binding Protein/metabolism ; Cytoplasm/metabolism ; Diabetes Mellitus/metabolism ; *Gluconeogenesis ; Glucose/*metabolism ; Glycosylation ; Glycosyltransferases/metabolism ; Hepatocytes/metabolism ; Humans ; Insulin/metabolism ; Liver/*metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Phosphorylation ; RNA Interference ; Signal Transduction ; Trans-Activators/genetics/*metabolism ; Transcription Factors ; beta-N-Acetylhexosaminidases/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 67
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-12-20
    Description: Nuclear reprogramming describes a switch in gene expression of one kind of cell to that of another unrelated cell type. Early studies in frog cloning provided some of the first experimental evidence for reprogramming. Subsequent procedures included mammalian somatic cell nuclear transfer, cell fusion, induction of pluripotency by ectopic gene expression, and direct reprogramming. Through these methods it becomes possible to derive one kind of specialized cell (such as a brain cell) from another, more accessible, tissue (such as skin) in the same individual. This has potential applications for cell replacement without the immunosuppression treatments that are required when cells are transferred between genetically different individuals. This article provides some background to this field, a discussion of mechanisms and efficiency, and comments on prospects for future nuclear reprogramming research.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gurdon, J B -- Melton, D A -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2008 Dec 19;322(5909):1811-5. doi: 10.1126/science.1160810.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Zoology, University of Cambridge, Cambridge CB2 12N, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19095934" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Dedifferentiation ; Cell Differentiation ; Cell Fusion ; Cell Lineage ; *Cellular Reprogramming ; Cloning, Organism ; DNA/metabolism ; DNA-Binding Proteins/metabolism ; Embryonic Stem Cells/cytology/physiology ; Female ; Gene Expression ; Humans ; Male ; Nuclear Transfer Techniques ; Oocytes/cytology ; Pluripotent Stem Cells/cytology/physiology ; Regulatory Sequences, Nucleic Acid ; Transcription Factors/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 68
    Publication Date: 2008-04-12
    Description: The toxicity of ionizing radiation is associated with massive apoptosis in radiosensitive organs. Here, we investigate whether a drug that activates a signaling mechanism used by tumor cells to suppress apoptosis can protect healthy cells from the harmful effects of radiation. We studied CBLB502, a polypeptide drug derived from Salmonella flagellin that binds to Toll-like receptor 5 (TLR5) and activates nuclear factor-kappaB signaling. A single injection of CBLB502 before lethal total-body irradiation protected mice from both gastrointestinal and hematopoietic acute radiation syndromes and resulted in improved survival. CBLB502 injected after irradiation also enhanced survival, but at lower radiation doses. It is noteworthy that the drug did not decrease tumor radiosensitivity in mouse models. CBLB502 also showed radioprotective activity in lethally irradiated rhesus monkeys. Thus, TLR5 agonists could potentially improve the therapeutic index of cancer radiotherapy and serve as biological protectants in radiation emergencies.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322935/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322935/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burdelya, Lyudmila G -- Krivokrysenko, Vadim I -- Tallant, Thomas C -- Strom, Evguenia -- Gleiberman, Anatoly S -- Gupta, Damodar -- Kurnasov, Oleg V -- Fort, Farrel L -- Osterman, Andrei L -- Didonato, Joseph A -- Feinstein, Elena -- Gudkov, Andrei V -- AI066497/AI/NIAID NIH HHS/ -- CA75179/CA/NCI NIH HHS/ -- CA84406/CA/NCI NIH HHS/ -- R01 CA084406/CA/NCI NIH HHS/ -- R01 CA084406-01A1/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2008 Apr 11;320(5873):226-30. doi: 10.1126/science.1154986.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18403709" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Apoptosis/drug effects/radiation effects ; Chemotherapy, Adjuvant ; Flagellin/chemistry/pharmacology ; Gamma Rays ; Hematopoietic System/drug effects/radiation effects ; Intestine, Small/cytology/drug effects/radiation effects ; Macaca mulatta ; Mice ; Mice, Inbred ICR ; Molecular Sequence Data ; NF-kappa B/*metabolism ; Neoplasms, Experimental/drug therapy/radiotherapy ; Peptides/administration & dosage/chemistry/*pharmacology/toxicity ; Radiation Dosage ; Radiation Injuries, Experimental/*prevention & control ; Radiation Tolerance/*drug effects ; Radiation-Protective Agents/administration & ; dosage/chemistry/*pharmacology/toxicity ; Salmonella enterica ; Signal Transduction ; Toll-Like Receptor 5/*agonists/metabolism ; Whole-Body Irradiation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 69
    Publication Date: 2008-01-05
    Description: The enormous progress made in functional magnetic resonance imaging technology allows us to watch our brains engage in complex cognitive and social tasks. However, our understanding of what actually is computed in the underlying cellular networks is hindered by the vast numbers of neurons involved. Here, we describe a vertebrate system, shaped for top speed, in which a complex and plastic decision is performed by surprisingly small circuitry that can be studied at cellular resolution.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schlegel, Thomas -- Schuster, Stefan -- New York, N.Y. -- Science. 2008 Jan 4;319(5859):104-6. doi: 10.1126/science.1149265.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Universitat Erlangen-Nurnberg Institut fur Zoologie II, Staudtstrasse 5, D-91058 Erlangen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18174445" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Attention ; Cues ; *Decision Making ; Models, Animal ; Nerve Net/*physiology ; Neural Pathways/physiology ; Neurons/*physiology ; Perciformes/*physiology ; Reaction Time
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 70
    Publication Date: 2008-07-05
    Description: A simple negative feedback loop of interacting genes or proteins has the potential to generate sustained oscillations. However, many biological oscillators also have a positive feedback loop, raising the question of what advantages the extra loop imparts. Through computational studies, we show that it is generally difficult to adjust a negative feedback oscillator's frequency without compromising its amplitude, whereas with positive-plus-negative feedback, one can achieve a widely tunable frequency and near-constant amplitude. This tunability makes the latter design suitable for biological rhythms like heartbeats and cell cycles that need to provide a constant output over a range of frequencies. Positive-plus-negative oscillators also appear to be more robust and easier to evolve, rationalizing why they are found in contexts where an adjustable frequency is unimportant.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728800/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728800/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tsai, Tony Yu-Chen -- Choi, Yoon Sup -- Ma, Wenzhe -- Pomerening, Joseph R -- Tang, Chao -- Ferrell, James E Jr -- GM61726/GM/NIGMS NIH HHS/ -- GM77544/GM/NIGMS NIH HHS/ -- R01 GM061276/GM/NIGMS NIH HHS/ -- R01 GM061276-06/GM/NIGMS NIH HHS/ -- R01 GM061276-07/GM/NIGMS NIH HHS/ -- R01 GM061276-08/GM/NIGMS NIH HHS/ -- R01 GM077544/GM/NIGMS NIH HHS/ -- R01 GM077544-01/GM/NIGMS NIH HHS/ -- R01 GM077544-02/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2008 Jul 4;321(5885):126-9. doi: 10.1126/science.1156951.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305-5174, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18599789" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Anaphase-Promoting Complex-Cyclosome ; Animals ; *Biological Clocks ; Biological Evolution ; CDC2 Protein Kinase/*metabolism ; *Cell Cycle ; Cell Division ; Circadian Rhythm ; Cyclin B/biosynthesis/metabolism ; Embryo, Nonmammalian/cytology/metabolism ; *Feedback, Physiological ; Interphase ; Models, Biological ; Monte Carlo Method ; Ubiquitin-Protein Ligase Complexes/metabolism ; Xenopus Proteins/metabolism ; Xenopus laevis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 71
    Publication Date: 2008-12-20
    Description: The repeated discovery of adult dinosaurs in close association with egg clutches leads to speculation over the type and extent of care exhibited by these extinct animals for their eggs and young. To assess parental care in Cretaceous troodontid and oviraptorid dinosaurs, we examined clutch volume and the bone histology of brooding adults. In comparison to four archosaur care regressions, the relatively large clutch volumes of Troodon, Oviraptor, and Citipati scale most closely with a bird-paternal care model. Clutch-associated adults lack the maternal and reproductively associated histologic features common to extant archosaurs. Large clutch volumes and a suite of reproductive features shared only with birds favor paternal care, possibly within a polygamous mating system. Paternal care in both troodontids and oviraptorids indicates that this care system evolved before the emergence of birds and represents birds' ancestral condition. In extant birds and over most adult sizes, paternal and biparental care correspond to the largest and smallest relative clutch volumes, respectively.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Varricchio, David J -- Moore, Jason R -- Erickson, Gregory M -- Norell, Mark A -- Jackson, Frankie D -- Borkowski, John J -- New York, N.Y. -- Science. 2008 Dec 19;322(5909):1826-8. doi: 10.1126/science.1163245.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Earth Sciences, Montana State University, Bozeman, MT 59717, USA. djv@montana.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19095938" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Behavior, Animal ; *Biological Evolution ; *Birds/physiology ; Bone and Bones/anatomy & histology ; Clutch Size ; *Dinosaurs/physiology ; Female ; *Fossils ; Male ; Maternal Behavior ; *Nesting Behavior ; Paternal Behavior ; Regression Analysis ; *Sexual Behavior, Animal
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 72
    Publication Date: 2008-03-08
    Description: We report that developmental competition between sympathetic neurons for survival is critically dependent on a sensitization process initiated by target innervation and mediated by a series of feedback loops. Target-derived nerve growth factor (NGF) promoted expression of its own receptor TrkA in mouse and rat neurons and prolonged TrkA-mediated signals. NGF also controlled expression of brain-derived neurotrophic factor and neurotrophin-4, which, through the receptor p75, can kill neighboring neurons with low retrograde NGF-TrkA signaling whereas neurons with high NGF-TrkA signaling are protected. Perturbation of any of these feedback loops disrupts the dynamics of competition. We suggest that three target-initiated events are essential for rapid and robust competition between neurons: sensitization, paracrine apoptotic signaling, and protection from such effects.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612357/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612357/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Deppmann, Christopher D -- Mihalas, Stefan -- Sharma, Nikhil -- Lonze, Bonnie E -- Niebur, Ernst -- Ginty, David D -- EY016281/EY/NEI NIH HHS/ -- F32 NS053187/NS/NINDS NIH HHS/ -- NS053187/NS/NINDS NIH HHS/ -- NS34814/NS/NINDS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2008 Apr 18;320(5874):369-73. doi: 10.1126/science.1152677. Epub 2008 Mar 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18323418" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Apoptosis ; Brain-Derived Neurotrophic Factor/metabolism ; Cell Survival ; Cells, Cultured ; Computer Simulation ; Feedback, Physiological ; Gene Expression Profiling ; *Gene Expression Regulation, Developmental ; Mathematics ; Mice ; *Models, Neurological ; Nerve Growth Factor/*metabolism ; Nerve Growth Factors/metabolism ; Neurons/cytology/*physiology ; Oligonucleotide Array Sequence Analysis ; Rats ; Receptor, trkA/genetics/*metabolism ; Receptors, Nerve Growth Factor/genetics/metabolism ; Signal Transduction ; Superior Cervical Ganglion/*cytology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 73
    Publication Date: 2008-05-24
    Description: Taguchi et al. (Reports, 20 July 2007, p. 369) reported that mice heterozygous for a null mutation in insulin receptor substrate-2 (Irs2) display a 17% increase in median life span. However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Taguchi et al. were due to atypical life-span profiles in their study animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Selman, Colin -- Lingard, Steven -- Gems, David -- Partridge, Linda -- Withers, Dominic J -- New York, N.Y. -- Science. 2008 May 23;320(5879):1012; author reply 1012. doi: 10.1126/science.1152366.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Diabetes and Endocrinology, Department of Medicine, University College London, Rayne Institute, 5 University Street, London WC1E 6JJ, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18497277" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*metabolism ; Crosses, Genetic ; Diet ; Female ; Homeostasis ; Insulin Receptor Substrate Proteins ; Intracellular Signaling Peptides and Proteins/genetics/*metabolism ; Kaplan-Meier Estimate ; *Longevity ; Male ; Mice ; Mice, Inbred C57BL ; Mutation ; Phosphoproteins/genetics/*metabolism ; Research Design ; Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 74
    Publication Date: 2008-06-28
    Description: Deep avian evolutionary relationships have been difficult to resolve as a result of a putative explosive radiation. Our study examined approximately 32 kilobases of aligned nuclear DNA sequences from 19 independent loci for 169 species, representing all major extant groups, and recovered a robust phylogeny from a genome-wide signal supported by multiple analytical methods. We documented well-supported, previously unrecognized interordinal relationships (such as a sister relationship between passerines and parrots) and corroborated previously contentious groupings (such as flamingos and grebes). Our conclusions challenge current classifications and alter our understanding of trait evolution; for example, some diurnal birds evolved from nocturnal ancestors. Our results provide a valuable resource for phylogenetic and comparative studies in birds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hackett, Shannon J -- Kimball, Rebecca T -- Reddy, Sushma -- Bowie, Rauri C K -- Braun, Edward L -- Braun, Michael J -- Chojnowski, Jena L -- Cox, W Andrew -- Han, Kin-Lan -- Harshman, John -- Huddleston, Christopher J -- Marks, Ben D -- Miglia, Kathleen J -- Moore, William S -- Sheldon, Frederick H -- Steadman, David W -- Witt, Christopher C -- Yuri, Tamaki -- New York, N.Y. -- Science. 2008 Jun 27;320(5884):1763-8. doi: 10.1126/science.1157704.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Zoology Department, Field Museum of Natural History, 1400 South Lake Shore Drive, Chicago, IL 60605, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18583609" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Animals ; Biological Evolution ; Birds/*classification/*genetics ; Ecosystem ; Flight, Animal ; *Genome ; *Genomics ; Molecular Sequence Data ; *Phylogeny ; Sequence Alignment ; Sequence Analysis, DNA
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 75
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-03-15
    Description: Asexual propagation (cloning) is a widespread reproductive strategy of plants and animals. Although larval cloning is well documented in echinoderms, identified stimuli for cloning are limited to those associated with conditions favorable for growth and reproduction. Our research shows that larvae of the sand dollar Dendraster excentricus also clone in response to cues from predators. Predator-induced clones were smaller than uncloned larvae, suggesting an advantage against visual predators. Our results offer another ecological context for asexual reproduction: rapid size reduction as a defense.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vaughn, Dawn -- Strathmann, Richard R -- New York, N.Y. -- Science. 2008 Mar 14;319(5869):1503. doi: 10.1126/science.1151995.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Friday Harbor Laboratories, University of Washington, 620 University Road, Friday Harbor, WA 98250, USA. dvaughn@u.washington.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18339931" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cues ; *Fishes ; Larva/anatomy & histology/physiology ; *Predatory Behavior ; *Reproduction, Asexual ; Sea Urchins/anatomy & histology/growth & development/*physiology ; Zooplankton/cytology/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 76
    Publication Date: 2008-04-26
    Description: McGillicuddy et al. (Reports, 18 May 2007, p. 1021) proposed that eddy/wind interactions enhance the vertical nutrient flux in mode-water eddies, thus feeding large mid-ocean plankton blooms. We argue that the supply of nutrients to ocean eddies is most likely affected by submesoscale processes that act along the periphery of eddies and can induce vertical velocities several times larger than those due to eddy/wind interactions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mahadevan, Amala -- Thomas, Leif N -- Tandon, Amit -- New York, N.Y. -- Science. 2008 Apr 25;320(5875):448; author reply 448. doi: 10.1126/science.1152111.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Earth Sciences, Boston University, Boston, MA 02215, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18436758" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Oceans and Seas ; Phytoplankton/*growth & development ; Plankton/growth & development ; *Seawater ; *Water Movements ; *Wind
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 77
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-03-29
    Description: The gradual modification of transcription circuits over evolutionary time scales is an important source of the diversity of life. Over the past decade, studies in animals have shown how seemingly small molecular changes in gene regulation can have large effects on morphology and physiology and how selective pressures can act on these changes. More recently, genome-wide studies, particularly those in single-cell yeasts, have uncovered evidence of extensive transcriptional rewiring, indicating that even closely related organisms regulate their genes using markedly different circuitries.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tuch, Brian B -- Li, Hao -- Johnson, Alexander D -- New York, N.Y. -- Science. 2008 Mar 28;319(5871):1797-9. doi: 10.1126/science.1152398.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18369141" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; DNA-Binding Proteins ; *Evolution, Molecular ; *Gene Expression Regulation ; *Gene Regulatory Networks ; Humans ; Mutation ; Regulatory Sequences, Nucleic Acid ; Transcription Factors/*metabolism ; *Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 78
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-04-05
    Description: Fundamental to living cells is the capacity to differentiate into subtypes with specialized attributes. Understanding the way cells acquire their fates is a major challenge in developmental biology. How cells adopt a particular fate is usually thought of as being deterministic, and in the large majority of cases it is. That is, cells acquire their fate by virtue of their lineage or their proximity to an inductive signal from another cell. In some cases, however, and in organisms ranging from bacteria to humans, cells choose one or another pathway of differentiation stochastically, without apparent regard to environment or history. Stochasticity has important mechanistic requirements. We speculate on why stochasticity is advantageous-and even critical in some circumstances-to the individual, the colony, or the species.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605794/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605794/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Losick, Richard -- Desplan, Claude -- EY13010/EY/NEI NIH HHS/ -- GM18568/GM/NIGMS NIH HHS/ -- R01 EY013010/EY/NEI NIH HHS/ -- R01 EY013010-11/EY/NEI NIH HHS/ -- R01 GM018568/GM/NIGMS NIH HHS/ -- R01 GM018568-36/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2008 Apr 4;320(5872):65-8. doi: 10.1126/science.1147888.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18388284" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacteria/*cytology ; *Bacterial Physiological Phenomena ; *Cell Differentiation ; Cell Lineage ; *Cell Physiological Phenomena ; Gene Expression Regulation ; Humans ; Stochastic Processes
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 79
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-11-08
    Description: When we are anesthetized, we expect consciousness to vanish. But does it always? Although anesthesia undoubtedly induces unresponsiveness and amnesia, the extent to which it causes unconsciousness is harder to establish. For instance, certain anesthetics act on areas of the brain's cortex near the midline and abolish behavioral responsiveness, but not necessarily consciousness. Unconsciousness is likely to ensue when a complex of brain regions in the posterior parietal area is inactivated. Consciousness vanishes when anesthetics produce functional disconnection in this posterior complex, interrupting cortical communication and causing a loss of integration; or when they lead to bistable, stereotypic responses, causing a loss of information capacity. Thus, anesthetics seem to cause unconsciousness when they block the brain's ability to integrate information.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743249/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743249/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alkire, Michael T -- Hudetz, Anthony G -- Tononi, Giulio -- DP1 OD000579/OD/NIH HHS/ -- DP1 OD000579-01/OD/NIH HHS/ -- DP1 OD000579-02/OD/NIH HHS/ -- DP1 OD000579-03/OD/NIH HHS/ -- DP1 OD000579-04/OD/NIH HHS/ -- R01 GM056398/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2008 Nov 7;322(5903):876-80. doi: 10.1126/science.1149213.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anesthesiology and the Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA 92868, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18988836" target="_blank"〉PubMed〈/a〉
    Keywords: *Anesthesia ; Anesthetics/administration & dosage/*pharmacology ; Animals ; Cerebral Cortex/drug effects/*physiology ; *Consciousness ; Electroencephalography ; Humans ; Memory/drug effects ; *Mental Processes/drug effects/physiology ; Neurons/drug effects/physiology ; Sleep/physiology ; Thalamus/drug effects/*physiology ; *Unconsciousness
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 80
    Publication Date: 2008-10-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dodge, Richard E -- Birkeland, Charles -- Hatziolos, Marea -- Kleypas, Joan -- Palumbi, Stephen R -- Hoegh-Guldberg, Ove -- van Woesik, Rob -- Ogden, John C -- Aronson, Richard B -- Causey, Billy D -- Staub, Francis -- New York, N.Y. -- Science. 2008 Oct 10;322(5899):189-90. doi: 10.1126/science.322.5899.189b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18845729" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Anthozoa ; Carbon Dioxide ; *Conservation of Natural Resources ; *Ecosystem ; Environmental Pollution ; Fisheries/legislation & jurisprudence ; Public Policy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 81
    Publication Date: 2008-11-08
    Description: The failure of axons to regenerate is a major obstacle for functional recovery after central nervous system (CNS) injury. Removing extracellular inhibitory molecules results in limited axon regeneration in vivo. To test for the role of intrinsic impediments to axon regrowth, we analyzed cell growth control genes using a virus-assisted in vivo conditional knockout approach. Deletion of PTEN (phosphatase and tensin homolog), a negative regulator of the mammalian target of rapamycin (mTOR) pathway, in adult retinal ganglion cells (RGCs) promotes robust axon regeneration after optic nerve injury. In wild-type adult mice, the mTOR activity was suppressed and new protein synthesis was impaired in axotomized RGCs, which may contribute to the regeneration failure. Reactivating this pathway by conditional knockout of tuberous sclerosis complex 1, another negative regulator of the mTOR pathway, also leads to axon regeneration. Thus, our results suggest the manipulation of intrinsic growth control pathways as a therapeutic approach to promote axon regeneration after CNS injury.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652400/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652400/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Park, Kevin Kyungsuk -- Liu, Kai -- Hu, Yang -- Smith, Patrice D -- Wang, Chen -- Cai, Bin -- Xu, Bengang -- Connolly, Lauren -- Kramvis, Ioannis -- Sahin, Mustafa -- He, Zhigang -- R01 NS051788/NS/NINDS NIH HHS/ -- R01 NS051788-04/NS/NINDS NIH HHS/ -- R01 NS058956/NS/NINDS NIH HHS/ -- R01 NS058956-02/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2008 Nov 7;322(5903):963-6. doi: 10.1126/science.1161566.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉F. M. Kirby Neurobiology Center, Children's Hospital, and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18988856" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/*physiology ; Axotomy ; Carrier Proteins/*metabolism ; Cell Survival ; Mice ; Mice, Knockout ; Nerve Crush ; *Nerve Regeneration ; Optic Nerve ; PTEN Phosphohydrolase/genetics/*metabolism ; Phosphotransferases (Alcohol Group Acceptor)/*metabolism ; Protein Biosynthesis ; Retinal Ganglion Cells/metabolism/physiology ; Ribosomal Protein S6/metabolism ; *Signal Transduction ; TOR Serine-Threonine Kinases ; Tumor Suppressor Proteins/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 82
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-07-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Margoliash, Daniel -- Hale, Melina E -- New York, N.Y. -- Science. 2008 Jul 18;321(5887):347-8. doi: 10.1126/science.1161775.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60637, USA. dan@bigbird.uchicago.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18635781" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Batrachoidiformes/*anatomy & histology/physiology ; *Biological Evolution ; Learning ; Motor Neurons/cytology ; Nerve Net/*cytology ; Neurons/*cytology ; Rhombencephalon/cytology ; Spinal Cord/cytology ; Vertebrates/*anatomy & histology/physiology ; *Vocalization, Animal
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 83
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-03-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2008 Mar 14;319(5869):1472. doi: 10.1126/science.319.5869.1472a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18339911" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biomedical Research ; Chytridiomycota/isolation & purification ; Commerce/*legislation & jurisprudence ; *Developmental Biology ; Great Britain ; *Xenopus laevis/microbiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 84
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-05-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Margottini, Laura -- New York, N.Y. -- Science. 2008 May 16;320(5878):861. doi: 10.1126/science.320.5878.861a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18487165" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Financing, Government ; Italy ; *Peer Review, Research/legislation & jurisprudence ; *Research Support as Topic ; *Stem Cells
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 85
    Publication Date: 2008-02-16
    Description: The management and conservation of the world's oceans require synthesis of spatial data on the distribution and intensity of human activities and the overlap of their impacts on marine ecosystems. We developed an ecosystem-specific, multiscale spatial model to synthesize 17 global data sets of anthropogenic drivers of ecological change for 20 marine ecosystems. Our analysis indicates that no area is unaffected by human influence and that a large fraction (41%) is strongly affected by multiple drivers. However, large areas of relatively little human impact remain, particularly near the poles. The analytical process and resulting maps provide flexible tools for regional and global efforts to allocate conservation resources; to implement ecosystem-based management; and to inform marine spatial planning, education, and basic research.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Halpern, Benjamin S -- Walbridge, Shaun -- Selkoe, Kimberly A -- Kappel, Carrie V -- Micheli, Fiorenza -- D'Agrosa, Caterina -- Bruno, John F -- Casey, Kenneth S -- Ebert, Colin -- Fox, Helen E -- Fujita, Rod -- Heinemann, Dennis -- Lenihan, Hunter S -- Madin, Elizabeth M P -- Perry, Matthew T -- Selig, Elizabeth R -- Spalding, Mark -- Steneck, Robert -- Watson, Reg -- New York, N.Y. -- Science. 2008 Feb 15;319(5865):948-52. doi: 10.1126/science.1149345.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Center for Ecological Analysis and Synthesis, 735 State Street, Santa Barbara, CA 93101, USA. halpern@nceas.ucsb.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18276889" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Climate ; Conservation of Natural Resources ; *Ecosystem ; Fisheries ; *Human Activities ; Humans ; Mathematics ; Models, Theoretical ; Oceans and Seas
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 86
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-10-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hartzell, H Criss -- R01 EY014852/EY/NEI NIH HHS/ -- R01 EY014852-08/EY/NEI NIH HHS/ -- R01 GM060448/GM/NIGMS NIH HHS/ -- R01 GM060448-08/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2008 Oct 24;322(5901):534-5. doi: 10.1126/science.1165668.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA. criss.hartzell@emory.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18948525" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bronchi/cytology/*metabolism ; Calcium/metabolism ; Cell Division ; Cell Membrane/metabolism ; Chloride Channels/genetics/*metabolism ; Computational Biology ; Epithelial Cells/*metabolism ; Humans ; Interleukin-4/metabolism ; Membrane Proteins/genetics/*metabolism ; Mutation ; Neoplasm Proteins/genetics/*metabolism ; Neoplasms/metabolism ; Oligonucleotide Array Sequence Analysis ; RNA Interference
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 87
    Publication Date: 2008-04-12
    Description: The inhalation of airborne pollutants, such as asbestos or silica, is linked to inflammation of the lung, fibrosis, and lung cancer. How the presence of pathogenic dust is recognized and how chronic inflammatory diseases are triggered are poorly understood. Here, we show that asbestos and silica are sensed by the Nalp3 inflammasome, whose subsequent activation leads to interleukin-1beta secretion. Inflammasome activation is triggered by reactive oxygen species, which are generated by a NADPH oxidase upon particle phagocytosis. (NADPH is the reduced form of nicotinamide adenine dinucleotide phosphate.) In a model of asbestos inhalation, Nalp3-/- mice showed diminished recruitment of inflammatory cells to the lungs, paralleled by lower cytokine production. Our findings implicate the Nalp3 inflammasome in particulate matter-related pulmonary diseases and support its role as a major proinflammatory "danger" receptor.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396588/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396588/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dostert, Catherine -- Petrilli, Virginie -- Van Bruggen, Robin -- Steele, Chad -- Mossman, Brooke T -- Tschopp, Jurg -- P01 CA114047/CA/NCI NIH HHS/ -- P01 CA114047-01A10002/CA/NCI NIH HHS/ -- P01HL67004/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2008 May 2;320(5876):674-7. doi: 10.1126/science.1156995. Epub 2008 Apr 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18403674" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Asbestos/*immunology ; Carrier Proteins/*physiology ; Humans ; Immunity ; Inflammation/*immunology ; Inflammation Mediators/*physiology ; Interleukin-1beta/secretion ; Macrophages/immunology/secretion ; Mice ; Silicon Dioxide/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 88
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-11-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kim, Woo-Yang -- Snider, William D -- New York, N.Y. -- Science. 2008 Nov 7;322(5903):869-72. doi: 10.1126/science.1166152.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Neuroscience Center, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18988832" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/*physiology ; Carrier Proteins/metabolism ; Cell Survival ; Central Nervous System/*cytology ; Cerebellum/cytology ; Genes, p53 ; Humans ; Membrane Glycoproteins/genetics/metabolism ; Mice ; Myelin Proteins/*metabolism ; Nerve Crush ; *Nerve Regeneration ; Neurons/*physiology ; PTEN Phosphohydrolase/genetics ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Receptors, Immunologic/genetics/metabolism ; Retinal Ganglion Cells/cytology ; *Signal Transduction ; Spinal Cord Injuries/therapy ; TOR Serine-Threonine Kinases
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 89
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-08-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- Holden, Constance -- New York, N.Y. -- Science. 2008 Aug 8;321(5890):756-7. doi: 10.1126/science.321.5890.756b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18687929" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bioethical Issues ; *Cell Line ; Consent Forms/*ethics ; Embryo Research/economics/*ethics ; *Embryonic Stem Cells ; Financing, Government ; Humans ; National Institutes of Health (U.S.)/economics ; Pluripotent Stem Cells ; Research Support as Topic ; Tissue Donors/ethics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 90
    Publication Date: 2008-09-06
    Description: A long-standing conjecture in neuroscience is that aspects of cognition depend on the brain's ability to self-generate sequential neuronal activity. We found that reliably and continually changing cell assemblies in the rat hippocampus appeared not only during spatial navigation but also in the absence of changing environmental or body-derived inputs. During the delay period of a memory task, each moment in time was characterized by the activity of a particular assembly of neurons. Identical initial conditions triggered a similar assembly sequence, whereas different conditions gave rise to different sequences, thereby predicting behavioral choices, including errors. Such sequences were not formed in control (nonmemory) tasks. We hypothesize that neuronal representations, evolved for encoding distance in spatial navigation, also support episodic recall and the planning of action sequences.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570043/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570043/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pastalkova, Eva -- Itskov, Vladimir -- Amarasingham, Asohan -- Buzsaki, Gyorgy -- MH54671/MH/NIMH NIH HHS/ -- NS34994/NS/NINDS NIH HHS/ -- R01 MH054671/MH/NIMH NIH HHS/ -- R01 MH054671-10/MH/NIMH NIH HHS/ -- R01 NS034994/NS/NINDS NIH HHS/ -- R01 NS034994-11/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2008 Sep 5;321(5894):1322-7. doi: 10.1126/science.1159775.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Molecular and Behavioral Neuroscience, Rutgers, State University of New Jersey, 197 University Avenue, Newark, NJ 07102, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18772431" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Behavior, Animal ; Choice Behavior ; Cues ; Hippocampus/*cytology/*physiology ; Interneurons/physiology ; Male ; Maze Learning ; *Memory ; *Mental Recall ; Models, Neurological ; Motor Activity ; Pyramidal Cells/*physiology ; Rats ; Rats, Long-Evans
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 91
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-09-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Service, Robert F -- New York, N.Y. -- Science. 2008 Sep 26;321(5897):1758-61. doi: 10.1126/science.321.5897.1758.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18818332" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies ; Blood Proteins/analysis ; Costs and Cost Analysis ; Databases, Protein ; Humans ; International Cooperation ; Mass Spectrometry ; Protein Interaction Mapping ; Proteins/analysis/immunology/metabolism ; Proteome/*analysis ; *Proteomics/economics/instrumentation/methods/standards ; Software
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 92
    Publication Date: 2008-07-05
    Description: It has previously been thought that there was a steep Cretaceous and Cenozoic radiation of marine invertebrates. This pattern can be replicated with a new data set of fossil occurrences representing 3.5 million specimens, but only when older analytical protocols are used. Moreover, analyses that employ sampling standardization and more robust counting methods show a modest rise in diversity with no clear trend after the mid-Cretaceous. Globally, locally, and at both high and low latitudes, diversity was less than twice as high in the Neogene as in the mid-Paleozoic. The ratio of global to local richness has changed little, and a latitudinal diversity gradient was present in the early Paleozoic.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alroy, John -- Aberhan, Martin -- Bottjer, David J -- Foote, Michael -- Fursich, Franz T -- Harries, Peter J -- Hendy, Austin J W -- Holland, Steven M -- Ivany, Linda C -- Kiessling, Wolfgang -- Kosnik, Matthew A -- Marshall, Charles R -- McGowan, Alistair J -- Miller, Arnold I -- Olszewski, Thomas D -- Patzkowsky, Mark E -- Peters, Shanan E -- Villier, Loic -- Wagner, Peter J -- Bonuso, Nicole -- Borkow, Philip S -- Brenneis, Benjamin -- Clapham, Matthew E -- Fall, Leigh M -- Ferguson, Chad A -- Hanson, Victoria L -- Krug, Andrew Z -- Layou, Karen M -- Leckey, Erin H -- Nurnberg, Sabine -- Powers, Catherine M -- Sessa, Jocelyn A -- Simpson, Carl -- Tomasovych, Adam -- Visaggi, Christy C -- New York, N.Y. -- Science. 2008 Jul 4;321(5885):97-100. doi: 10.1126/science.1156963.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Center for Ecological Analysis and Synthesis, University of California-Santa Barbara, 735 State Street, Santa Barbara, CA 93101, USA. alroy@nceas.ucsb.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18599780" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biodiversity ; Biological Evolution ; Databases, Factual ; Environment ; *Fossils ; Geography ; Geologic Sediments ; *Invertebrates/classification ; *Paleontology/methods ; Population Dynamics ; Sampling Studies ; Seawater ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 93
    Publication Date: 2008-08-02
    Description: MyD88 is a key downstream adapter for most Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). MyD88 deficiency in mice leads to susceptibility to a broad range of pathogens in experimental settings of infection. We describe a distinct situation in a natural setting of human infection. Nine children with autosomal recessive MyD88 deficiency suffered from life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease. However, these patients were otherwise healthy, with normal resistance to other microbes. Their clinical status improved with age, but not due to any cellular leakiness in MyD88 deficiency. The MyD88-dependent TLRs and IL-1Rs are therefore essential for protective immunity to a small number of pyogenic bacteria, but redundant for host defense to most natural infections.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688396/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688396/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉von Bernuth, Horst -- Picard, Capucine -- Jin, Zhongbo -- Pankla, Rungnapa -- Xiao, Hui -- Ku, Cheng-Lung -- Chrabieh, Maya -- Mustapha, Imen Ben -- Ghandil, Pegah -- Camcioglu, Yildiz -- Vasconcelos, Julia -- Sirvent, Nicolas -- Guedes, Margarida -- Vitor, Artur Bonito -- Herrero-Mata, Maria Jose -- Arostegui, Juan Ignacio -- Rodrigo, Carlos -- Alsina, Laia -- Ruiz-Ortiz, Estibaliz -- Juan, Manel -- Fortuny, Claudia -- Yague, Jordi -- Anton, Jordi -- Pascal, Mariona -- Chang, Huey-Hsuan -- Janniere, Lucile -- Rose, Yoann -- Garty, Ben-Zion -- Chapel, Helen -- Issekutz, Andrew -- Marodi, Laszlo -- Rodriguez-Gallego, Carlos -- Banchereau, Jacques -- Abel, Laurent -- Li, Xiaoxia -- Chaussabel, Damien -- Puel, Anne -- Casanova, Jean-Laurent -- U19 AI057234/AI/NIAID NIH HHS/ -- U19 AI057234-02/AI/NIAID NIH HHS/ -- U19 AIO57234-02/PHS HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2008 Aug 1;321(5889):691-6. doi: 10.1126/science.1158298.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Human Genetics of Infectious Diseases, INSERM U550, Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18669862" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Animals ; Bacterial Infections/*genetics/*immunology ; Cell Line, Transformed ; Child ; Child, Preschool ; Cytokines/metabolism ; Disease Susceptibility ; Female ; Gene Deletion ; Humans ; Immunity, Innate ; Male ; Mice ; Mutation, Missense ; Myeloid Differentiation Factor 88/*deficiency/genetics/metabolism ; Pneumococcal Infections/genetics/immunology ; Pseudomonas Infections/genetics/immunology ; Receptors, Interleukin-1/immunology/metabolism ; Signal Transduction ; Staphylococcal Infections/genetics/immunology ; Toll-Like Receptors/immunology/metabolism ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 94
    Publication Date: 2008-01-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Doyle, Martin W -- Stanley, Emily H -- Havlick, David G -- Kaiser, Mark J -- Steinbach, George -- Graf, William L -- Galloway, Gerald E -- Riggsbee, J Adam -- New York, N.Y. -- Science. 2008 Jan 18;319(5861):286-7. doi: 10.1126/science.1149852.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of North Carolina at Chapel Hill, NC 27599, USA. mwdoyle@email.unc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18202277" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Ecology ; *Ecosystem ; Public Policy ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 95
    Publication Date: 2008-02-09
    Description: Mouse CD4+CD8+ double-positive (DP) thymocytes differentiate into CD4+ helper-lineage cells upon expression of the transcription factor Th-POK but commit to the CD8+ cytotoxic lineage in its absence. We report the redirected differentiation of class I-restricted thymocytes into CD4+CD8- helper-like T cells upon loss of Runx transcription factor complexes. A Runx-binding sequence within the Th-POK locus acts as a transcriptional silencer that is essential for Th-POK repression and for development of CD8+ T cells. Thus, Th-POK expression and genetic programming for T helper cell development are actively inhibited by Runx-dependent silencer activity, allowing for cytotoxic T cell differentiation. Identification of the transcription factors network in CD4 and CD8 lineage choice provides insight into how distinct T cell subsets are developed for regulating the adaptive immune system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Setoguchi, Ruka -- Tachibana, Masashi -- Naoe, Yoshinori -- Muroi, Sawako -- Akiyama, Kaori -- Tezuka, Chieko -- Okuda, Tsukasa -- Taniuchi, Ichiro -- New York, N.Y. -- Science. 2008 Feb 8;319(5864):822-5. doi: 10.1126/science.1151844.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18258917" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; Cell Lineage ; Chromatin Immunoprecipitation ; Core Binding Factor Alpha 2 Subunit/genetics/*physiology ; Core Binding Factor Alpha 3 Subunit/genetics/*physiology ; Core Binding Factor beta Subunit/metabolism ; Histocompatibility Antigens Class I/immunology ; Histocompatibility Antigens Class II/immunology ; Mice ; Mice, Transgenic ; Molecular Sequence Data ; Silencer Elements, Transcriptional ; T-Lymphocyte Subsets/cytology/*immunology/metabolism ; T-Lymphocytes, Cytotoxic/cytology/*immunology/metabolism ; T-Lymphocytes, Helper-Inducer/cytology/immunology/metabolism ; Transcription Factors/genetics/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 96
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-07-05
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2590634/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2590634/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hasselmo, Michael E -- DA16454/DA/NIDA NIH HHS/ -- MH60013/MH/NIMH NIH HHS/ -- MH60450/MH/NIMH NIH HHS/ -- MH61492/MH/NIMH NIH HHS/ -- MH71702/MH/NIMH NIH HHS/ -- P50 MH060450/MH/NIMH NIH HHS/ -- P50 MH060450-069002/MH/NIMH NIH HHS/ -- P50 MH060450-099002/MH/NIMH NIH HHS/ -- P50 MH071702/MH/NIMH NIH HHS/ -- P50 MH071702-030004/MH/NIMH NIH HHS/ -- R01 DA016454/DA/NIDA NIH HHS/ -- R01 DA016454-05/DA/NIDA NIH HHS/ -- R01 MH060013/MH/NIMH NIH HHS/ -- R01 MH060013-09/MH/NIMH NIH HHS/ -- R01 MH061492/MH/NIMH NIH HHS/ -- R01 MH061492-06A2/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2008 Jul 4;321(5885):46-7. doi: 10.1126/science.1160121.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Memory and Brain, Department of Psychology and Program in Neuroscience, Boston University, Boston, MA 02215, USA. hasselmo@bu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18599761" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Mapping ; Entorhinal Cortex/physiology ; Hippocampus/*cytology/*physiology ; Learning ; Membrane Potentials ; Models, Neurological ; Neurons/*physiology ; Rats ; *Space Perception ; Spatial Behavior
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 97
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-11-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hauser, Marc D -- Bever, Thomas -- New York, N.Y. -- Science. 2008 Nov 14;322(5904):1057-9. doi: 10.1126/science.1167437.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, Human Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA. mdh@wjh.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19008433" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Communication ; Animals ; Biological Evolution ; Brain/*physiology ; Forkhead Transcription Factors/genetics ; Functional Laterality ; Genomics ; Humans ; *Language ; Language Disorders/genetics/physiopathology ; *Linguistics ; Semantics ; Vocabulary
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 98
    Publication Date: 2008-12-17
    Description: Dynein motors move various cargos along microtubules within the cytoplasm and power the beating of cilia and flagella. An unusual feature of dynein is that its microtubule-binding domain (MTBD) is separated from its ring-shaped AAA+ adenosine triphosphatase (ATPase) domain by a 15-nanometer coiled-coil stalk. We report the crystal structure of the mouse cytoplasmic dynein MTBD and a portion of the coiled coil, which supports a mechanism by which the ATPase domain and MTBD may communicate through a shift in the heptad registry of the coiled coil. Surprisingly, functional data suggest that the MTBD, and not the ATPase domain, is the main determinant of the direction of dynein motility.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663340/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663340/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carter, Andrew P -- Garbarino, Joan E -- Wilson-Kubalek, Elizabeth M -- Shipley, Wesley E -- Cho, Carol -- Milligan, Ronald A -- Vale, Ronald D -- Gibbons, I R -- GM30401-29/GM/NIGMS NIH HHS/ -- GM52468/GM/NIGMS NIH HHS/ -- P01 AR042895/AR/NIAMS NIH HHS/ -- P01 AR042895-15/AR/NIAMS NIH HHS/ -- P01-AR42895/AR/NIAMS NIH HHS/ -- P41 RR-17573/RR/NCRR NIH HHS/ -- R01 GM097312/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2008 Dec 12;322(5908):1691-5. doi: 10.1126/science.1164424.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19074350" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Amino Acid Sequence ; Animals ; Binding Sites ; Crystallization ; Crystallography, X-Ray ; Dimerization ; Dyneins/*chemistry/*metabolism ; Hydrophobic and Hydrophilic Interactions ; Image Processing, Computer-Assisted ; Mice ; Microscopy, Electron ; Microtubules/*metabolism/ultrastructure ; Models, Molecular ; Molecular Sequence Data ; Movement ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Recombinant Fusion Proteins/chemistry/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 99
    Publication Date: 2008-01-19
    Description: The earliest step in creating the cerebral cortex is the specification of neuroepithelium to a cortical fate. Using mouse genetic mosaics and timed inactivations, we demonstrated that Lhx2 acts as a classic selector gene and essential intrinsic determinant of cortical identity. Lhx2 selector activity is restricted to an early critical period when stem cells comprise the cortical neuroepithelium, where it acts cell-autonomously to specify cortical identity and suppress alternative fates in a spatially dependent manner. Laterally, Lhx2 null cells adopt antihem identity, whereas medially they become cortical hem cells, which can induce and organize ectopic hippocampal fields. In addition to providing functional evidence for Lhx2 selector activity, these findings show that the cortical hem is a hippocampal organizer.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494603/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494603/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mangale, Vishakha S -- Hirokawa, Karla E -- Satyaki, Prasad R V -- Gokulchandran, Nandini -- Chikbire, Satyadeep -- Subramanian, Lakshmi -- Shetty, Ashwin S -- Martynoga, Ben -- Paul, Jolly -- Mai, Mark V -- Li, Yuqing -- Flanagan, Lisa A -- Tole, Shubha -- Monuki, Edwin S -- 056684/Z/99/Z/Wellcome Trust/United Kingdom -- AG23583/AG/NIA NIH HHS/ -- MH02029/MH/NIMH NIH HHS/ -- NS053511/NS/NINDS NIH HHS/ -- NS07444/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2008 Jan 18;319(5861):304-9. doi: 10.1126/science.1151695.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18202285" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Aggregation ; Cerebral Cortex/cytology/*embryology/metabolism ; Chimera ; Dentate Gyrus/cytology/embryology/metabolism ; Embryonic Induction ; Embryonic Stem Cells/metabolism ; Epithelium/embryology/metabolism ; Gene Expression Regulation, Developmental ; Hippocampus/cytology/*embryology ; Homeodomain Proteins/*genetics/*metabolism ; LIM-Homeodomain Proteins ; Mice ; Mice, Knockout ; Mutation ; Neuroepithelial Cells/cytology/metabolism ; Organizers, Embryonic/embryology/*physiology ; Prosencephalon/embryology/metabolism ; Pyramidal Cells/cytology/embryology ; Recombination, Genetic ; Telencephalon/cytology/embryology ; Transcription Factors/*genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 100
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-09-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Payne, David J -- New York, N.Y. -- Science. 2008 Sep 19;321(5896):1644-5. doi: 10.1126/science.1164586.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Antibacterial Disease Performance Unit, Infectious Diseases Center of Excellence, GlaxoSmithKline, Collegeville, PA 19426, USA. david.j.payne@gsk.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18801989" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-Bacterial Agents/metabolism/*pharmacology/therapeutic use ; Bacteria/*drug effects/genetics/metabolism ; Bacterial Infections/*drug therapy/prevention & control ; Bacterial Proteins/*antagonists & inhibitors/metabolism ; Cytoskeletal Proteins/*antagonists & inhibitors/metabolism ; Drug Design ; Drug Resistance, Bacterial ; Escherichia coli Proteins/*antagonists & inhibitors/metabolism ; Gene Expression Regulation, Bacterial/drug effects ; Humans ; Protein Kinase Inhibitors/pharmacology ; Protein Kinases/*metabolism ; Pyridines/metabolism/*pharmacology ; Sulfonamides/pharmacology/therapeutic use ; Thiazoles/metabolism/*pharmacology ; Virulence/genetics ; Virulence Factors/antagonists & inhibitors/metabolism ; Vitamin K 2/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...