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  • 1
    Publication Date: 1991-12-20
    Description: Transient activation of the interleukin-2 (IL-2) gene after antigen recognition by T lymphocytes is crucial for subsequent T cell proliferation and differentiation. Several IL-2 gene regulatory elements and binding factors necessary for activation of the IL-2 gene have been defined. However, little is known about negative regulation of IL-2 expression, which is likely to be important in the rapid shut-off of IL-2 transcription. A nucleotide sequence element (NRE-A) that negatively regulates IL-2 expression has been identified within the IL-2 gene. T cell nuclear extracts contained an NRE-A binding activity. A complementary DNA was isolated that encodes a zinc finger-containing protein that suppressed IL-2 gene expression. The observation of negative regulation of the immunoglobulin heavy chain gene enhancer by an element similar to NRE-A suggests that related proteins may regulate multiple immune response genes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Williams, T M -- Moolten, D -- Burlein, J -- Romano, J -- Bhaerman, R -- Godillot, A -- Mellon, M -- Rauscher, F J 3rd -- Kant, J A -- AI23879/AI/NIAID NIH HHS/ -- CA23413/CA/NCI NIH HHS/ -- CA54428/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1991 Dec 20;254(5039):1791-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, School of Medicine, University of New Mexico, Albuquerque 87131.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1840704" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Cell Line ; DNA Probes ; *Enhancer Elements, Genetic ; *Gene Expression Regulation ; *Genes, Immunoglobulin ; Humans ; Immunoglobulin Heavy Chains/*genetics ; Interleukin-2/*genetics ; Mice ; Molecular Sequence Data ; Oligodeoxyribonucleotides ; Regulatory Sequences, Nucleic Acid ; Restriction Mapping ; T-Lymphocytes/*immunology ; *Transcription, Genetic ; Zinc Fingers/*genetics/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-10-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mellon, M -- New York, N.Y. -- Science. 1990 Oct 19;250(4979):359-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2218538" target="_blank"〉PubMed〈/a〉
    Keywords: *Biotechnology ; Eosinophilia/chemically induced ; Genetic Engineering ; Humans ; Tryptophan/*adverse effects ; United States ; *United States Food and Drug Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2008-09-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldburg, Rebecca -- Roach, Steven -- Wallinga, David -- Mellon, Margaret -- New York, N.Y. -- Science. 2008 Sep 5;321(5894):1294. doi: 10.1126/science.321.5894.1294a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18772415" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture ; *Animal Husbandry ; Animals ; Animals, Domestic/*microbiology ; Anti-Bacterial Agents/*administration & dosage ; Drug Utilization ; Humans ; Methicillin Resistance ; Staphylococcal Infections/epidemiology/transmission/veterinary ; Staphylococcus aureus/drug effects/*isolation & purification ; Swine/microbiology ; Swine Diseases/epidemiology/microbiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2014-07-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mellon, Margaret -- England -- Nature. 2014 Jul 24;511(7510):410. doi: 10.1038/511410d.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Mellon Associates, Washington DC, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25056055" target="_blank"〉PubMed〈/a〉
    Keywords: Glycine/adverse effects/analogs & derivatives/pharmacology ; *Herbicide Resistance ; Herbicides/*adverse effects/pharmacology/*supply & distribution ; Plant Weeds/drug effects ; Triazines/adverse effects/pharmacology ; United States ; Weed Control/*methods
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 5
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1996-11-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mellon, M -- New York, N.Y. -- Science. 1996 Nov 1;274(5288):703a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17735317" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1994-04-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mellon, M -- Rissler, J -- New York, N.Y. -- Science. 1994 Apr 22;264(5158):489-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8160004" target="_blank"〉PubMed〈/a〉
    Keywords: Plant Viruses/*genetics ; Plants, Genetically Modified/genetics/*microbiology ; *Recombination, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2010-04-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mellon, Margaret -- New York, N.Y. -- Science. 2010 Apr 9;328(5975):171-2. doi: 10.1126/science.328.5975.171.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20378799" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture/legislation & jurisprudence/methods ; Biotechnology/legislation & jurisprudence ; *Crops, Agricultural/adverse effects ; *Food, Genetically Modified/adverse effects ; Government Regulation ; United States ; United States Food and Drug Administration/legislation & jurisprudence
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2011-02-05
    Description: Despite radically different environmental conditions, terrestrial and martian dunes bear a strong resemblance, indicating that the basic processes of saltation and grainfall (sand avalanching down the dune slipface) operate on both worlds. Here, we show that martian dunes are subject to an additional modification process not found on Earth: springtime sublimation of Mars' CO(2) seasonal polar caps. Numerous dunes in Mars' north polar region have experienced morphological changes within a Mars year, detected in images acquired by the High-Resolution Imaging Science Experiment on the Mars Reconnaissance Orbiter. Dunes show new alcoves, gullies, and dune apron extension. This is followed by remobilization of the fresh deposits by the wind, forming ripples and erasing gullies. The widespread nature of these rapid changes, and the pristine appearance of most dunes in the area, implicates active sand transport in the vast polar erg in Mars' current climate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hansen, C J -- Bourke, M -- Bridges, N T -- Byrne, S -- Colon, C -- Diniega, S -- Dundas, C -- Herkenhoff, K -- McEwen, A -- Mellon, M -- Portyankina, G -- Thomas, N -- New York, N.Y. -- Science. 2011 Feb 4;331(6017):575-8. doi: 10.1126/science.1197636.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Planetary Science Institute, Tucson, AZ 85719, USA. cjhansen@psi.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21292976" target="_blank"〉PubMed〈/a〉
    Keywords: *Carbon Dioxide ; Dry Ice ; Extraterrestrial Environment ; *Mars
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 60 (1938), S. 2607-2610 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 33 (1961), S. 1782-1786 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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