Publication Date:
2008-02-16
Description:
Cadherin-mediated cell adhesion and signaling is essential for metazoan development and yet is absent from all other multicellular organisms. We found cadherin genes at numbers similar to those observed in complex metazoans in one of the closest single-celled relatives of metazoans, the choanoflagellate Monosiga brevicollis. Because the evolution of metazoans from a single-celled ancestor required novel cell adhesion and signaling mechanisms, the discovery of diverse cadherins in choanoflagellates suggests that cadherins may have contributed to metazoan origins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abedin, Monika -- King, Nicole -- New York, N.Y. -- Science. 2008 Feb 15;319(5865):946-8. doi: 10.1126/science.1151084.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cell Biology and Center for Integrative Genomics, University of California at Berkeley, Berkeley, CA 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18276888" target="_blank"〉PubMed〈/a〉
Keywords:
Actin Cytoskeleton/metabolism
;
Amino Acid Sequence
;
Animals
;
Base Sequence
;
*Biological Evolution
;
Cadherins/*chemistry/*genetics/physiology
;
Cell Adhesion
;
Ciona intestinalis/chemistry
;
Cnidaria/chemistry
;
Drosophila melanogaster/chemistry
;
Eukaryota/*chemistry
;
Eukaryotic Cells/*chemistry/physiology
;
Mice
;
Molecular Sequence Data
;
Protein Structure, Tertiary
;
Repetitive Sequences, Amino Acid
;
Signal Transduction
;
Tyrosine/metabolism
;
src Homology Domains
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
