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  • Adult  (149)
  • Rabbits  (90)
  • American Association for the Advancement of Science (AAAS)  (239)
  • Blackwell Publishing Ltd
  • 1980-1984  (239)
  • 1925-1929
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (239)
  • Blackwell Publishing Ltd
  • Springer  (4)
Years
Year
  • 101
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    Consensus--more or less--on the Pap smear (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1980 Aug 8;209(4457):672.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7394525" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Female ; Humans ; Middle Aged ; *National Institutes of Health (U.S.) ; *Papanicolaou Test ; United States ; Uterine Cervical Neoplasms/*diagnosis ; *Vaginal Smears
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 102
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    Women gain parity in smoking-related ailments (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, J R -- New York, N.Y. -- Science. 1980 Feb 1;207(4430):509.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7352257" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Female ; Humans ; Lung Neoplasms/epidemiology/*etiology ; Smoking/*complications
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 103
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    Faster cholinergic REM sleep induction in euthymic patients with primary affective illness (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-04-11
    Description: Arecoline, a cholinergic muscarinic receptor agonist, induced rapid eye movement sleep significantly more rapidly in patients with primary affective illness in remission than in normal control subjects matched for age and sex. These results, and others, suggest that patients with primary affective illness may have a supersensitive cholinergic system both when they are ill and when their symptoms are in clinical remission.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sitaram, N -- Nurnberger, J I Jr -- Gershon, E S -- Gillin, J C -- New York, N.Y. -- Science. 1980 Apr 11;208(4440):200-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7361118" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Affective Symptoms/drug therapy/*physiopathology ; Arecoline/*pharmacology ; Female ; Humans ; Injections, Intravenous ; Male ; Sleep Wake Disorders/physiopathology ; Sleep, REM/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 104
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    Panel asks "when is a person dead"? (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1980 Aug 8;209(4457):669-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7394524" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Brain Death ; Child ; *Death ; Humans ; *Legislation, Medical ; *Religion and Medicine ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 105
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    Anxiety and muscle tension as consequences of caffeine withdrawal (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-09-26
    Description: Regular consumers of caffeine had higher muscle tension after three or more hours of abstinence than low caffeine consumers. This difference was absent after double-blind administration of caffeine citrate or placebo. In a discriminative reaction time test, caffeine treatment improved performance. Among subjects receiving placebo, anxiety was highly correlated with prior caffeine use, suggesting that even a brief abstinence may produce anxiety in the regular user.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉White, B C -- Lincoln, C A -- Pearce, N W -- Reeb, R -- Vaida, C -- AA 03513/AA/NIAAA NIH HHS/ -- HD 05958/HD/NICHD NIH HHS/ -- NS 11618/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1980 Sep 26;209(4464):1547-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7433978" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Anxiety/*etiology ; Caffeine/*pharmacology ; Humans ; Muscle Contraction/*drug effects ; Substance Withdrawal Syndrome/complications/*physiopathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 106
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    Electrophysiological signs of split-second decision-making (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-08
    Description: When young adults detected auditory stimuli at split-second intervals, different components of the event-related brain potentials showed markedly different speeds of recovery. The P3 component (latency 300 to 350 milliseconds) was fully recovered at intervals of less than 1.0 second, while the N1--P2 components (latencies 100 to 180 milliseconds) were markedly attenuated with stimulus repetition even at longer interstimulus intervals. Thus, the N1--P2 recovers much more slowly than a subject's ability to evaluate signals, whereas the P3 appears to be generated at the same high rates as the decision processes with which it is associated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Woods, D L -- Hillyard, S A -- Courchesne, E -- Galambos, R -- New York, N.Y. -- Science. 1980 Feb 8;207(4431):655-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7352278" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Auditory Perception/physiology ; Brain/*physiology ; Cognition/physiology ; Decision Making/*physiology ; Evoked Potentials ; Humans ; Memory/physiology ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 107
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    Carboxyhemoglobin levels in an unstable hemoglobin disorder (Hb Zurich): effect on phenotypic expression (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-18
    Description: The affinity of Hb Zurich for carbon monoxide is approximately 65 times that of normal hemoglobin. The carboxyhemoglobin content in serum from individuals with Hb Zurich ranged from 3.9 to 6.7 percent in nine nonsmokers and from 9.8 to 19.7 percent in six smokers. Rates of hemolysis and hemoglobin denaturation were less in smokers than in nonsmokers, effects that may be secondary to the stabilization of Hb Zurich by carbon monoxide.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zinkham, W H -- Houtchens, R A -- Caughey, W S -- New York, N.Y. -- Science. 1980 Jul 18;209(4454):406-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7384813" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Carboxyhemoglobin/*analysis/genetics ; Child ; Female ; Hematocrit ; Hemoglobins/*analysis ; Hemoglobins, Abnormal/*analysis/genetics ; Humans ; Male ; Middle Aged ; Phenotype ; Smoking
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 108
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    Foot-length asymmetry, sex, and handedness (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1981 Jun 19;212(4501):1416-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233233" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Female ; Foot/*anatomy & histology ; *Functional Laterality ; Humans ; Male ; Sex Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 109
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    Endogenous opiates and stress-induced eating (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Antelman, S M -- Rowland, N -- New York, N.Y. -- Science. 1981 Dec 4;214(4525):1149-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302588" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Endorphins/*physiology ; Feeding Behavior/drug effects/*physiology ; Humans ; Naloxone/pharmacology ; Rats ; Rats, Inbred Strains ; Stress, Psychological/*physiopathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 110
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    Phenomenological space-time: toward an experiential relativity (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-07
    Description: Subjects observing differently scaled environments undergo systematic shifts in the experience of time. The experience of temporal duration is compressed relative to the clock in the same proportion as scale-model environments being observed are compressed relative to the full-sized environment. This research suggests that spatial scale may be a principal mediator in the experience of time.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉DeLong, A J -- RR-07088/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1981 Aug 7;213(4508):681-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256273" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Environment ; Humans ; Time Perception/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 111
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    Metabolic mapping of functional activity in human subjects with the [18F]fluorodeoxyglucose technique (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-08
    Description: The 2-[18F]fluoro-2-deoxy-D-glucose technique was used to measure regional cerebral glucose utilization by human subjects during functional activation. Normal male volunteers subjected to one or more sensory stimuli (tactile, visual, or auditory) exhibited focal increases in glucose metabolism in response to the stimulus. Unilateral visual hemifield stimulation caused the contralateral striate cortex to become more metabolically active than the striate cortex ipsilateral to the stimulated hemifield. Similarly, stroking the fingers and hand of one arm with brush produced an increase in metabolism in the contralateral postcentral gyrus, compared with the homologous ipsilateral region. The auditory stimulus, which consisted of a monaurally presented factual story caused an increase in glucose metabolism in the auditory cortex in the hemisphere contralateral to the stimulated ear. These results demonstrate that the technique is capable of providing functional maps in vivo related to both body region and submodality of sensory information in the human brain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Greenberg, J H -- Reivich, M -- Alavi, A -- Hand, P -- Rosenquist, A -- Rintelmann, W -- Stein, A -- Tusa, R -- Dann, R -- Christman, D -- Fowler, J -- MacGregor, B -- Wolf, A -- NS 10939-08/NS/NINDS NIH HHS/ -- NS 14867-02/NS/NINDS NIH HHS/ -- NS 15380-04/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 May 8;212(4495):678-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6971492" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Auditory Perception/*physiology ; Brain/*metabolism ; *Deoxy Sugars ; *Deoxyglucose/analogs & derivatives/metabolism ; Fluorodeoxyglucose F18 ; Functional Laterality ; Humans ; Male ; Sensation/*physiology ; Tomography, Emission-Computed/*methods ; Visual Perception/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 112
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    Purified reduced nicotinamide adenine dinucleotide: responses to lactate dehydrogenase isozymes from three cell sources (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-01
    Description: Lactate dehydrogenase (LDH, E.C. 1.1.1.27) isozymes from three single-cell sources reacted differently with reduced nicotinamide adenine dinucleotide (NADH) purified to published chromatographic and spectrophotometric specifications and free of inhibitors of LDH, when compared with a commercial preparation of NADH. The activity of LDH-1, purified from rabbit erythrocytes, increased the most with inhibitor-free NADH; the next most stimulated were the LDH isozymes from a control hepatocyte line; but hardly responsive at all were the same isozymes from chemically transformed cells. Thus isozyme composition alone did not account for the range of responses to purified NADH. The commercial preparation of NADH used in these studies contains the Strandjord-Clayson inhibitors, the most potent group identified in NADH preparations relative to LDH activity. The results suggest that specific molecular differences in individual isozymes contribute to the differential response to the Strandjord-Clayson inhibitors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaplan, A E -- Weiss, E R -- Byrne, S T -- El-Torkey, N M -- Margolis, S A -- New York, N.Y. -- Science. 1981 May 1;212(4494):553-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209551" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Transformation, Neoplastic/metabolism ; Erythrocytes/enzymology ; Isoenzymes ; L-Lactate Dehydrogenase/antagonists & inhibitors/*metabolism ; Liver Neoplasms, Experimental/enzymology ; NAD/analysis/*metabolism ; Rabbits ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 113
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    Specific and sensitive radioimmunoassay for 3-methoxy-4-hydroxyphenylethyleneglycol (MOPEG) (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-02-06
    Description: Antibodies that specifically bind the norepinephrine metabolite 3-methoxy-4-hydroxyphenylethyleneglycol (MOPEG) were produced in rabbits after injection of a derivative of MOPEG conjugated with bovine thyroglobulin. A sensitive radioimmunoassay was devised with this antiserum, in which as little as 0.5 nanogram of MOPEG can be accurately measured with a final antibody dilution of 1:180. The antibody appears to be specific for MOPEG, since tritiated MOPEG was not displaced from the antibodies by norepinephrine, epinephrine, dopamine, serotonin, or their major metabolites including MOPEG-sulfate (333 nanograms each).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Keeton, T K -- Krutzsch, H -- Lovenberg, W -- New York, N.Y. -- Science. 1981 Feb 6;211(4482):586-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7455697" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibody Specificity ; Brain/*metabolism ; Brain Mapping ; Glycols/*analysis ; Methoxyhydroxyphenylglycol/*analysis/metabolism ; Rabbits ; *Radioimmunoassay/methods ; Rats ; Thyroglobulin
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 114
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    Serum albumin beads: an injectable, biodegradable system for the sustained release of drugs (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-10
    Description: Biologically active compounds were entrapped in cross-linked serum albumin microbeads. Injection of these drug-impregnated beads into rabbits produced no adverse immunological reactions. Sustained release (20 days) of progesterone was demonstrated in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, T K -- Sokoloski, T D -- Royer, G P -- New York, N.Y. -- Science. 1981 Jul 10;213(4504):233-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6787705" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Delayed-Action Preparations ; Glutaral ; Injections, Intramuscular ; Injections, Subcutaneous ; Kinetics ; Male ; Microscopy, Electron, Scanning ; Norgestrel/administration & dosage ; Progesterone/*administration & dosage/blood ; Rabbits ; Serum Albumin, Bovine/*administration & dosage
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 115
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    Air force challenged on sickle trait policy (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1981 Jan 16;211(4479):257.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7444464" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Aerospace Medicine ; Altitude ; *Anemia, Sickle Cell ; Humans ; Jurisprudence ; Male ; *Military Medicine ; Risk ; *Sickle Cell Trait
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 116
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    The Hmong: dying of culture shock? (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshal, E -- New York, N.Y. -- Science. 1981 May 29;212(4498):1008.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233195" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Cultural Characteristics ; *Culture ; Female ; Humans ; Laos/ethnology ; Male ; Middle Aged ; *Mortality ; Refugees/*psychology ; Stress, Physiological ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 117
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    Regulation of leucine metabolism in man: a stable isotope study (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-04
    Description: Leucine catabolism is regulated by either of the first two degradative steps: (reversible) transamination to the keto acid or subsequent decarboxylation. A method is described to measure rates of leucine transamination, reamination, and keto acid oxidation. The method is applied directly to humans by infusing the nonradioactive tracer, L-[15N,1-13C]leucine. Leucine transamination was found to be operating several times faster than the keto acid decarboxylation and to be of equal magnitude in adult human males under two different dietary conditions, postabsorptive and fed. These results indicate that decarboxylation, not transamination, is the rate-limiting step in normal human leucine metabolism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Matthews, D E -- Bier, D M -- Rennie, M J -- Edwards, R H -- Halliday, D -- Millward, D J -- Clugston, G A -- AM-25994/AM/NIADDK NIH HHS/ -- HD-10667/HD/NICHD NIH HHS/ -- RR-00954/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1981 Dec 4;214(4525):1129-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302583" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Carbon Isotopes ; Humans ; Kinetics ; Leucine/*metabolism ; Male ; Models, Biological ; Nitrogen Isotopes ; Oxidation-Reduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 118
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    Assessment of pharmacological treatment of myocardial infarction by phosphorus-31 NMR with surface coils (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-09
    Description: Phosphorus-31 nuclear magnetic resonance (NMR) measurements with small surface coils have been used to observe phosphorus metabolism of perfused hearts within localized regions. The method allows for direct, noninvasive, sequential assessment of the altered regional metabolism resulting from myocardial infarction and its response to drug treatment, which cannot be observed by conventional techniques.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nunnally, R L -- Bottomley, P A -- GM 17172/GM/NIGMS NIH HHS/ -- HL 17655-06/HL/NHLBI NIH HHS/ -- HL 22080/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1981 Jan 9;211(4478):177-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7444460" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chlorpromazine/therapeutic use ; Coronary Circulation/drug effects ; Disease Models, Animal ; Magnetic Resonance Spectroscopy/*methods ; Myocardial Infarction/*diagnosis/drug therapy/metabolism ; Phosphorus/*metabolism ; Phosphorus Isotopes ; Rabbits ; Verapamil/therapeutic use
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 119
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    Hyperkeratosis induced by sunlight degradation products of the major polybrominated biphenyl in Firemaster (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-21
    Description: Sunlight photodegradation of 2,2', 4,4', 5,5' -hexabromobiphenyl, the major component of Firemaster, gave a mixture that produces severe hyperkeratosis of the rabbit ear. This component in its pure state does not cause hyperkeratosis. One or more of the four major photolysis products must be responsible for this activity. A similar photodegradation pattern was observed for 2,2', 3,4,4', 5,5' -heptabromobiphenyl, the second largest component of Firemaster.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Patterson, D G -- Hill, R H -- Needham, L L -- Orti, D L -- Kimbrough, R D -- Liddle, J A -- New York, N.Y. -- Science. 1981 Aug 21;213(4510):901-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6266016" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biphenyl Compounds/radiation effects ; Chemical Industry ; Disease Models, Animal ; Environmental Exposure ; Keratosis/*chemically induced ; Michigan ; Photochemistry ; *Polybrominated Biphenyls/radiation effects ; Rabbits ; Sunlight
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    Destruction of noradrenergic neurons in rabbit brainstem elevates plasma vasopressin, causing hypertension (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-13
    Description: When A1 noradrenergic neurons in the caudal ventrolateral medulla of rabbits are destroyed electrolytically or by local injection of the neurotoxin kainic acid, the concentration of vasopressin in plasma increases, causing hypertension. The A1 neurons may tonically inhibit the activity of vasopressin-secreting neuroendocrine cells through a direct hypothalamic projection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blessing, W W -- Sved, A F -- Reis, D J -- HL 1894/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 13;217(4560):661-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6124043" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic Fibers/*physiology ; Animals ; Arginine Vasopressin/*blood ; Blood Pressure ; Brain Stem/*physiology ; Glutamates/pharmacology ; Glutamic Acid ; Hypertension/*etiology ; Hypothalamus/physiology ; Kainic Acid/pharmacology ; Male ; Neurosecretion ; Norepinephrine/physiology ; Rabbits
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Lyme disease-a tick-borne spirochetosis? (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-18
    Description: A treponema-like spirochete was detected in and isolated from adult Ixodes dammini, the incriminated tick vector of Lyme disease. Causally related to the spirochetes may be long-lasting cutaneous lesions that appeared on New Zealand White rabbits 10 to 12 weeks after infected ticks fed on them. Samples of serum from patients with Lyme disease were shown by indirect immunofluorescence to contain antibodies to this agent. It is suggested that the newly discovered spirochete is involved in the etiology of Lyme disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burgdorfer, W -- Barbour, A G -- Hayes, S F -- Benach, J L -- Grunwaldt, E -- Davis, J P -- New York, N.Y. -- Science. 1982 Jun 18;216(4552):1317-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7043737" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachnid Vectors/*microbiology ; Arthritis, Infectious/*microbiology ; Digestive System/microbiology ; Fluorescent Antibody Technique ; Humans ; Microscopy, Electron ; Microvilli/microbiology/ultrastructure ; Rabbits ; Seasons ; Spirochaetales/ultrastructure ; Spirochaetales Infections/*microbiology ; Ticks/*microbiology
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    Naloxone reverses neonatal depression caused by fetal asphyxia (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-06-11
    Description: Pregnant near-term rabbits were given an intravenous dose of saline or the opiate antagonist naloxone and then asphyxiated. The fetuses were delivered by cesarean section and evaluated for respiration, color, muscle tone, response to stimulation, and general activity at 1, 3, 5, 10, 15, and 30 minutes of age. The naloxone-treated pups had significantly better scores during the first 15 minutes after birth than the saline-treated pups. Naloxone did not adversely affect the scores of nonasphyxiated pups. These data suggest that endogenous opiates worsen the neonatal depression caused by intrauterine asphyxia and that this effect can be reversed by naloxone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chernick, V -- Craig, R J -- New York, N.Y. -- Science. 1982 Jun 11;216(4551):1252-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7200636" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn/*physiology ; Asphyxia Neonatorum/complications/*physiopathology ; Depression/prevention & control ; Disease Models, Animal ; Humans ; Infant, Newborn ; Naloxone/*pharmacology ; Rabbits
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    Phagocyte impotence caused by an invasive bacterial adenylate cyclase (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-03
    Description: For unknown reasons, humans infected with the bacterium Bordetella pertussis are exceptionally vulnerable to secondary infections. Bordetella species elaborate a soluble, heat-stable, and highly active adenylate cyclase. This enzyme is internalized by phagocytic cells and catalyzes the unregulated formation of adenosine 3',5'-monophosphate (cyclic AMP), thereby disrupting normal cellular function. This unusual phenomenon may explain Bordetella-induced aphylaxis and may prove to be useful for investigating a variety of cyclic AMP-governed processes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Confer, D L -- Eaton, J W -- 5T32H- L07062/PHS HHS/ -- New York, N.Y. -- Science. 1982 Sep 3;217(4563):948-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6287574" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/*metabolism ; Animals ; Bordetella pertussis/*enzymology ; Cells, Cultured ; Cyclic AMP/biosynthesis ; Humans ; Macrophages/physiology ; Neutrophils/physiology ; Phagocytes/*physiology ; Rabbits ; Superoxides/metabolism ; Temperature
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    Rotating shift work schedules that disrupt sleep are improved by applying circadian principles (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-30
    Description: Workers on rotating shifts dislike those aspects of their work schedules that violate circadian sleep-wake cycle physiology. Work schedule satisfaction, subjective health estimates, personnel turnover, and worker productivity improve when schedules are introduced that are designed to incorporate circadian principles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Czeisler, C A -- Moore-Ede, M C -- Coleman, R H -- New York, N.Y. -- Science. 1982 Jul 30;217(4558):460-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089576" target="_blank"〉PubMed〈/a〉
    Keywords: *Activity Cycles ; Adult ; Aged ; *Circadian Rhythm ; Health ; Humans ; Job Satisfaction ; Male ; Middle Aged ; *Sleep ; *Work
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    Rabbit hepatic progesterone 21-hydroxylase exhibits a bimodal distribution of activity (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-08-20
    Description: Progesterone 21-hydroxylase activity varies extensively among liver microsomes prepared from individual New Zealand White (NZW) rabbits. The 21-hydroxylase activities are distributed between two groupings that differ by more than tenfold in mean activity. Both male and female animals are represented in the two groupings. However, females exhibited the higher activity more frequently than males. The 21-hydroxylation of progesterone is catalyzed by one of the liver microsomal cytochrome P-450 isozymes, form 1, and these differences in activity are suggestive of differences in the occurrence of this isozyme among NZW rabbits.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dieter, H H -- Muller-Eberhard, U -- Johnson, E F -- HD04445/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 20;217(4561):741-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6808664" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cytochrome P-450 Enzyme System/metabolism ; Desoxycorticosterone/metabolism ; Female ; Isoenzymes/metabolism ; Liver/*enzymology ; Male ; Microsomes, Liver/metabolism ; NADPH-Ferrihemoprotein Reductase/metabolism ; Progesterone/*metabolism ; Rabbits ; Sex Factors ; Steroid 21-Hydroxylase/*metabolism ; Steroid Hydroxylases/*metabolism
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    Decreased insulin receptors but normal glucose metabolism in Duchenne muscular dystrophy (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-04-16
    Description: Compared to matched controls, 17 patients with Duchenne muscular dystrophy showed decreased insulin binding to monocytes due to decreased receptor concentration. These patients showed no signs of altered glucose metabolism and retrospective analysis of the clinical records of a further 56 such patients revealed no modification in carbohydrate metabolism. These data suggest that reduced insulin receptor number does not produce overt modifications of glucose metabolism in Duchenne muscular dystrophy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉DePirro, R -- Lauro, R -- Testa, I -- Ferretti, I -- De Martinis, C -- Dellatonio, R -- New York, N.Y. -- Science. 1982 Apr 16;216(4543):311-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063889" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Cell Membrane/metabolism ; Child ; Glucose/*metabolism ; Humans ; Monocytes/metabolism ; Muscular Dystrophies/*metabolism ; Receptor, Insulin/*metabolism
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    Lipofuscin: resolution of discrepant fluorescence data (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-05-14
    Description: Lipofuscin granules (age pigments) emit yellow light under ultraviolet excitation in the fluorescence microscope. The reported blue emission maximum of extracts of lipofuscin-laden cells may result from instrumental bias. The major fluorescent components that accumulate with age in these lysosomal residual bodies of human retinal pigment epithelium are yellow-emitting fluorophores. Different age-related fluorophores, which do emit blue light, are derived from other intracellular sources. A reevaluation of the connection between blue-emitting lipid peroxidation products and the age-related lipofuscin granules of classical pathology is necessary.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eldred, G E -- Miller, G V -- Stark, W S -- Feeney-Burns, L -- EY 03274/EY/NEI NIH HHS/ -- EY 03408/EY/NEI NIH HHS/ -- EY 05456/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1982 May 14;216(4547):757-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079738" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Age Factors ; Cytoplasmic Granules ; Humans ; *Lipofuscin ; Lysosomes/analysis ; Pigment Epithelium of Eye/analysis/ultrastructure ; *Pigments, Biological ; Spectrometry, Fluorescence ; Spectrum Analysis
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    Cholinergic agonists induce vectorial release of serotonin from duodenal enterochromaffin cells (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-23
    Description: Serotonin-containing enterochromaffin cells in the rabbit duodenal mucosa span the tissue contacting both the luminal and serosal sides. When the serosal surface is stimulated with carbachol in vitro, serotonin is secreted on the serosal side but not the mucosal side. Carbachol added to the luminal side is ineffective. Atropine but not hexamethonium blocks the effect of carbachol. Acetylcholine on the serosal surface also stimulates serotonin release on the serosal side. These findings indicate that enterochromaffin cells possess on their serosal surfaces muscarinic receptors that mediate vectorial release of serotonin when activated by cholinergic agonists.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Forsberg, E J -- Miller, R J -- DA 02121/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 23;217(4557):355-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089569" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/pharmacology ; Animals ; Atropine/pharmacology ; Carbachol/pharmacology ; Chromaffin System/*secretion ; Duodenum/physiology ; Enterochromaffin Cells/*secretion ; Hexamethonium Compounds/pharmacology ; In Vitro Techniques ; Intestinal Mucosa/drug effects ; Parasympathomimetics/*pharmacology ; Rabbits ; Receptors, Muscarinic/metabolism ; Serotonin/*secretion ; Serous Membrane/drug effects
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    Sugar infusion can enhance feeding (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-10-29
    Description: An investigation was made of the role of glucose in the regulation of hunger and satiety in the rabbit. Glucose, when infused intraduodenally at a low rate (1 milliliter per minute), produced a decrease in food intake. However, when glucose was infused into the duodenum at a high rate (3 milliliters per minute), the rabbits nearly doubled their food intake during the first half-hour after infusion. It is hypothesized that the rapid arrival and glucose in the duodenum may produce hunger.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Geiselman, P J -- Novin, D -- NS7687/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 29;218(4571):490-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123251" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Glucose/physiology ; Duodenum/*physiology ; Female ; Glucose/administration & dosage/*pharmacology ; Rabbits ; Satiation/*drug effects ; Satiety Response/*drug effects
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    Interspecies variations in mammalian lens metabolites as detected by phosphorus-31 nuclear magnetic resonance (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-03-26
    Description: Multiple interspecies differences were detected between humans and seven other mammals in 15 of the 24 metabolites measured in the intact crystalline lens and lens perchloric acid extracts. Generally, the number of statistically significant metabolite differences among the various species, relative to the human, increase in the following order: cat or approximately dog greater than pig greater than rat greater than sheep greater than rabbit greater than cow.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kopp, S J -- Glonek, T -- Greiner, J V -- New York, N.Y. -- Science. 1982 Mar 26;215(4540):1622-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7071581" target="_blank"〉PubMed〈/a〉
    Keywords: Adenine Nucleotides/metabolism ; Animals ; Carbohydrate Metabolism ; Cats ; Choline/metabolism ; Dogs ; Humans ; Lens, Crystalline/*metabolism ; Magnetic Resonance Spectroscopy ; Phosphocreatine/metabolism ; Rabbits ; Rats ; Species Specificity
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    New angiogenesis inhibitor identified (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-06-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H -- New York, N.Y. -- Science. 1982 Jun 18;216(4552):1304.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6177046" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cornea/blood supply ; Neovascularization, Pathologic/*drug effects ; Protamines/*pharmacology ; Rabbits
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    Sleep-promoting factor isolated (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-06-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1982 Jun 25;216(4553):1400.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6124035" target="_blank"〉PubMed〈/a〉
    Keywords: *Acetylmuramyl-Alanyl-Isoglutamine/*analogs & derivatives ; Alanine/analysis ; Animals ; Cats ; Diaminopimelic Acid/analysis ; Glutamates/analysis ; Glutamic Acid ; Glycopeptides/*urine ; Humans ; Intestines/microbiology ; Muramic Acids/analysis ; Polysaccharides, Bacterial/analysis ; Rabbits ; Rats ; Sleep/*drug effects
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    A new treatment for burn victims (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-08-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1982 Aug 6;217(4559):522.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089578" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; *Bandages ; *Biological Dressings ; Burns/*therapy ; Cells, Cultured ; Child ; Child, Preschool ; Epidermis/cytology ; Humans ; Surgical Flaps ; Wound Healing
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    A new marker for diabetes (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-02-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1982 Feb 5;215(4533):651.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7058330" target="_blank"〉PubMed〈/a〉
    Keywords: Adipose Tissue/pathology ; Adult ; Diabetes Mellitus/*pathology ; Female ; Humans ; Male ; *Obesity ; Sex Factors
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    Selective, naloxone-reversible morphine depression of learned behavioral and hippocampal responses (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-04-23
    Description: Morphine administered intravenously causes immediate and complete abolition of a simple learned response (classically conditioned nictitating membrane extension in rabbit) and of the associated learning-induced increase in hippocampal neuron activity. Both effects are completely reversed by low doses of naloxone. Morphine has no effect at all on behavioral performance of the unconditioned reflex response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mauk, M D -- Warren, J T -- Thompson, R F -- New York, N.Y. -- Science. 1982 Apr 23;216(4544):434-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7071592" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*drug effects ; Conditioning (Psychology)/*drug effects ; Hippocampus/*physiology ; Memory/drug effects ; Morphine/antagonists & inhibitors/*pharmacology ; Naloxone/pharmacology ; Rabbits
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    Neonatal treatment with antiserum to prolactin lowers blood pressure in rats (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-09
    Description: Prolactin administration reportedly increases blood pressure in rats and rabbits. To study the effects of prolactin deficiency on blood pressure, rats were given saline, normal rabbit serum, or rabbit antiserum to rat prolactin on postnatal days 2 to 5. Both males and females given antiserum had significantly lower blood pressure at 14 weeks than rats given saline or normal rabbit serum. Blood pressure differences between females given antiserum and females given saline disappeared during and following pregnancy. The antiserum also lowered the concentration of prolactin in plasma 49 percent in males and decreased the prolactin response to ether stress in both sexes. These results suggest that endogenous prolactin is involved in blood pressure regulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mills, D E -- Buckman, M T -- Peake, G T -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):162-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089550" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; *Blood Pressure ; Female ; Immune Sera/pharmacology ; Male ; Pregnancy ; Pregnancy, Animal ; Prolactin/blood/immunology/*physiology ; Rabbits ; Rats ; Rats, Inbred Strains ; Sex Characteristics ; Sodium Chloride/pharmacology
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    Bilirubin-induced modulation of cerebral protein phosphorylation in neonate rabbits in vivo (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-08
    Description: Protein phosphorylation in cerebral cell-free preparations from neonate rabbits was inhibited by bilirubin and promoted by aminophylline when these substances had been administered intravenously. In animals given both compounds, the bilirubin-induced inhibition of phosphorylation was partly reversed by aminophylline. Adenosine 3',5'-monophosphate added in vitro during the assays also increased protein phosphorylation. These data introduce new concepts in the pathogenesis of kernicterus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morphis, L -- Constantopoulos, A -- Matsaniotis, N -- Papaphilis, A -- New York, N.Y. -- Science. 1982 Oct 8;218(4568):156-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123226" target="_blank"〉PubMed〈/a〉
    Keywords: Aminophylline/pharmacology ; Animals ; Animals, Newborn ; Bilirubin/metabolism/*pharmacology ; Brain/drug effects/*metabolism ; Kinetics ; Nerve Tissue Proteins/*metabolism ; Phosphorylation ; Protein Kinases/*metabolism ; Rabbits
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  • 138
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    Calcium and age in fibroblasts from control subjects and patients with cystic fibrosis (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-04-23
    Description: Intracellular calcium increases significantly as human fibroblasts age in culture. The calcium increase occurs 5 to 6 weeks (passages) earlier and is significantly greater in fibroblasts from subjects with cystic fibrosis in comparison with cells from control subjects. Intracellular calcium, which is thought to be a pathogenetic factor in cystic fibrosis, may also be a meaningful marker in cell aging.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shapiro, B L -- Lam, L F -- AG-02114/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1982 Apr 23;216(4544):417-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7071590" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Calcium/*metabolism ; *Cell Survival ; Cells, Cultured ; Child ; Cystic Fibrosis/*metabolism/pathology ; Female ; Fibroblasts ; Humans ; Infant ; Male
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  • 139
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    Luteal phase defects induced by an agonist of luteinizing hormone-releasing factor: a model for fertility control (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-08
    Description: Subcutaneous injection of 50 micrograms of a luteinizing hormone-releasing factor agonist (LRF agonist) for three successive days at the time of menstruation in normal cycling women induces a shortened luteal phase with suboptimal concentrations of circulating estradiol and progesterone. This luteal phase defect follows a reduced concentration of follicle-stimulating hormone during the follicular phase and a resulting inadequate follicular maturation. Since a short luteal phase is associated with an endometrium not conductive to implantation, administration of the LRF agonist at the onset of menstrual cycle may prove to be a practical and novel approach to fertility control.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sheehan, K L -- Casper, R F -- Yen, S S -- HD-12303/HD/NICHD NIH HHS/ -- N01HD-92842/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 8;215(4529):170-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6797068" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Contraception ; Estradiol/blood ; Female ; Follicle Stimulating Hormone/blood/metabolism ; Gonadotropin-Releasing Hormone/*analogs & derivatives/pharmacology ; Humans ; Luteinizing Hormone/blood ; Menstruation/drug effects ; Progesterone/blood ; *Triptorelin Pamoate/*analogs & derivatives
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 140
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    Diazepam impairs lateral position control in highway driving (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-02
    Description: Nine expert drivers operated an instrumented vehicle in tests over a highway at night after being treated with diazepam (5 and 10 milligrams), a placebo, and nothing. They reacted to 10 milligrams of diazepam with increased lateral position variability. Potentially dangerous impairment was inferred from the reactions of some subjects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Hanlon, J F -- Haak, T W -- Blaauw, G J -- Riemersma, J B -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):79-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089544" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Automobile Driving ; Diazepam/*pharmacology ; Dose-Response Relationship, Drug ; Double-Blind Method ; Functional Laterality ; Humans ; Male ; Motor Activity/*drug effects ; Placebos
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  • 141
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    Familial renal cell carcinoma with a 3;11 chromosome translocation limited to tumor cells (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-03
    Description: Cytogenic studies were performed on the direct chromosome preparations of the renal cell carcinoma cells and the cultured peripheral blood lymphocytes of a patient with familial renal cell carcinoma. The results revealed a specific, acquired translocations (3p;11p) present in the majority of metaphases of the tumor, indicating that the development of renal cell carcinoma is associated with a deletion in the proximal end of 3p. Renal cell carcinoma is thus the third example--the first two being retinoblastoma and Wilms' tumor--of a chromosomal deletion occurring germinally or somatically in association with a specific tumor. This finding adds further support to the existence of specific human cancer genes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pathak, S -- Strong, L C -- Ferrell, R E -- Trindade, A -- CA 27925/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Sep 3;217(4563):939-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7112106" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/*genetics ; Adult ; Chromosome Banding ; Chromosomes, Human, 1-3/*ultrastructure ; Chromosomes, Human, 6-12 and X/*ultrastructure ; Female ; Humans ; Karyotyping ; Kidney Neoplasms/*genetics ; Lymphocytes/ultrastructure ; Male ; Pedigree ; *Translocation, Genetic
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  • 142
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    Use of "Super-plus" tampons discouraged (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1982 Jun 18;216(4552):1300.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6281894" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Centers for Disease Control and Prevention (U.S.) ; Female ; Humans ; *Menstruation ; Shock, Septic/*etiology ; Tampons, Surgical/*adverse effects ; United States
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  • 143
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    Bronchoconstrictor effects of leukotriene C in humans (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-04-09
    Description: Maximum expiratory flow rate at 30 percent of vital capacity above residual volume served as an index of airway obstruction in comparing the effects of leukotriene C and histamine administered by aerosol to five normal persons. Leukotriene C was 600 to 9500 times more potent than histamine on a molar basis in producing an equivalent decrement in the residual volume. The leukotriene C response was slow in onset and prolonged, reminiscent of the effects of aerosol allergen challenge in asthmatic allergic subjects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weiss, J W -- Drazen, J M -- Coles, N -- McFadden, E R Jr -- Weller, P F -- Corey, E J -- Lewis, R A -- Austen, K F -- AI-00399/AI/NIAID NIH HHS/ -- AI-07722/AI/NIAID NIH HHS/ -- AI-10356/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1982 Apr 9;216(4542):196-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063880" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Airway Resistance/*drug effects ; Bronchi/*drug effects ; Dose-Response Relationship, Drug ; Female ; Histamine/pharmacology ; Humans ; Male ; Middle Aged ; Prostaglandins F/pharmacology ; SRS-A/*pharmacology ; Time Factors
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  • 144
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    Running and breathing in mammals (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-01-21
    Description: Mechanical constraints appear to require that locomotion and breathing be synchronized in running mammals. Phase locking of limb and respiratory frequency has now been recorded during treadmill running in jackrabbits and during locomotion on solid ground in dogs, horses, and humans. Quadrupedal species normally synchronize the locomotor and respiratory cycles at a constant ratio of 1:1 (strides per breath) in both the trot and gallop. Human runners differ from quadrupeds in that while running they employ several phase-locked patterns (4:1, 3:1, 2:1, 1:1, 5:2, and 3:2), although a 2:1 coupling ratio appears to be favored. Even though the evolution of bipedal gait has reduced the mechanical constraints on respiration in man, thereby permitting greater flexibility in breathing pattern, it has seemingly not eliminated the need for the synchronization of respiration and body motion during sustained running. Flying birds have independently achieved phase-locked locomotor and respiratory cycles. This hints that strict locomotor-respiratory coupling may be a vital factor in the sustained aerobic exercise of endothermic vertebrates, especially those in which the stresses of locomotion tend to deform the thoracic complex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bramble, D M -- Carrier, D R -- New York, N.Y. -- Science. 1983 Jan 21;219(4582):251-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6849136" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Gait ; Horses ; Humans ; *Locomotion ; Mammals ; *Physical Exertion ; Rabbits ; *Respiration
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  • 145
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    Uphill sodium transport driven by an inward calcium gradient in heart muscle (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-01-14
    Description: Heart cells were loaded with sodium by treatment with toxic doses of acetyl strophanthidin. After this treatment, an increase in extracellular calcium resulted in a transient net outward sodium flux against its electrochemical gradient and in net cellular uptake of calcium. It is concluded that the free energy for the net outward sodium movement was derived from the increased calcium gradient and that these ion movements took place through the sodium-calcium exchange. While in the normal physiological state the sodium-calcium exchange produces calcium extrusion from the cell, these experiments demonstrate its reversibility.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521047/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521047/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bridge, J H -- Bassingthwaighte, J B -- P41 RR001243/RR/NCRR NIH HHS/ -- P41 RR001243-190021/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1983 Jan 14;219(4581):178-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6849128" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport, Active ; Calcium/*metabolism ; Cytoplasm/metabolism ; Membrane Potentials ; Myocardium/*metabolism ; Potassium/metabolism ; Rabbits ; Sarcolemma/metabolism ; Sodium/*metabolism
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  • 146
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    Shark cartilage contains inhibitors of tumor angiogenesis (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-09-16
    Description: Shark cartilage contains a substance that strongly inhibits the growth of new blood vessels toward solid tumors, thereby restricting tumor growth. The abundance of this factor in shark cartilage, in contrast to cartilage from mammalian sources, may make sharks an ideal source of the inhibitor and may help to explain the rarity of neoplasms in these animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, A -- Langer, R -- EY04002/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 16;221(4616):1185-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6193581" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cartilage/*physiology ; Cell Line ; Cornea ; Neoplasms/*blood supply ; *Neovascularization, Pathologic ; Rabbits ; Sharks
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  • 147
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    Psychological stress induces sodium and fluid retention in men at high risk for hypertension (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-22
    Description: Exposure to competitive mental tasks significantly reduced the urinary sodium and fluid excreted by young men with one or two hypertensive parents or with borderline hypertension. In this high-risk group, the degree of retention was directly related to the magnitude of heart rate increase during stress, suggesting common mediation by way of the sympathetic nervous system. Thus, psychological stress appears to induce changes in renal excretory functions that may play a critical role in long-term blood pressure regulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Light, K C -- Koepke, J P -- Obrist, P A -- Willis, P W 4th -- HL-01096/HL/NHLBI NIH HHS/ -- HL-18976/HL/NHLBI NIH HHS/ -- HL-23718/HL/NHLBI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Apr 22;220(4595):429-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836285" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Blood Pressure ; Heart Rate ; Humans ; Hypertension/etiology/*physiopathology ; Kidney/physiopathology ; Male ; Risk ; Sodium/*metabolism ; Stress, Psychological/metabolism/*physiopathology ; *Water-Electrolyte Balance
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  • 148
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    Erectile mechanisms in man (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-06-03
    Description: Increases in penile circumference during sleep-related erections in human subjects closely reflected increases in penile blood flow, and bursts of activity in the bulbocavernosus and ischiocavernosus muscles were temporally related to these increases. The penile arterial system and the perineal muscles appear to have important coordinated roles in human penile erection. Monitoring sleep-related erections and penile blood flow holds promise for the study of erectile mechanisms and dysfunction and for screening of drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Karacan, I -- Aslan, C -- Hirshkowitz, M -- AG02414-03/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 3;220(4601):1080-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6844930" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Electroencephalography ; Electromyography ; Electrooculography ; Heart Rate ; Humans ; Male ; Penis/blood supply/*physiology ; Sleep/physiology
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  • 149
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    Turnover, membrane insertion, and degradation of sodium channels in rabbit urinary bladder (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-09-23
    Description: Noise analysis of rabbit bladder revealed two components: Lorentzian noise, arising from interaction of amiloride with the Na+ channel, and flicker noise (l/f, where f is frequency), as in other biological membranes. Hydrostatic pressure, which causes exchange between intracellular vesicular membrane and apical membrane, increases the number but not the single-channel current of the amiloride-sensitive channels. Flicker noise arises from degraded channels that have lost amiloride sensitivity and Na+ to K+ selectivity. The degraded channels were selectively removed by washing the mucosal surface. These results imply channel turnover by intracellular synthesis, transfer from vesicular to apical membrane, degradation, and elimination.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Loo, D D -- Lewis, S A -- Ifshin, M S -- Diamond, J M -- AM17327/AM/NIADDK NIH HHS/ -- AM20851/AM/NIADDK NIH HHS/ -- GM14772/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 23;221(4617):1288-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6612343" target="_blank"〉PubMed〈/a〉
    Keywords: Amiloride/pharmacology ; Animals ; Cell Membrane/metabolism ; Cytoplasmic Granules/metabolism ; Epithelium/physiology ; Rabbits ; Sodium/*metabolism ; Urinary Bladder/*metabolism
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  • 150
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    Antipyretic potency of centrally administered alpha-melanocyte stimulating hormone (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-07-08
    Description: Centrally administered alpha-melanocyte stimulating hormone is much more potent in reducing fever than the widely used antipyretic acetaminophen. This finding supports the hypothesis that the endogenous neuropeptide has a role in the limitation of fever and suggests that it may be clinically useful as an antipyretic.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murphy, M T -- Richards, D B -- Lipton, J M -- NS 10046/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):192-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6602381" target="_blank"〉PubMed〈/a〉
    Keywords: Acetaminophen/pharmacology ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/*pharmacology ; Body Temperature/drug effects ; Dose-Response Relationship, Drug ; Fever/drug therapy ; Humans ; Melanocyte-Stimulating Hormones/*pharmacology ; Rabbits
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  • 151
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    Memory performance of chemical workers exposed to polybrominated biphenyls (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-06-19
    Description: Twenty-five chemical workers who manufactured polybrominated biphenyls (PBB's) were given objective tests of learning and memory. Although this group had high concentrations of PBB's in adipose tissue, mean scores on all memory tests were normal. The PBB concentration was not correlated with memory performance; the most contaminated workers showed no evidence of memory dysfunction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, G G -- Preisman, R C -- Anderson, M D -- Nixon, R K -- Isbister, J L -- Price, H A -- New York, N.Y. -- Science. 1981 Jun 19;212(4501):1413-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6262920" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Biphenyl Compounds/*adverse effects ; Humans ; Learning/*drug effects ; Memory/*drug effects ; Polybrominated Biphenyls/*adverse effects ; Psychological Tests
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  • 152
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    Difference in brain densities between chronic alcoholic and normal control patients (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-01-30
    Description: The densities of the brains of 11 chronic alcoholics were compared with those of 11 age-matched normal control subjects. Densities were determined from the density numbers generated by computerized tomography at three levels of the brain-the highest level of the lateral ventricles and the next two higher levels-with adjustments made to control for possible artifacts in the data. The advantage of the dominant hemisphere over the nondominant hemisphere was lessened in alcoholics.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Golden, C J -- Graber, B -- Blose, I -- Berg, R -- Coffman, J -- Bloch, S -- New York, N.Y. -- Science. 1981 Jan 30;211(4481):508-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7455693" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Alcoholism/*pathology ; Brain/*pathology ; Functional Laterality ; Humans ; Tomography, X-Ray Computed
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  • 153
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    Essential hypertension: central and peripheral norepinephrine (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-02-27
    Description: The concentration of norepinephrine in cerebrospinal fluid from patients with essential hypertension is higher than that from healthy normal volunteers, but the concentrations of norepinephrine in plasma from these groups are similar. This finding indicates that central nervous system noradrenergic hyperactivity occurs in essential hypertension but apparently is not reflected in abnormal function of the peripheral sympathetic nervous system in these patients.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lake, C R -- Gullner, H G -- Polinsky, R J -- Ebert, M H -- Ziegler, M G -- Bartter, F C -- New York, N.Y. -- Science. 1981 Feb 27;211(4485):955-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466370" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Blood Pressure ; Female ; Humans ; Hypertension/blood/*cerebrospinal fluid ; Middle Aged ; Norepinephrine/blood/*cerebrospinal fluid ; Posture
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  • 154
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    Nitrogen-13-labeled nitrite and nitrate: distribution and metabolism after intratracheal administration (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: Radioactive nitrogen-13 from nitrite (NO2-) or nitrate (NO3-) administered intratracheally or intravenously without added carrier to mice or rabbits was distributed evenly throughout most organs and tissues regardless of the entry route or the anion administered. Nitrogen-13 from both anions was distributed uniformly between plasma and blood cells. We found rapid in vivo oxidation of NO2- to NO3- at concentrations of 2 to 3 nanomoles per liter in blood. Over 50 percent oxidation within 10 minutes accounted for the similar nitrogen-13 distributions from both parent ions. The oxidation rates were animal species-dependent. No reduction of 13NO3- to 13NO2- was observed. A mechanistic hypothesis invoking oxidation of 13NO2- by a catalase-hydrogen peroxide complex accounts for the results. These results imply a concentration dependence for the in vivo fate of NO2- or nitrogen dioxide.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Parks, N J -- Krohn, K J -- Mathis, C A -- Chasko, J H -- Geiger, K R -- Gregor, M E -- Peek, N F -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):58-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209517" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromatography, High Pressure Liquid ; Injections, Intravenous ; Mice ; Mice, Inbred BALB C ; Nitrates/administration & dosage/*metabolism ; Nitrites/administration & dosage/*metabolism ; Nitrogen Isotopes ; Oxidation-Reduction ; Rabbits ; Species Specificity ; Tissue Distribution ; Trachea
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  • 155
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    Plasmid DNA in Treponema pallidum (Nichols): potential for antibiotic resistance by syphilis bacteria (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-31
    Description: A plasmid DNA structure (approximate molecular weight = 7.5 X 10(6)) was identified in the human pathogen Treponema pallidum (Nichols). The inability to isolate this plasmid from rabbit host tissue and the total lack of DNA homology of the plasmid with rabbit DNA has confirmed its Treponema pallidum origin. The observation documents a newly recognized and potentially significant genetic capability for Treponema pallidum.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norgard, M V -- Miller, J N -- NIAID-12601/AI/NIAID NIH HHS/ -- NIAID-16692/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):553-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6264606" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; DNA Restriction Enzymes ; DNA, Bacterial/*genetics ; DNA, Recombinant/metabolism ; Drug Resistance, Microbial ; Microscopy, Electron ; Molecular Weight ; Nucleic Acid Hybridization ; *Plasmids ; Protein Biosynthesis ; Rabbits ; Treponema pallidum/*genetics
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  • 156
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    Slow-wave sleep: a recovery period after exercise (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-12-11
    Description: Sleep recordings were carried out on athletes on four successive nights after completing a 92-kilometer road race. Significant increases in total sleep time and slow-wave sleep were found after this metabolic stress. The results show a definite exercise effect on sleep and support sleep-restoration hypotheses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shapiro, C M -- Bortz, R -- Mitchell, D -- Bartel, P -- Jooste, P -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1253-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302594" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Humans ; *Physical Exertion ; Running ; Sleep Stages/*physiology ; Sleep, REM/physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 157
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    Species restriction of a monoclonal antibody reacting with residues 130 to 137 in encephalitogenic myelin basic protein (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-02
    Description: A monoclonal antibody (immunoglobulin G1) has been produced that reacts against myelin basic protein present in or extracted from the brains of many mammals-with certain important exceptions. Because of known species differences in amino acid sequences of basic protein and of certain peptide fragments, the binding site for this particular antibody appeared likely to include residues 130 to 137. Confirmation of this hypothesis was obtained by amino acid composition of the major immunoreactive peptides produced by thermolysin digestion of human basic protein and isolated by high-performance liquid chromatography.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sires, L R -- Hruby, S -- Alvord, E C Jr -- Hellstrom, I -- Hellstrom, K E -- Kies, M W -- Martemspm, R -- Deibler, G E -- Beckman, E D -- Casnellie, J E -- CA-19148/CA/NCI NIH HHS/ -- CA-25558/CA/NCI NIH HHS/ -- CA-26584/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Oct 2;214(4516):87-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6169147" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Antibodies, Monoclonal ; Cattle ; Chickens ; Epitopes ; Guinea Pigs ; Humans ; Macaca ; Myelin Basic Protein/*immunology ; Peptide Fragments/immunology ; Rabbits ; Rats ; Species Specificity
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  • 158
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    Molecular and cellular mechanisms of leukocyte chemotaxis (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-21
    Description: The application of modern scientific methods to the study of leukocyte function has begun to reveal the molecular and cytostructural bases of the chemotactic responses of these cells. Leukocyte chemotaxis is initiated by the binding of chemoattractants to distinct plasma membrane receptors; this finding alters transmembrane potential and activates ionic fluxes. The subsequent sequence of metabolic processes leads to a rearrangement of cytoskeletal elements that is manifested by orientation and migration of the cells toward the source of the chemotactic gradient.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Snyderman, R -- Goetzl, E J -- HL 19777/HL/NHLBI NIH HHS/ -- R01 DE 03738/DE/NIDCR NIH HHS/ -- New York, N.Y. -- Science. 1981 Aug 21;213(4510):830-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6266014" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Membrane/physiology ; Chemotactic Factors/*physiology ; *Chemotaxis, Leukocyte ; Cytoskeleton/*physiology ; Electric Conductivity ; Guinea Pigs ; Humans ; Lymphokines/physiology ; Microscopy, Electron, Scanning ; Microtubules/*physiology ; Neutrophils/physiology ; Nucleotides, Cyclic/physiology ; Rabbits ; Receptors, Cell Surface/*physiology ; Receptors, Formyl Peptide
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  • 159
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    Radioactivity measurements of former military personnel exposed to weapon debris (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-14
    Description: Sixteen former military personnel who were present at the "Smoky" atmospheric nuclear weapon test have been investigated for internal deposits of radioactivity. Whole-body and thorax gamma-ray measurements, thorax and skeletal actinide measurements, and urinalyses for plutonium-239 and strontium-90 indicated no evidence of radioactivity in excess of that found in the general population.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Toohey, R E -- Rundo, J -- Essling, M A -- Sha, J Y -- Oldham, R D -- Sedlet, J -- Robinson, J J -- New York, N.Y. -- Science. 1981 Aug 14;213(4509):767-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256278" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Humans ; Middle Aged ; *Military Medicine ; Plutonium/urine ; *Radiation Monitoring ; Strontium Radioisotopes/urine ; United States
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  • 160
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    Angiogenesis induced by "normal" human breast tissue: a probable marker for precancer (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-15
    Description: Normal human breast lobules, freshly isolated by precision microdissection of tissue stained with methylene blue chloride, were assayed for their ability to induce neovascularization (angiogenesis) in rabbit irises. Histologically, normal lobules from cancerous breast induced angiogenesis twice as often as lobules from noncancerous breasts, suggesting that preneoplastic transformation is diffuse.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jensen, H M -- Chen, I -- DeVault, M R -- Lewis, A E -- N01-CB-84316/CB/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 15;218(4569):293-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6181563" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Animals ; Breast/*physiology ; Female ; Humans ; Iris/*blood supply ; Middle Aged ; *Neovascularization, Pathologic ; Precancerous Conditions/*physiopathology ; Rabbits ; Time Factors
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  • 161
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    Simulating amnesic symptoms in normal subjects (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-17
    Description: Patients with organic brain damage resulting in anterograde amnesia cannot recall a list of words, but when given the first three letters of each word, they complete these word stems with words from the list. We simulated this phenomenon in normal subjects who examined the list words for vowels while ignoring their semantic component. The subjects produced the list words when completing the word stems although they could not recall the words.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Graf, P -- Mandler, G -- Haden, P E -- New York, N.Y. -- Science. 1982 Dec 17;218(4578):1243-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7146909" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Amnesia/*physiopathology ; Humans ; Memory/*physiology ; Mental Recall/physiology ; Models, Biological
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  • 162
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    Stimulation of colonic secretion by lipoxygenase metabolites of arachidonic acid (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-24
    Description: Both 5-hydroperoxyeicosatetraenoic acid (5-HPETE) and 5-hydroxyeicosatetraenoic acid (5-HETE) increased the short-circuit current (Isc) in rabbit colonic mucosa mounted in vitro in Ussing chambers. Measurements of chlorine-36 fluxes indicated that the Isc response to 5-HPETE is due to stimulation of active chlorine secretion. 9-, 11-, and 12-HPETE's and leukotrienes C4 and B4 produced either very small increases in Isc or no increase. In contrast to results in rabbit colon, no HPETE, HETE, or leukotriene was effective in rabbit ileal mucosa. The effects of 5-HPETE in the rabbit colon were unaffected by mepacrine, but could be partially blocked by indomethacin. These results suggest that drugs which block both cyclooxygenase and lipoxygenase may be effective antidiarrheals in patients with colitis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Musch, M W -- Miller, R J -- Field, M -- Siegel, M I -- AM 21345/AM/NIADDK NIH HHS/ -- DA 02121/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1982 Sep 24;217(4566):1255-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6810465" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachidonic Acids/*pharmacology ; Bicarbonates/metabolism ; Chlorides/metabolism ; Colitis/physiopathology ; Colon/*physiopathology ; Diarrhea/*physiopathology ; *Hydroxyeicosatetraenoic Acids ; Ileum/physiopathology ; Indomethacin/pharmacology ; *Leukotrienes ; *Lipoxygenase Inhibitors ; Rabbits
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  • 163
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    Depo-Provera debate revs up at FDA (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1982 Jul 30;217(4558):424-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6211767" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Carcinogens ; Contraceptive Agents, Female ; Dogs ; Drug Evaluation ; Drug Evaluation, Preclinical ; Female ; Humans ; International Agencies ; Medroxyprogesterone/adverse effects/*analogs & derivatives/pharmacology ; Medroxyprogesterone Acetate ; Risk ; United States ; United States Food and Drug Administration
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  • 164
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    Excretion of beta-phenethylamine is elevated in humans after profound stress (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-02-26
    Description: The urinary excretion rate of the endogenous, amphetamine-like substance beta-phenethylamine was markedly elevated in human subjects in association with an initial parachuting experience. The increases were delayed in most subjects and were not correlated with changes in urinary pH or creatinine excretion. The data suggest a stress-related role for beta-phenethylamine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Paulos, M A -- Tessel, R E -- DA-01614/DA/NIDA NIH HHS/ -- GM-27430/GM/NIGMS NIH HHS/ -- RR-05606/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1982 Feb 26;215(4536):1127-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063846" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; *Aerospace Medicine ; Creatinine/urine ; Female ; Humans ; Male ; Phenethylamines/*urine ; Stress, Physiological/*urine ; Time Factors
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  • 165
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    Crypts are the site of intestinal fluid and electrolyte secretion (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-17
    Description: The site of adenosine 3',5'-monophosphate-mediated fluid and electrolyte secretion across mammalian large intestine was found to be the crypts of Lieberkuhn by means of two techniques. First, the formation of fluid droplets was visualized on the oil-covered mucosal surface directly over crypt duct openings when secretion was stimulated. Second, microelectrode impalement of individual surface and crypt cells revealed that only crypts cells produced a pattern of secretagogue induced alterations in membrane potential and resistance that was characteristic of secretory epithelia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Welsh, M J -- Smith, P L -- Fromm, M -- Frizzell, R A -- AM-27524/AM/NIADDK NIH HHS/ -- AM-31091/AM/NIADDK NIH HHS/ -- HL-07159/HL/NHLBI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Dec 17;218(4578):1219-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6293054" target="_blank"〉PubMed〈/a〉
    Keywords: Amiloride/pharmacology ; Animals ; Chlorides/secretion ; Cyclic AMP/physiology ; In Vitro Techniques ; Intestine, Large/anatomy & histology/*physiology ; Prostaglandins E/pharmacology ; Rabbits ; Secretory Rate/drug effects ; Sodium/physiology ; *Water-Electrolyte Balance
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  • 166
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    Cancer chemotherapy (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cairns, J -- Boyle, D -- Frei, E 3rd -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):252, 254, 256.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836271" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Antineoplastic Agents/*therapeutic use ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Leukemia/drug therapy/mortality ; Male ; Neoplasms/*drug therapy/mortality ; United States
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  • 167
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    Endogenous pyrogen activity in human plasma after exercise (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-05-06
    Description: Plasma obtained from human subjects after exercise and injected intraperitoneally into rats elevated rat rectal temperature and depressed plasma iron and zinc concentrations. The pyrogenic component was heat-denaturable and had an apparent molecular weight of 14,000 daltons. Human mononuclear leukocytes obtained after exercise and incubated in vitro released a factor into the medium that also elevated body temperature in rats and reduced trace metal concentrations. These results suggest that endogenous pyrogen, a protein mediator of fever and trace metal metabolism during infection, is released during exercise.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cannon, J G -- Kluger, M J -- AI 13878/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1983 May 6;220(4597):617-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836306" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Body Temperature/drug effects ; Female ; Humans ; *Interleukin-1 ; Iron/blood ; Leukocytes/physiology ; Male ; Molecular Weight ; *Physical Exertion ; Proteins/physiology ; Pyrogens/blood/*metabolism ; Rats ; Rats, Inbred Strains ; Zinc/blood
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  • 168
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    Shadows of thought: shifting lateralization of human brain electrical patterns during brief visuomotor task (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-01
    Description: Dynamic spatial patterns of correlation of electrical potentials recorded from the human brain were shown in diagrams generated by mathematical pattern recognition. The patterns for "move" and "no-move" variants of a brief visuospatial task were compared. In the interval spanning the P300 peak of the evoked potential, higher correlations of the right parietal electrode with occipital and central electrodes distinguished the no-move task from the move task. In the next interval, spanning the readiness potential in the move task, higher correlations of the left central electrode with occipital and frontal electrodes characterized the move task. These results conform to neuropsychological expectations of localized processing and their temporal sequence. The rapid change in the side and site of localized processes may account for conflicting reports of lateralization in studies which lacked adequate spatial and temporal resolution.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gevins, A S -- Schaffer, R E -- Doyle, J C -- Cutillo, B A -- Tannehill, R S -- Bressler, S L -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):97-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828886" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Brain/*physiology ; Electroencephalography ; Evoked Potentials ; Female ; Functional Laterality/*physiology ; Humans ; Male ; Psychomotor Performance/*physiology
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  • 169
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    Accumulation of D-aspartic acid with age in the human brain (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-06-24
    Description: An age-related accumulation of D-aspartic acid was detected in the white matter of ten normal brains from individuals aged 30 to 80 years. Gray matter showed no systematic increase in D-aspartic acid. The rate constant for D-aspartate formation in the brain is equal to the predicted value calculated for 37 degrees C. Accumulation of the uncommon D-aspartate isomer in myelinated white matter implies that there is little or no turnover of this tissue, and this may have a bearing on dysfunction of the aging brain or on other diseases of myelin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Man, E H -- Sandhouse, M E -- Burg, J -- Fisher, G H -- New York, N.Y. -- Science. 1983 Jun 24;220(4604):1407-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857259" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; *Aging ; Aspartic Acid/*analysis/physiology ; *Brain Chemistry ; Eye Proteins/analysis ; Humans ; Lens Nucleus, Crystalline/analysis ; Middle Aged
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  • 170
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    Entamoeba histolytica causes intestinal secretion: role of serotonin (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-08-19
    Description: Lysates of the protozoan parasite Entamoeba histolytica altered active electrolyte transport when present on the serosal surface of rabbit ileum and rat colon. The lysate-induced effects on electrolyte transport were similar to those caused by serotonin, and were blocked by bufotenine, an analog known to inhibit the action of serotonin. The transport effects were partially inhibited by antibody to serotonin. The amebic lysates were shown to contain serotonin by radioimmunoassay, high-performance liquid chromatography, and thin-layer chromatography. These results suggest that the serotonin present in Entamoeba histolytica may be important in the diarrhea seen in amebiasis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McGowan, K -- Kane, A -- Asarkof, N -- Wicks, J -- Guerina, V -- Kellum, J -- Baron, S -- Gintzler, A R -- Donowitz, M -- AM26523/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 19;221(4612):762-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6308760" target="_blank"〉PubMed〈/a〉
    Keywords: Amebiasis/*physiopathology ; Animals ; Biological Transport ; Colon/physiopathology ; Diarrhea/physiopathology ; Disease Models, Animal ; Entamoeba histolytica/*physiology ; Entamoebiasis/*physiopathology ; Ileum/physiopathology ; Intestinal Absorption ; Rabbits ; Rats ; Serotonin/*physiology
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  • 171
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    Organ shortage clouds new transplant era (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-07-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1983 Jul 1;221(4605):32-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857260" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Brain Death ; Female ; Humans ; Male ; Mandatory Programs ; Middle Aged ; Tissue Donors ; *Tissue and Organ Procurement ; *Transplantation ; United States ; tissue are revolutionizing organ transplantation, but the current shortage of ; donated organs is expected to worsen. The reasons for this shortage and possible ; solutions to the problem are discussed briefly, and the ethical and legal ; implications of salvaging organs from brain-dead patients are mentioned. Presumed ; consent laws, already in force in several European countries, would drastically ; increase the number of available organs, but American ethicists are divided over ; a policy permitting automatic use of organs unless a person has left explicit ; instructions to the contrary.
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  • 172
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    Monkey model of Parkinson's disease (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1983 May 13;220(4598):705.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6403987" target="_blank"〉PubMed〈/a〉
    Keywords: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine ; Adult ; Animals ; Cats ; *Disease Models, Animal ; Haplorhini ; Humans ; Male ; Parkinson Disease/physiopathology ; Parkinson Disease, Secondary/*chemically induced ; Pyridines/*adverse effects ; Rats ; Substantia Nigra/drug effects/physiopathology ; Swine
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  • 173
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    New puzzles over estrogen and heart disease (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-06-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1137-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857238" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Cholesterol/blood ; Coronary Disease/*blood ; Estrogens/*blood ; Humans ; Male ; Middle Aged ; Myocardial Infarction/blood ; Risk
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  • 174
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    Serologic evidence of chlamydial and mycoplasmal pharyngitis in adults (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-11-25
    Description: In a study of 763 adult patients we found serologic evidence of infection (a fourfold increase in antibodies) with Chlamydia trachomatis in 20.5 percent of the patients and with Mycoplasma pneumoniae in 10.6 percent, but with group A streptococcus (by culture) in only 9.1 percent. Pharyngitis, the most common problem for which patients seek medical care in the United States, may be caused by nonviral, potentially treatable organisms more often than had been suspected.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Komaroff, A L -- Aronson, M D -- Pass, T M -- Ervin, C T -- Branch, W T Jr -- Schachter, J -- EY 02216/EY/NEI NIH HHS/ -- HS 02063/HS/AHRQ HHS/ -- HS 04066/HS/AHRQ HHS/ -- New York, N.Y. -- Science. 1983 Nov 25;222(4626):927-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6415813" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Antibodies, Bacterial/analysis ; *Chlamydia Infections/diagnosis ; *Chlamydia trachomatis/immunology ; Humans ; Middle Aged ; Mycoplasma Infections/immunology ; Mycoplasma pneumoniae/immunology ; Pharyngitis/*etiology ; Prospective Studies ; Serologic Tests
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 175
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    Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-02-25
    Description: Four persons developed marked parkinsonism after using an illicit drug intravenously. Analysis of the substance injected by two of these patients revealed primarily 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) with trace amounts of 1-methyl-4-phenyl-4-propionoxy-piperidine (MPPP). On the basis of the striking parkinsonian features observed in our patients, and additional pathological data from one previously reported case, it is proposed that this chemical selectively damages cells in the substantia nigra.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Langston, J W -- Ballard, P -- Tetrud, J W -- Irwin, I -- New York, N.Y. -- Science. 1983 Feb 25;219(4587):979-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6823561" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Female ; Humans ; Male ; Meperidine/*analogs & derivatives/metabolism ; Opioid-Related Disorders/*complications ; Parkinson Disease, Secondary/*chemically induced/metabolism ; Substantia Nigra/drug effects
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  • 176
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    A glycolipid antigen associated with Burkitt lymphoma defined by a monoclonal antibody (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-04-29
    Description: The antigen defined by a rat monoclonal antibody directed to a Burkitt lymphoma cell line was identified as globotriaosylceramide [Gal alpha (1 leads to 4)-Gal beta (1 leads to 4)-Glc beta (1 leads to 1)-ceramide]. The antibody demonstrated a strict steric specificity since it did not react with globoisotriaosylceramide [Gal alpha (1 leads to 3)-Gal beta (1 leads to 4)-Glc beta (1 leads to 1)-ceramide], the positional isomer of the antigen associated with the Burkitt lymphoma. Chemical analysis of various Burkitt lymphoma cell lines revealed that the Burkitt lymphoma cells contained more than 100 times as much of the glycolipid antigen as was found in other human lymphoma and leukemia cell lines.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nudelman, E -- Kannagi, R -- Hakomori, S -- Parsons, M -- Lipinski, M -- Wiels, J -- Fellous, M -- Tursz, T -- CA 19224/CA/NCI NIH HHS/ -- CA 20026/CA/NCI NIH HHS/ -- GM 23100/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):509-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836295" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal/*immunology ; Antigens, Neoplasm/*immunology ; Burkitt Lymphoma/*immunology ; Cell Line ; Cell Transformation, Neoplastic/metabolism ; Erythrocytes/immunology ; Globosides/*immunology ; Glycosphingolipids/*immunology ; Humans ; Rabbits ; Rats ; *Trihexosylceramides
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  • 177
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    Visual sustained attention: image degradation produces rapid sensitivity decrement over time (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-04-15
    Description: Perceptual sensitivity to a visual target presented in a random continuous sequence of targets and nontargets decreased rapidly over time when stimuli were highly degraded visually but not when moderately degraded or undegraded. Large declines in sensitivity, independent of changes in response criterion, were found after only 5 minutes of observation. These rapid decrements of sensitivity to degraded targets seem to result from demands on the limited capacity of visual attention.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nuechterlein, K H -- Parasuraman, R -- Jiang, Q -- 784040-29867-5/PHS HHS/ -- MH 30911/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):327-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836276" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; *Attention ; Child ; Discrimination (Psychology) ; Female ; Humans ; Male ; Memory ; Time Factors ; *Visual Perception
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  • 178
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    Insulin antibodies in insulin-dependent diabetics before insulin treatment (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-23
    Description: A sensitive assay was used to measure the binding of iodine-125-labeled insulin in serum obtained from 112 newly diagnosed insulin-dependent diabetics before insulin treatment was initiated. Two groups of nondiabetics served as controls: children with a variety of diseases other than diabetes and nondiabetic siblings of insulin-dependent diabetics. Eighteen of the diabetics were found to have elevated binding and 36 were above the 95th percentile of control values. The insulin-binding protein is precipitated by antibody to human immunoglobulin G, has a displacement curve that is parallel and over the same concentration range as serum from long-standing insulin-dependent diabetics, and elutes from a Sephacryl S-300 column at the position of gamma globulin. These insulin antibodies are present in a large percentage of newly diagnosed, untreated diabetics and may be an immune marker of B-cell damage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Palmer, J P -- Asplin, C M -- Clemons, P -- Lyen, K -- Tatpati, O -- Raghu, P K -- Paquette, T L -- AM17047/AM/NIADDK NIH HHS/ -- AM30780/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1337-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6362005" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Autoantibodies/*analysis ; Child ; Diabetes Mellitus, Type 1/drug therapy/*immunology ; Humans ; Insulin/*immunology/therapeutic use
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  • 179
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    Auditory brainstem potentials in chronic alcoholics (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-03-06
    Description: Auditory brainstem potentials were recorded from abstinent chronic alcoholics and control subjects. The latencies of peaks II, III, IV, and V were significantly delayed in the alcoholic patients compared to control subjects. Brainstem transmission time was longer in alcoholics than in controls. This study provides systematic evidence that chronic alcohol abuse results in brainstem deficits suggesting possible demyelination of auditory tracts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Begleiter, H -- Porjesz, B -- Chou, C L -- AA 02686/AA/NIAAA NIH HHS/ -- New York, N.Y. -- Science. 1981 Mar 6;211(4486):1064-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466379" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Alcoholism/*physiopathology ; Auditory Perception/*physiology ; Brain Stem/*physiopathology ; Evoked Potentials ; Humans ; Male ; Membrane Potentials
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  • 180
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    Language-related potentials specific to human language cortex (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-04-17
    Description: Event-related potentials following silently named object pictures were recorded directly from the exposed left hemisphere of the human cortex at sites whose relation to naming was subsequently established by electrical stimulation mapping. Two simultaneous potential changes are specific to sites where stimulation disrupts naming: slow potentials as premotor sites and focal desynchronization at posterior sites surrounding the Sylvian fissure. These anatomically specific changes are also specific to the task--present with silent naming and absent in a spatial task with the same visual input. Overt speech is also preceded by slow potentials with earliest onset at premotor sites.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fried, I -- Ojemann, G A -- Fetz, E E -- NS 04053/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 17;212(4492):353-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209537" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Cerebral Cortex/*physiology ; Electric Stimulation ; Evoked Potentials ; Female ; Frontal Lobe/physiology ; Humans ; Language/*physiology ; Male ; Middle Aged
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  • 181
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    Measles virus nucleotide sequences: detection by hybridization in situ (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-08
    Description: A tritium-labeled probe that detects measles virus nucleotide sequences was hybridized in situ to cells infected with measles virus and to sections of brain tissue from patients with subacute sclerosing panencephalitis and from patients with multiple sclerosis. The measles virus genome was detected in many cells in subacute sclerosing panencephalitis where this virus would have been missed by methods such as immunofluorescence. Measles virus sequences were also found in two foci in one of four cases of multiple sclerosis. This refined method of hybridization in situ, which can be useful in the search for covert virus infections of man, provides evidence that viruses may be involved in multiple sclerosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Haase, A T -- Ventura, P -- Gibbs, C J Jr -- Tourtellotte, W W -- New York, N.Y. -- Science. 1981 May 8;212(4495):672-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7221554" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; Brain/microbiology ; Child ; Child, Preschool ; Female ; Humans ; Male ; Measles virus/*genetics ; Middle Aged ; Multiple Sclerosis/*microbiology ; Nucleic Acid Hybridization ; RNA, Viral/genetics ; Subacute Sclerosing Panencephalitis/*microbiology
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  • 182
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    Drug found to help heart attack survivors (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1981 Nov 13;214(4522):774-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7027443" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Clinical Trials as Topic ; Humans ; Middle Aged ; Myocardial Infarction/drug therapy/*prevention & control ; Propranolol/adverse effects/*therapeutic use
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  • 183
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    Specific antigen in serum of patients with colon carcinoma (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-04-03
    Description: The binding of monoclonal antibody specific for colon carcinoma was inhibited by serum from patients with adenocarcinoma of the colon but not by serum from patients with other bowel diseases or from healthy volunteers. Of other malignancies studied, serum from two patients with gastric carcinoma and two patients with pancreatic carcinoma also inhibited the specific binding of monoclonal antibody. The levels of carcinoembryonic antigen in these serum samples were not correlated with their levels of binding inhibition. Such monoclonal antibodies may prove useful for the detection of colorectal carcinoma.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koprowski, H -- Herlyn, M -- Steplewski, Z -- Sears, H F -- CA-21124/CA/NCI NIH HHS/ -- RR-05540/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):53-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6163212" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/*immunology ; Adult ; Aged ; Antibodies, Neoplasm/immunology ; Antibody Specificity ; Antigens, Neoplasm/*analysis ; Binding, Competitive ; Carcinoembryonic Antigen/analysis ; Cells, Cultured ; Colonic Neoplasms/*immunology ; Epitopes ; Female ; Humans ; Intestinal Diseases/immunology ; Male ; Middle Aged ; Neoplasms/immunology
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  • 184
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    Circadian rhythms of blood minerals in humans (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-08-07
    Description: Circadian rhythms of ionized calcium and phosphate concentrations have been demonstrated in human blood. A computer-derived model curve representing the 24-hour fluctuations in ionized calcium cannot be correlated consistently with curves for total calcium or phosphate. Knowledge of these circadian rhythms provides a physiological basis for further understanding the interactions between blood minerals and calcium-regulating hormones.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Markowitz, M -- Rotkin, L -- Rosen, J F -- ES-01060-06/ES/NIEHS NIH HHS/ -- RR-53/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1981 Aug 7;213(4508):672-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256269" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Calcium/*blood ; *Circadian Rhythm ; Humans ; Male ; Phosphates/*blood
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  • 185
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    A substance P antagonist, [D-Pro2, D-Trp7,9]SP, inhibits inflammatory responses in the rabbit eye (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-27
    Description: Neurogenic factors released by antidromic nerve stimulation are thought to be in part responsible for the vasodilation and breakdown of the blood-aqueous barrier that follows trauma to the eye. Substance P is one candidate for the mediation of the inflammatory response since it is thought to be a neurotransmitter in sensory afferents and since exogenous substance P is capable of eliciting a response characteristic of inflammation. In rabbits, intravitreal or topical application onto the eye of a specific substance P antagonist, [d-Pro2, D-Trp7,9]SP, inhibited not only the irritant effects of exogenous substance P but also the inflammatory response to a standardized trauma (infrared irradiation of the iris). These observations suggest that substance P, or a related peptide, is a neurogenic mediator of the inflammatory response in the eye.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holmdahl, G -- Hakanson, R -- Leander, S -- Rosell, S -- Folkers, K -- Sundler, F -- New York, N.Y. -- Science. 1981 Nov 27;214(4524):1029-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6171036" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Eye Diseases/*drug therapy ; Inflammation/*drug therapy ; Infrared Rays ; Pupil/drug effects/radiation effects ; Rabbits ; Structure-Activity Relationship ; Substance P/*analogs & derivatives/*antagonists & inhibitors/therapeutic use
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  • 186
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    Circadian variation in the latency of brainstem responses and its relation to body temperature (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-04-17
    Description: The auditory brainstem response varies in a circadian rhythm that is negatively correlated with the circadian rhythm in oral temperature. The auditory brainstem responses and oral temperature were recorded every 3 hours from three healthy male subjects during a 2-day period. The data indicate that a reduction of 1 degree C in oral temperature is associated with an increase of 200 microseconds in the latency of wave V of the auditory brainstem response, and of 160 microseconds in the interval between waves I and V.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, N K -- Donchin, E -- New York, N.Y. -- Science. 1981 Apr 17;212(4492):356-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209538" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Body Temperature ; Brain Stem/*physiology ; *Circadian Rhythm ; Evoked Potentials, Auditory ; Humans ; Male ; Time Factors
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  • 187
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    Globin gene transferred (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-09-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1981 Sep 25;213(4515):1488.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7280666" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *DNA, Recombinant ; Female ; Globins/*genetics ; Male ; Mice ; Plasmids ; Rabbits
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 188
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    Angiogenesis inhibitors link many diseases (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H -- New York, N.Y. -- Science. 1981 Jun 19;212(4501):1374-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233226" target="_blank"〉PubMed〈/a〉
    Keywords: Angiogenesis Inducing Agents/*antagonists & inhibitors ; Angiogenesis Inhibitors ; Animals ; Cattle ; Cornea/blood supply/drug effects ; *Growth Inhibitors ; Humans ; Mice ; Neoplasms/analysis/blood supply/*drug therapy ; Neoplasms, Experimental/*blood supply/*drug therapy ; Proteins/pharmacology/*therapeutic use ; Rabbits ; Retina/analysis
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 189
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    Metabolic mapping of the brain's response to visual stimulation: studies in humans (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-03-27
    Description: These studies demonstrated increasing glucose metabolic rates in the human primary (PVC) and associative (AVC) visual cortex as the complexity of visual scenes increased. The metabolic response of the AVC increased more rapidly with scene complexity than that of the PVC, indicating the greater involvement of the higher order AVC for complex visual interpretations. Increases in local metabolic activity by as much as a factor of 2 above that of control subjects with eyes closed indicate the wide range and metabolic reserve of the visual cortex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Phelps, M E -- Kuhl, D E -- Mazziota, J C -- P0-NS 156540-01/NS/NINDS NIH HHS/ -- R0I-GM-24839-01/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1981 Mar 27;211(4489):1445-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6970412" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Deoxy Sugars/*metabolism ; Deoxyglucose/analogs & derivatives/*metabolism ; Fluorodeoxyglucose F18 ; Humans ; Photic Stimulation ; Tomography, Emission-Computed ; Visual Cortex/*metabolism/physiology/radionuclide imaging
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 190
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    Cognition and long-term use of ganja (Cannabis) (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-24
    Description: Neuropsychological variables and urine cannabinoid metabolites were evaluated in ten subjects born, raised, and educated in the United States and having histories of heavy or prolonged use of cannabis. No impairment of cognitive function was found. Cannabinoid metabolites in excess of 50 nanograms per milliliter were present in the ten urine samples. The tetrahydrocannabinol content of cannabis exceeded 8.0%.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schaeffer, J -- Andrysiak, T -- Ungerleider, J T -- New York, N.Y. -- Science. 1981 Jul 24;213(4506):465-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6972600" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Cannabinoids/*pharmacology/urine ; Cognition/*drug effects ; Female ; Humans ; Male ; Marijuana Abuse/*psychology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 191
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    Dialysis in schizophrenia: a double-blind evaluation (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-03-06
    Description: Eight chronic schizophrenia patients completed a research program consisting of ten weekly sessions of active hemodialysis and ten weekly sessions of sham dialysis in a double-blind design. Previous reports of therapeutic efficacy were not substantiated. None of the patients improved during active dialysis; four patients worsened.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schulz, S C -- van Kammen, D P -- Balow, J E -- Flye, M W -- Bunney, W E Jr -- New York, N.Y. -- Science. 1981 Mar 6;211(4486):1066-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466380" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Double-Blind Method ; Female ; Humans ; Male ; *Renal Dialysis ; Schizophrenia/*therapy ; Sex Factors
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 192
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    The cholinergic hypothesis of geriatric memory dysfunction (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-30
    Description: Biochemical, electrophysiological, and pharmacological evidence supporting a role for cholinergic dysfunction in age-related memory disturbances is critically reviewed. An attempt has been made to identify pseudoissues, resolve certain controversies, and clarify misconceptions that have occurred in the literature. Significant cholinergic dysfunctions occur in the aged and demented central nervous system, relationships between these changes and loss of memory exist, similar memory deficits can be artificially induced by blocking cholinergic mechanisms in young subjects, and under certain tightly controlled conditions reliable memory improvements in aged subjects can be achieved after cholinergic stimulation. Conventional attempts to reduce memory impairments in clinical trials hav not been therapeutically successful, however. Possible explanations for these disappointments are given and directions for future laboratory and clinical studies are suggested.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bartus, R T -- Dean, R L 3rd -- Beer, B -- Lippa, A S -- New York, N.Y. -- Science. 1982 Jul 30;217(4558):408-14.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7046051" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/metabolism ; Adult ; Aged ; Aging ; Alzheimer Disease/physiopathology ; Animals ; Brain Chemistry ; Choline/metabolism ; Choline O-Acetyltransferase/metabolism ; Cognition ; Forecasting ; Humans ; Memory/drug effects ; Memory Disorders/*physiopathology ; Mice ; *Models, Neurological ; Parasympathetic Nervous System/*physiopathology ; Parasympathomimetics/pharmacology ; Phosphatidylcholines/metabolism ; Rats ; Receptors, Muscarinic/metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 193
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    Substance P: a putative sensory transmitter in mammalian autonomic ganglia (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-20
    Description: Repetitive presynaptic stimulation elicited slow membrane depolarization in neurons of inferior mesenteric ganglia from guinea pigs. This response was not blocked by cholinergic antagonists but was specifically and reversibly inhibited by a substance P analog, (D-Pro2, D-Phe7, D-Trp9)-substance P, which also depressed the depolarization induced by exogenously applied substance P. The atropine-sensitive slow excitatory and slow inhibitory postsynaptic potentials evoked in neurons of rabbit superior cervical ganglia were not affected by the substance P analog. These and previous results provide strong support for the hypothesis that substance P or a closely related peptide is the transmitter mediating the slow depolarization. The latter may represent a sensory input from the gastrointestinal tract to neurons of the prevertebral ganglia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jiang, Z -- Dun, N J -- Karczmar, A G -- NS15848/NS/NINDS NIH HHS/ -- RR05368/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 20;217(4561):739-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6179162" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Animals ; Atropine/pharmacology ; Digestive System/physiopathology ; Ganglia, Autonomic/*drug effects ; Ganglia, Sympathetic/drug effects ; Gonadotropin-Releasing Hormone/pharmacology ; Guinea Pigs ; Membrane Potentials/drug effects ; Neurotransmitter Agents ; Peptides/*pharmacology ; Rabbits ; Substance P/analogs & derivatives/*physiology ; Tubocurarine/pharmacology
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  • 194
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    Sex and handedness differences in cerebral blood flow during rest and cognitive activity (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-13
    Description: Cognitive activity resulted in increased flow of blood to the cerebral hemispheres. The increase was greater to the left hemisphere for a verbal task and greater to the right hemisphere for a spatial task. The direction and degree of hemispheric flow asymmetry were influenced by sex and handedness, females having a higher rate of blood flow per unit weight of brain, and females and left-handers having a greater percentage of fast-clearing tissue, presumably gray matter.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gur, R C -- Gur, R E -- Obrist, W D -- Hungerbuhler, J P -- Younkin, D -- Rosen, A D -- Skolnick, B E -- Reivich, M -- MH 30456/MH/NIMH NIH HHS/ -- NS-10939-09/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 13;217(4560):659-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089587" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Brain/metabolism/*physiology ; *Cerebrovascular Circulation ; *Cognition ; Female ; *Functional Laterality ; Humans ; Male ; Metabolic Clearance Rate ; Rest ; *Sex Characteristics
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 195
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    Reduced sympathetic nervous system responsivity associated with the relaxation response (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-08
    Description: Sympathetic nervous system activity was assessed in experimental and control subjects who were exposed to graded orthostatic and isometric stress during monthly hospital visits. After the first session, the experimental subjects practiced a technique that elicited the relaxation response. Their concentrations of plasma norepinephrine during subsequent graded stresses were significantly higher. No such changes were noted in the control group. These results were than replicated in the control group in a crossover experiment. The groups did not differ in their heart rate and blood pressure responses. These observations are consistent with reduced norepinephrine end-organ responsivity after regular elicitation of the relaxation response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hoffman, J W -- Benson, H -- Arns, P A -- Stainbrook, G L -- Landsberg, G L -- Young, J B -- Gill, A -- HL-07374/HL/NHLBI NIH HHS/ -- HL-22727/HL/NHLBI NIH HHS/ -- HL-24084/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 8;215(4529):190-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7031901" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Blood Pressure ; Female ; Heart Rate ; Humans ; Male ; *Muscle Contraction ; *Muscle Relaxation ; Norepinephrine/blood ; *Relaxation Therapy ; Stress, Physiological/physiopathology ; Sympathetic Nervous System/*physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 196
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    Control of vascular contractility by the cardiac pacemaker (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-03-26
    Description: Rhythmic contractile activity, synchronized with pulsatile pressure changes, was recorded from rabbit aorta in vivo. The contractions were locked in frequency to the pulsatile activity of the heart even when the heart was electrically paced to rates as high as 600 cycles per minute; termination of cardiac contractility resulted in their elimination. When the atria and ventricles contracted at different rates, the pulse-synchronized contractions were locked to the atrial rate. Excision of the right atrium, but not the left, resulted in the abolition of pulse-synchronized contractions. It is concluded that common pacemaker controls cardiac and vascular contractility, coordinating events in the two tissues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mangel, A -- Fahim, M -- van Breemen, C -- New York, N.Y. -- Science. 1982 Mar 26;215(4540):1627-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7071582" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aorta/*physiology ; Heart/physiology ; Heart Rate ; Muscle Contraction ; Muscle, Smooth, Vascular/*physiology ; Myocardial Contraction ; Rabbits ; Sinoatrial Node/*physiology
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  • 197
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    Monkey and human pictorial memory scanning (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-18
    Description: A rhesus monkey accurately recognized pictures in a Sternberg memory scanning experiment. When the monkey was tested with pictures that were reused during the same session, the monkey's performance was nearly identical to that of a human subject; this result demonstrates the monkeys are capable of some of the short-term retrieval mechanisms of humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sands, S F -- Wright, A A -- EY-01256/EY/NEI NIH HHS/ -- MH35202/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1982 Jun 18;216(4552):1333-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079768" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Female ; Humans ; Macaca mulatta ; Male ; Memory/*physiology ; Species Specificity ; Time Factors ; *Visual Perception
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 198
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    Tritiated imipramine binding sites are decreased in the frontal cortex of suicides (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-18
    Description: Binding characteristics of tritiated imipramine were determined in the frontal cortex of suicides and well-matched controls. Maximal binding was significantly lower in brains from the suicides. This finding is consistent with reports of decreased tritiated imipramine binding in the platelets of patients diagnosed as having a major affective disorder.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stanley, M -- Virgilio, J -- Gershon, S -- New York, N.Y. -- Science. 1982 Jun 18;216(4552):1337-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079769" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; *Carrier Proteins ; Cerebral Cortex/*metabolism ; Humans ; Imipramine/*metabolism ; Kinetics ; Middle Aged ; Receptors, Drug/*metabolism ; Reference Values ; *Suicide ; Tritium
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  • 199
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    Impulse conduction in the mammalian brain: physiological properties of individual axons monitored for several months (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-11-26
    Description: Microelectrode recordings were used in conjunction with antidromic activation to monitor impulse conduction along individual mammalian cerebral axons for periods of up to 165 days. Approximately half of the axons studied showed a stable conduction velocity and stable aftereffects of impulse activity. The remaining axons showed slow and progressive increases or decreases in conduction velocity overtime. In these latter axons, changes in the magnitude of the aftereffects of impulse conduction were far less pronounced than were changes in axonal conduction velocity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Swadlow, H A -- New York, N.Y. -- Science. 1982 Nov 26;218(4575):911-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7134984" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/*physiology ; Brain/*physiology ; Neural Conduction ; Rabbits ; Time Factors
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 200
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    Decreased nocturnal plasma melatonin peak in patients with estrogen receptor positive breast cancer (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-05-28
    Description: Plasma melatonin concentrations were determined over a period of 24 hours in 20 women with clinical stage I or II breast cancer. In ten of the patients, whose tumors were estrogen receptor positive, the nocturnal increase in plasma melatonin was much lower than that observed in eight control subjects. Women with the lowest peak concentration of melatonin had tumors with the highest concentrations of estrogen receptors. A significant correlation was found between the peak plasma melatonin concentration and the tumor estrogen receptor concentration in 19 of the patients. These data suggest that low nocturnal melatonin concentrations may indicate the presence of estrogen receptor positive breast cancer and could conceivably have etiologic significance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tamarkin, L -- Danforth, D -- Lichter, A -- DeMoss, E -- Cohen, M -- Chabner, B -- Lippman, M -- New York, N.Y. -- Science. 1982 May 28;216(4549):1003-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079745" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Breast Neoplasms/*blood/metabolism/physiopathology ; *Circadian Rhythm ; Humans ; Melatonin/*blood ; Middle Aged ; Pineal Gland/*physiopathology ; Receptors, Estrogen/*metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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