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  • 1
    Publication Date: 1999-06-26
    Description: Regulation of circadian period in humans was thought to differ from that of other species, with the period of the activity rhythm reported to range from 13 to 65 hours (median 25.2 hours) and the period of the body temperature rhythm reported to average 25 hours in adulthood, and to shorten with age. However, those observations were based on studies of humans exposed to light levels sufficient to confound circadian period estimation. Precise estimation of the periods of the endogenous circadian rhythms of melatonin, core body temperature, and cortisol in healthy young and older individuals living in carefully controlled lighting conditions has now revealed that the intrinsic period of the human circadian pacemaker averages 24.18 hours in both age groups, with a tight distribution consistent with other species. These findings have important implications for understanding the pathophysiology of disrupted sleep in older people.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Czeisler, C A -- Duffy, J F -- Shanahan, T L -- Brown, E N -- Mitchell, J F -- Rimmer, D W -- Ronda, J M -- Silva, E J -- Allan, J S -- Emens, J S -- Dijk, D J -- Kronauer, R E -- MO1-RR02635/RR/NCRR NIH HHS/ -- P01-AG09975/AG/NIA NIH HHS/ -- R01-GM53559/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1999 Jun 25;284(5423):2177-81.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Circadian, Neuroendocrine, and Sleep Disorders Section, Division of Endocrinology, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10381883" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Aging/*physiology ; Biological Clocks/genetics/*physiology ; Body Temperature ; Circadian Rhythm/genetics/*physiology ; Darkness ; Female ; Humans ; Hydrocortisone/blood ; Light ; Male ; Melatonin/blood ; Middle Aged ; Sleep
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2001-09-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Czeisler, C A -- Dijk, D J -- Kronauer, R E -- Brown, E N -- Duffy, J F -- Allan, J S -- Shanahan, T L -- Rimmer, D W -- Ronda, J M -- Mitchell, J F -- Silva, E J -- Emens, J S -- New York, N.Y. -- Science. 2000 May 19;288(5469):1174-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Circadian, Neuroendocrine, and Sleep Disorders Section, Division of Endocrinology, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11536927" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Clocks/genetics/*physiology ; Chronobiology Phenomena ; Circadian Rhythm/genetics/*physiology ; Darkness ; Humans ; Sleep
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2002-07-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wright, Kenneth P Jr -- Czeisler, Charles A -- M01-RR02635/RR/NCRR NIH HHS/ -- NIH R01-MH45130/MH/NIMH NIH HHS/ -- T32-DK07529/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2002 Jul 26;297(5581):571.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Suite 438, Boston, MA 02115, USA. kwright@hms.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12142528" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Biological Clocks ; Body Temperature ; *Circadian Rhythm ; Double-Blind Method ; Female ; Humans ; Knee ; *Light ; *Light Signal Transduction ; Male ; Melatonin/blood/secretion ; Sleep ; Supine Position
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2013-05-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Czeisler, Charles A -- England -- Nature. 2013 May 23;497(7450):S13. doi: 10.1038/497S13a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Sleep Medicine, Harvard Medical School, and Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital, in Boston, Massachusetts, USA. charles_czeisler@hms.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23698501" target="_blank"〉PubMed〈/a〉
    Keywords: Circadian Rhythm/physiology/radiation effects ; Electricity/adverse effects ; Humans ; Jet Lag Syndrome/etiology/physiopathology/therapy ; Lighting/*adverse effects ; Melatonin/metabolism/secretion ; Phototherapy ; Sleep Deprivation/epidemiology/*etiology/*physiopathology/therapy ; Suprachiasmatic Nucleus/physiology/radiation effects
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 1989-06-16
    Description: The response of the human circadian pacemaker to light was measured in 45 resetting trials. Each trial consisted of an initial endogenous circadian phase assessment, a three-cycle stimulus which included 5 hours of bright light per cycle, and a final phase assessment. The stimulus induced strong (type 0) resetting, with responses highly dependent on the initial circadian phase of light exposure. The magnitude and direction of the phase shifts were modulated by the timing of exposure to ordinary room light, previously thought to be undetectable by the human pacemaker. The data indicate that the sensitivity of the human circadian pacemaker to light is far greater than previously recognized and have important implications for the therapeutic use of light in the management of disorders of circadian regulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Czeisler, C A -- Kronauer, R E -- Allan, J S -- Duffy, J F -- Jewett, M E -- Brown, E N -- Ronda, J M -- 1-RO1-AG06072/AG/NIA NIH HHS/ -- 2-S07-RR-05950/RR/NCRR NIH HHS/ -- 5-M01-RR00888/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1989 Jun 16;244(4910):1328-33.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2734611" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Circadian Rhythm ; Humans ; Male ; Models, Biological ; *Phototherapy ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 1980-12-12
    Description: Two- to threefold variations in sleep length were observed in 12 subjects living on self-selected schedules in an environment free of time cues. The duration of polygraphically recorded sleep episodes was highly correlated with the circadian phase of the body temperature rhythm at bedtime and not with the length of prior wakefulness. Furthermore, the rate of REM (rapid eye movement) sleep accumulation , REM latency, bedtime selection, and self-rated alertness assessments were also correlated with the body temperature rhythm.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Czeisler, C A -- Weitzman, E d -- Moore-Ede, M C -- Zimmerman, J C -- Knauer, R S -- AG-00792/AG/NIA NIH HHS/ -- GM-07365/GM/NIGMS NIH HHS/ -- MH-28460/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1980 Dec 12;210(4475):1264-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7434029" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Body Temperature ; *Circadian Rhythm ; Humans ; Male ; Middle Aged ; Sleep/*physiology ; Sleep, REM/physiology ; Wakefulness
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 1982-07-30
    Description: Workers on rotating shifts dislike those aspects of their work schedules that violate circadian sleep-wake cycle physiology. Work schedule satisfaction, subjective health estimates, personnel turnover, and worker productivity improve when schedules are introduced that are designed to incorporate circadian principles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Czeisler, C A -- Moore-Ede, M C -- Coleman, R H -- New York, N.Y. -- Science. 1982 Jul 30;217(4558):460-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089576" target="_blank"〉PubMed〈/a〉
    Keywords: *Activity Cycles ; Adult ; Aged ; *Circadian Rhythm ; Health ; Humans ; Job Satisfaction ; Male ; Middle Aged ; *Sleep ; *Work
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1987-01-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Czeisler, C A -- Allan, J S -- New York, N.Y. -- Science. 1987 Jan 9;235(4785):145b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17778615" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
    Publication Date: 1986-08-08
    Description: Human circadian rhythms were once thought to be insensitive to light, with synchronization to the 24-hour day accomplished either through social contacts or the sleep-wake schedule. Yet the demonstration of an intensity-dependent neuroendocrine response to bright light has led to renewed consideration of light as a possible synchronizer of the human circadian pacemaker. In a laboratory study, the output of the circadian pacemaker of an elderly woman was monitored before and after exposure to 4 hours of bright light for seven consecutive evenings, and before and after a control study in ordinary room light while her sleep-wake schedule and social contacts remained unchanged. The exposure to bright light in the evening induced a 6-hour delay shift of her circadian pacemaker, as indicated by recordings of body temperature and cortisol secretion. The unexpected magnitude, rapidity, and stability of the shift challenge existing concepts regarding circadian phase-resetting capacity in man and suggest that exposure to bright light can indeed reset the human circadian pacemaker, which controls daily variations in physiologic, behavioral, and cognitive function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Czeisler, C A -- Allan, J S -- Strogatz, S H -- Ronda, J M -- Sanchez, R -- Rios, C D -- Freitag, W O -- Richardson, G S -- Kronauer, R E -- 1 R01-AG-04912-02/AG/NIA NIH HHS/ -- 1 R01-HD-20174-01/HD/NICHD NIH HHS/ -- AFOSR-83-0309/PHS HHS/ -- etc. -- New York, N.Y. -- Science. 1986 Aug 8;233(4764):667-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3726555" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Body Temperature ; *Circadian Rhythm ; Female ; Humans ; Hydrocortisone/blood ; *Light ; Sleep/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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