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  • Animals  (7,118)
  • Fisheries
  • General Chemistry
  • Inorganic Chemistry
  • 2010-2014  (7,166)
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  • 1
    Publication Date: 2021-05-19
    Description: The genus Ctenochaetus is reportad in the waters of the Colombian Pacific based on two specimens of C. marginatus (Valenciennes) collected in 1993 at Gorgona Island (2°59' N, 78° 12' W). These specimens differ inseveral morphometric characteristics from thosepreviously examined. Such differences appear to be an artifact of the small number of specimens formerly examined and the consequent narrow ranges reportad. We suggest that temperature variability affects the distribution of C. marginatus in the tropical eastern Pacific.
    Description: El género es Ctenochaetus reportad en las aguas del Pacífico colombiano a partir de dos especímenes de C. marginatus (Valenciennes) recogidos en 1993 en la Isla Gorgona (2 ° 59 'N, 78 ° 12' W). Estos ejemplares difieren inseveral características morfométricas de thosepreviously examinados. Estas diferencias parecen ser un artefacto del pequeño número de muestras examinadas anteriormente y reportad los rangos estrechos consecuente. Sugerimos que la variabilidad de la temperatura afecta la distribución de marginatus C en el Pacífico tropical oriental.
    Description: Published
    Keywords: Fisheries ; Fisheries
    Repository Name: AquaDocs
    Type: Journal Contribution
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  • 2
    Publication Date: 2021-05-19
    Description: Over the last decade eutrophication of freshwater artificial reservoirs in Cuba occurred in parallel to oligotrophication of estuarine and coastal waters. These two processes influenced both freshwater and marine fisheries. A dramatic shift in species composition in freshwater fisheries has occurred, from dominance by cichlids (tilapia) to dominance by cyprinids. The high fishery yield from some reservoirs, and shift in species composition, seems related to progressive eutrophication of reservoirs by nutrient subsidies from different anthropogenic activities; particular those related to the size of urban areas within their watersheds. On the other hand, marine landings of estuarine-dependent species declined more significantly than for other groups associated with seagrass beds–coral reefs and oceanic waters. The ratio between catches of estuarine-dependent species and those associated with seagrass beds and coral reefs, decreased significantly over the last 20 years. The decrease in landings was more evident in typical estuarine species, such as shrimps (Litopenaeus schmitti and Farfantopenaeus notialis), mangrove oyster (Crassostrea rhizophorae) and mullets (Mugil spp.). River damming increased during the same period and is significantly correlated with these decreases. It is hypothesized that two different processes acted synergistically, leading to dramatic decreases of several orders of magnitude, in the catches of estuarine species over the last decade: the trapping of nutrients and sediments by river damming, and a drastic reduction in nutrient inputs from land-based sources due to reduced fertilizer use. These are postulated to have affected not only estuarine resources, but also the whole coastal ecosystem.
    Description: Durante la última década, la eutrofización de los embalses artificiales de agua dulce en Cuba se produjo en paralelo a oligotrophication de estuarios y costeras aguas. Estos dos procesos de influencia de agua dulce y la pesca marina. Un cambio dramático en la composición de las especies en la pesca de agua dulce se ha producido, de la dominación de los cíclidos (tilapia) a la dominación de ciprínidos. La alta producción de la pesca de algunos embalses, y el cambio en las especies composición, parece relacionada con la progresiva eutrofización de los embalses de las subvenciones de nutrientes de diferentes actividades antropogénicas, especialmente las relacionado con el tamaño de las zonas urbanas dentro de sus cuencas. Por otro lado, los desembarques de especies marinas de estuario-dependientes disminuyeron significativamente más que para otros grupos asociados con algas marinas Los arrecifes de coral-camas y las aguas oceánicas. La relación entre las capturas de las especies que dependen de los estuarios y las asociadas a las praderas marinas y Los arrecifes de coral, se redujo significativamente en los últimos 20 años. La disminución en los desembarques fue más evidente en especies típicas de estuarios, tales como camarones (Litopenaeus schmitti y Farfantopenaeus notialis), ostra de mangle (Crassostrea rhizophorae) y la lisa (Mugil spp.). El represamiento del Río aumentó durante el mismo período y se correlaciona significativamente con estas disminuciones. Se planteó la hipótesis de que dos procesos diferentes actúan de forma sinérgica, que conduce a una disminución drástica de varios órdenes de magnitud, en las capturas de las especies de estuario en la última década: la captura de nutrientes y sedimentos por represas río, y una reducción drástica de los aportes de nutrientes de fuentes terrestres, debido a la reducción del uso de fertilizantes. Se postula que han afectado no sólo a los recursos estuarinos, sino también todo el ecosistema costero.
    Description: Published
    Description: ríos
    Description: impactos antropogénicos
    Keywords: river ; Fisheries ; Eutrophication
    Repository Name: AquaDocs
    Type: Journal Contribution , Refereed , Article
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  • 3
    Publication Date: 2021-05-19
    Description: Se muestra la evolución de las capturas de las sierras y pintadas, se describen las 3 maneras en que las especies pueden quedar atrapadas en la redes de enmalles, así como también los tipos de redes (deriva, media agua y de fondo).
    Description: Published
    Description: Scomberomorus regalis
    Description: Scomberomorus maculatus
    Description: Scomberomorus cavalla
    Description: spanish mackerel
    Description: king mackerel
    Description: painted mackerel
    Description: enmalle
    Description: arte de pesca
    Keywords: Fisheries ; Artisanal fishing
    Repository Name: AquaDocs
    Type: Journal Contribution , Refereed , Article
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  • 4
    Publication Date: 2021-05-19
    Description: Published
    Description: Mugil curema
    Description: Mugil liza
    Description: Mugil cephalus
    Description: Gerres cinereus
    Description: patao
    Description: coastal lagoons
    Keywords: Mullet fisheries ; Fisheries
    Repository Name: AquaDocs
    Type: Journal Contribution , Refereed , Article
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  • 5
    Publication Date: 2021-05-19
    Description: Production of mangrove oyster (Crassostrea rhizophorae Guilding, 1828), north of Villa Clara, Cuba Province, tends to decline since 1980, accentuating from 2003 on. Despite regulations to protect the resource, minimum legal size and catch closures, the year 2008 presents the landing smaller volumes of the past 50 years. An analysis of the variability of catches in relation to natural and human factors, allows for precipitating causes of low productivity of this fishery resource; between the most representatives are expanding storage capacity of river water, salinity increment, the increase in frequency and intensity of hurricanes and the mismanagement of the extraction of oyster.
    Description: La producción de ostión de mangle (Crassostrea rhizophorae, Guilding, 1828), al norte de la provincia de Villa Clara, Cuba, tiende a la disminución desde de 1980, acentuándose a partir del año 2003. A pesar de regulaciones para la protección del recurso, talla mínima legal y vedas de captura, el año 2008 presenta los menores volúmenes de desembarque de los últimos 50 años. Un análisis de la variabilidad de las capturas, en relación con factores naturales y antrópicos, permite establecer causas desencadenantes de la baja productividad de este recurso pesquero; las más representativas son, la ampliación en la capacidad de embalse de aguas fluviales, aumentos de la salinidad, el incremento en la frecuencia e intensidad de los huracanes y un manejo inadecuado de la actividad extractiva de ostión.
    Description: Crassostrea rhizophorae, Cuba
    Keywords: Fisheries ; Environmental effects ; Fisheries
    Repository Name: AquaDocs
    Type: Preprint
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  • 6
    Publication Date: 2021-05-19
    Description: Las capturas de langosta espinosa Panulirus argus (Latreille, 1804) en Cuba alcanzaron sus mayores volúmenes en la década de 1980 con un promedio anual de 11565 ton. En la década de 1990, la captura descendió a un promedio de 9327 ton, lo cual se ha visto agudizado entre 2000 y 2007 con un promedio de 6262 ton y una mayor variabilidad de las capturas, a pesar de un perfeccionamiento del sistema de manejo pesquero dado por: la disminución del esfuerzo pesquero y de la tasa de mortalidad por pesca desde 1999, el aumento del período de veda desde 2001 y el incremento gradual de la talla mínima legal de captura a partir de 2004. Los análisis más recientes sobre el estado de esta pesquería fueron presentados en el Quinto Taller Regional sobre la Evaluación y la Ordenación de la Langosta Común del Caribe en septiembre 2006 (Puga et al, 2006; FAO, 2007), donde se reconoció por la comunidad científica especializada que la pesquería de langosta cubana se encontraba bien manejada y plenamente explotada (no sobre- explotada) y se concluyó que además de la mortalidad por pesca, otros factores ajenos al sector pesquero estaban produciendo afectaciones en la abundancia del recurso, al causar daños al hábitat 1 en zonas de cría, influyendo negativamente por esta vía sobre el reclutamiento y la producción de langostas. Entre estos aspectos para Cuba se señalaron: la mayor frecuencia e intensidad de huracanes durante el último decenio, el desarrollo de las zonas costeras, la construcción de presas en las cuencas de captación de los ríos y de carreteras en el Archipiélago Sabana-Camagüey comunicando la isla principal con los cayos y los cayos entre si (pedraplenes).
    Description: Published
    Keywords: Fisheries ; Lobster fisheries ; Fisheries ; Environment management ; Recruitment ; Coastal zone management
    Repository Name: AquaDocs
    Type: Book Section
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  • 7
    Publication Date: 2021-05-19
    Description: Se efectúa un estudio de la fauna acompañante del Mero, Epinephelus morio, en la pesquería con palangre de fondo del Banco de Campeche, México, durante el periodo 1987-2009. En la investigación se consideró información de 32 cruceros de investigación realizados en la etapa como parte del convenio pesquero firmado por Cuba y México para la evaluación sistemática del recurso. Se determinó la composición por especie y talla de las capturas, sus variaciones en la abundancia relativa, estructura de tallas, así como el índice de diversidad de Brillouin, la riqueza de especies (Margalef, 1980), la dominancia numérica y la constancia, estas ultimas valoradas según el esquema propuesto por Bodenheimer (1955). Se encontró que la fauna acompáñate de E. morio esta representada por 69 especies, agrupadas en 3 clases y 12 órdenes. De ellos, el orden mejor representado lo constituyó Perciformes con las familias Serranidae, Lutjanidae, Scombridae, Carangidae y Haemulidae como las más abundantes en número. Dentro de estas, dominaron las especies L. campechanus y O. chrysurus, apreciándose que las entidades mejor representadas son, L. campechanus (100%), O. chrysurus (96,87%) y M. bonaci (73,2%). Los largos medios observados se encontraron por encima de las tallas de primera maduración reportadas en la literatura. Sólo E. nigritus y L. analis presentaron individuos inmaduros. Se reportan tallas máximas superiores a las reportadas en la bibliografía en M. interstitiaslis (150cm), M. bonací (155cm) y E. nigritus (125cm). Se determinó que el rendimiento (cpue) y la diversidad de la fauna acompañante poseen una relación inversa con la disminución de la biomasa de mero. Por su parte, la diversidad y riqueza de especie presentaron sus mayores valores concordando con las temporadas de lluvias.
    Description: Mero Epinephelus morio, fauna acompañante, Banco de Campeche, México,
    Keywords: Fisheries ; Fauna ; Fisheries ; Fauna
    Repository Name: AquaDocs
    Type: Preprint
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  • 8
    Publication Date: 2021-05-19
    Description: Se presentan los resultados de monitoreo de las poblaciones comerciales de cobo en el área comprendida entre los cayos El Cabezo y Boca de Sagua (220 49`N--230 04`N y los 790 35W—800 07´ `W), plataforma Norte de la Provincia de Villa Clara. A partir de los resultados de las densidades de individuos como índice de la abundancia y la estructura poblacional encontrada, se propone un potencial de captura de 104 TM (peso entero). Además, se definen las medidas de manejo para el uso sostenible del recurso Eustrombus gigas en esta zona. El aprovechamiento en carne desembarcada (Eviscerada y sin manto) para individuos adultos con talla comercial se obtiene por un factor de 0,074 (7,4%) del peso entero, que representa 7,7 TM. Se excluye el área protegida desde Las Picúas hasta Cayo Cristo.
    Description: cobo (Eustrombus gigas), Caibarién, Villa Clara
    Keywords: Monitoring ; Fisheries management ; Fisheries
    Repository Name: AquaDocs
    Type: Preprint
    Format: 4
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  • 9
    Publication Date: 2021-05-19
    Description: La Commission Sous Régionale des Pêches (CSRP), qui est un organisme intergouvernemental de coopération halieutique dont l’objectif global est l’harmonisation à long terme, des politiques des pays membres en matière de préservation, de conservation et d'exploitation durable de leurs ressources halieutiques et le renforcement de leur coopération au profit du bien-être de leurs populations respectives, a obtenu par l’intermédiaire de la Banque mondiale, un Don du Fonds pour l’Environnement Mondial (FEM) et du Gouvernement du Japon, pour la préparation d’un Projet Régional des Pêches en Afrique de l’Ouest (PRAO) pour trouver une solution à la problématique susvisée. Ce projet implique 9 pays côtiers: la Mauritanie, le Cap Vert, le Sénégal, la Gambie, la Guinée Bissau, la Guinée, le Sierra Léone (Etats membres de la CSRP), ainsi que le Libéria et le Ghana. Le PRAO comprend trois composantes : (1) Bonne Gouvernance et Gestion Durable des Pêches ; (2) Réduction de la Pêche Illicite ; (3) Augmentation de la Contribution des Ressources Halieutiques dans les Economies Locales (incluant la réalisation d’infrastructures et équipements dans les pêcheries). Certes, les activités prévues dans le cadre du PRAO sont pressenties pour contribuer au développement du secteur de la pêche dans les pays ciblés et apporter des bénéfices aux populations locales. Toutefois, elles pourraient engendrer dans certains cas des effets négatifs aux niveaux environnemental et social (notamment celles prévues dans la composante 3), si des mesures adéquates ne sont pas prises au préalable. Afin de minimiser ces effets défavorables, il a été requis l’élaboration de la présente Evaluation Environnementale et Sociale (EES).
    Description: Commission Sous Régionale des Pêches (CSRP)
    Description: Published
    Description: ressource marine, ressource côtière, politique de pêhce, environnement, qualité des produits, pollution, gestion des pêches,aire marine protégée
    Keywords: Marine resources ; Fisheries ; Fishery management ; Coastal fisheries ; Quality assurance ; Environment management ; Marine resources ; Fisheries ; Fishery management ; Coastal fisheries ; Coastal zone ; Fishery regulations ; Fishery economics ; Marine pollution ; Quality control ; Illegal fishing ; Fishery organizations ; Quality assurance
    Repository Name: AquaDocs
    Type: Report
    Format: 111
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  • 10
    Publication Date: 2021-05-19
    Description: Ce travail représente une contribution à l'étude de l'activité de pêche hauturière dans le gouvernorat de Médenine, particulièrement, au niveau du port de Zarzis ; durant la période (juin 2005-juin 2006). Il consiste à réaliser, grâce à des enquêtes menées au port, deux types d'analyses : une analyse quantitative afin de déterminer les débarquements saisonniers moyens des espèces les plus débarquées par la pêche hauturière et une analyse qualitative pour établir les structures démographiques des espèces les plus exploitées dans la région. Les résultats obtenus ont montré que, durant la période d'étude, les principales espèces débarquées par la pêche hauturière sont la sardinelle, le maquereau, le saurel, le rouget blanc, le pageot, la thonine, la seiche et la crevette royale. En examinant les débarquements saisonniers moyens des espèces les plus débarquées par type de pêche, nous avons remarqué que deux ou trois espèces dominent pour chaque saison. De plus, l'analyse des structures démographique des apports a montré que la majorité des individus débarqués sont matures, à l’exception du maquereau dont les captures sont constituées d’individus immatures, surtout pendant les saisons d’été et d’automne.
    Description: This work represents a contribution to the study of the offshore fishing activity in the governorate of Medenine, particularly at the port of Zarzis, during the period (june 2005-june 2006. It is to realize, through surveys conducted at the port, two types of analyzes: a quantitative analysis to determine the average seasonal landings of most landed species by fishing offshore units and qualitative analysis to determine the demographic structure of the most exploited species in the region. The obtained results showed that during the period of study, the main landed species by offshore fishing are sardinella, mackerel, horse mackerel, white mullet, sea bream, skipjack tuna, cuttlefish and the caramote prawn. By examining the average seasonal landings of the most landed species, we noticed that, for each season, two or three species dominate. Furthermore, analysis of demographic structures of the landings showed that the majority of landed individuals are mature, with the exception of mackerel catches which are composed of immature individuals, especially during the seasons of summer and autumn.
    Description: Published
    Description: analyse qualitative
    Description: pêche hauturière
    Keywords: Quality analysis ; Offshore ; Fisheries
    Repository Name: AquaDocs
    Type: Proceedings Paper , Refereed , Meeting abstract
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  • 11
    Publication Date: 2021-05-19
    Description: El presente artículo da una descripción detallada de la elaboración y del "curado" de cuerdas de curricán, utilizadas anteriormente para la pesca en Taganga, un pueblo pescador en la costa norte de Colombia. Antes del "curado", estas cuerdas de fibras de algodón y de fabricación industrial, eran o destorcidas o torcidas a mano nuevamente, o tensionadas y envueltas con una cuerda más delgada del mismo material. El "curado" que siguió a estas operaciones se efectuó tanto en una cocción de corteza de las raíces zanconas de mangle, y/o por medio de un frote de estas cuerdas con los hypocotylos del mismo árbol (Rhizophora manglr). Por medio de las técnicas aquí descritas, los pescadores aspiraban a aumentar la resistencia de sus aparejos de pesca en el agua de mar.
    Description: The present paper gives a detailed description of the elaboration and curing of curricán Unes, formerly used as fishing lines in Taganga, a small fishing village on the northem coast of Colombia. These lines, made of cotton fibers and produced industrially, were disassembled and then retwisted by hand, or tightened and then carefully covered with a thinner string of the same material. The curing {"curado") that followed these operations was achieved by immersion of the lines into a boiled infusión of the bark of the prop roots of mangroves (Rhizophora mangle) and/or a rinsing with the hypocotyls of the same trees. By means of the techniques mentioned, the fishermen sought to improve the resistance of their fishing gear to sea water.
    Description: Published
    Keywords: Fisheries ; Fishing ; Gear construction ; Fisheries ; Fishing
    Repository Name: AquaDocs
    Type: Journal Contribution
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  • 12
    Publication Date: 2021-05-19
    Description: During a 3 week study, a total of 55 individuals of the redlip blenny (Ophioblennius atlanticus) were observed for at least two 15-minute periods, and several for ten of such periods. The sizes of their territories were estimated, the color pattern of each specimen an intra and interspecific interactions were recorded. The mean territory size of the redlip blenny in the study area appeared to be greater than that of these blennies studied in Curacao and Barbados by NURSALL (1977), the difference reflecting perhaps different methods of identifying the territories or a lower density of O. atlanticus in the Santa Marta área. Territories did not appear to be as consistently defended at the study area as at Barbados/Curacao and our impression ¡s that individuals holding large territories are less likely to defend their borders. It seems possible that light colored individuals are protected by their coloration from attack by dark colored territory owners. In territorial defense the redlip blennies grabbed each other tighthy by the mouth and struggled in this position repeatedly for about 15 seconds. Interspecific antagonism was common in the present study, the redlip blennics defended their territory frequently against Eupomacentrus dorsopunicans or E. partitus.
    Description: Durante un estudio de tres semanas, un total de 5 i individuos del bií'nido Ojih'toblcnnius atlnniicur. fueron observados por lo menos durante dos períodos de 1 í minutos para cada individuo y en algunos casos hasta por 10 de estos periodos. Se estimó el área de sus respectivos territorios y se tomó notí de los patrones de coloración de cada espécimen y de las relaciones intra e interespecificas de ellos. El tamaño promedio del territorio de estos blénidos resultó ser mayor que el de los respectivos territorios estudiados por NURSALL (1977) en Curacao y Barbados. Esta diferencia posiblemente se debe a un método diferente de definir los territorios o refleja una densidad menor de la población de O. aílanticus en Santa Marta, Los territorios del área fueron defendidos con menor intensidad a como lo fueron los de Barbados/ Curacao y es nuestra impresión que individuos ocupando un territorio extenso tienden a defender sus límites en menor grado. El color claro de algunos individuos probablemente los protege de agresiones por parte de individuos de color oscuro. En el acto de defensa territorial intraespecífica, los blénidos se agarran por sus bocas y se sacuden mutuamente durante aproximadamente 15 segundos , pudiéndose repetir esti varias veces. Con frecuencia se observarondefensas de los territorios dirigidas hacia los peces doncella Eupomacentrus dorsopunicnas y E. partitus.
    Description: Published
    Keywords: Fisheries ; Biology ; Fisheries ; Biology
    Repository Name: AquaDocs
    Type: Journal Contribution
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  • 13
    Publication Date: 2021-05-19
    Description: Se registra por primera vez el fenómeno de albinismo en la familia de peces Muraenesocidae, con base en dos ejemplares de Cynoponticits savanna capturados en la Península de la Guajira. Caribe colombiano.
    Description: The phenomenom of albinism is reported for the first time in che fish family Muraenesocidae. Two anomalous individuals of Cynoponticus savanna were collected from the Guajira Península colombian Caribbean.
    Description: Published
    Keywords: Fisheries ; Albinism ; Fisheries ; Albinism ; New records
    Repository Name: AquaDocs
    Type: Journal Contribution
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  • 14
    Publication Date: 2021-05-19
    Description: Se muestran las capturas históricas de la biajaiba (1935-2000), la evolución de las capturas del pargo (una de las especies de mayor interés económico en Cuba). Se evalúa la utilización de éstas artes de pesca en especies comerciales y su implicación con daños al medio ambiente. Se tiene en cuenta que los pargos criollos, la biajaiba y el caballerote representan el 20 % de las capturas.
    Description: Published
    Description: pesquería artesanal
    Description: cubera
    Description: cherna criolla
    Description: pesca del alto
    Description: pargo
    Description: rabirrubia
    Description: caballerote
    Description: biajaiba
    Keywords: Fisheries ; Artisanal fishing
    Repository Name: AquaDocs
    Type: Journal Contribution , Non-Refereed , Article
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  • 15
    Publication Date: 2021-05-19
    Description: Se ha estudiado la variación anual de la condición de la lisa Mugil incilis Hancock en la Ciénaga Grande de Santa Marta (CGSM), la mayor laguna costera del Caribe Colombiano, haciendo énfasis en la influencia ejercida por factores ambientales como la salinidad, la temperatura y la transparencia de las aguas sobre la condición de esta especie de Mugilidae. Las diferencias estacionales observadas en la condición de M. incilis están evidentemente relacionadas con su desarrollo gonadal y dependen de la disponibilidad de alimento. La dieta de M. incilis se basa en detritos y su suministro de alimento parece ser muy afectado por el aporte fluvial a la CGSM, el cual es también responsable de los cambios en la salinidad de la laguna, esto explica la relación inversa (r = -0.82) hallada entre la salinidad y la condición de M. incilis expresada por C = 0.9949 - 0.0057 S(°/oo). La variación anual de la salinidad sigue un patrón rítmico de cambios estacionales, no precisamente "in situ", sino en regiones continentales distantes: las cabeceras de los tributarios de la CGSM. Estas lisas desovan en aguas del Caribe adyacente a la CGSM y su período de migración (dic-marzo) comienza con su mejor condición física, y retornan a sus áreas de alimentación en la CGSM 2 a 4 semanas después, hasta el final de la migración, con su condición mínima ya que al parecer estas lisas no se alimentan durante su migración de desove. No se observaron cambios relacionados con las variaciones de la temperatura. Las aguas más turbias coincidieron con los sitios de alimentación de M. incilis.
    Description: The annual variation in condition of the mullet Mugil incilis Hancock has been studied in the Ciénaga Grande de Santa Marta (CGSM). The largest coastal lagoon on the Colombian Caribbean, with emphasis on the influence of such environmental factors as salinity, temperature and transparence of the waters on the condition of this species of Mugilidae. Seasonal differences observed in condition of M. incilis are evidently related to gonadal development and depend on food availability. The diet of M, incilis is based on detritus and its food supply seems to be very influenced by river discharge which also accounts for the salinity changes in the lagoon. this explains the in verse correlation (r = -0.82) found between salinity and condition of the mullets expressed as C = 0.9949 - 0.0057 S (°/oo). Annual salinity variation follows a rhythmic pattern of seasonal changes. not precisely "in situ", but in distant continental regions: the headwaters of the tributarles of the CGSM. These mullets spawn in Caribbean waters adjacent to the CGSM and their migración period (Dec-March) begins with their best physical condición, returning to their feeding áreas in the CGSM 2 or 4 weeks lacer, until the end of the migración, with their lowest condition since these mullets apparently do not feed at all during the spawning migration. No change related to temperature variations was observed. and turbid waters were the rule in M. incilis feeding sites.
    Description: Published
    Description: Mugil incilis
    Keywords: Fisheries ; Estuaries ; Ecology ; Coastal lagoons ; Fishery biology ; Fisheries ; Coastal lagoons ; Estuaries ; Fishery biology ; Ecology
    Repository Name: AquaDocs
    Type: Journal Contribution
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  • 16
    Publication Date: 2021-05-19
    Description: Un análisis de los datos arqueológicos e históricos sobre la pesca en Cuba muestra que el impacto de la población aborigen sobre los recursos pesqueros no fue significativo debido a su baja densidad poblacional y a las tecnologías de pesca. El interés por el oro, el tamaño de la población, las limitaciones tecnológicas para la pesca y preservación de las capturas así como las preferencias dietéticas de los españoles todas indican que la pesca tampoco fue una actividad económica importante durante los tres siglos que siguieron a la llegada de Colón. Las preferencias por la carne de res y el bacalao salado y la baja tasa de crecimiento poblacional durante el período colonial determinaron que la mayor parte de los recursos pesqueros, con la excepción del manatí y las tortugas marinas, permanecieran prácticamente inexplorados durante varios siglos después de la Conquista. Los datos estadísticos e históricos revelan que la pesca experimentó un rápido crecimiento desde 1950 y este patrón parece ser una característica común en el Caribe así como en otras partes del mundo. Las presiones sobre la vida marina fueron más evidentes en la segunda mitad del siglo xx cuando el crecimiento poblacional, las mejoras tecnológicas y las demandas del mercado aceleraron el sector pesquero así como la urbanización en la mayoría de los países del caribe.
    Description: Published
    Keywords: Integrated management ; Fisheries
    Repository Name: AquaDocs
    Type: Proceedings Paper , Refereed , Article
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  • 17
    Publication Date: 2021-05-19
    Description: Se describen y se ilustran seis especies de parásitos pertenecientes a la familia Acanthocolpidae encontradas en 19 especies de peces en su mayoría de considerable importancia económica. El estudio taxonómico de estos parásitos se realizó en la Ciénaga Grande de Santa Marta, al norte de Colombia, desde Enero de 1978 hasta Junio de 1979.
    Description: A taxonomic study for parasites found in 19 mostly economically important fish species was carried out in ihe Ciénaga Grande de Santa Marta (Northern Colombia) from January 1978 uritil June 1979. Six species of fish parasites belonging to the family Acanthocolpidae are described and illustrated herein.
    Description: Published
    Keywords: Fisheries ; Ecology ; Parasites ; Parasites ; Fisheries ; Ecology
    Repository Name: AquaDocs
    Type: Journal Contribution
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  • 18
    Publication Date: 2021-05-19
    Description: En 1987, se inicia un programa de muestreos biológicos del calamar argentino ///ex argentinas a bordo de barcos comerciales de la flota cubana de pesca que operan en la plataforma patagónica. La talla de los organismos para ambos sexos presenta un comportamiento estratificado por profundidades, los ejemplares de mayor tamaño se encuentran a profundidades superiores y viceversa, lo cual se ajusta a una recta de regresión (r2 = 0.88; a = 0.05). Las hembras alcanzaron largos promedio del manto superior a los machos, incrementándose la presencia de machos en las capturas desde enero a abril. Se estimaron los largos promedio de primera maduración, como 20.5 y 26.5 cm de largo del manto para machos y hembras respectivamente. Se observó un aumento de la proporción de individuos maduros de febrero a abril, haciéndose más marcado este fenómeno en los machos, que en su mayoría presentaban abundantes espermatóforos en el saco. Se obtuvo la relación largo-peso para hembras y machos y para la combinación de ambos sexos.
    Description: In 1987 a program for the biological sampling of squid ///ex argentinas, was begun on board of a fishing ship belonging to the Cuban Fisheries-Fleet, wich operates in the Patagonian Shelf. The lengths of both sexes presented a estratified pattern with individuals of larger size found in higher depths and viceversa; this pattern is adjusted to a regression line (r2 = 0.88; a = 0.05). Pernales reached average length larger (han males and the rate of males in catches increased from january to april. The first maturation average length was estimated about 20.5 cm for males and 26.5 cm for females. An increase of the rate of mature individuals was observed between february and april emphazasing ¡n males which showed abundant espermatophores in the sac.
    Description: Published
    Description: squid, Flota Cubana
    Keywords: Fisheries ; Squid culture ; Biological charts ; Biological data ; Fisheries ; Squid culture
    Repository Name: AquaDocs
    Type: Journal Contribution
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  • 19
    Publication Date: 2021-05-19
    Description: A yield per recruit model has been used to compare the effects of mesh size increment on the yields and revenues of the fisheries of Cameroon under two different cases. Case 1 assumes the commercial fishery to move from the exploitation of three age-groups to two age-groups with no interactions with the artisanal fishery, whereas Case 2 takes into account these interactions. The difference in the percentage increase of yield per recruit between case 1 and case 2 is 61% at current fishing (46% and 18% yield per recruit increment in cases 1 and 2 respectively). The usually accepted long-term yield per recruit increment with increase of age at first capture (with a single non-interacting fisheries) is, in this case, cancelled out. However, the revenues increase by 72% and 63% in cases 1 and 2 respectively. Therefore the economic approach, compared with purely biological analyses, is more convincing. In general, as fisheries always interact, a single-fishery management approach should not be the rule as it is at present; management strategies should consider interactions between different fisheries and be based on their economic performances and not, as said earlier, on purely biological considerations. This is because a biological approach to fisheries management will, at best, be modified by economic factors, or, at worst, be ignored totally in favour of economic policies.
    Description: Published
    Keywords: Biology ; Fisheries ; Biological interaction ; Sciaenidae ; Fisheries development ; Fishery management ; Yield/recruit ; Commercial fisheries ; Artisanal fishing
    Repository Name: AquaDocs
    Type: Journal Contribution , Refereed , Article
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  • 20
    Publication Date: 2021-05-19
    Description: La pêche au Sénégal joue un rôle économique et social très important par une contribution globale de près de 11% du PIB primaire et 2,3% du PIB total. Elle occupe de façon directe et indirecte environ 600 000 personnes, soit près de 17% de la population active selon la DP M. Cependant ces dernières décennies, les études ont montré que le secteur traverse une crise aiguë se traduisant par une raréfaction croissante des ressources, notamment les espèces nobles qui ont une forte valeur commerciale. Cette crise est due entre autres à une surexploitation de ces ressources qui est le résultat d’un manque de maîtrise de l’effort de pêche surtout pour les pêcheries artisanales (80% des débarquements et plus de 60% des approvisionnements des industries de la place) au regard du volume de ressources disponibles. Ce manque de maîtrise est dû essentiellement par un défaut du suivi contrôle et surveillance au niveau de la pêche artisanale par l’Etat, qui n’a pas les moyens humains et matériels pour appliquer des mesures de gestion, qui pour la plupart ne sont pas adaptées aux réalités des acteurs à la base. L’objet de cette étude est d’analyser une nouvelle approche axée sur la surveillance participative basée sur l’émergence d’initiatives locales de cogestion au niveau des quatre (04) sites du programme GIRMaC que sont ; Ouakam, Ngaparou, Foundiougne et Bétenty. Il ressort de cette étude que : • Le secteur de la pêche traverse une crise aiguë due principalement selon les acteurs à un défaut de suivi, contrôle et surveillance tel que appliqué actuellement ; • L’approche de cogestion avec des bases juridiques cohérentes, comme le propose le programme GIRMaC peut être un moyen viable pour solutionner à la crise que traverse la pêche ; • D’une part le système Suivi Contrôle et Surveillance coûte cher, d’autre part que ces coûts sont fortement amoindris lorsque les acteurs participent à l’effort de surveillance, par une démarche de surveillance participative en cogestion.
    Description: Président : Omar Thiom THIAW, Professeur UCAD Membres : • Niokhor DIOUF, Chercheur IUPA. • Luis Tito Morais, Chercheur IRD Dakar. • Djiby THIAM, Chercheur GIRMac
    Description: Published
    Description: surveillance; contrôle; cogestion; effort de pêche; pêcherie; surexploitation; biodiversité; pêche artisanale
    Keywords: Ocean surveillance ; Ecosystem management ; Fishing effort ; Overexploitation ; Biodiversity ; Artisanal fishing ; Fisheries
    Repository Name: AquaDocs
    Type: Theses and Dissertations , Master thesis
    Format: 87
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  • 21
    Publication Date: 2021-01-30
    Description: The first meeting of the South West Indian Ocean EAF Regional Task Group (RTG) was held in Mombasa, Kenya, from 27 to 30 January 2009, together with an ecological risk assessment methodology workshop. It was attended by 20 partic ipants from the South West Indian Ocean (SWIO) countries, the South West Indian Ocean Fisheries Project (SWIOFP), the Agulhas and Somali Currents Large Marine Ecosystems (ASCLME) project, the Scientific Committee of the South West Indian Ocean Fisheries Commission, the United Nations Environment Programme (UNEP)/Nairobi Convention Implementation Unit, the African Union Commission and FAO. The RTG is an implementation structure under the EAF-Nansen project GCP/INT/003/NOR and serves as the forum for training in ecological risk assessment that is the methodology used for the identification and prioritization of issues requiring management attention. The main objectives of the meeting and workshop we re to discuss and facilitate key processes and activities for the implementation of the ecosystem approach to fisheries management in the South West Indian Ocean region including the modalities for the formation and functioning of the RTG and National Task Groups (NTGs). It was explained that, to be able to achieve the objectives of implementing an ecosystem approach to fisheries at the national level, certain key structures have to be in place including the NTG with representatives of key stakeholders in a given fishery and that would take the lead in the process. An overview of the key concepts and process of the ecological risk assessment methodology were clarified. Participants were also introduced to the preparation of EAF baseline reports to be used as initial input for the work on ecosystems approach to fisheries. It was explained that the preparation of the report is to be led by national and regional experts and overseen by the NTG. For the exercises the participants worked in three subgroups formed during the meeting with each group selecting a chairman who moderate d the discussions and a rapporteur. The participants expressed satisfaction with the development of a communication strategy for the project and especially with the participatory approach used.
    Description: FAO, NORAD, Institute of Marine Research
    Description: Published
    Description: National task groups
    Description: Regional task groups
    Description: Ecosystem Approach to Fisheries
    Keywords: Ecosystems ; Fisheries ; Ecosystems ; Fishery resources ; Fisheries management
    Repository Name: AquaDocs
    Type: Report , Non-Refereed
    Format: 36
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  • 22
    Publication Date: 2021-05-19
    Description: Published
    Description: espéces pélagiques
    Description: sardine
    Description: pêche industrielle
    Keywords: Fisheries ; Pelagic fisheries ; Industrial fish ; Fish products ; Fishing industry ; Fishing fleet
    Repository Name: AquaDocs
    Type: Journal Contribution , Non-Refereed , Article
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  • 23
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    Nigerian Institute for Oceanography and Marine Research | Lagos, Nigeria
    Publication Date: 2021-01-30
    Description: Published
    Description: Fisheries newsletter
    Keywords: Fisheries ; Marine sciences ; Fisheries literature
    Repository Name: AquaDocs
    Type: Report , Non-Refereed
    Format: 30pp.
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  • 24
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    Nigerian Institute for Oceanography and Marine Research | Lagos, Nigeria
    Publication Date: 2021-01-30
    Description: Published
    Description: Fisheries newsletter
    Keywords: Fisheries ; Marine sciences ; Fisheries literature
    Repository Name: AquaDocs
    Type: Report , Non-Refereed
    Format: 34pp.
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  • 25
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    Nigerian Institute for Oceanography and Marine Research | Lagos, Nigeria,
    Publication Date: 2021-01-30
    Description: Published
    Description: Fisheries newsletter
    Keywords: Fisheries ; Fisheries literature
    Repository Name: AquaDocs
    Type: Report , Non-Refereed
    Format: 11pp.
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  • 26
    Publication Date: 2021-05-19
    Description: Unpublished
    Description: conservation
    Description: chaine froide
    Description: poisson
    Keywords: Food conservation ; Fisheries ; Fish conversion ; Conservation (fishery products) ; Glass ; Fisheries
    Repository Name: AquaDocs
    Type: Journal Contribution , Non-Refereed , Article
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  • 27
    Publication Date: 2021-05-19
    Description: Published
    Description: Pêche
    Description: Senneur
    Keywords: Seining ; Fisheries ; Fisheries ; Seiners
    Repository Name: AquaDocs
    Type: Journal Contribution , Refereed , Article
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  • 28
    Publication Date: 2021-05-19
    Description: ACDI;CRDI; République Française, Ministère des Affaires Etrangéres; CDE; Enda Graf Sahel;
    Description: Conseil Info MPEA, Projer d'Accés à l'information et au Conseil pour les microet petites entreprises agroalimentaires; Projet d'Appui aux Opérateurs/trices de l'Agroalimentaires (PAOA); Cintech Agroalimentaire; Groupe de Recherche et d'Echanges Technologiques (GRET); Enda GRaf Sahel; SNC-LAVALIN International
    Description: Published
    Description: transformation; transformation artisanale; échantillonage; collecte de données; commercialisation
    Keywords: Processing fishery products ; Biological sampling ; Data collections ; Marketing and distribution ; Fisheries
    Repository Name: AquaDocs
    Type: Theses and Dissertations , Master thesis
    Format: 41
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  • 29
    Publication Date: 2021-05-19
    Description: Français - Les traits essentiels de la côte sénégalaise, repères historiques de la pêche, communautés de pêcheurs, caractéristiques des flottes et modes d’accès à la ressource et d’interaction sont analysés. Les caractéristiques, tendances décroissantes de l’abondance,niveaux d’exploitation, mesures d’aménagement, relations interspécifiques, changements potentiels et sources de variation des stocks démersaux côtiers sont précisés. Les notions de tactiques et stratégies de pêche sont passées en revue, conceptualisées puis étudiées.Le modèle «Dynamique Conjointe Exploitation Ressource» utilisé repose sur la définition de 4 typologies. L’utilisation de méthodes de classification et de connaissances d’experts conduit à considérer 32 stocks, 31 strates, 82 tactiques et 25 flottilles artisanales et chalutières. Les typologies sont articulées avec la prise en compte de paramètres relatifs à l’économie, aux stocks, flottilles et règles de décisions. L’ajustement est satisfaisant en partie. Toutefois, le modèle garde son importance en matière de prospective et d’objectifs à atteindre via la définition de variables de contrôle. Notre travail peut être considéré comme une esquisse invitant à un groupe de travail élargi aux experts des institutions halieutiques nationales voire, sous-régionales. Des propositions sont faites sur les bases de données, les licences de pêche et l’étude des tactiques et stratégies à mener suivant des pas de temps raisonnables pour tenir compte du grand dynamisme des pêcheries. Dès lors qu'il s’agit de caractériser l'impact de la pêche sur l'écosystème, ces travaux sont des éléments essentiels des recherches à faire sur la dynamique des écosystèmes exploités. English - The essential features of the Senegalese coast, fisheries history, fishermen's communities, artisanal and trawling fleet’s characteristics and their way of accessing to the resource and interactions are described. The characteristics, evolutionary tendencies of abundance, level of exploitation, measures of fisheries management, interspecific relationship, potential evolutionary changes and sources of variation of coastal demersal stocks are specified. Tactics and strategies are reviewed, conceptualized and studied. We used the model "Dynamique Conjointe Exploitation Ressource" which lies on 32 stocks, 31 strata, 82 tactics, 25 fleets and several other parameters dealing with stocks, fleets, economy and making decision rules. The adjustment is partially satisfactory but the model is of great interest for prospective studies and objectives to reach once defined variables of control. Our work is an outline calling for an enlarged working group implying national or sub regional fisheries institutional experts. Tactics and strategies studies, re-actualized in artisanal fisheries, are performed for the first time in industrial fisheries. The typological approach is simple, pertinent, efficacy and fast. Propositions are made relatively to databases, fishing licenses and tactics and strategies studies that should be implemented according to a reasonable time steps in order to take into account the big dynamism of the Senegalese fisheries. As it is intended to characterize fisheries impact on ecosystem, these works are one of essential research elements on the dynamic of exploited ecosystems.
    Description: Published
    Description: pêcherie; démersale côtière; modélisation; stocks; écosystème; communauté de pêcheurs; eaux continentales; eaux marines; saison hydrologique; pêcheur; flottille; crevettier; capture; aménagement des pêcheries; pêche chalutière; pêche artisanale; licence de pêche; permis de pêche
    Keywords: Fisheries ; Demersal fisheries ; Modelling ; Stocks ; Ecosystems ; Community fishing ; Inland waters ; Marine water ; Hydrologic cycle ; Fishermen ; Fishing fleet ; Shrimp fisheries ; Capture fisheries ; Fisheries management ; Trawling ; Artisanal fishing ; Fishing licenses
    Repository Name: AquaDocs
    Type: Theses and Dissertations , Bachelor thesis
    Format: 234
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  • 30
    Publication Date: 2021-05-19
    Description: Agriculture, Nature and Food Quality, Den Haag (Netherlands); Ministerie Van Buitenlandse Zaken, Brussel (Belgium); Wageningen International, Wageningen (Netherlands)
    Description: Projet BBI 13286 : Pêche durable des petits pélagiques en Afrique Nord Ouest Ce rapport a été préparé avec le soutien financier de la Coopération néerlandaise (DGIS) dans le cadre de son Programme de politique internationale en matière de biodiversité (BBI).
    Description: Published
    Description: pêche traditionnelle; taille; échantillonnage; écosystème; upwelling; biomasse; filet maillant dérivant; senne tournante; senne moustiquaire; senne de plage; maquereau; chinchard; sardinelle; ethmalose; reproduction; courant; stocks; réglementation; pêche par espéce; engin de pêche; pélagique; zone côtière; pirogue; pêche artisanale; pêcheur
    Keywords: Biomass ; Ecosystems ; Fisheries ; Fishermen ; Stocks ; Ocean currents ; Winds ; Size ; Fishing effort ; Pelagic fisheries ; Sexual reproduction ; Multispecies fisheries ; Fisheries ; Artisanal fishing ; Fishermen ; Fishing effort ; Canoe fisheries ; Coastal zone ; Fishery engineering ; Protected resources ; Pelagic fisheries ; Cycles ; Sexual reproduction ; Multispecies fisheries ; Stocks ; Ocean currents ; Winds ; Biomass ; Upwelling ; Ecosystems ; Maritime legislation ; Size
    Repository Name: AquaDocs
    Type: Report
    Format: 53
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  • 31
    Publication Date: 2021-05-19
    Description: Published
    Description: conservation
    Description: produits
    Description: pêche
    Keywords: Conservation ; Fisheries ; Fish products
    Repository Name: AquaDocs
    Type: Journal Contribution , Non-Refereed , Article
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  • 32
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    Nigerian Institute for Oceanography and Marine Research, | Lagos, Nigeria,
    Publication Date: 2021-01-30
    Description: Published
    Description: Fisheries newsletter
    Keywords: Fisheries ; Fisheries literature
    Repository Name: AquaDocs
    Type: Report , Non-Refereed
    Format: 8pp.
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  • 33
    Publication Date: 2021-01-30
    Description: En Afrique de l'Ouest, la zone littorale et ses ressources représentent une composante essentielle pour le développement. Près de 60% de la population est concentrée à moins de 20 km des côtes . La part des ressources halieutiques dans l'alimentation des populations est très importante et croissante. Au Sénégal par exemple, elles contribuent jusqu'à 70% des apports en protéines. A cela s'ajoute le poids socio-économique très important de la pêche en général et de la pêche artisanale en particulier devenue l'un des secteurs les plus stratégiques pour l'économie nationale en Mauritanie notamment. Le Cadre Stratégique de Lutte contre la Pauvreté du Gouvernement Mauritanien considère que : "compte tenu des possibilités qu'elle offre en terme de création d'emplois et de sécurité alimentaire notamment pour les populations pauvres, mais également de génération de recettes en devises, la pêche artisanale revêt une grande priorité, un plan décennal de développement lui sera consacré ".
    Description: Published
    Description: pêche artisanale; littoral; carpe; ethmalose; donnée; mulet; pélagique; pourtague; stock halieutique; pêche; communauté de pêcheurs; effort de pêche; PNBA; technique de pêche; senne tournante; sardinelle; gonade; filet de pêche; courbine; migration d'espèces; campagne de pêche; écosystème; dégradation d'habitats de poissons; enjeux socioéconomiques; commercialisation; conservation
    Keywords: Fisheries ; Fishermen ; Stocks ; Fish fillets ; Ecosystems ; Fishing effort ; Pelagic fisheries ; Artisanal fishing ; Fisheries ; Fishermen ; Stocks ; Capture fishery economics ; Fish eggs ; Fish fillets ; Fishing effort ; Fishery technology ; Mullet fisheries ; Pelagic fisheries ; Ecosystems
    Repository Name: AquaDocs
    Type: Report
    Format: 6
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  • 34
    Publication Date: 2022-05-25
    Description: Author Posting. © The Author(s), 2012. This is the author's version of the work. It is posted here by permission of Taylor & Francis for personal use, not for redistribution. The definitive version was published in Aquaculture Economics & Management 16 (2012): 167-181, doi:10.1080/13657305.2012.678551.
    Description: This study presents a framework for analyzing the interactions between aquaculture and capture fisheries in the context of ecosystem-based management. We extend a model of the economic and ecological systems in coastal New England by incorporating an aquaculture sector in a computable general equilibrium (CGE) model and by examining the forage fish and aquaculture link in a marine food web. We show that aquaculture and commercial fisheries interact in a complex way throughout the economic and ecological systems.
    Description: This work was supported by the NOAA Saltonstall-Kennedy Grant Program (Award No. NA09NMF4270097), the MIT Sea Grant College Program (NOAA Award No. NA10OAR4170086, Subaward No. 5710002974), and the Johnson Endowment of the WHOI Marine Policy Center.
    Description: 2013-06-08
    Keywords: Aquaculture ; Fisheries ; Ecosystem-based management ; CGE model ; Food web model ; Forage fish
    Repository Name: Woods Hole Open Access Server
    Type: Preprint
    Format: application/pdf
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  • 35
    Publication Date: 2022-05-25
    Description: Author Posting. © Ecological Society of America, 2013. This article is posted here by permission of Ecological Society of America for personal use, not for redistribution. The definitive version was published in Ecological Applications 23 (2013): 959–971, doi:10.1890/12-0447.1.
    Description: The biological benefits of marine reserves have garnered favor in the conservation community, but “no-take” reserve implementation is complicated by the economic interests of fishery stakeholders. There are now a number of studies examining the conditions under which marine reserves can provide both economic and ecological benefits. A potentially important reality of fishing that these studies overlook is that fishing can damage the habitat of the target stock. Here, we construct an equilibrium bioeconomic model that incorporates this habitat damage and show that the designation of marine reserves, coupled with the implementation of a tax on fishing effort, becomes both biologically and economically favorable as habitat sensitivity increases. We also study the effects of varied degrees of spatial control on fisheries management. Together, our results provide further evidence for the potential monetary and biological value of spatial management, and the possibility of a mutually beneficial resolution to the fisherman–conservationist marine reserve designation dilemma.
    Description: M. G. Neubert acknowledges the support of the National Science Foundation (DMS-0532378, OCE-1031256) and a Thomas B. Wheeler Award for Ocean Science and Society. H. V. Moeller acknowledges support from a National Science Foundation Graduate Research Fellowship. This research is based in part on work supported by Award No. USA 00002 made by King Abdullah University of Science and Technology (KAUST).
    Keywords: Bioeconomics ; Destructive fishing practices ; Fisheries ; Habitat damage ; Marine protected areas ; Marine reserves ; Optimal control ; Optimal harvesting ; Spatial management
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 36
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    Ministerio de Medio Ambiente y Medio Rural y Marino | Madrid (Espagne)
    Publication Date: 2021-05-19
    Description: Description du secteur de la pêche Avec la Mauritanie, le Sénégal est de loin le plus grand producteur de produits de pêche de la sous région. Avec 718 km de cote et un territoire maritime de 198km2, 15 745 km2 de superficie fluviale, 2 estuaires, des mangroves et un lac de 350km2, le Sénégal possède tous les atouts des plus grands producteurs de pêche. Le potentiel annuel de captures s’élève à 500 000 tonnes. Le secteur a subi une croissance spectaculaire ces trente dernières années : les débarquements sont passés 50 000 tonnes en 1965 à plus de 450 000 en 1997. Le secteur se compose principalement de deux sous-secteurs : la pêche industrielle et la pêche traditionnelle ou artisanale. Cette dernière, vielle de plusieurs siècles a su s’adapter et se moderniser au cours des dernières décennies. La flotte de pêche artisanale est dynamique et diversifiée ; selon les estimations, en 2005 il y avait plus de 13 000 pirogues. La pêche artisanale se concentre dans sept régions maritimes et fluviales du pays: Dakar, Thiès, Saint Louis, Fatick, Zinguinchor, Louga et Kaolack. Le port de Kayar dans la région de Thiès correspond à la principale zone de débarquement de la pêche artisanale avec environ 70% des débarquements. Dans le secteur industriel, les pêcheurs travaillent à bord d’une flottille de petits sardiniers, de 143 chalutiers destinés à la pêche d’espèces demersales, de 3 sardiniers et de 42 thoniers. Alors que le Sénégal domine largement le sous-secteur demersale avec 70% des chalutiers opérants, le pays ne possède que 6 thoniers contre 38 étrangers, dont une partie seulement des captures est débarquée au Sénégal. La pêche industrielle est concentrée autour de la capitale dans le Port autonome de Dakar et des ports secondaires de Saint Louis, Kaolack et Ziguinchor. Aujourd’hui, le secteur de la pêche sénégalaise est largement dominé par la pêche artisanale, qui constituait 90% des cargaisons totales des produits de la mer en 2006 avec 350 000 tonnes. Plus de 60% des produits de la pêche artisanale sont destinés à l’exportation et la transformation. En 2006, le secteur dans son ensemble représentait 9% du PIB du secteur primaire, 1.5% du PIB total, et 1/3 des devises étrangères (250 millions de dollars par an). Plus importante que le poids économique du secteur, est son poids social : la pêche génère indirectement 600 000 emplois, dont 67% au sein du secteur artisanal. En outre, les produits de la pêche comblent les besoins en protéines animales de la population sénégalaise à hauteur de 75%1. La pêche a connu une expansion spectaculaire au cours des dernières décennies grâce à l’impulsion de politiques publiques de développement basées sur une logique sectorielle productiviste. Une flotte nationale artisanale et industrielle a été progressivement mise en place ainsi que de fortes capacités de transformation industrielle. Cet engagement de l’Etat a ensuite connu un net ralentissement du fait, entre autre, des politiques d’ajustement structurel. Le renchérissement des coûts de production subséquents à la dévaluation du franc CFA en 1994 a lourdement affecté les pêcheurs. Parallèlement, avec la forte demande en produits halieutiques et en l’absence de politiques adéquates et cohérentes de gestion durable des ressources exploitables, une situation de surexploitation des ressources halieutiques s’est installée. En conséquence de la raréfaction des ressources halieutiques, la pêche sénégalaise traverse une crise sans précédent, dont les effets commencent à se faire sentir à tous les niveaux : appauvrissement des communautés de pêcheurs, menace de l’approvisionnement en poisson des populations, baisse des captures à haute valeur ajoutée, baisse des exportations, baisse de la rentabilité et des revenus des unités de pêche. Par ailleurs, de plus en plus d’établissements de transformation industrielle ferment (23 entreprises entre 1999 et 2006).
    Description: Ministerio de Medio Ambiente Y Medio Rural y Marino
    Description: Pablo Manuel Xandri Royo CTP Proyecto (INT/07/16M/SPA) Este trabajo se ha realizado en el marco del Convenio de Colaboración entre el actual Ministerio de Medio Ambiente y Medio Rural y Marino de España y la Organización Internacional del Trabajo de 28 de diciembre de 2007
    Description: Published
    Description: environnement; socio-économie; pêche; capture; débarquement; engin de pêche; femme; pêcheur; convention internationale; réglementation
    Keywords: Fisheries ; Marine environment ; Socioeconomic aspects ; Capture fisheries ; Landing statistics ; Fishing gear ; Women ; Fishermen ; Conventions ; Fishery regulations
    Repository Name: AquaDocs
    Type: Report , Non-Refereed
    Format: 208
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  • 37
    Publication Date: 2021-05-19
    Description: Programme KURUKAN FUGAN (Union Européenne/Gouvernement du Sénégal/EndaGraf/GRET)
    Description: Published
    Description: politique de pêche; environnement marin; socio-économie; co-gestion; aquaculture; pêche artisanale; pêche industrielle; pêcherie; ONG; AMP; ressource halieutique; organisations professionnelles
    Keywords: Marine environment ; Socioeconomic aspects ; Fishery management ; Aquaculture ; Artisanal fishing ; Fisheries ; Industrial fish ; Fishery resources ; Fishing policy ; Protected areas ; Professionals
    Repository Name: AquaDocs
    Type: Book , Non-Refereed , Article
    Format: 26
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  • 38
    Publication Date: 2021-01-30
    Description: Ministère des Affaires Etrangères (Sénégal); Ambassade du Sénégal à Rôme (Italy)
    Description: "Action 21"; FAO; application de l'accord; responsabilité de l'état du pavillon; échange d'informations; tiers à l'accord; règlement des différents; adhésion; entrée en vigueur; réserves; amendements; retraits; fonction du dépositaire.
    Keywords: Fisheries ; International agreements ; International cooperation ; Fisheries ; International agreements ; Maritime legislation ; International cooperation
    Repository Name: AquaDocs
    Type: Other
    Format: 14
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  • 39
    Publication Date: 2021-09-18
    Description: En la época colonial algunas especies de peces cubanos retienen sus nombres por los cuales eran conocidos por los aborígenes: biajaca, biajaiba, cojinúa, jiguagua, cibí. Aún hoy se designan de igual forma. En esta época aparece la primera obra científica impresa en Cuba, los primeros pueblos pescadores y los primeros científicos.
    Description: Published
    Keywords: Fisheries
    Repository Name: AquaDocs
    Type: Journal Contribution , Refereed , Article
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  • 40
    Publication Date: 2021-09-18
    Description: Published
    Description: especies nativas
    Description: pesca
    Keywords: Fisheries ; Indigenous species ; Indigenous fishing
    Repository Name: AquaDocs
    Type: Journal Contribution , Refereed , Article
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  • 41
    Publication Date: 2021-09-18
    Description: Published
    Keywords: Fisheries
    Repository Name: AquaDocs
    Type: Journal Contribution , Refereed , Article
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  • 42
    Publication Date: 2021-09-18
    Description: Recuento en forma breve de las pesquerías de estas especies durante varios siglos, en los cuales los sabios Parra y Felipe Poey ofrecen descripciones. Precios, lugares de captura y pescadores son los protagonistas.
    Description: Published
    Description: Emperador-Xiphias gladius
    Description: pez espada
    Description: castero-Makaira nigricans
    Description: aguja blanca-Tetrapturus albidus
    Keywords: Fisheries ; Fishes
    Repository Name: AquaDocs
    Type: Journal Contribution , Non-Refereed , Article
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  • 43
    Publication Date: 2021-09-18
    Description: Causas del descenso en las pesquerías de estas especies a partir de 1975. Se describen las técnicas y artes de pesca empleadas y se abunda en la complejidad de las capturas y las características de los palangres empleados para cada especie. Una comparación es establecida además con países del área. De forma muy didáctica e instructiva.
    Description: Published
    Description: castero-Makaira nigricans
    Description: Emperador-Xiphias gladius
    Description: aguja blanca-Tetrapturus albidus
    Keywords: Fisheries ; Fishes
    Repository Name: AquaDocs
    Type: Journal Contribution , Non-Refereed , Article
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  • 44
    Publication Date: 2022-05-26
    Description: Author Posting. © John Wiley & Sons, 2010. This is the author's version of the work. It is posted here by permission of John Wiley & Sons for personal use, not for redistribution. The definitive version was published in Aquatic Conservation: Marine and Freshwater Ecosystems 21 (2011): 17-27, doi:10.1002/aqc.1158
    Description: 1. Interactions between cetaceans and fishing activity in the Archipelago of the Azores were examined using information contained in grey literature and previously unpublished data collected by observer programmes and research projects from 1998 to 2006. Together with a brief description of the economics, gear, fishing effort, and past and ongoing monitoring projects, levels of cetacean bycatch and interference were reported for each major fishery. 2. Cetaceans were present in 7% (n=973) and interfered in 3% (n=452) of the fishing events monitored by observers aboard tuna-fishing vessels. Interference resulted in a significantly higher proportion of events with zero catches but it was also associated with higher tuna catches. 3. There was a decreasing trend in the proportion of tuna-fishing events with cetacean presence or interference throughout this study, as well as a reduction in the estimates of dolphins captured annually by the whole fleet. 4. Observers reported cetacean depredation in 16% of the sets for demersal species and in 2% of the sets for swordfish. Cetacean presence and depredation were associated with higher overall catches and higher catches per unit effort in demersal fisheries. Bottlenose dolphins (Tursiops truncatus) were responsible for most depredation events in demersal fisheries, whereas in the swordfish fishery, depredation was associated with the presence of killer whales (Orcinus orca). There were no reports of cetacean bycatch in these fisheries. There were also no reports of cetaceans interacting in the experimental deep-sea fisheries that were examined. 5. Available data suggests that levels of interaction between cetaceans and Azorean fisheries are generally low and that the economic impact of cetacean interference is probably small. However, for several traditional fisheries there are no accurate data to determine levels of cetacean interaction. We recommend that existing observer programmes be expanded to increase observer coverage of the demersal and swordfish fisheries and allow monitoring of other existing and emerging fisheries.
    Description: M.A.S. was supported by an FCT postdoctoral (SFRH/BPD/29841/2006) grant, and R.P. was supported by an FCT doctoral grant (SFRH/BD/32520/2006).
    Keywords: Cetacean–fisheries interactions ; Depredation ; Bycatch ; Fisheries ; Atlantic Ocean ; Azores
    Repository Name: Woods Hole Open Access Server
    Type: Preprint
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  • 45
    Publication Date: 2022-05-26
    Description: Author Posting. © Inter-Research, 2006. This article is posted here by permission of Inter-Research for personal use, not for redistribution. The definitive version was published in Marine Ecology Progress Series 310 (2006): 263-270, doi:10.3354/meps310263.
    Description: The longfin squid Loligo pealeii is distributed widely in the NW Atlantic and is the target of a major fishery. A previous electrophoretic study of L. pealeii was unable to prove genetic differentiation, and the fishery has been managed as a single unit stock. We tested for population structure using 5 microsatellite loci. In early summer (June), when the squids had migrated inshore to spawn, we distinguished 4 genetically distinct stocks between Delaware and Cape Cod (ca. 490 km); a 5th genetic stock occurred in Nova Scotia and a 6th in the northern Gulf of Mexico. One of the summer inshore stocks did not show genetic differentiation from 2 of the winter offshore populations. We suggest that squids from summer locations overwinter in offshore canyons and that winter offshore fishing may affect multiple stocks of the inshore fishery. In spring, squids may segregate by genetic stock as they undertake their inshore migration, indicating an underlying mechanism of subpopulation recognition.
    Description: We acknowledge funding from WHOI Sea Grant NA16RG2273, the Massachusetts Environmental Trust (#98-04), and the Sholley Foundation.
    Keywords: Fisheries ; Spawning migration ; Microsatellites ; Population structure ; Population recognition ; Null alleles
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 46
    Publication Date: 2022-05-26
    Description: Author Posting. © Foundation for Environmental Conservation, 2009. This article is posted here by permission of Cambridge University Press for personal use, not for redistribution. The definitive version was published in Environmental Conservation 36 (2009): 268-276, doi:10.1017/S0376892910000032.
    Description: No-take marine reserves are widely recognized as an effective conservation tool for protecting marine resources. Despite considerable empirical evidence that abundance and biomass of fished species increase within marine reserve boundaries, the potential for reserves to provide fisheries and conservation benefits to adjacent waters remains heavily debated. This paper uses statistical and population models to evaluate published empirical data on adult spillover from marine reserves and shows that spillover is a common phenomenon for species that respond positively to reserve protection, but at relatively small scales, detectable on average up to 800 m from reserve boundaries. At these small scales, local fisheries around reserves were likely unsustainable in 12 of 14 cases without the reserve, and spillover partially or fully offsets losses in catch due to reserve closure in the other two cases. For reserves to play a role in sustaining and replenishing larger-scale fished stocks, networks of reserves may be necessary, but as few exist this is difficult to evaluate. The results suggest reserves can simultaneously meet conservation objectives and benefit local fisheries adjacent to their boundaries.
    Description: Support was provided by a grant from the David and Lucille Packard Foundation to NCEAS for ecosystem-based management ofmarine systems, the Partnership for Interdisciplinary Studies of Coastal Oceans (PISCO) funded by the David and Lucile Packard Foundation and the Gordon and Betty Moore Foundation (contribution number 348), the Sustainable Fisheries Group supported by the Paul G. Allen Family Foundation and the Bahamas Biocomplexity Project (US NSF Biocomplexity grantOCE-0119976) andUS EPA Science to Achieve Results (R832223).
    Keywords: Adult fish movement ; Fisheries ; Global ; Marine protected areas ; No-take reserves ; Spillover effect ; Synthesis
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 47
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    Nature Publishing Group (NPG)
    Publication Date: 2010-03-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Check Hayden, Erika -- England -- Nature. 2010 Mar 18;464(7287):332-3. doi: 10.1038/464332b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20237530" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bias (Epidemiology) ; Biomedical Research/*methods ; Clinical Trials as Topic/methods ; Drug Evaluation/*methods ; Female ; Humans ; Male ; Patient Selection ; Prejudice ; *Sex Characteristics ; Sex Distribution
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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    Publication Date: 2010-04-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Check Hayden, Erika -- England -- Nature. 2010 Apr 1;464(7289):664-7. doi: 10.1038/464664a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20360709" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Data Mining ; Gene Expression Regulation ; Genes/genetics ; Genome, Human/*genetics ; Genomics/history/trends ; History, 20th Century ; History, 21st Century ; Human Genome Project/history ; Humans ; *Models, Biological ; Molecular Biology/*history ; Neoplasms/genetics/therapy ; RNA, Untranslated/genetics/metabolism ; Sea Urchins/embryology/genetics ; Systems Biology/*trends ; Tumor Suppressor Protein p53/chemistry/genetics/metabolism ; *Uncertainty
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
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    Nature Publishing Group (NPG)
    Publication Date: 2010-09-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gilbert, Natasha -- England -- Nature. 2010 Sep 16;467(7313):264-5. doi: 10.1038/467264a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20844511" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biodiversity ; Child ; Conservation of Natural Resources/*statistics & numerical data/trends ; Hominidae ; Humans ; Malnutrition/epidemiology ; Poverty/prevention & control/*statistics & numerical data/trends ; Rivers/chemistry ; United Nations ; Water Supply/statistics & numerical data
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
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    Publication Date: 2010-06-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2010 Jun 24;465(7301):985-6. doi: 10.1038/465985b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20577163" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disasters/*economics ; *Ecosystem ; Federal Government ; Industry/*economics ; Insurance/economics/*trends/utilization ; Petroleum/*adverse effects ; Risk ; United States
    Print ISSN: 0028-0836
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    Publication Date: 2010-12-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pincock, Stephen -- England -- Nature. 2010 Dec 9;468(7325):744. doi: 10.1038/468744a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21150966" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture/methods ; Animals ; Australia ; *Conservation of Natural Resources/economics ; *Ecosystem ; Endangered Species ; Environmental Policy ; *Leadership ; *Rivers/chemistry ; *Water Supply/analysis/economics
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  • 52
    Publication Date: 2010-07-27
    Description: Electrical gradients are critical for many biological processes, including the normal function of excitable tissues, left-right patterning, organogenesis and wound healing. The fundamental mechanisms that regulate the establishment and maintenance of such electrical polarities are poorly understood. Here we identify a gradient of electrical coupling across the developing ventricular myocardium using high-speed optical mapping of transmembrane potentials and calcium concentrations in the zebrafish heart. We excluded a role for differences in cellular excitability, connexin localization, tissue geometry and mechanical inputs, but in contrast we were able to demonstrate that non-canonical Wnt11 signals are required for the genesis of this myocardial electrical gradient. Although the traditional planar cell polarity pathway is not involved, we obtained evidence that Wnt11 acts to set up this gradient of electrical coupling through effects on transmembrane Ca(2+) conductance mediated by the L-type calcium channel. These data reveal a previously unrecognized role for Wnt/Ca(2+) signalling in establishing an electrical gradient in the plane of the developing cardiac epithelium through modulation of ion-channel function. The regulation of cellular coupling through such mechanisms may be a general property of non-canonical Wnt signals.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921013/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921013/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Panakova, Daniela -- Werdich, Andreas A -- Macrae, Calum A -- K08 HL068711/HL/NHLBI NIH HHS/ -- R21 GM075946/GM/NIGMS NIH HHS/ -- R21 GM075946-01/GM/NIGMS NIH HHS/ -- R21 GM075946-02/GM/NIGMS NIH HHS/ -- R21 GM075946-03/GM/NIGMS NIH HHS/ -- R21 GM075946-04/GM/NIGMS NIH HHS/ -- R21 HL098938/HL/NHLBI NIH HHS/ -- R21 HL098938-01/HL/NHLBI NIH HHS/ -- England -- Nature. 2010 Aug 12;466(7308):874-8. doi: 10.1038/nature09249. Epub 2010 Jul 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Brigham and Women's Hospital/Harvard Medical School, Cardiovascular Division, 75 Francis Street, Thorn 11, Boston, Massachusetts 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20657579" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/metabolism ; Calcium Channels, L-Type/*metabolism ; Calcium Signaling ; *Electric Conductivity ; Heart/embryology ; Ion Channel Gating/*physiology ; Myocardium/cytology/*metabolism ; Myocytes, Cardiac/metabolism ; *Signal Transduction ; Wnt Proteins/deficiency/genetics/*metabolism ; Zebrafish/*embryology/metabolism ; Zebrafish Proteins/deficiency/genetics/*metabolism
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  • 53
    Publication Date: 2010-01-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Janvier, Philippe -- Clement, Gael -- England -- Nature. 2010 Jan 7;463(7277):40-1. doi: 10.1038/463040a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20054387" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Chordata/anatomy & histology/classification/*physiology ; Extremities/anatomy & histology/physiology ; Fishes/anatomy & histology/physiology ; *Fossils ; Gait/physiology ; History, Ancient ; Models, Biological ; Phylogeny ; Poland
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    Publication Date: 2010-01-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schiermeier, Quirin -- England -- Nature. 2010 Jan 21;463(7279):284-7. doi: 10.1038/463284a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20090725" target="_blank"〉PubMed〈/a〉
    Keywords: Aerosols/analysis ; Animals ; Atmosphere/chemistry ; *Ecology/methods/standards ; Electronic Mail ; Geography ; *Global Warming ; Great Britain ; Human Activities ; Models, Theoretical ; Rain ; Snow ; Trees/anatomy & histology/growth & development ; *Uncertainty
    Print ISSN: 0028-0836
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    Publication Date: 2010-07-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Trivedi, Bijal -- England -- Nature. 2010 Jul 15;466(7304):S5. doi: 10.1038/nature09236.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20631704" target="_blank"〉PubMed〈/a〉
    Keywords: AIDS Vaccines/immunology ; Animals ; Chronic Disease ; Disease Models, Animal ; Disease Progression ; Female ; Genome, Viral/genetics ; HIV Infections/*immunology/physiopathology/virology ; HIV-1/genetics/growth & development/immunology ; Host-Pathogen Interactions/immunology ; Immunity, Innate/immunology ; Inflammation/immunology/pathology ; Interleukin-17/immunology ; Macaca/immunology/virology ; Male ; Physiology, Comparative/methods ; Primates/*immunology/metabolism/*virology ; Receptors, HIV/metabolism ; Simian Acquired Immunodeficiency Syndrome/*immunology/metabolism/virology ; Simian Immunodeficiency Virus/classification/genetics/pathogenicity/*physiology ; T-Lymphocytes, Helper-Inducer/immunology/pathology ; Viral Load
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    Publication Date: 2010-06-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zucker, Irving -- Beery, Annaliese K -- England -- Nature. 2010 Jun 10;465(7299):690. doi: 10.1038/465690a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departmentsof Psychology, Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, USA. irvzuck@berkeley.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20535186" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bias (Epidemiology) ; Biomedical Research/ethics/*methods/trends ; *Disease Models, Animal ; Female ; Humans ; Male ; Prevalence ; *Sex Characteristics ; Sex Distribution ; Sex Factors
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  • 57
    Publication Date: 2010-04-13
    Description: Interleukin (IL)-17-producing helper T (T(H)17) cells are a distinct T-cell subset characterized by its pathological role in autoimmune diseases. IL-6 and transforming growth factor-beta (TGF-beta) induce T(H)17 development, in which the orphan nuclear receptors, RORgammat and RORalpha, have an indispensable role. However, in the absence of IL-6 and TGF-beta, the ectopic expression of RORgammat or RORalpha leads to only a modest IL-17 production. Here we identify a nuclear IkappaB family member, IkappaBzeta (encoded by the Nfkbiz gene), as a transcription factor required for T(H)17 development in mice. The ectopic expression of IkappaBzeta in naive CD4(+) T cells together with RORgammat or RORalpha potently induces T(H)17 development, even in the absence of IL-6 and TGF-beta. Notably, Nfkbiz(-/-) mice have a defect in T(H)17 development and a resistance to experimental autoimmune encephalomyelitis (EAE). The T-cell-intrinsic function of IkappaBzeta was clearly demonstrated by the resistance to EAE of the Rag2(-/-) mice into which Nfkbiz(-/-) CD4(+) T cells were transferred. In cooperation with RORgammat and RORalpha, IkappaBzeta enhances Il17a expression by binding directly to the regulatory region of the Il17a gene. This study provides evidence for the transcriptional mechanisms underlying T(H)17 development and points to a molecular basis for a novel therapeutic strategy against autoimmune disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Okamoto, Kazuo -- Iwai, Yoshiko -- Oh-Hora, Masatsugu -- Yamamoto, Masahiro -- Morio, Tomohiro -- Aoki, Kazuhiro -- Ohya, Keiichi -- Jetten, Anton M -- Akira, Shizuo -- Muta, Tatsushi -- Takayanagi, Hiroshi -- Z01-ES-101586/ES/NIEHS NIH HHS/ -- Intramural NIH HHS/ -- England -- Nature. 2010 Apr 29;464(7293):1381-5. doi: 10.1038/nature08922. Epub 2010 Apr 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20383124" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Proteins, Signal Transducing ; Animals ; Coculture Techniques ; Dendritic Cells/cytology/immunology ; Encephalomyelitis, Autoimmune, Experimental/metabolism ; *Gene Expression Regulation ; Interleukin-17/biosynthesis/genetics/*metabolism ; Mice ; NF-kappa B p50 Subunit/metabolism ; Nuclear Proteins/deficiency/genetics/*metabolism ; Nuclear Receptor Subfamily 1, Group F, Member 1/genetics/*metabolism ; Nuclear Receptor Subfamily 1, Group F, Member 3/genetics/*metabolism ; Promoter Regions, Genetic/genetics ; T-Lymphocytes, Helper-Inducer/*cytology/*metabolism ; Transcription, Genetic
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  • 58
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    Nature Publishing Group (NPG)
    Publication Date: 2010-09-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zwaka, Thomas P -- England -- Nature. 2010 Sep 16;467(7313):280-1. doi: 10.1038/467280a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20844526" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation/*genetics ; Cell Lineage/*genetics ; Cellular Reprogramming/genetics ; *DNA Methylation/genetics ; Embryonic Stem Cells/cytology/metabolism ; *Epigenesis, Genetic ; Humans ; Induced Pluripotent Stem Cells/*cytology/*metabolism ; Nuclear Transfer Techniques ; Organ Specificity/genetics
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  • 59
    Publication Date: 2010-08-13
    Description: Anxious temperament (AT) in human and non-human primates is a trait-like phenotype evident early in life that is characterized by increased behavioural and physiological reactivity to mildly threatening stimuli. Studies in children demonstrate that AT is an important risk factor for the later development of anxiety disorders, depression and comorbid substance abuse. Despite its importance as an early predictor of psychopathology, little is known about the factors that predispose vulnerable children to develop AT and the brain systems that underlie its expression. To characterize the neural circuitry associated with AT and the extent to which the function of this circuit is heritable, we studied a large sample of rhesus monkeys phenotyped for AT. Using 238 young monkeys from a multigenerational single-family pedigree, we simultaneously assessed brain metabolic activity and AT while monkeys were exposed to the relevant ethological condition that elicits the phenotype. High-resolution (18)F-labelled deoxyglucose positron-emission tomography (FDG-PET) was selected as the imaging modality because it provides semi-quantitative indices of absolute glucose metabolic rate, allows for simultaneous measurement of behaviour and brain activity, and has a time course suited for assessing temperament-associated sustained brain responses. Here we demonstrate that the central nucleus region of the amygdala and the anterior hippocampus are key components of the neural circuit predictive of AT. We also show significant heritability of the AT phenotype by using quantitative genetic analysis. Additionally, using voxelwise analyses, we reveal significant heritability of metabolic activity in AT-associated hippocampal regions. However, activity in the amygdala region predictive of AT is not significantly heritable. Furthermore, the heritabilities of the hippocampal and amygdala regions significantly differ from each other. Even though these structures are closely linked, the results suggest differential influences of genes and environment on how these brain regions mediate AT and the ongoing risk of developing anxiety and depression.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998538/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998538/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Oler, Jonathan A -- Fox, Andrew S -- Shelton, Steven E -- Rogers, Jeffrey -- Dyer, Thomas D -- Davidson, Richard J -- Shelledy, Wendy -- Oakes, Terrence R -- Blangero, John -- Kalin, Ned H -- MH018931/MH/NIMH NIH HHS/ -- MH046729/MH/NIMH NIH HHS/ -- MH059490/MH/NIMH NIH HHS/ -- MH081884/MH/NIMH NIH HHS/ -- MH084051/MH/NIMH NIH HHS/ -- P50 MH084051/MH/NIMH NIH HHS/ -- P50 MH084051-030001/MH/NIMH NIH HHS/ -- R01 MH046729/MH/NIMH NIH HHS/ -- R01 MH046729-17/MH/NIMH NIH HHS/ -- R01 MH081884/MH/NIMH NIH HHS/ -- R01 MH081884-04/MH/NIMH NIH HHS/ -- R37 MH059490/MH/NIMH NIH HHS/ -- R37 MH059490-13/MH/NIMH NIH HHS/ -- England -- Nature. 2010 Aug 12;466(7308):864-8. doi: 10.1038/nature09282.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin 53719, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20703306" target="_blank"〉PubMed〈/a〉
    Keywords: Amygdala/*metabolism ; Animals ; Anxiety/*genetics/*physiopathology ; Depression/genetics ; Female ; Freezing Reaction, Cataleptic ; Genetic Predisposition to Disease/*genetics ; Glucose/metabolism ; *Heredity ; Hippocampus/*metabolism ; Macaca mulatta/genetics/physiology ; Male ; Models, Animal ; Neural Pathways/physiology ; Pedigree ; Phenotype ; Positron-Emission Tomography ; Stress, Psychological ; Temperament/*physiology ; Temporal Lobe/metabolism ; Vocalization, Animal
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  • 60
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    Nature Publishing Group (NPG)
    Publication Date: 2010-11-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2010 Nov 18;468(7322):346. doi: 10.1038/468346a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21085130" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Emigration and Immigration/*legislation & jurisprudence/*statistics & numerical ; data ; Employment/statistics & numerical data ; Great Britain ; Internationality ; Research Personnel/*legislation & jurisprudence/standards/*statistics & numerical ; data ; Science/*manpower/standards
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  • 61
    Publication Date: 2010-05-04
    Description: Polycomb group (PcG) proteins are transcriptional repressors that control processes ranging from the maintenance of cell fate decisions and stem cell pluripotency in animals to the control of flowering time in plants. In Drosophila, genetic studies identified more than 15 different PcG proteins that are required to repress homeotic (HOX) and other developmental regulator genes in cells where they must stay inactive. Biochemical analyses established that these PcG proteins exist in distinct multiprotein complexes that bind to and modify chromatin of target genes. Among those, Polycomb repressive complex 1 (PRC1) and the related dRing-associated factors (dRAF) complex contain an E3 ligase activity for monoubiquitination of histone H2A (refs 1-4). Here we show that the uncharacterized Drosophila PcG gene calypso encodes the ubiquitin carboxy-terminal hydrolase BAP1. Biochemically purified Calypso exists in a complex with the PcG protein ASX, and this complex, named Polycomb repressive deubiquitinase (PR-DUB), is bound at PcG target genes in Drosophila. Reconstituted recombinant Drosophila and human PR-DUB complexes remove monoubiquitin from H2A but not from H2B in nucleosomes. Drosophila mutants lacking PR-DUB show a strong increase in the levels of monoubiquitinated H2A. A mutation that disrupts the catalytic activity of Calypso, or absence of the ASX subunit abolishes H2A deubiquitination in vitro and HOX gene repression in vivo. Polycomb gene silencing may thus entail a dynamic balance between H2A ubiquitination by PRC1 and dRAF, and H2A deubiquitination by PR-DUB.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182123/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182123/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Scheuermann, Johanna C -- de Ayala Alonso, Andres Gaytan -- Oktaba, Katarzyna -- Ly-Hartig, Nga -- McGinty, Robert K -- Fraterman, Sven -- Wilm, Matthias -- Muir, Tom W -- Muller, Jurg -- R01 GM086868/GM/NIGMS NIH HHS/ -- R01 GM086868-13/GM/NIGMS NIH HHS/ -- RC2 CA148354/CA/NCI NIH HHS/ -- RC2 CA148354-02/CA/NCI NIH HHS/ -- RC2CA148354/CA/NCI NIH HHS/ -- England -- Nature. 2010 May 13;465(7295):243-7. doi: 10.1038/nature08966. Epub 2010 May 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20436459" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; Biocatalysis ; Drosophila Proteins/genetics/*metabolism ; Drosophila melanogaster/embryology/*enzymology/genetics/metabolism ; Gene Silencing ; Genes, Homeobox/genetics ; Genes, Insect/genetics ; Genetic Complementation Test ; Histones/*metabolism ; Humans ; Multiprotein Complexes/chemistry/isolation & purification/*metabolism ; Nucleosomes/chemistry/metabolism ; Polycomb Repressive Complex 1 ; Repressor Proteins/genetics/isolation & purification/*metabolism ; Ubiquitin/metabolism ; Ubiquitin Thiolesterase/chemistry/genetics/*metabolism ; Ubiquitination/*physiology
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  • 62
    Publication Date: 2010-07-20
    Description: DNA methylation is one of the best-characterized epigenetic modifications. Although the enzymes that catalyse DNA methylation have been characterized, enzymes responsible for demethylation have been elusive. A recent study indicates that the human TET1 protein could catalyse the conversion of 5-methylcytosine (5mC) of DNA to 5-hydroxymethylcytosine (5hmC), raising the possibility that DNA demethylation may be a Tet1-mediated process. Here we extend this study by demonstrating that all three mouse Tet proteins (Tet1, Tet2 and Tet3) can also catalyse a similar reaction. Tet1 has an important role in mouse embryonic stem (ES) cell maintenance through maintaining the expression of Nanog in ES cells. Downregulation of Nanog via Tet1 knockdown correlates with methylation of the Nanog promoter, supporting a role for Tet1 in regulating DNA methylation status. Furthermore, knockdown of Tet1 in pre-implantation embryos results in a bias towards trophectoderm differentiation. Thus, our studies not only uncover the enzymatic activity of the Tet proteins, but also demonstrate a role for Tet1 in ES cell maintenance and inner cell mass cell specification.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491567/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491567/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ito, Shinsuke -- D'Alessio, Ana C -- Taranova, Olena V -- Hong, Kwonho -- Sowers, Lawrence C -- Zhang, Yi -- CA084487/CA/NCI NIH HHS/ -- GM68804/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2010 Aug 26;466(7310):1129-33. doi: 10.1038/nature09303.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20639862" target="_blank"〉PubMed〈/a〉
    Keywords: 5-Methylcytosine/*metabolism ; Alkaline Phosphatase/metabolism ; Animals ; Blastocyst Inner Cell Mass/*metabolism ; Cell Proliferation ; Cytosine/*analogs & derivatives/metabolism ; DNA-Binding Proteins/genetics/*metabolism ; Embryonic Stem Cells/*cytology ; Gene Expression Regulation, Developmental ; Gene Knockdown Techniques ; Homeodomain Proteins/metabolism ; Mice ; Proto-Oncogene Proteins/genetics/*metabolism
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  • 63
    Publication Date: 2010-01-22
    Description: Among the extraordinary adaptations driven by sperm competition is the cooperative behaviour of spermatozoa. By forming cooperative groups, sperm can increase their swimming velocity and thereby gain an advantage in intermale sperm competition. Accordingly, selection should favour cooperation of the most closely related sperm to maximize fitness. Here we show that sperm of deer mice (genus Peromyscus) form motile aggregations, then we use this system to test predictions of sperm cooperation. We find that sperm aggregate more often with conspecific than heterospecific sperm, suggesting that individual sperm can discriminate on the basis of genetic relatedness. Next, we provide evidence that the cooperative behaviour of closely related sperm is driven by sperm competition. In a monogamous species lacking sperm competition, Peromyscus polionotus, sperm indiscriminately group with unrelated conspecific sperm. In contrast, in the highly promiscuous deer mouse, Peromyscus maniculatus, sperm are significantly more likely to aggregate with those obtained from the same male than with sperm from an unrelated conspecific donor. Even when we test sperm from sibling males, we continue to see preferential aggregations of related sperm in P. maniculatus. These results suggest that sperm from promiscuous deer mice discriminate among relatives and thereby cooperate with the most closely related sperm, an adaptation likely to have been driven by sperm competition.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824558/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824558/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fisher, Heidi S -- Hoekstra, Hopi E -- F32 GM084719/GM/NIGMS NIH HHS/ -- F32 GM084719-02/GM/NIGMS NIH HHS/ -- England -- Nature. 2010 Feb 11;463(7282):801-3. doi: 10.1038/nature08736. Epub 2010 Jan 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Organismic and Evolutionary Biology, Museum of Comparative Zoology, Cambridge, Massachusetts 02138, USA. hfisher@oeb.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20090679" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Aggregation ; Competitive Behavior/*physiology ; *Cooperative Behavior ; Copulation/physiology ; Female ; Male ; Peromyscus/*classification/*physiology ; Sexual Behavior, Animal/*physiology ; Species Specificity ; Sperm Motility/physiology ; Spermatozoa/*physiology
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  • 64
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    Nature Publishing Group (NPG)
    Publication Date: 2010-04-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lincoln, Tim -- England -- Nature. 2010 Apr 15;464(7291):990. doi: 10.1038/464990a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20393551" target="_blank"〉PubMed〈/a〉
    Keywords: Air ; Animals ; Perciformes/anatomy & histology/*physiology ; Predatory Behavior/physiology ; Retina/anatomy & histology/*physiology ; Rivers ; Vision, Ocular/*physiology
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  • 65
    Publication Date: 2010-07-20
    Description: Chronic myelogenous leukaemia (CML) can progress from a slow growing chronic phase to an aggressive blast crisis phase, but the molecular basis of this transition remains poorly understood. Here we have used mouse models of CML to show that disease progression is regulated by the Musashi-Numb signalling axis. Specifically, we find that the chronic phase is marked by high levels of Numb expression whereas the blast crisis phase has low levels of Numb expression, and that ectopic expression of Numb promotes differentiation and impairs advanced-phase disease in vivo. As a possible explanation for the decreased levels of Numb in the blast crisis phase, we show that NUP98-HOXA9, an oncogene associated with blast crisis CML, can trigger expression of the RNA-binding protein Musashi2 (Msi2), which in turn represses Numb. Notably, loss of Msi2 restores Numb expression and significantly impairs the development and propagation of blast crisis CML in vitro and in vivo. Finally we show that Msi2 expression is not only highly upregulated during human CML progression but is also an early indicator of poorer prognosis. These data show that the Musashi-Numb pathway can control the differentiation of CML cells, and raise the possibility that targeting this pathway may provide a new strategy for the therapy of aggressive leukaemias.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918284/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918284/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ito, Takahiro -- Kwon, Hyog Young -- Zimdahl, Bryan -- Congdon, Kendra L -- Blum, Jordan -- Lento, William E -- Zhao, Chen -- Lagoo, Anand -- Gerrard, Gareth -- Foroni, Letizia -- Goldman, John -- Goh, Harriet -- Kim, Soo-Hyun -- Kim, Dong-Wook -- Chuah, Charles -- Oehler, Vivian G -- Radich, Jerald P -- Jordan, Craig T -- Reya, Tannishtha -- AI067798/AI/NIAID NIH HHS/ -- CA122206/CA/NCI NIH HHS/ -- CA140371/CA/NCI NIH HHS/ -- CA18029/CA/NCI NIH HHS/ -- DK072234/DK/NIDDK NIH HHS/ -- DK63031/DK/NIDDK NIH HHS/ -- DP1 CA174422/CA/NCI NIH HHS/ -- DP1 OD006430/OD/NIH HHS/ -- DP1 OD006430-01/OD/NIH HHS/ -- DP1 OD006430-02/OD/NIH HHS/ -- DP1OD006430/OD/NIH HHS/ -- HL097767/HL/NHLBI NIH HHS/ -- P01 CA018029/CA/NCI NIH HHS/ -- R01 CA140371/CA/NCI NIH HHS/ -- R01 DK063031/DK/NIDDK NIH HHS/ -- R01 DK063031-01/DK/NIDDK NIH HHS/ -- R01 DK063031-01S1/DK/NIDDK NIH HHS/ -- R01 DK063031-02/DK/NIDDK NIH HHS/ -- R01 DK063031-03/DK/NIDDK NIH HHS/ -- R01 DK063031-04/DK/NIDDK NIH HHS/ -- R01 DK063031-05/DK/NIDDK NIH HHS/ -- R01 DK063031-06/DK/NIDDK NIH HHS/ -- R01 DK063031-07/DK/NIDDK NIH HHS/ -- R01 DK063031-07S1/DK/NIDDK NIH HHS/ -- R01 DK063031-08/DK/NIDDK NIH HHS/ -- R01 DK072234/DK/NIDDK NIH HHS/ -- R01 DK072234-01A1/DK/NIDDK NIH HHS/ -- R01 DK072234-02/DK/NIDDK NIH HHS/ -- R01 DK072234-03/DK/NIDDK NIH HHS/ -- R01 DK072234-04/DK/NIDDK NIH HHS/ -- R01 HL097767/HL/NHLBI NIH HHS/ -- R01 HL097767-01/HL/NHLBI NIH HHS/ -- R01 HL097767-02/HL/NHLBI NIH HHS/ -- T32 GM007184-33/GM/NIGMS NIH HHS/ -- U19 AI067798/AI/NIAID NIH HHS/ -- U19 AI067798-010006/AI/NIAID NIH HHS/ -- U19 AI067798-020006/AI/NIAID NIH HHS/ -- U19 AI067798-030006/AI/NIAID NIH HHS/ -- U19 AI067798-040006/AI/NIAID NIH HHS/ -- U19 AI067798-050006/AI/NIAID NIH HHS/ -- England -- Nature. 2010 Aug 5;466(7307):765-8. doi: 10.1038/nature09171. Epub 2010 Jul 18.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20639863" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blast Crisis/genetics/metabolism/pathology ; *Cell Differentiation/genetics ; Disease Progression ; Fusion Proteins, bcr-abl/genetics/metabolism ; Gene Expression Regulation, Neoplastic ; Homeodomain Proteins/genetics/metabolism ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics/*metabolism/*pathology ; Membrane Proteins/biosynthesis/genetics/metabolism ; Mice ; Mice, Inbred C57BL ; Nerve Tissue Proteins/biosynthesis/genetics/metabolism ; Nuclear Pore Complex Proteins/genetics/metabolism ; Oncogene Proteins, Fusion/genetics/metabolism ; Prognosis ; RNA-Binding Proteins/biosynthesis/genetics/*metabolism ; Receptor, Notch1/metabolism ; Signal Transduction ; Tumor Suppressor Protein p53/metabolism ; Up-Regulation
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  • 66
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    Nature Publishing Group (NPG)
    Publication Date: 2010-06-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chi, Kelly Rae -- England -- Nature. 2010 May 13;465(7295):256-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20549837" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Genome/genetics ; Genomics/economics/instrumentation/*manpower/*trends ; Humans ; Sequence Analysis, DNA/economics/instrumentation/statistics & numerical ; data/trends ; Software ; Viruses/genetics/isolation & purification
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  • 67
    Publication Date: 2010-05-21
    Description: Malaria is a devastating infection caused by protozoa of the genus Plasmodium. Drug resistance is widespread, no new chemical class of antimalarials has been introduced into clinical practice since 1996 and there is a recent rise of parasite strains with reduced sensitivity to the newest drugs. We screened nearly 2 million compounds in GlaxoSmithKline's chemical library for inhibitors of P. falciparum, of which 13,533 were confirmed to inhibit parasite growth by at least 80% at 2 microM concentration. More than 8,000 also showed potent activity against the multidrug resistant strain Dd2. Most (82%) compounds originate from internal company projects and are new to the malaria community. Analyses using historic assay data suggest several novel mechanisms of antimalarial action, such as inhibition of protein kinases and host-pathogen interaction related targets. Chemical structures and associated data are hereby made public to encourage additional drug lead identification efforts and further research into this disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gamo, Francisco-Javier -- Sanz, Laura M -- Vidal, Jaume -- de Cozar, Cristina -- Alvarez, Emilio -- Lavandera, Jose-Luis -- Vanderwall, Dana E -- Green, Darren V S -- Kumar, Vinod -- Hasan, Samiul -- Brown, James R -- Peishoff, Catherine E -- Cardon, Lon R -- Garcia-Bustos, Jose F -- England -- Nature. 2010 May 20;465(7296):305-10. doi: 10.1038/nature09107.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Tres Cantos Medicines Development Campus, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Spain.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20485427" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antimalarials/*analysis/chemistry/*pharmacology/toxicity ; Cell Line, Tumor ; *Drug Discovery ; Drug Resistance, Multiple/drug effects ; Humans ; Malaria, Falciparum/*drug therapy/parasitology ; Models, Biological ; Phylogeny ; Plasmodium falciparum/*drug effects/enzymology/genetics/growth & development ; Small Molecule Libraries/*analysis/chemistry/*pharmacology/toxicity
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  • 68
    Publication Date: 2010-05-14
    Description: The main reason why tumours are not controlled by the immune system is that, unlike pathogens, they do not express potent tumour rejection antigens (TRAs). Tumour vaccination aims at stimulating a systemic immune response targeted to, mostly weak, antigens expressed in the disseminated tumour lesions. Main challenges in developing effective vaccination protocols are the identification of potent and broadly expressed TRAs and effective adjuvants to stimulate a robust and durable immune response. Here we describe an alternative approach in which the expression of new, and thereby potent, antigens are induced in tumour cells by inhibiting nonsense-mediated messenger RNA decay (NMD). Small interfering RNA (siRNA)-mediated inhibition of NMD in tumour cells led to the expression of new antigenic determinants and their immune-mediated rejection. In subcutaneous and metastatic tumour models, tumour-targeted delivery of NMD factor-specific siRNAs conjugated to oligonucleotide aptamer ligands led to significant inhibition of tumour growth that was superior to that of vaccination with granulocyte-macrophage colony-stimulating factor (GM-CSF)-expressing irradiated tumour cells, and could be further enhanced by co-stimulation. Tumour-targeted NMD inhibition forms the basis of a simple, broadly useful, and clinically feasible approach to enhance the antigenicity of disseminated tumours leading to their immune recognition and rejection. The cell-free chemically synthesized oligonucleotide backbone of aptamer-siRNAs reduces the risk of immunogenicity and enhances the feasibility of generating reagents suitable for clinical use.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107067/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107067/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pastor, Fernando -- Kolonias, Despina -- Giangrande, Paloma H -- Gilboa, Eli -- R01 CA138503/CA/NCI NIH HHS/ -- R01 CA151857-02/CA/NCI NIH HHS/ -- England -- Nature. 2010 May 13;465(7295):227-30. doi: 10.1038/nature08999.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology & Immunology, Dodson Interdisciplinary Immunotherapy Institute, University of Miami Miller School of Medicine Miami, Florida 33134, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20463739" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Neoplasm/*genetics/*immunology ; Aptamers, Nucleotide/genetics ; Cancer Vaccines/genetics/immunology/metabolism ; Carrier Proteins/genetics ; Cell Line, Tumor ; Chickens/genetics ; Colonic Neoplasms/*genetics/*immunology/pathology ; Gene Expression Regulation, Neoplastic ; Granulocyte-Macrophage Colony-Stimulating Factor/genetics/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Nude ; Neoplasm Transplantation ; RNA Interference ; RNA Stability/*genetics ; RNA, Small Interfering/*genetics/therapeutic use ; Xenograft Model Antitumor Assays
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  • 69
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    Unknown
    Nature Publishing Group (NPG)
    Publication Date: 2010-12-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Benton, Richard -- England -- Nature. 2010 Dec 2;468(7324):638-40. doi: 10.1038/468638a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21124442" target="_blank"〉PubMed〈/a〉
    Keywords: Acetates/pharmacology ; Animals ; Drosophila Proteins/genetics/metabolism ; Drosophila melanogaster/anatomy & histology/*cytology/*drug effects/physiology ; Female ; Gene Expression Regulation ; Male ; Nerve Tissue Proteins/genetics/metabolism ; Neuroanatomical Tract-Tracing Techniques/methods ; Oleic Acids/pharmacology ; Olfactory Pathways/anatomy & histology/cytology/*drug effects ; Olfactory Perception/drug effects/physiology ; Pheromones/*pharmacology ; Sensory Receptor Cells/drug effects/physiology ; *Sex Characteristics ; Sexual Behavior, Animal/physiology ; Transcription Factors/genetics/metabolism
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  • 70
    Publication Date: 2010-12-03
    Description: The capacity to fine-tune cellular bioenergetics with the demands of stem-cell maintenance and regeneration is central to normal development and ageing, and to organismal survival during periods of acute stress. How energy metabolism and stem-cell homeostatic processes are coordinated is not well understood. Lkb1 acts as an evolutionarily conserved regulator of cellular energy metabolism in eukaryotic cells and functions as the major upstream kinase to phosphorylate AMP-activated protein kinase (AMPK) and 12 other AMPK-related kinases. Whether Lkb1 regulates stem-cell maintenance remains unknown. Here we show that Lkb1 has an essential role in haematopoietic stem cell (HSC) homeostasis. We demonstrate that ablation of Lkb1 in adult mice results in severe pancytopenia and subsequent lethality. Loss of Lkb1 leads to impaired survival and escape from quiescence of HSCs, resulting in exhaustion of the HSC pool and a marked reduction of HSC repopulating potential in vivo. Lkb1 deletion has an impact on cell proliferation in HSCs, but not on more committed compartments, pointing to context-specific functions for Lkb1 in haematopoiesis. The adverse impact of Lkb1 deletion on haematopoiesis was predominantly cell-autonomous and mTOR complex 1 (mTORC1)-independent, and involves multiple mechanisms converging on mitochondrial apoptosis and possibly downregulation of PGC-1 coactivators and their transcriptional network, which have critical roles in mitochondrial biogenesis and function. Thus, Lkb1 serves as an essential regulator of HSCs and haematopoiesis, and more generally, points to the critical importance of coupling energy metabolism and stem-cell homeostasis.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058342/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058342/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gan, Boyi -- Hu, Jian -- Jiang, Shan -- Liu, Yingchun -- Sahin, Ergun -- Zhuang, Li -- Fletcher-Sananikone, Eliot -- Colla, Simona -- Wang, Y Alan -- Chin, Lynda -- Depinho, Ronald A -- 01CA141508/CA/NCI NIH HHS/ -- R21 CA135057/CA/NCI NIH HHS/ -- R21 CA135057-01/CA/NCI NIH HHS/ -- R21CA135057/CA/NCI NIH HHS/ -- U01 CA141508/CA/NCI NIH HHS/ -- U01 CA141508-01/CA/NCI NIH HHS/ -- England -- Nature. 2010 Dec 2;468(7324):701-4. doi: 10.1038/nature09595.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21124456" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis ; Cell Cycle/*physiology ; Cell Proliferation ; Cell Survival ; *Energy Metabolism ; Female ; Gene Deletion ; Hematopoiesis ; Hematopoietic Stem Cells/*cytology/*metabolism/pathology ; *Homeostasis ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mitochondria/metabolism/pathology ; Multiprotein Complexes ; Pancytopenia/genetics ; Phenotype ; Protein-Serine-Threonine Kinases/deficiency/genetics/*metabolism ; Proteins/metabolism ; Survival Analysis ; TOR Serine-Threonine Kinases ; Transcription Factors/metabolism
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  • 71
    Publication Date: 2010-06-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schmidt, Thomas -- Carmeliet, Peter -- England -- Nature. 2010 Jun 10;465(7299):697-9. doi: 10.1038/465697a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20535192" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Vessels/*cytology/*growth & development ; Cell Fusion ; Endothelial Cells/*cytology/physiology ; Macrophages/*cytology/*physiology ; Neovascularization, Pathologic/pathology/physiopathology ; Neovascularization, Physiologic/*physiology ; Pseudopodia/physiology
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  • 72
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    Unknown
    Nature Publishing Group (NPG)
    Publication Date: 2010-09-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2010 Sep 23;467(7314):368. doi: 10.1038/467368a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20864950" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture/*methods ; Animals ; Cattle ; Disease Reservoirs/microbiology/*statistics & numerical data/*veterinary ; *Federal Government ; Great Britain/epidemiology ; *Mustelidae/microbiology ; Reproducibility of Results ; Tuberculosis Vaccines ; Tuberculosis, Bovine/epidemiology/*prevention & control/transmission ; Vaccination/veterinary
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  • 73
    Publication Date: 2010-01-19
    Description: Influenza A virus, being responsible for seasonal epidemics and reoccurring pandemics, represents a worldwide threat to public health. High mutation rates facilitate the generation of viral escape mutants, rendering vaccines and drugs directed against virus-encoded targets potentially ineffective. In contrast, targeting host cell determinants temporarily dispensable for the host but crucial for virus replication could prevent viral escape. Here we report the discovery of 287 human host cell genes influencing influenza A virus replication in a genome-wide RNA interference (RNAi) screen. Using an independent assay we confirmed 168 hits (59%) inhibiting either the endemic H1N1 (119 hits) or the current pandemic swine-origin (121 hits) influenza A virus strains, with an overlap of 60%. Notably, a subset of these common hits was also essential for replication of a highly pathogenic avian H5N1 strain. In-depth analyses of several factors provided insights into their infection stage relevance. Notably, SON DNA binding protein (SON) was found to be important for normal trafficking of influenza virions to late endosomes early in infection. We also show that a small molecule inhibitor of CDC-like kinase 1 (CLK1) reduces influenza virus replication by more than two orders of magnitude, an effect connected with impaired splicing of the viral M2 messenger RNA. Furthermore, influenza-virus-infected p27(-/-) (cyclin-dependent kinase inhibitor 1B; Cdkn1b) mice accumulated significantly lower viral titres in the lung, providing in vivo evidence for the importance of this gene. Thus, our results highlight the potency of genome-wide RNAi screening for the dissection of virus-host interactions and the identification of drug targets for a broad range of influenza viruses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Karlas, Alexander -- Machuy, Nikolaus -- Shin, Yujin -- Pleissner, Klaus-Peter -- Artarini, Anita -- Heuer, Dagmar -- Becker, Daniel -- Khalil, Hany -- Ogilvie, Lesley A -- Hess, Simone -- Maurer, Andre P -- Muller, Elke -- Wolff, Thorsten -- Rudel, Thomas -- Meyer, Thomas F -- England -- Nature. 2010 Feb 11;463(7282):818-22. doi: 10.1038/nature08760. Epub 2010 Jan 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Biology Department, Max Planck Institute for Infection Biology, Chariteplatz 1, 10117 Berlin, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20081832" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Factors/genetics/metabolism ; Cell Line ; Cells, Cultured ; Chick Embryo ; Cyclin-Dependent Kinase Inhibitor p27/deficiency/genetics/metabolism ; Epithelial Cells/virology ; Genome, Human/genetics ; *Host-Pathogen Interactions/genetics/physiology ; Humans ; Influenza A Virus, H1N1 Subtype/classification/*growth & development ; Influenza, Human/*genetics/*virology ; Lung/cytology ; Mice ; Mice, Inbred C57BL ; Protein-Serine-Threonine Kinases/genetics ; Protein-Tyrosine Kinases/genetics ; *RNA Interference ; Virus Replication/*physiology
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  • 74
    Publication Date: 2010-09-25
    Description: Plasmodium falciparum is the most prevalent and lethal of the malaria parasites infecting humans, yet the origin and evolutionary history of this important pathogen remain controversial. Here we develop a single-genome amplification strategy to identify and characterize Plasmodium spp. DNA sequences in faecal samples from wild-living apes. Among nearly 3,000 specimens collected from field sites throughout central Africa, we found Plasmodium infection in chimpanzees (Pan troglodytes) and western gorillas (Gorilla gorilla), but not in eastern gorillas (Gorilla beringei) or bonobos (Pan paniscus). Ape plasmodial infections were highly prevalent, widely distributed and almost always made up of mixed parasite species. Analysis of more than 1,100 mitochondrial, apicoplast and nuclear gene sequences from chimpanzees and gorillas revealed that 99% grouped within one of six host-specific lineages representing distinct Plasmodium species within the subgenus Laverania. One of these from western gorillas comprised parasites that were nearly identical to P. falciparum. In phylogenetic analyses of full-length mitochondrial sequences, human P. falciparum formed a monophyletic lineage within the gorilla parasite radiation. These findings indicate that P. falciparum is of gorilla origin and not of chimpanzee, bonobo or ancient human origin.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997044/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997044/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, Weimin -- Li, Yingying -- Learn, Gerald H -- Rudicell, Rebecca S -- Robertson, Joel D -- Keele, Brandon F -- Ndjango, Jean-Bosco N -- Sanz, Crickette M -- Morgan, David B -- Locatelli, Sabrina -- Gonder, Mary K -- Kranzusch, Philip J -- Walsh, Peter D -- Delaporte, Eric -- Mpoudi-Ngole, Eitel -- Georgiev, Alexander V -- Muller, Martin N -- Shaw, George M -- Peeters, Martine -- Sharp, Paul M -- Rayner, Julian C -- Hahn, Beatrice H -- P30 AI 7767/AI/NIAID NIH HHS/ -- P30 AI027767/AI/NIAID NIH HHS/ -- P30 AI027767-21A1/AI/NIAID NIH HHS/ -- R01 AI058715/AI/NIAID NIH HHS/ -- R01 AI058715-06A1/AI/NIAID NIH HHS/ -- R01 AI058715-07/AI/NIAID NIH HHS/ -- R01 AI50529/AI/NIAID NIH HHS/ -- R01 I58715/PHS HHS/ -- R03 AI074778/AI/NIAID NIH HHS/ -- R03 AI074778-02/AI/NIAID NIH HHS/ -- R37 AI050529/AI/NIAID NIH HHS/ -- R37 AI050529-07/AI/NIAID NIH HHS/ -- R37 AI050529-08/AI/NIAID NIH HHS/ -- T32 AI007245/AI/NIAID NIH HHS/ -- T32 AI007245-26/AI/NIAID NIH HHS/ -- T32 GM008111/GM/NIGMS NIH HHS/ -- T32 GM008111-13/GM/NIGMS NIH HHS/ -- U19 AI 067854/AI/NIAID NIH HHS/ -- U19 AI067854/AI/NIAID NIH HHS/ -- U19 AI067854-06/AI/NIAID NIH HHS/ -- Howard Hughes Medical Institute/ -- Wellcome Trust/United Kingdom -- England -- Nature. 2010 Sep 23;467(7314):420-5. doi: 10.1038/nature09442.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20864995" target="_blank"〉PubMed〈/a〉
    Keywords: Africa/epidemiology ; Animals ; Animals, Wild/classification/parasitology ; Ape Diseases/epidemiology/*parasitology/transmission ; DNA, Mitochondrial/analysis/genetics ; Evolution, Molecular ; Feces/parasitology ; Genes, Mitochondrial/genetics ; Genetic Variation/genetics ; Genome, Protozoan/genetics ; Gorilla gorilla/classification/*parasitology ; Humans ; Malaria, Falciparum/epidemiology/*parasitology/transmission/*veterinary ; Molecular Sequence Data ; Pan paniscus/parasitology ; Pan troglodytes/parasitology ; Phylogeny ; Plasmodium/classification/genetics/isolation & purification ; Plasmodium falciparum/genetics/*isolation & purification ; Prevalence ; Zoonoses/parasitology/transmission
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  • 75
    Publication Date: 2010-09-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cock, Matthew -- England -- Nature. 2010 Sep 23;467(7314):369. doi: 10.1038/467369a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉CABI, Delemont, Switzerland. m.cock@cabi.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20864952" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; Animals ; International Cooperation/*legislation & jurisprudence ; Manihot ; Pest Control, Biological/economics/*legislation & jurisprudence ; South America ; Theft/*legislation & jurisprudence ; United States ; Wasps
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  • 76
    Publication Date: 2010-01-26
    Description: Echolocation is an active form of orientation in which animals emit sounds and then listen to reflected echoes of those sounds to form images of their surroundings in their brains. Although echolocation is usually associated with bats, it is not characteristic of all bats. Most echolocating bats produce signals in the larynx, but within one family of mainly non-echolocating species (Pteropodidae), a few species use echolocation sounds produced by tongue clicks. Here we demonstrate, using data obtained from micro-computed tomography scans of 26 species (n = 35 fluid-preserved bats), that proximal articulation of the stylohyal bone (part of the mammalian hyoid apparatus) with the tympanic bone always distinguishes laryngeally echolocating bats from all other bats (that is, non-echolocating pteropodids and those that echolocate with tongue clicks). In laryngeally echolocating bats, the proximal end of the stylohyal bone directly articulates with the tympanic bone and is often fused with it. Previous research on the morphology of the stylohyal bone in the oldest known fossil bat (Onychonycteris finneyi) suggested that it did not echolocate, but our findings suggest that O. finneyi may have used laryngeal echolocation because its stylohyal bones may have articulated with its tympanic bones. The present findings reopen basic questions about the timing and the origin of flight and echolocation in the early evolution of bats. Our data also provide an independent anatomical character by which to distinguish laryngeally echolocating bats from other bats.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Veselka, Nina -- McErlain, David D -- Holdsworth, David W -- Eger, Judith L -- Chhem, Rethy K -- Mason, Matthew J -- Brain, Kirsty L -- Faure, Paul A -- Fenton, M Brock -- MOP-89852/Canadian Institutes of Health Research/Canada -- England -- Nature. 2010 Feb 18;463(7283):939-42. doi: 10.1038/nature08737. Epub 2010 Jan 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Robarts Research Institute.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20098413" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Bone Conduction/*physiology ; Bone and Bones/anatomy & histology/*physiology ; Chiroptera/*anatomy & histology/classification/*physiology ; Ear/anatomy & histology/physiology ; Echolocation/*physiology ; Flight, Animal/physiology ; Fossils ; Larynx/*physiology ; Orientation/physiology ; Skull/anatomy & histology/physiology ; Tongue/physiology
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  • 77
    Publication Date: 2010-02-09
    Description: Ca(2+) channels and calmodulin (CaM) are two prominent signalling hubs that synergistically affect functions as diverse as cardiac excitability, synaptic plasticity and gene transcription. It is therefore fitting that these hubs are in some sense coordinated, as the opening of Ca(V)1-2 Ca(2+) channels are regulated by a single CaM constitutively complexed with channels. The Ca(2+)-free form of CaM (apoCaM) is already pre-associated with the isoleucine-glutamine (IQ) domain on the channel carboxy terminus, and subsequent Ca(2+) binding to this 'resident' CaM drives conformational changes that then trigger regulation of channel opening. Another potential avenue for channel-CaM coordination could arise from the absence of Ca(2+) regulation in channels lacking a pre-associated CaM. Natural fluctuations in CaM concentrations might then influence the fraction of regulable channels and, thereby, the overall strength of Ca(2+) feedback. However, the prevailing view has been that the ultrastrong affinity of channels for apoCaM ensures their saturation with CaM, yielding a significant form of concentration independence between Ca(2+) channels and CaM. Here we show that significant exceptions to this autonomy exist, by combining electrophysiology (to characterize channel regulation) with optical fluorescence resonance energy transfer (FRET) sensor determination of free-apoCaM concentration in live cells. This approach translates quantitative CaM biochemistry from the traditional test-tube context into the realm of functioning holochannels within intact cells. From this perspective, we find that long splice forms of Ca(V)1.3 and Ca(V)1.4 channels include a distal carboxy tail that resembles an enzyme competitive inhibitor that retunes channel affinity for apoCaM such that natural CaM variations affect the strength of Ca(2+) feedback modulation. Given the ubiquity of these channels, the connection between ambient CaM levels and Ca(2+) entry through channels is broadly significant for Ca(2+) homeostasis. Strategies such as ours promise key advances for the in situ analysis of signalling molecules resistant to in vitro reconstitution, such as Ca(2+) channels.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553577/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553577/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, Xiaodong -- Yang, Philemon S -- Yang, Wanjun -- Yue, David T -- P30 DC005211/DC/NIDCD NIH HHS/ -- R01 DC000276/DC/NIDCD NIH HHS/ -- England -- Nature. 2010 Feb 18;463(7283):968-72. doi: 10.1038/nature08766. Epub 2010 Feb 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Calcium Signals Laboratory, Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Ross Building, Room 713, 720 Rutland Avenue, Baltimore, Maryland 21205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20139964" target="_blank"〉PubMed〈/a〉
    Keywords: Alternative Splicing ; Animals ; Apoproteins/analysis/metabolism ; Binding, Competitive/drug effects ; Calcium/analysis/metabolism/pharmacology ; Calcium Channel Blockers/*chemistry/*metabolism ; Calcium Channels/*chemistry/genetics/*metabolism ; Calmodulin/analysis/*metabolism ; Cell Line ; Cell Survival ; Electrophysiology ; *Feedback, Physiological ; Fluorescence Resonance Energy Transfer ; Humans ; Protein Structure, Tertiary ; Rats ; Recombinant Fusion Proteins/chemistry/genetics/metabolism
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  • 78
    Publication Date: 2010-02-23
    Description: Although bisexual reproduction has proven to be highly successful, parthenogenetic all-female populations occur frequently in certain taxa, including the whiptail lizards of the genus Aspidoscelis. Allozyme analysis revealed a high degree of fixed heterozygosity in these parthenogenetic species, supporting the view that they originated from hybridization events between related sexual species. It has remained unclear how the meiotic program is altered to produce diploid eggs while maintaining heterozygosity. Here we show that meiosis commences with twice the number of chromosomes in parthenogenetic versus sexual species, a mechanism that provides the basis for generating gametes with unreduced chromosome content without fundamental deviation from the classic meiotic program. Our observation of synaptonemal complexes and chiasmata demonstrate that a typical meiotic program occurs and that heterozygosity is not maintained by bypassing recombination. Instead, fluorescent in situ hybridization probes that distinguish between homologues reveal that bivalents form between sister chromosomes, the genetically identical products of the first of two premeiotic replication cycles. Sister chromosome pairing provides a mechanism for the maintenance of heterozygosity, which is critical for offsetting the reduced fitness associated with the lack of genetic diversity in parthenogenetic species.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840635/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840635/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lutes, Aracely A -- Neaves, William B -- Baumann, Diana P -- Wiegraebe, Winfried -- Baumann, Peter -- Howard Hughes Medical Institute/ -- England -- Nature. 2010 Mar 11;464(7286):283-6. doi: 10.1038/nature08818. Epub 2010 Feb 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20173738" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Pairing/*genetics ; Chromosomes/*genetics ; Crossing Over, Genetic/genetics ; Female ; *Heterozygote ; Lizards/*genetics ; Meiosis/genetics ; Microscopy, Electron, Transmission ; Oocytes/cytology/physiology/ultrastructure ; Telomere/genetics
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  • 79
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    Nature Publishing Group (NPG)
    Publication Date: 2010-09-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Bruce E -- England -- Nature. 2010 Sep 23;467(7314):407-8. doi: 10.1038/467407a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20864989" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Fluorescence ; Fluorescent Dyes/analysis/chemistry ; Infrared Rays ; Light ; Microscopy/*methods ; Molecular Imaging/*methods ; Nanoparticles/*analysis/*chemistry ; Particle Size ; Photobleaching ; Photons ; Quantum Dots
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  • 80
    Publication Date: 2010-04-23
    Description: The worldwide prevalence of chronic hepatitis C virus (HCV) infection is estimated to be approaching 200 million people. Current therapy relies upon a combination of pegylated interferon-alpha and ribavirin, a poorly tolerated regimen typically associated with less than 50% sustained virological response rate in those infected with genotype 1 virus. The development of direct-acting antiviral agents to treat HCV has focused predominantly on inhibitors of the viral enzymes NS3 protease and the RNA-dependent RNA polymerase NS5B. Here we describe the profile of BMS-790052, a small molecule inhibitor of the HCV NS5A protein that exhibits picomolar half-maximum effective concentrations (EC(50)) towards replicons expressing a broad range of HCV genotypes and the JFH-1 genotype 2a infectious virus in cell culture. In a phase I clinical trial in patients chronically infected with HCV, administration of a single 100-mg dose of BMS-790052 was associated with a 3.3 log(10) reduction in mean viral load measured 24 h post-dose that was sustained for an additional 120 h in two patients infected with genotype 1b virus. Genotypic analysis of samples taken at baseline, 24 and 144 h post-dose revealed that the major HCV variants observed had substitutions at amino-acid positions identified using the in vitro replicon system. These results provide the first clinical validation of an inhibitor of HCV NS5A, a protein with no known enzymatic function, as an approach to the suppression of virus replication that offers potential as part of a therapeutic regimen based on combinations of HCV inhibitors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gao, Min -- Nettles, Richard E -- Belema, Makonen -- Snyder, Lawrence B -- Nguyen, Van N -- Fridell, Robert A -- Serrano-Wu, Michael H -- Langley, David R -- Sun, Jin-Hua -- O'Boyle, Donald R 2nd -- Lemm, Julie A -- Wang, Chunfu -- Knipe, Jay O -- Chien, Caly -- Colonno, Richard J -- Grasela, Dennis M -- Meanwell, Nicholas A -- Hamann, Lawrence G -- England -- Nature. 2010 May 6;465(7294):96-100. doi: 10.1038/nature08960. Epub 2010 Apr 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Virology, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20410884" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Animals ; Antiviral Agents/blood/chemistry/*pharmacology/therapeutic use ; Cell Line ; Cercopithecus aethiops ; Drug Resistance, Viral ; Female ; Genotype ; HeLa Cells ; Hepacivirus/*drug effects ; Hepatitis C/drug therapy/virology ; Humans ; Imidazoles/blood/chemistry/*pharmacology ; Inhibitory Concentration 50 ; Male ; Middle Aged ; Time Factors ; Vero Cells ; Viral Load/drug effects ; Viral Nonstructural Proteins/*antagonists & inhibitors ; Young Adult
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  • 81
    Publication Date: 2010-08-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cockburn, Andrew -- England -- Nature. 2010 Aug 19;466(7309):930-1. doi: 10.1038/466930a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20725030" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Birds/classification/genetics/*physiology ; *Cooperative Behavior ; Fathers ; Female ; Male ; Models, Biological ; Mothers ; Phylogeny ; Reproduction/genetics/physiology ; Sexual Behavior, Animal/*physiology ; *Siblings
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  • 82
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    Nature Publishing Group (NPG)
    Publication Date: 2010-06-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lydon, John P -- England -- Nature. 2010 Jun 10;465(7299):695-6. doi: 10.1038/465695a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20535190" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Breast Neoplasms/pathology ; Cell Division ; Estrogens/*metabolism ; Estrous Cycle/physiology ; Female ; Humans ; Lactation/physiology ; Mammary Glands, Animal/*cytology ; Mice ; Paracrine Communication ; Pregnancy ; Pregnancy, Animal/physiology ; Progesterone/*metabolism ; RANK Ligand/metabolism ; Receptors, Estrogen/deficiency ; Receptors, Progesterone/deficiency ; Stem Cell Niche/cytology/metabolism ; Stem Cells/*cytology/drug effects/*metabolism
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  • 83
    Publication Date: 2010-02-25
    Description: Tumours with mutant BRAF are dependent on the RAF-MEK-ERK signalling pathway for their growth. We found that ATP-competitive RAF inhibitors inhibit ERK signalling in cells with mutant BRAF, but unexpectedly enhance signalling in cells with wild-type BRAF. Here we demonstrate the mechanistic basis for these findings. We used chemical genetic methods to show that drug-mediated transactivation of RAF dimers is responsible for paradoxical activation of the enzyme by inhibitors. Induction of ERK signalling requires direct binding of the drug to the ATP-binding site of one kinase of the dimer and is dependent on RAS activity. Drug binding to one member of RAF homodimers (CRAF-CRAF) or heterodimers (CRAF-BRAF) inhibits one protomer, but results in transactivation of the drug-free protomer. In BRAF(V600E) tumours, RAS is not activated, thus transactivation is minimal and ERK signalling is inhibited in cells exposed to RAF inhibitors. These results indicate that RAF inhibitors will be effective in tumours in which BRAF is mutated. Furthermore, because RAF inhibitors do not inhibit ERK signalling in other cells, the model predicts that they would have a higher therapeutic index and greater antitumour activity than mitogen-activated protein kinase (MEK) inhibitors, but could also cause toxicity due to MEK/ERK activation. These predictions have been borne out in a recent clinical trial of the RAF inhibitor PLX4032 (refs 4, 5). The model indicates that promotion of RAF dimerization by elevation of wild-type RAF expression or RAS activity could lead to drug resistance in mutant BRAF tumours. In agreement with this prediction, RAF inhibitors do not inhibit ERK signalling in cells that coexpress BRAF(V600E) and mutant RAS.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178447/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178447/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Poulikakos, Poulikos I -- Zhang, Chao -- Bollag, Gideon -- Shokat, Kevan M -- Rosen, Neal -- 1P01CA129243-02/CA/NCI NIH HHS/ -- 2R01EB001987/EB/NIBIB NIH HHS/ -- P01 CA129243-010002/CA/NCI NIH HHS/ -- R01 EB001987/EB/NIBIB NIH HHS/ -- U01 CA091178/CA/NCI NIH HHS/ -- U01 CA091178-01/CA/NCI NIH HHS/ -- England -- Nature. 2010 Mar 18;464(7287):427-30. doi: 10.1038/nature08902.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Program in Molecular Pharmacology and Chemistry and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20179705" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Animals ; Catalytic Domain ; Cell Line ; Cell Line, Tumor ; Enzyme Activation/drug effects ; Extracellular Signal-Regulated MAP Kinases/*metabolism ; Humans ; Indoles/pharmacology ; MAP Kinase Signaling System/*drug effects ; Mice ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Models, Biological ; Neoplasms/drug therapy/enzymology/genetics/metabolism ; Phosphorylation ; Protein Binding ; Protein Kinase Inhibitors/metabolism/*pharmacology/therapeutic use ; Protein Multimerization ; Proto-Oncogene Proteins B-raf/antagonists & ; inhibitors/chemistry/genetics/*metabolism ; Sulfonamides/pharmacology ; Transcriptional Activation/*drug effects ; raf Kinases/*antagonists & inhibitors/chemistry/genetics/*metabolism ; ras Proteins/genetics/metabolism
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  • 84
    Publication Date: 2010-04-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Glausiusz, Josie -- England -- Nature. 2010 Apr 22;464(7292):1118-20. doi: 10.1038/4641118a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20414284" target="_blank"〉PubMed〈/a〉
    Keywords: *Altitude ; Animals ; Desert Climate ; *Ecosystem ; Eutrophication ; Fresh Water/*analysis/chemistry/microbiology ; Indian Ocean ; International Cooperation ; Middle East ; Salinity ; Volatilization ; *Water Supply/analysis/economics/statistics & numerical data
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  • 85
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    Nature Publishing Group (NPG)
    Publication Date: 2010-05-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2010 May 20;465(7296):267. doi: 10.1038/465267a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20485389" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Rights/trends ; Animals ; Animals, Laboratory/anatomy & histology/physiology ; Cognition/*physiology ; Empathy/physiology ; Humans ; Mice ; *Models, Animal ; Neurosciences/*methods/trends ; Prefrontal Cortex/anatomy & histology/physiology ; Primates/*anatomy & histology/*physiology ; Rats
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  • 86
    Publication Date: 2010-06-22
    Description: The molecular clock maintains energy constancy by producing circadian oscillations of rate-limiting enzymes involved in tissue metabolism across the day and night. During periods of feeding, pancreatic islets secrete insulin to maintain glucose homeostasis, and although rhythmic control of insulin release is recognized to be dysregulated in humans with diabetes, it is not known how the circadian clock may affect this process. Here we show that pancreatic islets possess self-sustained circadian gene and protein oscillations of the transcription factors CLOCK and BMAL1. The phase of oscillation of islet genes involved in growth, glucose metabolism and insulin signalling is delayed in circadian mutant mice, and both Clock and Bmal1 (also called Arntl) mutants show impaired glucose tolerance, reduced insulin secretion and defects in size and proliferation of pancreatic islets that worsen with age. Clock disruption leads to transcriptome-wide alterations in the expression of islet genes involved in growth, survival and synaptic vesicle assembly. Notably, conditional ablation of the pancreatic clock causes diabetes mellitus due to defective beta-cell function at the very latest stage of stimulus-secretion coupling. These results demonstrate a role for the beta-cell clock in coordinating insulin secretion with the sleep-wake cycle, and reveal that ablation of the pancreatic clock can trigger the onset of diabetes mellitus.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920067/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920067/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marcheva, Biliana -- Ramsey, Kathryn Moynihan -- Buhr, Ethan D -- Kobayashi, Yumiko -- Su, Hong -- Ko, Caroline H -- Ivanova, Ganka -- Omura, Chiaki -- Mo, Shelley -- Vitaterna, Martha H -- Lopez, James P -- Philipson, Louis H -- Bradfield, Christopher A -- Crosby, Seth D -- JeBailey, Lellean -- Wang, Xiaozhong -- Takahashi, Joseph S -- Bass, Joseph -- P01 AG011412/AG/NIA NIH HHS/ -- P01 AG011412-080011/AG/NIA NIH HHS/ -- R01 HL097817/HL/NHLBI NIH HHS/ -- R01 HL097817-01/HL/NHLBI NIH HHS/ -- R37 ES005703/ES/NIEHS NIH HHS/ -- R37-ES-005703/ES/NIEHS NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2010 Jul 29;466(7306):627-31. doi: 10.1038/nature09253.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20562852" target="_blank"〉PubMed〈/a〉
    Keywords: ARNTL Transcription Factors/deficiency/*genetics/metabolism ; Aging/genetics/pathology ; Animals ; Blood Glucose/analysis/metabolism ; CLOCK Proteins/deficiency/*genetics/metabolism ; Cell Proliferation ; Cell Size ; Cell Survival ; Circadian Rhythm/genetics/*physiology ; Diabetes Mellitus/genetics/*metabolism ; Gene Expression Profiling ; Glucose Intolerance/genetics ; Glucose Tolerance Test ; In Vitro Techniques ; Insulin/*blood/metabolism/secretion ; Islets of Langerhans/*metabolism/pathology/secretion ; Mice ; Period Circadian Proteins/genetics/metabolism ; Phenotype ; Sleep/genetics/physiology ; Synaptic Vesicles/metabolism ; Wakefulness/genetics/physiology
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  • 87
    Publication Date: 2010-01-29
    Description: Cellular differentiation and lineage commitment are considered to be robust and irreversible processes during development. Recent work has shown that mouse and human fibroblasts can be reprogrammed to a pluripotent state with a combination of four transcription factors. This raised the question of whether transcription factors could directly induce other defined somatic cell fates, and not only an undifferentiated state. We hypothesized that combinatorial expression of neural-lineage-specific transcription factors could directly convert fibroblasts into neurons. Starting from a pool of nineteen candidate genes, we identified a combination of only three factors, Ascl1, Brn2 (also called Pou3f2) and Myt1l, that suffice to rapidly and efficiently convert mouse embryonic and postnatal fibroblasts into functional neurons in vitro. These induced neuronal (iN) cells express multiple neuron-specific proteins, generate action potentials and form functional synapses. Generation of iN cells from non-neural lineages could have important implications for studies of neural development, neurological disease modelling and regenerative medicine.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829121/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829121/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vierbuchen, Thomas -- Ostermeier, Austin -- Pang, Zhiping P -- Kokubu, Yuko -- Sudhof, Thomas C -- Wernig, Marius -- 1018438-142-PABCA/PHS HHS/ -- 5T32NS007280/NS/NINDS NIH HHS/ -- T32 CA009302/CA/NCI NIH HHS/ -- U01 HL100397/HL/NHLBI NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2010 Feb 25;463(7284):1035-41. doi: 10.1038/nature08797. Epub 2010 Jan 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Stem Cell Biology and Regenerative Medicine, Department of Pathology, Stanford University School of Medicine, 1050 Arastradero Road, Palo Alto, California 94304, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20107439" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics/metabolism ; Biomarkers/analysis ; Cell Line ; *Cell Lineage ; *Cell Transdifferentiation ; Cells, Cultured ; Embryo, Mammalian/cytology ; Fibroblasts/*cytology ; Mice ; Nerve Tissue Proteins/genetics/metabolism ; Neurons/*cytology/metabolism/*physiology ; POU Domain Factors/genetics/metabolism ; Regenerative Medicine ; Synapses/metabolism ; Tail/cytology ; Time Factors ; Transcription Factors/genetics/metabolism
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  • 88
    Publication Date: 2010-01-08
    Description: The ability to silence the activity of genetically specified neurons in a temporally precise fashion would provide the opportunity to investigate the causal role of specific cell classes in neural computations, behaviours and pathologies. Here we show that members of the class of light-driven outward proton pumps can mediate powerful, safe, multiple-colour silencing of neural activity. The gene archaerhodopsin-3 (Arch) from Halorubrum sodomense enables near-100% silencing of neurons in the awake brain when virally expressed in the mouse cortex and illuminated with yellow light. Arch mediates currents of several hundred picoamps at low light powers, and supports neural silencing currents approaching 900 pA at light powers easily achievable in vivo. Furthermore, Arch spontaneously recovers from light-dependent inactivation, unlike light-driven chloride pumps that enter long-lasting inactive states in response to light. These properties of Arch are appropriate to mediate the optical silencing of significant brain volumes over behaviourally relevant timescales. Arch function in neurons is well tolerated because pH excursions created by Arch illumination are minimized by self-limiting mechanisms to levels comparable to those mediated by channelrhodopsins or natural spike firing. To highlight how proton pump ecological and genomic diversity may support new innovation, we show that the blue-green light-drivable proton pump from the fungus Leptosphaeria maculans (Mac) can, when expressed in neurons, enable neural silencing by blue light, thus enabling alongside other developed reagents the potential for independent silencing of two neural populations by blue versus red light. Light-driven proton pumps thus represent a high-performance and extremely versatile class of 'optogenetic' voltage and ion modulator, which will broadly enable new neuroscientific, biological, neurological and psychiatric investigations.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939492/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939492/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chow, Brian Y -- Han, Xue -- Dobry, Allison S -- Qian, Xiaofeng -- Chuong, Amy S -- Li, Mingjie -- Henninger, Michael A -- Belfort, Gabriel M -- Lin, Yingxi -- Monahan, Patrick E -- Boyden, Edward S -- 1K99MH085944/MH/NIMH NIH HHS/ -- DP2 OD002002/OD/NIH HHS/ -- DP2 OD002002-01/OD/NIH HHS/ -- K99 MH085944/MH/NIMH NIH HHS/ -- K99 MH085944-01/MH/NIMH NIH HHS/ -- England -- Nature. 2010 Jan 7;463(7277):98-102. doi: 10.1038/nature08652.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The MIT Media Laboratory, Synthetic Neurobiology Group, and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20054397" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/radiation effects ; Animals ; Ascomycota/metabolism/radiation effects ; Color ; Electric Conductivity ; Euryarchaeota/metabolism/radiation effects ; Genetic Engineering/*methods ; Hydrogen-Ion Concentration ; Mice ; Molecular Sequence Data ; Neocortex/cytology/physiology/radiation effects ; Neurons/*metabolism/*radiation effects ; Proton Pumps/classification/genetics/*metabolism/*radiation effects ; Rhodopsins, Microbial/antagonists & inhibitors/genetics/metabolism/radiation ; effects ; Wakefulness
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  • 89
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    Nature Publishing Group (NPG)
    Publication Date: 2010-01-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lok, Corie -- England -- Nature. 2010 Jan 28;463(7280):416-8. doi: 10.1038/463416a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20110962" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bibliometrics ; Biomedical Research/*statistics & numerical data ; Data Mining/*methods ; Humans ; Online Systems ; *Periodicals as Topic
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  • 90
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    Unknown
    Nature Publishing Group (NPG)
    Publication Date: 2010-12-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pala, Christopher -- England -- Nature. 2010 Dec 9;468(7325):739-40. doi: 10.1038/468739a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21150962" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Migration ; Animals ; Conservation of Natural Resources/*legislation & jurisprudence/methods ; Ecology/legislation & jurisprudence/methods ; Fisheries/*legislation & jurisprudence/*methods ; *Geography ; Hawaii ; *International Cooperation ; Pacific Ocean ; Population Density ; *Tuna/physiology ; United States
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  • 91
    Publication Date: 2010-10-15
    Description: The evolution and maintenance of sexual reproduction has puzzled biologists for decades. Although this field is rich in hypotheses, experimental evidence is scarce. Some important experiments have demonstrated differences in evolutionary rates between sexual and asexual populations; other experiments have documented evolutionary changes in phenomena related to genetic mixing, such as recombination and selfing. However, direct experiments of the evolution of sex within populations are extremely rare (but see ref. 12). Here we use the rotifer, Brachionus calyciflorus, which is capable of both sexual and asexual reproduction, to test recent theory predicting that there is more opportunity for sex to evolve in spatially heterogeneous environments. Replicated experimental populations of rotifers were maintained in homogeneous environments, composed of either high- or low-quality food habitats, or in heterogeneous environments that consisted of a mix of the two habitats. For populations maintained in either type of homogeneous environment, the rate of sex evolves rapidly towards zero. In contrast, higher rates of sex evolve in populations experiencing spatially heterogeneous environments. The data indicate that the higher level of sex observed under heterogeneity is not due to sex being less costly or selection against sex being less efficient; rather sex is sufficiently advantageous in heterogeneous environments to overwhelm its inherent costs. Counter to some alternative theories for the evolution of sex, there is no evidence that genetic drift plays any part in the evolution of sex in these populations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Becks, Lutz -- Agrawal, Aneil F -- England -- Nature. 2010 Nov 4;468(7320):89-92. doi: 10.1038/nature09449. Epub 2010 Oct 13.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology & Evolutionary Biology, University of Toronto, Toronto, Ontario M5S 3B2, Canada. lutz.becks@utoronto.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20944628" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Migration/physiology ; Animals ; *Biological Evolution ; Diet/veterinary ; *Ecosystem ; Female ; *Food ; Genetic Drift ; Male ; Meiosis/genetics ; Models, Biological ; Ovum/physiology ; Population Density ; Reproduction/physiology ; Reproduction, Asexual/physiology ; Rotifera/cytology/genetics/*physiology ; Selection, Genetic ; *Sex
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 92
    Publication Date: 2010-03-12
    Description: Developing a human immunodeficiency virus (HIV) vaccine is critical to end the global acquired immunodeficiency syndrome (AIDS) epidemic, but many question whether this goal is achievable. Natural immunity is not protective, and despite immunogenicity of HIV vaccine candidates, human trials have exclusively yielded disappointing results. Nevertheless, there is an indication that success may be possible, but this will be dependent on understanding the antiviral immune response in unprecedented depth to identify and engineer the types of immunity required. Here we outline fundamental immunological questions that need to be answered to develop a protective HIV vaccine, and the immediate need to harness a much broader scientific community to achieve this goal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Virgin, Herbert W -- Walker, Bruce D -- England -- Nature. 2010 Mar 11;464(7286):224-31. doi: 10.1038/nature08898.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Washington University School of Medicine and Midwest Regional Center of Excellence for Biodefense and Emerging Infectious Disease Research, Campus Box 8118, 660 South Euclid Avenue, Saint Louis, Missouri 63110, USA. virgin@wustl.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20220841" target="_blank"〉PubMed〈/a〉
    Keywords: *AIDS Vaccines ; Acquired Immunodeficiency Syndrome/*immunology/prevention & control ; Animals ; B-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; HIV/*immunology ; HIV Antibodies/immunology ; Humans ; Mucous Membrane/immunology
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 93
    Publication Date: 2010-06-11
    Description: During early mammalian development, as the pluripotent cells that give rise to all of the tissues of the body proliferate and expand in number, they pass through transition states marked by a stepwise restriction in developmental potential and by changes in the expression of key regulatory genes. Recent findings show that cultured stem-cell lines derived from different stages of mouse development can mimic these transition states. They further reveal that there is a high degree of heterogeneity and plasticity in pluripotent populations in vitro and that these properties are modulated by extrinsic signalling. Understanding the extrinsic control of plasticity will guide efforts to use human pluripotent stem cells in research and therapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pera, Martin F -- Tam, Patrick P L -- England -- Nature. 2010 Jun 10;465(7299):713-20. doi: 10.1038/nature09228.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA. pera@usc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20535200" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Embryonic Stem Cells/cytology/metabolism ; Humans ; Leukemia Inhibitory Factor/metabolism ; Pluripotent Stem Cells/*cytology/*physiology ; Signal Transduction ; Transforming Growth Factor beta/metabolism ; Wnt Proteins/metabolism
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  • 94
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    Nature Publishing Group (NPG)
    Publication Date: 2010-12-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jones, Nicola -- England -- Nature. 2010 Dec 9;468(7325):752-3. doi: 10.1038/468752a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21150970" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bioreactors ; Biotechnology/economics/*methods/*trends ; Chitosan/metabolism ; Conservation of Natural Resources/economics/methods/trends ; Culture Media/chemistry/economics/pharmacology ; Embryonic Stem Cells/cytology ; *Food Supply/economics ; Humans ; Meat/*supply & distribution ; *Muscles/cytology/drug effects ; Organ Culture Techniques/economics/methods/*utilization
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 95
    Publication Date: 2010-08-06
    Description: Long interspersed element-1 (LINE-1 or L1) retrotransposition continues to affect human genome evolution. L1s can retrotranspose in the germline, during early development and in select somatic cells; however, the host response to L1 retrotransposition remains largely unexplored. Here we show that reporter genes introduced into the genome of various human embryonic carcinoma-derived cell lines (ECs) by L1 retrotransposition are rapidly and efficiently silenced either during or immediately after their integration. Treating ECs with histone deacetylase inhibitors rapidly reverses this silencing, and chromatin immunoprecipitation experiments revealed that reactivation of the reporter gene was correlated with changes in chromatin status at the L1 integration site. Under our assay conditions, rapid silencing was also observed when reporter genes were delivered into ECs by mouse L1s and a zebrafish LINE-2 element, but not when similar reporter genes were delivered into ECs by Moloney murine leukaemia virus or human immunodeficiency virus, suggesting that these integration events are silenced by distinct mechanisms. Finally, we demonstrate that subjecting ECs to culture conditions that promote differentiation attenuates the silencing of reporter genes delivered by L1 retrotransposition, but that differentiation, in itself, is not sufficient to reactivate previously silenced reporter genes. Thus, our data indicate that ECs differ from many differentiated cells in their ability to silence reporter genes delivered by L1 retrotransposition.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034402/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034402/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Garcia-Perez, Jose L -- Morell, Maria -- Scheys, Joshua O -- Kulpa, Deanna A -- Morell, Santiago -- Carter, Christoph C -- Hammer, Gary D -- Collins, Kathleen L -- O'Shea, K Sue -- Menendez, Pablo -- Moran, John V -- 5 P30 CA46592/CA/NCI NIH HHS/ -- GM-069985/GM/NIGMS NIH HHS/ -- GM060518/GM/NIGMS NIH HHS/ -- GM082970/GM/NIGMS NIH HHS/ -- NS-048187/NS/NINDS NIH HHS/ -- R01 DK62027/DK/NIDDK NIH HHS/ -- R01 GM060518/GM/NIGMS NIH HHS/ -- R01 GM060518-12/GM/NIGMS NIH HHS/ -- R01 GM082970/GM/NIGMS NIH HHS/ -- R01 GM082970-04/GM/NIGMS NIH HHS/ -- R01AI051198/AI/NIAID NIH HHS/ -- T32-GM08322/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2010 Aug 5;466(7307):769-73. doi: 10.1038/nature09209.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Human Genetics, 1241 East Catherine Street, University of Michigan Medical School, Ann Arbor, Michigan 48109-5618, USA. josel.garcia.perez@juntadeandalucia.es〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20686575" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation/genetics/physiology ; Cell Line, Tumor ; Chromatin/drug effects/genetics/metabolism ; Chromatin Immunoprecipitation ; Embryonal Carcinoma Stem Cells/*metabolism/pathology ; Epigenesis, Genetic/drug effects/*genetics ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; *Gene Silencing/drug effects ; Genes, Reporter/genetics ; Genetic Engineering ; Genetic Vectors/genetics ; Genome, Human/genetics ; HIV/genetics ; Histone Deacetylase Inhibitors/pharmacology ; Humans ; Long Interspersed Nucleotide Elements/genetics ; Male ; Mice ; Models, Genetic ; Moloney murine leukemia virus/genetics ; Retroelements/*genetics ; Zebrafish/genetics
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  • 96
    Publication Date: 2010-10-01
    Description: Breast cancer is one of the most common cancers in humans and will on average affect up to one in eight women in their lifetime in the United States and Europe. The Women's Health Initiative and the Million Women Study have shown that hormone replacement therapy is associated with an increased risk of incident and fatal breast cancer. In particular, synthetic progesterone derivatives (progestins) such as medroxyprogesterone acetate (MPA), used in millions of women for hormone replacement therapy and contraceptives, markedly increase the risk of developing breast cancer. Here we show that the in vivo administration of MPA triggers massive induction of the key osteoclast differentiation factor RANKL (receptor activator of NF-kappaB ligand) in mammary-gland epithelial cells. Genetic inactivation of the RANKL receptor RANK in mammary-gland epithelial cells prevents MPA-induced epithelial proliferation, impairs expansion of the CD49f(hi) stem-cell-enriched population, and sensitizes these cells to DNA-damage-induced cell death. Deletion of RANK from the mammary epithelium results in a markedly decreased incidence and delayed onset of MPA-driven mammary cancer. These data show that the RANKL/RANK system controls the incidence and onset of progestin-driven breast cancer.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084017/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084017/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schramek, Daniel -- Leibbrandt, Andreas -- Sigl, Verena -- Kenner, Lukas -- Pospisilik, John A -- Lee, Heather J -- Hanada, Reiko -- Joshi, Purna A -- Aliprantis, Antonios -- Glimcher, Laurie -- Pasparakis, Manolis -- Khokha, Rama -- Ormandy, Christopher J -- Widschwendter, Martin -- Schett, Georg -- Penninger, Josef M -- HD055601/HD/NICHD NIH HHS/ -- R01 HD055601/HD/NICHD NIH HHS/ -- R01 HD055601-04/HD/NICHD NIH HHS/ -- England -- Nature. 2010 Nov 4;468(7320):98-102. doi: 10.1038/nature09387. Epub 2010 Sep 29.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20881962" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis/radiation effects ; Cell Differentiation ; Cell Proliferation/drug effects ; DNA Damage ; Epithelial Cells/cytology/drug effects/metabolism/radiation effects ; Female ; Gamma Rays ; Integrin alpha6/metabolism ; Mammary Neoplasms, Experimental/*chemically ; induced/genetics/metabolism/*pathology ; Medroxyprogesterone Acetate/administration & dosage/adverse effects ; Mice ; NF-kappa B/metabolism ; Osteoclasts/cytology ; Phosphoproteins/analysis/immunology ; Progestins/administration & dosage/*adverse effects ; RANK Ligand/deficiency/genetics/*metabolism ; Receptor Activator of Nuclear Factor-kappa B/deficiency/genetics/metabolism ; Signal Transduction ; Stem Cells/cytology/drug effects/metabolism
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  • 97
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    Nature Publishing Group (NPG)
    Publication Date: 2010-05-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Qiu, Jane -- England -- Nature. 2010 May 20;465(7296):284-6. doi: 10.1038/465284a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20485410" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Migration ; Animals ; *Biodiversity ; *Biological Evolution ; Geography ; Hot Springs/microbiology ; Larva/genetics/physiology ; *Marine Biology ; Mexico ; Oceanography ; Oceans and Seas ; Population Dynamics ; *Volcanic Eruptions/adverse effects ; Water Movements
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 98
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    Unknown
    Nature Publishing Group (NPG)
    Publication Date: 2010-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dalton, Rex -- England -- Nature. 2010 Mar 25;464(7288):472-3. doi: 10.1038/464472a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20336101" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; DNA, Mitochondrial/genetics ; *Finger Phalanges ; *Fossils ; Hominidae/*classification/genetics ; Humans ; Siberia
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  • 99
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    Unknown
    Nature Publishing Group (NPG)
    Publication Date: 2010-07-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kher, Unmesh -- England -- Nature. 2010 Jul 15;466(7304):S21-2. doi: 10.1038/nature09245.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉International AIDS Vaccine Initiative.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20631702" target="_blank"〉PubMed〈/a〉
    Keywords: AIDS Vaccines ; Allergy and Immunology ; Animals ; Anti-HIV Agents/administration & dosage/supply & distribution/therapeutic use ; Biomedical Research/economics/manpower/*organization & administration/trends ; Computational Biology ; Disease Progression ; Drug Combinations ; Financing, Organized/economics ; HIV/drug effects/enzymology/genetics/isolation & purification ; HIV Infections/drug therapy/immunology/*therapy/virology ; Humans ; *Interdisciplinary Communication ; Mice ; Models, Animal ; Research Personnel/*organization & administration/trends ; Research Support as Topic/economics/organization & administration ; Systems Biology ; Treatment Outcome ; Viral Load
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  • 100
    Publication Date: 2010-11-19
    Description: Biodiversity indicators provide a vital window on the state of the planet, guiding policy development and management. The most widely adopted marine indicator is mean trophic level (MTL) from catches, intended to detect shifts from high-trophic-level predators to low-trophic-level invertebrates and plankton-feeders. This indicator underpins reported trends in human impacts, declining when predators collapse ("fishing down marine food webs") and when low-trophic-level fisheries expand ("fishing through marine food webs"). The assumption is that catch MTL measures changes in ecosystem MTL and biodiversity. Here we combine model predictions with global assessments of MTL from catches, trawl surveys and fisheries stock assessments and find that catch MTL does not reliably predict changes in marine ecosystems. Instead, catch MTL trends often diverge from ecosystem MTL trends obtained from surveys and assessments. In contrast to previous findings of rapid declines in catch MTL, we observe recent increases in catch, survey and assessment MTL. However, catches from most trophic levels are rising, which can intensify fishery collapses even when MTL trends are stable or increasing. To detect fishing impacts on marine biodiversity, we recommend greater efforts to measure true abundance trends for marine species, especially those most vulnerable to fishing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Branch, Trevor A -- Watson, Reg -- Fulton, Elizabeth A -- Jennings, Simon -- McGilliard, Carey R -- Pablico, Grace T -- Ricard, Daniel -- Tracey, Sean R -- England -- Nature. 2010 Nov 18;468(7322):431-5. doi: 10.1038/nature09528.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Aquatic and Fishery Sciences, Box 355020, University of Washington, Seattle, Washington 98195-5020, USA. tbranch@uw.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21085178" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aquatic Organisms/*isolation & purification/*metabolism ; Biodiversity ; Biomass ; Databases, Factual ; *Ecosystem ; Environmental Policy ; *Fisheries ; *Fishes/metabolism ; Food Chain ; Human Activities ; Invertebrates/metabolism ; Models, Biological ; Plankton/metabolism
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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