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  • 1
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    Origin of the human malaria parasite Plasmodium falciparum in gorillas (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-09-25
    Description: Plasmodium falciparum is the most prevalent and lethal of the malaria parasites infecting humans, yet the origin and evolutionary history of this important pathogen remain controversial. Here we develop a single-genome amplification strategy to identify and characterize Plasmodium spp. DNA sequences in faecal samples from wild-living apes. Among nearly 3,000 specimens collected from field sites throughout central Africa, we found Plasmodium infection in chimpanzees (Pan troglodytes) and western gorillas (Gorilla gorilla), but not in eastern gorillas (Gorilla beringei) or bonobos (Pan paniscus). Ape plasmodial infections were highly prevalent, widely distributed and almost always made up of mixed parasite species. Analysis of more than 1,100 mitochondrial, apicoplast and nuclear gene sequences from chimpanzees and gorillas revealed that 99% grouped within one of six host-specific lineages representing distinct Plasmodium species within the subgenus Laverania. One of these from western gorillas comprised parasites that were nearly identical to P. falciparum. In phylogenetic analyses of full-length mitochondrial sequences, human P. falciparum formed a monophyletic lineage within the gorilla parasite radiation. These findings indicate that P. falciparum is of gorilla origin and not of chimpanzee, bonobo or ancient human origin.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997044/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997044/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, Weimin -- Li, Yingying -- Learn, Gerald H -- Rudicell, Rebecca S -- Robertson, Joel D -- Keele, Brandon F -- Ndjango, Jean-Bosco N -- Sanz, Crickette M -- Morgan, David B -- Locatelli, Sabrina -- Gonder, Mary K -- Kranzusch, Philip J -- Walsh, Peter D -- Delaporte, Eric -- Mpoudi-Ngole, Eitel -- Georgiev, Alexander V -- Muller, Martin N -- Shaw, George M -- Peeters, Martine -- Sharp, Paul M -- Rayner, Julian C -- Hahn, Beatrice H -- P30 AI 7767/AI/NIAID NIH HHS/ -- P30 AI027767/AI/NIAID NIH HHS/ -- P30 AI027767-21A1/AI/NIAID NIH HHS/ -- R01 AI058715/AI/NIAID NIH HHS/ -- R01 AI058715-06A1/AI/NIAID NIH HHS/ -- R01 AI058715-07/AI/NIAID NIH HHS/ -- R01 AI50529/AI/NIAID NIH HHS/ -- R01 I58715/PHS HHS/ -- R03 AI074778/AI/NIAID NIH HHS/ -- R03 AI074778-02/AI/NIAID NIH HHS/ -- R37 AI050529/AI/NIAID NIH HHS/ -- R37 AI050529-07/AI/NIAID NIH HHS/ -- R37 AI050529-08/AI/NIAID NIH HHS/ -- T32 AI007245/AI/NIAID NIH HHS/ -- T32 AI007245-26/AI/NIAID NIH HHS/ -- T32 GM008111/GM/NIGMS NIH HHS/ -- T32 GM008111-13/GM/NIGMS NIH HHS/ -- U19 AI 067854/AI/NIAID NIH HHS/ -- U19 AI067854/AI/NIAID NIH HHS/ -- U19 AI067854-06/AI/NIAID NIH HHS/ -- Howard Hughes Medical Institute/ -- Wellcome Trust/United Kingdom -- England -- Nature. 2010 Sep 23;467(7314):420-5. doi: 10.1038/nature09442.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20864995" target="_blank"〉PubMed〈/a〉
    Keywords: Africa/epidemiology ; Animals ; Animals, Wild/classification/parasitology ; Ape Diseases/epidemiology/*parasitology/transmission ; DNA, Mitochondrial/analysis/genetics ; Evolution, Molecular ; Feces/parasitology ; Genes, Mitochondrial/genetics ; Genetic Variation/genetics ; Genome, Protozoan/genetics ; Gorilla gorilla/classification/*parasitology ; Humans ; Malaria, Falciparum/epidemiology/*parasitology/transmission/*veterinary ; Molecular Sequence Data ; Pan paniscus/parasitology ; Pan troglodytes/parasitology ; Phylogeny ; Plasmodium/classification/genetics/isolation & purification ; Plasmodium falciparum/genetics/*isolation & purification ; Prevalence ; Zoonoses/parasitology/transmission
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
    Electronic Resource
    Electronic Resource
    Sulphinpyrazone and renal function following myocardial infarction (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 747-750 
    Details
    ISSN: 1432-1041
    Keywords: sulphinpyrazone ; myocardial infarction ; renal function ; uric acid excretion ; prognostic implications
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of sulphinpyrazone 800 mg daily on renal excretory function were studied in a double-blind placebo-controlled randomised trial of incremental and full doses of the drug in 28 patients with plasma urea concentration 〈10 mmol/l in the period 2–28 days following uncomplicated acute myocardial infarction. Sulphinpyrazone in both dosage regimens increased uric acid excretion and lowered plasma urate concentration. There was no evidence that the drug reduced glomerular filtration rate or damaged the renal tubules. These results suggest that sulphinpyrazone in the doses used in this study is not contraindicated in patients early after acute myocardial infarction even though they may have a moderate rise in the blood urea.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607081
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  • 3
    Electronic Resource
    Electronic Resource
    Influence of dichloromethylene diphosphonate (Cl2MDP) and calcitonin on bone resorption, lactate production and phosphatase and pyrophosphatase content of mouse calvaria treated with parathyroid hormonein vitro (1973)
    Springer
    Calcified tissue international 13 (1973), S. 287-294 
    Details
    ISSN: 1432-0827
    Keywords: Diphosphonates ; Calcitonin ; Parathyroid hormone ; Bone resorption ; Tissue culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé L'effet de la parathormone, de la calcitonine et du dichloromethylenediphosphonate sur la résorption osseuse, la production de lactate et le contenu en phosphatases alcaline et acide aussi bien que celui en pyrophosphatases alcaline, neutre et acide dans une culture de calvaria de souris a été étudié. La parathormone augmente touts ces paramètres. La calcitonine prévient l'augmentation de la libération du45Calcium et du lactate, mais ne prévient pas l'augmentation des différents enzymes. Le diphosphonate lui prévient en plus l'augmentation de la phosphatase et pyrophosphatase acide.
    Abstract: Zusammenfassung Die Wirkung von Parathormon, Calcitonin und Dichloromethylen-Diphosphonat auf Knockenresorption, Lactatbildung und den Gehalt an alkalischer und saurer Phosphatase sowie an alkalischer, neutraler und saurer Pyrophosphatase in gezüchteten Mäuse-Calvarien wurde untersucht. Parathormon erhöhte alle diese Parameter, Calcitonin verhinderte die Erhöhung von45Calcium-und Lactatfreisetzung, aber nicht die Zunahme der verschiedenen Enzyme. Das Diphosphonat jedoch verhinderte zudem noch die Erhöhung der sauren Phosphatase und Pyrophosphatase.
    Notes: Abstract The effect of parathyroid hormone, calcitonin and dichloromethylenediphosphonate (Cl2MDP) on bone resorption, lactate production and the content of alkaline and acid phosphatases and alkaline neutral and acid pyrophosphatases in mouse calvaria in culture was investigated. Parathyroid hormone increased all measured variables. Calcitonin prevented the increase in45Ca release and lactate production but not the increase in the various enzymes. The diphosphonate prevented the increase in45Ca release and lactate production but in addition prevented the increase in acid phosphatase and pyrophosphatase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02015418
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  • 4
    Electronic Resource
    Electronic Resource
    The effect of two diphosphonates on the resorption of mouse calvariain vitro (1972)
    Springer
    Calcified tissue international 10 (1972), S. 302-313 
    Details
    ISSN: 1432-0827
    Keywords: Diphosphonates ; Bone resorption ; Mouse ; Pyrophosphate ; Tissue culture ; 45Calcium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé Deux diphosphonates, le disodium-éthane-1-hydroxyle-1,1-diphosphonate (EHDP) et le disodium dichlorométhylène diphosphonate (Cl2MDP), inhibent la résorption osseuse, induite par des cellules au niveau de calottes craniennes, cultivées pendant 48 heuresin vitro, lorsque ces substances sont ajoutées au milieu. Le Cl2MDP est plus actif que l'EHDP, à des doses variant 0–16 μg P/ml. Le pyrophosphate et l'imidodiphosphate n'inhibent pas la résorption osseuse à des doses comparables. Lorsque les deux diphosphonates sont injectés à des sourisin vivo avant mise en culture, la résorption osseuse observéein vitro est considérablement réduite: à une dose de 10 μg P/g de poids corporel de Cl2MDP, elle est presque totalement inhibée. Cet effet est rapide et dure plusieurs jours. Les conséquences de ces résultats et la méthode d'essai d'inhibiteurs de la résorption osseuse par la méthode combinéein vivo/ in vitro sont envisagées.
    Abstract: Zusammenfassung Zwei Diphosphonate, Dinatrium-äthan-1-hydroxy-1,1-diphosphonat (EHDP) und Dinatrium-Dichloromethylendiphosphonat (Cl2MDP), hemmen zellbedingte Knochenresorption von Mäuseschädeldächern, welche während 48 Stdin vitro kultiviert worden waren, wenn diese Substanzen dem Nährmedium zugegeben werden. Im Dosierungsbereich von 0–16 μg P/ml ist Cl2MDP wirksamer als EHDP. Pyrophosphat und Imidodiphosphat blockieren die Knochenresorption bei entsprechenden Dosen nicht. Wenn die zwei Diphosphonate Mäusenin vivo injiziert werden, bevor das Explantat hergestellt wird, ist die nachfolgende Knochenresorptionin vitro stark vermindert; bei einer Dosierung von 10 μg P/g Körpergewicht von Cl2MDP ist die Resorption fast gänzlich blockiert. Diese Wirkung erfolgt rasch und dauert während einigen Tagen an. Die Folgerungen aus diesen Ergebnissen sowie das Verfahren, Knochenresorptionshemmer mittels kombinierterin vivo/in vitro-Methode zu prüfen, werden diskutiert.
    Notes: Abstract Two diphosphonates, disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) and disodium dichloromethyle diphosphonate (Cl2MDP), inhibit cell-mediated bone resorption of mouse calvaria cultivated for 48 hoursin vitro, when the compounds are added to the medium. Cl2MDP is more effective than EHDP over the dose range 0–16 μg P/ml. Pyrophosphate and imidodiophosphate do not block bone resorption at comparable dose levels. When the two diphosphonates are injected into micein vivo before explants are prepared, subsequent bone resorptionin vitro is considerably reduced; at a dose level of 10 μg P/g body weight of Cl2MDP it is almost completely blocked. This effect is rapid and persists for several days. The implications of these results and the method of testing inhibitors of bone resorption by the combinedin vivo/in vitro method are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02012561
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  • 5
    Electronic Resource
    Electronic Resource
    Inhibition by diphosphonates of bone resorption in mice and comparison with grey-lethal osteopetrosis (1973)
    Springer
    Calcified tissue international 12 (1973), S. 59-71 
    Details
    ISSN: 1432-0827
    Keywords: Osteopetrosis ; Diphosphonates ; Bone Resorption ; Mouse ; Calcium ; Tooth ; Bone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé L'effet de doses quotidiennes, administrées depuis la naissance, de deux types de diphosphonates, à savoir l'éthane-1-hydroxyle-1,1-diphosphonate (EHDP) et le dichlorométhylène diphosphonate (Cl2MDP), sur la croissance et le squelette de souris a été étudié. Les diphosphonates freinent la croissance: les incisives ne font pas leur éruption ou elle est plus tardive. La calcémie est normale. L'administration de Cl2MDP à une dose quotidienne de 10 mg P/kg/jour provoque des modifications squelettiques identiques à celles des souris grises létales atteintes d'ostéopétrose et les animaux meurent après quatre semaines de traitement. Par rapport aux témoins, les souris traitées présentent des os plus étroits, plus denses et plus déformés: les cavités médullaires sont comblées avec de l'os calcifié et du cartilage. La quantité totale de calcium d'un animal n'est pas augmentée par traitement au diphosphonate, par rapport à un témoin de même âge. Chez les souris grises létales et celles traitées aux diphosphonates, la plupart des anomalies est secondaire à une résorption osseuse diminuée. Ces résultats sont commentés en fonction de l'emploi des diphosphonates au cours de remaniements osseux pathologiques augmentés et en fonction du rôle de la résorption osseuse dans le maintien de la calcémie.
    Abstract: Zusammenfassung Mäuse erhielten von der Geburt an tägliche Dosen folgender zwei Diphosphonate: entweder Äthan-1-Hydroxy-1,1-Diphosphonat (EHDP) oder Dichloromethylen-Diphosphonat (Cl2MDP). Es wurde deren Wirkung auf das Wachstum und das Skelet untersucht. Die Diphosphonate verlangsamten das Wachstum, die Schneidezähne brachen nicht oder erst später durch, aber die Höhe des Plasmacalciums blieb normal. Die Verabreichung von Cl2MDP in Dosen von 10 mg P/kg/Tag führt zu Skeletveränderungen, welche denjenigen der „grey-lethal” osteopetrotischen Mäuse gleichen. Die Tiere sterben nach einer Behandlungsdauer von etwa 4 Wochen. Verglichen mit normalen Mäusen von ungefähr gleichem Alter hatten die behandelten Mäuse kleinere, dichtere und mehr keulenförmige Knochen, und die Markhöhlen waren gefüllt mit verkalktem Knochen oder Knorpel. Die Gesamtcalciummenge im Skelet wurde durch die Diphosphonatbehandlung nicht erhöht; dies ergab sich aus einem Vergleich mit der bei normalen Mäusen desselben Alters gefundenen Menge. Es wird vorgeschlagen, daß bei den „grey-lethal” und bei den Diphosphonat-behandelten Mäusen viele der Abnormalitäten als Folge der herabgesetzten Knochenresorption angesehen werden müssen. Die Ergebnisse werden einerseits im Hinblick auf den Gebrauch der Diphosphonate bei pathologischen Bedingungen eines erhöhten Knochenumbaus diskutiert; andererseits werden sie im Zusammenhang mit der Rolle der Knochenresorption bei der Erhaltung des Plasmacalcium-Spiegels besprochen.
    Notes: Abstract The effect of daily doses from birth of two diphosphonates, namely either ethane-1-hydroxy-1,1-diphosphonate (EHDP) or dichloromethylene diphosphonate (Cl2MDP), on the growth and the skeleton of mice has been studied. Diphosphonates slowed growth, the incisors did not erupt or erupted later, but the level of plasma calcium remained normal. The administration of Cl2MDP at a dose rate of 10 mg P/kg/day leads to skeletal changes that are similar to those observed in grey-lethal osteopetrotic mice, and the animals die after about four weeks of treatment. As compared with normal mice of similar age, treated mice had bones that were smaller, denser and more clubshaped, and the marrow cavities were filled with calcified bone or cartilage. The total amount of calcium in the carcass was not increased by diphosphonate treatment, as compared with the amount in normal mice of the same age. It is suggested that both in the grey-lethal and diphosphonate-treated mice many of the abnormalities are secondary to decreased bone resorption. The results are discussed with respect to the use of diphosphonates in pathological conditions of increased bone turnover and with respect to the role of bone resorption in the maintenance of plasma calcium levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02013722
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  • 6
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    Short isoform of HVCN1 is enriched in CLL B cells [Physiology] (2014)
    National Academy of Sciences
    Details
    Publication Date: 2014-12-17
    Description: HVCN1 (Hydrogen voltage-gated channel 1) is the only mammalian voltage-gated proton channel. In human B lymphocytes, HVCN1 associates with the B-cell receptor (BCR) and is required for optimal BCR signaling and redox control. HVCN1 is expressed in malignant B cells that rely on BCR signaling, such as chronic lymphocytic leukemia...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 7
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    Guns, germs, and trees determine density and distribution of gorillas and chimpanzees in Western Equatorial Africa (2018)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2018-04-26
    Description: We present a range-wide assessment of sympatric western lowland gorillas Gorilla gorilla gorilla and central chimpanzees Pan troglodytes troglodytes using the largest survey data set ever assembled for these taxa: 59 sites in five countries surveyed between 2003 and 2013, totaling 61,000 person-days of fieldwork. We used spatial modeling to investigate major drivers of great ape distribution and population trends. We predicted density across each taxon’s geographic range, allowing us to estimate overall abundance: 361,900 gorillas and 128,700 chimpanzees in Western Equatorial Africa—substantially higher than previous estimates. These two subspecies represent close to 99% of all gorillas and one-third of all chimpanzees. Annual population decline of gorillas was estimated at 2.7%, maintaining them as Critically Endangered on the International Union for Conservation of Nature and Natural Resources (IUCN) Red List. We quantified the threats to each taxon, of which the three greatest were poaching, disease, and habitat degradation. Gorillas and chimpanzees are found at higher densities where forest is intact, wildlife laws are enforced, human influence is low, and disease impacts have been low. Strategic use of the results of these analyses could conserve the majority of gorillas and chimpanzees. With around 80% of both subspecies occurring outside protected areas, their conservation requires reinforcement of anti-poaching efforts both inside and outside protected areas (particularly where habitat quality is high and human impact is low), diligent disease control measures (including training, advocacy, and research into Ebola virus disease), and the preservation of high-quality habitat through integrated land-use planning and implementation of best practices by the extractive and agricultural industries.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Sulphinpyrazone and renal function following myocardial infarction (1983)
    Springer
    Details
    Publication Date: 1983-01-01
    Print ISSN: 0031-6970
    Electronic ISSN: 1432-1041
    Topics: Chemistry and Pharmacology , Medicine
    Published by Springer
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  • 9
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    Clinical application of measurements of body composition (1982)
    Institute of Physics
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    Publication Date: 1982-05-01
    Print ISSN: 0143-0815
    Topics: Medicine , Physics
    Published by Institute of Physics
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  • 10
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    Goddard Brouwer Orbit Bulletin (1971)
    In:  CASI
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    Publication Date: 2019-06-27
    Description: The bulletin provides operational support for earth space research and technological missions by producing a tape containing pertinent spacecraft orbital information which is provided to a number of cities around the world in support of individual missions. A program description of the main and associated subroutines, and a complete description of the input, output and requirements of the bulletin program are presented.
    Keywords: SPACE SCIENCES
    Type: NASA-TM-X-66141 , X-552-72-368
    Format: application/pdf
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    NASA TECHNICAL REPORTS
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