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  • Mice  (83)
  • Time Factors  (38)
  • Rats, Inbred Strains
  • American Association for the Advancement of Science (AAAS)  (119)
  • Annual Reviews
  • Blackwell Publishing Ltd
  • 1980-1984  (119)
  • 1955-1959
  • 1980  (119)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (119)
  • Annual Reviews
  • Blackwell Publishing Ltd
  • Springer  (4)
Years
  • 1980-1984  (119)
  • 1955-1959
Year
  • 1
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    L-Ornithine decarboxylase:an essential role in early mammalian embryogenesis (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-05-02
    Description: The highly selective, enzyme-activated, irreversible inhibitor of L-ornithine decarboxylase, DL-alpha-difluoromethylornithine, suppresses the increase in uterine L-ornithine decarboxylase activity associated with early embryogenesis in the mouse and arrests embryonic development at that stage. Contragestational effects were confirmed in the rat and rabbit. An increase in L-ornithine decarboxylase activity that leads to a rapid increase in putrescine concentration appears to be essential during a critical period after implantation for continued mammalian embryonal growth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fozard, J R -- Part, M L -- Prakash, N J -- Grove, J -- Schechter, P J -- Sjoerdsma, A -- Koch-Weser, J -- New York, N.Y. -- Science. 1980 May 2;208(4443):505-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6768132" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosylmethionine Decarboxylase/metabolism ; Animals ; Carboxy-Lyases/*physiology ; Eflornithine ; Embryo, Mammalian/drug effects/*physiology ; Female ; Gestational Age ; Mice ; Ornithine/*analogs & derivatives/pharmacology ; Ornithine Decarboxylase/*physiology ; Ornithine Decarboxylase Inhibitors ; Polyamines/metabolism ; Pregnancy ; Rabbits ; Rats ; Uterus/drug effects/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Interaction of laminae of the cingulate cortex with the anteroventral thalamus during behavioral learning (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-05-30
    Description: Neurons in deep laminae of the rabbit cingulate cortex develop discriminative activity at an early stage of behavioral discrimination learning, whereas neurons in the anteroventral nucleus of thalamus and neurons in the superficial cortical laminae develop such activity in a late stage of behavioral learning. It is hypothesized that early-forming discriminative neuronal activity, relayed to anteroventral neurons via the corticothalamic pathway, contributes to the construction of changes underlying the late-forming neuronal discrimination in the anteroventral nucleus. The resultant late discriminative activity in the anteroventral nucleus is then relayed via the thalamocortical pathway back to the superficial cortical laminae, promoting disengagement of cortex from further task-processing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gabriel, M -- Foster, K -- Orona, E -- New York, N.Y. -- Science. 1980 May 30;208(4447):1050-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7375917" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Avoidance Learning/*physiology ; Brain Mapping ; Cerebral Cortex/cytology/*physiology ; Discrimination (Psychology)/*physiology ; Gyrus Cinguli/*physiology ; Neural Pathways/physiology ; Rabbits ; Thalamus/*physiology ; Time Factors
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Doridosine: a new hypotensive N-methylpurine riboside from the nudibranch Anisodoris nobilis (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-11
    Description: A new N-methylpurine riboside (doridosine), probably N1-Methylisoguanosine, was isolated from the digestive glands of a nudibranch. Doridosine produces prolonged hypotension and bradycardia in anesthetized rats, decreases the rate and the amplitude of contraction of guinea pig atria in vitro, and causes the heart rate in anesthetized mice to be reduced by 50 percent for many hours after which the animals recover completely.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fuhrman, F A -- Fuhrman, G J -- Kim, Y H -- Pavelka, L A -- Mosher, H S -- New York, N.Y. -- Science. 1980 Jan 11;207(4427):193-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7350655" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antihypertensive Agents/*isolation & purification ; Guanosine/*analogs & derivatives/isolation & purification/pharmacology ; Guinea Pigs ; Heart Rate/drug effects ; Mice ; Mollusca/analysis ; Rats
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Survival of mice receiving melanoma transplants is promoted by hydroquinone (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-04-25
    Description: In BALB/c female mice with melanoma transplants, the incidence of "takes" is decreased and survival is increased by hydroquinone, a melanocytolytic agent. The mechanism of drug action is suggested by via DNA. The significant and high degree of positive response to hydroquinone treatment in vivo is encouraging for the clinical management of melanoma with melanocytolytic agents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chavin, W -- Jelonek, E J Jr -- Reed, A H -- Binder, L R -- New York, N.Y. -- Science. 1980 Apr 25;208(4442):408-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7367868" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Female ; Hydroquinones/metabolism/*therapeutic use ; Melanocytes/metabolism ; Melanoma/*drug therapy ; Mice ; Neoplasm Transplantation ; Neoplasms, Experimental/drug therapy
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Preserved learning and retention of pattern-analyzing skill in amnesia: dissociation of knowing how and knowing that (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-10
    Description: Amnesic patients acquired a mirror-reading skill at a rate equivalent to that of matched control subjects and retained it for at least 3 months. The results indicate that the class of preserved learning skills in amnesia is broader than previously reported. Amnesia seems to spare information that is based on rules or procedures, as contrasted with information that is data-based or declarative--"knowing how rather than "knowing that." The results support the hypothesis that such a distinction is honored by the nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, N J -- Squire, L R -- 1P50 MH 30914/MH/NIMH NIH HHS/ -- MH24600/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1980 Oct 10;210(4466):207-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7414331" target="_blank"〉PubMed〈/a〉
    Keywords: Alcohol Amnestic Disorder/physiopathology ; Amnesia/*physiopathology ; Electroconvulsive Therapy ; *Form Perception ; Humans ; Learning/*physiology ; *Pattern Recognition, Visual ; Reading ; Retention (Psychology)/physiology ; Time Factors
    Print ISSN: 0036-8075
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  • 6
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    Testosterone-mediated sexual dimorphism of mitochondria and lysosomes in mouse kidney proximal tubules (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-29
    Description: In kidney proximal tubules of male mice the mitochondria are larger and more electron-lucent, autophagic vacuoles and lysosomes (predominantly myeloid bodies) more numerous and voluminous, and exocytosed intraluminal myeloid bodies more common than in females. Males also have higher kidney activities of mitochondrial cytochrome c oxidase and lysosomal hydrolases, and excrete larger quantities of hydrolases and protein in the urine. Orchiectomy evokes the feminine pattern whereas testosterone administration induces the male pattern. Endogenous testosterone modulates mitochondrial structure and function and enhances the activity of the lysosomal-vacuolar system in proximal tubule cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koenig, H -- Goldstone, A -- Blume, G -- Lu, C Y -- New York, N.Y. -- Science. 1980 Aug 29;209(4460):1023-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7403864" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Castration ; Enzymes/urine ; Female ; Kidney/drug effects ; Kidney Tubules, Proximal/*ultrastructure ; Lysosomes/drug effects/enzymology ; Male ; Mice ; Mitochondria/drug effects/enzymology ; Organ Size/drug effects ; Sex Differentiation/*drug effects ; Testosterone/*pharmacology
    Print ISSN: 0036-8075
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  • 7
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    Tooth induction in chick epithelium: expression of quiescent genes for enamel synthesis (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-29
    Description: Intraocular grafts of chick epithelium combined with mouse molar mesenchyme produced a variety of dental structures including perfectly formed crowns with differentiated ameloblasts depositing enamel matrix. The results suggest that the loss of teeth in Aves did not result from a loss of genetic coding for enamel synthesis in the oral epithelium but from an alteration in the tissue interactions requisite for odontogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kollar, E J -- Fisher, C -- New York, N.Y. -- Science. 1980 Feb 29;207(4434):993-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7352302" target="_blank"〉PubMed〈/a〉
    Keywords: *Amelogenesis ; Animals ; Chick Embryo/*cytology ; Culture Techniques ; Dental Enamel Proteins/*biosynthesis/genetics ; Embryonic Induction ; Epithelial Cells ; Genes ; Mandible/cytology ; Mesoderm/cytology ; Mice ; *Odontogenesis
    Print ISSN: 0036-8075
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  • 8
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    Role of the spleen in the growth of a murine B cell leukemia (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-04-04
    Description: A spontaneous B cell leukemia (BCL1) grew progressively in normal BALB/c mice after injection of tumor cells but did not grow in splenectomized recipients. Despite the absence of progressive tumor growth, residual tumor cells with malignant potential were found in the peripheral blood of the splenectomized animals. Splenectomy performed after injection of tumor cells but before the development of marked leukocytosis also prevented progressive tumor growth and death of the host. Thus the spleen appears to be necessary for progressive proliferation of this lymphocytic leukemia early after passage in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kotzin, B L -- Strober, S -- New York, N.Y. -- Science. 1980 Apr 4;208(4439):59-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6965803" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes/*pathology ; Disease Models, Animal ; Female ; Leukemia, Experimental/etiology/physiopathology ; Leukemia, Lymphoid/*etiology/physiopathology ; Mice ; Mice, Inbred BALB C ; Spleen/*physiology ; Splenectomy
    Print ISSN: 0036-8075
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  • 9
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    Prolongation of islet xenograft survival without continuous immunosuppression (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-11
    Description: The survival of isolated rat islets transplanted into diabetic mice was prolonged markedly by maintaining the rat islets in vitro at 24 degrees C for 7 days before transplantation and administering to the recipients a single injection of antiserum to mouse and rat lymphocytes shortly before transplantation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lacy, P E -- Davie, J M -- Finke, E H -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):283-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6770465" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Glucose/analysis ; Cell Survival ; Cells, Cultured ; Diabetes Mellitus, Experimental/*therapy ; *Immunosuppression ; *Islets of Langerhans Transplantation ; Lymphocytes/immunology ; Male ; Mice ; Mice, Inbred BALB C ; Rats ; Transplantation, Heterologous ; Transplantation, Isogeneic
    Print ISSN: 0036-8075
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  • 10
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    Computers, health care, and medical information science (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-17
    Description: The clinical laboratory is examined as a microcosm of the entire health care delivery system. The introduction of computers into the clinical laboratory raises issues that are difficult to resolve by the methods of information science or medical science applied in isolation. The melding of these two disciplines, together with the contributions of other disciplines, has created a new field of study called medical information science. The emergence of this new discipline and some specific problem-solving approaches used in its application in the clinical laboratory are examined.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lincoln, T L -- Korpman, R A -- New York, N.Y. -- Science. 1980 Oct 17;210(4467):257-63.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6999622" target="_blank"〉PubMed〈/a〉
    Keywords: Clinical Laboratory Techniques/*instrumentation ; Costs and Cost Analysis ; *Delivery of Health Care/economics ; Diagnosis, Computer-Assisted/*methods ; Humans ; Information Systems ; Time Factors
    Print ISSN: 0036-8075
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  • 11
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    Phenacetin safety (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Macklin, A W -- Welch, R M -- New York, N.Y. -- Science. 1980 Jan 11;207(4427):129-30, 132.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7350647" target="_blank"〉PubMed〈/a〉
    Keywords: Aminopyrine/adverse effects/toxicity ; Animals ; Humans ; Mice ; Mutagens ; Phenacetin/administration & dosage/*adverse effects/toxicity ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 12
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    Immunoglobulin gene rearrangement in immature B cells (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-09-19
    Description: Two types of immature B cells, namely fetal liver hybridomas and the leukemic cell line 70Z/3, both of which have cytoplasmic mu chains but no light chains, were examined for DNA rearrangements of their light chain and heavy chain immunoglobulin genes. In the fetal liver hybridomas, which were constructed from fetal liver cells and a tumor cell, no light chain gene rearrangement was observed, whereas in the 70Z/3 cell line a kappa light chain rearrangement probably occurred. The results suggest that, although the lack of light chain synthesis can be due to a lack of gene rearrangement, there may also be transcriptional regulation, which may also be important for the expression of light chain immunoglobulins in immature B cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maki, R -- Kearney, J -- Paige, C -- Tonegawa, S -- New York, N.Y. -- Science. 1980 Sep 19;209(4463):1366-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6774416" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes/*immunology ; Genes ; Hybrid Cells/immunology ; Immunoglobulin Constant Regions/genetics ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin Light Chains/*genetics ; Immunoglobulin Variable Region/genetics ; Immunoglobulin kappa-Chains/*genetics ; Immunoglobulin mu-Chains/*genetics ; Leukemia, Experimental/*immunology ; Liver/*embryology ; Mice ; Recombination, Genetic ; Transcription, Genetic
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 13
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    Mapping of heavy chain genes for mouse immunoglobulins M and D (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-09-19
    Description: A single DNA fragment containing both mu and delta immunoglobulin heavy chain genes has been cloned from normal BALB/c mouse liver DNA with a new lambda phage vector Charon 28. The physical distance between the membrane terminal exon of mu and the first domain of delta is 2466 base pairs, with delta on the 3' side of mu. A single transcript could contain a variable region and both mu and delta constant regions. The dual expression of immunoglobulins M and D on spleen B cells may be due to alternate splicing of this transcript.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, C P -- Tucker, P W -- Mushinski, J F -- Blattner, F R -- New York, N.Y. -- Science. 1980 Sep 19;209(4463):1348-53.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6774414" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes/immunology ; Chromosome Deletion ; *Genes ; Immunoglobulin Constant Regions/genetics ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin delta-Chains/*genetics ; Immunoglobulin mu-Chains/*genetics ; Liver/physiology ; Membrane Proteins/genetics ; Mice ; Myeloma Proteins/genetics ; Plasmids ; RNA, Messenger/genetics ; Recombination, Genetic
    Print ISSN: 0036-8075
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  • 14
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    Specific reading disability: differences in contrast sensitivity as a function of spatial frequency (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-01
    Description: Contrast thresholds for sine-wave gratings of spatial frequencies of 2, 4, 12, and 16 cycles per degree were determined for normal and disabled readers at a range of stimulus durations. Normal readers demonstrated monotonically decreasing sensitivity with increasing spatial frequency at exposure durations between 40 and 100 milliseconds. At exposure durations of 150 to 1000 milliseconds, they showed peak sensitivity at 4 cycles per degree. In comparison, disabled readers showed monotonically decreasing sensitivity with increasing spatial frequency at all stimulus durations. The difference in sensitivity pattern across spatial frequencies was greatest at stimulus durations approximately equal to fixation durations during reading.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lovegrove, W J -- Bowling, A -- Badcock, D -- Blackwood, M -- New York, N.Y. -- Science. 1980 Oct;210(4468):439-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7433985" target="_blank"〉PubMed〈/a〉
    Keywords: Afterimage/physiology ; Dyslexia/*physiopathology ; Humans ; Space Perception/physiology ; Time Factors ; Visual Perception/*physiology
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  • 15
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    Elevated cerebrospinal fuid norepinephrine in schizophrenics: confounding effects of treatment drugs (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lipsky, J J -- New York, N.Y. -- Science. 1980 Oct 3;210(4465):97.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6106286" target="_blank"〉PubMed〈/a〉
    Keywords: Antipsychotic Agents/*pharmacology ; Humans ; Norepinephrine/*cerebrospinal fluid ; Research Design ; Schizophrenia/*cerebrospinal fluid/drug therapy ; Time Factors
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  • 16
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    Selective inhibition of glycoprotein and membrane protein of vesicular stomatitis virus from interferon-treated cells (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-01
    Description: A 200-fold inhibition in the titer of infectious vesicular stomatitis virus (VSV) was produced in cultures of Ly cells treated with 30 reference units of interferon per milliliter. Virus particle production, as measured by VSV particle-associated transcriptase, or nucleocapsid protein was inhibited by a maximum of tenfold. The glycoprotein and membrane protein content was reduced in VSV derived from interferon-treated cells. Thus interferon-treated cells may have produced VSV particles with low infectivity, which may be related to the reduced amount of glycoprotein incorporated into such particles. These findings resemble those reported in interferon-treated cells infected with murine leukemia viruses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maheshwari, R K -- Jay, F T -- Friedman, R M -- New York, N.Y. -- Science. 1980 Feb 1;207(4430):540-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6243416" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Defective Viruses/growth & development ; Glycoproteins/*biosynthesis ; Interferons/*pharmacology ; Membrane Proteins/*biosynthesis ; Mice ; RNA, Viral/metabolism ; Vesicular stomatitis Indiana virus/*growth & development ; Viral Proteins/*biosynthesis ; Virus Replication/*drug effects
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  • 17
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    (-)Pentobarbital opens ion channels of long duration in cultured mouse spinal neurons (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-25
    Description: Intracellular recordings from voltage-clamped mouse spinal neurons in tissue culture were used to study the membrane mechanisms underlying inhibitory responses to gamma-aminobutyric acid and the (-) isomer of pentobarbital. Fluctuation analysis suggested that both substances activated ion channels in the membranes. However, the channels activated by pentobarbital remained open five times longer than those activated by gamma-aminobutyric acid.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mathers, D A -- Barker, J L -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):507-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6248961" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Membrane/drug effects/physiology ; Cells, Cultured ; Ion Channels/drug effects/*physiology ; Membrane Potentials/drug effects ; Mice ; Neurons/drug effects/*physiology ; Pentobarbital/*pharmacology ; Spinal Cord/*physiology ; gamma-Aminobutyric Acid/pharmacology
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  • 18
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    Vesicle targeting: timed release and specificity for leukocytes in mice by subcutaneous injection (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-18
    Description: When unilamellar vesicles were administered subcutaneously in mice, the half-time for the destruction of the vesicles varied from 12 to 600 hours, depending on their composition. The vesicles tested consisted of distearoyl phosphatidylcholine, cholesterol, and certain sugar and amino-sugar derivatives of cholesterol. Vesicle with amino-sugar derivatives showed the greatest longevity and became localized with high specificity in aggregates of polymorphonuclear leukocytes. A substantial delay between the time that the vesicles broke open and the time that labels contained in the vesicles were excreted suggests that the vesicles undergo endocytosis before destruction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mauk, M R -- Gamble, R C -- Baldeschwieler, J D -- New York, N.Y. -- Science. 1980 Jan 18;207(4428):309-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7350660" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cholesterol/analogs & derivatives ; Endocytosis ; Liposomes/*therapeutic use ; Lysosomes/metabolism ; Metabolic Clearance Rate ; Mice ; Neutrophils/*metabolism ; Phosphatidylcholines ; Structure-Activity Relationship
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  • 19
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    Mebendazole therapy of parenteral trichinellosis (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-14
    Description: Mebendazole was highly effective against the helminth parasite Trichinella spiralis in mice subjected to a 3-day course of treatment during the invasive and encystment phases of experimental trichinellosis. When treatment began either 2 or 4 weeks after the mice were inoculated with parasites, the number of larvae developing in the host musculature was greatly reduced by twice-daily oral administration of 3.125, 6.25, or 12.5 milligrams of mebendazole per kilogram of body weight.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCracken, R O -- Taylor, D D -- New York, N.Y. -- Science. 1980 Mar 14;207(4436):1220-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7355285" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Oral ; Animals ; Benzimidazoles/*therapeutic use ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Larva ; Male ; Mebendazole/administration & dosage/*therapeutic use ; Mice ; Muscles/parasitology ; Trichinella/drug effects ; Trichinellosis/*drug therapy
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  • 20
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    Insertion of a new gene of viral origin into bone marrow cells of mice (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-05-30
    Description: DNA containing the herpes simplex virus thymidine kinase (HSVtk) gene was used to transform wild-type tk+ mouse L cells to a tk++ status in vitro using methotrexate as a selective agent. HSVtk DNA was also used to transform mouse bone marrow cells in vitro. Transformed marrow cells injected into irradiated and methotrexate-treated recipient mice gave rise to proliferating cells which in some cases dominated the marrow population and which contained HSVtk gene sequences.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mercola, K E -- Stang, H D -- Browne, J -- Salser, W -- Cline, M J -- New York, N.Y. -- Science. 1980 May 30;208(4447):1033-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6246577" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Marrow/*enzymology ; Bone Marrow Transplantation ; DNA, Viral/analysis ; Drug Resistance ; *Genes, Viral ; L Cells (Cell Line) ; Methotrexate/pharmacology ; Mice ; Simplexvirus/enzymology/*genetics ; Species Specificity ; Thymidine Kinase/*genetics ; *Transformation, Genetic
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  • 21
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    J genes for heavy chain immunoglobulins of mouse (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-09-05
    Description: A 15,8-kilobase pair fragment of BALB/c mouse liver DNA, cloned in the Charon 4A lambda phage vector system, was shown to contain the mu heavy chain constant region (CHmu) gene for the mouse immunoglobulin M. In addition, this fragment of DNA contains at least two J genes, used to code for the carboxyl terminal portion of heavy chain variable regions. These genes are located in genomic DNA about eight kilobase pairs to the 5' side of the CHmu gene. The complete nucleotide sequence of a 1120-base pair stretch of DNA that includes the two J genes has been determined.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Newell, N -- Richards, J E -- Tucker, P W -- Blattner, F R -- New York, N.Y. -- Science. 1980 Sep 5;209(4461):1128-32.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6250219" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Binding Sites, Antibody/*genetics ; DNA Restriction Enzymes ; DNA, Recombinant ; Genes ; Genetic Linkage ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin Variable Region/*genetics ; Immunoglobulin mu-Chains/*genetics ; Mice
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  • 22
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    Vitamin D deficiency inhibits pancreatic secretion of insulin (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-08-15
    Description: The effects of a vitamin D deficiency on insulin and glucagon release was determined in the isolated perfused rat pancreas by radioimmunoassay of the secreted proteins. During a 30-minute period of perfusion with glucose and arginine, pancreases from vitamin D-deficient rats exhibited a 48 percent reduction in insulin secretion compared to that for pancreases from vitamin D-deficient rats that had been replenished with vitamin D. Vitamin D status had no effect on pancreatic glucagon secretion. This result, along with the previously demonstrated presence in the pancreas of a vitamin D-dependent calcium-binding protein and cytosol receptor for the hormonal form of vitamin D, 1,25-dihydroxyvitamin D3, indicates an important role for vitamin D in the endocrine functioning of the pancreas.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, A W -- Frankel, J B -- Heldt, A M -- Grodsky, G M -- New York, N.Y. -- Science. 1980 Aug 15;209(4458):823-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6250216" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arginine/pharmacology ; Cholecalciferol/*deficiency ; Glucagon/secretion ; Glucose/pharmacology ; Insulin/*secretion ; Islets of Langerhans/*secretion ; Rats ; Time Factors ; Vitamin D Deficiency/*metabolism
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  • 23
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    Feeding: satiety signal from intestine triggers brain's noradrenergic mechanism (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-08-29
    Description: Noradrenergic neurons in the hypothalamus involved in feeding and satiety are activated by gastrointestinal receptors. In the unrestrained rat, sites were first identified at which norepinephrine injected in the medial hypothalamus caused spontaneous feeding, or in the lateral hypothalamus caused no response. The activity of in vivo norepinephrine at these two sites was characterized by localized push-pull perfusion. When a nutrient was infused directly into the rat's duodenum, the synaptic release of hypothalamic norepinephrine was enhanced at lateral sites insensitive to norepinephrine, but suppressed at medial sites reactive to norepinephrine. Thus, signals from duodenal receptors are conceivably sent to the rat's brain to end feeding by way of noradrenergic inhibitory neurons in the hypothalamus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Myers, R D -- McCaleb, M L -- New York, N.Y. -- Science. 1980 Aug 29;209(4460):1035-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7403866" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Duodenum/innervation/*physiology ; Feeding Behavior/physiology ; Glucose ; Hypothalamus/*physiology ; Norepinephrine/*physiology ; Rats ; Satiation/*physiology ; Satiety Response/*physiology ; Time Factors
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  • 24
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    Gene affecting superoxide dismutase activity linked to the histocompatibility complex in H-2 congenic mice (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-01-04
    Description: The activity of cyanide-sensitive, Cu-Zn superoxide dismutase (SOD) was studied in liver sytosols from H-2 congenic strains of mice. Higher SOD activity was found in livers of mice having H-2b/A.BY, B10, and C3H.SW/haplotypes than in those of H-2a, H-2k and H-2d haplotypes. Segregation studies supported these correlations. In H-2 recombinant strains of mice, the genes influencing the liver SOD activity occur, as ascertained by mapping techniques, at or near the H-2d region of the major histocompatibility complex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Novak, R -- Bosze, Z -- Matkovics, B -- Fachet, J -- New York, N.Y. -- Science. 1980 Jan 4;207(4426):86-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7350646" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Genes ; Genes, Regulator ; Genetic Linkage ; H-2 Antigens/*genetics ; Liver/enzymology ; *Major Histocompatibility Complex ; Mice ; Superoxide Dismutase/*genetics
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  • 25
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    Substance P: does it produce analgesia or hyperalgesia? (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-04-18
    Description: In the hot plate test, substance P given intravenously at doses of 5 x 10-5 and 5 x 10-4 gram per kilogram caused analgesia, while lower doses caused hyperalgesia. The influence of substance P on nociception depended on the individual mouse's sensitivity to pain (control response latency). Analgesia was produced by substance P administered to mice with high sensitivity to thermic stimulation, whereas hyperalgesia occurred in mice whose control latencies were longer than normal. This result is interpreted as an indication that substance P is capable of normalizing responsiveness to pain and could be classified as a regulatory peptide.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Oehme, P -- Hilse, H -- Morgenstern, E -- Gores, E -- New York, N.Y. -- Science. 1980 Apr 18;208(4441):305-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6154313" target="_blank"〉PubMed〈/a〉
    Keywords: Acetates ; Animals ; Dose-Response Relationship, Drug ; Hot Temperature ; Hyperalgesia/*chemically induced ; Hyperesthesia/*chemically induced ; Mice ; Nociceptors/drug effects ; Pain/*physiopathology ; Perception/*drug effects ; Receptors, Drug/physiology ; Substance P/*pharmacology
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    Human monoclonal antibody against Forssman antigen (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-10-31
    Description: Hybrid cells formed between human lymphocytes and mouse myeloma cells produce human immunoglobulin in culture. Stable antibody-producing cell lines can be isolated after multiple cycles of low-density passage, cloning, and continued selection for immunoglobulin production. The origin and characteristics of a hybrid of human and mouse cells is described. This hybrid produces high concentrations (8.3 micrograms per milliliter) of human immunoglobulin M reactive with the terminal disaccharide of the Forssman glycolipid. These findings point to the potential use of human-mouse hybrid cells as a source of human monoclonal antibodies for therapeutic and diagnostic purposes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nowinski, R -- Berglund, C -- Lane, J -- Lostrom, M -- Bernstein, I -- Young, W -- Hakomori, S I -- Hill, L -- Cooney, M -- New York, N.Y. -- Science. 1980 Oct 31;210(4469):537-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7423202" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibodies ; Antibody Formation ; Antibody Specificity ; Cells, Cultured ; Clone Cells/immunology ; *Forssman Antigen ; Humans ; Hybrid Cells/immunology ; Immunoglobulin M/biosynthesis ; Mice
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  • 27
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    alpha-Lactalbumin-casein induction in virgin mouse mammary explants: dose-dependent differential action of cortisol (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-03-21
    Description: The interplay of insulin, cortisol, and prolactin induces synthesis of casein and alpha-lactalbumin in cultured mammary explants from mature virgin mice. A striking difference has been found between the optimal concentrations of cortisol required for maximal induction of the two milk proteins in vitro: 3 x 10(-8) molar for alpha-lactalbumin and 3 x 10(-6) molar for casein. Moreover, 10(-7) to 10(-5) molar cortisol caused progressive inhibition of alpha-lactalbumin accumulation. Such differential actions of cortisol may partly account for the asynchronous synthesis of the two proteins during pregnancy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ono, M -- Oka, T -- New York, N.Y. -- Science. 1980 Mar 21;207(4437):1367-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6986657" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Caseins/*biosynthesis ; Dose-Response Relationship, Drug ; Drug Interactions ; Female ; Hydrocortisone/*pharmacology ; Insulin/pharmacology ; Lactalbumin/*biosynthesis ; Mammary Glands, Animal/drug effects/*metabolism ; Mice ; Organ Culture Techniques ; Pregnancy ; Prolactin/pharmacology
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  • 28
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    Properties of a normal mouse cell DNA sequence (sarc) homologous to the src sequence of Moloney sarcoma virus (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-03-14
    Description: A 15.0-kilobase (kb) Eco RI DNA fragment from normal mouse Balb/c genomic DNA that contains sequences (sarc) homologous to the acquired cell sequences (src) of Moloney sarcoma virus (MSV) has been cloned in phage lambda. The sarc region (1.2 to 1.3 kb) of the 15.0-kb cell fragment is indistinguishable from the src region of two isolates of MSV as judged by heteroduplex and restriction endonuclease analyses. The cellular sequences flanking sarc show no homology to other MSV sequences. Whereas cloned subgenomic portions of MSV that contain src transformed NIH-3T3 cells in vitro, the cloned sarc fragment is inactive.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Oskarsson, M -- McClements, W L -- Blair, D G -- Maizel, J V -- Vande Woude, G F -- New York, N.Y. -- Science. 1980 Mar 14;207(4436):1222-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6243788" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Chromosome Mapping ; DNA Restriction Enzymes ; *Genes ; *Genes, Viral ; Mice ; Mice, Inbred BALB C/*genetics ; Moloney murine leukemia virus/*genetics ; Nucleic Acid Hybridization
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  • 29
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    Cytosolic and microsomal epoxide hydrolases: differential properties in mammalian liver (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-03-28
    Description: The epoxide hydrolase activities of the 100,000 g pellet (microsomal) and 100,00 g soluble (cystosolic) fractions of mouse, rat, and guinea pig liver were measured with three closely related compounds used as substrates. Differences between the species in the distribution of the cytosolic and microsomal hydrolases and in their substrate specificities and pH optima demonstrate why epoxide hydrolase activity in the cytosolic fraction was not detected earlier in spie of intensive work on the microsomal epoxide hydrolase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ota, K -- Hammock, B D -- New York, N.Y. -- Science. 1980 Mar 28;207(4438):1479-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7361100" target="_blank"〉PubMed〈/a〉
    Keywords: Allyl Compounds ; Animals ; Benzene ; Cytosol/enzymology ; Epoxide Hydrolases/*metabolism ; Guinea Pigs ; Hydrogen-Ion Concentration ; Liver/*enzymology/ultrastructure ; Mice ; Microsomes, Liver/enzymology ; Rats ; Styrenes ; Substrate Specificity
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  • 30
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    Genes for growth hormone, chorionic somatommammotropin, and growth hormones-like gene on chromosome 17 in humans (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-07-11
    Description: The human genes for growth hormone (GH), chorionic somatomammotropin (CSH), and a third growth hormone-like gene (GHL) have been located on chromosome 17 in humans. DNA fragments of 2.6, 2.8, and 9.5 kilobase pairs containing GH, CSH, and GHL, respectively, were identified in human genomic DNA, and a 7.5-kilobase DNA fragment related to growth hormone DNA sequences was found in mouse cells. In somatic hybrids of human and mouse cells containing reduced numbers of human chromosomes, but a normal complement of mouse chromosomes, the mouse, 7.5-kolobase DNA fragment was always present, whereas the 2.6-, 2.8-, and 9.5-kilobase human fragments were present only when human chromosome 17 was also present.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Owerbach, D -- Rutter, W J -- Martial, J A -- Baxter, J D -- Shows, T B -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):289-92.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7384802" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cell Line ; *Chromosomes, Human, 16-18 ; *DNA/metabolism ; *Genes ; Growth Hormone/*biosynthesis ; Humans ; Hybrid Cells/metabolism ; Mice ; Placental Lactogen/*biosynthesis ; Translocation, Genetic
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  • 31
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    Flavor-illness aversions: the peculiar roles of odor and taste in memory for poison (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-05-16
    Description: When either taste or odor alone was followed by poison, rats acquired a strong aversion for the taste but not for odor, especially if poison was delayed. When odor-taste combinations were poisoned, however, odor aversions were potentiated, as if odor could gain the enduring memorial property of taste by associative contiguity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Palmerino, C C -- Rusiniak, K W -- Garcia, J -- New York, N.Y. -- Science. 1980 May 16;208(4445):753-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7367891" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Avoidance Learning/*physiology ; Conditioning (Psychology)/physiology ; Lithium/poisoning ; Male ; Rats ; Smell/*physiology ; Taste/*physiology ; Time Factors
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  • 32
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    Opiate analgesia: evidence for mediation by a subpopulation of opiate receptors (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-05-02
    Description: Naloxazone, a hydrazone derivative of the opiate antagonist naloxone, has a high affinity for opiate receptor binding sites. Naloxazone injections reduce opiate receptor binding to extensively washed mouse brain membranes for more than 24 hours, suggesting that the effect is irreversible. High-affinity binding sites are abolished by this treatment, whereas low-affinity sites are unaffected. Naloxazone treatment blocks the analgesic effects of morphine for at least 24 hours but does not prevent death from high doses of morphine. Thus analgesic but nonlethal opiate effects may be mediated by the high-affinity subpopulation of opiate receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pasternak, G W -- Childers, S R -- Snyder, S H -- New York, N.Y. -- Science. 1980 May 2;208(4443):514-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6245448" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding Sites/drug effects ; Brain/metabolism ; Mice ; Morphine/pharmacology/toxicity ; Naloxone/adverse effects/*analogs & derivatives/pharmacology ; Receptors, Opioid/classification/*drug effects/physiology
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  • 33
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    Binocularity in the cat visual cortex is reduced by sectioning the corpus callosum (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-03-07
    Description: In the normal cat, most cells in area 17 can be binocularly driven. Sectioning the corpus callosum results in a significant reduction in binocularly driven cells. Normal binocular vision is thus dependent on the corpus callosum.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Payne, B R -- Elberger, A J -- Berman, N -- Murphy, E H -- New York, N.Y. -- Science. 1980 Mar 7;207(4435):1097-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7355278" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Corpus Callosum/*physiology/surgery ; Functional Laterality ; Time Factors ; Visual Fields ; Visual Pathways/physiology ; Visual Perception/*physiology
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    Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-03
    Description: Antidepressants compete at several neurotransmitter receptor binding site, but drug affinities do not correlate with clinical efficacy. Long-term, but not short-term, antidepressant treatment decreases the numbers of both serotonin and beta-adrenergic receptors. The decrease in the number of receptor sites is most marked for [3H]spiroperidol-labeled serotonin receptors and is characteristic for antidepressants of several classes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peroutka, S J -- Snyder, S H -- 5T32GM0309/GM/NIGMS NIH HHS/ -- DA00266/DA/NIDA NIH HHS/ -- MH18501/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1980 Oct 3;210(4465):88-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6251550" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antidepressive Agents/administration & dosage/metabolism/*pharmacology ; Frontal Lobe/drug effects ; Male ; Rats ; Receptors, Adrenergic, alpha/metabolism ; Receptors, Adrenergic, beta/drug effects/metabolism ; Receptors, Dopamine/metabolism ; Receptors, Histamine H1/metabolism ; Receptors, Muscarinic/metabolism ; Receptors, Serotonin/*drug effects/metabolism ; Spiperone/metabolism ; Time Factors
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    Estrogen and the growth of breast cancer: new evidence suggests indirect action (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-08
    Description: The growth of the MCF-7 human breast cancer cell line is unresponsive to the presence of estrogen in culture media. Paradoxically, in nude mice, growth of these cells and formation of solid tumors are dependent on estrogen. Tumors fail to develop in ovariectomized mice, but do develop in intact mice and in ovariectomized mice given estrogen. Primary cultures derived from MCF-7 tumors revert to unresponsiveness to estrogen. However, when these cultures are again transplanted into nude mice, estrogen is required for tumor formation. The continuous culture, the solid tumor, and the primary cultures therefrom have similar estrogen-binding capacities and affinities. These results indicate that mammary carcinoma cell growth in vivo is subject to inhibition that can be overcome by estrogen.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shafie, S M -- New York, N.Y. -- Science. 1980 Aug 8;209(4457):701-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6994231" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Breast Neoplasms/metabolism/*physiopathology ; Castration ; Cell Division/drug effects ; Cell Line ; Cytosol/metabolism ; Estradiol/metabolism/*pharmacology ; Female ; Humans ; Insulin/pharmacology ; Mice ; Mice, Nude ; Neoplasm Transplantation ; Receptors, Estrogen/metabolism ; Transplantation, Heterologous
    Print ISSN: 0036-8075
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    Correction of enzyme deficiency in mice by allogeneic bone marrow transplantation with total lymphoid irradiation (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-12-05
    Description: Enzyme deficiency was corrected in mice after allogeneic bone marrow transplantation with occurrence of graft versus host disease. beta-Glucuronidase-deficient C3H/HeJ mice were treated with total lymphoid irradiation. Normal bone marrow cells (30 X 10(6)) from BALB/c to C3H/HeJ chimeras (〉90 percent circulating donor-type cells) without graft versus host disease. beta-Glucuronidase activity increases to normal levels in all chimeras as measured in the liver and in the plasma. Activity was maintained throughout an observation period of 7 months.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slavin, S -- Yatziv, S -- A1 15387/PHS HHS/ -- New York, N.Y. -- Science. 1980 Dec 5;210(4474):1150-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7003711" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Bone Marrow Transplantation ; Glucuronidase/blood/*deficiency ; Liver/enzymology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C3H ; Radiation Chimera ; Transplantation, Homologous
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    Food dyes impair performance of hyperactive children on a laboratory learning test (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-03-28
    Description: Forty children were given a diet free of artificial food dyes and other additives for 5 days. Twenty of the children had been classified as hyperactive by scores on the Conners Rating Scale and were reported to have favorable responses to stimulant medication. A diagnosis of hyperactivity had been rejected in the other 20 children. Oral challenges with large doses (100 or 150 milligrams) of a blend of FD & C approved food dyes or placebo were administered on days 4 and 5 of the experiment. The performance of the hyperactive children on paired-associate learning tests on the day they received the dye blend was impaired relative to their performance after they received the placebo, but the performance of the nonhyperactive group was not affected by the challenge with the food dye blend.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Swanson, J M -- Kinsbourne, M -- New York, N.Y. -- Science. 1980 Mar 28;207(4438):1485-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7361102" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; Dose-Response Relationship, Drug ; Female ; Food Coloring Agents/*pharmacology ; Humans ; Hyperkinesis/*physiopathology ; Learning/*drug effects ; Male ; Time Factors
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    Neurobiology of amnesia (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Squire, L R -- Davis, H P -- Spanis, C W -- New York, N.Y. -- Science. 1980 Aug 15;209(4458):836-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7190729" target="_blank"〉PubMed〈/a〉
    Keywords: Amnesia/*physiopathology ; Amnesia, Retrograde/*physiopathology ; Animals ; Brain Chemistry ; Catecholamines/metabolism ; Cycloheximide/pharmacology ; Humans ; Memory/drug effects ; Mice ; Nerve Tissue Proteins/biosynthesis ; Phenoxybenzamine/pharmacology
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  • 39
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    Calcium transients during excitation-contraction coupling in mammalian heart: aequorin signals of canine Purkinje fibers (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-03-07
    Description: Aequorin signals in mammalian heart muscle cells reveal the existence of two temporally distinct processes that increase cytoplasmic calcium ions after membrane excitation. The differential dependence of these processes on the pattern of stimulation suggests that the first process is, or is closely related to, calcium entry through the surface membrane and that the second is calcium release from intracellular storage sites.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wier, W G -- New York, N.Y. -- Science. 1980 Mar 7;207(4435):1085-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7355274" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Aequorin/metabolism ; Animals ; Calcium/*metabolism ; Cell Compartmentation ; Dogs ; Heart Conduction System/*metabolism ; In Vitro Techniques ; Ion Channels/metabolism ; Membrane Potentials ; *Myocardial Contraction ; Purkinje Fibers/*metabolism ; Time Factors
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    Glucan-induced modification of murine viral hepatitis (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-04-04
    Description: Glucan, a macrophage stimulant, was evaluated for its ability to alter survival and phagocytic dysfunction in mice challenged with mouse hepatitis virus strain MHV-A59. Administration of glucan before the mice were challenged with the virus significantly prolonged median survival time but did not modify overall mortality compared with control mice given dextrose. Maximal effectiveness was achieved when glucan was administered both before and after the viral challenge. In contrast to the marked hepatic parenchymal cell necrosis observed in the control mice, glucan-treated mice exhibited reduced pathology. Intraperitoneal administration of MHV-A59 resulted in a significant depression of phagocytic activity compared with controls that were not exposed to the virus. The enhancement in phagocytic function in glucan-treated control mice was unaltered in virus-challenged, glucan-treated mice. Thus glucan is capable of increasing survival, inhibiting hepatic necrosis, and maintaining an activated state of phagocytic activity in mice challenged with MHV-A59. Macrophage stimulants may have a significant role in the modification of virally induced hepatic lesions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Williams, D L -- Di Luzio, N R -- New York, N.Y. -- Science. 1980 Apr 4;208(4439):67-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7361108" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Glucans/*pharmacology/therapeutic use ; Hepatitis, Viral, Animal/drug therapy/*immunology/mortality ; Liver/pathology ; Macrophages/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Phagocytosis/*drug effects
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    Multiple daily amphetamine administration: behavioral and neurochemical alterations (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-02-15
    Description: In rats, multiple daily amphetamine injections (2.5 milligrams per kilogram of body weight, injected subcutaneously every 4 hours for 5 days) resulted in a progressive augmentation in response, characterized by a more rapid onset and an increased magnitude of stereotypy. By contrast, offset times of both the stereotypy and the poststereotypy hyperactivity periods were markedly shortened. When the animals were retested with the same dose of amphetamine 8 days after the long-term treatment was discontinued, the time of offset of the stereotypy and hyperactivity phases had recovered to values found with short-term amphetamine treatment, whereas the more rapid onset of stereotypy persisted. Brain monoamine and amphetamine concentrations and tyrosine hydroxylase activity were determined in comparably treated rats at times corresponding to the behavioral observations. The behavioral data indicate that enhanced responsiveness to amphetamine following its repeated administration may contribute to the development of amphetamine psychosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Segal, D S -- Weinberger, S B -- Cahill, J -- McCunney, S J -- New York, N.Y. -- Science. 1980 Feb 15;207(4433):905-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7188815" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior/*drug effects ; Behavior, Animal/*drug effects ; Brain/metabolism ; Brain Chemistry/drug effects ; Dextroamphetamine/administration & dosage/*pharmacology ; Dopamine/metabolism ; Dose-Response Relationship, Drug ; Humans ; Male ; Motor Activity/drug effects ; Norepinephrine/metabolism ; Rats ; Serotonin/metabolism ; Stereotyped Behavior/*drug effects ; Time Factors
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    Rate of acoustic change may underlie hemispheric specialization for speech perception (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-03-21
    Description: Phonemically similar syllables, differing only by temporal acoustic cues, were presented dichotically to investigate temporal processing mechanisms in hemispheric specialization for speech. Reducing the rate of acoustic change within syllables while keeping their phonemic characteristics constant significantly decreased the characteristic asymmetry in processing speech.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwartz, J -- Tallal, P -- New York, N.Y. -- Science. 1980 Mar 21;207(4437):1380-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7355297" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Auditory Pathways/physiology ; Auditory Perception/*physiology ; Brain/*physiology ; Female ; *Functional Laterality ; Humans ; Linguistics ; Male ; Speech Perception/*physiology ; Time Factors
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    Latency of herpes simplex virus in absence of neutralizing antibody: model for reactivation (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-11-28
    Description: Mice inoculated with herpes simplex virus (type 1) by the lip or corneal route and then passively immunized with rabbit antibody to herpes simplex virus developed a latent infection in the trigeminal ganglia within 96 hours. Neutralizing antibody to herpes simplex virus was cleared from the circulation and could not be detected in most of these mice after 2 months. Examination of ganglia from the antibody-negative mice revealed latent virus in over 90 percent of the animals, indicating that serum neutralizing antibody is not necessary to maintain the latent state. When the lips or corneas of these mice were traumatized, viral reactivation occurred in up to 90 percent of the mice, as demonstrated by the appearance of neutralizing antibody. This study provides a model for identifying factors that trigger viral reactivation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sekizawa, T -- Openshaw, H -- Wohlenberg, C -- Notkins, A L -- New York, N.Y. -- Science. 1980 Nov 28;210(4473):1026-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6254149" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Viral/*metabolism ; Antigens, Viral/analysis ; Disease Models, Animal ; Ganglia/microbiology ; Herpes Simplex/*immunology ; Immune Tolerance ; Immunization, Passive ; Mice ; Simplexvirus/*growth & development/immunology ; *Virus Activation
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    Hemoglobin switching: a cellular model (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-02-08
    Description: Regulation of hemoglobin synthesis depends in part on the population of cells available for erythroid differentiation. Mouse erythroleukemia cells were cloned, and the clones were induced with dimethyl sulfoxide to test the relative induction of beta minor and beta major synthesis. Cells of line 745 produced approximately 35 percent beta minor after induction, and 39 clones of line 745 produced from 23 to 61 percent beta minor. Further subcloning of the clone that produced 61 percent beta minor led to three subclones, all of which produced more than 90 percent beta minor. Thus one kind of hemoglobin regulation occurs at the cellular level.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alter, B P -- Goff, S C -- New York, N.Y. -- Science. 1980 Feb 8;207(4431):647-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6928071" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; Cell Line ; Clone Cells/metabolism ; Dimethyl Sulfoxide/pharmacology ; Globins/*biosynthesis/genetics ; Leukemia, Erythroblastic, Acute/metabolism ; Mice
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    Polyamine metabolism: a potential therapeutic target in trypanosomes (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-17
    Description: alpha-Difluoromethylornithine (RMI 71,782), a specific irreversible inhibitor of the first step in polyamine biosynthesis, that is, the formation of putrescine from ornithine by ornithine decarboxylase, cures mice infected with a virulent, rodent-passaged strain of Trypanosoma brucei brucei. This parasite is closely related to the trypanosomes that cause human sleeping sickness. The drug, which is remarkably nontoxic, was effective when administered in drinking water or by intubation. The ability of the compound to inhibit ornithine decarboxylase in vitro was demonstrated by the reduced amounts of putrescine synthesized from tritiated ornithine in Trypanosoma brucei suspensions. These observations direct attention to polyamine metabolism as a target for chemotherapy of parasitic diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bacchi, C J -- Nathan, H C -- Hutner, S H -- McCann, P P -- Sjoerdsma, A -- AI 13801/AI/NIAID NIH HHS/ -- AI 13852/AI/NIAID NIH HHS/ -- FR-05596/PHS HHS/ -- New York, N.Y. -- Science. 1980 Oct 17;210(4467):332-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6775372" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Eflornithine ; Mice ; Ornithine/analogs & derivatives/metabolism/pharmacology ; Ornithine Decarboxylase Inhibitors ; Polyamines/*metabolism ; *Trypanocidal Agents ; Trypanosoma brucei brucei/drug effects/metabolism ; Trypanosomiasis, African/*drug therapy
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  • 46
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    Picrotoxin convulsions involve synaptic and nonsynaptic mechanisms on cultured mouse spinal neurons (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-05-30
    Description: The cellular mechanisms underlying picrotoxin-induced convulsive activity were studied by using mouse spinal neurons growing in tissue culture. Picrotoxin-induced convulsive activity in most but not all of the cells studied. The activity could be inverted by polarizing to positive potentials and eliminated either by decreasing the ratio of calcium to magnesium or by applying tetrodotoxin. When applied locally to individual cells, picrotoxin lowered spike threshold and induced spontaneous firing in some but not all cells tested. The results suggest that picrotoxin-induced convulsive activity involves rapidly summating synaptic activity which may be evoked by high-frequency repetitive firing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barker, J L -- MacDonald, J F -- New York, N.Y. -- Science. 1980 May 30;208(4447):1054-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7375918" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Animals ; Calcium/pharmacology ; Cells, Cultured ; Magnesium/pharmacology ; Membrane Potentials/drug effects ; Mice ; Picrotoxin/*pharmacology ; Seizures/*chemically induced ; Spinal Cord/*drug effects/physiology ; Synapses/*drug effects
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    Age-related changes in passive avoidance retention: modulation with dietary choline (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bartus, R T -- Dean, R L -- Goas, J A -- Lippa, A S -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):301-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7384805" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Oral ; Aging ; Animals ; Avoidance Learning/*drug effects ; Choline/administration & dosage/*pharmacology ; Mice ; Mice, Inbred Strains ; Time Factors
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  • 48
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    Phase-sensitive midbrain neurons in Eigenmannia: neural correlates of the jamming avoidance response (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-08-15
    Description: Neurons in the torus semicircularis of the weakly electric fish Eigenmannia encode phase differences between sinusoidal electrical stimuli received in different body regions. These fish normally experience time-varying phase differences when the electric organ discharge fields of two or more individuals overlap. These phase differences supply information necessary for the animal's jamming avoidance behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bastian, J -- Heiligenberg, W -- New York, N.Y. -- Science. 1980 Aug 15;209(4458):828-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7403849" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/physiology ; Electric Organ/*physiology ; Escape Reaction/physiology ; Fishes/*physiology ; Mesencephalon/cytology/physiology ; Orientation/physiology ; Periodicity ; Sensory Receptor Cells/physiology ; Time Factors
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  • 49
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    Mouse leukemia: therapy with monoclonal antibodies against a thymus differentiation antigen (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-01-04
    Description: Monoclonal antibodies against a thymus cell differentiation antigen (Thy-1.1) were effective in the therapy of a transplanted mouse leukemia. Passive immunization resulted in high titers of cytotoxic antibody in the serum of treated mice and the suppression of metastatic tumor cells. The tumor-suppressive effects of the monoclonal antibodies were amplified by the administration of exogenous complement. This combined antibody and complement therapy resulted in the cure of leukemia in a significant proportion of the treated animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bernstein, I D -- Tam, M R -- Nowinski, R C -- New York, N.Y. -- Science. 1980 Jan 4;207(4426):68-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6965328" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibody Specificity ; Antigens, Surface ; Antilymphocyte Serum/*therapeutic use ; Cell Differentiation ; Clone Cells/immunology ; Cytotoxicity, Immunologic ; Immunotherapy ; Leukemia, Experimental/surgery/*therapy ; Mice ; Mice, Inbred Strains ; Neoplasm Metastasis ; T-Lymphocytes/*immunology
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    Adrenocorticotropic hormone may be transported directly from the pituitary to the brain (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-31
    Description: Experiments were designed to test the hypothesis that pituitary hormones may be delivered directly to the brain. Concentrations of adrenocorticotropic hormone (ACTH) in the plasma were determined in blood samles obtained simultaneously from the carotid artery, the sagittal sinus, and the jugular vein of three awake sheep. Seizures were induced electrically to stimulate ACTH secretion, and at precise intervals thereafter several simultaneous comparisons were made in each animal. In many of the post-seizure comparisons, the ACTH plasma concentrations within the sagital sinus exceeded those within the carotid artery as well as those within the jugular vein, indicating that this hormone was released from the pituitary and carried directly through capillary beds of brain to the venous blood within the sagittal sinus. The experiment was repeated in one hypophysectomized sheep and, in this animal, ACTH concentration in the plasma was reduced, but that in the sagittal sinus still was elevated after the seizure, an indication that some ACTH (or ACTH-like material) was released from the brain itself.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bergland, R -- Blume, H -- Hamilton, A -- Monica, P -- Paterson, R -- New York, N.Y. -- Science. 1980 Oct 31;210(4469):541-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6252607" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/*blood ; Animals ; Blood-Brain Barrier ; Brain/*blood supply ; Carotid Arteries ; Epilepsy, Tonic-Clonic/blood ; Female ; Hypophysectomy ; Jugular Veins ; Male ; Sheep ; Time Factors
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    Suckling (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-03
    Description: Suckling is the only behavior that is common among mammals. In newborn albino rats it is originally elicited by amniotic fluid deposited by the mother during parturition. Subsequent suckling is stimulated by saliva deposited on the nipples by the infant rats. Internal controls over the volume of milk suckled do not appear until infant rats are about 2 weeks of age at which time gastric distension, milk, systemic dehydration, and intestinal hormone cholecystokinin suppress milk intake derived through suckling. The development of controls over suckling appetite appears to parallel that of consummatory control. Until about 2 weeks of age infant rats choose to suckle a nonlactating nipple with the same frequency as a lactating nipple. Thereafter, the lactating nipple is unanimously chosen. These studies suggest differences and commonalities in the suckling behavior of laboratory rats and other mammals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blass, E M -- Teicher, M H -- AM-18560/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1980 Oct 3;210(4465):15-22.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6997992" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Population Groups/*physiology ; Animals ; Animals, Suckling/*physiology ; Cholecystokinin/physiology ; Dehydration ; Feeding Behavior/physiology ; Female ; Food Deprivation ; Humans ; Instinct ; Lactation ; Lithium/pharmacology ; Maternal Behavior ; Pheromones ; Pregnancy ; Rats ; Saliva ; Sucking Behavior/drug effects/*physiology ; Time Factors
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    Limitations of metabolic activation systems used with in vitro tests for carcinogens (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-25
    Description: Important differences between the metabolic activation of 7,12-dimethylbenz[a]anthracene in intact cellular systems and in liver homogenates suggest that the use of homogenates in conjunction with short-term assays for carcinogens could yield misleading results.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bigger, C A -- Tomaszewski, J E -- Dipple, A -- Lake, R S -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):503-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6771871" target="_blank"〉PubMed〈/a〉
    Keywords: 9,10-Dimethyl-1,2-benzanthracene/*metabolism ; Animals ; Benz(a)Anthracenes/*metabolism ; Carcinogens/*metabolism ; Cells, Cultured ; DNA/metabolism ; Deoxyribonucleosides ; Drug Evaluation, Preclinical/methods ; Humans ; Liver/*metabolism ; Mice ; Microsomes, Liver/metabolism ; Rats ; Skin/metabolism
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    Electrophoretic injection of a fluorescent dye into giant mitochondria and mitoplasts (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-09-12
    Description: Studies of the electrical properties of giant mitochondria and mitoplasts with microelectrodes have indicated that there are no significant metabolically dependent membrane potentials. The internal location of the microelectrode has been confirmed by electrophoretically microinjecting the water-soluble dye Lucifer yellow CH into giant mitochondria or mitoplasts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bowman, C -- Tedeschi, H -- New York, N.Y. -- Science. 1980 Sep 12;209(4462):1251-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7403882" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Electrophoresis ; Fluorescent Dyes/*administration & dosage ; Membrane Potentials ; Mice ; Microelectrodes ; Mitochondria, Liver/*physiology/ultrastructure
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    Histamine-mediated delayed permeability response after scald burn inhibited by cimetidine or cold-water treatment (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-15
    Description: Scald injury to one ear of the hairless mouse induced significant (P 〈 .05) delayed edema formation in remote, uninjured skin. This remote edema formation was completely inhibited by immediate cold-water treatment of the scalded ear. Cold-water treatment significantly reduced histamine loss from the scalded ear, and the edema-inhibiting effect of the treatment could be mimicked by treating the animal prior to injury with the H2-histamine receptor antagonist cimetidine or a drug that causes histamine depletion. These observations suggest (i) that a histamine-mediated, delayed permeability response occurs after thermal injury that causes remote edema formation and (ii) that one mechanism of remote edema inhibition by cold-water treatment is the prevention of histamine release from thermally injured tissues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boykin, J V Jr -- Eriksson, E -- Sholley, M M -- Pittman, R N -- New York, N.Y. -- Science. 1980 Aug 15;209(4458):815-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6157189" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Burns/complications/physiopathology/*therapy ; Cell Membrane Permeability ; Cimetidine/*pharmacology ; *Cold Temperature ; Edema/etiology/physiopathology ; Guanidines/*pharmacology ; Histamine Release/*drug effects ; Indomethacin/pharmacology ; Male ; Mice ; Receptors, Histamine H2/physiology
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    Inhibition of cell motility by interferon (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-05-02
    Description: Interferon derived from human leukocytes, human fibroblasts, and mouse fibroblasts was found to inhibit the motility of cultured cells. It inhibits the tumor-induced motility of capillary endothelial cells as well as the spontaneous migration of other cell types. The ability of a given preparation of interferon to inhibit the motility of a given cell type is proportional to its antiviral activity in that particular cell type. Antiserum to human leukocyte interferon neutralizes both the motility-inhibitory activity and the antiviral activity of this preparation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brouty-Boye, D -- Zetter, B R -- New York, N.Y. -- Science. 1980 May 2;208(4443):516-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6154315" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antineoplastic Agents ; Antiviral Agents ; Capillaries/cytology ; Cattle ; *Cell Movement ; Cells, Cultured/physiology ; Endothelium/cytology ; Fibroblasts ; Humans ; Interferons/*pharmacology ; Leukocytes/physiology ; Mice ; Neoplasms/pathology
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    gamma-Glutamyl transpeptidase in isolated brain endothelial cells: induction by glial cells in vitro (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-08
    Description: The endothelia of microvessels isolated from mouse brain by mechanical means are rich in gamma-glutamyl transpeptidase; however, the enzyme often disappears when the cells migrate or proliferate from the microvessel isolates. In an endothelial cell line derived from similar isolates and negative for gamma-glutamyl transpeptidase, the enzyme could be induced in the endothelial cells when they were cocultured with glial cells. Thus there may be a requirement for continuous induction of gamma-glutamyl transpeptidase in brain microvessels by adjacent glial cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉DeBault, L E -- Cancilla, P A -- New York, N.Y. -- Science. 1980 Feb 8;207(4431):653-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6101511" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*blood supply ; Capillaries/*enzymology ; Cells, Cultured ; Endothelium/enzymology ; Enzyme Induction ; Glioma/physiopathology ; Mice ; Neuroglia/*physiology ; Rats ; gamma-Glutamyltransferase/*biosynthesis
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    Single-shot channel activation accounts for duration of inhibitory postsynaptic potentials in a central neuron (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-05-09
    Description: In the goldfish Mauthner cell, inhibitory postsynaptic currents evoked by intracellular stimulation of presynaptic neurons decay exponentially, with a mean time constant of 6.65 milliseconds. Analysis of membrane conductance fluctuations induced by iontophoresis of glycine and gamma-aminobutyric acid indicates a mean inhibitory channel lifetime of 7.15 milliseconds. The results thus suggest that the relaxation kinetics of activated inhibitory channels are rate-limiting during decay of the inhibitory postsynaptic current.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Faber, D S -- Korn, H -- New York, N.Y. -- Science. 1980 May 9;208(4444):612-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6245449" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cerebellum/cytology ; Chlorides/physiology ; Electric Conductivity ; Glycine/pharmacology ; Goldfish ; Ion Channels/*physiology ; Membrane Potentials/*drug effects ; *Neural Inhibition ; Neurons/*physiology ; Pons/cytology ; Time Factors ; gamma-Aminobutyric Acid/pharmacology
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    Epidermal growth factor is a major growth-promoting agent in human milk (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-10
    Description: Human milk stimulates DNA synthesis in cell cultures in which growth has been arrested. The mitogenic activity of milk is neutralized by the addition of antibody to human epidermal growth factor. The results identify epidermal growth factor as a major growth-promoting agent in breast milk.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carpenter, G -- CA24071/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1980 Oct 10;210(4466):198-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6968093" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division/drug effects ; Cells, Cultured ; DNA/biosynthesis ; Epidermal Growth Factor/analysis/*pharmacology ; Female ; Humans ; Mice ; Milk, Human/analysis/*physiology ; Mitogens ; Peptides/*pharmacology
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    Fasting associated with decrease in hypothalamic beta-endorphin (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-12-12
    Description: In rats that were fasted for 2 to 3 days there was a decline in hypothalamic, but not pituitary, beta-endorphin. There was no change in pituitary or hypothalamic adrenocorticotropin content as a result of fasting. Endogenous opiates may be involved in physiological adaptation to fasting.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gambert, S R -- Garthwaite, T L -- Pontzer, C H -- Hagen, T C -- New York, N.Y. -- Science. 1980 Dec 12;210(4475):1271-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6254156" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/metabolism ; Animals ; Endorphins/*metabolism ; *Fasting ; Hypothalamus/*metabolism ; Male ; Pituitary Gland/metabolism ; Rats ; Time Factors
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    Endorphin-mediated increases in pain threshold during pregnancy (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-10
    Description: Maternal pain thresholds in rats were determined during various stages of pregnancy and parturition by measuring the intensity of electric shock that elicited reflexive jumping. There was a gradual rise in the pain threshold between 16 and 4 days prior to parturition and a more abrupt rise 1 to 2 days before that event. This increase was abolished by long-term administration of the narcotic antagonist naltrexone. The endorphin system is thus an important component of intrinsic mechanisms that modulate responsiveness to aversive stimuli. The data also demonstrate the activation during pregnancy of an endorphin system that is apparently quiescent in nonpregnant female rats treated the same way.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gintzler, A R -- NIMH GRANT DA01771/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1980 Oct 10;210(4466):193-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7414330" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Drug ; Endorphins/antagonists & inhibitors/*physiology ; Female ; Naltrexone/pharmacology ; Pain/*physiopathology ; Pregnancy ; *Pregnancy, Animal ; Rats ; Time Factors
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    Classical conditioning: induction of luteinizing hormone and testosterone secretion in anticipation of sexual activity (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-11-28
    Description: A classical conditioning paradigm was used to demonstrate that male rats can learn to secrete luteinizing hormone and testosterone in anticipation of sexual activity. Sexually naive males were exposed to a neutral stimulus and then to a sexually receptive female once daily. After exposure to the paired stimuli for 14 trials, the neutral stimulus was as effective as the female in triggering luteinizing hormone and testosterone secretion. These findings provide two novel perspectives on the control of reproductive hormone secretion in male rats: (i) environmental cues, which males learn to associate with sexual activity, induce the secretion of hormones that regulate pituitary-testis function, and (ii) classical conditioning may be used as a noninvasive method to evoke functional alterations in the secretion of luteinizing hormone and presumably the neuroendocrine pathways that mediate its release.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Graham, J M -- Desjardins, C -- HD-13470/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1980 Nov 28;210(4473):1039-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7434016" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arousal/physiology ; Conditioning, Classical/*physiology ; Humans ; Luteinizing Hormone/*secretion ; Male ; Pituitary Gland, Anterior/secretion ; Rats ; Sexual Behavior, Animal/*physiology ; Testis/secretion ; Testosterone/*secretion ; Time Factors
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    Parathyroid hormone: a coronary artery vasodilator (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-07
    Description: Injection of synthetic bovine parathyroid hormone (the amino terminal peptide containing the first 34 amino acids) to the coronary circulation of the dog resulted in a marked coronary vasodilation. The vasodilatory response was dose-dependent and amounted to a 161 percent increase over the resting flow rate at a concentration of 1.0 unit per kilogram.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crass, M F 3rd -- Pang, P K -- New York, N.Y. -- Science. 1980 Mar 7;207(4435):1087-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7355275" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Coronary Circulation/*drug effects ; Dogs ; Hormones/pharmacology ; Myocardial Contraction/drug effects ; Myocardium/metabolism ; Oxygen Consumption/drug effects ; Parathyroid Hormone/*pharmacology ; Time Factors ; Vascular Resistance/drug effects ; *Vasodilator Agents
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    Postsynaptic transmission block can cause terminal sprouting of a motor nerve (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-02-08
    Description: Sprouting of mouse soleus motor nerve terminals can be evoked by daily intramuscular injections of purified alpha-bungarotoxin. This finding supports the hypothesis that an important stimulus to terminal sprouting in partial denervation and presynaptic nerve blockade is a product of inactive muscle fibers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holland, R L -- Brown, M C -- New York, N.Y. -- Science. 1980 Feb 8;207(4431):649-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6243417" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Botulinum Toxins/pharmacology ; Bungarotoxins/*pharmacology ; Female ; Mice ; Motor Endplate/drug effects ; Motor Neurons/*growth & development ; Muscles/innervation ; Neuromuscular Junction/*physiology ; Receptors, Cholinergic/drug effects ; Synaptic Transmission/*drug effects
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    Swelling of nerve fibers associated with action potentials (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-17
    Description: Swelling of nerve fibers during the action potential was demonstrated by three different methods. Generation of a propagated nerve impulse in a crab nerve produced an outward movement of 50 to 100 angstroms of the nerve surfce and a rise in swelling pressure on the order of 5 dynes per square centimeter. In squid giant axons, the amplitude of the observed outward movement of the surface was small.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Iwasa, K -- Tasaki, I -- Gibbons, R C -- New York, N.Y. -- Science. 1980 Oct 17;210(4467):338-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7423196" target="_blank"〉PubMed〈/a〉
    Keywords: *Action Potentials ; Animals ; Axons/*physiology/ultrastructure ; Brachyura ; Decapodiformes ; Hydrostatic Pressure ; Time Factors
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    Gene transfer given a new twist (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-04-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1980 Apr 25;208(4442):386-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6929109" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Bone Marrow Cells ; Cell Survival/drug effects ; *DNA, Recombinant ; Drug Resistance ; Genetic Engineering/*methods ; Methotrexate/*pharmacology ; Mice ; Selection, Genetic
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    Vasoactive intestinal peptide: a possible transmitter of nonadrenergic relaxation of guinea pig airways (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-12-12
    Description: Vasoactive intestinal peptide, a smooth-muscle relaxant neuropeptide with neurotransmitter properties, was relaxed during electrical field stimulation of guinea pig trachea. The amount released correlated with the degree of relaxation, and the release was blocked by tetrodotoxin. Prior incubation of the trachea with antiserum to vasoactive intestinal peptide reduced the relaxation. Thus vasoactive intestinal peptide may mediate the nonadrenergic relaxation of tracheal smooth muscle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Matsuzaki, Y -- Hamasaki, Y -- Said, S I -- HL-14187/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1980 Dec 12;210(4475):1252-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6254154" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic Fibers/*physiology ; Animals ; Antigen-Antibody Reactions ; Electric Stimulation ; Female ; Gastrointestinal Hormones/*physiology ; Humans ; Mice ; *Muscle Contraction ; *Muscle Relaxation ; Muscle, Smooth/drug effects ; Neural Inhibition ; Synaptic Transmission ; Tetrodotoxin/pharmacology ; Trachea/*innervation ; Vasoactive Intestinal Peptide/immunology/*physiology
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    Swifter action sought on food contamination (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-01-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1980 Jan 11;207(4427):163.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6765994" target="_blank"〉PubMed〈/a〉
    Keywords: Costs and Cost Analysis ; Food Contamination/analysis/*prevention & control ; Government Agencies ; Humans ; Polychlorinated Biphenyls/analysis ; Time Factors ; United States ; United States Food and Drug Administration
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    Tumor-promoting phorbol esters stimulate hematopoietic colony formation in vitro (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-04-25
    Description: Tumor-promoting phorbol esters stimulated mouse bone marrow cells to form myeloid colonies in agar cultures without added colony-stimulating factors. The colony-stimulating ability of various phorbol esters correlated well with their ability to promote skin tumors in vivo. These results suggest that phorbol esters mimic the action of specific colony-stimulating factors that regulate growth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stuart, R K -- Hamilton, J A -- New York, N.Y. -- Science. 1980 Apr 25;208(4442):402-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6245446" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division/drug effects ; Cells, Cultured ; *Colony-Forming Units Assay ; Colony-Stimulating Factors/pharmacology ; Dose-Response Relationship, Drug ; Hematopoietic Stem Cells/*drug effects ; Macrophages/physiology ; Mice ; Monocytes/physiology ; Phorbol Esters/pharmacology ; Phorbols/*pharmacology ; Receptors, Cell Surface/drug effects ; Structure-Activity Relationship ; Tetradecanoylphorbol Acetate/*pharmacology
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    Electrophysiological signs of split-second decision-making (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-08
    Description: When young adults detected auditory stimuli at split-second intervals, different components of the event-related brain potentials showed markedly different speeds of recovery. The P3 component (latency 300 to 350 milliseconds) was fully recovered at intervals of less than 1.0 second, while the N1--P2 components (latencies 100 to 180 milliseconds) were markedly attenuated with stimulus repetition even at longer interstimulus intervals. Thus, the N1--P2 recovers much more slowly than a subject's ability to evaluate signals, whereas the P3 appears to be generated at the same high rates as the decision processes with which it is associated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Woods, D L -- Hillyard, S A -- Courchesne, E -- Galambos, R -- New York, N.Y. -- Science. 1980 Feb 8;207(4431):655-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7352278" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Auditory Perception/physiology ; Brain/*physiology ; Cognition/physiology ; Decision Making/*physiology ; Evoked Potentials ; Humans ; Memory/physiology ; Time Factors
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    Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-04
    Description: Hybrid cells secreting antibodies against sporozoites of Plasmodium berghei were obtained by fusion of plasmacytoma cells with immune murine spleen cells. The monoclonal antibodies bound to a protein with an apparent molecular weight of 44,000 (Pb44), which envelopes the surface membrane of sporozoites. Incubation of sporozoites in vitro with antibodies to Pb44 abolished their infectivity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yoshida, N -- Nussenzweig, R S -- Potocnjak, P -- Nussenzweig, V -- Aikawa, M -- New York, N.Y. -- Science. 1980 Jan 4;207(4426):71-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6985745" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibodies ; Antigens, Surface ; Clone Cells/immunology ; Hybrid Cells/immunology ; Malaria/*immunology ; Membrane Proteins/immunology ; Mice ; Molecular Weight ; Myeloma Proteins/immunology ; Neoplasms, Experimental/immunology ; Plasmacytoma/immunology ; Plasmodium berghei/*immunology ; Spleen/immunology
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    Visual effects of auditory deprivation: common intermodal and intramodal factors (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-08
    Description: Visual temporal acuity, as measured by the critical flicker frequency decreased and then increased during 24 hours of auditory deprivation. This intermodal effect is similar to intramodal changes in the critical flicker frequency of the nonoccluded eye during monocular deprivation; a single mechanism appears to underlie both phenomena.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bross, M -- Harper, D -- Sicz, G -- New York, N.Y. -- Science. 1980 Feb 8;207(4431):667-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7352281" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Auditory Perception/*physiology ; Denervation ; Flicker Fusion ; Humans ; Reticular Formation/physiology ; Time Factors ; Visual Perception/*physiology
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    DNA sequences mediating class switching in alpha-immunoglobulins (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-09-19
    Description: Immunoglobulin class switching involves specific DNA rearrangements of the gene segments coding for heavy chain constant regions (CH) during B lymphocyte differentiation. In two different cases of C mu to C alpha switching examined here (T15 and M603) and one taken from the literature (MC101), three different sites on the 5' side of C mu and three different sites on the 5' side of C alpha are joined together in the process of CH switching. The sequences surrounding the three germ-line C alpha sites of recombination are highly conserved blocks of 30 nucleotides that may serve as recognition sequences for CH switching to the C alpha gene. This putative recognition sequence is repeated 17 times in approximately 1400 nucleotides of the germ-line Calpha 5' flanking sequence. The lack of homology between this C alpha sequence and sequences reported for the C gamma 1 and C gamma 2b switch sites suggests that heavy chain switching is mediated by class-specific recognition sequences and, presumably, class-specific regulatory mechanisms. In addition, it appears that in one example (MC101) CH switching progressed from C mu to C alpha to C gamma 1. This switching pathway may present difficulties for the simple deletional model of CH switching.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davis, M M -- Kim, S K -- Hood, L E -- AI 09072/AI/NIAID NIH HHS/ -- GM 07616/GM/NIGMS NIH HHS/ -- PCM76-81546/PC/NCI NIH HHS/ -- New York, N.Y. -- Science. 1980 Sep 19;209(4463):1360-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6774415" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes/*immunology ; Base Sequence ; DNA/genetics ; *Genes ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin Variable Region/genetics ; Immunoglobulin alpha-Chains/*genetics ; Immunoglobulin mu-Chains/*genetics ; Immunoglobulins/*genetics ; Mice ; Myeloma Proteins/genetics ; Recombination, Genetic
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    Two coronaviruses isolated from central nervous system tissue of two multiple sclerosis patients (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-08-22
    Description: Two coronaviruses were isolated from brain material obtained at autopsy from two multiple sclerosis patients. The viruses were neutralized by serum and spinal fluid from these patients. Although most of the population have antibody to these virus isolates, multiple sclerosis patients have slightly higher concentrations of serum antibody than controls. The results suggest that coronaviruses should be considered as one additional virus with a potential implication in the etiology of multiple sclerosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burks, J S -- DeVald, B L -- Jankovsky, L D -- Gerdes, J C -- New York, N.Y. -- Science. 1980 Aug 22;209(4459):933-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7403860" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Animals ; Antibodies, Viral/analysis ; Brain/*microbiology ; Cells, Cultured ; Coronaviridae/immunology/*isolation & purification ; Female ; Freezing ; Humans ; Male ; Mice ; Middle Aged ; Multiple Sclerosis/*microbiology/pathology
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    Subcellular origin of cholinergic transmitter release from mouse brain (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-11-07
    Description: Samples of minced mouse forebrain were treated in a way that resulted in a high ratio of false cholinergic transmitter (acetylhomocholine) to true transmitter (acetylcholine) in a synaptic vesicle fraction, and a low ratio of false to true transmitter in the nerve terminal cytoplasm. The spontaneous release of cholinergic transmitters from this minced tissue occurred independently of calcium and had a ratio of false to true transmitter similar to that of the cytoplasm, whereas the evoked transmitter release required calcium and had a ratio of false to true transmitter similar to that of the vesicular fraction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carroll, P T -- Aspry, J M -- New York, N.Y. -- Science. 1980 Nov 7;210(4470):641-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7433989" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/analogs & derivatives/*metabolism ; Animals ; Brain/*metabolism ; Calcium/physiology ; Cytoplasm/metabolism ; Exocytosis/drug effects ; Lithium/pharmacology ; Magnesium/physiology ; Male ; Mice ; Potassium/pharmacology ; Synaptic Vesicles/metabolism
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    Asymmetrically permeable membrane channels in cell junction (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-15
    Description: Asymmetric membrane junctions were formed in culture by pairing two cell types which, in their respective homologous junctions, have cell-cell channels of different permselectivities. The channels in the asymmetric junction, presumably made of unequal channel precursors, displayed directional permselectivity; fluorescent labeled glutamic acid (700 daltons), but not smaller and less polar permeant molecules, traversed the junction more readily in one direction than in the other. The favored direction was the one where the permeant passed first through the cell membrane that would have the less restrictive channels in a homologous junction. This directional selectivity requires no electric field across the junction and is thus distinct from a rectifying junction. The physiological potential of such directional molecular sieving for partitioning communication between tissue cells of different function and developmental fate are discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flagg-Newton, J L -- Loewenstein, W R -- New York, N.Y. -- Science. 1980 Feb 15;207(4432):771-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7352287" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport ; *Cell Communication ; Cell Line ; Cell Membrane Permeability ; Fluorescent Dyes ; Intercellular Junctions/*physiology ; Ion Channels/*physiology/ultrastructure ; Membrane Potentials ; Mice
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    Therapy of spontaneous metastases by intravenous injection of liposomes containing lymphokines (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-06-27
    Description: Mice of two different strains were injected subcutaneously with spontaneously metastasizing syngeneic melanomas. After 4 to 6 weeks, the local tumors were removed and, 3 days after surgery, treatment of the metastases was initiated. The treatment consisted of intravenous injections of liposomes containing lymphokines or control supernatant fluids. Liposomes were injected twice weekly for 3 weeks, and the mice were killed 2 weeks later. Seventy-three percent of the mice injected with liposomes containing lymphokines were free of metastases, whereas only 10 percent of the mice treated with control liposomes were tumor-free. These experiments suggest that this form of therapy may provide a valuable addition to the more conventional approaches to the eradication of cancer metastases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fidler, I J -- New York, N.Y. -- Science. 1980 Jun 27;208(4451):1469-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7384789" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Liposomes/*therapeutic use ; Lymphokines/*therapeutic use ; Melanoma/*drug therapy ; Mice ; Mice, Inbred C3H ; Mice, Inbred C57BL ; *Neoplasm Metastasis ; Neoplasms, Experimental/drug therapy ; Species Specificity
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    Human cutaneous lieshmania in a mouse macrophage line: propagation and isolation of intracellular parasites (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-09-12
    Description: A mouse macrophage line, J774G8, supports continuous and prolific intracellular growth of Leishmania mexicana amazonensis, the etiological agent of a South American cutaneous leishmaniasis. The intracellular parasites from these infected cultures can be isolated with high recovery rate and purity by simple Percoll gradient centrifugation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chang, K P -- New York, N.Y. -- Science. 1980 Sep 12;209(4462):1240-42.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7403880" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Disease Models, Animal ; Humans ; Leishmania/growth & development ; Leishmaniasis/*parasitology/pathology ; Macrophages/*parasitology ; Mice
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    Seizure protection and increased nerve-terminal GABA: delayed effects of GABA transaminase inhibition (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-04-18
    Description: Changes in gamma-aminobutyric acid (GABA) occurring in the presence and in the absence of GABA-containing nerve terminals were estimated in rats in which the dense GABA projection to the substantia nigra was surgically destroyed on one side of the brain. The net increase in GABA of the denervated nigra was compared with that of the intact nigra at various times after a single injection of gama-vinyl-GABA, which irreversibly inhibits GABA transaminase. Total GABA reached a maximum within 12 hours, but the GABA pool associated with nerve terminals did not increase until 36 hours and peaked at 60 hours. The onset and peak of anticonvulsant activity against maximal electroshock seizures directly paralleled the time course for the increase in GABA in nerve terminals, but was not positively correlated with that independent of the terminals. This result supports the concept that elevating GABA in nerve terminals facilitates GABA-mediated synaptic transmission and predicts anticonvulsant activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gale, K -- Iadarola, M J -- New York, N.Y. -- Science. 1980 Apr 18;208(4441):288-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6768130" target="_blank"〉PubMed〈/a〉
    Keywords: 4-Aminobutyrate Transaminase/*antagonists & inhibitors ; Aminocaproates/*pharmacology ; Aminooxyacetic Acid/pharmacology ; Animals ; Brain/*metabolism ; Cell Compartmentation ; Electroshock ; Nerve Endings/metabolism ; Rats ; Seizures/*physiopathology ; Substantia Nigra/metabolism ; Time Factors ; Transaminases/*antagonists & inhibitors ; Valproic Acid/pharmacology ; Vigabatrin ; gamma-Aminobutyric Acid/*physiology
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    Strain dependence of the antiproliferative action of interferon on murine erythroid precursors (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-11
    Description: Electrophoretically pure mouse interferon inhibits erythropoietin-dependent proliferation of committed erythroid precursors (CFU-E) obtained either from adult mouse bone marrow or from 14-day fetal mouse livers. The degree of inhibition is significantly influenced by the genotype of the cell donor; about ten times as much interferon is required to inhibit proliferation of CFU-E from C57BL/6 than is needed for comparable inhibition of CFU-E from BALB/c or Swiss mice. These strain-dependent results point to the existence of genes that influence the degree of the inhibitory effect of interferon on cell multiplication.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallien-Lartigue, O -- Carrez, D -- De Maeyer, E -- De Maeyer-Guignard, J -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):292-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6155700" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Marrow/drug effects/*physiology ; Cell Division/drug effects ; Embryo, Mammalian ; Erythropoiesis/*drug effects ; Female ; Interferons/*pharmacology ; Liver/drug effects/physiology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Species Specificity
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    Recall (versus recognition) of taste and immunization against aversive taste anticipations based on illness (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-15
    Description: Two experiments show that, after taste-aversion conditioning, rats can use external retrieval cues to recall or anticipate the aversive taste solution and avoid its location without making contact with the flavor. They also show that the rat's avoidance of a conditioned aversive taste and its consumption of the aversive flavored solution can be attenuated by giving it prior runway training in which taste reward is given inconsistently on a partial reinforcement schedule.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, J S -- Amsel, A -- New York, N.Y. -- Science. 1980 Aug 15;209(4458):831-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7403850" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Avoidance Learning/*physiology ; Conditioning (Psychology) ; Extinction, Psychological ; Female ; Lithium ; Male ; Memory/*physiology ; Mental Recall/*physiology ; Rats ; Reinforcement (Psychology) ; Sodium Chloride ; Taste/*physiology ; Time Factors
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    Catecholamine-induced alteration in sedimentation behavior of membrane bound beta-adrenergic receptors (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-10-01
    Description: Incubation of astrocytoma cells with catecholamines results in a decrease in catecholamine-stimulated adenylate cyclase activity and a concomitant alteration in the sedimentation properties of particulate beta-adrenergic receptors. The altered receptors exhibit agonist binding properties similar to those of receptors that are "uncoupled" from adenylate cyclase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harden, T K -- Cotton, C U -- Waldo, G L -- Lutton, J K -- Perkins, J P -- GM 25163/GM/NIGMS NIH HHS/ -- HL 22490/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1980 Oct;210(4468):441-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6254143" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/metabolism ; Astrocytoma ; Cell Line ; Centrifugation, Density Gradient ; Concanavalin A/pharmacology ; Endocytosis ; Humans ; Isoproterenol/*metabolism ; Protein Conformation ; Receptors, Adrenergic/*metabolism ; Receptors, Adrenergic, beta/*metabolism ; Time Factors
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    New protein sequenator with increased sensitivity (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-02-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hunkapiller, M W -- Hood, L E -- New York, N.Y. -- Science. 1980 Feb 1;207(4430):523-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7352258" target="_blank"〉PubMed〈/a〉
    Keywords: *Amino Acid Sequence ; Animals ; Humans ; Mice ; *Proteins/genetics
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    Role of nitrogen dioxide in the biosynthesis of nitraosamines in mice (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-03-28
    Description: Groups of three to four mice were gavaged with aqueous solutions of 2 milligrams of morpholine, after which they were exposed to nitrogen dioxide in inhalation chambers at concentrations of 0.2 to 50 parts per million for up to 4 hours. At sequential intervals during the exposure, mice were frozen and pulverized in liquid nitrogen, and the mice powder was extracted with ice-cold 35 percent aqueous methanol and dichloromethane; organic-phase concentrates were analyzed for N-nitrosomorpholine with a thermal energy analyzer interfaced to a gas chromatograph. The N-nitrosomorpholine yields, ranging up to about 2.3 micrograms per mouse, were time-dependent relative to the duration of exposure to nitrogen dioxide and dose-dependent relative to the concentrations of nitrogen dioxide; control levels (in mice that were gavaged with morpholine or distilled water and then exposed to air instead of nitrogen dioxide) were less than 5 nanograms per mouse. These preliminary studies demonstrate the in vivo nitrosating potential of nitrogen oxides.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Iqbal, Z M -- Dahl, K -- Epstein, S S -- New York, N.Y. -- Science. 1980 Mar 28;207(4438):1475-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7361099" target="_blank"〉PubMed〈/a〉
    Keywords: Amines/metabolism ; Animals ; Ascorbic Acid/pharmacology ; Biotransformation ; Dose-Response Relationship, Drug ; Mice ; Morpholines/*metabolism ; Nitrogen Dioxide/antagonists & inhibitors/*metabolism ; Nitrosamines/*metabolism ; Time Factors
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    Natural killer cells help defend the body (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-11-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1980 Nov 7;210(4470):624-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6159684" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Humans ; Immunity, Cellular ; *Immunity, Innate ; Interferons/physiology ; Killer Cells, Natural/*immunology ; Mice ; Mice, Nude/immunology ; Neoplasms/*immunology ; Neoplasms, Experimental/immunology ; Virus Diseases/*immunology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 85
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    Cell variants showing differential susceptibility to ultraviolet light--induced transformation (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-25
    Description: Six variant clones isolated from a subclone of BALB/3T3-A31 clone were classified into three groups according to their different susceptibilities to cell transformation by ultraviolet light irradiation: highly susceptible, intermediately susceptible, and resistant. All variant clones showed similar susceptibility to cytotoxic effects induced by ultraviolet light.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kakunaga, T -- Crow, J D -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):505-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7394516" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Transformation, Neoplastic/*radiation effects ; Clone Cells ; Dose-Response Relationship, Radiation ; Genetic Variation ; Mice ; Transformation, Genetic/*radiation effects ; *Ultraviolet Rays
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  • 86
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    Hybridomas revisited (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-17
    Description: In the report by John C. Behrendt et al. "Aeromagnetic and radio echo ice-sounding measurements show much greater area of the Dufek Intrusion, Antarctica" (29 Aug., p. 1014), the word "expedition" should have read "exploitation" in line 13 of the first paragraph on page 1014. Also, in line 2 of the next to last paragraph on page 1016, "50 to 60 cm/sec(2)" should have read "50 to 60 (cm sec(2)) x 10(-3)."〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koprowski, H -- Croce, C -- New York, N.Y. -- Science. 1980 Oct 17;210(4467):248.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7423184" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibodies ; Antibodies, Viral ; Cell Line ; *Clone Cells ; Mice ; *Patents as Topic ; Plasmacytoma/immunology
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  • 87
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    Absence of cross-tolerance to heroin in morphine-tolerant mice (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-04-04
    Description: Mice implanted with morphine pellets demonstrated a 30-fold increase in tolerance to subcutaneously administered morphine but showed no cross-tolerance to subcutaneously administered heroin. When given morphine intracerebroventricularly, the mice showed no tolerance to morphine or cross-tolerance to heroin. These observations depended on the presence of the morphine pellet. If the pellets were removed prior to determinations of potency, the expected responses--tolerance to morphine and cross-tolerance to heroin--were obtained. The blood-brain barrier may be a prime site for the expression of morphine tolerance in mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lange, D G -- Roerig, S C -- Fujimoto, J M -- Wang, R I -- New York, N.Y. -- Science. 1980 Apr 4;208(4439):72-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7361110" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood-Brain Barrier/drug effects ; Drug Interactions ; Drug Tolerance ; Heroin/administration & dosage/*pharmacology ; Mice ; Morphine/administration & dosage/*pharmacology
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  • 88
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    Opioid and nonopioid mechanisms of stress analgesia (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-05-09
    Description: Inescapable foot shock in rats caused profound analgesia that was antagonized by naloxone or dexamethasone when shock was delivered intermittently for 30 minutes, but not when it was delivered continuously for 3 minutes. Thus, depending only on its temporal characteristics, foot-shock stress appears to activate opioid or nonopioid analgesia mechanisms. Certain forms of stress may act as natural inputs to an endogenous opiate analgesia system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewis, J W -- Cannon, J T -- Liebeskind, J C -- New York, N.Y. -- Science. 1980 May 9;208(4444):623-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7367889" target="_blank"〉PubMed〈/a〉
    Keywords: *Analgesia ; Animals ; Dexamethasone/*pharmacology ; Electroshock ; Endorphins/*physiology ; Male ; Naloxone/pharmacology ; Pain/*physiopathology ; Pituitary Gland/physiology ; Rats ; Stress, Physiological/*physiopathology ; Time Factors
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  • 89
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    Assignment of the murine interferon sensitivity and cytoplasmic superoxide dismutase genes to chromosome 16 (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-11
    Description: Both hybrids of mouse and human microcells and whole cell hybrids generated by the fusion of primary mouse cells and SV40-transformed human fibroblasts were used to establish the syntenic association of the murine cytoplasmic superoxide dismutase and the interferon sensitivity genes on mouse chromosome 16. This assignment adds two new markers to chromosome 16 and provides another example of an evolutionarily conserved linkage. This finding also provides an animal model both for cellular responsiveness to interferon and for Down's syndrome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, P F -- Slate, D L -- Lawyer, F C -- Ruddle, F H -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):285-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6155698" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Transformation, Viral ; *Chromosomes, Human, 16-18 ; *Genes ; Humans ; Hybrid Cells/drug effects/*physiology ; Interferons/*pharmacology ; Karyotyping ; Mice ; Simian virus 40 ; Superoxide Dismutase/*genetics
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  • 90
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    Time: a new parameter for kinetic measurements in flow cytometry (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-11
    Description: The measure of time was used as an additional parameter on an existing flow cytometer to study the kinetics of enzyme activities and cell-stain interactions. By correlating all fluorescent signals from single cells with time, the dynamics of a reaction can be followed for several minutes. This advanced application of flow cytometry is easily implemented and can be incorporated into any flow cytometer that has two-parameter analysis capability.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Martin, J C -- Swartzendruber, D E -- New York, N.Y. -- Science. 1980 Jan 11;207(4427):199-201.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6153131" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cells, Cultured/enzymology ; Computers ; Cricetinae ; *Cytological Techniques ; DNA/metabolism ; Esterases/metabolism ; Kinetics ; Mice ; Spectrometry, Fluorescence/methods ; Staining and Labeling
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  • 91
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    Opiate receptor function may be modulated through an oxidation-reduction mechanism (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-06-06
    Description: Cupric ion, a thiol oxidant, caused naloxone-reversible analgesia when injected intracerebroventricularly in mice; its potency was close to that of morphine. Dithiothreitol, a thiol reductant, reversed the analgesia induced by cupric ion and antagonized analgesia induced by morphine. Oxidized dithiothreitol had no effect. These findings, together with evidence for redox modification of opiate receptor binding in vitro, suggest that a mechanism of oxidation-reduction of thiols may modulate opiate receptor function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marzullo, G -- Hine, B -- New York, N.Y. -- Science. 1980 Jun 6;208(4448):1171-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6246583" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*physiology ; Copper/antagonists & inhibitors/*pharmacology ; Dithiothreitol/pharmacology ; Male ; Mice ; Naloxone/pharmacology ; Oxidation-Reduction ; Pain/*physiopathology ; Rats ; Receptors, Opioid/drug effects/*physiology ; Sulfhydryl Compounds/pharmacology ; Zinc/pharmacology
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  • 92
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    New techniques for selective immune suppression increase transplant odds (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T A 2nd -- New York, N.Y. -- Science. 1980 Oct 3;210(4465):44-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6774417" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antilymphocyte Serum/therapeutic use ; Blood Transfusion ; Bone Marrow Transplantation ; Cyclosporins ; Drainage ; *Graft Survival/drug effects ; Haplorhini ; Heart Transplantation ; Humans ; Immunosuppression/*methods ; Immunosuppressive Agents/therapeutic use ; Infection Control ; Kidney Transplantation ; Lung Transplantation ; Lymphatic System/radiation effects ; Lymphocyte Depletion ; Mice ; Peptides, Cyclic/therapeutic use ; Rats ; T-Lymphocytes/drug effects/immunology ; Thoracic Duct/surgery ; Transplantation, Homologous
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  • 93
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    At least three human type alpha interferons: structure of alpha 2 (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-09-19
    Description: The sequence of a human leukocyte-derived complementary DNA (cDNA), Hif-2h, which directs the formation in Escherichia coli of a polypeptide, IFN-alpha 1, with interferon (IFN) activity has been described. A second IFN cDNA, Hif-SN206, which also elicits synthesis of a biologically active IFN, IFN-alpha 2, is described in this article. Whereas IFN-alpha 2 is twice as active on human as on bovine cells, IFN-alpha 1 is 10 to 20 times more active on bovine than on human cells. As deduced from the cDNA's, the messenger RNA's for the two IFN's differ in length and in 20 percent of the nucleotides; the mature IFN polypeptides differ in 17 percent of the amino acids. Both IFN-alpha 1 and IFN-alpha 2 differ from the lymphoblastoid IFN described by others. Therefore, at least three different IFN-alpha genes are expressed in man; studies on genomic DNA reveal the presence of at least eight IFN-related genes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Streuli, M -- Nagata, S -- Weissmann, C -- New York, N.Y. -- Science. 1980 Sep 19;209(4463):1343-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6158094" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; DNA, Recombinant ; Escherichia coli/genetics ; Genes ; Humans ; *Interferons/genetics ; Leukocytes ; Lymphocytes ; Mice ; RNA, Messenger/genetics ; Structure-Activity Relationship
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  • 94
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    Biochemical analysis of human T lymphocyte differentiation antigens T4 and T5 (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-25
    Description: Two major functionally distinct T cell subsets in man have been defined with heteroantiserums and monoclonal antibodies directed against stable cell surface antigens that appear during thymic ontogeny. A monoclonal antibody to T4 antigen (anti-T4) is reactive with the peripheral inducer T cell population while a monoclonal antibody to T5 antigen (anti-T5) is reactive with the cytotoxic and suppressor population. Immunoprecipitation and electrophoresis on sodium dodecyl sulfate polyacrylamide gel were used to show that on human thymocytes or peripheral T cells the T4 antigen is a single 62,000-dalton glycoprotein while the T5 antigen is a complex of two glycoproteins, one being 30,000 daltons and the other 32,000 daltons. Similar glycoproteins have been isolated with antibodies to murine Lyt 1 and Lyt 2,3 antigens. Both the antigens defining the phenotypes of inducer and suppressor populations in man and mouse are structurally homologous.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Terhorst, C -- van Agthoven, A -- Reinherz, E -- Schlossman, S -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):520-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6967228" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies ; Antigens, Surface/*analysis ; Electrophoresis, Polyacrylamide Gel ; Glycoproteins/analysis ; Humans ; Mice ; Molecular Weight ; T-Lymphocytes/*immunology ; Thymus Gland/immunology
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  • 95
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    Mouse interferons: amino terminal amino acid sequences of various species (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-01
    Description: Mouse interferons of three size classes (A, 35,000 to 40,000 daltons; B, 26,000 to 33,000 daltons; and C, 20,000 daltons) were purified from Ehrlich ascites tumor cells infected with Newcastle disease virus. The sequences of the first 24 amino acids (No. 17 has not been identified) of interferons A and B are identical. The sequence of the first 20 amino acids of interferon C differs from that of A and B in 18 positions. There is partial homology in amino terminal sequence between mouse interferons A (or B) and a human fibroblast interferon and between mouse interferon C and a human lymphoblastoid interferon.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taira, H -- Broeze, R J -- Jayaram, B M -- Lengyel, P -- Hunkapiller, M W -- Hood, L E -- New York, N.Y. -- Science. 1980 Feb 1;207(4430):528-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7352261" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Biological Evolution ; Carcinoma, Ehrlich Tumor/analysis ; Cells, Cultured ; Glycoproteins/analysis ; *Interferons/genetics ; Mice ; Molecular Weight
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  • 96
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    UCLA gene therapy racked by friendly fire (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, N -- New York, N.Y. -- Science. 1980 Oct 31;210(4469):509-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6932738" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Marrow Cells ; Ethics Committees, Research ; Gene Expression Regulation ; *Genes ; Genetic Engineering/*methods ; Globins/*genetics ; Humans ; Mice ; Risk Assessment ; Thalassemia/*genetics ; Universities
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  • 97
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    Modulation of epidermal growth factor receptors on 3T3 cells by platelet-derived growth factor (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-12-19
    Description: Platelet-derived growth factor does not compete with epidermal growth factor (EGF) for binding to EGF receptors on the murine 3T3 cell surface, but it modulates EGF receptors in two ways: (i) it induces a transient down regulation of EGF receptors and (ii) it inhibits EGF-induced down regulation of EGF receptors. These data suggest a common cellular internalization mechanism for the receptors for both hormones.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wrann, M -- Fox, C F -- Ross, R -- AM-25826/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1980 Dec 19;210(4476):1363-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6254158" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding, Competitive ; Blood Platelets/*physiology ; Cell Line ; Endocytosis ; Epidermal Growth Factor/*metabolism ; Growth Substances/*pharmacology ; Mice ; Peptides/*metabolism/*pharmacology ; Platelet-Derived Growth Factor ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/*drug effects/metabolism
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  • 98
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    Acquisition of a memory skill (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-06-06
    Description: After more than 230 hours of practice in the laboratory, a subject was able to increase his memory span from 7 to 79 digits. His performance on other memory tests with digits equaled that of memory experts with lifelong training. With an appropriate mnemonic system, there is seemingly no limit to memory performance with practice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ericcson, K A -- Chase, W G -- Faloon, S -- New York, N.Y. -- Science. 1980 Jun 6;208(4448):1181-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7375930" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Association Learning/physiology ; Humans ; Male ; Memory/*physiology ; Memory, Short-Term/physiology ; Time Factors
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  • 99
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    Relation of mammalian sperm chromatin heterogeneity to fertility (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-12-05
    Description: Flow cytometry of heated sperm nuclei revealed a significant decrease in resistance to in situ denaturation of spermatozoal DNA in samples from bulls, mice, and humans of low or questionable fertility when compared with others of high fertility. Since thermal denaturation of DNA in situ depends on chromatin structure, it is assumed that changes in sperm chromatin conformation may be related to the diminished fertility. Flow cytometry of heated sperm nuclei may provide a new and independent determinant of male fertility.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Evenson, D P -- Darzynkiewicz, Z -- Melamed, M R -- New York, N.Y. -- Science. 1980 Dec 5;210(4474):1131-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7444440" target="_blank"〉PubMed〈/a〉
    Keywords: Acridine Orange ; Animals ; Cattle ; Cell Nucleus/ultrastructure ; Chromatin/*ultrastructure ; *Fertility ; Hot Temperature ; Humans ; Infertility, Male/*pathology ; Male ; Mice ; Nucleic Acid Denaturation ; Sperm Head/*ultrastructure ; Spermatozoa/*physiology/*ultrastructure ; Zinc/deficiency
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  • 100
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    Suppression of prolactin secretion in normal young women by 2-hydroxyestrone (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-03
    Description: The nonuterotropic natural estrogen 2-hydroxyestrone administered to normal young women results in a prompt and profound suppression of serum prolactin in most of the subjects. With the exception of dopamine, this is the only endogenous material known to strongly inhibit prolactin secretion, and its action suggests that the physiological regulation of prolactin by estrogens in the human is dual in nature, consisting of stimulation by estradiol and inhibition by its catechol estrogen metabolite.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fishman, J -- Tulchinsky, D -- CA 22795/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1980 Oct 3;210(4465):73-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7414322" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Drug Administration Schedule ; Estrogens/physiology ; Estrone/*analogs & derivatives ; Female ; Humans ; Hydroxyestrones/*pharmacology ; Prolactin/blood/*secretion ; Time Factors
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