Publication Date:
1980-10-03
Description:
Antidepressants compete at several neurotransmitter receptor binding site, but drug affinities do not correlate with clinical efficacy. Long-term, but not short-term, antidepressant treatment decreases the numbers of both serotonin and beta-adrenergic receptors. The decrease in the number of receptor sites is most marked for [3H]spiroperidol-labeled serotonin receptors and is characteristic for antidepressants of several classes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peroutka, S J -- Snyder, S H -- 5T32GM0309/GM/NIGMS NIH HHS/ -- DA00266/DA/NIDA NIH HHS/ -- MH18501/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1980 Oct 3;210(4465):88-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6251550" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antidepressive Agents/administration & dosage/metabolism/*pharmacology
;
Frontal Lobe/drug effects
;
Male
;
Rats
;
Receptors, Adrenergic, alpha/metabolism
;
Receptors, Adrenergic, beta/drug effects/metabolism
;
Receptors, Dopamine/metabolism
;
Receptors, Histamine H1/metabolism
;
Receptors, Muscarinic/metabolism
;
Receptors, Serotonin/*drug effects/metabolism
;
Spiperone/metabolism
;
Time Factors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
