ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Female  (132)
  • Mice  (83)
  • Kinetics  (23)
  • Rats, Inbred Strains
  • American Association for the Advancement of Science (AAAS)  (222)
  • Annual Reviews
  • Blackwell Publishing Ltd
  • 1980-1984  (222)
  • 1955-1959
  • 1930-1934
  • 1980  (222)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (222)
  • Annual Reviews
  • Blackwell Publishing Ltd
  • Springer  (10)
  • Wiley-Blackwell  (1)
Years
  • 1980-1984  (222)
  • 1955-1959
  • 1930-1934
Year
  • 1
    facet.materialart.
    Unknown
    Amino acid acylation: a mechanism of nitrogen excretion in inborn errors of urea synthesis (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-08
    Description: Treatment of a patient deficient in carbamyl phosphate synthetase with benzoate or phenylacetic acid resulted in an increase in urinary nitrogen, which could be accounted for by the respective amino acid acylation product, hippurate or phenylacetylgultamine. Benzoate treatment of four hyperammonemic comatose patients led to clinical improvement and a return of plasma ammonium levels toward normal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brusilow, S -- Tinker, J -- Batshaw, M L -- New York, N.Y. -- Science. 1980 Feb 8;207(4431):659-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6243418" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Amino Acid Metabolism, Inborn Errors/*drug therapy ; Amino Acids/blood ; Ammonia/blood ; Benzoates/*therapeutic use ; Carbamoyl-Phosphate Synthase (Ammonia)/*deficiency ; Child ; Female ; Glutamine/metabolism ; Glycine/metabolism ; Hippurates/urine ; Humans ; Infant ; Male ; Nitrogen/blood ; *Ornithine Carbamoyltransferase Deficiency Disease ; Phenylacetates/*therapeutic use ; Phosphotransferases/*deficiency
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Fetal exposure to narcotics: neonatal sleep as a measure of nervous system disturbance (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-01
    Description: Newborn infants, chronically exposed in utero to low doses of methadone with or without concomitant heroin, display more rapid eye movement sleep and less quiet sleep than control infants, while babies fetally exposed to both opiates and nonopiates have less organization of sleep states. Other perinatal factors, such as birth weight and gestational age, are related more to the amount of fetal drug exposure than to the type.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dinges, D F -- Davis, M M -- Glass, P -- New York, N.Y. -- Science. 1980 Aug 1;209(4456):619-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7190326" target="_blank"〉PubMed〈/a〉
    Keywords: Birth Weight ; Female ; Heroin/*adverse effects ; Heroin Dependence/drug therapy ; Humans ; Infant, Newborn ; Infant, Newborn, Diseases/*chemically induced ; Maternal-Fetal Exchange ; Methadone/*adverse effects/therapeutic use ; Nervous System Diseases/*chemically induced ; Pregnancy ; Sleep/*drug effects ; Substance-Related Disorders
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    L-Ornithine decarboxylase:an essential role in early mammalian embryogenesis (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-05-02
    Description: The highly selective, enzyme-activated, irreversible inhibitor of L-ornithine decarboxylase, DL-alpha-difluoromethylornithine, suppresses the increase in uterine L-ornithine decarboxylase activity associated with early embryogenesis in the mouse and arrests embryonic development at that stage. Contragestational effects were confirmed in the rat and rabbit. An increase in L-ornithine decarboxylase activity that leads to a rapid increase in putrescine concentration appears to be essential during a critical period after implantation for continued mammalian embryonal growth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fozard, J R -- Part, M L -- Prakash, N J -- Grove, J -- Schechter, P J -- Sjoerdsma, A -- Koch-Weser, J -- New York, N.Y. -- Science. 1980 May 2;208(4443):505-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6768132" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosylmethionine Decarboxylase/metabolism ; Animals ; Carboxy-Lyases/*physiology ; Eflornithine ; Embryo, Mammalian/drug effects/*physiology ; Female ; Gestational Age ; Mice ; Ornithine/*analogs & derivatives/pharmacology ; Ornithine Decarboxylase/*physiology ; Ornithine Decarboxylase Inhibitors ; Polyamines/metabolism ; Pregnancy ; Rabbits ; Rats ; Uterus/drug effects/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    Bioactive conformation of luteinizing hormone-releasing hormone: evidence from a conformationally constrained analog (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-11-07
    Description: An analog of luteinizing hormone-releasing hormone containing a gamma-lactam as a conformational constraint has been prepared with the use of a novel cyclization of a methionine sulfonium salt. The analog is more active as a luteinizing hormone-releasing hormone agonist that the parent hormone, and provides evidence for a bioactive conformation containing a beta-turn.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Freidinger, R M -- Veber, D F -- Perlow, D S -- Brooks, J R -- Saperstein, R -- New York, N.Y. -- Science. 1980 Nov 7;210(4470):656-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7001627" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Biological Assay ; Cells, Cultured ; Female ; *Gonadotropin-Releasing Hormone/analogs & derivatives ; Hydrogen Bonding ; Lactams ; Protein Conformation ; Rats ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    Doridosine: a new hypotensive N-methylpurine riboside from the nudibranch Anisodoris nobilis (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-11
    Description: A new N-methylpurine riboside (doridosine), probably N1-Methylisoguanosine, was isolated from the digestive glands of a nudibranch. Doridosine produces prolonged hypotension and bradycardia in anesthetized rats, decreases the rate and the amplitude of contraction of guinea pig atria in vitro, and causes the heart rate in anesthetized mice to be reduced by 50 percent for many hours after which the animals recover completely.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fuhrman, F A -- Fuhrman, G J -- Kim, Y H -- Pavelka, L A -- Mosher, H S -- New York, N.Y. -- Science. 1980 Jan 11;207(4427):193-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7350655" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antihypertensive Agents/*isolation & purification ; Guanosine/*analogs & derivatives/isolation & purification/pharmacology ; Guinea Pigs ; Heart Rate/drug effects ; Mice ; Mollusca/analysis ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 6
    facet.materialart.
    Unknown
    Survival of mice receiving melanoma transplants is promoted by hydroquinone (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-04-25
    Description: In BALB/c female mice with melanoma transplants, the incidence of "takes" is decreased and survival is increased by hydroquinone, a melanocytolytic agent. The mechanism of drug action is suggested by via DNA. The significant and high degree of positive response to hydroquinone treatment in vivo is encouraging for the clinical management of melanoma with melanocytolytic agents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chavin, W -- Jelonek, E J Jr -- Reed, A H -- Binder, L R -- New York, N.Y. -- Science. 1980 Apr 25;208(4442):408-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7367868" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Female ; Hydroquinones/metabolism/*therapeutic use ; Melanocytes/metabolism ; Melanoma/*drug therapy ; Mice ; Neoplasm Transplantation ; Neoplasms, Experimental/drug therapy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 7
    facet.materialart.
    Unknown
    Oral contraceptives, lanosterol, and platelet hyperactivity in rat (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-11-07
    Description: Lanosterol, a cholesterol precursor that increases considerably in the platelets of rats treated with oral contraceptives, was incubated with either platelet-rich plasma or washed platelet suspension. After 2 minutes there was a remarkable dose-related increase in platelet activity. This platelet hyperactivity was measured by clotting time and platelet aggregation could not be reproduced by cholesterol or ethinylestradiol.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ciavatti, M -- Dumont, E -- Benoit, C -- Renaud, S -- New York, N.Y. -- Science. 1980 Nov 7;210(4470):642-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7433990" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Coagulation/*drug effects ; Blood Platelets/*drug effects ; Contraceptives, Oral/*pharmacology ; Dose-Response Relationship, Drug ; Female ; Lanosterol/*pharmacology ; Platelet Aggregation/*drug effects ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 8
    facet.materialart.
    Unknown
    Single-nutrient microbial competition: qualitative agreement between experimental and theoretically forecast outcomes (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-28
    Description: When microbial strains compete for the same limiting nutrient in continuous culture, resource-based competition theory predicts that only one strain will survive and all others will die out. The surviving strain expected from theory will be the one with the smallest subsistence or "break-even" concentration of the limiting resource, a concentration defined by the J parameter. This prediction has been confirmed in the case of auxotrophic bacterial strains competing for limiting tryptophan. Because the value of J can be measured on the strains grown alone, the theory can predict the qualitative outcomes of mixed-growth competition in advance of actual competition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hansen, S R -- Hubbell, S P -- New York, N.Y. -- Science. 1980 Mar 28;207(4438):1491-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6767274" target="_blank"〉PubMed〈/a〉
    Keywords: Bacteria/*growth & development ; Culture Media ; Drug Resistance, Microbial ; Escherichia coli/growth & development ; Kinetics ; Models, Theoretical ; Nalidixic Acid/pharmacology ; Nutritional Physiological Phenomena ; Pseudomonas aeruginosa/growth & development ; Tryptophan/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 9
    facet.materialart.
    Unknown
    Identical twins reared apart (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1980 Mar 21;207(4437):1323-5, 1327-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7188816" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Environment ; Female ; Genetics, Medical ; Humans ; Intelligence ; Male ; Pregnancy ; Twins/*psychology ; Twins, Monozygotic/*psychology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 10
    facet.materialart.
    Unknown
    Cytostructural localization of a tumor-associated antigen (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-10
    Description: Tumor cell membrane glycoproteins may be involved in the induction of tumor immunity or in the escape of tumors from immunologic defense mechanisms. Forty-four benign and malignant breast lesions were examined for the presence of a carbohydrate precursor antigen (T antigen) of the human blood group system MN. T antigen was demonstrated by means of an immunohistochemical technique to detect tissue binding of peanut agglutinin, a plant lectin, with affinity for T antigen. Malignant breast lesions showed a pattern of T antigen expression different from that of benign breast tissues. A possible role for T antigen in the modulation of the immune response to breast carcinoma is suggested.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Howard, D R -- Batsakis, J G -- IR23 CA 28128-01/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1980 Oct 10;210(4466):201-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6997995" target="_blank"〉PubMed〈/a〉
    Keywords: Antibody Formation ; *Antigens, Neoplasm ; Arachis ; Breast Neoplasms/*immunology/ultrastructure ; Cytoplasm/immunology ; Female ; Glycoproteins/immunology ; Humans ; Immunoenzyme Techniques ; Lectins ; MNSs Blood-Group System ; Plant Lectins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 11
    facet.materialart.
    Unknown
    Olfactory sensitivity in humans: genetic versus environmental control (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-05-09
    Description: Olfactory sensitivity to acetic acid, isobutyric acid, and 2-sec-butyl-cyclohexanone was tested in 97 adult male twin pairs to determine the extent to which variation in odor perception was genetically determined. Analysis of the data revealed no evidence for heritability of olfactory sensitivity. However, factors significantly associated with odor perception included cigar, pipe, and cigarette smoking; body fatness; alcohol consumption; and diabetes mellitus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hubert, H B -- Fabsitz, R R -- Feinleib, M -- Brown, K S -- New York, N.Y. -- Science. 1980 May 9;208(4444):607-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7189296" target="_blank"〉PubMed〈/a〉
    Keywords: Acetates ; Adult ; Alcohol Drinking ; Butyrates ; Cyclohexanones ; *Environment ; Female ; *Genes ; Humans ; Male ; Middle Aged ; Pregnancy ; Sensory Thresholds ; Skinfold Thickness ; Smell/*physiology ; Smoking ; *Twins ; Twins, Dizygotic ; Twins, Monozygotic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 12
    facet.materialart.
    Unknown
    Transporting renal epithelium: culture in hormonally defined serum-free medium (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-11-21
    Description: A hormonally defined medium was used to isolate a homogeneous epithelioid cell population from canine kidney. Monolayers of these cells form domes, an indication of active ion transport, and this process is inhibited by ouabain. This technique allows the isolation of primary cultures of renal epithelial cells, free of fibroblasts, for the characterization of biochemical and physiological properties related to renal function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jefferson, D M -- Cobb, M H -- Gennaro, J F Jr -- Scott, W N -- New York, N.Y. -- Science. 1980 Nov 21;210(4472):912-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7434005" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport, Active ; Cell Adhesion ; Cells, Cultured ; Culture Media ; Dogs ; Epithelium/metabolism ; Female ; Kidney/*cytology ; Male ; Sodium/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 13
    facet.materialart.
    Unknown
    Dorsal root ganglion neurons are destroyed by exposure in utero to maternal antibody to nerve growth factor (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-11-21
    Description: Rats and guinea pigs, when immunized with mouse nerve growth factor, produce antibodies that cross-react with their own nerve growth factor. The antibodies reach developing offspring of these animals both prenatally (rats and guinea pigs) and postnatally (rats). Depriving the fetus of nerve growth factor in this way results in the destruction of up to 85 percent of dorsal root ganglion neurons as well as destruction of sympathetic neurons. Sensory neurons of placodal origin in the nodose ganglion were not affected. These data demonstrate that dorsal root ganglion neurons go through a phase of nerve growth factor dependence in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Johnson, E M Jr -- Gorin, P D -- Brandeis, L D -- Pearson, J -- HD12260/HD/NICHD NIH HHS/ -- HL20604/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1980 Nov 21;210(4472):916-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7192014" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibodies ; Female ; Ganglia, Spinal/cytology/*embryology/growth & development ; Guinea Pigs ; Lactation ; Maternal-Fetal Exchange ; Milk/immunology ; Nerve Growth Factors/*immunology ; Pregnancy ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 14
    facet.materialart.
    Unknown
    Maternal glucocorticoid hormones influence neurotransmitter phenotypic expression in embryos (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-31
    Description: Treatment of pregnant rats with reserpine prevented the normal disappearance of catecholamine fluorescence in presumptive neuroblasts of the embryonic gut. These cells normally express the noradrenergic phenotype transiently during embryonic development. The effect of reserpine was reproduced by treating mothers with hydrocortisone acetate. Moreover, the reserpine effect was blocked by treatment with dexamethasone, which inhibits the stress-induced increase in plasma glucocorticoids, and by mitotone, which causes adrenocortical cytolysis. It is concluded that reserpine, through the mediation of maternal glucocorticoid hormones, alters the phenotypic expression of these embryonic neuroblasts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jonakait, G M -- Bohn, M C -- Black, I B -- HD 12108/HD/NICHD NIH HHS/ -- NS 06400/NS/NINDS NIH HHS/ -- NS 10259/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1980 Oct 31;210(4469):551-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7423206" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Catecholamines/metabolism ; Female ; Hydrocortisone/*pharmacology ; Intestines/*embryology/innervation ; Maternal-Fetal Exchange ; Pregnancy ; Pregnancy, Animal/*drug effects ; Rats ; Reserpine/*pharmacology ; Sympathetic Nervous System/*embryology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 15
    facet.materialart.
    Unknown
    High-molecular-weight immunoreactive beta-endorphin in extracts of human placenta is a fragment of immunoglobulin G (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-04-11
    Description: A high-molecular-weight protein with beta-endorphin- and adrenocorticotropin-immunoreactivities was isolated from extracts of human placenta after several purification steps, including immunoadsorption with a well-characterized antiserum raised to beta-endorphin. This protein was identified as the heavy chain of the human immunoglobulin class IgG1. These results have led to the recognition of homologies in the amino acid sequences of these physiologically unrelated molecules. They also suggest caution in accepting immunological competence as the sole criterion of the chemical identity of a ligand.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Julliard, J H -- Shibasaki, T -- Ling, N -- Guillemin, R -- New York, N.Y. -- Science. 1980 Apr 11;208(4440):183-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6244620" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Electrophoresis, Polyacrylamide Gel ; Endorphins/*analysis ; Female ; Humans ; Immunoglobulin G/*analysis ; Placental Extracts/*analysis ; Pregnancy ; Radioimmunoassay ; beta-Endorphin
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 16
    facet.materialart.
    Unknown
    Allele increasing susceptibility to human breast cancer may be linked to the glutamate-pyruvate transaminase locus (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-04-25
    Description: The patterns of the occurrence of breast cancer in 11 high-risk families were evaluated by segregation and linkage analysis. These patterns were consistent with the hypothesis that increased susceptibility to breast cancer was inherited as an autosomal dominant allele with high penetrance in women. The postulated susceptibility allele in these families may be chromosomally linked to the glutamate-pyruvate transaminase (E.C. 2.6.1.2, alanine aminotransferase) locus. Confirmation of this linkage in other families would establish the existence of a gene increasing susceptibility to breast cancer. Since there is no association in the general population between a woman's glutamate-pyruvate transaminase genotype and her cancer risk, the glutamate-pyruvate transaminase linkage cannot be used as a screening test for breast cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉King, M C -- Go, R C -- Elston, R C -- Lynch, H T -- Petrakis, N L -- New York, N.Y. -- Science. 1980 Apr 25;208(4442):406-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7367867" target="_blank"〉PubMed〈/a〉
    Keywords: Alanine Transaminase/*genetics ; Alleles ; Breast Neoplasms/*genetics/transmission ; Female ; Genes ; Genetic Linkage ; Humans ; Pedigree ; X Chromosome
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 17
    facet.materialart.
    Unknown
    Testosterone-mediated sexual dimorphism of mitochondria and lysosomes in mouse kidney proximal tubules (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-29
    Description: In kidney proximal tubules of male mice the mitochondria are larger and more electron-lucent, autophagic vacuoles and lysosomes (predominantly myeloid bodies) more numerous and voluminous, and exocytosed intraluminal myeloid bodies more common than in females. Males also have higher kidney activities of mitochondrial cytochrome c oxidase and lysosomal hydrolases, and excrete larger quantities of hydrolases and protein in the urine. Orchiectomy evokes the feminine pattern whereas testosterone administration induces the male pattern. Endogenous testosterone modulates mitochondrial structure and function and enhances the activity of the lysosomal-vacuolar system in proximal tubule cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koenig, H -- Goldstone, A -- Blume, G -- Lu, C Y -- New York, N.Y. -- Science. 1980 Aug 29;209(4460):1023-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7403864" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Castration ; Enzymes/urine ; Female ; Kidney/drug effects ; Kidney Tubules, Proximal/*ultrastructure ; Lysosomes/drug effects/enzymology ; Male ; Mice ; Mitochondria/drug effects/enzymology ; Organ Size/drug effects ; Sex Differentiation/*drug effects ; Testosterone/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 18
    facet.materialart.
    Unknown
    How safe is Bendectin? (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1980 Oct 31;210(4469):518-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7423201" target="_blank"〉PubMed〈/a〉
    Keywords: Abnormalities, Drug-Induced/*etiology ; Dicyclomine ; Doxylamine/*adverse effects ; Drug Combinations/adverse effects ; Drug Evaluation ; Female ; Humans ; Jurisprudence ; Pregnancy ; Pyridines/*adverse effects ; Pyridoxine/*adverse effects ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 19
    facet.materialart.
    Unknown
    Prenatal diagnosis fo neural tube defects (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-09-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1980 Sep 12;209(4462):1216-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6157193" target="_blank"〉PubMed〈/a〉
    Keywords: Abortion, Therapeutic/standards ; Female ; Genetic Diseases, Inborn ; Government Regulation ; Great Britain ; Humans ; Neural Tube Defects/*diagnosis ; Pregnancy ; *Pregnant Women ; *Prenatal Diagnosis ; Reagent Kits, Diagnostic ; Social Justice ; Spina Bifida Occulta/diagnosis ; United States ; Voluntary Programs ; alpha-Fetoproteins/analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 20
    facet.materialart.
    Unknown
    NIH shaken by death of research volunteer (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):475-6, 478-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7394512" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Anorexia Nervosa ; Female ; *Human Experimentation ; Humans ; *Jurisprudence ; Lithium ; *National Institutes of Health (U.S.) ; *Patient Selection ; *Research ; *Research Subjects ; Sleep ; United States ; Vomiting
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 21
    facet.materialart.
    Unknown
    Tooth induction in chick epithelium: expression of quiescent genes for enamel synthesis (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-29
    Description: Intraocular grafts of chick epithelium combined with mouse molar mesenchyme produced a variety of dental structures including perfectly formed crowns with differentiated ameloblasts depositing enamel matrix. The results suggest that the loss of teeth in Aves did not result from a loss of genetic coding for enamel synthesis in the oral epithelium but from an alteration in the tissue interactions requisite for odontogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kollar, E J -- Fisher, C -- New York, N.Y. -- Science. 1980 Feb 29;207(4434):993-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7352302" target="_blank"〉PubMed〈/a〉
    Keywords: *Amelogenesis ; Animals ; Chick Embryo/*cytology ; Culture Techniques ; Dental Enamel Proteins/*biosynthesis/genetics ; Embryonic Induction ; Epithelial Cells ; Genes ; Mandible/cytology ; Mesoderm/cytology ; Mice ; *Odontogenesis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 22
    facet.materialart.
    Unknown
    Role of the spleen in the growth of a murine B cell leukemia (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-04-04
    Description: A spontaneous B cell leukemia (BCL1) grew progressively in normal BALB/c mice after injection of tumor cells but did not grow in splenectomized recipients. Despite the absence of progressive tumor growth, residual tumor cells with malignant potential were found in the peripheral blood of the splenectomized animals. Splenectomy performed after injection of tumor cells but before the development of marked leukocytosis also prevented progressive tumor growth and death of the host. Thus the spleen appears to be necessary for progressive proliferation of this lymphocytic leukemia early after passage in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kotzin, B L -- Strober, S -- New York, N.Y. -- Science. 1980 Apr 4;208(4439):59-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6965803" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes/*pathology ; Disease Models, Animal ; Female ; Leukemia, Experimental/etiology/physiopathology ; Leukemia, Lymphoid/*etiology/physiopathology ; Mice ; Mice, Inbred BALB C ; Spleen/*physiology ; Splenectomy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 23
    facet.materialart.
    Unknown
    Prolongation of islet xenograft survival without continuous immunosuppression (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-11
    Description: The survival of isolated rat islets transplanted into diabetic mice was prolonged markedly by maintaining the rat islets in vitro at 24 degrees C for 7 days before transplantation and administering to the recipients a single injection of antiserum to mouse and rat lymphocytes shortly before transplantation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lacy, P E -- Davie, J M -- Finke, E H -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):283-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6770465" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Glucose/analysis ; Cell Survival ; Cells, Cultured ; Diabetes Mellitus, Experimental/*therapy ; *Immunosuppression ; *Islets of Langerhans Transplantation ; Lymphocytes/immunology ; Male ; Mice ; Mice, Inbred BALB C ; Rats ; Transplantation, Heterologous ; Transplantation, Isogeneic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 24
    facet.materialart.
    Unknown
    Liver tumors induced in rats by oral administration of the antihistaminic methapyrilene hydrochloride (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-15
    Description: The antihistaminic over-the-counter drug methapyrilene hydrochloride, mixed with food at a concentration of 0.1 percent, was administered to 50 male and 50 female Fischer rats. A second group of 50 male and 50 female rats was given the same treatment together with 0.2 percent of sodium nitrite added to the food. Almost all of the rats in both groups developed liver neoplasms, mainly hepatocellular carcinomas and cholangiocarcinomas. The first rat died with a liver neoplasm at the 43rd week. Over 50 percent of the rats in both groups had metastases from the carcinomas of the liver to distant organs. Control rats treated with nitrite only, or untreated, did not develop liver neoplasms. There was no discernible effect of nitrite on the carcinogenicity of methapyrilene hydrochloride.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lijinsky, W -- Reuber, M D -- Blackwell, B N -- New York, N.Y. -- Science. 1980 Aug 15;209(4458):817-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7403848" target="_blank"〉PubMed〈/a〉
    Keywords: Aminopyridines/*toxicity ; Animals ; *Carcinogens ; Drug Interactions ; Female ; Liver Neoplasms, Experimental/*chemically induced/pathology ; Male ; Methapyrilene/*toxicity ; Neoplasm Metastasis ; Nitrites ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 25
    facet.materialart.
    Unknown
    Sexual dimorphism in extent of axonal sprouting in rat hippocampus (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-06-13
    Description: Sympathetic axons, normally innervating the extracerebral vasculature, sprout into denervated regions of the hippocampal formation after lesions of the medial septal nucleus or fimbria in adult female rats. Similar lesions in adult males also elicit the sympathetic ingrowth; however, the number of anomalous axons is greatly reduced and their distribution is altered. In adult males the sympathetic axons do not send out collaterals within the stratum oriens of region CA3 or the molecular layer or deep hilar regions of the area dentata, as they do in adult females. Lesions in juveniles of both sexes result in more vigorous sprouting than in their adult counterparts. In the young males the anomalous axons are distributed more extensively into the dentate molecular layer; in the young females the axons merely send out more collaterals within the same regions as in the adults. This sexually dimorphic response to central nervous system damage suggests either that the sprouting is affected by the hormonal environment of the mature hippocampal system or that this brain region, like the hypothalamus, may express permanent morphological or physiological differences as a result of exposure to sex steroids during development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Loy, R -- Milner, T A -- New York, N.Y. -- Science. 1980 Jun 13;208(4449):1282-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7375941" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Axons/growth & development ; Denervation ; Female ; Gonadal Steroid Hormones/physiology ; Hippocampus/*cytology ; Male ; Neural Pathways/cytology ; Rats ; *Sex ; Sympathetic Nervous System/*cytology/growth & development
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 26
    facet.materialart.
    Unknown
    Phenacetin safety (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Macklin, A W -- Welch, R M -- New York, N.Y. -- Science. 1980 Jan 11;207(4427):129-30, 132.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7350647" target="_blank"〉PubMed〈/a〉
    Keywords: Aminopyrine/adverse effects/toxicity ; Animals ; Humans ; Mice ; Mutagens ; Phenacetin/administration & dosage/*adverse effects/toxicity ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 27
    facet.materialart.
    Unknown
    Light suppresses melatonin secretion in humans (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-12-12
    Description: Bright artificial light suppressed nocturnal secretion of melatonin in six normal human subjects. Room light of less intensity, which is sufficient to suppress melatonin secretion in other mammals, failed to do so in humans. In contrast to the results of previous experiments in which ordinary room light was used, these findings establish that the human response to light is qualitatively similar to that of other mammals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewy, A J -- Wehr, T A -- Goodwin, F K -- Newsome, D A -- Markey, S P -- New York, N.Y. -- Science. 1980 Dec 12;210(4475):1267-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7434030" target="_blank"〉PubMed〈/a〉
    Keywords: Circadian Rhythm ; Dose-Response Relationship, Radiation ; Female ; Humans ; *Light ; Male ; Melatonin/*secretion ; Pineal Gland/secretion ; Secretory Rate
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 28
    facet.materialart.
    Unknown
    Immunoglobulin gene rearrangement in immature B cells (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-09-19
    Description: Two types of immature B cells, namely fetal liver hybridomas and the leukemic cell line 70Z/3, both of which have cytoplasmic mu chains but no light chains, were examined for DNA rearrangements of their light chain and heavy chain immunoglobulin genes. In the fetal liver hybridomas, which were constructed from fetal liver cells and a tumor cell, no light chain gene rearrangement was observed, whereas in the 70Z/3 cell line a kappa light chain rearrangement probably occurred. The results suggest that, although the lack of light chain synthesis can be due to a lack of gene rearrangement, there may also be transcriptional regulation, which may also be important for the expression of light chain immunoglobulins in immature B cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maki, R -- Kearney, J -- Paige, C -- Tonegawa, S -- New York, N.Y. -- Science. 1980 Sep 19;209(4463):1366-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6774416" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes/*immunology ; Genes ; Hybrid Cells/immunology ; Immunoglobulin Constant Regions/genetics ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin Light Chains/*genetics ; Immunoglobulin Variable Region/genetics ; Immunoglobulin kappa-Chains/*genetics ; Immunoglobulin mu-Chains/*genetics ; Leukemia, Experimental/*immunology ; Liver/*embryology ; Mice ; Recombination, Genetic ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 29
    facet.materialart.
    Unknown
    Mapping of heavy chain genes for mouse immunoglobulins M and D (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-09-19
    Description: A single DNA fragment containing both mu and delta immunoglobulin heavy chain genes has been cloned from normal BALB/c mouse liver DNA with a new lambda phage vector Charon 28. The physical distance between the membrane terminal exon of mu and the first domain of delta is 2466 base pairs, with delta on the 3' side of mu. A single transcript could contain a variable region and both mu and delta constant regions. The dual expression of immunoglobulins M and D on spleen B cells may be due to alternate splicing of this transcript.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, C P -- Tucker, P W -- Mushinski, J F -- Blattner, F R -- New York, N.Y. -- Science. 1980 Sep 19;209(4463):1348-53.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6774414" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes/immunology ; Chromosome Deletion ; *Genes ; Immunoglobulin Constant Regions/genetics ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin delta-Chains/*genetics ; Immunoglobulin mu-Chains/*genetics ; Liver/physiology ; Membrane Proteins/genetics ; Mice ; Myeloma Proteins/genetics ; Plasmids ; RNA, Messenger/genetics ; Recombination, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 30
    facet.materialart.
    Unknown
    Local effect of the blastocyst on estrogen and progesterone receptors in the rat endometrium (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-07
    Description: Nuclear receptors for both estradiol and progesterone were present in twofold higher concentrations in implantation sites than in nonimplantation regions of the endometrium of 6-day pregnant rats. Decidualization in the absence of an embryo was not accompanied by a similar increase in the concentration of nuclear receptors. Moreover, this difference in receptor distribution between the implantation and nonimplantation areas persisted when a major part of the maternal supply of sex steroids was suppressed by ovariectomy on day 5 of pregnancy. These results support the hypothesis that steroids originating from the embryo affect the endometrial implantation site.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Logeat, F -- Sartor, P -- Hai, M T -- Milgrom, E -- New York, N.Y. -- Science. 1980 Mar 7;207(4435):1083-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7355273" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blastocyst/*metabolism ; Castration ; Cell Nucleus/metabolism ; Decidua/metabolism ; Endometrium/*metabolism/ultrastructure ; Female ; Gestational Age ; Pregnancy ; Pseudopregnancy ; Rats ; Receptors, Estrogen/*metabolism ; Receptors, Progesterone/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 31
    facet.materialart.
    Unknown
    Selective inhibition of glycoprotein and membrane protein of vesicular stomatitis virus from interferon-treated cells (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-01
    Description: A 200-fold inhibition in the titer of infectious vesicular stomatitis virus (VSV) was produced in cultures of Ly cells treated with 30 reference units of interferon per milliliter. Virus particle production, as measured by VSV particle-associated transcriptase, or nucleocapsid protein was inhibited by a maximum of tenfold. The glycoprotein and membrane protein content was reduced in VSV derived from interferon-treated cells. Thus interferon-treated cells may have produced VSV particles with low infectivity, which may be related to the reduced amount of glycoprotein incorporated into such particles. These findings resemble those reported in interferon-treated cells infected with murine leukemia viruses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maheshwari, R K -- Jay, F T -- Friedman, R M -- New York, N.Y. -- Science. 1980 Feb 1;207(4430):540-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6243416" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Defective Viruses/growth & development ; Glycoproteins/*biosynthesis ; Interferons/*pharmacology ; Membrane Proteins/*biosynthesis ; Mice ; RNA, Viral/metabolism ; Vesicular stomatitis Indiana virus/*growth & development ; Viral Proteins/*biosynthesis ; Virus Replication/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 32
    facet.materialart.
    Unknown
    (-)Pentobarbital opens ion channels of long duration in cultured mouse spinal neurons (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-25
    Description: Intracellular recordings from voltage-clamped mouse spinal neurons in tissue culture were used to study the membrane mechanisms underlying inhibitory responses to gamma-aminobutyric acid and the (-) isomer of pentobarbital. Fluctuation analysis suggested that both substances activated ion channels in the membranes. However, the channels activated by pentobarbital remained open five times longer than those activated by gamma-aminobutyric acid.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mathers, D A -- Barker, J L -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):507-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6248961" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Membrane/drug effects/physiology ; Cells, Cultured ; Ion Channels/drug effects/*physiology ; Membrane Potentials/drug effects ; Mice ; Neurons/drug effects/*physiology ; Pentobarbital/*pharmacology ; Spinal Cord/*physiology ; gamma-Aminobutyric Acid/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 33
    facet.materialart.
    Unknown
    Vesicle targeting: timed release and specificity for leukocytes in mice by subcutaneous injection (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-18
    Description: When unilamellar vesicles were administered subcutaneously in mice, the half-time for the destruction of the vesicles varied from 12 to 600 hours, depending on their composition. The vesicles tested consisted of distearoyl phosphatidylcholine, cholesterol, and certain sugar and amino-sugar derivatives of cholesterol. Vesicle with amino-sugar derivatives showed the greatest longevity and became localized with high specificity in aggregates of polymorphonuclear leukocytes. A substantial delay between the time that the vesicles broke open and the time that labels contained in the vesicles were excreted suggests that the vesicles undergo endocytosis before destruction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mauk, M R -- Gamble, R C -- Baldeschwieler, J D -- New York, N.Y. -- Science. 1980 Jan 18;207(4428):309-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7350660" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cholesterol/analogs & derivatives ; Endocytosis ; Liposomes/*therapeutic use ; Lysosomes/metabolism ; Metabolic Clearance Rate ; Mice ; Neutrophils/*metabolism ; Phosphatidylcholines ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 34
    facet.materialart.
    Unknown
    Mebendazole therapy of parenteral trichinellosis (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-14
    Description: Mebendazole was highly effective against the helminth parasite Trichinella spiralis in mice subjected to a 3-day course of treatment during the invasive and encystment phases of experimental trichinellosis. When treatment began either 2 or 4 weeks after the mice were inoculated with parasites, the number of larvae developing in the host musculature was greatly reduced by twice-daily oral administration of 3.125, 6.25, or 12.5 milligrams of mebendazole per kilogram of body weight.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCracken, R O -- Taylor, D D -- New York, N.Y. -- Science. 1980 Mar 14;207(4436):1220-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7355285" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Oral ; Animals ; Benzimidazoles/*therapeutic use ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Larva ; Male ; Mebendazole/administration & dosage/*therapeutic use ; Mice ; Muscles/parasitology ; Trichinella/drug effects ; Trichinellosis/*drug therapy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 35
    facet.materialart.
    Unknown
    Gap junction development is correlated with insulin content in the pancreatic B cell (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-29
    Description: The development of gap junctions between insulin-containing B cells was quantitatively analyzed in islets of Langerhans isolated from rats treated with the sulfonylurea glibenclamid for 1, 2, or 7 days. Glibenclamid treatment was associated with a marked depletion of the insulin content of B cells and with an increase in the number and size of gap junctions between these cells. A significance correlation was found between these two events.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meda, P -- Halban, P -- Perrelet, A -- Renold, A E -- Orci, L -- New York, N.Y. -- Science. 1980 Aug 29;209(4460):1026-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6773144" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Communication/drug effects ; Female ; Freeze Fracturing ; Glyburide/*pharmacology ; Insulin/*metabolism ; Intercellular Junctions/drug effects/*ultrastructure ; Islets of Langerhans/drug effects/metabolism/*ultrastructure ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 36
    facet.materialart.
    Unknown
    The heart is a target organ for androgen (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-15
    Description: Autoradiographic and biochemical analyses of the hearts of female rhesus monkeys and baboons indicate that atrial and ventricular myocardial cells contain androgen receptors. Although the specific effects of nuclear uptake and retention of androgen on the function of heart muscle cells are not known, the presence of this receptor suggests that sex steroid hormones may affect myocardial function directly and may explain some of the peculiar differences in heart disease between men and women.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McGill, H C Jr -- Anselmo, V C -- Buchanan, J M -- Sheridan, P J -- New York, N.Y. -- Science. 1980 Feb 15;207(4432):775-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6766222" target="_blank"〉PubMed〈/a〉
    Keywords: Androgens/*metabolism ; Animals ; Coronary Disease/*etiology ; Dihydrotestosterone/metabolism ; Estradiol/metabolism ; Female ; Haplorhini ; Kinetics ; Macaca mulatta ; Myocardium/*metabolism ; Papio ; Receptors, Androgen/*metabolism ; Receptors, Steroid/*metabolism ; Sex Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 37
    facet.materialart.
    Unknown
    Insertion of a new gene of viral origin into bone marrow cells of mice (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-05-30
    Description: DNA containing the herpes simplex virus thymidine kinase (HSVtk) gene was used to transform wild-type tk+ mouse L cells to a tk++ status in vitro using methotrexate as a selective agent. HSVtk DNA was also used to transform mouse bone marrow cells in vitro. Transformed marrow cells injected into irradiated and methotrexate-treated recipient mice gave rise to proliferating cells which in some cases dominated the marrow population and which contained HSVtk gene sequences.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mercola, K E -- Stang, H D -- Browne, J -- Salser, W -- Cline, M J -- New York, N.Y. -- Science. 1980 May 30;208(4447):1033-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6246577" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Marrow/*enzymology ; Bone Marrow Transplantation ; DNA, Viral/analysis ; Drug Resistance ; *Genes, Viral ; L Cells (Cell Line) ; Methotrexate/pharmacology ; Mice ; Simplexvirus/enzymology/*genetics ; Species Specificity ; Thymidine Kinase/*genetics ; *Transformation, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 38
    facet.materialart.
    Unknown
    Evolutionary conservation of repetitive sequence expression in sea urchin egg RNA's (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-05-30
    Description: Cloned repetitive DNA sequences were used to determine the number of homologous RNA transcripts in the eggs of two sea urchin species, Strongylocentrotus purpuratus and S. franciscanus. The eggs of these species contain different amounts of RNA, and their genomes contain different numbers of copies of the cloned repeats. The specific pattern of repetitive sequence representation in the two egg RNA's is nonetheless quantitatively similar. The evolutionary conservation of this pattern suggests the functional importance of repeat sequence expression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moore, G P -- Costantini, F D -- Posakony, J W -- Davidson, E H -- Britten, R J -- New York, N.Y. -- Science. 1980 May 30;208(4447):1046-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6154974" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biological Evolution ; DNA, Recombinant ; Female ; Nucleic Acid Hybridization ; Ovum/physiology ; Plasmids ; RNA/*genetics ; Sea Urchins/*genetics ; Species Specificity ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 39
    facet.materialart.
    Unknown
    Asbestos-induced epithelial changes in organ cultures of hamster trachea: inhibition by retinyl methyl ether (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-18
    Description: The epithelium of the hamster trachea in organ culture undergoes hyperplasia and squamous metaplasia after exposure to the amphibole types of asbestos, crocidolite and amosite. These changes are inhibited when the synthetic vitamin A analog, retinyl methyl ether, is incorporated into the culture medium. These findings suggest a possible use for retinoids in the prevention and treatment of respiratory tract disease associated with environmental exposure to asbestos.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mossman, B T -- Craighead, J E -- MacPherson, B V -- New York, N.Y. -- Science. 1980 Jan 18;207(4428):311-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7350661" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Asbestos/*antagonists & inhibitors ; Cell Division/drug effects ; Cell Transformation, Neoplastic/*drug effects ; Cricetinae ; Epithelium/pathology ; Female ; Metaplasia ; Organ Culture Techniques ; Trachea/*drug effects/pathology ; Vitamin A/*analogs & derivatives/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 40
    facet.materialart.
    Unknown
    Mild cold exposure increases survival in rats with medial preoptic lesions (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-04-18
    Description: High mortality rate in rats with large medial preoptic lesions discourage their use in studies of brain function. However, virtually all such animals (six out of seven) survived indefinitely if kept at an ambient temperature of 15 degrees C for 2 hours before and 10 to 12 hours after the lesions were made. Although these rats appeared otherwise healthy, they could not maintain normal both temperatures in short-term cold tests. In contrast, five of the nine rats kept at 25 degrees C died within 10 hours after the operation, and three more died within 5 days. Rats kept at 25 degrees C had a much higher incidence of cardiac arrhythmias than did rats kept at 15 degrees C, which may be responsible for their higher moratlity rates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nagel, J A -- Satinoff, E -- New York, N.Y. -- Science. 1980 Apr 18;208(4441):301-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7367860" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Body Temperature Regulation ; Brain/physiology ; *Cold Temperature ; Female ; Heart Rate ; Hypothalamus/*physiology ; Male ; Motor Activity/physiology ; Oxygen Consumption ; Preoptic Area/*physiology/surgery ; Rats ; Vasoconstriction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 41
    facet.materialart.
    Unknown
    Asymmetry in facial expression (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nelson, C A -- Horowitz, F D -- New York, N.Y. -- Science. 1980 Aug 15;209(4458):834.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7403852" target="_blank"〉PubMed〈/a〉
    Keywords: Anthropometry ; Emotions ; *Facial Expression ; Female ; *Functional Laterality ; Humans ; Male
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 42
    facet.materialart.
    Unknown
    J genes for heavy chain immunoglobulins of mouse (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-09-05
    Description: A 15,8-kilobase pair fragment of BALB/c mouse liver DNA, cloned in the Charon 4A lambda phage vector system, was shown to contain the mu heavy chain constant region (CHmu) gene for the mouse immunoglobulin M. In addition, this fragment of DNA contains at least two J genes, used to code for the carboxyl terminal portion of heavy chain variable regions. These genes are located in genomic DNA about eight kilobase pairs to the 5' side of the CHmu gene. The complete nucleotide sequence of a 1120-base pair stretch of DNA that includes the two J genes has been determined.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Newell, N -- Richards, J E -- Tucker, P W -- Blattner, F R -- New York, N.Y. -- Science. 1980 Sep 5;209(4461):1128-32.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6250219" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Binding Sites, Antibody/*genetics ; DNA Restriction Enzymes ; DNA, Recombinant ; Genes ; Genetic Linkage ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin Variable Region/*genetics ; Immunoglobulin mu-Chains/*genetics ; Mice
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 43
    facet.materialart.
    Unknown
    Ethanol specifically potentiates GABA-mediated neurotransmission in feline cerebral cortex (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-08
    Description: Ethanol (ethyl alcohol) potentiates the inhibition of cortical neurons by gamma-aminobutyric acid. This effect is specific, since ethanol does not potentiate inhibiton by glycine, serotonin, or dopamine. These results have implications for alcoholism because (i) gamma-aminobutyric acid mediates anxiolytic mechanisms, and (ii) anxiety is implicated in the etiology of alcoholism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nestoros, J N -- New York, N.Y. -- Science. 1980 Aug 8;209(4457):708-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7394531" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Cerebral Cortex/drug effects/*physiology ; Drug Synergism ; Electric Conductivity ; Electric Stimulation ; Ethanol/*pharmacology ; Female ; Male ; Neurons/drug effects/*physiology ; Serotonin/pharmacology ; gamma-Aminobutyric Acid/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 44
    facet.materialart.
    Unknown
    Gene affecting superoxide dismutase activity linked to the histocompatibility complex in H-2 congenic mice (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-04
    Description: The activity of cyanide-sensitive, Cu-Zn superoxide dismutase (SOD) was studied in liver sytosols from H-2 congenic strains of mice. Higher SOD activity was found in livers of mice having H-2b/A.BY, B10, and C3H.SW/haplotypes than in those of H-2a, H-2k and H-2d haplotypes. Segregation studies supported these correlations. In H-2 recombinant strains of mice, the genes influencing the liver SOD activity occur, as ascertained by mapping techniques, at or near the H-2d region of the major histocompatibility complex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Novak, R -- Bosze, Z -- Matkovics, B -- Fachet, J -- New York, N.Y. -- Science. 1980 Jan 4;207(4426):86-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7350646" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Genes ; Genes, Regulator ; Genetic Linkage ; H-2 Antigens/*genetics ; Liver/enzymology ; *Major Histocompatibility Complex ; Mice ; Superoxide Dismutase/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 45
    facet.materialart.
    Unknown
    Substance P: does it produce analgesia or hyperalgesia? (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-04-18
    Description: In the hot plate test, substance P given intravenously at doses of 5 x 10-5 and 5 x 10-4 gram per kilogram caused analgesia, while lower doses caused hyperalgesia. The influence of substance P on nociception depended on the individual mouse's sensitivity to pain (control response latency). Analgesia was produced by substance P administered to mice with high sensitivity to thermic stimulation, whereas hyperalgesia occurred in mice whose control latencies were longer than normal. This result is interpreted as an indication that substance P is capable of normalizing responsiveness to pain and could be classified as a regulatory peptide.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Oehme, P -- Hilse, H -- Morgenstern, E -- Gores, E -- New York, N.Y. -- Science. 1980 Apr 18;208(4441):305-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6154313" target="_blank"〉PubMed〈/a〉
    Keywords: Acetates ; Animals ; Dose-Response Relationship, Drug ; Hot Temperature ; Hyperalgesia/*chemically induced ; Hyperesthesia/*chemically induced ; Mice ; Nociceptors/drug effects ; Pain/*physiopathology ; Perception/*drug effects ; Receptors, Drug/physiology ; Substance P/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 46
    facet.materialart.
    Unknown
    Calcium regulation during stimulus-secretion coupling: continuous measurement of intracellular calcium activities (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-25
    Description: Accurate measurements of intracellular calcium activities in salivary gland epithelial cells of the insect Phormia regina were obtained with microelectrodes in which N,N'-di(11-ethoxycarbonyl)undecyl-N,N'-4,5-tetramethyl-3,6-dioxaoctane diacid diamide wsa incorporated in a liquid membrane system. When calibrated in solutions approximating the ionic concentration of the cell interior, these microelectrodes gave rapid stable responses that were linear functions of the logarithm of calcium activities and were not affected by potassium, sodium and magnesium. Continuous monitoring of calcium activities during serotonin-induced saliva release provided direct evidence of hormonal influence on transmembrane calcium movement and spontaneous regulation of intracellular calcium by stimulated cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Doherty, J -- Youmans, S J -- Armstrong, W M -- Stark, R J -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):510-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7394518" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport/drug effects ; Calcium/*metabolism ; Diptera/*metabolism ; Epithelium/metabolism ; Kinetics ; Magnesium/pharmacology ; Microelectrodes ; Salivary Glands/drug effects/*metabolism ; Serotonin/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 47
    facet.materialart.
    Unknown
    Human monoclonal antibody against Forssman antigen (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-31
    Description: Hybrid cells formed between human lymphocytes and mouse myeloma cells produce human immunoglobulin in culture. Stable antibody-producing cell lines can be isolated after multiple cycles of low-density passage, cloning, and continued selection for immunoglobulin production. The origin and characteristics of a hybrid of human and mouse cells is described. This hybrid produces high concentrations (8.3 micrograms per milliliter) of human immunoglobulin M reactive with the terminal disaccharide of the Forssman glycolipid. These findings point to the potential use of human-mouse hybrid cells as a source of human monoclonal antibodies for therapeutic and diagnostic purposes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nowinski, R -- Berglund, C -- Lane, J -- Lostrom, M -- Bernstein, I -- Young, W -- Hakomori, S I -- Hill, L -- Cooney, M -- New York, N.Y. -- Science. 1980 Oct 31;210(4469):537-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7423202" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibodies ; Antibody Formation ; Antibody Specificity ; Cells, Cultured ; Clone Cells/immunology ; *Forssman Antigen ; Humans ; Hybrid Cells/immunology ; Immunoglobulin M/biosynthesis ; Mice
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 48
    facet.materialart.
    Unknown
    alpha-Lactalbumin-casein induction in virgin mouse mammary explants: dose-dependent differential action of cortisol (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-21
    Description: The interplay of insulin, cortisol, and prolactin induces synthesis of casein and alpha-lactalbumin in cultured mammary explants from mature virgin mice. A striking difference has been found between the optimal concentrations of cortisol required for maximal induction of the two milk proteins in vitro: 3 x 10(-8) molar for alpha-lactalbumin and 3 x 10(-6) molar for casein. Moreover, 10(-7) to 10(-5) molar cortisol caused progressive inhibition of alpha-lactalbumin accumulation. Such differential actions of cortisol may partly account for the asynchronous synthesis of the two proteins during pregnancy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ono, M -- Oka, T -- New York, N.Y. -- Science. 1980 Mar 21;207(4437):1367-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6986657" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Caseins/*biosynthesis ; Dose-Response Relationship, Drug ; Drug Interactions ; Female ; Hydrocortisone/*pharmacology ; Insulin/pharmacology ; Lactalbumin/*biosynthesis ; Mammary Glands, Animal/drug effects/*metabolism ; Mice ; Organ Culture Techniques ; Pregnancy ; Prolactin/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 49
    facet.materialart.
    Unknown
    Properties of a normal mouse cell DNA sequence (sarc) homologous to the src sequence of Moloney sarcoma virus (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-14
    Description: A 15.0-kilobase (kb) Eco RI DNA fragment from normal mouse Balb/c genomic DNA that contains sequences (sarc) homologous to the acquired cell sequences (src) of Moloney sarcoma virus (MSV) has been cloned in phage lambda. The sarc region (1.2 to 1.3 kb) of the 15.0-kb cell fragment is indistinguishable from the src region of two isolates of MSV as judged by heteroduplex and restriction endonuclease analyses. The cellular sequences flanking sarc show no homology to other MSV sequences. Whereas cloned subgenomic portions of MSV that contain src transformed NIH-3T3 cells in vitro, the cloned sarc fragment is inactive.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Oskarsson, M -- McClements, W L -- Blair, D G -- Maizel, J V -- Vande Woude, G F -- New York, N.Y. -- Science. 1980 Mar 14;207(4436):1222-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6243788" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Chromosome Mapping ; DNA Restriction Enzymes ; *Genes ; *Genes, Viral ; Mice ; Mice, Inbred BALB C/*genetics ; Moloney murine leukemia virus/*genetics ; Nucleic Acid Hybridization
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 50
    facet.materialart.
    Unknown
    Cytosolic and microsomal epoxide hydrolases: differential properties in mammalian liver (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-28
    Description: The epoxide hydrolase activities of the 100,000 g pellet (microsomal) and 100,00 g soluble (cystosolic) fractions of mouse, rat, and guinea pig liver were measured with three closely related compounds used as substrates. Differences between the species in the distribution of the cytosolic and microsomal hydrolases and in their substrate specificities and pH optima demonstrate why epoxide hydrolase activity in the cytosolic fraction was not detected earlier in spie of intensive work on the microsomal epoxide hydrolase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ota, K -- Hammock, B D -- New York, N.Y. -- Science. 1980 Mar 28;207(4438):1479-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7361100" target="_blank"〉PubMed〈/a〉
    Keywords: Allyl Compounds ; Animals ; Benzene ; Cytosol/enzymology ; Epoxide Hydrolases/*metabolism ; Guinea Pigs ; Hydrogen-Ion Concentration ; Liver/*enzymology/ultrastructure ; Mice ; Microsomes, Liver/enzymology ; Rats ; Styrenes ; Substrate Specificity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 51
    facet.materialart.
    Unknown
    Genes for growth hormone, chorionic somatommammotropin, and growth hormones-like gene on chromosome 17 in humans (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-11
    Description: The human genes for growth hormone (GH), chorionic somatomammotropin (CSH), and a third growth hormone-like gene (GHL) have been located on chromosome 17 in humans. DNA fragments of 2.6, 2.8, and 9.5 kilobase pairs containing GH, CSH, and GHL, respectively, were identified in human genomic DNA, and a 7.5-kilobase DNA fragment related to growth hormone DNA sequences was found in mouse cells. In somatic hybrids of human and mouse cells containing reduced numbers of human chromosomes, but a normal complement of mouse chromosomes, the mouse, 7.5-kolobase DNA fragment was always present, whereas the 2.6-, 2.8-, and 9.5-kilobase human fragments were present only when human chromosome 17 was also present.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Owerbach, D -- Rutter, W J -- Martial, J A -- Baxter, J D -- Shows, T B -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):289-92.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7384802" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cell Line ; *Chromosomes, Human, 16-18 ; *DNA/metabolism ; *Genes ; Growth Hormone/*biosynthesis ; Humans ; Hybrid Cells/metabolism ; Mice ; Placental Lactogen/*biosynthesis ; Translocation, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 52
    facet.materialart.
    Unknown
    Inverse relation between low-density lipoprotein-cholesterol and dehydroisoandrosterone sulfate in human fetal plasma (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-05-02
    Description: A striking inverse correlation was found in umbilical cord plasma between the concentrations of dehydroisoandrosterone sulfate and low-density lipoprotein (LDL)-cholesterol but not high-density lipoprotein-cholesterol or very low density lipoprotein-cholesterol. Dehydroisoandrosterone sulfate is a major secretory product of the human fetal adrenal and the principal precursor of placental estrogen production. The data suggest that the concentrations for LDL-cholesterol in fetal plasma are influenced by the rate of utilization of LDL-cholesterol by the fetal adrenal for steroidogenesis and are not necessarily related to a genetic predisposition for hypercholesterolemia or other lipoprotein disorders.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Parker, C R Jr -- Simpson, E R -- Bilheimer, D W -- Leveno, K -- Carr, B R -- MacDonald, P C -- New York, N.Y. -- Science. 1980 May 2;208(4443):512-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6445079" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Cortex/metabolism ; Adrenal Cortex Hormones/secretion ; Cholesterol/*blood ; Dehydroepiandrosterone/*analogs & derivatives/blood/metabolism ; Dehydroepiandrosterone Sulfate ; Female ; Fetal Blood/*analysis ; Humans ; Hypertension/metabolism ; Lipoproteins, LDL/*blood/metabolism ; Maternal-Fetal Exchange ; Pregnancy ; Pregnancy Complications, Cardiovascular/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 53
    facet.materialart.
    Unknown
    Opiate analgesia: evidence for mediation by a subpopulation of opiate receptors (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-05-02
    Description: Naloxazone, a hydrazone derivative of the opiate antagonist naloxone, has a high affinity for opiate receptor binding sites. Naloxazone injections reduce opiate receptor binding to extensively washed mouse brain membranes for more than 24 hours, suggesting that the effect is irreversible. High-affinity binding sites are abolished by this treatment, whereas low-affinity sites are unaffected. Naloxazone treatment blocks the analgesic effects of morphine for at least 24 hours but does not prevent death from high doses of morphine. Thus analgesic but nonlethal opiate effects may be mediated by the high-affinity subpopulation of opiate receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pasternak, G W -- Childers, S R -- Snyder, S H -- New York, N.Y. -- Science. 1980 May 2;208(4443):514-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6245448" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding Sites/drug effects ; Brain/metabolism ; Mice ; Morphine/pharmacology/toxicity ; Naloxone/adverse effects/*analogs & derivatives/pharmacology ; Receptors, Opioid/classification/*drug effects/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 54
    facet.materialart.
    Unknown
    Pro-adrenocorticotropin/endorphin-derived peptides: coordinate action on adrenal steroidogenesis (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-05-30
    Description: A synthetic peptide, representing a portion of the 16K (16,000 dalton)-fragment sequence within the pro-adrenocorticotropin/endorphin precursor molecule, potentiates the steroidogenic action of the 1 to 24 portion of adrenocorticotropin [ACTH(1-24)] on the rat adrenal cortex. The peptide has 27 amino acid residues and consists of gamma-melanotropin with a carboxyl terminal extension. It affects both the inner and outer adrenocortical zones of hypophysectomized animals, as evidenced by a synergistic augmentation of corticosterone and aldosterone production, respectively. The peptide can be distinguished from adrenocorticotropin by its activation of cholesterol ester hydrolase and its failure to stimulate cholesterol side-chain cleavage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pedersen, R C -- Brownie, A C -- Ling, N -- New York, N.Y. -- Science. 1980 May 30;208(4447):1044-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6246578" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Cortex/*drug effects/metabolism ; Adrenal Cortex Hormones/*biosynthesis ; Adrenocorticotropic Hormone/*pharmacology ; Aldosterone/biosynthesis ; Animals ; Corticosterone/biosynthesis ; Endorphins/pharmacology ; Female ; Melanocyte-Stimulating Hormones/*pharmacology ; Molecular Weight ; Peptide Fragments/*pharmacology ; Protein Precursors/pharmacology ; Rats ; Sterol Esterase/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 55
    facet.materialart.
    Unknown
    Lithium reduces the number of acetylcholine receptors in skeletal muscle (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-17
    Description: Extended treatment of rats with lithium inhibits the increase in the number of extrajunctional acetylcholine receptors that occurs in their denervated skeletal muscle. In normal muscle, lithium reduces the number of acetylcholine receptors at neuromuscular junctions. These changes appear to be a relatively specific effect of lithium on the turnover of receptors. Skeletal muscle provides an accessible system for analyzing the role of lithium (and other cations) in the regulation of cell surface receptors. This regulation may play a role in the mechanism by which lithium prevents recurrent manic-depressive episodes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pestronk, A -- Drachman, D B -- 5P01-NS10920/NS/NINDS NIH HHS/ -- 5R01-HD04817/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1980 Oct 17;210(4467):342-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7423198" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/metabolism ; Animals ; Female ; Lithium/*pharmacology ; Muscle Denervation ; Muscles/*drug effects/metabolism ; Neuromuscular Junction/drug effects ; Rats ; Receptors, Cholinergic/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 56
    facet.materialart.
    Unknown
    Sperm-egg interaction: evidence for boar sperm plasma membrane receptors for porcine zona pellucida (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-04
    Description: Freshly ejaculated, noncapacitated boar sperm bind rapidly and in large numbers to pig egg zona pellucida in vitro. In the present study, the number of sperm bound decreased sharply when sperm motility was lowered by energy poisons or by reducing the temperature. Highly motile sperm from humans, guinea pigs, and rats, added at concentrations ten times higher than control sperm, did not bind to the porcine zona. At the same high concentration, a small number of hamster and bull sperm bound to the zona. Binding of boar sperm to the zona pellucida was blocked almost completely by diluted whole antiserum to sperm plasma membranes and by univalent (Fab) antibody to these membranes. When antibody to sperm plasma membrane was first absorbed with plasma membrane vesicles, sperm binding was not inhibited. These results provide direct evidence for the existence of sperm plasma membrane receptors for the zona pellucida of the pig.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peterson, R N -- Russell, L -- Bundman, D -- Freund, M -- New York, N.Y. -- Science. 1980 Jan 4;207(4426):73-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7188647" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cattle ; Cell Membrane/metabolism ; Female ; *Fertilization ; Guinea Pigs ; Humans ; Immunoglobulin Fab Fragments ; Male ; Ovum/*metabolism ; Rats ; Receptors, Drug/metabolism ; Species Specificity ; *Sperm-Ovum Interactions ; Spermatozoa/*metabolism ; Swine ; Zona Pellucida/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 57
    facet.materialart.
    Unknown
    Nerve terminals are as metabolically different as the muscle fibers they innervate (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-11-21
    Description: The rate at which glucose enters nerve terminals in muscle was estimated indirectly by measuring changes in miniature end-plate potential frequency D-Glucose entered nerve terminals in muscles with a fast twitch more rapidly than it entered those with a slow twitch. This suggests that nerve terminals in fast- and slow-twitch muscles differ in their rate of metabolism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pickett, J B -- New York, N.Y. -- Science. 1980 Nov 21;210(4472):927-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7434009" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport ; Diaphragm/innervation ; Glucose/*metabolism ; Kinetics ; Membrane Potentials ; Nerve Endings/*metabolism ; Neuromuscular Junction/*metabolism ; Osmolar Concentration ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 58
    facet.materialart.
    Unknown
    Blood lead concentrations in a remote Himalayan population (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-12-05
    Description: The lead content in the air at the foothills of the Himalayas in Nepal was found to be negligible. The concentration of lead in the blood of 103 children and adults living in this region was found to average 3.4 micrograms per deciliter, a level substantially lower than that found in industrialized populations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Piomelli, S -- Corash, L -- Corash, M B -- Seaman, C -- Mushak, P -- Glover, B -- Padgett, R -- ES-01104/ES/NIEHS NIH HHS/ -- ES-26437/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 1980 Dec 5;210(4474):1135-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7444442" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Air Pollutants/*analysis ; Child, Preschool ; China ; Environment ; Female ; Humans ; *Industry ; Lead/*blood ; Male ; Nepal
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 59
    facet.materialart.
    Unknown
    Estrogen and the growth of breast cancer: new evidence suggests indirect action (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-08
    Description: The growth of the MCF-7 human breast cancer cell line is unresponsive to the presence of estrogen in culture media. Paradoxically, in nude mice, growth of these cells and formation of solid tumors are dependent on estrogen. Tumors fail to develop in ovariectomized mice, but do develop in intact mice and in ovariectomized mice given estrogen. Primary cultures derived from MCF-7 tumors revert to unresponsiveness to estrogen. However, when these cultures are again transplanted into nude mice, estrogen is required for tumor formation. The continuous culture, the solid tumor, and the primary cultures therefrom have similar estrogen-binding capacities and affinities. These results indicate that mammary carcinoma cell growth in vivo is subject to inhibition that can be overcome by estrogen.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shafie, S M -- New York, N.Y. -- Science. 1980 Aug 8;209(4457):701-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6994231" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Breast Neoplasms/metabolism/*physiopathology ; Castration ; Cell Division/drug effects ; Cell Line ; Cytosol/metabolism ; Estradiol/metabolism/*pharmacology ; Female ; Humans ; Insulin/pharmacology ; Mice ; Mice, Nude ; Neoplasm Transplantation ; Receptors, Estrogen/metabolism ; Transplantation, Heterologous
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 60
    facet.materialart.
    Unknown
    Correction of enzyme deficiency in mice by allogeneic bone marrow transplantation with total lymphoid irradiation (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-12-05
    Description: Enzyme deficiency was corrected in mice after allogeneic bone marrow transplantation with occurrence of graft versus host disease. beta-Glucuronidase-deficient C3H/HeJ mice were treated with total lymphoid irradiation. Normal bone marrow cells (30 X 10(6)) from BALB/c to C3H/HeJ chimeras (〉90 percent circulating donor-type cells) without graft versus host disease. beta-Glucuronidase activity increases to normal levels in all chimeras as measured in the liver and in the plasma. Activity was maintained throughout an observation period of 7 months.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slavin, S -- Yatziv, S -- A1 15387/PHS HHS/ -- New York, N.Y. -- Science. 1980 Dec 5;210(4474):1150-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7003711" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Bone Marrow Transplantation ; Glucuronidase/blood/*deficiency ; Liver/enzymology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C3H ; Radiation Chimera ; Transplantation, Homologous
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 61
    facet.materialart.
    Unknown
    Food dyes impair performance of hyperactive children on a laboratory learning test (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-28
    Description: Forty children were given a diet free of artificial food dyes and other additives for 5 days. Twenty of the children had been classified as hyperactive by scores on the Conners Rating Scale and were reported to have favorable responses to stimulant medication. A diagnosis of hyperactivity had been rejected in the other 20 children. Oral challenges with large doses (100 or 150 milligrams) of a blend of FD & C approved food dyes or placebo were administered on days 4 and 5 of the experiment. The performance of the hyperactive children on paired-associate learning tests on the day they received the dye blend was impaired relative to their performance after they received the placebo, but the performance of the nonhyperactive group was not affected by the challenge with the food dye blend.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Swanson, J M -- Kinsbourne, M -- New York, N.Y. -- Science. 1980 Mar 28;207(4438):1485-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7361102" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; Dose-Response Relationship, Drug ; Female ; Food Coloring Agents/*pharmacology ; Humans ; Hyperkinesis/*physiopathology ; Learning/*drug effects ; Male ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 62
    facet.materialart.
    Unknown
    Regional assignment of genes for human esterase D and retinoblastoma to chromosome band 13q14 (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-05-30
    Description: The expression of human esterase D was evaluated quantitatively and qualitatively in five persons with partial deletions or duplications of chromosome 13. The results showed that the locus of this enzyme is at band 13q14. Deletion of this same band in other subjects has been found previously to indicate a predisposition to the development of retinoblastoma, which was present in the four individuals in this study who had partial deletions of chromosome 13. Because of this close synteny, esterase D evaluation should aid in the diagnosis and genetic counseling of retinoblastoma.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sparkes, R S -- Sparkes, M C -- Wilson, M G -- Towner, J W -- Benedict, W -- Murphree, A L -- Yunis, J J -- New York, N.Y. -- Science. 1980 May 30;208(4447):1042-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7375916" target="_blank"〉PubMed〈/a〉
    Keywords: Chromosome Deletion ; Chromosome Mapping ; *Chromosomes, Human, 13-15 ; Esterases/*genetics ; Female ; Genes ; Humans ; Intellectual Disability/enzymology/genetics ; Male ; Retinoblastoma/enzymology/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 63
    facet.materialart.
    Unknown
    Neurobiology of amnesia (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Squire, L R -- Davis, H P -- Spanis, C W -- New York, N.Y. -- Science. 1980 Aug 15;209(4458):836-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7190729" target="_blank"〉PubMed〈/a〉
    Keywords: Amnesia/*physiopathology ; Amnesia, Retrograde/*physiopathology ; Animals ; Brain Chemistry ; Catecholamines/metabolism ; Cycloheximide/pharmacology ; Humans ; Memory/drug effects ; Mice ; Nerve Tissue Proteins/biosynthesis ; Phenoxybenzamine/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 64
    facet.materialart.
    Unknown
    Pituitary gonadotropin-releasing hormone receptors during the rat estrous cycle (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-22
    Description: The binding of [6-alanine]gonadotropin-releasing hormone to pituitary plasma membranes increased threefold between metestrus and early proestrus in female rats. Receptor numbers fell rapidly on the afternoon of proestrus coincident with the preovulatory gonadotropin surge. The numbers of receptors for gonadotropin-releasing hormone were positively correlated with concentrations of estradiol in serum; this pattern may be a necessary component of increased pituitary sensitivty to gonadotropin-releasing hormone observed during proestrus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Savoy-Moore, R T -- Schwartz, N B -- Duncan, J A -- Marshall, J C -- New York, N.Y. -- Science. 1980 Aug 22;209(4459):942-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6250218" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Membrane/metabolism ; Estradiol/blood ; *Estrus ; Feedback ; Female ; Follicle Stimulating Hormone/blood ; Gonadotropin-Releasing Hormone/analogs & derivatives/*metabolism ; Kinetics ; Luteinizing Hormone/blood ; Pituitary Gland, Anterior/*metabolism ; Pregnancy ; Progesterone/blood ; Rats ; Receptors, Cell Surface/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 65
    facet.materialart.
    Unknown
    Glucan-induced modification of murine viral hepatitis (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-04-04
    Description: Glucan, a macrophage stimulant, was evaluated for its ability to alter survival and phagocytic dysfunction in mice challenged with mouse hepatitis virus strain MHV-A59. Administration of glucan before the mice were challenged with the virus significantly prolonged median survival time but did not modify overall mortality compared with control mice given dextrose. Maximal effectiveness was achieved when glucan was administered both before and after the viral challenge. In contrast to the marked hepatic parenchymal cell necrosis observed in the control mice, glucan-treated mice exhibited reduced pathology. Intraperitoneal administration of MHV-A59 resulted in a significant depression of phagocytic activity compared with controls that were not exposed to the virus. The enhancement in phagocytic function in glucan-treated control mice was unaltered in virus-challenged, glucan-treated mice. Thus glucan is capable of increasing survival, inhibiting hepatic necrosis, and maintaining an activated state of phagocytic activity in mice challenged with MHV-A59. Macrophage stimulants may have a significant role in the modification of virally induced hepatic lesions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Williams, D L -- Di Luzio, N R -- New York, N.Y. -- Science. 1980 Apr 4;208(4439):67-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7361108" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Glucans/*pharmacology/therapeutic use ; Hepatitis, Viral, Animal/drug therapy/*immunology/mortality ; Liver/pathology ; Macrophages/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Phagocytosis/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 66
    facet.materialart.
    Unknown
    Rate of acoustic change may underlie hemispheric specialization for speech perception (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-21
    Description: Phonemically similar syllables, differing only by temporal acoustic cues, were presented dichotically to investigate temporal processing mechanisms in hemispheric specialization for speech. Reducing the rate of acoustic change within syllables while keeping their phonemic characteristics constant significantly decreased the characteristic asymmetry in processing speech.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwartz, J -- Tallal, P -- New York, N.Y. -- Science. 1980 Mar 21;207(4437):1380-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7355297" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Auditory Pathways/physiology ; Auditory Perception/*physiology ; Brain/*physiology ; Female ; *Functional Laterality ; Humans ; Linguistics ; Male ; Speech Perception/*physiology ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 67
    facet.materialart.
    Unknown
    Latency of herpes simplex virus in absence of neutralizing antibody: model for reactivation (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-11-28
    Description: Mice inoculated with herpes simplex virus (type 1) by the lip or corneal route and then passively immunized with rabbit antibody to herpes simplex virus developed a latent infection in the trigeminal ganglia within 96 hours. Neutralizing antibody to herpes simplex virus was cleared from the circulation and could not be detected in most of these mice after 2 months. Examination of ganglia from the antibody-negative mice revealed latent virus in over 90 percent of the animals, indicating that serum neutralizing antibody is not necessary to maintain the latent state. When the lips or corneas of these mice were traumatized, viral reactivation occurred in up to 90 percent of the mice, as demonstrated by the appearance of neutralizing antibody. This study provides a model for identifying factors that trigger viral reactivation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sekizawa, T -- Openshaw, H -- Wohlenberg, C -- Notkins, A L -- New York, N.Y. -- Science. 1980 Nov 28;210(4473):1026-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6254149" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Viral/*metabolism ; Antigens, Viral/analysis ; Disease Models, Animal ; Ganglia/microbiology ; Herpes Simplex/*immunology ; Immune Tolerance ; Immunization, Passive ; Mice ; Simplexvirus/*growth & development/immunology ; *Virus Activation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 68
    facet.materialart.
    Unknown
    Health survey in high background radiation areas in China: High Background Radiation Research Group, China (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1980 Aug 22;209(4459):877-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7403855" target="_blank"〉PubMed〈/a〉
    Keywords: Abortion, Spontaneous/etiology ; China ; *Chromosome Aberrations ; Dose-Response Relationship, Radiation ; *Environmental Exposure ; Female ; Genetic Diseases, Inborn/*etiology ; Growth/radiation effects ; Humans ; *Maximum Allowable Concentration ; Neoplasms, Radiation-Induced/epidemiology/etiology ; Pregnancy ; *Radiation, Ionizing
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 69
    facet.materialart.
    Unknown
    Hemoglobin switching: a cellular model (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-08
    Description: Regulation of hemoglobin synthesis depends in part on the population of cells available for erythroid differentiation. Mouse erythroleukemia cells were cloned, and the clones were induced with dimethyl sulfoxide to test the relative induction of beta minor and beta major synthesis. Cells of line 745 produced approximately 35 percent beta minor after induction, and 39 clones of line 745 produced from 23 to 61 percent beta minor. Further subcloning of the clone that produced 61 percent beta minor led to three subclones, all of which produced more than 90 percent beta minor. Thus one kind of hemoglobin regulation occurs at the cellular level.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alter, B P -- Goff, S C -- New York, N.Y. -- Science. 1980 Feb 8;207(4431):647-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6928071" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; Cell Line ; Clone Cells/metabolism ; Dimethyl Sulfoxide/pharmacology ; Globins/*biosynthesis/genetics ; Leukemia, Erythroblastic, Acute/metabolism ; Mice
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 70
    facet.materialart.
    Unknown
    Histone gene expression: progeny of isolated early blastomeres in culture make the same change as in the embryo (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-01
    Description: Stage-specific changes in histone synthesis during sea urchin development reflect the expression of different sets of genes. The three kinds of blastomeres formed at the 16-cell stage are the earliest "determined" cells and fall into three distinct size classes. At this stage that cells synthesize only "early" histones. Such blastomeres can survive and divide in culture after being separated from the embryo, whether or not they are permitted to aggregate. With or without reaggregation, cultured progeny cells of each type of isolated blastomere perform the same changeover of histone synthesis as takes place in the intact embryo, that is, they begin spontaneously to synthesize a new set, the "late" histone variants. Normal contact relations among cells of the embryo are, therefore, not required for this programmed change in gene expression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arceci, R J -- Gross, P R -- New York, N.Y. -- Science. 1980 Aug 1;209(4456):607-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7394523" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blastomeres/*metabolism ; Cells, Cultured ; DNA/metabolism ; DNA, Superhelical/metabolism ; Embryo, Nonmammalian/*metabolism ; Female ; *Genes ; Histones/*biosynthesis ; Nucleosomes/metabolism ; *Protein Biosynthesis ; Sea Urchins ; *Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 71
    facet.materialart.
    Unknown
    The fetal sound environment of sheep (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-06-06
    Description: Hydrophones implanted inside the intact amniotic sac recorded sounds available to fetal lambs. Unlike recordings made from outside the intact amnion in human subjects, sounds produced at levels similar to normal conversation from outside the ewe were picked up without masking by maternal cardiovascular sounds. Noises from inside the mother were intermittent and linked to her activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Armitage, S E -- Baldwin, B A -- Vince, M A -- New York, N.Y. -- Science. 1980 Jun 6;208(4448):1173-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7375927" target="_blank"〉PubMed〈/a〉
    Keywords: Amnion/physiology ; Animals ; Audiometry/methods ; Cardiovascular Physiological Phenomena ; Environment ; Female ; Sheep/*embryology ; *Sound
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 72
    facet.materialart.
    Unknown
    Neurotransmitter release from a vertebrate neuromuscular synapse affected by a food dye (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-28
    Description: The food dye erythrosine (Erythrosin B; FD & C No. 3) was applied to isolated neuromuscular synapses in the frog, and its effects on the spontaneous quantal release of acetylcholine were examined with electrophysiological techniques. At concentrations of 10 muM or greater this anionic dye produced an irreversible, dose-dependent increase in neurotransmitter release. This increase did not depend on the presence of calcium ions in the bathing medium. These increase did not depend on the presence of calcium ions in the bathing medium. These results suggest that erythrosine might prove a useful pharmacological tool for studying the process of transmitter release, but that its use as a food additive should be reexamined.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Augustine, G J Jr -- Levitan, H -- New York, N.Y. -- Science. 1980 Mar 28;207(4438):1489-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6244619" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anura ; Calcium/physiology ; Erythrosine/*pharmacology ; Fluoresceins/*pharmacology ; Kinetics ; Membrane Potentials/drug effects ; Motor Endplate/drug effects ; Neuromuscular Junction/*drug effects ; Rana pipiens ; Stimulation, Chemical ; Synaptic Transmission/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 73
    facet.materialart.
    Unknown
    Polyamine metabolism: a potential therapeutic target in trypanosomes (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-17
    Description: alpha-Difluoromethylornithine (RMI 71,782), a specific irreversible inhibitor of the first step in polyamine biosynthesis, that is, the formation of putrescine from ornithine by ornithine decarboxylase, cures mice infected with a virulent, rodent-passaged strain of Trypanosoma brucei brucei. This parasite is closely related to the trypanosomes that cause human sleeping sickness. The drug, which is remarkably nontoxic, was effective when administered in drinking water or by intubation. The ability of the compound to inhibit ornithine decarboxylase in vitro was demonstrated by the reduced amounts of putrescine synthesized from tritiated ornithine in Trypanosoma brucei suspensions. These observations direct attention to polyamine metabolism as a target for chemotherapy of parasitic diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bacchi, C J -- Nathan, H C -- Hutner, S H -- McCann, P P -- Sjoerdsma, A -- AI 13801/AI/NIAID NIH HHS/ -- AI 13852/AI/NIAID NIH HHS/ -- FR-05596/PHS HHS/ -- New York, N.Y. -- Science. 1980 Oct 17;210(4467):332-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6775372" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Eflornithine ; Mice ; Ornithine/analogs & derivatives/metabolism/pharmacology ; Ornithine Decarboxylase Inhibitors ; Polyamines/*metabolism ; *Trypanocidal Agents ; Trypanosoma brucei brucei/drug effects/metabolism ; Trypanosomiasis, African/*drug therapy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 74
    facet.materialart.
    Unknown
    Goal orientation by blindfolded humans after long-distance displacement: possible involvement of a magnetic sense (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-31
    Description: A wide range of animals are able to orient toward home when subjected to displacement-release experiments. When comparable experiments are performed on blindfolded humans, a similar ability emerges. Such goal-orientation does not result from following the complete journey on a mental map, nor is it influenced by cloud cover. Bar magnets worn on the head do seem to exert an influence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baker, R R -- New York, N.Y. -- Science. 1980 Oct 31;210(4469):555-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7423208" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Female ; Humans ; Magnetics ; Male ; Orientation/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 75
    facet.materialart.
    Unknown
    Picrotoxin convulsions involve synaptic and nonsynaptic mechanisms on cultured mouse spinal neurons (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-05-30
    Description: The cellular mechanisms underlying picrotoxin-induced convulsive activity were studied by using mouse spinal neurons growing in tissue culture. Picrotoxin-induced convulsive activity in most but not all of the cells studied. The activity could be inverted by polarizing to positive potentials and eliminated either by decreasing the ratio of calcium to magnesium or by applying tetrodotoxin. When applied locally to individual cells, picrotoxin lowered spike threshold and induced spontaneous firing in some but not all cells tested. The results suggest that picrotoxin-induced convulsive activity involves rapidly summating synaptic activity which may be evoked by high-frequency repetitive firing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barker, J L -- MacDonald, J F -- New York, N.Y. -- Science. 1980 May 30;208(4447):1054-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7375918" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Animals ; Calcium/pharmacology ; Cells, Cultured ; Magnesium/pharmacology ; Membrane Potentials/drug effects ; Mice ; Picrotoxin/*pharmacology ; Seizures/*chemically induced ; Spinal Cord/*drug effects/physiology ; Synapses/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 76
    facet.materialart.
    Unknown
    Age-related changes in passive avoidance retention: modulation with dietary choline (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bartus, R T -- Dean, R L -- Goas, J A -- Lippa, A S -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):301-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7384805" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Oral ; Aging ; Animals ; Avoidance Learning/*drug effects ; Choline/administration & dosage/*pharmacology ; Mice ; Mice, Inbred Strains ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 77
    facet.materialart.
    Unknown
    Antibody to spermine: a natural biological constituent (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-06-06
    Description: A protein that binds spermine specifically was separated from normal rabbit serum by affinity chromatography. Immunoelectrophoresis, the Ouchterlony immunodiffusion test, and gradient gel electrophoresis indicated that this protein has immunoglobulin characteristics and consists of several populations of antibodies to spermine. These were sequentially released from Sepharose-spermine gel by step-wise elution with solutions ranging in pH from 4 to 1. The binding constants varied from 5.0 x 10(8) to 11.1 x 10(8) liters per mole. These globulins did not react with monoacetylputrescine, L-ornithine, L-lysine, and histamine. Negligible cross-reactivity was detected with spermidine, putrescine, N8-monoacetylspermidine, cadaverine, and diaminopropane. Since perturbations in polyamine metabolism have been identified in several diseases, the study of extracellular polyamine homeostasis may reveal an important regulatory function for this protein.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bartos, D -- Bartos, F -- Campbell, R A -- Grettie, D P -- Smejtek, P -- New York, N.Y. -- Science. 1980 Jun 6;208(4448):1178-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7375929" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies/*isolation & purification ; Binding Sites, Antibody ; Chromatography, Affinity ; Homeostasis ; Immunoglobulin G/isolation & purification ; Kinetics ; Rabbits ; Spermine/*immunology/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 78
    facet.materialart.
    Unknown
    Sex differences in mathematical ability: fact or artifact? (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-12-12
    Description: A substantial sex difference in mathematical reasoning ability (score on the mathematics test of the Scholastic Aptitude Test) in favor of boys was found in a study of 9927 intellectually gifted junior high school students. Our data contradict the hypothesis that differential course-taking accounts for observed sex differences in mathematical ability, but support the hypothesis that these differences are somewhat increased by environmental influences.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Benbow, C P -- Stanley, J C -- New York, N.Y. -- Science. 1980 Dec 12;210(4475):1262-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7434028" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Environment ; Female ; Humans ; Intelligence ; Logic ; Male ; Mathematics ; *Sex ; Sociology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 79
    facet.materialart.
    Unknown
    Site-specific X-chromosome rearrangements from hybrid dysgenesis in Drosophila melanogaster (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-01
    Description: When the germ line of Drosophila males is destabilized by a syndrome known as hybrid dysgenesis, X-chromosome rearrangements are found in up to 10 percent of the gametes produced. Some of these aberrations are simple inversions, but many are complex multibreak rearrangements. Furthermore, most of the breakpoints fall into a few highly localized positions on the chromosome. These positions are mostly at points of intercalary heterochromatin and may vary from one strain to the next. the results suggest that they may represent points of insertion of mobile DNA sequences.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berg, R -- Engels, W R -- Kreber, R A -- GM 07131/GM/NIGMS NIH HHS/ -- GM 22038/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1980 Oct;210(4468):427-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6776625" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Inversion ; Chromosome Mapping ; DNA/genetics ; Drosophila melanogaster/*genetics ; Female ; Male ; Meiosis ; Repetitive Sequences, Nucleic Acid ; *Sex Chromosomes ; Translocation, Genetic ; *X Chromosome
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 80
    facet.materialart.
    Unknown
    Mouse leukemia: therapy with monoclonal antibodies against a thymus differentiation antigen (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-04
    Description: Monoclonal antibodies against a thymus cell differentiation antigen (Thy-1.1) were effective in the therapy of a transplanted mouse leukemia. Passive immunization resulted in high titers of cytotoxic antibody in the serum of treated mice and the suppression of metastatic tumor cells. The tumor-suppressive effects of the monoclonal antibodies were amplified by the administration of exogenous complement. This combined antibody and complement therapy resulted in the cure of leukemia in a significant proportion of the treated animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bernstein, I D -- Tam, M R -- Nowinski, R C -- New York, N.Y. -- Science. 1980 Jan 4;207(4426):68-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6965328" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibody Specificity ; Antigens, Surface ; Antilymphocyte Serum/*therapeutic use ; Cell Differentiation ; Clone Cells/immunology ; Cytotoxicity, Immunologic ; Immunotherapy ; Leukemia, Experimental/surgery/*therapy ; Mice ; Mice, Inbred Strains ; Neoplasm Metastasis ; T-Lymphocytes/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 81
    facet.materialart.
    Unknown
    Adrenocorticotropic hormone may be transported directly from the pituitary to the brain (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-31
    Description: Experiments were designed to test the hypothesis that pituitary hormones may be delivered directly to the brain. Concentrations of adrenocorticotropic hormone (ACTH) in the plasma were determined in blood samles obtained simultaneously from the carotid artery, the sagittal sinus, and the jugular vein of three awake sheep. Seizures were induced electrically to stimulate ACTH secretion, and at precise intervals thereafter several simultaneous comparisons were made in each animal. In many of the post-seizure comparisons, the ACTH plasma concentrations within the sagital sinus exceeded those within the carotid artery as well as those within the jugular vein, indicating that this hormone was released from the pituitary and carried directly through capillary beds of brain to the venous blood within the sagittal sinus. The experiment was repeated in one hypophysectomized sheep and, in this animal, ACTH concentration in the plasma was reduced, but that in the sagittal sinus still was elevated after the seizure, an indication that some ACTH (or ACTH-like material) was released from the brain itself.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bergland, R -- Blume, H -- Hamilton, A -- Monica, P -- Paterson, R -- New York, N.Y. -- Science. 1980 Oct 31;210(4469):541-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6252607" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/*blood ; Animals ; Blood-Brain Barrier ; Brain/*blood supply ; Carotid Arteries ; Epilepsy, Tonic-Clonic/blood ; Female ; Hypophysectomy ; Jugular Veins ; Male ; Sheep ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 82
    facet.materialart.
    Unknown
    Abnormality of the X chromosome in human 46,XY female siblings with dysgenetic ovaries (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-15
    Description: An abnormal extra band was found on the short arm of the X chromosome in a 46,XY female and in her 46,XY female fetal sibling. Despite presence of the intact Y chromosome, there was no evidence of testicular differentiation in either subject. Production of H-Y antigen was suppressed in both subjects. The data suggest that development of the mammalian testis requires a normal function of the X chromosome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bernstein, R -- Koo, G C -- Wachtel, S S -- New York, N.Y. -- Science. 1980 Feb 15;207(4432):768-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7352285" target="_blank"〉PubMed〈/a〉
    Keywords: Female ; Gonadal Dysgenesis/*genetics ; Gonadal Dysgenesis, 46,XY/*genetics ; H-Y Antigen/analysis/genetics ; Humans ; Male ; Ovary/abnormalities/embryology ; Sex Chromosome Aberrations/*genetics ; *Sex Chromosomes ; Sex Determination Analysis ; Testis/embryology ; *X Chromosome
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 83
    facet.materialart.
    Unknown
    Suckling (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-03
    Description: Suckling is the only behavior that is common among mammals. In newborn albino rats it is originally elicited by amniotic fluid deposited by the mother during parturition. Subsequent suckling is stimulated by saliva deposited on the nipples by the infant rats. Internal controls over the volume of milk suckled do not appear until infant rats are about 2 weeks of age at which time gastric distension, milk, systemic dehydration, and intestinal hormone cholecystokinin suppress milk intake derived through suckling. The development of controls over suckling appetite appears to parallel that of consummatory control. Until about 2 weeks of age infant rats choose to suckle a nonlactating nipple with the same frequency as a lactating nipple. Thereafter, the lactating nipple is unanimously chosen. These studies suggest differences and commonalities in the suckling behavior of laboratory rats and other mammals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blass, E M -- Teicher, M H -- AM-18560/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1980 Oct 3;210(4465):15-22.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6997992" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Population Groups/*physiology ; Animals ; Animals, Suckling/*physiology ; Cholecystokinin/physiology ; Dehydration ; Feeding Behavior/physiology ; Female ; Food Deprivation ; Humans ; Instinct ; Lactation ; Lithium/pharmacology ; Maternal Behavior ; Pheromones ; Pregnancy ; Rats ; Saliva ; Sucking Behavior/drug effects/*physiology ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 84
    facet.materialart.
    Unknown
    Limitations of metabolic activation systems used with in vitro tests for carcinogens (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-25
    Description: Important differences between the metabolic activation of 7,12-dimethylbenz[a]anthracene in intact cellular systems and in liver homogenates suggest that the use of homogenates in conjunction with short-term assays for carcinogens could yield misleading results.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bigger, C A -- Tomaszewski, J E -- Dipple, A -- Lake, R S -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):503-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6771871" target="_blank"〉PubMed〈/a〉
    Keywords: 9,10-Dimethyl-1,2-benzanthracene/*metabolism ; Animals ; Benz(a)Anthracenes/*metabolism ; Carcinogens/*metabolism ; Cells, Cultured ; DNA/metabolism ; Deoxyribonucleosides ; Drug Evaluation, Preclinical/methods ; Humans ; Liver/*metabolism ; Mice ; Microsomes, Liver/metabolism ; Rats ; Skin/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 85
    facet.materialart.
    Unknown
    Does malnutrition affect fecundity? A summary of evidence (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-05-09
    Description: Moderate chronic malnutrition has only a minor effect on fecundity (reproductive capacity), and the resulting effect on fertility (actural reproduction) is very small. Among the fecundity components examined here in noncontracepting populations, age at menarche and the duration of lactational amenorrhea appear to be the ones most affected by malnutrition. But from neither of those effects can a difference in fertility of more than a few percent be expected between poorly and well-nourished women in developing countries.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bongaarts, J -- New York, N.Y. -- Science. 1980 May 9;208(4444):564-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7367878" target="_blank"〉PubMed〈/a〉
    Keywords: Abortion, Induced ; Adolescent ; Adult ; Age Factors ; Behavior ; Birth Intervals ; Contraception ; Female ; *Fertility ; Fetal Death/epidemiology ; Humans ; Lactation ; Male ; Marriage ; Menarche ; Menopause ; Middle Aged ; Nutrition Disorders/*physiopathology ; Nutritional Physiological Phenomena ; Ovulation ; Pregnancy ; Spermatogenesis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 86
    facet.materialart.
    Unknown
    Electrophoretic injection of a fluorescent dye into giant mitochondria and mitoplasts (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-09-12
    Description: Studies of the electrical properties of giant mitochondria and mitoplasts with microelectrodes have indicated that there are no significant metabolically dependent membrane potentials. The internal location of the microelectrode has been confirmed by electrophoretically microinjecting the water-soluble dye Lucifer yellow CH into giant mitochondria or mitoplasts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bowman, C -- Tedeschi, H -- New York, N.Y. -- Science. 1980 Sep 12;209(4462):1251-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7403882" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Electrophoresis ; Fluorescent Dyes/*administration & dosage ; Membrane Potentials ; Mice ; Microelectrodes ; Mitochondria, Liver/*physiology/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 87
    facet.materialart.
    Unknown
    Hormone accumulation in a sexually dimorphic motor nucleus of the rat spinal cord (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-31
    Description: The fifth and sixth lumbar segments of the rat spinal cord were found to contain a sexually dimorphic nucleus, the spinal nucleus of the bulbocavernosus (SNB). The SNB, which contains motoneurons innervating perineal striated muscles in normal male rats, is adiminished or absent in normal females and in males with a genetic mutation rendering them insensitive to androgens. The presence of the nucleus is apparently not dependent on genetic sex, but on the action of androgens. The motoneurons of the adult male SNGH accumulate hormone after systemic injections of radioactive testosterone or dihydrotestosterone, but not estradiol, and the SNB motoneurons accumulate more of the injected androgens than do other motoneurons in the same spinal segments. These results demonstrate a morphological sex difference in hormone-sensitive motoneurons that are probably involved in the sexually dimorphic copulatory behavior of the rat.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Breedlove, S M -- Arnold, A P -- 5-S07/PHS HHS/ -- RR07009-14/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1980 Oct 31;210(4469):564-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7423210" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoradiography ; Copulation/physiology ; Dihydrotestosterone/*metabolism ; Estradiol/*metabolism ; Female ; Male ; Motor Neurons/*metabolism ; Rats ; Sex ; Spinal Cord/*metabolism ; Testosterone/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 88
    facet.materialart.
    Unknown
    Hybrid dysgenesis in Drosophila melanogaster (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-08
    Description: Several dysgenic traits may occur within the Drosophila melanogaster species as a result of crosses between different strains. Crossing two mutually interacting categories, named inducer and reactive, may lead, among other abnormalities, to a specific kind of female sterility that has proved useful for investigating the genetic factors involved in the interaction. The reactive state appears to result from a cytoplasmic state ultimately controlled by a chromosomal polygenic system. The inducer character is determined by a chromosomal factor that exhibits all characteristics of a transposable element. Overall, the data contribute to clarification of mutator activities in D. melanogaster and open new opportunities to investigate unusual genetic mechanisms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bregliano, J C -- Picard, G -- Bucheton, A -- Pelisson, A -- Lavige, J M -- L'Heritier, P -- New York, N.Y. -- Science. 1980 Feb 8;207(4431):606-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6766221" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Animals, Laboratory/genetics ; Animals, Wild/genetics ; Cytoplasm/physiology ; Drosophila melanogaster/*genetics ; Ecology ; Female ; Genes, Regulator ; Hot Temperature ; Hybridization, Genetic ; Infertility, Female/genetics ; Mutation ; Oocytes/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 89
    facet.materialart.
    Unknown
    Histamine-mediated delayed permeability response after scald burn inhibited by cimetidine or cold-water treatment (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-15
    Description: Scald injury to one ear of the hairless mouse induced significant (P 〈 .05) delayed edema formation in remote, uninjured skin. This remote edema formation was completely inhibited by immediate cold-water treatment of the scalded ear. Cold-water treatment significantly reduced histamine loss from the scalded ear, and the edema-inhibiting effect of the treatment could be mimicked by treating the animal prior to injury with the H2-histamine receptor antagonist cimetidine or a drug that causes histamine depletion. These observations suggest (i) that a histamine-mediated, delayed permeability response occurs after thermal injury that causes remote edema formation and (ii) that one mechanism of remote edema inhibition by cold-water treatment is the prevention of histamine release from thermally injured tissues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boykin, J V Jr -- Eriksson, E -- Sholley, M M -- Pittman, R N -- New York, N.Y. -- Science. 1980 Aug 15;209(4458):815-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6157189" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Burns/complications/physiopathology/*therapy ; Cell Membrane Permeability ; Cimetidine/*pharmacology ; *Cold Temperature ; Edema/etiology/physiopathology ; Guanidines/*pharmacology ; Histamine Release/*drug effects ; Indomethacin/pharmacology ; Male ; Mice ; Receptors, Histamine H2/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 90
    facet.materialart.
    Unknown
    Tritiated imipramine binding sites are decreased in platelets of untreated depressed patients (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-11
    Description: The high-affinity binding of triatiated imipramine to platelet membranes was compared in samples from 16 untreated depressed women and 21 age-matched controls of the same sex. The maximal binding in the depressed group was significantly lower than that of the controls, although the affinity constants were similar. These results suggest that binding of tritiated imipramine in human platelets may represent a biochemical index of depression, possibly reflecting similar changes in the brain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Briley, M S -- Langer, S Z -- Raisman, R -- Sechter, D -- Zarifian, E -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):303-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7384806" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Blood Platelets/*analysis ; Cell Membrane/metabolism ; Depression/*blood ; Humans ; Imipramine/*blood ; Kinetics ; Middle Aged ; Receptors, Drug/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 91
    facet.materialart.
    Unknown
    A bank for Nobel sperm (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broad, W J -- New York, N.Y. -- Science. 1980 Mar 21;207(4437):1326-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7355292" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Female ; Humans ; *Insemination, Artificial ; *Insemination, Artificial, Heterologous ; Male ; *Nobel Prize ; *Spermatozoa ; *Tissue Banks ; Tissue Donors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 92
    facet.materialart.
    Unknown
    Inhibition of cell motility by interferon (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-05-02
    Description: Interferon derived from human leukocytes, human fibroblasts, and mouse fibroblasts was found to inhibit the motility of cultured cells. It inhibits the tumor-induced motility of capillary endothelial cells as well as the spontaneous migration of other cell types. The ability of a given preparation of interferon to inhibit the motility of a given cell type is proportional to its antiviral activity in that particular cell type. Antiserum to human leukocyte interferon neutralizes both the motility-inhibitory activity and the antiviral activity of this preparation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brouty-Boye, D -- Zetter, B R -- New York, N.Y. -- Science. 1980 May 2;208(4443):516-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6154315" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antineoplastic Agents ; Antiviral Agents ; Capillaries/cytology ; Cattle ; *Cell Movement ; Cells, Cultured/physiology ; Endothelium/cytology ; Fibroblasts ; Humans ; Interferons/*pharmacology ; Leukocytes/physiology ; Mice ; Neoplasms/pathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 93
    facet.materialart.
    Unknown
    Excitatory and inhibitory effects of serotonin on sensorimotor reactivity measured with acoustic startle (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-25
    Description: Serotonin infused into the lateral ventricle in rats produced a dose-dependent depression of the acoustic startle reflex. When infused onto the spinal cord, serotonin produced a dose-dependent increase in startle. Thus the same neurotransmitter can modulate the same behavior in opposite ways, depending on which part of the central nervous system is involved.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davis, M -- Strachan, D I -- Kass, E -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):521-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7394520" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Drug ; Kinetics ; Male ; Rats ; Reflex, Acoustic/*drug effects ; Reflex, Startle/*drug effects ; Serotonin/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 94
    facet.materialart.
    Unknown
    gamma-Glutamyl transpeptidase in isolated brain endothelial cells: induction by glial cells in vitro (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-08
    Description: The endothelia of microvessels isolated from mouse brain by mechanical means are rich in gamma-glutamyl transpeptidase; however, the enzyme often disappears when the cells migrate or proliferate from the microvessel isolates. In an endothelial cell line derived from similar isolates and negative for gamma-glutamyl transpeptidase, the enzyme could be induced in the endothelial cells when they were cocultured with glial cells. Thus there may be a requirement for continuous induction of gamma-glutamyl transpeptidase in brain microvessels by adjacent glial cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉DeBault, L E -- Cancilla, P A -- New York, N.Y. -- Science. 1980 Feb 8;207(4431):653-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6101511" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*blood supply ; Capillaries/*enzymology ; Cells, Cultured ; Endothelium/enzymology ; Enzyme Induction ; Glioma/physiopathology ; Mice ; Neuroglia/*physiology ; Rats ; gamma-Glutamyltransferase/*biosynthesis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 95
    facet.materialart.
    Unknown
    A nonadrenergic vagal inhibitory pathway to feline airways (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-04-11
    Description: In cats anesthetized with chloralose-pentobarbital and artificially ventilated, electrical stimulation of the caudal end of the cut cervical vagus nerve has a biphasic effect on the bronchoconstriction induced by an intravenous infusion of serotonin. The response consists of a brief augmentation of bronchoconstriction followed by relatively prolonged bronchodilation. After muscarinic receptor blockade with atropine, vagal stimulation causes only bronchodilation. Vagally mediated bronchodilation is not affected by beta adrenergic blockade with propranolol, alpha adrenergic blockade with phenoxybenzamine, or adrenergic neuronal blockade with guanethidine, but is abolished by autonomic ganglionic blockade with hexamethonium. These findings support the conclusion that a nonadrenergic inhibitory nervous system is present in the pulmonary airways of the cat and that the system is supplied by preganglionic fibers in the cervical vagus nerves.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diamond, L -- O'Donnell, M -- New York, N.Y. -- Science. 1980 Apr 11;208(4440):185-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7361114" target="_blank"〉PubMed〈/a〉
    Keywords: Airway Resistance/drug effects ; Animals ; Cats/anatomy & histology/*physiology ; Electric Stimulation ; Female ; Guanethidine/pharmacology ; Hexamethonium Compounds/pharmacology ; Lung/*innervation ; Lung Compliance/drug effects ; Neural Pathways/physiology ; Parasympathetic Nervous System/physiology ; Phenoxybenzamine/pharmacology ; Propranolol/pharmacology ; Serotonin/pharmacology ; Sympathetic Nervous System/physiology ; Vagotomy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 96
    facet.materialart.
    Unknown
    Epidermal growth factor is a major growth-promoting agent in human milk (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-10
    Description: Human milk stimulates DNA synthesis in cell cultures in which growth has been arrested. The mitogenic activity of milk is neutralized by the addition of antibody to human epidermal growth factor. The results identify epidermal growth factor as a major growth-promoting agent in breast milk.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carpenter, G -- CA24071/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1980 Oct 10;210(4466):198-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6968093" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division/drug effects ; Cells, Cultured ; DNA/biosynthesis ; Epidermal Growth Factor/analysis/*pharmacology ; Female ; Humans ; Mice ; Milk, Human/analysis/*physiology ; Mitogens ; Peptides/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 97
    facet.materialart.
    Unknown
    Sparing of the brain in neonatal undernutrition: amino acid transport and incorporation into brain and muscle (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-22
    Description: Rates of tyrosine and lysine transport and incorporation into protein were measured in control and undernourished weanling rats. Undernutrition was induced by feeding lactating dams a low protein diet (12 percent casein) from birth to day 21. At weaning, body and brain weights of undernourished rats were 50 percent and 88 percent, respectively, of control values. Lysine and tyrosine transport rates into skeletal muscle were reduced by over 75 percent, more than twice the reduction seen in brain. Rates of amino acid incorporation into muscle protein were reduced by approximately 50 percent; the change in rate of incorporation into brain protein was not statistically significant. These data indicate that, in spite of marked retardation of amino acid transport into brain, the brain seems fully capable of maintaining normal rates of protein synthesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Freedman, L S -- Samuels, S -- Fish, I -- Schwartz, S A -- Lange, B -- Katz, M -- Morgano, L -- New York, N.Y. -- Science. 1980 Feb 22;207(4433):902-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6766565" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acids/*metabolism ; Animals ; Animals, Newborn/metabolism ; Biological Transport ; Body Weight ; Brain/growth & development/*metabolism ; Disease Models, Animal ; Female ; Lactation ; Male ; Muscles/*metabolism ; Pregnancy ; Protein-Energy Malnutrition/*metabolism ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 98
    facet.materialart.
    Unknown
    Diphenylhydantoin: pre- and postnatal administration alters diazepam binding in developing rat cerebral cortex (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-04-04
    Description: Close correlations between the development of the anticonvulsant effects of diphenylhydantoin and increases in tritiated diazepam binding were observed in rats from fetal day 16 to maturation. In contrast, significant decreases in tritiated diazepam binding were observed in 2- and 3-week-old rats that were exposed in utero to diphenylhydantoin. These changes can be correlated with reported increases in seizure susceptibility after prenatal exposure to diphenylhydantoin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallager, D W -- Mallorga, P -- New York, N.Y. -- Science. 1980 Apr 4;208(4439):64-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7361107" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzodiazepines/metabolism ; Cerebral Cortex/*metabolism ; Diazepam/*metabolism ; Female ; Fetus/metabolism ; *Maternal-Fetal Exchange ; Phenytoin/administration & dosage/*pharmacology ; Pregnancy ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 99
    facet.materialart.
    Unknown
    Endorphin-mediated increases in pain threshold during pregnancy (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-10
    Description: Maternal pain thresholds in rats were determined during various stages of pregnancy and parturition by measuring the intensity of electric shock that elicited reflexive jumping. There was a gradual rise in the pain threshold between 16 and 4 days prior to parturition and a more abrupt rise 1 to 2 days before that event. This increase was abolished by long-term administration of the narcotic antagonist naltrexone. The endorphin system is thus an important component of intrinsic mechanisms that modulate responsiveness to aversive stimuli. The data also demonstrate the activation during pregnancy of an endorphin system that is apparently quiescent in nonpregnant female rats treated the same way.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gintzler, A R -- NIMH GRANT DA01771/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1980 Oct 10;210(4466):193-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7414330" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Drug ; Endorphins/antagonists & inhibitors/*physiology ; Female ; Naltrexone/pharmacology ; Pain/*physiopathology ; Pregnancy ; *Pregnancy, Animal ; Rats ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 100
    facet.materialart.
    Unknown
    Privacy, confidentiality, and the use of medical records in research (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gordis, L -- Gold, E -- New York, N.Y. -- Science. 1980 Jan 11;207(4427):153-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7350648" target="_blank"〉PubMed〈/a〉
    Keywords: Cardiovascular Diseases/etiology ; *Confidentiality ; Diethylstilbestrol/adverse effects ; Disease Outbreaks/etiology ; *Epidemiologic Methods ; Female ; Humans ; Informed Consent ; Male ; *Medical Records ; Neoplasms/etiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...