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  • 1
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    Allele increasing susceptibility to human breast cancer may be linked to the glutamate-pyruvate transaminase locus (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-04-25
    Description: The patterns of the occurrence of breast cancer in 11 high-risk families were evaluated by segregation and linkage analysis. These patterns were consistent with the hypothesis that increased susceptibility to breast cancer was inherited as an autosomal dominant allele with high penetrance in women. The postulated susceptibility allele in these families may be chromosomally linked to the glutamate-pyruvate transaminase (E.C. 2.6.1.2, alanine aminotransferase) locus. Confirmation of this linkage in other families would establish the existence of a gene increasing susceptibility to breast cancer. Since there is no association in the general population between a woman's glutamate-pyruvate transaminase genotype and her cancer risk, the glutamate-pyruvate transaminase linkage cannot be used as a screening test for breast cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉King, M C -- Go, R C -- Elston, R C -- Lynch, H T -- Petrakis, N L -- New York, N.Y. -- Science. 1980 Apr 25;208(4442):406-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7367867" target="_blank"〉PubMed〈/a〉
    Keywords: Alanine Transaminase/*genetics ; Alleles ; Breast Neoplasms/*genetics/transmission ; Female ; Genes ; Genetic Linkage ; Humans ; Pedigree ; X Chromosome
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
    Electronic Resource
    Electronic Resource
    AUGMENTATION OF THE ANTIBODY RESPONSE BY HAPTEN HELP (1985)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 12 (1985), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The purpose of the present work was to characterize the immune response (Ir) genes that influence augmentation of the antibody response by help with the hapten azobenzene-arsonate (ABA). Hapten help was measured as the augmentation in the plaque-forming cell (PFC) response to bovine gamma gloulin (BGG) after priming mice with ABA conjugated to ovalbumin (OVA) and challenging subsequently with ABA-BGG. The first approach involved inbred mouse strains that were matched for H-2 but differed in their non-H-2 genetic backgrounds. B10.D2 mice were low responders even though they shared the H-2d haplotype with BALB/c and DBA/2 mice, which were high responders. C57BL/10 mice were high responders even though they shared the H-2b haplotype with C57BL/6, C3H.SW, and A.BY mice, all of which were strains that were low responders. The second approach was to identify any segregation of H-2 woth the gene(s) encoding susceptibility to hapten help in the backcross generation. (BALB/c x C57BL/6) F1 hybrids were backcrossed to C57BL/6. The results showed no association with the major histocompatibility complex (MHC).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1985.tb00850.x
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  • 3
    Electronic Resource
    Electronic Resource
    Statistical Modeling and Analysis in Human Genetics (1978)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biophysics and Biomolecular Structure 7 (1978), S. 253-286 
    Details
    ISSN: 0084-6589
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.bb.07.060178.001345
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  • 4
    Electronic Resource
    Electronic Resource
    Coagulation factor XIII: A useful polymorphic genetic marker (1984)
    Springer
    Human genetics 〈Berlin〉 67 (1984), S. 132-135 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The plasmas of two groups of subjects were examined for blood coagulation Factor XIII-A (FXIII-A, F13A) by electrophoresis in agarose using a Tris-EDTA-borate buffer to separate the common variants, F13A*1, F13A*2, and F13A*3. Dimeric subunits were visualized in UV light as monodansyl cadaverine bound to casein at the position of the transglutaminase activity representing F13A. One test group consisted of 307 members of three large Caucasian families. The other consisted of 148 consecutive patients whose plasmas had been sent to the clinical laboratory for determination of prothrombin time. Segregation analysis and father-to-son transmission confirmed that F13A is inherited as an autosomal co-dominant trait. The allelic frequencies in the random sample were F13A*1=0.82 and F13A*2=0.18. This sample included both blacks and whites, and the gene frequencies were not significantly different in the two races. The gene frequencies among the unrelated spouses of the three white families were A*1=0.75, A*2=0.24, A*3=0.01. Genetic equilibrium was present in both groups. The degree of polymorphism, the availability of blood, the ease of assessment, the absence of selective pressure, and the uniformity of gene frequencies in two major American ethnic groups make F13A a very useful marker for linkage studies and paternity testing. F13A has been provisionally assigned to chromosome 6. Linkage analysis of our family data did not provide evidence of linkage to two chromosome 6 markers, properdin factor B (BF) and glyoxalase 1 (GLO). The highest lod score (Z) was between F13A and the Kidd (Jk) blood group (Z=0.68 at Θ-0.24).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00272987
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  • 5
    Electronic Resource
    Electronic Resource
    Linkage relationship between variable and constant region allotypic determinants of human immunoglobulin heavy chains (1980)
    [s.l.] : Nature Publishing Group
    Nature 286 (1980), S. 406-407 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Serum samples from one large black kindred (n = 80) and one large white kindred (n = 220) and from three smaller white families (" = 84) were typed for Hv(l), Km(l) and nine Gm markers (1, 2, 3, 5, 6, 13, 14, 17, 21) by our standard haemagglutination inhibition method4'8. All sera were diluted 1:16 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/286406a0
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  • 6
    Electronic Resource
    Electronic Resource
    Linkage relationships of Lp and Ag serum lipoproteins with 25 polymorphic markers (1977)
    Springer
    Human genetics 〈Berlin〉 37 (1977), S. 291-297 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Linkage relations of Lp and Ag serum lipoproteins with 25 polymorphic marker systems are examined in a large kindred of over 100 persons. The results indicate that Lp and ESD are probably closely linked and so the Lp locus may also be assigned to chromosome 13. No significant linkage is detected between Ag and the other marker systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00393611
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  • 7
    Electronic Resource
    Electronic Resource
    An approximation to the likelihood for a pedigree with loops (1996)
    Springer
    Theoretical and applied genetics 93 (1996), S. 1299-1309 
    Details
    ISSN: 1432-2242
    Keywords: Key words Likelihood  ;  Peeling  ;  Pedigree with loops  ;  Segregation analysis  ;  Linkage analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract This paper presents a new approximation to the likelihood for a pedigree with loops, based on cutting all loops and extending the pedigree at the cuts. An opimum loop-cutting strategy and an iterative extension technique are presented. The likelihood for a pedigree with loops is then approximated by the conditional likelihood for the entire cut-extended pedigree given the extended part. The approximate likelihoods are compared with the exact likelihoods obtained using the program MENDEL for several small pedigrees with loops. The approximation is efficient for large pedigrees with complex loops in terms of computing speed and memory requirements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220050369
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  • 8
    Electronic Resource
    Electronic Resource
    The finite polygenic mixed model: An alternative formulation for the mixed model of inheritance (1994)
    Springer
    Theoretical and applied genetics 88 (1994), S. 573-580 
    Details
    ISSN: 1432-2242
    Keywords: Mixed model inheritance ; Likelihood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract This paper presents a mixed model of inheritance with a finite number of polygenic loci. This model leads to a likelihood that can be calculated using efficient algorithms developed for oligogenic models. For comparison, likelihood profiles were obtained for the finite polygenic mixed model, the usual mixed model, with exact and approximate calculations, and for a class D regressive model. The profiles for the finite polygenic mixed model were closest to the profiles for the usual mixed model with exact calculations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01240920
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  • 9
    Electronic Resource
    Electronic Resource
    An approximation to the likelihood for a pedigree with loops (1996)
    Springer
    Theoretical and applied genetics 93 (1996), S. 1299-1309 
    Details
    ISSN: 1432-2242
    Keywords: Likelihood ; Peeling ; Pedigree with loops ; Segregation analysis ; Linkage analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract This paper presents a new approximation to the likelihood for a pedigree with loops, based on cutting all loops and extending the pedigree at the cuts. An opimum loop-cutting strategy and an iterative extension technique are presented. The likelihood for a pedigree with loops is then approximated by the conditional likelihood for the entire cut-extended pedigree given the extended part. The approximate likelihoods are compared with the exact likelihoods obtained using the program MENDEL for several small pedigrees with loops. The approximation is efficient for large pedigrees with complex loops in terms of computing speed and memory requirements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00223463
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  • 10
    Electronic Resource
    Electronic Resource
    An algorithm to approximate the likelihood for pedigree data with loops by cutting (1995)
    Springer
    Theoretical and applied genetics 91 (1995), S. 1054-1063 
    Details
    ISSN: 1432-2242
    Keywords: Arbitrary pedigrees with loops ; Recursive algorithm ; Peeling ; Likelihood ; Cutting loops
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract This paper presents a recursive algorithm to approximate the likelihood in arbitrary pedigrees with loops. The algorithm handles any number and nesting levels of loops in pedigrees. The loops are cut as described in a previous publication and the approximate likelihood is simultaneously computed using the cut pedigree. No identification of a loop in the pedigree is necessary before the algorithm is applied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00223919
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