ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Animals  (1,476)
  • Inorganic Chemistry  (668)
  • Analytical Chemistry and Spectroscopy
  • 2015-2019
  • 2010-2014  (1,476)
  • 1990-1994
  • 1915-1919  (668)
  • 2012  (1,476)
  • 1919  (365)
  • 1917  (303)
  • 101
    facet.materialart.
    Unknown
    Cell signaling. Putting the squeeze on phototransduction (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-10-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liman, Emily R -- New York, N.Y. -- Science. 2012 Oct 12;338(6104):200-1. doi: 10.1126/science.1229909.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA. liman@usc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23066065" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Drosophila melanogaster/*physiology ; *Evoked Potentials, Visual ; *Light Signal Transduction ; *Mechanical Processes ; *Mechanotransduction, Cellular ; Photoreceptor Cells, Invertebrate/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 102
    facet.materialart.
    Unknown
    Structure of an intermediate state in protein folding and aggregation (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-04-21
    Description: Protein-folding intermediates have been implicated in amyloid fibril formation involved in neurodegenerative disorders. However, the structural mechanisms by which intermediates initiate fibrillar aggregation have remained largely elusive. To gain insight, we used relaxation dispersion nuclear magnetic resonance spectroscopy to determine the structure of a low-populated, on-pathway folding intermediate of the A39V/N53P/V55L (A, Ala; V, Val; N, Asn; P, Pro; L, Leu) Fyn SH3 domain. The carboxyl terminus remains disordered in this intermediate, thereby exposing the aggregation-prone amino-terminal beta strand. Accordingly, mutants lacking the carboxyl terminus and thus mimicking the intermediate fail to safeguard the folding route and spontaneously form fibrillar aggregates. The structure provides a detailed characterization of the non-native interactions stabilizing an aggregation-prone intermediate under native conditions and insight into how such an intermediate can derail folding and initiate fibrillation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Neudecker, Philipp -- Robustelli, Paul -- Cavalli, Andrea -- Walsh, Patrick -- Lundstrom, Patrik -- Zarrine-Afsar, Arash -- Sharpe, Simon -- Vendruscolo, Michele -- Kay, Lewis E -- 089703/Wellcome Trust/United Kingdom -- Canadian Institutes of Health Research/Canada -- New York, N.Y. -- Science. 2012 Apr 20;336(6079):362-6. doi: 10.1126/science.1214203.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22517863" target="_blank"〉PubMed〈/a〉
    Keywords: Amyloid/*chemistry ; Animals ; Chickens ; Hydrogen Bonding ; Models, Molecular ; Molecular Dynamics Simulation ; Mutant Proteins/chemistry ; Nuclear Magnetic Resonance, Biomolecular ; Protein Conformation ; *Protein Folding ; Protein Structure, Secondary ; Proto-Oncogene Proteins c-fyn/*chemistry/genetics ; Thermodynamics ; *src Homology Domains
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 103
    facet.materialart.
    Unknown
    GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-04-28
    Description: In metazoans, cells depend on extracellular growth factors for energy homeostasis. We found that glycogen synthase kinase-3 (GSK3), when deinhibited by default in cells deprived of growth factors, activates acetyltransferase TIP60 through phosphorylating TIP60-Ser(86), which directly acetylates and stimulates the protein kinase ULK1, which is required for autophagy. Cells engineered to express TIP60(S86A) that cannot be phosphorylated by GSK3 could not undergo serum deprivation-induced autophagy. An acetylation-defective mutant of ULK1 failed to rescue autophagy in ULK1(-/-) mouse embryonic fibroblasts. Cells used signaling from GSK3 to TIP60 and ULK1 to regulate autophagy when deprived of serum but not glucose. These findings uncover an activating pathway that integrates protein phosphorylation and acetylation to connect growth factor deprivation to autophagy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, Shu-Yong -- Li, Terytty Yang -- Liu, Qing -- Zhang, Cixiong -- Li, Xiaotong -- Chen, Yan -- Zhang, Shi-Meng -- Lian, Guili -- Liu, Qi -- Ruan, Ka -- Wang, Zhen -- Zhang, Chen-Song -- Chien, Kun-Yi -- Wu, Jiawei -- Li, Qinxi -- Han, Jiahuai -- Lin, Sheng-Cai -- New York, N.Y. -- Science. 2012 Apr 27;336(6080):477-81. doi: 10.1126/science.1217032.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22539723" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Autophagy ; Cell Line ; Cell Line, Tumor ; Culture Media ; Culture Media, Serum-Free ; Glucose/metabolism ; Glycogen Synthase Kinase 3/genetics/*metabolism ; HEK293 Cells ; Histone Acetyltransferases/genetics/*metabolism ; Humans ; Intercellular Signaling Peptides and Proteins/metabolism ; Intracellular Signaling Peptides and Proteins/genetics/*metabolism ; Mice ; Phosphorylation ; Protein-Serine-Threonine Kinases/genetics/*metabolism ; Rats ; *Signal Transduction ; Trans-Activators/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 104
    facet.materialart.
    Unknown
    ENSO drove 2500-year collapse of eastern Pacific coral reefs (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-07-07
    Description: Cores of coral reef frameworks along an upwelling gradient in Panama show that reef ecosystems in the tropical eastern Pacific collapsed for 2500 years, representing as much as 40% of their history, beginning about 4000 years ago. The principal cause of this millennial-scale hiatus in reef growth was increased variability of the El Nino-Southern Oscillation (ENSO) and its coupling with the Intertropical Convergence Zone. The hiatus was a Pacific-wide phenomenon with an underlying climatology similar to probable scenarios for the next century. Global climate change is probably driving eastern Pacific reefs toward another regional collapse.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Toth, Lauren T -- Aronson, Richard B -- Vollmer, Steven V -- Hobbs, Jennifer W -- Urrego, Dunia H -- Cheng, Hai -- Enochs, Ian C -- Combosch, David J -- van Woesik, Robert -- Macintyre, Ian G -- New York, N.Y. -- Science. 2012 Jul 6;337(6090):81-4. doi: 10.1126/science.1221168.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Florida Institute of Technology, Melbourne, FL 32901, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22767927" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Anthozoa/growth & development ; Climate Change ; *Coral Reefs ; *El Nino-Southern Oscillation ; Geologic Sediments ; Pacific Ocean ; Panama ; Time
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 105
    facet.materialart.
    Unknown
    Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-01-17
    Description: The cytokine tumor necrosis factor (TNF) is the primary trigger of inflammation. Like many extracellular signaling proteins, TNF is synthesized as a transmembrane protein; the active signal is its ectodomain, which is shed from cells after cleavage by an ADAM family metalloprotease, ADAM17 (TNFalpha-converting enzyme, TACE). We report that iRhom2 (RHBDF2), a proteolytically inactive member of the rhomboid family, is required for TNF release in mice. iRhom2 binds TACE and promotes its exit from the endoplasmic reticulum. The failure of TACE to exit the endoplasmic reticulum in the absence of iRhom2 prevents the furin-mediated maturation and trafficking of TACE to the cell surface, the site of TNF cleavage. Given the role of TNF in autoimmune and inflammatory diseases, iRhom2 may represent an attractive therapeutic target.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272371/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272371/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Adrain, Colin -- Zettl, Markus -- Christova, Yonka -- Taylor, Neil -- Freeman, Matthew -- MC_U105178780/Medical Research Council/United Kingdom -- U.1051.01.009(78780)/Medical Research Council/United Kingdom -- U105178780/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2012 Jan 13;335(6065):225-8. doi: 10.1126/science.1214400.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22246777" target="_blank"〉PubMed〈/a〉
    Keywords: ADAM Proteins/*metabolism ; Animals ; Carrier Proteins/genetics/*metabolism ; Cell Line ; Cell Membrane/metabolism ; Endoplasmic Reticulum/metabolism ; Enzyme Activation ; Furin/metabolism ; Humans ; Lipopolysaccharides/immunology ; Macrophages/metabolism ; Mice ; Mice, Knockout ; Protein Binding ; Protein Transport ; *Signal Transduction ; Tumor Necrosis Factor-alpha/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 106
    facet.materialart.
    Unknown
    Public health. Monitoring EU emerging infectious disease risk due to climate change (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-04-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lindgren, Elisabet -- Andersson, Yvonne -- Suk, Jonathan E -- Sudre, Bertrand -- Semenza, Jan C -- New York, N.Y. -- Science. 2012 Apr 27;336(6080):418-9. doi: 10.1126/science.1215735.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22539705" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Climate Change ; Communicable Diseases, Emerging/*epidemiology/veterinary ; Disease Vectors ; Europe/epidemiology ; *European Union ; Humans ; Internationality ; Mandatory Reporting ; *Population Surveillance ; Risk Assessment
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 107
    facet.materialart.
    Unknown
    Hippocampal place fields emerge upon single-cell manipulation of excitability during behavior (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-08-21
    Description: The origin of the spatial receptive fields of hippocampal place cells has not been established. A hippocampal CA1 pyramidal cell receives thousands of synaptic inputs, mostly from other spatially tuned neurons; however, how the postsynaptic neuron's cellular properties determine the response to these inputs during behavior is unknown. We discovered that, contrary to expectations from basic models of place cells and neuronal integration, a small, spatially uniform depolarization of the spatially untuned somatic membrane potential of a silent cell leads to the sudden and reversible emergence of a spatially tuned subthreshold response and place-field spiking. Such gating of inputs by postsynaptic neuronal excitability reveals a cellular mechanism for receptive field origin and may be critical for the formation of hippocampal memory representations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, Doyun -- Lin, Bei-Jung -- Lee, Albert K -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2012 Aug 17;337(6096):849-53. doi: 10.1126/science.1221489.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, VA 20147, USA. leed@janelia.hhmi.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22904011" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; CA1 Region, Hippocampal/cytology/*physiology ; *Excitatory Postsynaptic Potentials ; *Memory ; Pyramidal Cells/*physiology ; Rats ; *Spatial Behavior ; Synapses/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 108
    facet.materialart.
    Unknown
    The structure of native influenza virion ribonucleoproteins (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-11-28
    Description: The influenza viruses cause annual epidemics of respiratory disease and occasional pandemics, which constitute a major public-health issue. The segmented negative-stranded RNAs are associated with the polymerase complex and nucleoprotein (NP), forming ribonucleoproteins (RNPs), which are responsible for virus transcription and replication. We describe the structure of native RNPs derived from virions. They show a double-helical conformation in which two NP strands of opposite polarity are associated with each other along the helix. Both strands are connected by a short loop at one end of the particle and interact with the polymerase complex at the other end. This structure will be relevant for unraveling the mechanisms of nuclear import of parental virus RNPs, their transcription and replication, and the encapsidation of progeny RNPs into virions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arranz, Rocio -- Coloma, Rocio -- Chichon, Francisco Javier -- Conesa, Jose Javier -- Carrascosa, Jose L -- Valpuesta, Jose M -- Ortin, Juan -- Martin-Benito, Jaime -- New York, N.Y. -- Science. 2012 Dec 21;338(6114):1634-7. doi: 10.1126/science.1228172. Epub 2012 Nov 22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Macromolecular Structure, Centro Nacional de Biotecnologia [Consejo Superior de Investigaciones Cienficas (CSIC)], Madrid, Spain.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23180776" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Nucleus/metabolism/virology ; Cryoelectron Microscopy ; Electron Microscope Tomography ; Image Processing, Computer-Assisted ; Influenza A Virus, H1N1 Subtype/*chemistry/physiology/ultrastructure ; Madin Darby Canine Kidney Cells ; Microscopy, Electron ; Models, Molecular ; Protein Conformation ; Protein Structure, Secondary ; RNA Replicase/chemistry/metabolism/ultrastructure ; RNA, Viral/*chemistry/metabolism ; RNA-Binding Proteins/chemistry/metabolism/ultrastructure ; Ribonucleoproteins/*chemistry/metabolism/ultrastructure ; Transcription, Genetic ; Viral Core Proteins/chemistry/metabolism/ultrastructure ; Viral Proteins/*chemistry/metabolism/ultrastructure ; Virion/*chemistry/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 109
    facet.materialart.
    Unknown
    Molecular biology. All packed up and ready to go (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jacob, Yannick -- Martienssen, Rob -- R01 GM067014/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2012 Jun 15;336(6087):1391-2. doi: 10.1126/science.1224272.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22700909" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphatases/*metabolism ; Animals ; Arabidopsis/*genetics/*metabolism ; Arabidopsis Proteins/*metabolism ; *DNA Methylation ; DNA, Plant/*metabolism ; *Gene Silencing ; Heterochromatin/*metabolism ; Histone Acetyltransferases/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 110
    facet.materialart.
    Unknown
    Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-02
    Description: The circadian clock in mammals is driven by an autoregulatory transcriptional feedback mechanism that takes approximately 24 hours to complete. A key component of this mechanism is a heterodimeric transcriptional activator consisting of two basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) domain protein subunits, CLOCK and BMAL1. Here, we report the crystal structure of a complex containing the mouse CLOCK:BMAL1 bHLH-PAS domains at 2.3 A resolution. The structure reveals an unusual asymmetric heterodimer with the three domains in each of the two subunits--bHLH, PAS-A, and PAS-B--tightly intertwined and involved in dimerization interactions, resulting in three distinct protein interfaces. Mutations that perturb the observed heterodimer interfaces affect the stability and activity of the CLOCK:BMAL1 complex as well as the periodicity of the circadian oscillator. The structure of the CLOCK:BMAL1 complex is a starting point for understanding at an atomic level the mechanism driving the mammalian circadian clock.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694778/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694778/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huang, Nian -- Chelliah, Yogarany -- Shan, Yongli -- Taylor, Clinton A -- Yoo, Seung-Hee -- Partch, Carrie -- Green, Carla B -- Zhang, Hong -- Takahashi, Joseph S -- R01 GM081875/GM/NIGMS NIH HHS/ -- R01 GM090247/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2012 Jul 13;337(6091):189-94. doi: 10.1126/science.1222804. Epub 2012 May 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22653727" target="_blank"〉PubMed〈/a〉
    Keywords: ARNTL Transcription Factors/*chemistry/genetics/metabolism ; Amino Acid Sequence ; Animals ; CLOCK Proteins/*chemistry/genetics/metabolism ; Cells, Cultured ; *Circadian Rhythm ; Crystallography, X-Ray ; DNA/metabolism ; HEK293 Cells ; Helix-Loop-Helix Motifs ; Humans ; Mice ; Models, Molecular ; Molecular Sequence Data ; Mutant Proteins/chemistry/metabolism ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Multimerization ; Protein Structure, Quaternary ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Protein Subunits/chemistry/metabolism ; Static Electricity ; *Transcriptional Activation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 111
    facet.materialart.
    Unknown
    Medicine. Cardiac regeneration (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-12-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosenzweig, Anthony -- New York, N.Y. -- Science. 2012 Dec 21;338(6114):1549-50. doi: 10.1126/science.1228951.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cardiovascular Division at Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. arosenzw@bidmc.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23258880" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Marrow Transplantation ; *Cell Transplantation ; Heart/*physiology ; Heart Failure/*therapy ; Humans ; Myocytes, Cardiac/cytology/*physiology ; Randomized Controlled Trials as Topic ; *Regeneration ; Stem Cell Transplantation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 112
    facet.materialart.
    Unknown
    Functional supramolecular polymers (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-02-22
    Description: Supramolecular polymers can be random and entangled coils with the mechanical properties of plastics and elastomers, but with great capacity for processability, recycling, and self-healing due to their reversible monomer-to-polymer transitions. At the other extreme, supramolecular polymers can be formed by self-assembly among designed subunits to yield shape-persistent and highly ordered filaments. The use of strong and directional interactions among molecular subunits can achieve not only rich dynamic behavior but also high degrees of internal order that are not known in ordinary polymers. They can resemble, for example, the ordered and dynamic one-dimensional supramolecular assemblies of the cell cytoskeleton and possess useful biological and electronic functions.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291483/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291483/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Aida, T -- Meijer, E W -- Stupp, S I -- 2R01DE015920-06/DE/NIDCR NIH HHS/ -- 2R01EB003806-06A2/EB/NIBIB NIH HHS/ -- R01 DE015920/DE/NIDCR NIH HHS/ -- R01 DE015920-06/DE/NIDCR NIH HHS/ -- R01 EB003806/EB/NIBIB NIH HHS/ -- R01 EB003806-06A2/EB/NIBIB NIH HHS/ -- New York, N.Y. -- Science. 2012 Feb 17;335(6070):813-7. doi: 10.1126/science.1205962.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Biotechnology, School of Engineering, University of Tokyo, Tokyo, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22344437" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomimetic Materials/chemistry ; Forecasting ; Humans ; Molecular Structure ; Nanofibers ; Nanotubes ; *Polymers/chemistry ; Semiconductors ; Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 113
    facet.materialart.
    Unknown
    Computational approaches to developmental patterning (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-04-14
    Description: Computational approaches are breaking new ground in understanding how embryos form. Here, we discuss recent studies that couple precise measurements in the embryo with appropriately matched modeling and computational methods to investigate classic embryonic patterning strategies. We include signaling gradients, activator-inhibitor systems, and coupled oscillators, as well as emerging paradigms such as tissue deformation. Parallel progress in theory and experiment will play an increasingly central role in deciphering developmental patterning.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morelli, Luis G -- Uriu, Koichiro -- Ares, Saul -- Oates, Andrew C -- New York, N.Y. -- Science. 2012 Apr 13;336(6078):187-91. doi: 10.1126/science.1215478.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22499940" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Body Patterning ; Computational Biology ; *Computer Simulation ; Drosophila/embryology ; Embryo, Nonmammalian/cytology/metabolism ; Embryonic Development ; Gene Expression Regulation, Developmental ; Gene Regulatory Networks ; *Models, Biological ; Signal Transduction ; Zebrafish/embryology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 114
    facet.materialart.
    Unknown
    Asymmetric division of Drosophila male germline stem cell shows asymmetric histone distribution (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-11-03
    Description: Stem cells can self-renew and generate differentiating daughter cells. It is not known whether these cells maintain their epigenetic information during asymmetric division. Using a dual-color method to differentially label "old" versus "new" histones in Drosophila male germline stem cells (GSCs), we show that preexisting canonical H3, but not variant H3.3, histones are selectively segregated to the GSC, whereas newly synthesized histones incorporated during DNA replication are enriched in the differentiating daughter cell. The asymmetric histone distribution occurs in GSCs but not in symmetrically dividing progenitor cells. Furthermore, if GSCs are genetically manipulated to divide symmetrically, this asymmetric mode is lost. This work suggests that stem cells retain preexisting canonical histones during asymmetric cell divisions, probably as a mechanism to maintain their unique molecular properties.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532436/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532436/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tran, Vuong -- Lim, Cindy -- Xie, Jing -- Chen, Xin -- R01 HD065816/HD/NICHD NIH HHS/ -- R01HD065816/HD/NICHD NIH HHS/ -- R21 HD065089/HD/NICHD NIH HHS/ -- R21HD065089/HD/NICHD NIH HHS/ -- T32 GM007231/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2012 Nov 2;338(6107):679-82. doi: 10.1126/science.1226028.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23118191" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Genetically Modified ; *Asymmetric Cell Division ; Cell Differentiation ; Drosophila ; Drosophila Proteins/*metabolism ; Epigenesis, Genetic ; Germ Cells/*cytology/*metabolism ; Histones/*metabolism ; Male ; Stem Cells/*cytology/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 115
    facet.materialart.
    Unknown
    Development. Making waves for segments (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-04-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roth, Siegfried -- Panfilio, Kristen A -- New York, N.Y. -- Science. 2012 Apr 20;336(6079):306-7. doi: 10.1126/science.1222242.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Devlopmental Biology, University of Cologne, Biocenter, Zulpicher Str. 47b, 50674 Cologne, Germany. siegfried.roth@uni-koeln.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22517849" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Gene Expression Regulation, Developmental ; *Genes, Insect ; Tribolium/*embryology/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 116
    facet.materialart.
    Unknown
    Development. Cell death by glutamine repeats? (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-03-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Link, Christopher D -- Saldi, Tassa K -- R01 NS063964/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2012 Feb 24;335(6071):926-7. doi: 10.1126/science.1219834.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA. linkc@colorado.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22362996" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Caenorhabditis elegans/*cytology/*metabolism ; Caenorhabditis elegans Proteins/*genetics/*metabolism ; *Cell Death ; Male
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 117
    facet.materialart.
    Unknown
    Reproductive biology. Potential egg stem cells reignite debate (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-03-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2012 Mar 2;335(6072):1029-30. doi: 10.1126/science.335.6072.1029.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22383817" target="_blank"〉PubMed〈/a〉
    Keywords: Adult Stem Cells/*cytology ; Animals ; Cell Proliferation ; Cell Separation ; Female ; Humans ; Mice ; Oocytes/*cytology ; *Oogenesis ; Oogonia/*cytology ; Ovary/cytology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 118
    facet.materialart.
    Unknown
    Nobel Prize in physiology or medicine. Reprogrammed cells earn biologists top honor (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-10-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- Normile, Dennis -- New York, N.Y. -- Science. 2012 Oct 12;338(6104):178-9. doi: 10.1126/science.338.6104.178.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23066049" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cellular Reprogramming ; Embryonic Stem Cells/*physiology ; England ; Japan ; *Nobel Prize ; *Physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 119
    facet.materialart.
    Unknown
    An overlapping protein-coding region in influenza A virus segment 3 modulates the host response (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-30
    Description: Influenza A virus (IAV) infection leads to variable and imperfectly understood pathogenicity. We report that segment 3 of the virus contains a second open reading frame ("X-ORF"), accessed via ribosomal frameshifting. The frameshift product, termed PA-X, comprises the endonuclease domain of the viral PA protein with a C-terminal domain encoded by the X-ORF and functions to repress cellular gene expression. PA-X also modulates IAV virulence in a mouse infection model, acting to decrease pathogenicity. Loss of PA-X expression leads to changes in the kinetics of the global host response, which notably includes increases in inflammatory, apoptotic, and T lymphocyte-signaling pathways. Thus, we have identified a previously unknown IAV protein that modulates the host response to infection, a finding with important implications for understanding IAV pathogenesis.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552242/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552242/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jagger, B W -- Wise, H M -- Kash, J C -- Walters, K-A -- Wills, N M -- Xiao, Y-L -- Dunfee, R L -- Schwartzman, L M -- Ozinsky, A -- Bell, G L -- Dalton, R M -- Lo, A -- Efstathiou, S -- Atkins, J F -- Firth, A E -- Taubenberger, J K -- Digard, P -- 073126/Wellcome Trust/United Kingdom -- 088789/Wellcome Trust/United Kingdom -- G0700815/Medical Research Council/United Kingdom -- G0700815(82260)/Medical Research Council/United Kingdom -- G9800943/Medical Research Council/United Kingdom -- MR/J002232/1/Medical Research Council/United Kingdom -- Biotechnology and Biological Sciences Research Council/United Kingdom -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2012 Jul 13;337(6091):199-204. doi: 10.1126/science.1222213. Epub 2012 Jun 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Virology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22745253" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Cell Line ; Codon ; Conserved Sequence ; Female ; *Frameshifting, Ribosomal ; Gene Expression Regulation ; Genome, Viral ; HEK293 Cells ; Humans ; Influenza A Virus, H1N1 Subtype/*genetics/growth & development/pathogenicity ; Influenza A virus/*genetics/metabolism ; Lung/pathology/virology ; Mice ; Mice, Inbred BALB C ; Molecular Sequence Data ; Mutation ; *Open Reading Frames ; Orthomyxoviridae Infections/genetics/immunology/pathology/*virology ; Protein Interaction Domains and Motifs ; Proteome ; RNA Replicase/chemistry/*genetics/*metabolism ; RNA, Messenger/genetics/metabolism ; RNA, Viral/genetics/metabolism ; Reassortant Viruses/genetics ; Repressor Proteins/chemistry/*genetics/*metabolism ; Viral Nonstructural Proteins/chemistry/*genetics/*metabolism ; Viral Proteins/biosynthesis/chemistry/*genetics/*metabolism ; Virus Replication
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 120
    facet.materialart.
    Unknown
    Anticipating critical transitions (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-10-23
    Description: Tipping points in complex systems may imply risks of unwanted collapse, but also opportunities for positive change. Our capacity to navigate such risks and opportunities can be boosted by combining emerging insights from two unconnected fields of research. One line of work is revealing fundamental architectural features that may cause ecological networks, financial markets, and other complex systems to have tipping points. Another field of research is uncovering generic empirical indicators of the proximity to such critical thresholds. Although sudden shifts in complex systems will inevitably continue to surprise us, work at the crossroads of these emerging fields offers new approaches for anticipating critical transitions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Scheffer, Marten -- Carpenter, Stephen R -- Lenton, Timothy M -- Bascompte, Jordi -- Brock, William -- Dakos, Vasilis -- van de Koppel, Johan -- van de Leemput, Ingrid A -- Levin, Simon A -- van Nes, Egbert H -- Pascual, Mercedes -- Vandermeer, John -- 268732/European Research Council/International -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2012 Oct 19;338(6105):344-8. doi: 10.1126/science.1225244.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Environmental Sciences, Wageningen University, Post Office Box 47, NL-6700 AA Wageningen, Netherlands. marten.scheffer@wur.nl〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23087241" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Forecasting ; Humans ; Risk Assessment/*statistics & numerical data
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 121
    facet.materialart.
    Unknown
    Host-gut microbiota metabolic interactions (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-08
    Description: The composition and activity of the gut microbiota codevelop with the host from birth and is subject to a complex interplay that depends on the host genome, nutrition, and life-style. The gut microbiota is involved in the regulation of multiple host metabolic pathways, giving rise to interactive host-microbiota metabolic, signaling, and immune-inflammatory axes that physiologically connect the gut, liver, muscle, and brain. A deeper understanding of these axes is a prerequisite for optimizing therapeutic strategies to manipulate the gut microbiota to combat disease and improve health.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nicholson, Jeremy K -- Holmes, Elaine -- Kinross, James -- Burcelin, Remy -- Gibson, Glenn -- Jia, Wei -- Pettersson, Sven -- R01AA020212/AA/NIAAA NIH HHS/ -- Biotechnology and Biological Sciences Research Council/United Kingdom -- Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2012 Jun 8;336(6086):1262-7. doi: 10.1126/science.1223813. Epub 2012 Jun 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK. j.nicholson@imperial.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22674330" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Bacteria/*metabolism ; Diet ; Gastrointestinal Tract/*metabolism/*microbiology ; Health ; Humans ; Immune System/physiology ; Inflammation ; Liver/metabolism ; Metabolic Diseases/metabolism/*microbiology ; *Metabolic Networks and Pathways ; *Metagenome ; Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 122
    facet.materialart.
    Unknown
    Benefits and risks of influenza research: lessons learned (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-23
    Description: Given the yearly challenge of seasonal influenza and the potential catastrophic consequences of future pandemics, the need for intensive basic and clinical influenza research is unquestionable. Although the fruits of decades of research have enabled dramatic improvements in our ability to prevent and treat influenza, many fundamental questions remain, including those related to the complex factors associated with host switching and transmission of influenza viruses. Recent public concern over two H5N1 influenza manuscripts that studied the transmissibility of influenza viruses has triggered intense discussion on dual-use research and the way forward.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fauci, Anthony S -- Collins, Francis S -- New York, N.Y. -- Science. 2012 Jun 22;336(6088):1522-3. doi: 10.1126/science.1224305.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Institutes of Health, Bethesda, MD 20892, USA. afauci@niaid.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22723407" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Animals ; *Biomedical Research ; Bioterrorism ; Disease Models, Animal ; Evolution, Molecular ; Ferrets ; Humans ; Influenza A Virus, H5N1 Subtype/*genetics/*pathogenicity ; Influenza, Human/mortality/transmission/*virology ; Mutation ; National Institutes of Health (U.S.) ; Orthomyxoviridae Infections/transmission/*virology ; Public Health ; Public Policy ; *Publishing ; Reassortant Viruses/genetics/pathogenicity ; Risk Assessment ; Security Measures ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 123
    facet.materialart.
    Unknown
    Camouflage and display for soft machines (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-08-21
    Description: Synthetic systems cannot easily mimic the color-changing abilities of animals such as cephalopods. Soft machines--machines fabricated from soft polymers and flexible reinforcing sheets--are rapidly increasing in functionality. This manuscript describes simple microfluidic networks that can change the color, contrast, pattern, apparent shape, luminescence, and surface temperature of soft machines for camouflage and display. The color of these microfluidic networks can be changed simultaneously in the visible and infrared--a capability that organisms do not have. These strategies begin to imitate the functions, although not the anatomies, of color-changing animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morin, Stephen A -- Shepherd, Robert F -- Kwok, Sen Wai -- Stokes, Adam A -- Nemiroski, Alex -- Whitesides, George M -- New York, N.Y. -- Science. 2012 Aug 17;337(6096):828-32. doi: 10.1126/science.1222149.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22904008" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cephalopoda/chemistry ; *Color ; Luminescence ; Microfluidics/*methods ; *Molecular Mimicry ; *Pigmentation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 124
    facet.materialart.
    Unknown
    Biochemistry. Visualizing amyloid assembly (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-04-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eliezer, David -- New York, N.Y. -- Science. 2012 Apr 20;336(6079):308-9. doi: 10.1126/science.1220356.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Program in Structural Biology, Weill Cornell Medical College, New York, NY 10065, USA. dae2005@med.cornell.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22517851" target="_blank"〉PubMed〈/a〉
    Keywords: Amyloid/*chemistry ; Animals ; *Protein Folding ; Proto-Oncogene Proteins c-fyn/*chemistry ; *src Homology Domains
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 125
    facet.materialart.
    Unknown
    Cell biology. Rapamycin paradox resolved (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-03-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hughes, Katherine J -- Kennedy, Brian K -- New York, N.Y. -- Science. 2012 Mar 30;335(6076):1578-9. doi: 10.1126/science.1221365.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Buck Institute for Research on Aging, Novato, CA 94945, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22461595" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; *Insulin Resistance ; *Longevity ; Male ; Sirolimus/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 126
    facet.materialart.
    Unknown
    Marine science. Ocean's deep, dark trenches to get their moment in the spotlight (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-04-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, Jane J -- New York, N.Y. -- Science. 2012 Apr 13;336(6078):141-3. doi: 10.1126/science.336.6078.141.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22499911" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Aquatic Organisms/physiology ; *Ecosystem ; Marine Biology/instrumentation/methods ; Pacific Ocean ; Pressure ; *Seawater
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 127
    facet.materialart.
    Unknown
    The aftermath of megafaunal extinction: ecosystem transformation in Pleistocene Australia (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-03-24
    Description: Giant vertebrates dominated many Pleistocene ecosystems. Many were herbivores, and their sudden extinction in prehistory could have had large ecological impacts. We used a high-resolution 130,000-year environmental record to help resolve the cause and reconstruct the ecological consequences of extinction of Australia's megafauna. Our results suggest that human arrival rather than climate caused megafaunal extinction, which then triggered replacement of mixed rainforest by sclerophyll vegetation through a combination of direct effects on vegetation of relaxed herbivore pressure and increased fire in the landscape. This ecosystem shift was as large as any effect of climate change over the last glacial cycle, and indicates the magnitude of changes that may have followed megafaunal extinction elsewhere in the world.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rule, Susan -- Brook, Barry W -- Haberle, Simon G -- Turney, Chris S M -- Kershaw, A Peter -- Johnson, Christopher N -- New York, N.Y. -- Science. 2012 Mar 23;335(6075):1483-6. doi: 10.1126/science.1214261.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Culture, History and Language, The Australian National University, Canberra, ACT, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22442481" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ascomycota ; Biomass ; Charcoal ; Climate Change ; *Ecosystem ; *Extinction, Biological ; Fires ; Fossils ; Herbivory ; Humans ; Plants ; Population Dynamics ; Queensland ; Time ; Trees ; *Vertebrates
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 128
    facet.materialart.
    Unknown
    Biosecurity on thin ice in Antarctica (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hulme, Philip E -- Pysek, Petr -- Winter, Marten -- New York, N.Y. -- Science. 2012 Jun 1;336(6085):1102, 1104. doi: 10.1126/science.336.6085.1102-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22654041" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antarctic Regions ; *Ecosystem ; Environment ; International Cooperation ; *Introduced Species/legislation & jurisprudence ; Plants ; Travel
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 129
    facet.materialart.
    Unknown
    Regional astrocyte allocation regulates CNS synaptogenesis and repair (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-30
    Description: Astrocytes, the most abundant cell population in the central nervous system (CNS), are essential for normal neurological function. We show that astrocytes are allocated to spatial domains in mouse spinal cord and brain in accordance with their embryonic sites of origin in the ventricular zone. These domains remain stable throughout life without evidence of secondary tangential migration, even after acute CNS injury. Domain-specific depletion of astrocytes in ventral spinal cord resulted in abnormal motor neuron synaptogenesis, which was not rescued by immigration of astrocytes from adjoining regions. Our findings demonstrate that region-restricted astrocyte allocation is a general CNS phenomenon and reveal intrinsic limitations of the astroglial response to injury.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059181/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059181/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tsai, Hui-Hsin -- Li, Huiliang -- Fuentealba, Luis C -- Molofsky, Anna V -- Taveira-Marques, Raquel -- Zhuang, Helin -- Tenney, April -- Murnen, Alice T -- Fancy, Stephen P J -- Merkle, Florian -- Kessaris, Nicoletta -- Alvarez-Buylla, Arturo -- Richardson, William D -- Rowitch, David H -- G0501173/Medical Research Council/United Kingdom -- G0800575/Medical Research Council/United Kingdom -- R01 NS028478/NS/NINDS NIH HHS/ -- R37 HD032116/HD/NICHD NIH HHS/ -- Howard Hughes Medical Institute/ -- Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2012 Jul 20;337(6092):358-62. doi: 10.1126/science.1222381. Epub 2012 Jun 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA 94143, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22745251" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Astrocytes/*physiology ; Bacterial Proteins/metabolism ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Brain/abnormalities/*cytology/physiology ; Brain Injuries/physiopathology ; *Cell Movement ; Green Fluorescent Proteins ; Homeodomain Proteins/metabolism ; Integrases/genetics ; Luminescent Proteins/metabolism ; Mice ; Mice, Transgenic ; Motor Neurons/*physiology ; Nerve Tissue Proteins/genetics ; Proteins/metabolism ; RNA, Untranslated ; Spinal Cord/abnormalities/*cytology/physiology ; Spinal Cord Injuries/physiopathology ; Synapses/*physiology ; Transcription Factors/metabolism ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 130
    facet.materialart.
    Unknown
    Neuroscience. The imaginary mind of a mouse (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-03-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morris, Richard G M -- Takeuchi, Tomonori -- G0700447/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2012 Mar 23;335(6075):1455-6. doi: 10.1126/science.1220824.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Cognitive and Neural Systems, University. of Edinburgh, Edinburgh EH8 9JZ, Scotland, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22442473" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*physiology ; *Fear ; *Memory ; Neurons/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 131
    facet.materialart.
    Unknown
    Comment on "The geometric structure of the brain fiber pathways" (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-09-29
    Description: Wedeen et al. (Reports, 30 March 2012, p. 1628) proposed a geometrical grid pattern in the brain that could help the understanding of the brain's organization and connectivity. We show that whole-brain fiber crossing quantification does not support their theory. Our results suggest that the grid pattern is most likely an artifact attributable to the limitations of their method.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Catani, Marco -- Bodi, Istvan -- Dell'Acqua, Flavio -- P41 RR-023953/RR/NCRR NIH HHS/ -- P41 RR-14075/RR/NCRR NIH HHS/ -- R01-MH652456/MH/NIMH NIH HHS/ -- U01 MH093765/MH/NIMH NIH HHS/ -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2012 Sep 28;337(6102):1605.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉NATBRAINLAB, Department of Neuroimaging, Institute of Psychiatry, King's College London, London, UK. m.catani@iop.kcl.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23019632" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cerebral Cortex/*anatomy & histology ; Humans ; *Nerve Fibers ; Neural Pathways/*anatomy & histology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 132
    facet.materialart.
    Unknown
    Immunology. Remembering to be tolerant (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-02-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, June-Yong -- Jameson, Stephen C -- R37 AI038903/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2012 Feb 10;335(6069):667-8. doi: 10.1126/science.1218927.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55414, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22323808" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; CD8-Positive T-Lymphocytes/*immunology ; Lymphopenia/*immunology ; *Self Tolerance
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 133
    facet.materialart.
    Unknown
    Indoor ecosystems (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-02-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Humphries, Courtney -- New York, N.Y. -- Science. 2012 Feb 10;335(6069):648-50. doi: 10.1126/science.335.6069.648.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22323793" target="_blank"〉PubMed〈/a〉
    Keywords: Air Microbiology ; Animals ; Bacteria/*isolation & purification ; Biodiversity ; Biota ; Databases, Genetic ; *Ecosystem ; *Environmental Microbiology ; Foundations ; Hospitals ; Housing ; Humans ; Metagenome ; Research Support as Topic ; Toilet Facilities ; Workplace
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 134
    facet.materialart.
    Unknown
    Epigenetic regulation by long noncoding RNAs (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-12-15
    Description: Recent studies show that transcription of the mammalian genome is not only pervasive but also enormously complex. It is estimated that an average of 10 transcription units, the vast majority of which make long noncoding RNAs (lncRNAs), may overlap each traditional coding gene. These lncRNAs include not only antisense, intronic, and intergenic transcripts but also pseudogenes and retrotransposons. Do they universally have function, or are they merely transcriptional by-products of conventional coding genes? A glimpse into the molecular biology of multiple emerging lncRNA systems reveals the "Wild West" landscape of their functions and mechanisms and the key problems to solve in the years ahead toward understanding these intriguing macromolecules.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, Jeannie T -- R01 GM058839/GM/NIGMS NIH HHS/ -- R37 GM058839/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2012 Dec 14;338(6113):1435-9. doi: 10.1126/science.1231776.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02138, USA. lee@molbio.mgh.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23239728" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Epigenesis, Genetic ; Genome/genetics ; Humans ; Pseudogenes/genetics ; RNA, Long Noncoding/*genetics ; Retroelements/genetics ; X Chromosome/genetics ; X Chromosome Inactivation/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 135
    facet.materialart.
    Unknown
    Molecular biology. EZH2 goes solo (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-12-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cavalli, Giacomo -- New York, N.Y. -- Science. 2012 Dec 14;338(6113):1430-1. doi: 10.1126/science.1232332.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut de Genetique Humaine, CNRS, 141 rue de la Cardonille, 34396 Montpellier, France. giacomo.cavalli@igh.cnrs.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23239724" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Humans ; Male ; Oncogene Proteins/*metabolism ; Polycomb Repressive Complex 2/*metabolism ; Prostatic Neoplasms/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 136
    facet.materialart.
    Unknown
    Water management. Water sustainability for China and beyond (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-08-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, Jianguo -- Yang, Wu -- New York, N.Y. -- Science. 2012 Aug 10;337(6095):649-50. doi: 10.1126/science.1219471.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Systems Integration and Sustainability, Michigan State University, East Lansing, MI 48824, USA. liuji@msu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22879488" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture ; Animals ; China ; *Conservation of Natural Resources ; Ecosystem ; Environmental Monitoring ; Humans ; International Cooperation ; Population Growth ; *Public Policy ; *Water ; Water Pollution ; Water Quality ; *Water Supply
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 137
    facet.materialart.
    Unknown
    A core metabolic enzyme mediates resistance to phosphine gas (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-11-10
    Description: Phosphine is a small redox-active gas that is used to protect global grain reserves, which are threatened by the emergence of phosphine resistance in pest insects. We find that polymorphisms responsible for genetic resistance cluster around the redox-active catalytic disulfide or the dimerization interface of dihydrolipoamide dehydrogenase (DLD) in insects (Rhyzopertha dominica and Tribolium castaneum) and nematodes (Caenorhabditis elegans). DLD is a core metabolic enzyme representing a new class of resistance factor for a redox-active metabolic toxin. It participates in four key steps of core metabolism, and metabolite profiles indicate that phosphine exposure in mutant and wild-type animals affects these steps differently. Mutation of DLD in C. elegans increases arsenite sensitivity. This specific vulnerability may be exploited to control phosphine-resistant insects and safeguard food security.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schlipalius, David I -- Valmas, Nicholas -- Tuck, Andrew G -- Jagadeesan, Rajeswaran -- Ma, Li -- Kaur, Ramandeep -- Goldinger, Anita -- Anderson, Cameron -- Kuang, Jujiao -- Zuryn, Steven -- Mau, Yosep S -- Cheng, Qiang -- Collins, Patrick J -- Nayak, Manoj K -- Schirra, Horst Joachim -- Hilliard, Massimo A -- Ebert, Paul R -- R01NS060129/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2012 Nov 9;338(6108):807-10. doi: 10.1126/science.1224951.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Agri-Science Queensland, Department of Agriculture, Fisheries and Forestry, Ecosciences Precinct, Brisbane, QLD 4001, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23139334" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arsenicals/pharmacology ; Arsenites/pharmacology ; Beetles/drug effects/*enzymology/genetics/metabolism ; Caenorhabditis elegans/drug effects/*enzymology/genetics/metabolism ; Caenorhabditis elegans Proteins/chemistry/genetics/metabolism ; Catalytic Domain ; Dihydrolipoamide Dehydrogenase/chemistry/*genetics/metabolism ; Insect Proteins/chemistry/genetics/metabolism ; Insecticide Resistance/*genetics ; *Insecticides/pharmacology ; Metabolic Networks and Pathways ; Molecular Sequence Data ; Mutation ; Oxidation-Reduction ; Pesticides ; *Phosphines/pharmacology ; Polymorphism, Genetic ; Protein Multimerization ; Tribolium/drug effects/*enzymology/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 138
    facet.materialart.
    Unknown
    Virology. A henipavirus vaccine in sight (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-08-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉von Messling, Veronika -- Cattaneo, Roberto -- New York, N.Y. -- Science. 2012 Aug 10;337(6095):651-2. doi: 10.1126/science.1227810.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Emerging Infectious Disease Program, Duke-NUS Graduate Medical School Singapore, 169857 Singapore. veronika.vonmessling@duke-nus.edu.sg〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22879489" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disease Outbreaks/prevention & control/veterinary ; Hendra Virus/*immunology ; Henipavirus Infections/epidemiology/*prevention & control/veterinary ; Humans ; Nipah Virus/*immunology ; Vaccines, Subunit ; Viral Envelope Proteins/*immunology ; Viral Proteins/immunology ; *Viral Vaccines
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 139
    facet.materialart.
    Unknown
    Comment on "Levy walks evolve through interaction between movement and environmental complexity" (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-03-01
    Description: de Jager et al. (Reports, 24 June 2011, p. 1551) concluded that mussels Levy walk. We confronted a larger model set with these data and found that mussels do not Levy walk: Their movement is best described by a composite Brownian walk. This shows how model selection based on an impoverished set of candidate models can lead to incorrect inferences.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jansen, Vincent A A -- Mashanova, Alla -- Petrovskii, Sergei -- BB/G007934/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- New York, N.Y. -- Science. 2012 Feb 24;335(6071):918; author reply 918. doi: 10.1126/science.1215747.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Biological Sciences, Royal Holloway, University of London, Surrey TW20 0EX, UK. vincent.jansen@rhul.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22362991" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; *Ecosystem ; Mytilus edulis/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 140
    facet.materialart.
    Unknown
    Evolution. Efficiency in evolutionary trade-offs (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Noor, Elad -- Milo, Ron -- New York, N.Y. -- Science. 2012 Jun 1;336(6085):1114-5. doi: 10.1126/science.1223193.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Plant Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22654045" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacteria/*metabolism ; *Biological Evolution ; Escherichia coli/*metabolism ; *Genetic Fitness ; *Metabolic Networks and Pathways ; *Phenotype
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 141
    facet.materialart.
    Unknown
    Centrosome loss in the evolution of planarians (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-01-10
    Description: The centrosome, a cytoplasmic organelle formed by cylinder-shaped centrioles surrounded by a microtubule-organizing matrix, is a hallmark of animal cells. The centrosome is conserved and essential for the development of all animal species described so far. Here, we show that planarians, and possibly other flatworms, lack centrosomes. In planarians, centrioles are only assembled in terminally differentiating ciliated cells through the acentriolar pathway to trigger the assembly of cilia. We identified a large set of conserved proteins required for centriole assembly in animals and note centrosome protein families that are missing from the planarian genome. Our study uncovers the molecular architecture and evolution of the animal centrosome and emphasizes the plasticity of animal cell biology and development.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347778/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347778/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Azimzadeh, Juliette -- Wong, Mei Lie -- Downhour, Diane Miller -- Sanchez Alvarado, Alejandro -- Marshall, Wallace F -- GM077004/GM/NIGMS NIH HHS/ -- GM57260/GM/NIGMS NIH HHS/ -- R01 GM057260/GM/NIGMS NIH HHS/ -- R01 GM077004/GM/NIGMS NIH HHS/ -- R37 GM057260/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2012 Jan 27;335(6067):461-3. doi: 10.1126/science.1214457. Epub 2012 Jan 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Biophysics, University of California-San Francisco, CA 94143, USA. juliette.azimzadeh@ucsf.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22223737" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Centrioles/metabolism/ultrastructure ; *Centrosome/metabolism/ultrastructure ; Cilia/metabolism/ultrastructure ; Genome, Helminth ; Helminth Proteins/*genetics/metabolism ; Movement ; Phenotype ; Planarians/*genetics/physiology/*ultrastructure ; RNA Interference ; Regeneration ; Selection, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 142
    facet.materialart.
    Unknown
    Heavy livestock grazing promotes locust outbreaks by lowering plant nitrogen content (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-01-28
    Description: Current paradigms generally assume that increased plant nitrogen (N) should enhance herbivore performance by relieving protein limitation, increasing herbivorous insect populations. We show, in contrast to this scenario, that host plant N enrichment and high-protein artificial diets decreased the size and viability of Oedaleus asiaticus, a dominant locust of north Asian grasslands. This locust preferred plants with low N content and artificial diets with low protein and high carbohydrate content. Plant N content was lowest and locust abundance highest in heavily livestock-grazed fields where soils were N-depleted, likely due to enhanced erosion. These results suggest that heavy livestock grazing and consequent steppe degradation in the Eurasian grassland promote outbreaks of this locust by reducing plant protein content.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cease, Arianne J -- Elser, James J -- Ford, Colleen F -- Hao, Shuguang -- Kang, Le -- Harrison, Jon F -- New York, N.Y. -- Science. 2012 Jan 27;335(6067):467-9. doi: 10.1126/science.1214433.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA. arianne.cease@asu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22282812" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Husbandry ; Animals ; Biomass ; Diet ; Dietary Proteins/administration & dosage ; *Ecosystem ; Feeding Behavior ; Fertilizers ; Food Preferences ; Grasshoppers/growth & development/*physiology ; Herbivory/physiology ; *Livestock ; Nitrogen/*analysis ; Plant Proteins/*analysis ; Plants/*chemistry ; Poaceae/chemistry/growth & development ; Population Dynamics ; Sheep
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 143
    facet.materialart.
    Unknown
    Natural SIV hosts: showing AIDS the door (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-03-10
    Description: Many species of African nonhuman primates are naturally infected with simian immunodeficiency viruses (SIVs) in the wild and in captivity. In contrast to HIV-infected humans, these natural SIV hosts typically do not develop AIDS, despite chronic infection with a highly replicating virus. In this Review, we discuss the most recent advances on the mechanisms of protection from disease progression in natural SIV hosts, with emphasis on how they differ from pathogenic HIV/SIV infections of humans and rhesus macaques. These mechanisms include: (i) resolution of immune activation after acute infection, (ii) restricted pattern of target cell infection, and (iii) protection from mother-to-infant transmission. We highlight the areas that should be pursued in future studies, focusing on potential applications for the treatment and prevention of HIV infection.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822437/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822437/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chahroudi, Ann -- Bosinger, Steven E -- Vanderford, Thomas H -- Paiardini, Mirko -- Silvestri, Guido -- P51-RR00165/RR/NCRR NIH HHS/ -- R01 AI066998/AI/NIAID NIH HHS/ -- R01 AI084836/AI/NIAID NIH HHS/ -- R01-AI066998/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2012 Mar 9;335(6073):1188-93. doi: 10.1126/science.1217550.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22403383" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptive Immunity ; Animals ; CD4-Positive T-Lymphocytes/immunology/virology ; Cercocebus atys ; Cercopithecus aethiops ; Disease Progression ; Female ; HIV Infections/immunology/transmission/virology ; Host-Pathogen Interactions ; Humans ; Immunity, Innate ; Infectious Disease Transmission, Vertical ; Simian Acquired Immunodeficiency Syndrome/*immunology/transmission/*virology ; *Simian Immunodeficiency Virus/immunology/pathogenicity/physiology ; T-Lymphocyte Subsets/immunology/virology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 144
    facet.materialart.
    Unknown
    Global endemism needs spatial integration (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-01-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lei, Fu-Min -- New York, N.Y. -- Science. 2012 Jan 20;335(6066):284-5; author reply 285-6. doi: 10.1126/science.335.6066.284-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22267791" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biodiversity ; *Climate Change
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 145
    facet.materialart.
    Unknown
    China's push in tissue engineering (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-11-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hvistendahl, Mara -- New York, N.Y. -- Science. 2012 Nov 16;338(6109):900-2. doi: 10.1126/science.338.6109.900.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23161989" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; China ; Government Programs ; Humans ; Mice ; Nerve Regeneration ; Peripheral Nerves/physiology/transplantation ; Tissue Engineering/*economics/*trends
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 146
    facet.materialart.
    Unknown
    Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-05-15
    Description: Human UBIAD1 localizes to mitochondria and converts vitamin K(1) to vitamin K(2). Vitamin K(2) is best known as a cofactor in blood coagulation, but in bacteria it is a membrane-bound electron carrier. Whether vitamin K(2) exerts a similar carrier function in eukaryotic cells is unknown. We identified Drosophila UBIAD1/Heix as a modifier of pink1, a gene mutated in Parkinson's disease that affects mitochondrial function. We found that vitamin K(2) was necessary and sufficient to transfer electrons in Drosophila mitochondria. Heix mutants showed severe mitochondrial defects that were rescued by vitamin K(2), and, similar to ubiquinone, vitamin K(2) transferred electrons in Drosophila mitochondria, resulting in more efficient adenosine triphosphate (ATP) production. Thus, mitochondrial dysfunction was rescued by vitamin K(2) that serves as a mitochondrial electron carrier, helping to maintain normal ATP production.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vos, Melissa -- Esposito, Giovanni -- Edirisinghe, Janaka N -- Vilain, Sven -- Haddad, Dominik M -- Slabbaert, Jan R -- Van Meensel, Stefanie -- Schaap, Onno -- De Strooper, Bart -- Meganathan, R -- Morais, Vanessa A -- Verstreken, Patrik -- New York, N.Y. -- Science. 2012 Jun 8;336(6086):1306-10. doi: 10.1126/science.1218632. Epub 2012 May 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉VIB Center for the Biology of Disease, Leuven, Belgium.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22582012" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Animals ; Drosophila/genetics/*metabolism ; Drosophila Proteins/deficiency/*genetics/*metabolism ; *Electron Transport ; Escherichia coli/metabolism ; Flight, Animal ; Genes, Insect ; Membrane Potential, Mitochondrial ; Mitochondria/*metabolism/ultrastructure ; Mitochondria, Muscle/metabolism/ultrastructure ; Mutation ; Oxygen Consumption ; Protein-Serine-Threonine Kinases/deficiency/*genetics/*metabolism ; Ubiquinone/metabolism ; Ubiquitin-Protein Ligases/genetics ; Vitamin K 2/*metabolism/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 147
    facet.materialart.
    Unknown
    The connectome of a decision-making neural network (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-07-28
    Description: In order to understand the nervous system, it is necessary to know the synaptic connections between the neurons, yet to date, only the wiring diagram of the adult hermaphrodite of the nematode Caenorhabditis elegans has been determined. Here, we present the wiring diagram of the posterior nervous system of the C. elegans adult male, reconstructed from serial electron micrograph sections. This region of the male nervous system contains the sexually dimorphic circuits for mating. The synaptic connections, both chemical and gap junctional, form a neural network with four striking features: multiple, parallel, short synaptic pathways directly connecting sensory neurons to end organs; recurrent and reciprocal connectivity among sensory neurons; modular substructure; and interneurons acting in feedforward loops. These features help to explain how the network robustly and rapidly selects and executes the steps of a behavioral program on the basis of the inputs from multiple sensory neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jarrell, Travis A -- Wang, Yi -- Bloniarz, Adam E -- Brittin, Christopher A -- Xu, Meng -- Thomson, J Nichol -- Albertson, Donna G -- Hall, David H -- Emmons, Scott W -- OD 010943/OD/NIH HHS/ -- R21MH63223/MH/NIMH NIH HHS/ -- Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2012 Jul 27;337(6093):437-44. doi: 10.1126/science.1221762.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22837521" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Caenorhabditis elegans/*physiology/*ultrastructure ; Electrical Synapses/physiology/ultrastructure ; Hermaphroditic Organisms ; Image Processing, Computer-Assisted ; Interneurons/physiology/ultrastructure ; Male ; Microscopy, Electron ; Motor Neurons/physiology/ultrastructure ; Muscles/innervation/physiology ; Nerve Net/*physiology/*ultrastructure ; Neuromuscular Junction/physiology/ultrastructure ; Neurons/*physiology/ultrastructure ; Sensory Receptor Cells/physiology/ultrastructure ; *Sexual Behavior, Animal ; Synapses/*physiology/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 148
    facet.materialart.
    Unknown
    Clovis age Western Stemmed projectile points and human coprolites at the Paisley Caves (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-07-17
    Description: The Paisley Caves in Oregon record the oldest directly dated human remains (DNA) in the Western Hemisphere. More than 100 high-precision radiocarbon dates show that deposits containing artifacts and coprolites ranging in age from 12,450 to 2295 (14)C years ago are well stratified. Western Stemmed projectile points were recovered in deposits dated to 11,070 to 11,340 (14)C years ago, a time contemporaneous with or preceding the Clovis technology. There is no evidence of diagnostic Clovis technology at the site. These two distinct technologies were parallel developments, not the product of a unilinear technological evolution. "Blind testing" analysis of coprolites by an independent laboratory confirms the presence of human DNA in specimens of pre-Clovis age. The colonization of the Americas involved multiple technologically divergent, and possibly genetically divergent, founding groups.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jenkins, Dennis L -- Davis, Loren G -- Stafford, Thomas W Jr -- Campos, Paula F -- Hockett, Bryan -- Jones, George T -- Cummings, Linda Scott -- Yost, Chad -- Connolly, Thomas J -- Yohe, Robert M 2nd -- Gibbons, Summer C -- Raghavan, Maanasa -- Rasmussen, Morten -- Paijmans, Johanna L A -- Hofreiter, Michael -- Kemp, Brian M -- Barta, Jodi Lynn -- Monroe, Cara -- Gilbert, M Thomas P -- Willerslev, Eske -- New York, N.Y. -- Science. 2012 Jul 13;337(6091):223-8. doi: 10.1126/science.1218443.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Museum of Natural and Cultural History, University of Oregon, Eugene, OR 97403, USA. djenkins@uoregon.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22798611" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Archaeology ; *Caves ; DNA/analysis ; Emigration and Immigration/history ; Feces ; *Fossils ; History, Ancient ; Humans ; Molecular Sequence Data ; North America ; Oregon ; Population Dynamics ; Radiometric Dating ; Rodentia ; Technology/history ; Time
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 149
    facet.materialart.
    Unknown
    The pulvinar regulates information transmission between cortical areas based on attention demands (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-08-11
    Description: Selective attention mechanisms route behaviorally relevant information through large-scale cortical networks. Although evidence suggests that populations of cortical neurons synchronize their activity to preferentially transmit information about attentional priorities, it is unclear how cortical synchrony across a network is accomplished. Based on its anatomical connectivity with the cortex, we hypothesized that the pulvinar, a thalamic nucleus, regulates cortical synchrony. We mapped pulvino-cortical networks within the visual system, using diffusion tensor imaging, and simultaneously recorded spikes and field potentials from these interconnected network sites in monkeys performing a visuospatial attention task. The pulvinar synchronized activity between interconnected cortical areas according to attentional allocation, suggesting a critical role for the thalamus not only in attentional selection but more generally in regulating information transmission across the visual cortex.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714098/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714098/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Saalmann, Yuri B -- Pinsk, Mark A -- Wang, Liang -- Li, Xin -- Kastner, Sabine -- R01 EY017699/EY/NEI NIH HHS/ -- R21 EY021078/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 2012 Aug 10;337(6095):753-6. doi: 10.1126/science.1223082.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA. saalmann@princeton.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22879517" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; *Attention ; Brain Mapping ; *Cortical Synchronization ; Cues ; Diffusion Tensor Imaging ; Macaca fascicularis ; Male ; Nerve Net/*physiology ; Neurons/physiology ; Pulvinar/cytology/*physiology ; Space Perception ; Visual Cortex/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 150
    facet.materialart.
    Unknown
    Genetics. A genetic intervention stands a skip away from clinical tests (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-12-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chamberlain, Jeffrey S -- R37 AR040864/AR/NIAMS NIH HHS/ -- New York, N.Y. -- Science. 2012 Dec 14;338(6113):1431-2. doi: 10.1126/science.1233074.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurology, School of Medicine, University of Washington, 1959 N.E. Pacific Street, Seattle, WA 98195-7720, USA. Jsc5@u.washington.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23239725" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium Channel Blockers/administration & dosage/therapeutic use ; Clinical Trials as Topic ; Dantrolene/administration & dosage/*therapeutic use ; Disease Models, Animal ; Dystrophin/*biosynthesis/genetics ; Exons/genetics ; Mice ; Muscle Relaxants, Central/administration & dosage/*therapeutic use ; Muscular Dystrophy, Duchenne/genetics/*therapy ; Oligonucleotides, Antisense/administration & dosage/*therapeutic use ; RNA Precursors/genetics ; Ryanodine Receptor Calcium Release Channel/metabolism ; Sequence Deletion
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 151
    facet.materialart.
    Unknown
    Marine conservation. Oh, baby: fight brews over U.S. import of beluga whales (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-10-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Underwood, Emily -- New York, N.Y. -- Science. 2012 Oct 12;338(6104):180. doi: 10.1126/science.338.6104.180.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23066051" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Beluga Whale ; *Endangered Species ; Russia ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 152
    facet.materialart.
    Unknown
    How cells know the size of their organelles (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-09-08
    Description: Cells have developed ways to sense and control the size of their organelles. Size-sensing mechanisms range from direct measurements provided by dedicated reporters to indirect functional readouts, and they are used to modify organelle size under both normal and stress conditions. Organelle size can also be controlled in the absence of an identifiable size sensor. Studies on flagella have dissected principles of size sensing and control, and it will be exciting to see how these principles apply to other organelles.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625396/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625396/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chan, Yee-Hung M -- Marshall, Wallace F -- 1F32GM090442-01A1/GM/NIGMS NIH HHS/ -- P50 GM081879/GM/NIGMS NIH HHS/ -- P50GM081879/GM/NIGMS NIH HHS/ -- R01 GM097017/GM/NIGMS NIH HHS/ -- R01GM097017/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2012 Sep 7;337(6099):1186-9. doi: 10.1126/science.1223539.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Biophysics, UCSF Center for Systems and Synthetic Biology, University of California, San Francisco, San Francisco, CA 94158, USA. yhmchan@ucsf.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22955827" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport ; *Cell Physiological Phenomena ; Flagella/metabolism/physiology/ultrastructure ; Humans ; Models, Biological ; *Organelle Size ; *Organelles/chemistry/metabolism/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 153
    facet.materialart.
    Unknown
    Adaptive sleep loss in polygynous pectoral sandpipers (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-08-11
    Description: The functions of sleep remain elusive. Extensive evidence suggests that sleep performs restorative processes that sustain waking brain performance. An alternative view proposes that sleep simply enforces adaptive inactivity to conserve energy when activity is unproductive. Under this hypothesis, animals may evolve the ability to dispense with sleep when ecological demands favor wakefulness. Here, we show that male pectoral sandpipers (Calidris melanotos), a polygynous Arctic breeding shorebird, are able to maintain high neurobehavioral performance despite greatly reducing their time spent sleeping during a 3-week period of intense male-male competition for access to fertile females. Males that slept the least sired the most offspring. Our results challenge the view that decreased performance is an inescapable outcome of sleep loss.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lesku, John A -- Rattenborg, Niels C -- Valcu, Mihai -- Vyssotski, Alexei L -- Kuhn, Sylvia -- Kuemmeth, Franz -- Heidrich, Wolfgang -- Kempenaers, Bart -- New York, N.Y. -- Science. 2012 Sep 28;337(6102):1654-8. Epub 2012 Aug 9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Avian Sleep Group, Max Planck Institute for Ornithology, Seewiesen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22878501" target="_blank"〉PubMed〈/a〉
    Keywords: *Adaptation, Physiological ; Animals ; Charadriiformes/*physiology ; Energy Metabolism ; Female ; Male ; *Reproduction ; *Sexual Behavior, Animal ; Sleep/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 154
    facet.materialart.
    Unknown
    Using gene expression noise to understand gene regulation (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-04-14
    Description: Phenotypic variation is ubiquitous in biology and is often traceable to underlying genetic and environmental variation. However, even genetically identical cells in identical environments display variable phenotypes. Stochastic gene expression, or gene expression "noise," has been suggested as a major source of this variability, and its physiological consequences have been topics of intense research for the last decade. Several recent studies have measured variability in protein and messenger RNA levels, and they have discovered strong connections between noise and gene regulation mechanisms. When integrated with discrete stochastic models, measurements of cell-to-cell variability provide a sensitive "fingerprint" with which to explore fundamental questions of gene regulation. In this review, we highlight several studies that used gene expression variability to develop a quantitative understanding of the mechanisms and dynamics of gene regulation.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358231/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358231/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Munsky, Brian -- Neuert, Gregor -- van Oudenaarden, Alexander -- 1DP1OD003936/OD/NIH HHS/ -- DP1 CA174420/CA/NCI NIH HHS/ -- DP1 OD003936/OD/NIH HHS/ -- New York, N.Y. -- Science. 2012 Apr 13;336(6078):183-7. doi: 10.1126/science.1216379.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Nonlinear Studies, the National Flow Cytometry Resource, Los Alamos National Laboratory, Los Alamos, NM 87545, USA. munsky@lanl.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22499939" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Gene Expression ; *Gene Expression Regulation ; Humans ; *Models, Genetic ; Models, Statistical ; Phenotype ; RNA, Messenger/genetics/metabolism ; Stochastic Processes ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 155
    facet.materialart.
    Unknown
    Pigs as stand-ins for microbiome studies (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hvistendahl, Mara -- New York, N.Y. -- Science. 2012 Jun 8;336(6086):1250. doi: 10.1126/science.336.6086.1250. Epub 2012 Jun 6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22674332" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacteroides/growth & development ; Bifidobacterium/growth & development ; Gastrointestinal Tract/*microbiology ; Humans ; *Metagenome ; *Models, Animal ; Swine/genetics/*microbiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 156
    facet.materialart.
    Unknown
    My microbiome and me (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hvistendahl, Mara -- New York, N.Y. -- Science. 2012 Jun 8;336(6086):1248-50. doi: 10.1126/science.336.6086.1248. Epub 2012 Jun 6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22674327" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacteria/*growth & development/metabolism ; Berberine/therapeutic use ; China ; Diet ; Drugs, Chinese Herbal/*therapeutic use ; Gastrointestinal Tract/*microbiology ; History, 20th Century ; History, 21st Century ; Humans ; Mice ; Obesity/diet therapy/drug therapy/*microbiology/*therapy ; Prebiotics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 157
    facet.materialart.
    Unknown
    IRE1alpha cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2 (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-10-09
    Description: The endoplasmic reticulum (ER) is the primary organelle for folding and maturation of secretory and transmembrane proteins. Inability to meet protein-folding demand leads to "ER stress," and activates IRE1alpha, an ER transmembrane kinase-endoribonuclease (RNase). IRE1alpha promotes adaptation through splicing Xbp1 mRNA or apoptosis through incompletely understood mechanisms. Here, we found that sustained IRE1alpha RNase activation caused rapid decay of select microRNAs (miRs -17, -34a, -96, and -125b) that normally repress translation of Caspase-2 mRNA, and thus sharply elevates protein levels of this initiator protease of the mitochondrial apoptotic pathway. In cell-free systems, recombinant IRE1alpha endonucleolytically cleaved microRNA precursors at sites distinct from DICER. Thus, IRE1alpha regulates translation of a proapoptotic protein through terminating microRNA biogenesis, and noncoding RNAs are part of the ER stress response.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742121/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742121/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Upton, John-Paul -- Wang, Likun -- Han, Dan -- Wang, Eric S -- Huskey, Noelle E -- Lim, Lionel -- Truitt, Morgan -- McManus, Michael T -- Ruggero, Davide -- Goga, Andrei -- Papa, Feroz R -- Oakes, Scott A -- DK063720/DK/NIDDK NIH HHS/ -- DP2 OD001925/OD/NIH HHS/ -- DP2OD001925/OD/NIH HHS/ -- GM080783/GM/NIGMS NIH HHS/ -- P30 DK063720/DK/NIDDK NIH HHS/ -- R01 CA136577/CA/NCI NIH HHS/ -- R01 CA136717/CA/NCI NIH HHS/ -- R01 CA140456/CA/NCI NIH HHS/ -- R01 CA154916/CA/NCI NIH HHS/ -- R01 DK080955/DK/NIDDK NIH HHS/ -- R01 GM080783/GM/NIGMS NIH HHS/ -- R01CA136577/CA/NCI NIH HHS/ -- R01CA136717/CA/NCI NIH HHS/ -- R01CA140456/CA/NCI NIH HHS/ -- R01CA154916/CA/NCI NIH HHS/ -- R01DK080955/DK/NIDDK NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2012 Nov 9;338(6108):818-22. doi: 10.1126/science.1226191. Epub 2012 Oct 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23042294" target="_blank"〉PubMed〈/a〉
    Keywords: 3' Untranslated Regions ; Animals ; Apoptosis ; Brefeldin A/pharmacology ; Caspase 2/*genetics/*metabolism ; Cell-Free System ; Cells, Cultured ; Cysteine Endopeptidases/*genetics/*metabolism ; Down-Regulation ; Endoplasmic Reticulum/metabolism ; *Endoplasmic Reticulum Stress ; Endoribonucleases/chemistry/genetics/*metabolism ; Enzyme Activation ; HEK293 Cells ; Humans ; Mice ; Mice, Knockout ; MicroRNAs/*metabolism ; Mutant Proteins ; Protein Biosynthesis ; Protein-Serine-Threonine Kinases/chemistry/genetics/*metabolism ; RNA Stability ; RNA, Messenger/genetics/metabolism ; Up-Regulation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 158
    facet.materialart.
    Unknown
    Mechanism of voltage gating in potassium channels (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-04-14
    Description: The mechanism of ion channel voltage gating-how channels open and close in response to voltage changes-has been debated since Hodgkin and Huxley's seminal discovery that the crux of nerve conduction is ion flow across cellular membranes. Using all-atom molecular dynamics simulations, we show how a voltage-gated potassium channel (KV) switches between activated and deactivated states. On deactivation, pore hydrophobic collapse rapidly halts ion flow. Subsequent voltage-sensing domain (VSD) relaxation, including inward, 15-angstrom S4-helix motion, completes the transition. On activation, outward S4 motion tightens the VSD-pore linker, perturbing linker-S6-helix packing. Fluctuations allow water, then potassium ions, to reenter the pore; linker-S6 repacking stabilizes the open pore. We propose a mechanistic model for the sodium/potassium/calcium voltage-gated ion channel superfamily that reconciles apparently conflicting experimental data.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jensen, Morten O -- Jogini, Vishwanath -- Borhani, David W -- Leffler, Abba E -- Dror, Ron O -- Shaw, David E -- New York, N.Y. -- Science. 2012 Apr 13;336(6078):229-33. doi: 10.1126/science.1216533.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉D E Shaw Research, New York, NY 10036, USA. morten.jensen@DEShawResearch.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22499946" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Hydrophobic and Hydrophilic Interactions ; *Ion Channel Gating ; Kv1.2 Potassium Channel/*chemistry/*metabolism ; Membrane Potentials ; Models, Biological ; Models, Molecular ; Molecular Dynamics Simulation ; Protein Conformation ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Rats ; Recombinant Fusion Proteins/chemistry/metabolism ; Shab Potassium Channels/*chemistry/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 159
    facet.materialart.
    Unknown
    Retrospective. Norman L. Letvin (1949-2012) (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nabel, Gary J -- Wolinsky, Steven M -- Haynes, Barton F -- New York, N.Y. -- Science. 2012 Jun 29;336(6089):1653. doi: 10.1126/science.1225947.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, MD 20892, USA. gnabel@nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22745414" target="_blank"〉PubMed〈/a〉
    Keywords: AIDS Vaccines/*history ; Acquired Immunodeficiency Syndrome/*history ; Animals ; History, 20th Century ; History, 21st Century ; Humans ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 160
    facet.materialart.
    Unknown
    Avian influenza. For young scientists, a wild ride (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- New York, N.Y. -- Science. 2012 Jun 22;336(6088):1495. doi: 10.1126/science.336.6088.1495.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22723388" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cough ; Ferrets ; *Influenza A Virus, H5N1 Subtype/genetics/pathogenicity ; Mutation ; Orthomyxoviridae Infections/transmission/*virology ; Publishing ; *Research Personnel ; Sneezing
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 161
    facet.materialart.
    Unknown
    Avian influenza. Public at last, H5N1 study offers insight into virus's possible path to pandemic (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- New York, N.Y. -- Science. 2012 Jun 22;336(6088):1494-7. doi: 10.1126/science.336.6088.1494.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22723387" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Evolution, Molecular ; Female ; *Ferrets ; Hemagglutinin Glycoproteins, Influenza Virus/*genetics ; Humans ; Influenza A Virus, H5N1 Subtype/*genetics/*pathogenicity ; Influenza, Human/*virology ; Orthomyxoviridae Infections/*virology ; RNA Replicase/*genetics ; Respiratory System/*virology ; Viral Proteins/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 162
    facet.materialart.
    Unknown
    India. Field biologists cry foul over ban (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-03-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bagla, Pallava -- New York, N.Y. -- Science. 2012 Mar 23;335(6075):1429. doi: 10.1126/science.335.6075.1429.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22442454" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Wild ; *Biology ; *Conservation of Natural Resources/legislation & jurisprudence ; Endangered Species ; India ; *Research ; *Tigers
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 163
    facet.materialart.
    Unknown
    Religiously protecting Myanmar's environment (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-09-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chong, Kwek Y -- New York, N.Y. -- Science. 2012 Sep 28;337(6102):1604-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23019628" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biodiversity ; Conservation of Natural Resources/*economics ; *Endangered Species ; *Environment ; *Investments ; *Trees
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 164
    facet.materialart.
    Unknown
    Depth perception from image defocus in a jumping spider (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-01-28
    Description: The principal eyes of jumping spiders have a unique retina with four tiered photoreceptor layers, on each of which light of different wavelengths is focused by a lens with appreciable chromatic aberration. We found that all photoreceptors in both the deepest and second-deepest layers contain a green-sensitive visual pigment, although green light is only focused on the deepest layer. This mismatch indicates that the second-deepest layer always receives defocused images, which contain depth information of the scene in optical theory. Behavioral experiments revealed that depth perception in the spider was affected by the wavelength of the illuminating light, which affects the amount of defocus in the images resulting from chromatic aberration. Therefore, we propose a depth perception mechanism based on how much the retinal image is defocused.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nagata, Takashi -- Koyanagi, Mitsumasa -- Tsukamoto, Hisao -- Saeki, Shinjiro -- Isono, Kunio -- Shichida, Yoshinori -- Tokunaga, Fumio -- Kinoshita, Michiyo -- Arikawa, Kentaro -- Terakita, Akihisa -- New York, N.Y. -- Science. 2012 Jan 27;335(6067):469-71. doi: 10.1126/science.1211667.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology and Geosciences, Graduate School of Science, Osaka City University, Osaka, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22282813" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cues ; Depth Perception ; Fixation, Ocular ; Light ; Locomotion ; Opsins/analysis/physiology ; Photoreceptor Cells, Invertebrate/chemistry/*physiology ; Predatory Behavior ; Spiders/*physiology ; Vision, Ocular
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 165
    facet.materialart.
    Unknown
    A stem cell-based approach to cartilage repair (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-04-12
    Description: Osteoarthritis (OA) is a degenerative joint disease that involves the destruction of articular cartilage and eventually leads to disability. Molecules that promote the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes may stimulate the repair of damaged cartilage. Using an image-based high-throughput screen, we identified the small molecule kartogenin, which promotes chondrocyte differentiation (median effective concentration = 100 nM), shows chondroprotective effects in vitro, and is efficacious in two OA animal models. Kartogenin binds filamin A, disrupts its interaction with the transcription factor core-binding factor beta subunit (CBFbeta), and induces chondrogenesis by regulating the CBFbeta-RUNX1 transcriptional program. This work provides new insights into the control of chondrogenesis that may ultimately lead to a stem cell-based therapy for osteoarthritis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Johnson, Kristen -- Zhu, Shoutian -- Tremblay, Matthew S -- Payette, Joshua N -- Wang, Jianing -- Bouchez, Laure C -- Meeusen, Shelly -- Althage, Alana -- Cho, Charles Y -- Wu, Xu -- Schultz, Peter G -- New York, N.Y. -- Science. 2012 May 11;336(6082):717-21. doi: 10.1126/science.1215157. Epub 2012 Apr 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA. kjohnson@gnf.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22491093" target="_blank"〉PubMed〈/a〉
    Keywords: Anilides/administration & dosage/chemistry/*pharmacology/therapeutic use ; Animals ; Cartilage, Articular/*cytology ; Cattle ; Cell Nucleus/metabolism ; Chondrocytes/cytology/*drug effects/metabolism/physiology ; *Chondrogenesis ; Contractile Proteins/metabolism ; Core Binding Factor Alpha 2 Subunit/metabolism ; Core Binding Factor beta Subunit/metabolism ; Disease Models, Animal ; Filamins ; High-Throughput Screening Assays ; Humans ; Mesenchymal Stromal Cells/cytology/*drug effects/physiology ; Mice ; Microfilament Proteins/metabolism ; Osteoarthritis/*drug therapy/pathology/physiopathology ; Phthalic Acids/administration & dosage/chemistry/*pharmacology/therapeutic use ; Regeneration ; Small Molecule Libraries ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 166
    facet.materialart.
    Unknown
    Molecular biology. Epigenetic islands in a genetic ocean (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-11-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schubeler, Dirk -- New York, N.Y. -- Science. 2012 Nov 9;338(6108):756-7. doi: 10.1126/science.1227243.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland. dirk@fmi.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23139324" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding Sites ; *CpG Islands ; *DNA Methylation ; DNA-Binding Proteins/metabolism ; Enhancer Elements, Genetic ; *Epigenesis, Genetic ; *Gene Expression Regulation ; Humans ; Promoter Regions, Genetic ; Transcription Factors/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 167
    facet.materialart.
    Unknown
    Photoacoustic tomography: in vivo imaging from organelles to organs (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-03-24
    Description: Photoacoustic tomography (PAT) can create multiscale multicontrast images of living biological structures ranging from organelles to organs. This emerging technology overcomes the high degree of scattering of optical photons in biological tissue by making use of the photoacoustic effect. Light absorption by molecules creates a thermally induced pressure jump that launches ultrasonic waves, which are received by acoustic detectors to form images. Different implementations of PAT allow the spatial resolution to be scaled with the desired imaging depth in tissue while a high depth-to-resolution ratio is maintained. As a rule of thumb, the achievable spatial resolution is on the order of 1/200 of the desired imaging depth, which can reach up to 7 centimeters. PAT provides anatomical, functional, metabolic, molecular, and genetic contrasts of vasculature, hemodynamics, oxygen metabolism, biomarkers, and gene expression. We review the state of the art of PAT for both biological and clinical studies and discuss future prospects.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322413/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322413/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, Lihong V -- Hu, Song -- R01 CA134539/CA/NCI NIH HHS/ -- R01 CA134539-04/CA/NCI NIH HHS/ -- R01 CA157277/CA/NCI NIH HHS/ -- R01 CA157277-02/CA/NCI NIH HHS/ -- R01 CA159959/CA/NCI NIH HHS/ -- R01 CA159959-01/CA/NCI NIH HHS/ -- R01 EB000712/EB/NIBIB NIH HHS/ -- R01 EB000712-09/EB/NIBIB NIH HHS/ -- R01 EB008085/EB/NIBIB NIH HHS/ -- R01 EB008085-04/EB/NIBIB NIH HHS/ -- R01 EB010049/EB/NIBIB NIH HHS/ -- R01 EB010049-03/EB/NIBIB NIH HHS/ -- U54 CA136398/CA/NCI NIH HHS/ -- U54 CA136398-05/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2012 Mar 23;335(6075):1458-62. doi: 10.1126/science.1216210.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University, St. Louis, MO 63130, USA. lhwang@wustl.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22442475" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Physiological Processes ; Cells/ultrastructure ; Genetic Processes ; Humans ; Lasers ; Organelles/ultrastructure ; *Photoacoustic Techniques/instrumentation/methods ; *Physiological Processes ; *Tomography/instrumentation/methods
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 168
    facet.materialart.
    Unknown
    Conservation. Challenges to the future conservation of the Antarctic (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-07-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chown, S L -- Lee, J E -- Hughes, K A -- Barnes, J -- Barrett, P J -- Bergstrom, D M -- Convey, P -- Cowan, D A -- Crosbie, K -- Dyer, G -- Frenot, Y -- Grant, S M -- Herr, D -- Kennicutt, M C 2nd -- Lamers, M -- Murray, A -- Possingham, H P -- Reid, K -- Riddle, M J -- Ryan, P G -- Sanson, L -- Shaw, J D -- Sparrow, M D -- Summerhayes, C -- Terauds, A -- Wall, D H -- New York, N.Y. -- Science. 2012 Jul 13;337(6091):158-9. doi: 10.1126/science.1222821.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Invasion Biology, Stellenbosch University, Matieland, South Africa. steven.chown@monash.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22798586" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antarctic Regions ; Climate Change ; *Conservation of Natural Resources/trends ; *Ecosystem ; Forecasting ; Human Activities ; Humans ; Public Policy ; Travel
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 169
    facet.materialart.
    Unknown
    Going to bat for an endangered species (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Florens, F B Vincent -- New York, N.Y. -- Science. 2012 Jun 1;336(6085):1102. doi: 10.1126/science.336.6085.1102-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22654040" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Chiroptera ; Conservation of Natural Resources/legislation & jurisprudence ; Ecosystem ; *Endangered Species/legislation & jurisprudence ; Mauritius
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 170
    facet.materialart.
    Unknown
    Evolution of language. Experiments probe language's origins and development (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-04-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Normile, Dennis -- New York, N.Y. -- Science. 2012 Apr 27;336(6080):408-11. doi: 10.1126/science.336.6080.408.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22539697" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Brain/*physiology ; Brain Mapping ; Cognition ; Computer Simulation ; *Cultural Evolution ; Finches ; Hominidae ; Humans ; *Language ; *Learning ; Linguistics ; Magnetic Resonance Imaging ; Tool Use Behavior ; Vocalization, Animal
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 171
    facet.materialart.
    Unknown
    Orbitofrontal cortex supports behavior and learning using inferred but not cached values (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-11-20
    Description: Computational and learning theory models propose that behavioral control reflects value that is both cached (computed and stored during previous experience) and inferred (estimated on the fly on the basis of knowledge of the causal structure of the environment). The latter is thought to depend on the orbitofrontal cortex. Yet some accounts propose that the orbitofrontal cortex contributes to behavior by signaling "economic" value, regardless of the associative basis of the information. We found that the orbitofrontal cortex is critical for both value-based behavior and learning when value must be inferred but not when a cached value is sufficient. The orbitofrontal cortex is thus fundamental for accessing model-based representations of the environment to compute value rather than for signaling value per se.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592380/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592380/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jones, Joshua L -- Esber, Guillem R -- McDannald, Michael A -- Gruber, Aaron J -- Hernandez, Alex -- Mirenzi, Aaron -- Schoenbaum, Geoffrey -- F32 DA031517/DA/NIDA NIH HHS/ -- F32-031517/PHS HHS/ -- R01 DA015718/DA/NIDA NIH HHS/ -- R01-DA015718/DA/NIDA NIH HHS/ -- ZIA DA000587-01/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2012 Nov 16;338(6109):953-6. doi: 10.1126/science.1227489.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 21201, USA. josh.jones@nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23162000" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Behavior, Animal ; Conditioning (Psychology) ; Cues ; Frontal Lobe/*physiology ; *Learning ; Male ; Rats ; Rats, Inbred LEC
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 172
    facet.materialart.
    Unknown
    Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-11-01
    Description: Aberrant signaling through the class I phosphatidylinositol 3-kinase (PI3K)-Akt axis is frequent in human cancer. Here, we show that Beclin 1, an essential autophagy and tumor suppressor protein, is a target of the protein kinase Akt. Expression of a Beclin 1 mutant resistant to Akt-mediated phosphorylation increased autophagy, reduced anchorage-independent growth, and inhibited Akt-driven tumorigenesis. Akt-mediated phosphorylation of Beclin 1 enhanced its interactions with 14-3-3 and vimentin intermediate filament proteins, and vimentin depletion increased autophagy and inhibited Akt-driven transformation. Thus, Akt-mediated phosphorylation of Beclin 1 functions in autophagy inhibition, oncogenesis, and the formation of an autophagy-inhibitory Beclin 1/14-3-3/vimentin intermediate filament complex. These findings have broad implications for understanding the role of Akt signaling and intermediate filament proteins in autophagy and cancer.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507442/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507442/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, Richard C -- Wei, Yongjie -- An, Zhenyi -- Zou, Zhongju -- Xiao, Guanghua -- Bhagat, Govind -- White, Michael -- Reichelt, Julia -- Levine, Beth -- K08 CA164047/CA/NCI NIH HHS/ -- P30 CA142543/CA/NCI NIH HHS/ -- R01 CA071443/CA/NCI NIH HHS/ -- R01 CA084254/CA/NCI NIH HHS/ -- R01 CA109618/CA/NCI NIH HHS/ -- R01 CA129451/CA/NCI NIH HHS/ -- R01 CA84254-S1/CA/NCI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2012 Nov 16;338(6109):956-9. doi: 10.1126/science.1225967. Epub 2012 Oct 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23112296" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis Regulatory Proteins/genetics/*metabolism ; *Autophagy ; Cell Line, Tumor ; Cell Transformation, Neoplastic/genetics/*metabolism ; Fibroblasts/metabolism/pathology ; HeLa Cells ; Humans ; Membrane Proteins/genetics/*metabolism ; Mice ; Phosphorylation ; Proto-Oncogene Proteins c-akt/genetics/*metabolism ; RNA, Small Interfering/genetics ; Rats ; Transduction, Genetic ; Vimentin/genetics ; Xenograft Model Antitumor Assays
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 173
    facet.materialart.
    Unknown
    Evolution of shape by multiple regulatory changes to a growth gene (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-03-01
    Description: The genetic changes responsible for morphological differences between species are largely unidentified. Such changes can involve modifications of growth that are relevant to understanding evolution, development, and disease. We identified a gene that induces male-specific wing size and shape differences between Nasonia wasp species. Fine-scale mapping and in situ hybridization reveal that changes in at least three regions (two strictly in noncoding sequence) around the gene unpaired-like (upd-like) cause changes in spatial and temporal expression of upd-like in the developing wing and corresponding changes in wing width. Upd-like shows homology to the Drosophila unpaired gene, a well-studied signaling protein that regulates cell proliferation and differentiation. Our results indicate how multiple changes in the regulation of upd-like are involved in microevolution of morphological and sex-specific differences between species.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520604/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520604/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Loehlin, David W -- Werren, John H -- 5R01 GM070026-04/GM/NIGMS NIH HHS/ -- 5R24 GM084917-04/GM/NIGMS NIH HHS/ -- R01 GM070026/GM/NIGMS NIH HHS/ -- R24 GM084917/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2012 Feb 24;335(6071):943-7. doi: 10.1126/science.1215193.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of Rochester, Rochester, NY 14627, USA. loehlin@wisc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22363002" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; *Biological Evolution ; Cloning, Molecular ; Drosophila/genetics ; Drosophila Proteins/genetics ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Developmental ; Genes, Insect ; Insect Proteins/*genetics/metabolism ; Male ; Molecular Sequence Data ; Morphogenesis/genetics ; Organ Size ; Quantitative Trait Loci ; Sex Characteristics ; Species Specificity ; Transcription Factors/genetics ; Wasps/anatomy & histology/*genetics/*growth & development ; Wings, Animal/*anatomy & histology/*growth & development/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 174
    facet.materialart.
    Unknown
    Comment on "Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition" (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-08-11
    Description: Ray et al. (Reports, 29 July 2011, p. 637) assume that clozapine-N4-oxide (CNO) represents a "biologically inert synthetic ligand" that selectively activates the M4 muscarinic receptor-based DREADD (designer receptor exclusively activated by a designer drug). In contrast, due to the redox cycling of CNO with clozapine and to their cell membrane permeability, CNO is biologically active and its conversion products are capable of undermining DREADD effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Loffler, Stefan -- Korber, Jochen -- Nubbemeyer, Udo -- Fehsel, Karin -- New York, N.Y. -- Science. 2012 Aug 10;337(6095):646; author reply 646. doi: 10.1126/science.1221810.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry and Psychotherapy, Clinic Offenbach, Teaching Hospital of Goethe University, D-63069 Offenbach, Germany. stefloeffler@t-online.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22879486" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Body Temperature Regulation ; Chemoreceptor Cells/*physiology ; Clozapine/*analogs & derivatives ; *Neural Inhibition ; Neurons/*physiology ; *Respiration ; Serotonin/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 175
    facet.materialart.
    Unknown
    Biosecurity. Will flu papers lead to new research oversight? (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-01-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- Malakoff, David -- New York, N.Y. -- Science. 2012 Jan 6;335(6064):20, 22. doi: 10.1126/science.335.6064.20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22223781" target="_blank"〉PubMed〈/a〉
    Keywords: *Access to Information ; Advisory Committees ; Animals ; Biomedical Research ; Bioterrorism/*prevention & control ; Humans ; Influenza A Virus, H5N1 Subtype/genetics/*pathogenicity ; Influenza, Human/transmission ; International Cooperation ; Orthomyxoviridae Infections/*transmission/virology ; *Publishing ; *Security Measures ; United States ; World Health Organization
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 176
    facet.materialart.
    Unknown
    Genomics. China's sequencing powerhouse comes of age (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-02-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Normile, Dennis -- New York, N.Y. -- Science. 2012 Feb 3;335(6068):516-9. doi: 10.1126/science.335.6068.516.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22301291" target="_blank"〉PubMed〈/a〉
    Keywords: *Academies and Institutes ; Animals ; China ; *Computational Biology ; Costs and Cost Analysis ; *Genomics ; Humans ; International Cooperation ; *Sequence Analysis, DNA/economics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 177
    facet.materialart.
    Unknown
    Cancer. Bacteria deliver a genotoxic hit (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-10-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwabe, Robert F -- Wang, Timothy C -- New York, N.Y. -- Science. 2012 Oct 5;338(6103):52-3. doi: 10.1126/science.1229905.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Columbia University, New York, NY 10032, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23042875" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carcinoma/*microbiology ; Colitis/*complications ; Colorectal Neoplasms/*microbiology ; *DNA Damage ; Intestines/*microbiology ; Metagenome/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 178
    facet.materialart.
    Unknown
    Circadian rhythm of redox state regulates excitability in suprachiasmatic nucleus neurons (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-08-04
    Description: Daily rhythms of mammalian physiology, metabolism, and behavior parallel the day-night cycle. They are orchestrated by a central circadian clock in the brain, the suprachiasmatic nucleus (SCN). Transcription of clock genes is sensitive to metabolic changes in reduction and oxidation (redox); however, circadian cycles in protein oxidation have been reported in anucleate cells, where no transcription occurs. We investigated whether the SCN also expresses redox cycles and how such metabolic oscillations might affect neuronal physiology. We detected self-sustained circadian rhythms of SCN redox state that required the molecular clockwork. The redox oscillation could determine the excitability of SCN neurons through nontranscriptional modulation of multiple potassium (K(+)) channels. Thus, dynamic regulation of SCN excitability appears to be closely tied to metabolism that engages the clockwork machinery.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490628/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490628/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, Tongfei A -- Yu, Yanxun V -- Govindaiah, Gubbi -- Ye, Xiaoying -- Artinian, Liana -- Coleman, Todd P -- Sweedler, Jonathan V -- Cox, Charles L -- Gillette, Martha U -- EY014024/EY/NEI NIH HHS/ -- P30 DA018310/DA/NIDA NIH HHS/ -- P30DA018310/DA/NIDA NIH HHS/ -- R01 EY014024/EY/NEI NIH HHS/ -- R01 HL086870/HL/NHLBI NIH HHS/ -- R01 HL092571/HL/NHLBI NIH HHS/ -- R01HL086870/HL/NHLBI NIH HHS/ -- R01HL092571/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2012 Aug 17;337(6096):839-42. doi: 10.1126/science.1222826. Epub 2012 Aug 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22859819" target="_blank"〉PubMed〈/a〉
    Keywords: ARNTL Transcription Factors/genetics ; Animals ; *Circadian Rhythm ; Fluorometry ; Glutathione/metabolism ; Membrane Potentials ; Mice ; Mice, Mutant Strains ; NADP/metabolism ; Neurons/metabolism/*physiology ; Oxidation-Reduction ; Potassium Channels/metabolism ; Rats ; Suprachiasmatic Nucleus/cytology/metabolism/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 179
    facet.materialart.
    Unknown
    Profile: Stephen Friend. The visionary (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-02-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2012 Feb 10;335(6069):651-3. doi: 10.1126/science.335.6069.651.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22323794" target="_blank"〉PubMed〈/a〉
    Keywords: Access to Information ; Animals ; *Computational Biology ; Computer Simulation ; Databases, Factual ; *Drug Discovery ; History, 20th Century ; History, 21st Century ; Humans ; *Information Dissemination ; Software ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 180
    facet.materialart.
    Unknown
    Research funding. The contribution of private industry to agricultural innovation (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-11-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fuglie, Keith -- Heisey, Paul -- King, John -- Pray, Carl E -- Schimmelpfennig, David -- New York, N.Y. -- Science. 2012 Nov 23;338(6110):1031-2. doi: 10.1126/science.1226294.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Economic Research Service, U.S. Department of Agriculture, Washington, DC 20472, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23180847" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture/*economics ; Animals ; *Capital Financing ; *Crops, Agricultural ; *Livestock ; Research/*economics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 181
    facet.materialart.
    Unknown
    Cell biology. Donation spurs a cell observatory--and bigger plans (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-02-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2012 Feb 3;335(6068):514. doi: 10.1126/science.335.6068.514.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22301289" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes/*economics ; Animals ; *Cell Physiological Processes ; Foundations ; *Gene Regulatory Networks ; Humans ; Massachusetts ; *Metabolic Networks and Pathways ; *Models, Biological
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 182
    facet.materialart.
    Unknown
    Developmental biology. Intestinal wound healing requires a Wnt balancing act (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-10-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barrett, Terrence A -- New York, N.Y. -- Science. 2012 Oct 5;338(6103):51-2. doi: 10.1126/science.1229414.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine and Microbiology/Immunology, Division of Gastroenterology, Northwestern University Medical School, Chicago, IL 60611, USA. tbarrett@nmff.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23042874" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Colon/*injuries/*physiology ; Transforming Growth Factor beta/*metabolism ; Wnt Proteins/*physiology ; Wound Healing/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 183
    facet.materialart.
    Unknown
    The transcription factor c-Maf controls touch receptor development and function (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-02-22
    Description: The sense of touch relies on detection of mechanical stimuli by specialized mechanosensory neurons. The scarcity of molecular data has made it difficult to analyze development of mechanoreceptors and to define the basis of their diversity and function. We show that the transcription factor c-Maf/c-MAF is crucial for mechanosensory function in mice and humans. The development and function of several rapidly adapting mechanoreceptor types are disrupted in c-Maf mutant mice. In particular, Pacinian corpuscles, a type of mechanoreceptor specialized to detect high-frequency vibrations, are severely atrophied. In line with this, sensitivity to high-frequency vibration is reduced in humans carrying a dominant mutation in the c-MAF gene. Thus, our work identifies a key transcription factor specifying development and function of mechanoreceptors and their end organs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wende, Hagen -- Lechner, Stefan G -- Cheret, Cyril -- Bourane, Steeve -- Kolanczyk, Maria E -- Pattyn, Alexandre -- Reuter, Katja -- Munier, Francis L -- Carroll, Patrick -- Lewin, Gary R -- Birchmeier, Carmen -- New York, N.Y. -- Science. 2012 Mar 16;335(6074):1373-6. doi: 10.1126/science.1214314. Epub 2012 Feb 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Developmental Biology, Max Delbruck Center (MDC) for Molecular Medicine, Berlin, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22345400" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ganglia, Spinal/cytology/embryology ; Gene Expression Regulation, Developmental ; Humans ; Maf Transcription Factors, Large/genetics/metabolism ; Mechanoreceptors/*cytology/*physiology ; Mice ; Mutation ; Pacinian Corpuscles/cytology/physiology ; Proto-Oncogene Proteins c-maf/genetics/*metabolism ; Proto-Oncogene Proteins c-ret/genetics/metabolism ; Skin/innervation ; *Touch ; Vibration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 184
    facet.materialart.
    Unknown
    Regulated virulence controls the ability of a pathogen to compete with the gut microbiota (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-05-15
    Description: The virulence mechanisms that allow pathogens to colonize the intestine remain unclear. Here, we show that germ-free animals are unable to eradicate Citrobacter rodentium, a model for human infections with attaching and effacing bacteria. Early in infection, virulence genes were expressed and required for pathogen growth in conventionally raised mice but not germ-free mice. Virulence gene expression was down-regulated during the late phase of infection, which led to relocation of the pathogen to the intestinal lumen where it was outcompeted by commensals. The ability of commensals to outcompete C. rodentium was determined, at least in part, by the capacity of the pathogen and commensals to grow on structurally similar carbohydrates. Thus, pathogen colonization is controlled by bacterial virulence and through competition with metabolically related commensals.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439148/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439148/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kamada, Nobuhiko -- Kim, Yun-Gi -- Sham, Ho Pan -- Vallance, Bruce A -- Puente, Jose L -- Martens, Eric C -- Nunez, Gabriel -- DK091191/DK/NIDDK NIH HHS/ -- DK61707/DK/NIDDK NIH HHS/ -- R01 DK061707/DK/NIDDK NIH HHS/ -- R01 DK091191/DK/NIDDK NIH HHS/ -- Canadian Institutes of Health Research/Canada -- New York, N.Y. -- Science. 2012 Jun 8;336(6086):1325-9. doi: 10.1126/science.1222195. Epub 2012 May 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, MI 48109, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22582016" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacterial Load ; Bacterial Proteins/genetics/metabolism ; Bacteroides/*growth & development ; Citrobacter rodentium/genetics/growth & development/immunology/*pathogenicity ; Enterobacteriaceae Infections/immunology/*microbiology ; Escherichia coli/*growth & development ; Feces/microbiology ; Gene Expression Regulation, Bacterial ; Germ-Free Life ; Intestinal Mucosa/*microbiology ; Intestines/*microbiology ; *Metagenome ; Mice ; Mice, Inbred C57BL ; *Microbial Interactions ; Specific Pathogen-Free Organisms ; Virulence Factors/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 185
    facet.materialart.
    Unknown
    Ecology. Fences make good nest sites (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pala, Christopher -- New York, N.Y. -- Science. 2012 Jun 29;336(6089):1628. doi: 10.1126/science.336.6089.1628.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22745391" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Birds/*physiology ; Conservation of Natural Resources ; Ecology/methods ; Ecosystem ; Geography ; Hawaii ; Introduced Species ; *Nesting Behavior ; Predatory Behavior ; Reproduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 186
    facet.materialart.
    Unknown
    Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-12-01
    Description: Chronic infections strain the regenerative capacity of antiviral T lymphocyte populations, leading to failure in long-term immunity. The cellular and molecular events controlling this regenerative capacity, however, are unknown. We found that two distinct states of virus-specific CD8(+) T cells exist in chronically infected mice and humans. Differential expression of the T-box transcription factors T-bet and Eomesodermin (Eomes) facilitated the cooperative maintenance of the pool of antiviral CD8(+) T cells during chronic viral infection. T-bet(hi) cells displayed low intrinsic turnover but proliferated in response to persisting antigen, giving rise to Eomes(hi) terminal progeny. Genetic elimination of either subset resulted in failure to control chronic infection, which suggests that an imbalance in differentiation and renewal could underlie the collapse of immunity in humans with chronic infections.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653769/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653769/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Paley, Michael A -- Kroy, Daniela C -- Odorizzi, Pamela M -- Johnnidis, Jonathan B -- Dolfi, Douglas V -- Barnett, Burton E -- Bikoff, Elizabeth K -- Robertson, Elizabeth J -- Lauer, Georg M -- Reiner, Steven L -- Wherry, E John -- 059312/Wellcome Trust/United Kingdom -- AI061699/AI/NIAID NIH HHS/ -- AI0663445/AI/NIAID NIH HHS/ -- AI076458/AI/NIAID NIH HHS/ -- AI078897/AI/NIAID NIH HHS/ -- AI082630/AI/NIAID NIH HHS/ -- AI083022/AI/NIAID NIH HHS/ -- HHSN266200500030C/AI/NIAID NIH HHS/ -- HHSN266200500030C/PHS HHS/ -- P01 AI078897/AI/NIAID NIH HHS/ -- P30 CA016520/CA/NCI NIH HHS/ -- P30 DK043351/DK/NIDDK NIH HHS/ -- R01 AI042370/AI/NIAID NIH HHS/ -- R01 AI061699/AI/NIAID NIH HHS/ -- R01 AI076458/AI/NIAID NIH HHS/ -- T32 AI007632/AI/NIAID NIH HHS/ -- T32-AI-07324/AI/NIAID NIH HHS/ -- U19 AI082630/AI/NIAID NIH HHS/ -- U19 AI083022/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2012 Nov 30;338(6111):1220-5. doi: 10.1126/science.1229620.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23197535" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; CD8-Positive T-Lymphocytes/*immunology ; Hepatitis B, Chronic/*immunology ; Humans ; Liver/virology ; Lymphocyte Activation ; Mice ; Mice, Knockout ; Stem Cells/immunology ; T-Box Domain Proteins/genetics/*metabolism ; T-Lymphocyte Subsets/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 187
    facet.materialart.
    Unknown
    Sequential signaling crosstalk regulates endomesoderm segregation in sea urchin embryos (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-02-04
    Description: The segregation of embryonic endomesoderm into separate endoderm and mesoderm fates is not well understood in deuterostomes. Using sea urchin embryos, we showed that Notch signaling initiates segregation of the endomesoderm precursor field by inhibiting expression of a key endoderm transcription factor in presumptive mesoderm. The regulatory circuit activated by this transcription factor subsequently maintains transcription of a canonical Wnt (cWnt) ligand only in endoderm precursors. This cWnt ligand reinforces the endoderm state, amplifying the distinction between emerging endoderm and mesoderm. Before gastrulation, Notch-dependent nuclear export of an essential beta-catenin transcriptional coactivator from mesoderm renders it refractory to cWnt signals, insulating it against an endoderm fate. Thus, we report that endomesoderm segregation is a progressive process, requiring a succession of regulatory interactions between cWnt and Notch signaling.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sethi, Aditya J -- Wikramanayake, Radhika M -- Angerer, Robert C -- Range, Ryan C -- Angerer, Lynne M -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2012 Feb 3;335(6068):590-3. doi: 10.1126/science.1212867.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22301319" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blastomeres/cytology/physiology ; Blastula/physiology ; Embryo, Nonmammalian/embryology/*physiology ; *Embryonic Development ; Endoderm/embryology/*physiology ; Gastrulation ; Gene Expression Regulation, Developmental ; Gene Regulatory Networks ; Ligands ; Mesoderm/embryology/physiology ; Receptors, Notch/genetics/*metabolism ; Sea Urchins/*embryology/genetics/physiology ; *Signal Transduction ; TCF Transcription Factors/genetics/metabolism ; Transcription Factors/metabolism ; Wnt Proteins/genetics/*metabolism ; Wnt Signaling Pathway ; beta Catenin/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 188
    facet.materialart.
    Unknown
    The cellular basis of GABA(B)-mediated interhemispheric inhibition (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-03-01
    Description: Interhemispheric inhibition is thought to mediate cortical rivalry between the two hemispheres through callosal input. The long-lasting form of this inhibition is believed to operate via gamma-aminobutyric acid type B (GABA(B)) receptors, but the process is poorly understood at the cellular level. We found that the firing of layer 5 pyramidal neurons in rat somatosensory cortex due to contralateral sensory stimulation was inhibited for hundreds of milliseconds when paired with ipsilateral stimulation. The inhibition acted directly on apical dendrites via layer 1 interneurons but was silent in the absence of pyramidal cell firing, relying on metabotropic inhibition of active dendritic currents recruited during neuronal activity. The results not only reveal the microcircuitry underlying interhemispheric inhibition but also demonstrate the importance of active dendritic properties for cortical output.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Palmer, Lucy M -- Schulz, Jan M -- Murphy, Sean C -- Ledergerber, Debora -- Murayama, Masanori -- Larkum, Matthew E -- New York, N.Y. -- Science. 2012 Feb 24;335(6071):989-93. doi: 10.1126/science.1217276.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Physiologisches Institut, Universitat Bern, Buhlplatz 5, CH-3012 Bern, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22363012" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Calcium/metabolism ; Cerebrum/*physiology ; Corpus Callosum/physiology ; Dendrites/*physiology ; Electric Stimulation ; Hindlimb ; Interneurons/physiology ; *Neural Inhibition ; Patch-Clamp Techniques ; Pyramidal Cells/*physiology ; Rats ; Rats, Wistar ; Receptors, GABA-B/*metabolism ; Somatosensory Cortex/cytology/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 189
    facet.materialart.
    Unknown
    Designing cell-compatible hydrogels for biomedical applications (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-02
    Description: Hydrogels are polymeric materials distinguished by high water content and diverse physical properties. They can be engineered to resemble the extracellular environment of the body's tissues in ways that enable their use in medical implants, biosensors, and drug-delivery devices. Cell-compatible hydrogels are designed by using a strategy of coordinated control over physical properties and bioactivity to influence specific interactions with cellular systems, including spatial and temporal patterns of biochemical and biomechanical cues known to modulate cell behavior. Important new discoveries in stem cell research, cancer biology, and cellular morphogenesis have been realized with model hydrogel systems premised on these designs. Basic and clinical applications for hydrogels in cell therapy, tissue engineering, and biomedical research continue to drive design improvements using performance-based materials engineering paradigms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seliktar, Dror -- New York, N.Y. -- Science. 2012 Jun 1;336(6085):1124-8. doi: 10.1126/science.1214804.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa 32000, Israel. dror@bm.technion.ac.il〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22654050" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biocompatible Materials ; Biomedical Research ; Biomimetic Materials ; Biotechnology ; *Cell Physiological Phenomena ; Cell Transplantation ; Drug Delivery Systems ; Humans ; *Hydrogels/chemical synthesis/chemistry/therapeutic use ; Molecular Structure ; Tissue Engineering ; Translational Medical Research
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 190
    facet.materialart.
    Unknown
    Glucocorticoids can induce PTSD-like memory impairments in mice (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-03-01
    Description: Posttraumatic stress disorder (PTSD) is characterized by a hypermnesia of the trauma and by a memory impairment that decreases the ability to restrict fear to the appropriate context. Infusion of glucocorticoids in the hippocampus after fear conditioning induces PTSD-like memory impairments and an altered pattern of neural activation in the hippocampal-amygdalar circuit. Mice become unable to identify the context as the correct predictor of the threat and show fear responses to a discrete cue not predicting the threat in normal conditions. These data demonstrate PTSD-like memory impairments in rodents and identify a potential pathophysiological mechanism of this condition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaouane, Nadia -- Porte, Yves -- Vallee, Monique -- Brayda-Bruno, Laurent -- Mons, Nicole -- Calandreau, Ludovic -- Marighetto, Aline -- Piazza, Pier Vincenzo -- Desmedt, Aline -- New York, N.Y. -- Science. 2012 Mar 23;335(6075):1510-3. doi: 10.1126/science.1207615. Epub 2012 Feb 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉CNRS UMR 5228, Centre de Neurosciences Integratives et Cognitives, Talence, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22362879" target="_blank"〉PubMed〈/a〉
    Keywords: Amygdala/*physiopathology ; Animals ; Conditioning (Psychology) ; Corticosterone/*administration & dosage/blood/metabolism/pharmacology ; Cues ; Electroshock ; *Fear ; Hippocampus/*physiopathology ; Male ; Memory Disorders/chemically induced/*physiopathology ; Mice ; Mice, Inbred C57BL ; Proto-Oncogene Proteins c-fos/metabolism ; Restraint, Physical ; Stress Disorders, Post-Traumatic/*physiopathology ; Stress, Psychological
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 191
    facet.materialart.
    Unknown
    Climate's role in polar bear past (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Galbreath, Kurt E -- Cook, Joseph A -- Hoberg, Eric P -- New York, N.Y. -- Science. 2012 Jun 8;336(6086):1230. doi: 10.1126/science.336.6086.1230-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22679079" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; *Genome ; *Multilocus Sequence Typing ; Ursidae/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 192
    facet.materialart.
    Unknown
    Removal of shelterin reveals the telomere end-protection problem (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-05-05
    Description: The telomere end-protection problem is defined by the aggregate of DNA damage signaling and repair pathways that require repression at telomeres. To define the end-protection problem, we removed the whole shelterin complex from mouse telomeres through conditional deletion of TRF1 and TRF2 in nonhomologous end-joining (NHEJ) deficient cells. The data reveal two DNA damage response pathways not previously observed upon deletion of individual shelterin proteins. The shelterin-free telomeres are processed by microhomology-mediated alternative-NHEJ when Ku70/80 is absent and are attacked by nucleolytic degradation in the absence of 53BP1. The data establish that the end-protection problem is specified by six pathways [ATM (ataxia telangiectasia mutated) and ATR (ataxia telangiectasia and Rad3 related) signaling, classical-NHEJ, alt-NHEJ, homologous recombination, and resection] and show how shelterin acts with general DNA damage response factors to solve this problem.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477646/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477646/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sfeir, Agnel -- de Lange, Titia -- AG016642/AG/NIA NIH HHS/ -- GM49046/GM/NIGMS NIH HHS/ -- R01 AG016642/AG/NIA NIH HHS/ -- R01 CA076027/CA/NCI NIH HHS/ -- R37 GM049046/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2012 May 4;336(6081):593-7. doi: 10.1126/science.1218498.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22556254" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Nuclear/genetics/metabolism ; Ataxia Telangiectasia Mutated Proteins ; Cell Cycle ; Cell Cycle Proteins/metabolism ; Cells, Cultured ; Chromosomal Proteins, Non-Histone/metabolism ; DNA Breaks, Double-Stranded ; DNA End-Joining Repair ; DNA Ligases/metabolism ; DNA Repair ; DNA-Binding Proteins/genetics/metabolism ; Homologous Recombination ; Mice ; Mice, Knockout ; Poly(ADP-ribose) Polymerases/metabolism ; Protein-Serine-Threonine Kinases/metabolism ; Signal Transduction ; Telomere/*metabolism/ultrastructure ; *Telomere Homeostasis ; Telomere-Binding Proteins/genetics/*metabolism ; Telomeric Repeat Binding Protein 1/genetics/metabolism ; Telomeric Repeat Binding Protein 2/genetics/metabolism ; Tumor Suppressor Proteins/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 193
    facet.materialart.
    Unknown
    Arthropod diversity in a tropical forest (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-12-15
    Description: Most eukaryotic organisms are arthropods. Yet, their diversity in rich terrestrial ecosystems is still unknown. Here we produce tangible estimates of the total species richness of arthropods in a tropical rainforest. Using a comprehensive range of structured protocols, we sampled the phylogenetic breadth of arthropod taxa from the soil to the forest canopy in the San Lorenzo forest, Panama. We collected 6144 arthropod species from 0.48 hectare and extrapolated total species richness to larger areas on the basis of competing models. The whole 6000-hectare forest reserve most likely sustains 25,000 arthropod species. Notably, just 1 hectare of rainforest yields 〉60% of the arthropod biodiversity held in the wider landscape. Models based on plant diversity fitted the accumulated species richness of both herbivore and nonherbivore taxa exceptionally well. This lends credence to global estimates of arthropod biodiversity developed from plant models.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Basset, Yves -- Cizek, Lukas -- Cuenoud, Philippe -- Didham, Raphael K -- Guilhaumon, Francois -- Missa, Olivier -- Novotny, Vojtech -- Odegaard, Frode -- Roslin, Tomas -- Schmidl, Jurgen -- Tishechkin, Alexey K -- Winchester, Neville N -- Roubik, David W -- Aberlenc, Henri-Pierre -- Bail, Johannes -- Barrios, Hector -- Bridle, Jon R -- Castano-Meneses, Gabriela -- Corbara, Bruno -- Curletti, Gianfranco -- Duarte da Rocha, Wesley -- De Bakker, Domir -- Delabie, Jacques H C -- Dejean, Alain -- Fagan, Laura L -- Floren, Andreas -- Kitching, Roger L -- Medianero, Enrique -- Miller, Scott E -- Gama de Oliveira, Evandro -- Orivel, Jerome -- Pollet, Marc -- Rapp, Mathieu -- Ribeiro, Servio P -- Roisin, Yves -- Schmidt, Jesper B -- Sorensen, Line -- Leponce, Maurice -- New York, N.Y. -- Science. 2012 Dec 14;338(6113):1481-4. doi: 10.1126/science.1226727.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Smithsonian Tropical Research Institute, Panama City, Republic of Panama. bassety@si.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23239740" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arthropods/*anatomy & histology/*classification ; *Biodiversity ; Herbivory ; Rain ; Trees ; Tropical Climate
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 194
    facet.materialart.
    Unknown
    Friends in fungi (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-09-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Werner, Gijsbert D A -- Kiers, E Toby -- New York, N.Y. -- Science. 2012 Sep 21;337(6101):1452.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22997304" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Fungi ; Humans ; Mycoses/*microbiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 195
    facet.materialart.
    Unknown
    Ecology. The heartbeat of ecosystems (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Palmer, Margaret A -- Febria, Catherine M -- New York, N.Y. -- Science. 2012 Jun 15;336(6087):1393-4. doi: 10.1126/science.1223250.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Chesapeake Biological Laboratory, University of Maryland Center for Environmental Science, Solomons, MD 20688, USA. mpalmer@sesync.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22700910" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Ecosystem ; Invertebrates/*metabolism ; *Plant Leaves ; *Rivers ; *Water Pollution, Chemical
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 196
    facet.materialart.
    Unknown
    Quantifying the impact of human mobility on malaria (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-10-16
    Description: Human movements contribute to the transmission of malaria on spatial scales that exceed the limits of mosquito dispersal. Identifying the sources and sinks of imported infections due to human travel and locating high-risk sites of parasite importation could greatly improve malaria control programs. Here, we use spatially explicit mobile phone data and malaria prevalence information from Kenya to identify the dynamics of human carriers that drive parasite importation between regions. Our analysis identifies importation routes that contribute to malaria epidemiology on regional spatial scales.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675794/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675794/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wesolowski, Amy -- Eagle, Nathan -- Tatem, Andrew J -- Smith, David L -- Noor, Abdisalan M -- Snow, Robert W -- Buckee, Caroline O -- 079080/Wellcome Trust/United Kingdom -- 092654/Wellcome Trust/United Kingdom -- 095127/Wellcome Trust/United Kingdom -- 1U54GM088558/GM/NIGMS NIH HHS/ -- U19 AI089674/AI/NIAID NIH HHS/ -- U19AI089674/AI/NIAID NIH HHS/ -- U54 GM088558/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2012 Oct 12;338(6104):267-70. doi: 10.1126/science.1223467.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Engineering and Public Policy, Carnegie Mellon University, Pittsburgh, PA 15221, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23066082" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Phones ; Communicable Disease Control ; Culicidae/*parasitology ; Humans ; Kenya/epidemiology ; Malaria, Falciparum/*embryology/prevention & control/*transmission ; *Plasmodium falciparum ; Prevalence ; Travel/*statistics & numerical data
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 197
    facet.materialart.
    Unknown
    Network resets in medial prefrontal cortex mark the onset of behavioral uncertainty (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-10-09
    Description: Regions within the prefrontal cortex are thought to process beliefs about the world, but little is known about the circuit dynamics underlying the formation and modification of these beliefs. Using a task that permits dissociation between the activity encoding an animal's internal state and that encoding aspects of behavior, we found that transient increases in the volatility of activity in the rat medial prefrontal cortex accompany periods when an animal's belief is modified after an environmental change. Activity across the majority of sampled neurons underwent marked, abrupt, and coordinated changes when prior belief was abandoned in favor of exploration of alternative strategies. These dynamics reflect network switches to a state of instability, which diminishes over the period of exploration as new stable representations are formed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Karlsson, Mattias P -- Tervo, Dougal G R -- Karpova, Alla Y -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2012 Oct 5;338(6103):135-9. doi: 10.1126/science.1226518.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23042898" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Behavior, Animal ; Male ; Nerve Net/cytology/*physiology ; Neurons/physiology ; Prefrontal Cortex/cytology/*physiology ; Rats ; Rats, Long-Evans ; Rejection (Psychology) ; Reward ; *Uncertainty
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 198
    facet.materialart.
    Unknown
    Evolution. Splicing in 4D (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-12-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Papasaikas, Panagiotis -- Valcarcel, Juan -- New York, N.Y. -- Science. 2012 Dec 21;338(6114):1547-8. doi: 10.1126/science.1233219.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre de Regulacio Genomica, 08003 Barcelona, Spain.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23258879" target="_blank"〉PubMed〈/a〉
    Keywords: *Alternative Splicing ; Animals ; *Evolution, Molecular ; *Gene Expression Regulation ; Male ; Mammals/*genetics ; Protein Isoforms/*genetics ; *Transcriptome ; Vertebrates/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 199
    facet.materialart.
    Unknown
    Regulating the boundaries of dual-use research (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-23
    Description: A new U.S. policy for dual-use life science research defines what is permissible by scientists and the government. However, further negotiations will be needed as governments realize the consequences of such boundaries for research and society.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frankel, Mark S -- New York, N.Y. -- Science. 2012 Jun 22;336(6088):1523-5. doi: 10.1126/science.1221285.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Program on Scientific Responsibility, Human Rights and Law, American Association for the Advancement of Science, Washington, DC 20005, USA. mfrankel@aaas.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22723408" target="_blank"〉PubMed〈/a〉
    Keywords: Access to Information ; Animals ; Biomedical Research/*legislation & jurisprudence ; Financing, Government ; *Government Regulation ; Humans ; Influenza A Virus, H5N1 Subtype ; Information Dissemination ; International Cooperation ; *Public Policy ; *Publishing ; Research Support as Topic ; Security Measures ; United States ; United States Government Agencies
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 200
    facet.materialart.
    Unknown
    Big brains, little bodies (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-12-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wcislo, William T -- New York, N.Y. -- Science. 2012 Dec 14;338(6113):1419; author reply 1419. doi: 10.1126/science.338.6113.1419-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23239715" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Brain/*anatomy & histology/*physiology ; Humans
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...