ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Publication Date: 2011-08-03
    Description: Bacteria optimize the use of their motility appendages to move efficiently on a wide range of surfaces prior to forming multicellular bacterial biofilms. The “twitching” motility mode employed by many bacterial species for surface exploration uses type-IV pili (TFP) as linear actuators to enable directional crawling. In addition to linear motion, however, motility requires turns and changes of direction. Moreover, the motility mechanism must be adaptable to the continually changing surface conditions encountered during biofilm formation. Here, we develop a novel two-point tracking algorithm to dissect twitching motility in this context. We show that TFP-mediated crawling in Pseudomonas aeruginosa consistently alternates between two distinct actions: a translation of constant velocity and a combined translation-rotation that is approximately 20× faster in instantaneous velocity. Orientational distributions of these actions suggest that the former is due to pulling by multiple TFP, whereas the latter is due to release by single TFP. The release action leads to a fast “slingshot” motion that can turn the cell body efficiently by oversteering. Furthermore, the large velocity of the slingshot motion enables bacteria to move efficiently through environments that contain shear-thinning viscoelastic fluids, such as the extracellular polymeric substances (EPS) that bacteria secrete on surfaces during biofilm formation.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 2
    Publication Date: 2014-11-12
    Description: Targeted resequencing technologies have allowed for efficient and cost-effective detection of genomic variants in specific regions of interest. Although capture sequencing has been primarily used for investigating single nucleotide variants and indels, it has the potential to elucidate a broader spectrum of genetic variation, including copy number variants (CNVs). Various methods exist for detecting CNV in whole-genome and exome sequencing datasets. However, no algorithms have been specifically designed for contiguous target sequencing, despite its increasing importance in clinical and research applications. We have developed cnvCapSeq, a novel method for accurate and sensitive CNV discovery and genotyping in long-range targeted resequencing. cnvCapSeq was benchmarked using a simulated contiguous capture sequencing dataset comprising 21 genomic loci of various lengths. cnvCapSeq was shown to outperform the best existing exome CNV method by a wide margin both in terms of sensitivity (92.0 versus 48.3%) and specificity (99.8 versus 70.5%). We also applied cnvCapSeq to a real capture sequencing cohort comprising a contiguous 358 kb region that contains the Complement Factor H gene cluster. In this dataset, cnvCapSeq identified 41 samples with CNV, including two with duplications, with a genotyping accuracy of 99%, as ascertained by quantitative real-time PCR.
    Keywords: Polymorphism/mutation detection
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 3
    Publication Date: 2010-11-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Licinio, Julio -- Easteal, Simon -- Wong, Ma-Li -- England -- Nature. 2010 Nov 11;468(7321):173. doi: 10.1038/468173e.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21068812" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research ; DNA, Z-Form/*chemistry ; Humans ; New South Wales ; Smallpox/*epidemiology ; Smallpox Vaccine ; Universities ; Vaccinia virus/genetics/pathogenicity
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 4
    Publication Date: 2008-11-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wong, Min-Liang -- England -- Nature. 2008 Nov 27;456(7221):443. doi: 10.1038/456443a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19037293" target="_blank"〉PubMed〈/a〉
    Keywords: *Awards and Prizes ; *Congresses as Topic/history ; History, 20th Century ; Nobel Prize ; PubMed ; *Publishing/history ; *Research/history ; Research Personnel/history
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 5
    Publication Date: 2012-01-10
    Description: The centrosome, a cytoplasmic organelle formed by cylinder-shaped centrioles surrounded by a microtubule-organizing matrix, is a hallmark of animal cells. The centrosome is conserved and essential for the development of all animal species described so far. Here, we show that planarians, and possibly other flatworms, lack centrosomes. In planarians, centrioles are only assembled in terminally differentiating ciliated cells through the acentriolar pathway to trigger the assembly of cilia. We identified a large set of conserved proteins required for centriole assembly in animals and note centrosome protein families that are missing from the planarian genome. Our study uncovers the molecular architecture and evolution of the animal centrosome and emphasizes the plasticity of animal cell biology and development.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347778/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347778/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Azimzadeh, Juliette -- Wong, Mei Lie -- Downhour, Diane Miller -- Sanchez Alvarado, Alejandro -- Marshall, Wallace F -- GM077004/GM/NIGMS NIH HHS/ -- GM57260/GM/NIGMS NIH HHS/ -- R01 GM057260/GM/NIGMS NIH HHS/ -- R01 GM077004/GM/NIGMS NIH HHS/ -- R37 GM057260/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2012 Jan 27;335(6067):461-3. doi: 10.1126/science.1214457. Epub 2012 Jan 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Biophysics, University of California-San Francisco, CA 94143, USA. juliette.azimzadeh@ucsf.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22223737" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Centrioles/metabolism/ultrastructure ; *Centrosome/metabolism/ultrastructure ; Cilia/metabolism/ultrastructure ; Genome, Helminth ; Helminth Proteins/*genetics/metabolism ; Movement ; Phenotype ; Planarians/*genetics/physiology/*ultrastructure ; RNA Interference ; Regeneration ; Selection, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 6
    Publication Date: 2014-06-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wong, Min-Liang -- England -- Nature. 2014 Jun 5;510(7503):35. doi: 10.1038/510035e.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Chung-Hsing University, Taiwan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24899297" target="_blank"〉PubMed〈/a〉
    Keywords: Astronomy/*education/*instrumentation ; *Empirical Research ; *Internationality ; Science/*education ; Telescopes/*utilization
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 7
    Publication Date: 2012-10-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wong, Min-Liang -- England -- Nature. 2012 Oct 25;490(7421):487. doi: 10.1038/490487e.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23099394" target="_blank"〉PubMed〈/a〉
    Keywords: England ; Financing, Organized ; History, 20th Century ; Laboratories/*history ; *Molecular Biology/history ; Research/economics/*organization & administration/*standards
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 8
    Publication Date: 2013-11-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Licinio, Julio -- Wong, Ma-Li -- England -- Nature. 2013 Nov 14;503(7475):198. doi: 10.1038/503198d.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉South Australian Health and Medical Research Institute, and Flinders University, Adelaide, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24226877" target="_blank"〉PubMed〈/a〉
    Keywords: Databases, Factual/economics/*standards/trends ; Government ; PubMed ; Research/economics/*organization & administration ; United States
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 9
    Publication Date: 2014-10-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wong, Min-Liang -- England -- Nature. 2014 Oct 9;514(7521):168. doi: 10.1038/514168e.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Chung-Hsing University, Taiwan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25297426" target="_blank"〉PubMed〈/a〉
    Keywords: History, 20th Century ; Light Signal Transduction ; *Nobel Prize ; *Photosynthesis ; *Physics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 10
    Publication Date: 2016-03-19
    Description: Observations made during the New Horizons flyby provide a detailed snapshot of the current state of Pluto's atmosphere. Whereas the lower atmosphere (at altitudes of less than 200 kilometers) is consistent with ground-based stellar occultations, the upper atmosphere is much colder and more compact than indicated by pre-encounter models. Molecular nitrogen (N2) dominates the atmosphere (at altitudes of less than 1800 kilometers or so), whereas methane (CH4), acetylene (C2H2), ethylene (C2H4), and ethane (C2H6) are abundant minor species and likely feed the production of an extensive haze that encompasses Pluto. The cold upper atmosphere shuts off the anticipated enhanced-Jeans, hydrodynamic-like escape of Pluto's atmosphere to space. It is unclear whether the current state of Pluto's atmosphere is representative of its average state--over seasonal or geologic time scales.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gladstone, G Randall -- Stern, S Alan -- Ennico, Kimberly -- Olkin, Catherine B -- Weaver, Harold A -- Young, Leslie A -- Summers, Michael E -- Strobel, Darrell F -- Hinson, David P -- Kammer, Joshua A -- Parker, Alex H -- Steffl, Andrew J -- Linscott, Ivan R -- Parker, Joel Wm -- Cheng, Andrew F -- Slater, David C -- Versteeg, Maarten H -- Greathouse, Thomas K -- Retherford, Kurt D -- Throop, Henry -- Cunningham, Nathaniel J -- Woods, William W -- Singer, Kelsi N -- Tsang, Constantine C C -- Schindhelm, Eric -- Lisse, Carey M -- Wong, Michael L -- Yung, Yuk L -- Zhu, Xun -- Curdt, Werner -- Lavvas, Panayotis -- Young, Eliot F -- Tyler, G Leonard -- New Horizons Science Team -- New York, N.Y. -- Science. 2016 Mar 18;351(6279):aad8866. doi: 10.1126/science.aad8866.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Southwest Research Institute, San Antonio, TX 78238, USA. University of Texas at San Antonio, San Antonio, TX 78249, USA. rgladstone@swri.edu. ; Southwest Research Institute, Boulder, CO 80302, USA. ; National Aeronautics and Space Administration, Ames Research Center, Space Science Division, Moffett Field, CA 94035, USA. ; The Johns Hopkins University Applied Physics Laboratory, Laurel, MD 20723, USA. ; George Mason University, Fairfax, VA 22030, USA. ; The Johns Hopkins University, Baltimore, MD 21218, USA. ; Search for Extraterrestrial Intelligence Institute, Mountain View, CA 94043, USA. ; Stanford University, Stanford, CA 94305, USA. ; Southwest Research Institute, San Antonio, TX 78238, USA. ; Southwest Research Institute, San Antonio, TX 78238, USA. University of Texas at San Antonio, San Antonio, TX 78249, USA. ; Nebraska Wesleyan University, Lincoln, NE 68504, USA. ; California Institute of Technology, Pasadena, CA 91125, USA. ; Max-Planck-Institut fur Sonnensystemforschung, 37191 Katlenburg-Lindau, Germany. ; Groupe de Spectroscopie Moleculaire et Atmospherique, Universite Reims Champagne-Ardenne, 51687 Reims, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26989258" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...