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  • Humans  (1,574)
  • American Association for the Advancement of Science (AAAS)  (1,574)
  • Annual Reviews
  • 1980-1984  (1,574)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (1,574)
  • Annual Reviews
Years
Year
  • 101
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    Type III hyperlipoproteinemia associated with apolipoprotein E deficiency (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-11
    Description: Subjects with type III hyperlipoproteinemia develop premature atherosclerosis and have hyperlipidemia due to an increase in cholesterol-rich very low density lipoproteins (VLDL) of abnormal electrophoretic mobility. Apolipoprotein E is a major protein constituent of VLDL and appears to be important for the hepatic uptake of triglyceride-rich lipoproteins. A new kindred of patients with type III hyperlipoproteinemia is described in which no plasma apolipoprotein E could be detected, consistent with the concept that type III hyperlipoproteinemia may be due to an absence or striking deficiency of apolipoprotein E.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ghiselli, G -- Schaefer, E J -- Gascon, P -- Breser, H B Jr -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1239-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6795720" target="_blank"〉PubMed〈/a〉
    Keywords: Apolipoproteins/blood/*deficiency ; Apolipoproteins E ; Humans ; Hyperlipoproteinemia Type III/*blood/genetics ; Immunodiffusion ; Lipoproteins, HDL/blood/*deficiency ; Lipoproteins, VLDL/blood/*deficiency ; Pedigree ; Reference Values
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 102
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    Malignant potential of murine stromal cells after transplantation of human tumors into nude mice (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: Human malignant cancer tumors grafted into nude mice produce tumors containing both human cancer cells and the host's stromal cells. After short-term propagation of these tumors in vitro, the murine mesenchymal cells appear transformed and are tumorigenic in nude mice. However, established human cancer cell lines fail to similarly after adjacent murine stromal cells when used to produce tumors in nude mice. These experiments suggest that cancer cells may recruit normal cells to become malignant, qualifying the view of the clonal (unicellular) origin of cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldenberg, D M -- Pavia, R A -- 1R01 CA17198/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):65-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209521" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/pathology ; Animals ; Cell Line ; Cells, Cultured ; Colonic Neoplasms/pathology ; Fibrosarcoma/*etiology ; Humans ; Karyotyping ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Middle Aged ; Neoplasm Transplantation ; Neoplasms, Experimental/*etiology ; Transplantation, Heterologous
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 103
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    Protozoan parasite of humans: surface membrane with externally disposed acid phosphatase (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-22
    Description: Plasma membranes isolated from the protozoan parasite Leishmania donovani were enriched in acid phosphatase (E.C. 3.1.3.2) activity. Cytochemically, the enzyme was distributed uniformly on the surface of intact cells and was localized on the external face of isolated membranes. Physical characteristics and orientation of the membrane-bound enzyme suggest that the organism is adapted for existence in hydrolytic environments.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gottlieb, M -- Dwyer, D M -- AI-16530/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1981 May 22;212(4497):939-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233189" target="_blank"〉PubMed〈/a〉
    Keywords: Acid Phosphatase/*metabolism ; Animals ; Cell Membrane/*enzymology ; Flagella/enzymology ; Humans ; Intracellular Membranes/enzymology ; Leishmania/*enzymology/ultrastructure ; Microscopy, Electron
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 104
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    Radiosensitivity of human cells in vitro (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Furcinitti, P S -- Todd, P -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209518" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Survival/*radiation effects ; Cells, Cultured ; Dose-Response Relationship, Radiation ; HeLa Cells/radiation effects ; Humans
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 105
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    Natural killer cells: their roles in defenses against disease (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-02
    Description: Natural killer cells are a recently discovered subpopulation of lymphoid cells that are present in most normal individuals of a range of mammalian and avian species. Natural killer cells have spontaneous cytolytic activity against a variety of tumor cells and some normal cells, and their reactivity can be rapidly augmented by interferon. They have characteristics distinct from other types of lymphoid cells and are closely associated with large granular lymphocytes, which comprise about 5 percent of blood or splenic leukocytes. There is increasing evidence that natural killer cells, with the ability to mediate natural resistance against tumors in vivo, certain virus and other microbial diseases, and bone marrow transplants, may play an important role in immune surveillance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Herberman, R B -- Ortaldo, J R -- New York, N.Y. -- Science. 1981 Oct 2;214(4516):24-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7025208" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Surface/analysis ; Communicable Diseases/*immunology ; Humans ; *Immunity, Cellular ; *Immunity, Innate ; Killer Cells, Natural/*immunology ; Macrophages/immunology ; Monocytes/immunology ; Neoplasms/*immunology ; Neutrophils/immunology ; T-Lymphocytes/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 106
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    Coronary treatment assessed (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1981 Jul 10;213(4504):195.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244629" target="_blank"〉PubMed〈/a〉
    Keywords: Evaluation Studies as Topic ; Humans ; Myocardial Revascularization/*methods
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 107
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    Genes regulated through chromatin structure (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1981 Nov 13;214(4522):775-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7292010" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Chromatin/*ultrastructure ; Deoxyribonucleases/metabolism ; *Gene Expression Regulation ; Humans ; Nucleic Acid Conformation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 108
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    Data sought on low cholesterol and cancer (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-03-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1981 Mar 27;211(4489):1410-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466398" target="_blank"〉PubMed〈/a〉
    Keywords: Cholesterol/*blood ; Humans ; Neoplasms/*etiology ; Research ; Risk
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 109
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    Affective behavior in patients with localized cortical excisions: role of lesion site and side (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-02
    Description: The perception of emotion in verbal and facial expression, and the spontaneous production of conversational speech were studied in patients with unilateral focal excisions of frontal, temporal, or parieto-occipital cortex. Lesions of the left hemisphere impaired the matching of verbal descriptions to appropriate verbal categories of emotional states, whereas with lesions of the right hemisphere, the matching of different faces displaying similar emotional states was impaired. The effects of lesions of both left and right hemisphere occurred regardless of the locus of the lesion. On the other hand, frontal-lobe lesions had differential effects upon unsolicited talking; lesions of the left frontal lobe virtually abolished this behavior, whereas lesions of the right frontal lobe produced excessive talking. These data suggest that the nature of the behavioral stimulus as well as the locus and side of damage must be considered in the study of the neural basis of affective behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolb, B -- Taylor, L -- New York, N.Y. -- Science. 1981 Oct 2;214(4516):89-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7280683" target="_blank"〉PubMed〈/a〉
    Keywords: Affect/*drug effects ; Behavior/physiology ; Cerebral Cortex/*physiology ; *Facial Expression ; Functional Laterality ; Humans ; Perception/*physiology ; Verbal Behavior/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 110
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    Rational approaches to chemotherapy: antisickling agents (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klotz, I M -- Haney, D N -- King, L C -- New York, N.Y. -- Science. 1981 Aug 14;213(4509):724-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256275" target="_blank"〉PubMed〈/a〉
    Keywords: Anemia, Sickle Cell/*drug therapy ; Aspirin/analogs & derivatives/therapeutic use ; Chemical Phenomena ; Chemistry ; *Hemoglobin, Sickle ; Humans ; Protein Binding/drug effects ; Protein Conformation ; Salicylates/*therapeutic use ; Solubility ; Structure-Activity Relationship
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 111
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    An experiment that had to succeed (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewin, R -- New York, N.Y. -- Science. 1981 May 15;212(4496):767-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6784239" target="_blank"〉PubMed〈/a〉
    Keywords: Antibodies/*immunology ; Antibodies, Monoclonal ; B-Lymphocytes/*immunology ; Biopsy ; Clone Cells/immunology ; Hodgkin Disease/immunology ; Humans ; Hybrid Cells/*immunology ; Plasmacytoma/*immunology ; Research Design
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 112
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    Myasthenia gravis under monoclonal scrutiny (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewin, R -- New York, N.Y. -- Science. 1981 Jan 2;211(4477):38-40, 42.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6160615" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/metabolism ; Antibody Specificity ; *Autoantibodies ; Clone Cells/immunology ; Epitopes ; Humans ; Hybrid Cells/immunology ; Myasthenia Gravis/*immunology ; Receptors, Cholinergic/*immunology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 113
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    Asbestos surface charge heterogeneity and biological effects (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-09-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Light, W G -- New York, N.Y. -- Science. 1981 Sep 25;213(4515):1534.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7280676" target="_blank"〉PubMed〈/a〉
    Keywords: *Asbestos ; Humans ; Occupational Diseases/chemically induced ; Structure-Activity Relationship
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 114
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    An endocrine approach to the control of epidermal growth: serum-free cultivation of human keratinocytes (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-03-27
    Description: Human keratinocytes, derived from the skin of newborns and of adults, were grown in the complete absence of serum, in a hormone-supplemented medium on fibronectin-coated cell culture dishes at low seed density. The cell culture medium consisted of Medium 199 containing epidermal growth factor, triiodothyronine, hydrocortisone, Cohn fraction IV, insulin, transferrin, bovine brain extract, and trace elements. Removal of the brain extract from the hormone supplement had a greater negative impact on proliferation of the keratinocyte cultures than did the removal of epidermal growth factor, hydrocortisone, and triiodothyronine or Cohn fraction IV. The growth of keratinocytes in this hormone-supplemented medium suggests that control of keratinocyte growth depends in large part on endocrine stimulation by other body organs, including the brain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maciag, T -- Nemore, R E -- Weinstein, R -- Gilchrest, B A -- AG 0599/AG/NIA NIH HHS/ -- HO 07374/HO/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1981 Mar 27;211(4489):1452-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6970413" target="_blank"〉PubMed〈/a〉
    Keywords: Brain Chemistry ; Culture Media ; Culture Techniques/*methods ; Epidermal Growth Factor/*pharmacology ; Face ; Fibronectins ; Hormones/*pharmacology ; Humans ; Infant, Newborn ; Male ; Middle Aged ; Mitogens/pharmacology ; Penis ; Peptides/*pharmacology ; Skin/*cytology/drug effects
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 115
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    Sexual differentiation of the central nervous system (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-03-20
    Description: Sexual differentiation of reproductive and behavior patterns is largely effected by hormones produced by the gonads. In many higher vertebrates, an integral part of this process is the induction of permanent and essentially irreversible sex differences in central nervous function, in response to gonadal hormones secreted early in development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉MacLusky, N J -- Naftolin, F -- New York, N.Y. -- Science. 1981 Mar 20;211(4488):1294-302.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6163211" target="_blank"〉PubMed〈/a〉
    Keywords: Androgens/metabolism/physiology ; Animals ; Birds/physiology ; Brain/metabolism ; Central Nervous System/*embryology/physiology ; Estrogens/physiology ; Female ; Humans ; Male ; Mammals/physiology ; Morphogenesis ; Ovary/secretion ; Receptors, Cell Surface/metabolism ; Receptors, Steroid/metabolism ; Sex Characteristics ; Sex Determination Analysis ; *Sex Differentiation ; Testis/secretion ; Time Factors ; alpha-Fetoproteins/physiology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 116
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    FDA sees no radiation risk in VDT screens (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1981 Jun 5;212(4499):1120-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7248044" target="_blank"〉PubMed〈/a〉
    Keywords: *Data Display ; Humans ; Radiation Injuries/*etiology ; Risk ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 117
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    A monosialoganglioside is a monoclonal antibody-defined antigen of colon carcinoma (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: The antigen of a monoclonal antibody that is specific for cells of human carcinoma of the colon is a monosialoganglioside as determined by the direct binding of antibody to thin-layer chromatograms of total lipid extracts of tissues. Binding of antibody to chromatograms is detected by autoradiography after the application of iodine-125-labeled F(ab')2 of rabbit immunoglobulin G antibodies to mouse immunoglobulins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Magnani, J L -- Brockhaus, M -- Smith, D F -- Ginsburg, V -- Blaszczyk, M -- Mitchell, K F -- Steplewski, Z -- Koprowski, H -- CA-10815/CA/NCI NIH HHS/ -- CA-21124/CA/NCI NIH HHS/ -- RR-05540/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):55-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209516" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/*immunology ; Antibodies, Neoplasm/*immunology ; Antibody Specificity ; Antigens, Neoplasm/*immunology/isolation & purification ; Cell Line ; Chromatography, Thin Layer ; Colonic Neoplasms/*immunology ; Gangliosides/*immunology/isolation & purification ; Humans ; Melanoma/immunology ; Neuraminidase/pharmacology
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  • 118
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    Guinea worm disease (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hopkins, D R -- Foege, W H -- New York, N.Y. -- Science. 1981 May 1;212(4494):495.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6451929" target="_blank"〉PubMed〈/a〉
    Keywords: Dracunculiasis/*prevention & control ; Humans ; Water Supply/*standards
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 119
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    T cells scrutinized at Rudesheim meeting (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1981 Nov 20;214(4523):893-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6117944" target="_blank"〉PubMed〈/a〉
    Keywords: Antibody Formation ; Congresses as Topic ; Germany, West ; Humans ; Societies, Scientific ; T-Lymphocytes/*immunology ; Thymus Gland/immunology
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  • 120
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    Brain opiates in mental illness (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1981 Nov 27;214(4524):1013-15.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302574" target="_blank"〉PubMed〈/a〉
    Keywords: Brain/*physiopathology ; Endorphins/*physiology ; Humans ; Mental Disorders/*physiopathology ; Schizophrenia/physiopathology
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  • 121
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    Intrathecal interferon reduces exacerbations of multiple sclerosis (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-27
    Description: Ten patients with multiple sclerosis who were treated with human fibroblast interferon (IFN-B) for 6 months showed a significant reduction in their exacerbation rates compared with their rates before treatment (P 〈 .01). The IFN-B was administered intrathecally by serial lumbar punctures. There was no significant change in the exacerbation rates of ten multiple sclerosis control patients before and during the period of observation. The IFN-B recipients have now been on the study a mean of 1.5 years, the controls, 1.2 years. The clinical condition of five of the IFN-B recipients and one of the control patients has improved, whereas the condition of five of the controls and one of the IFN-B recipients has deteriorated (P 〈 .036). These findings warrant cautious optimism about the efficacy of intrathecal IFN-B in altering the course of multiple sclerosis and support concepts of a viral or dysimmune etiology of the disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jacobs, L -- O'Malley, J -- Freeman, A -- Ekes, R -- CA-18533/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Nov 27;214(4524):1026-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6171035" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Clinical Trials as Topic ; Female ; Fibroblasts ; Follow-Up Studies ; Humans ; Interferons/*therapeutic use ; Male ; Multiple Sclerosis/*drug therapy
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    Cancer incidence in the Love Canal area (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-19
    Description: Data from the New York Cancer Registry show no evidence for higher cancer rates associated with residence near the Love Canal toxic waste burial site in comparison with the entire state outside of New York City. Rates of liver cancer, lymphoma, and leukemia, which were selected for special attention, were not consistently elevated. Among the other cancers studied, a higher rate was noted only for respiratory cancer, but it was not consistent across age groups and appeared to be related to a high rate for the entire city of Niagara Falls. There was no evidence that the lung cancer rate was associated with the toxic wastes buried at the dump site.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Janerich, D T -- Burnett, W S -- Feck, G -- Hoff, M -- Nasca, P -- Polednak, A P -- Greenwald, P -- Vianna, N -- New York, N.Y. -- Science. 1981 Jun 19;212(4501):1404-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233229" target="_blank"〉PubMed〈/a〉
    Keywords: Carcinogens ; Female ; Humans ; Leukemia/epidemiology ; Liver Neoplasms/epidemiology ; Lymphoma/epidemiology ; Male ; Neoplasms/*epidemiology ; New York ; Registries ; Soil Pollutants/*adverse effects
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Evoked potentials (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1981 Jul 17;213(4505):322-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244618" target="_blank"〉PubMed〈/a〉
    Keywords: Brain Diseases/diagnosis ; *Evoked Potentials ; Humans ; Infant ; Nervous System Diseases/diagnosis ; *Neurologic Examination ; Sudden Infant Death
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    Natriuretic hormone linked to hypertension (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1981 Jun 12;212(4500):1255-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6262915" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Humans ; Hypertension/*etiology ; *Natriuresis ; Natriuretic Agents ; Proteins/*physiology ; Rats ; Sodium/metabolism ; Sodium-Potassium-Exchanging ATPase/metabolism
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    Antibodies: getting their genes together (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1981 May 29;212(4498):1015-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6785883" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies/*genetics ; Base Sequence ; *Genes ; Humans ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Light Chains/genetics ; Immunoglobulins/*genetics ; Transcription, Genetic
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Tumor viruses and the kinase connection (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-03-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1981 Mar 20;211(4488):1336-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6259729" target="_blank"〉PubMed〈/a〉
    Keywords: Abelson murine leukemia virus/enzymology ; Alpharetrovirus/enzymology ; Animals ; Avian Sarcoma Viruses/enzymology ; Cell Adhesion ; *Cell Transformation, Viral ; Glycolysis ; Humans ; Oncogene Protein pp60(v-src) ; Oncogenic Viruses/*enzymology ; Phosphoproteins/physiology ; Phosphorylation ; Protein Kinases/*physiology ; Tumor Virus Infections/*enzymology ; Tyrosine/metabolism ; Viral Proteins/*physiology
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    A new wave of antibiotics builds (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1225-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302591" target="_blank"〉PubMed〈/a〉
    Keywords: *Cephalosporins/therapeutic use ; Humans ; Research ; Structure-Activity Relationship ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Is there a gene for depression? (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1981 Dec 18;214(4527):1330-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7313691" target="_blank"〉PubMed〈/a〉
    Keywords: Depression/*genetics ; Genetic Linkage ; HLA Antigens/genetics ; Humans
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    FDA approves hepatitis B vaccine (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H -- New York, N.Y. -- Science. 1981 Dec 4;214(4525):1113.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302582" target="_blank"〉PubMed〈/a〉
    Keywords: Hepatitis B/*prevention & control ; Hepatitis B Surface Antigens/*standards ; Humans ; United States ; United States Food and Drug Administration ; *Vaccines
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    New ways to use metals for arthritis (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1981 Apr 24;212(4493):430-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209540" target="_blank"〉PubMed〈/a〉
    Keywords: *Anti-Inflammatory Agents ; Arthritis, Rheumatoid/*drug therapy ; Humans ; Organometallic Compounds/*therapeutic use ; Osmium/*therapeutic use
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    Immunohistochemical demonstration of a testicular substance related to luteinizing hormone-releasing hormone (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-09-11
    Description: A substance related to luteinizing hormone-releasing hormone was demonstrated, by immunohistochemical procedures, in the cytoplasm of interstitial cells within the rat testes. In many seminiferous tubules, nuclei of spermatogonial cells were also immunopositive. Both cytoplasmic and nuclear fractions of testicular homogenates contain immunoreactive compounds, and this report identifies which cell types contain this substance. The localization of a peptide hormone within the nucleus of a target cell population may indicate its mode of action.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Paull, W K -- Turkelson, C M -- Thomas, C R -- Arimura, A -- HD14761/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1981 Sep 11;213(4513):1263-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7022653" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibody Specificity ; Cell Nucleus/metabolism ; Cytoplasm/metabolism ; Gonadotropin-Releasing Hormone/immunology/*metabolism ; Humans ; Immunologic Techniques ; Leydig Cells/metabolism ; Male ; Rats ; Spermatogonia/metabolism ; Testis/*metabolism
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    Brain tumors in children and occupational exposure of parents (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-10
    Description: Ninety-two cases of brain tumor in children less than 10 years old were compared with 92 matched controls for parental occupational history. Cases were more likely than controls to show material occupations involving chemical exposure, paternal occupations involving solvents, and employment of father in the aircraft industry. These three factors were not affected by adjustment for the potential confounding variables examined in this study.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peters, F M -- Preston-Martin, S -- Yu, M C -- P01CA17054/CA/NCI NIH HHS/ -- R01CA20571/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Jul 10;213(4504):235-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244631" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollutants/*adverse effects ; Air Pollutants, Occupational/*adverse effects ; Brain Neoplasms/*chemically induced ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Male ; *Maternal-Fetal Exchange ; Pregnancy ; Respiration ; Risk ; Skin Absorption ; Solvents
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    Human lupus inclusions and interferon (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-14
    Description: Raji cells, a human B lymphoblastoid cell line of Burkitt lymphoma origin, formed lupus inclusions when grown in a medium conditioned by the growth of Raji cells whose DNA thymidine residues had been unifilarly (single-strandedly) substituted with bromodeoxyuridine. Ultracentrifugation of this medium in excess of that required to remove Epstein-Barr virus and all other known mammalian viruses did not prevent the formation of the inclusions, and treatment of the conditioned medium with pronase destroyed the activity. These results demonstrate the presence of a protein that is secreted from bromodeoxyuridine-substituted Raji cells and is capable of inducing nonbromodeoxyuridine-substituted cells to form lupus inclusions. Interferon (100 units per milliliter) was found in the conditioned medium. Inclusions also formed in Raji cells grown in fresh medium supplemented with human leukocyte or fibroblast interferon (100 units per milliliter).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rich, S A -- New York, N.Y. -- Science. 1981 Aug 14;213(4509):772-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6166984" target="_blank"〉PubMed〈/a〉
    Keywords: Bromodeoxyuridine/*metabolism ; Burkitt Lymphoma ; Cell Line ; Culture Media ; Cytoplasmic Granules/ultrastructure ; DNA Replication ; Humans ; Interferons/*biosynthesis ; Lupus Erythematosus, Systemic/*pathology
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    Tinkering with life (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rensberger, Boyce -- New York, N.Y. -- Science. 1981 Nov;2(9):44-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11662884" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Technology ; *DNA, Recombinant ; Economics ; *Genetic Therapy ; Government Regulation ; Humans ; *Industry ; Information Dissemination ; Information Services ; *Research Personnel ; Risk ; Risk Assessment ; Social Control, Formal ; Universities
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    Rod-cone interaction in the distal human retina (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-15
    Description: During the rod-isolated phase of dark adaption, b-wave implicit time of the human cone electroretinogram increased exponentially with a time constant corresponding to that for the regeneration of rhodopsin. In the presence of different photopically equated short-wave backgrounds, cone b-wave implicit time varied inversely with the scotopic brightness of the background. Taking into account the origin of the b wave, these measurements support the idea of a rod effect on cone function in the distal human retina.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sandberg, M A -- Berson, E L -- Effron, M -- EY00169/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1981 May 15;212(4496):829-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7221568" target="_blank"〉PubMed〈/a〉
    Keywords: Electroretinography ; Humans ; Photoreceptor Cells/*physiology ; Retina/*physiology ; *Vision, Ocular
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Determination of nucleotide sequences in DNA (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sanger, F -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1205-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302589" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Bacteriophages/genetics ; *Base Sequence ; Cloning, Molecular ; DNA/*genetics ; DNA, Mitochondrial/genetics ; DNA, Single-Stranded/genetics ; DNA-Directed DNA Polymerase ; Humans ; Protein Biosynthesis ; Templates, Genetic
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    Cognitive interaction after staged callosal section: evidence for transfer of semantic activation (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-17
    Description: Sensory and cognitive functions were assessed in a right-handed male before and after partial and complete callosal commissurotomy. After the initial posterior section was made, there was no evidence of interhemispheric sensory transfer, although the left hemisphere did have access to stimulus-related semantic and episodic information from the right hemisphere. After the callosum was completely sectioned, this exchange was no longer observed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sidtis, J J -- Volpe, B T -- Holtzman, J D -- Wilson, D H -- Gazzaniga, M S -- 2 R01 NS15053-02/NS/NINDS NIH HHS/ -- RR001-02/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 17;212(4492):344-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6782673" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Cognition/*physiology ; Cognition Disorders/*physiopathology ; Corpus Callosum/*physiology/surgery ; Epilepsy, Tonic-Clonic/surgery ; Humans ; Language Disorders/*physiopathology ; Male ; Methods ; Perception/physiology ; Perceptual Disorders/*physiopathology ; Postoperative Complications/physiopathology ; Sensation/*physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Low-fat diet poses little or no cancer risk (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1981 May 29;212(4498):1006-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233194" target="_blank"〉PubMed〈/a〉
    Keywords: *Dietary Fats ; Humans ; Neoplasms/*etiology ; Risk
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    FDA plans action on sodium in foods (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1981 Jun 19;212(4501):1373.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233225" target="_blank"〉PubMed〈/a〉
    Keywords: *Food Handling ; Humans ; *Sodium ; United States ; *United States Food and Drug Administration
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    OSHA shifts direction on health standards (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-06-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1981 Jun 26;212(4502):1482-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233234" target="_blank"〉PubMed〈/a〉
    Keywords: *Federal Government ; *Government Agencies ; *Government Regulation ; *Health Policy ; Humans ; Occupational Diseases/*prevention & control ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Serum lipoproteins modulate oxygenated sterol insertion into human red cell membranes (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-06-12
    Description: The insertion of oxygenated sterol compounds into human red blood cell membranes as well as the consequent transformation of the red cells to an echinocyte shape and the expansion of the membranes are impeded by the presence of serum lipoproteins in the incubation medium. All density classes of human serum lipoproteins bind oxygenated sterol compounds, and lipoproteins can act as acceptors of oxygenated sterols previously inserted into red cells. Since oxygenated sterols have been reported to be atherogenic, the modulating and possibly protective effects of serum lipoproteins on oxygenated sterol-induced derangement of cell membrane structure and function may provide a useful model for further study.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Streuli, R A -- Chung, J -- Scanu, A M -- Yachnin, S -- 1 P30 AM26678-01/AM/NIADDK NIH HHS/ -- HL 18577/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1981 Jun 12;212(4500):1294-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233221" target="_blank"〉PubMed〈/a〉
    Keywords: Cholesterol/*blood ; Erythrocyte Membrane/*physiology ; Erythrocytes/*physiology ; Humans ; Hydroxycholesterols/*blood ; Lipoproteins/*blood ; Lipoproteins, HDL/blood ; Lipoproteins, LDL/blood ; Lipoproteins, VLDL/blood
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  • 142
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    Cancer institute passes first test in senate (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1981 Jun 5;212(4499):1122.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233205" target="_blank"〉PubMed〈/a〉
    Keywords: Government Agencies ; Humans ; National Institutes of Health (U.S.) ; *Neoplasms ; Politics ; *Research Support as Topic ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 143
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    Compensation for victims of vaccines (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-02-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1981 Feb 27;211(4485):906-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466364" target="_blank"〉PubMed〈/a〉
    Keywords: *Compensation and Redress ; Costs and Cost Analysis ; Disclosure ; Drug Industry/economics/*standards ; *Federal Government ; Humans ; Insurance ; *Jurisprudence ; Mandatory Programs ; Risk ; Risk Assessment ; United States ; Vaccines/*adverse effects ; Voluntary Programs
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 144
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    Cancer institute's drug program reproved (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1981 Nov 20;214(4523):887-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302567" target="_blank"〉PubMed〈/a〉
    Keywords: Disclosure ; Drug Evaluation/*standards ; Federal Government ; *Government Regulation ; Humans ; *National Institutes of Health (U.S.) ; Neoplasms/*drug therapy ; Politics ; Risk Assessment ; *Therapeutic Human Experimentation ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
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  • 145
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    Institute, keratotomists don't see eye to eye (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1981 Jul 24;213(4506):423-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244640" target="_blank"〉PubMed〈/a〉
    Keywords: Evaluation Studies as Topic ; Humans ; Myopia/*surgery ; National Institutes of Health (U.S.) ; Research Support as Topic ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 146
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    Hatch batters NCI with straus case (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1981 Jun 19;212(4501):1366.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7015513" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; *Federal Government ; *Government Regulation ; History, 20th Century ; Humans ; *National Institutes of Health (U.S.) ; Neoplasms ; Politics ; *Research Support as Topic ; United States
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  • 147
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    Amniocentesis: be prepared (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1981 Jun 12;212(4500):1253.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233217" target="_blank"〉PubMed〈/a〉
    Keywords: Abortion, Induced ; *Amniocentesis ; Congenital Abnormalities/diagnosis ; Federal Government ; Female ; Humans ; Legislation, Medical ; Pregnancy ; United States
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  • 148
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    Laetrile brush fire is out, scientists hope (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1981 May 15;212(4496):758-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7221562" target="_blank"〉PubMed〈/a〉
    Keywords: Amygdalin/*therapeutic use ; *Federal Government ; Humans ; Neoplasms/*drug therapy ; Orthomolecular Therapy
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 149
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    Falciparum malaria-infected erythrocytes specifically bind to cultured human endothelial cells (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-31
    Description: Erythrocytes infected with the late stages of the human malarial parasite Plasmodium falciparum became attached to a subpopulation of cultured human endothelial cells by knoblike protrusions on the surface of the infected erythrocytes. Infected erythrocytes did not bind to cultured fibroblasts; uninfected erythrocytes did not bind to either endothelial cells or fibroblasts. The results suggest a specific receptor-ligand interaction between endothelial cells and a component, components, in the knobs of the infected erythrocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Udeinya, I J -- Schmidt, J A -- Aikawa, M -- Miller, L H -- Green, I -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):555-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7017935" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aotus trivirgatus ; Cells, Cultured ; Endothelium/microbiology ; Erythrocytes/*microbiology/ultrastructure ; Female ; Humans ; Microscopy, Electron ; Plasmodium falciparum/*pathogenicity ; Pregnancy ; Umbilical Veins
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  • 150
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    Women scientists and engineers: trends in participation (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-18
    Description: Women have made tremendous strides in educational attainment in science and engineering over the past decade, increasing their proportion of doctorate awards in these fields from 7 percent in 1965 to 23 percent in 1980. But they still have higher unemployment rates and lower salaries than men in all fields of science and engineering, at all degree levels, and at all levels of experience; and the disparities between men and women widen with higher degree levels and with years of experience. Graduate enrollments indicate continuing increases over at least the next several years in degree awards to women, but their access to equal employment and advancement opportunities is not assured.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vetter, B M -- New York, N.Y. -- Science. 1981 Dec 18;214(4527):1313-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7313688" target="_blank"〉PubMed〈/a〉
    Keywords: Education, Graduate ; Employment ; Engineering ; Female ; Humans ; Salaries and Fringe Benefits ; *Science ; *Women
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  • 151
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    The framing of decisions and the psychology of choice (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-30
    Description: The psychological principles that govern the perception of decision problems and the evaluation of probabilities and outcomes produce predictable shifts of preference when the same problem is framed in different ways. Reversals of preference are demonstrated in choices regarding monetary outcomes, both hypothetical and real, and in questions pertaining to the loss of human lives. The effects of frames on preferences are compared to the effects of perspectives on perceptual appearance. The dependence of preferences on the formulation of decision problems is a significant concern for the theory of rational choice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tversky, A -- Kahneman, D -- New York, N.Y. -- Science. 1981 Jan 30;211(4481):453-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7455683" target="_blank"〉PubMed〈/a〉
    Keywords: *Choice Behavior ; *Decision Making ; Humans ; Probability
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  • 152
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    Yellow rain and the cloud of chemical war (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, N -- New York, N.Y. -- Science. 1981 Nov 27;214(4524):1008-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302573" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Warfare ; Cambodia ; Humans ; Laos
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  • 153
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    NIH committee sheds darkness on UCSD case (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, Nicholas -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):27.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11643634" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; *DNA, Recombinant ; Federal Government ; Government ; Government Regulation ; Humans ; *National Institutes of Health (U.S.) ; *Public Policy ; *Research Personnel ; Scientific Misconduct ; Social Control, Formal ; Universities
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  • 154
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    Gene therapy pioneer draws Mikadoesque rap (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, N -- New York, N.Y. -- Science. 1981 Jun 12;212(4500):1253.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6940246" target="_blank"〉PubMed〈/a〉
    Keywords: DNA, Recombinant/*therapeutic use ; Ethics Committees, Research ; Federal Government ; *Genetic Engineering ; *Government Regulation ; Humans ; *Legislation, Medical ; National Institutes of Health (U.S.) ; United States
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  • 155
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    A diversion of the quest for truth (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-03-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, N -- New York, N.Y. -- Science. 1981 Mar 6;211(4486):1022-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466374" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Aotus trivirgatus ; *Cebidae ; *Cell Line ; *Ethics ; HeLa Cells ; Hodgkin Disease/*pathology ; Humans ; Karyotyping ; Research/*standards
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  • 156
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    Gene therapy caught in more entanglements (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, N -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):24-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6259731" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; *DNA, Recombinant ; *Ethics Committees, Research ; *Ethics, Medical ; Federal Government ; Female ; *Genetic Engineering/history ; Genetic Vectors ; Globins/genetics ; Government Regulation ; History, 20th Century ; Humans ; Informed Consent ; Israel ; Plasmids ; Thalassemia/*therapy ; United States
    Print ISSN: 0036-8075
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  • 157
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    Meprobamate reduces accuracy of physiological detection of deception (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: Normal male subjects attempted to deceive an experimenter recording electrodermal, respiratory, an cardiovascular activity. Those who had ingested a placebo or nothing were detected with statistically significant frequency on the basis of their phasic electrodermal responses, which clearly distinguished them from truthful suspects. That was not the case with deceptive subjects who had ingested 400 milligrams of meprobamate, nor did the examiner detect which subjects had received the drug.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Waid, W M -- Orne, E C -- Cook, M R -- Orne, M T -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):71-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209522" target="_blank"〉PubMed〈/a〉
    Keywords: Blood Pressure/drug effects ; Double-Blind Method ; Galvanic Skin Response/drug effects ; Humans ; *Lie Detection ; Male ; Meprobamate/*pharmacology ; Overlearning ; Respiration/drug effects ; Stress, Psychological/physiology
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  • 158
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    The complete index to man (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, N -- New York, N.Y. -- Science. 1981 Jan 2;211(4477):33-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7444446" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; DNA/*genetics ; Electrophoresis, Polyacrylamide Gel ; Humans ; Isoelectric Point ; Molecular Weight ; Proteins/analysis/*genetics
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  • 159
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    Associative Learning in Aplysia: evidence for conditioned fear in an invertebrate (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-30
    Description: Aversive classical conditioning of Aplysia californica, a gastropod mollusk suited for neurobiological study, produces a learned reaction to the chemosensory conditioned stimulus that is expressed as a marked facilitation of four defensive responses: two graded reflexes (head and siphon withdrawal), an all-or-none fixed act (inking), and a complex fixed action pattern (escape locomotion). In addition, the conditioned stimulus produces a concomitant depression of at least one appetitive response, feeding. These extensive and selective actions of the conditioned stimulus in Aplysia resemble the actions of conditioned fear stimuli in higher mammals and suggest that the functional equivalent of fear occurs in invertebrates and thus may be an adaptive mechanism that is widespread in the animal kingdom.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walters, E T -- Carew, T J -- Kandel, E R -- 5K02MH0081/MH/NIMH NIH HHS/ -- 5K05MH18558/MH/NIMH NIH HHS/ -- 5T32MH1574/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1981 Jan 30;211(4481):504-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7192881" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aplysia/*physiology ; Association Learning/*physiology ; Avoidance Learning/physiology ; Behavior, Animal/physiology ; Conditioning (Psychology)/physiology ; Defense Mechanisms ; Fear/*physiology ; Humans ; Learning/*physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 160
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    Cigarette smoking in the 1970's: the impact of the antismoking campaign on consumption (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-02-13
    Description: Per capita cigarette consumption has declined annually since 1973. This downturn represents a new nonsmoking ethos, which is also reflected in the legislative successes of the nonsmokers' rights movement. Time series regression analysis of cigarette demand suggests that, in the absence of the antismoking campaign, consumption would have exceeded its 1978 level by more than a third.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Warner, K E -- HS 03634/HS/AHRQ HHS/ -- New York, N.Y. -- Science. 1981 Feb 13;211(4483):729-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7455711" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Public Health ; Public Opinion ; *Smoking
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 161
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    Effects of vasopressin on human memory functions (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-02-06
    Description: Arginine vasopressin and a number of its synthetic analogs augment memory functions in experimental animals. One of these analogs, 1-desamino-8-D-arginine vasopressin (DDAVP), influences human learning and memory. Cognitively unimpaired, as well as cognitively impaired adults, treated with DDAVP for a period of several days, learn information more effectively, as measured by the completeness, organization, and consistency (reliability) of recall. DDAVP also appears to reverse partially the retrograde amnesia that follows electroconvulsive treatment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weingartner, H -- Gold, P -- Ballenger, J C -- Smallberg, S A -- Summers, R -- Rubinow, D R -- Post, R M -- Goodwin, F K -- New York, N.Y. -- Science. 1981 Feb 6;211(4482):601-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7455701" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Arginine Vasopressin/*pharmacology ; Cognition/drug effects ; Deamino Arginine Vasopressin/pharmacology ; Depression/physiopathology ; Female ; Humans ; Learning/*drug effects ; Male ; Memory/*drug effects ; Middle Aged
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  • 162
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    Tumor cell killing by phorbol ester--differentiated human leukemia cells (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-07
    Description: The tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate causes differentiation of cells of the human leukemia cell line HL60 to nondividing macrophage-like cells. These differentiated cells are cytotoxic for tumor cells (including parent, untreated HL60 cells) in vitro. Agents that induce this desirable differentiation to nondividing, antitumor effector cells may be useful in the experimental treatment of leukemia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weinberg, J B -- 27070-02/PHS HHS/ -- New York, N.Y. -- Science. 1981 Aug 7;213(4508):655-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7196085" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation/drug effects ; Cell Line ; *Cytotoxicity, Immunologic ; Humans ; Immunity, Cellular ; Leukemia, Experimental/immunology/*pathology ; Macrophages/cytology/*immunology ; Phorbols/*pharmacology ; Tetradecanoylphorbol Acetate/*pharmacology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 163
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    Mutation caused by human phagocytes (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-01
    Description: Histidine-requiring mutants of Salmonella typhimurium TA100 were incubated with human peripheral blood leukocytes. More of these bacteria reverted to histidine independence than controls not incubated with cells. Phagocyte-rich suspensions were mutagenic, while heat-killed cells, lymphocytes, or mixed blood leukocytes of a patient with chronic granulomatous disease were not. Production of reactive oxygen metabolites could explain the capacity of phagocytes to induce mutation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weitzman, S A -- Stossel, T P -- CA 09321/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 May 1;212(4494):546-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6259738" target="_blank"〉PubMed〈/a〉
    Keywords: Granulomatous Disease, Chronic/physiopathology ; Humans ; Leukocytes/physiology ; Mutagenicity Tests ; *Mutation ; Oxygen/*adverse effects ; Peroxides/adverse effects ; Phagocytes/*physiology ; Salmonella typhimurium/genetics ; Superoxides/adverse effects
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 164
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    The hormonal control of sexual development (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-03-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilson, J D -- George, F W -- Griffin, J E -- AM03892/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Mar 20;211(4488):1278-84.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7010602" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-Mullerian Hormone ; Estradiol/metabolism/*physiology ; Female ; *Glycoproteins ; Gonadotropins/physiology ; *Growth Inhibitors ; Humans ; Male ; Morphogenesis ; Mullerian Ducts ; Ovary/embryology ; Rabbits ; Receptors, Androgen/metabolism ; *Sex Differentiation ; Testicular Hormones/*physiology ; Testis/embryology/secretion ; Testosterone/metabolism/*physiology ; Time Factors ; Urogenital System/embryology ; Wolffian Ducts
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  • 165
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    Stress-induced analgesia in humans: endogenous opioids and naloxone-reversible depression of pain reflexes (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-08
    Description: The cumulative effects of a repetitive stress induced by anticipation of pain (noxious foot shock) were studied on the threshold of a nociceptive flexion reflex of the lower limb. The threshold of the nociceptive reflex progressively increased with the repetition of the stress. This effect was reversed by naloxone, which even produced hyperalgesia, since a rapid and significant decrease in this threshold, below the initial values, was noted. Tha data provide evidence for involvement of endogenous opioids in the phenomenon of stress-induced analgesia in normal man.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Willer, J C -- Dehen, H -- Cambier, J -- New York, N.Y. -- Science. 1981 May 8;212(4495):689-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6261330" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Female ; Humans ; Male ; Naloxone/pharmacology ; Pain/*physiopathology ; Receptors, Opioid/*physiology ; Reflex/drug effects ; Stress, Psychological/*physiopathology
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  • 166
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    Fermentation in the rumen and human large intestine (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-09-25
    Description: Fermentation of food by the microbial community of the rumen is essential for the maintenance and growth of ruminants. The microbial ecosystem and its interaction with the host are described, along with recent attempts to manipulate the composition and activity of the microbial community by adding antibiotics and other chemicals to ruminant diets. A similar microbial community and fermentation occur in the large intestine or cecum of most nonruminant animals including the large intestine of humans. The microbial ecosystems of the rumen and human large intestine are compared.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wolin, M J -- New York, N.Y. -- Science. 1981 Sep 25;213(4515):1463-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7280665" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbohydrate Metabolism ; Cattle ; Fatty Acids/metabolism ; Fermentation ; Humans ; Intestine, Large/microbiology/*physiology ; Methane/metabolism ; Rumen/microbiology/*physiology ; Water-Electrolyte Balance
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  • 167
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    Three distinct genes in human DNA related to the transforming genes of mammalian sarcoma retroviruses (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-10
    Description: Southern blot hybridization was used to identify human and other vertebrate DNA sequences that were homologous to cloned DNA fragments containing the oncogenic nucleic acid sequences of three different type C mammalian retroviruses (simian sarcoma virus, the Snyder-Theilen strain of feline sarcoma virus, and the Harvey strain of murine sarcoma virus). Each onc gene counterpart has a single genetic locus, which probably contains non-onc intervening sequences. The human DNA sequences may represent genes important to cell growth or cell differentiation, or both. Their identification and isolation may allow elucidation of their role in these processes and in neoplasias.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wong-Staal, F -- Dalla-Favera, R -- Franchini, G -- Gelmann, E P -- Gallo, R C -- New York, N.Y. -- Science. 1981 Jul 10;213(4504):226-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6264598" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; *Cell Transformation, Viral ; *Cloning, Molecular ; DNA/*genetics ; DNA, Viral/*genetics ; *Genes ; Humans ; Nucleic Acid Hybridization ; Retroviridae/*genetics ; Sarcoma Virus, Woolly Monkey/genetics ; Sarcoma Viruses, Murine/genetics ; Species Specificity
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  • 168
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    Mesenchymal cells from the human embryonic palate are highly responsive to epidermal growth factor (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-31
    Description: An established line of mesenchymal cells from the human embryonic palate is highly sensitive to the stimulatory effect of epidermal growth factor on growth, labeled thymidine incorporation, and ornithine decarboxylase activity. The results suggest that epidermal growth factor may play a key role in development of various human embryonic and fetal tissues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yoneda, T -- Pratt, R M -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):563-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7017936" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Division/drug effects ; Cell Line ; DNA Replication/drug effects ; Embryo, Mammalian ; Epidermal Growth Factor/*pharmacology ; Female ; Humans ; Insulin/pharmacology ; Kinetics ; Organ Specificity ; Ornithine Decarboxylase/metabolism ; Palate/drug effects/*physiology ; Peptides/*pharmacology ; Pregnancy
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 169
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    Abortion and the limitations of science (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zack, B G -- New York, N.Y. -- Science. 1981 Jul 17;213(4505):291.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244615" target="_blank"〉PubMed〈/a〉
    Keywords: *Abortion, Spontaneous ; *Beginning of Human Life ; *Embryo, Mammalian ; Female ; Humans ; *Jurisprudence ; *Life ; *Personhood ; Pregnancy ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 170
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    Electroencephalographic tolerance and abstinence phenomena during repeated alcohol ingestion by nonalcoholics (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-05
    Description: Certain measures of the auditory average evoked response are sensitive to alcohol and provide evidence for abstinence and tolerance during and after 10 days of alcohol consumption by nonalcoholics. Electroencephalographic techniques provide a single sensitive measure for the study of the etiology of tolerance and abstinence with particular reference to a new area of investigation with nonaddicted humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zilm, D H -- Kaplan, H L -- Capell, H -- New York, N.Y. -- Science. 1981 Jun 5;212(4499):1175-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233213" target="_blank"〉PubMed〈/a〉
    Keywords: Acoustic Stimulation ; *Alcohol Drinking ; Alcoholism/*physiopathology ; Ethanol/pharmacology ; Evoked Potentials/drug effects ; Eye Movements/drug effects ; Heart Rate/drug effects ; Humans ; Male ; Memory/drug effects ; Posture/drug effects ; *Substance Withdrawal Syndrome
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  • 171
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    Induced hearing deficit generates experimental paranoia (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-26
    Description: The development of paranoid reactions was investigated in normal people experiencing a temporary loss of hearing. In a social setting, subjects made partially deaf by hypnotic suggestion, but kept unaware of the source of their deafness, became more paranoid as indicated on a variety of assessment measures. The results support a hypothesizes cognitive-social mechanism for the clinically observed relationship between paranoia and deafness in the elderly.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zimbardo, P G -- Andersen, S M -- Kabat, L G -- New York, N.Y. -- Science. 1981 Jun 26;212(4502):1529-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233242" target="_blank"〉PubMed〈/a〉
    Keywords: Hearing Loss/*psychology ; Hearing Loss, Functional/*psychology ; Humans ; Hypnosis ; Male ; Paranoid Disorders/*etiology ; Personality Tests
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 172
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    Reexamination of acoustic evidence in the Kennedy assassination. Committee on Ballistic Acoustics, National Research Council (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-08
    Description: Sounds recorded in Dallas at the time of the assassination of John F. Kennedy were analyzed by two research groups, whose reports formed the basis for the opinion that two gunmen fired at President Kennedy. These reports and the acoustic evidence have been studied by the Committee on Ballistic Acoustics, and further acoustic analyses, including sound spectrograms, have been performed. The committee finds that the acoustic data do not support a conclusion that a second gunman was involved in the assassination.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1982 Oct 8;218(4568):127-33.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6750789" target="_blank"〉PubMed〈/a〉
    Keywords: Acoustics ; *Famous Persons ; *Forensic Medicine ; History, 20th Century ; Humans ; Male ; Texas ; *Wounds, Gunshot
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  • 173
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    Mycotoxin weapons (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1982 Aug 27;217(4562):776-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7100923" target="_blank"〉PubMed〈/a〉
    Keywords: Asia, Southeastern ; *Biological Warfare ; Humans ; *Mycotoxins
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 174
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    Chromatic valence curves: alternative interpretation derived by the direct matching method (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-03-19
    Description: The amount of red chromatic valence of the red-green opponent colors channel of the human visual system has been reported to be greatly reduced in short wavelengths when the hue-matching method is used to measure red valence instead of the more typical cancellation method. Receptive fields with a silent surround were postulated to explain the reduction, and it was emphasized that the reduced valence curve represented the true chromatic valence curve of the visual system. In the present studies the previous results are interpreted to be a direct consequence of the method and the particular matching stimuli used. It is shown that the reduction can be explained by the existing color-matching data without appealing to the silent surround hypothesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ayama, M -- Ikeda, M -- New York, N.Y. -- Science. 1982 Mar 19;215(4539):1538-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063866" target="_blank"〉PubMed〈/a〉
    Keywords: Color Perception/*physiology ; Humans ; Vision, Ocular/*physiology
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  • 175
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    Gene transfer between eukaryotes (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Benveniste, R E -- Todaro, G J -- New York, N.Y. -- Science. 1982 Sep 24;217(4566):1202.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7112123" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Physiological Phenomena ; Eukaryotic Cells/*physiology ; Humans ; *Recombination, Genetic ; Retroviridae/genetics
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 176
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    Mice regrow the tips of their foretoes (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-20
    Description: Mice will replace the tip of a foretoe when it is amputated distal to the last interphalangeal joint. Amputation of the digit more proximal to the joint does not result in regrowth of the foretoe. Though this growth shares certain similarities with the epimorphic regeneration of amphibian limbs, the two processes are not the same. The regrowth reported here in mice is probably similar to the scattered clinical reports of fingertips regeneration in children, and presents a model system with which to explore the controls of wound healing and tissue reconstruction in mammals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Borgens, R B -- CA 20920/CA/NCI NIH HHS/ -- NS 18456/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 20;217(4561):747-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7100922" target="_blank"〉PubMed〈/a〉
    Keywords: Amputation ; Animals ; Child ; Humans ; Mice ; Mice, Inbred C3H ; *Regeneration ; Toe Joint ; Toes/anatomy & histology/*physiology ; Wound Healing
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  • 177
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    Nonsmokers and cigarette smoke: a modified perception of risk (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bock, F G -- New York, N.Y. -- Science. 1982 Jan 8;215(4529):197.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7053573" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Risk ; *Smoking ; *Tobacco Smoke Pollution
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  • 178
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    Researcher denied future U.S. funds (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broad, William J -- New York, N.Y. -- Science. 1982 Jun 4;216(4550):1081.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11643749" target="_blank"〉PubMed〈/a〉
    Keywords: *Federal Government ; *Financial Support ; *Financing, Government ; *Fraud ; *Government ; Government Regulation ; *Human Experimentation ; Humans ; Neoplasms ; Pharmaceutical Preparations ; Public Policy ; *Research Personnel ; *Scientific Misconduct ; Social Control, Formal ; Social Responsibility ; United States Dept. of Health and Human Services
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  • 179
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    Publisher settles suit, says clone book is a fake (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-04-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broad, William J -- New York, N.Y. -- Science. 1982 Apr 23;216(4544):391.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11643742" target="_blank"〉PubMed〈/a〉
    Keywords: *Cloning, Organism ; *Fraud ; History, 20th Century ; Humans ; Jurisprudence ; Literature
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  • 180
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    Radioactivity in the Urals (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1982 Jul 16;217(4556):198, 200.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089554" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; *Radioactive Fallout ; *Radioactive Pollutants ; *Rural Population ; Ussr
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  • 181
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    T-lymphocyte immunology and hominoid evolution (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cartmill, M -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1145.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6983135" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Humans ; Primates/*genetics ; T-Lymphocytes/*immunology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 182
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    Topological structure in visual perception (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-11-12
    Description: Three experiments on tachistoscopic perception of visual stimuli demonstrate that the visual system is sensitive to global topological properties. The results indicate that extraction of global topological properties is a basic factor in perceptual organization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, L -- New York, N.Y. -- Science. 1982 Nov 12;218(4573):699-700.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7134969" target="_blank"〉PubMed〈/a〉
    Keywords: *Form Perception ; Humans ; *Visual Perception
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 183
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    Phosphoglucomutase: evidence for a new locus expressed in human milk (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-05-07
    Description: Electrophoretic study of phosphoglucomutase (PGM) in human milk revealed different patterns that can be explained by the existence of a locus distinct from the common PGM1, PGM2, and PGM3. One hundred and forty samples were tested and the results showed four different alleles of PGM4 whose frequencies were under Hardy-Weinberg equilibrium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cantu, J M -- Ibarra, B -- New York, N.Y. -- Science. 1982 May 7;216(4546):639-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6461922" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Erythrocytes/enzymology ; Female ; Gene Expression Regulation ; Humans ; Isoenzymes/genetics ; Milk, Human/*enzymology ; Phenotype ; Phosphoglucomutase/*genetics
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 184
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    OSHA policy on carcinogens (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cowan, M D -- New York, N.Y. -- Science. 1982 Sep 3;217(4563):884.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7112101" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Carcinogens ; Humans ; Occupational Diseases/chemically induced ; United States ; *United States Occupational Safety and Health Administration
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 185
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    Autoantibodies to nucleosomal proteins: antibodies to HMG-17 in autoimmune diseases (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-03-05
    Description: The relative amounts of autoantibodies against defined nucleosomal proteins present in serums from patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and mixed connective tissue disease (MCTD) have been examined by an enzyme-linked immunoassay. Autoantibodies to nucleosomal proteins were detected in 45 percent of the patients with SLE, 18 percent of the MCTD patients, and none of the RA patients. The results suggest that, in SLE, antibodies are formed against a subset of nucleosomes which contain protein HMG-17.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bustin, M -- Reisch, J -- Einck, L -- Klippel, J H -- New York, N.Y. -- Science. 1982 Mar 5;215(4537):1245-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6460317" target="_blank"〉PubMed〈/a〉
    Keywords: Arthritis, Rheumatoid/immunology ; Autoimmune Diseases/*immunology ; Chromosomal Proteins, Non-Histone/*immunology ; High Mobility Group Proteins ; Humans ; Lupus Erythematosus, Systemic/immunology ; Mixed Connective Tissue Disease/immunology ; Nucleosomes/*immunology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 186
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    Theory and observation in cultural transmission (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-10-01
    Description: Cultural phenomena may show considerable stability over time and space. Transmission mechanisms responsible for their maintenance are worthy of theoretical and empirical inquiry; they are complex and each possible pathway has different effects on evolutionary stability of traits, as can be shown theoretically. A survey designed to evaluate the importance of some components of cultural transmission on a variety of traits showed that religion and politics are mostly determined in the family, a mode of transmission which guarantees high evolutionary stability and maintenance of high variation between and within groups.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cavalli-Sforza, L L -- Feldman, M W -- Chen, K H -- Dornbusch, S M -- 10452/PHS HHS/ -- 20467/PHS HHS/ -- 20816/PHS HHS/ -- New York, N.Y. -- Science. 1982 Oct 1;218(4567):19-27.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123211" target="_blank"〉PubMed〈/a〉
    Keywords: Attitude ; Child ; Cultural Characteristics ; *Culture ; Family ; Female ; Humans ; *Interpersonal Relations ; Male ; Marriage ; Models, Psychological ; *Parent-Child Relations
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 187
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    Development of mouse embryos in vitro: preimplantation to the limb bud stage (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-01
    Description: Mouse embryos were grown successfully in vitro from the blastocyst stage to the limb bud stage. Mouse blastocysts grown in vitro for 10 days showed blood circulation in the yilk sac, forelimb buds, and the primordia of liver, pancreas, and lungs. These characteristics are indicative of a developmental stage equivalent to one-half of the total gestation period in utero. Improvements in culture conditions from days 7 to 9 have made it feasible to culture mouse blastocysts beyond the early somite stage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, L T -- Hsu, Y C -- AM 19535/AM/NIADDK NIH HHS/ -- AM 28550/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 1;218(4567):66-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123220" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blastocyst/*physiology ; Cell Differentiation ; Culture Media ; Culture Techniques ; Embryo, Mammalian/*physiology ; Female ; Fetal Blood ; Humans ; Mice ; Pregnancy ; Yolk Sac/physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 188
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    A new subtype of human T-cell leukemia virus (HTLV-II) associated with a T-cell variant of hairy cell leukemia (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-11-05
    Description: Human T-cell leukemia virus (HTLV) is a human type-C RNA tumor virus (retrovirus) previously identified in and isolated from several patients with T-cell leukemias or lymphomas. The known virus isolates from the United States and Japan are closely related and are found in adults with an acute malignancy of mature T cells. A related retrovirus has been found in a patient (Mo) with a somewhat different disease (a T-cell variant of relatively benign hairy cell leukemia). Serum from Mo contains antibodies to the major internal core protein (p24) of HTLV. A T-cell line established from the spleen of Mo expresses HTLV antigens. However, HTLV from Mo is significantly different from all previous HTLV isolates in immunological cross-reactivity tests of p24. The usual prototype HTLV isolate is represented as HTLV-I, and the HTLV from Mo is represented as HTLV-II. Individual members of each subgroup may then be identified by subscript initials of the patient [for example, HTLV-I(CR), HTLV-I(MB), and HTLV-II(Mo)].〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kalyanaraman, V S -- Sarngadharan, M G -- Robert-Guroff, M -- Miyoshi, I -- Golde, D -- Gallo, R C -- New York, N.Y. -- Science. 1982 Nov 5;218(4572):571-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6981847" target="_blank"〉PubMed〈/a〉
    Keywords: Antibodies, Viral/analysis ; Humans ; Leukemia, Hairy Cell/*microbiology ; Retroviridae/immunology/*isolation & purification ; T-Lymphocytes/*immunology/microbiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 189
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    Monoclonal antibody to acetylcholine receptor: cell line established from thymus of patient with Myasthenia gravis (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-02-19
    Description: A human B cell line producing a monoclonal antibody to an antigenic determinant of acetylcholine receptors was established by cloning B cells that had been transformed in vitro by Epstein-Barr virus. The B cells were obtained from the thymus of a patient with myasthenia gravis. The antibody produced by the cell line precipitated acetylcholine receptors from denervated and innervated rat muscle and from human muscle, but did not show detectable response to the acetylcholine receptors from the electric organs of Narke japonica. The monoclonal antibody showed identical binding patterns in innervated and denervated rat muscles. Passive transfer of the monoclonal antibody into rats induced moderate muscle weakness and electromyographic changes characteristic of myasthenia gravis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kamo, I -- Furukawa, S -- Tada, A -- Mano, Y -- Iwasaki, Y -- Furuse, T -- Ito, N -- Hayashi, K -- Satoyoshi, E -- New York, N.Y. -- Science. 1982 Feb 19;215(4535):995-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6297000" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibodies, Monoclonal ; B-Lymphocytes/immunology ; *Cell Line ; Cell Transformation, Viral ; Herpesvirus 4, Human ; Humans ; Muscles/immunology/innervation ; Myasthenia Gravis/immunology ; Rats ; Receptors, Cholinergic/*immunology
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  • 190
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    Human immunoglobulin heavy chain genes map to a region of translocations in malignant B lymphocytes (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-04-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kirsch, I R -- Morton, C C -- Nakahara, K -- Leder, P -- New York, N.Y. -- Science. 1982 Apr 16;216(4543):301-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6801764" target="_blank"〉PubMed〈/a〉
    Keywords: B-Lymphocytes/*physiology ; Chromosome Mapping ; Genes ; Humans ; Immunoglobulin Heavy Chains/*genetics ; Leukemia/*genetics ; Recombination, Genetic ; Translocation, Genetic
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  • 191
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    Fetal hemoglobin genes turned on in adults (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1982 Dec 24;218(4579):1295-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6183747" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Anemia, Sickle Cell/therapy ; Azacitidine/therapeutic use ; Fetal Hemoglobin/biosynthesis/*genetics ; Hemoglobin, Sickle/biosynthesis ; Humans ; Male ; Thalassemia/therapy
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  • 192
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    Heart study produces a surprise result (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1982 Oct 1;218(4567):31-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123213" target="_blank"〉PubMed〈/a〉
    Keywords: Diuretics/*adverse effects ; Heart Diseases/*drug therapy ; Humans ; National Institutes of Health (U.S.) ; Risk ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 193
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    On the origin of introns (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewin, R -- New York, N.Y. -- Science. 1982 Sep 3;217(4563):921-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7112105" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Base Sequence ; *Genes ; Humans
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 194
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    Heterogeneity in epidermal basal keratinocytes: morphological and functional correlations (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-03-05
    Description: Two structurally distinct populations of basal keratinocytes, nonserrated and serrated, were observed in cynomolgus monkey and human palm epidermis. Anatomical location, fine structural features, and kinetic properties suggest that nonserrated cells represent a stem cell population and that serrated cells help anchor the epidermis to the dermis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lavker, R M -- Sun, T T -- AM 25140/AM/NIADDK NIH HHS/ -- EY 00125/EY/NEI NIH HHS/ -- EY 02472/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1982 Mar 5;215(4537):1239-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7058342" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division ; Cell Nucleus/metabolism ; Epidermis/*cytology ; Hand ; Humans ; Macaca fascicularis
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  • 195
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    Rabies treatment (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lele, R D -- New York, N.Y. -- Science. 1982 Oct 8;218(4568):110.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123224" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dogs ; Humans ; Medicine, Ayurvedic ; Plant Extracts/*therapeutic use ; *Plants, Medicinal ; Rabies/*prevention & control
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 196
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    Spectral character of sunlight modulates photosynthesis of previtamin D3 and its photoisomers in human skin (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-05-28
    Description: The photosynthesis of previtamin D3 from 7-dehydrocholesterol in human skin was determined after exposure to narrow-band radiation or simulated solar radiation. The optimum wavelengths for the production of previtamin D3 were determined to be between 295 and 300 nanometers. When human skin was exposed to 295-nanometer radiation, up to 65 percent of the original 7-dehydrocholesterol content was converted to previtamin D3. In comparison, when adjacent skin was exposed to simulated solar radiation, the maximum formation of previtamin D3 was about 20 percent. Major differences in the formation of lumisterol3, and tachysterol3 from previtamin D3 were also observed. It is concluded that the spectral character of natural sunlight has a profound effect on the photochemistry of 7-dehydrocholesterol in human skin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉MacLaughlin, J A -- Anderson, R R -- Holick, M F -- AM 27334/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 May 28;216(4549):1001-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6281884" target="_blank"〉PubMed〈/a〉
    Keywords: Cholecalciferol/*biosynthesis/metabolism ; Dehydrocholesterols/radiation effects ; Ergosterol/metabolism ; Humans ; In Vitro Techniques ; Isomerism ; Photochemistry ; Skin/*metabolism ; Spectrum Analysis ; Structure-Activity Relationship ; Ultraviolet Rays
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  • 197
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    How did humans evolve big brains? (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-05-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewin, R -- New York, N.Y. -- Science. 1982 May 21;216(4548):840-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079741" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Brain/*anatomy & histology ; Energy Metabolism ; Humans ; Primates/*anatomy & histology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 198
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    Natural antibodies to human retrovirus HTLV in a cluster of Japanese patients with adult T cell leukemia (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-02-19
    Description: Human T cell lymphoma leukemia virus (HTLV) is a human retrovirus (RNA tumor virus) that was originally isolated from a few patients with leukemias or lymphomas involving mature T lymphocytes. Here we report that the serum of Japanese patients with adult T cell leukemia, but not the serum of tested normal donors, contains high titers of antibodies to HTLV. These observations, together with data from Japan showing that adult T cell leukemia is endemic in southwest Japan, suggest that HTLV is involved in a subtype of human T cell malignancy, including Japanese adult T cell leukemia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robert-Guroff, M -- Nakao, Y -- Notake, K -- Ito, Y -- Sliski, A -- Gallo, R C -- New York, N.Y. -- Science. 1982 Feb 19;215(4535):975-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6760397" target="_blank"〉PubMed〈/a〉
    Keywords: Antibodies, Viral/*analysis ; Antibody Specificity ; Fluorescent Antibody Technique ; Humans ; Japan ; Leukemia/*immunology ; Radioimmunoassay ; Retroviridae/*immunology ; *T-Lymphocytes
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 199
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    Identification of the constant chromosome regions involved in human hematologic malignant disease (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-05-14
    Description: Specific consistent chromosome translocations are regularly observed in certain human leukemias and lymphomas. For the myeloid leukemias, the constant recombinants are: the long arm of 9 to chromosome 22 in chronic myeloid leukemia, the long arm of 21 to chromosome 8 in acute myeloblastic leukemia, and the long arm of 17 to chromosome 15 in acute promyelocytic leukemia. Three related translocations are seen in Burkitt lymphoma and B cell acute lymphocytic leukemia; in each one, chromosome 8 is involved with chromosome 2, 14, or 22. Analysis of a complex translocation affecting chromosomes 8 and 14 indicates that the translocation of chromosome 8 to chromosome 14 is the critical constant rearrangement. The analysis of the DNA at the translocation sites of these chromosomes, rather than the reciprocal of each translocation, appears to be the most productive focus for initial study. The various immunoglobulin loci are located in chromosomes 2, 14, and 22, the chromosomes regularly involved in translocations in Burkitt lymphoma and B cell acute lymphocytic leukemia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rowley, J D -- CA 16910/CA/NCI NIH HHS/ -- CA 19266/CA/NCI NIH HHS/ -- CA 25568/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 May 14;216(4547):749-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079737" target="_blank"〉PubMed〈/a〉
    Keywords: *Chromosome Aberrations ; Chromosomes, Human, 13-15 ; Chromosomes, Human, 16-18 ; Chromosomes, Human, 21-22 and Y ; Chromosomes, Human, 6-12 and X ; Genes ; Humans ; Immunoglobulins/*genetics ; Leukemia/*genetics ; Lymphoma/*genetics ; Translocation, Genetic
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  • 200
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    Sugar and dental caries: a review of human studies (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-30
    Description: Studies of special population groups, epidemiological surveys, controlled longitudinal studies of humans, and longitudinal studies on the effect of sugar substitutes indicate that frequent or high intake of sugary foods predisposes to dental decay. The relation is not always clear-cut, and most studies have important methodological problems and limitations. Longitudinal measurements of caries increments combined with multiple dietary histories are needed to clarity the association between caries and eating habits. The relative cariogenicity of specific foods can be assessed by a combination of in vitro tests, human in vivo tests, and experimental caries in animals. Human diets, however, vary in food items eaten and the frequency and sequence of eating, and these factors can affect the cariogenicity of a food. Therefore, reported correlations must be interpreted with caution.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Newbrun, E -- New York, N.Y. -- Science. 1982 Jul 30;217(4558):418-23.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7046052" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Cariogenic Agents ; Child ; Child, Preschool ; Dental Caries/epidemiology/*etiology ; *Diet, Cariogenic ; Food Habits ; Food Preferences ; Humans ; Longitudinal Studies ; Sucrose/adverse effects/metabolism ; Sweetening Agents/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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