Publication Date:
1981-05-01
Description:
Histidine-requiring mutants of Salmonella typhimurium TA100 were incubated with human peripheral blood leukocytes. More of these bacteria reverted to histidine independence than controls not incubated with cells. Phagocyte-rich suspensions were mutagenic, while heat-killed cells, lymphocytes, or mixed blood leukocytes of a patient with chronic granulomatous disease were not. Production of reactive oxygen metabolites could explain the capacity of phagocytes to induce mutation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weitzman, S A -- Stossel, T P -- CA 09321/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 May 1;212(4494):546-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6259738" target="_blank"〉PubMed〈/a〉
Keywords:
Granulomatous Disease, Chronic/physiopathology
;
Humans
;
Leukocytes/physiology
;
Mutagenicity Tests
;
*Mutation
;
Oxygen/*adverse effects
;
Peroxides/adverse effects
;
Phagocytes/*physiology
;
Salmonella typhimurium/genetics
;
Superoxides/adverse effects
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
