Publication Date:
1981-06-12
Description:
The insertion of oxygenated sterol compounds into human red blood cell membranes as well as the consequent transformation of the red cells to an echinocyte shape and the expansion of the membranes are impeded by the presence of serum lipoproteins in the incubation medium. All density classes of human serum lipoproteins bind oxygenated sterol compounds, and lipoproteins can act as acceptors of oxygenated sterols previously inserted into red cells. Since oxygenated sterols have been reported to be atherogenic, the modulating and possibly protective effects of serum lipoproteins on oxygenated sterol-induced derangement of cell membrane structure and function may provide a useful model for further study.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Streuli, R A -- Chung, J -- Scanu, A M -- Yachnin, S -- 1 P30 AM26678-01/AM/NIADDK NIH HHS/ -- HL 18577/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1981 Jun 12;212(4500):1294-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233221" target="_blank"〉PubMed〈/a〉
Keywords:
Cholesterol/*blood
;
Erythrocyte Membrane/*physiology
;
Erythrocytes/*physiology
;
Humans
;
Hydroxycholesterols/*blood
;
Lipoproteins/*blood
;
Lipoproteins, HDL/blood
;
Lipoproteins, LDL/blood
;
Lipoproteins, VLDL/blood
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
