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  • Chemistry  (63,133)
  • FLUID MECHANICS AND HEAT TRANSFER  (2,603)
  • 1980-1984  (35,205)
  • 1975-1979  (30,531)
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  • 1
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    Picosecond chemical and biological events (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-13
    Description: Picosecond spectroscopy is a relatively new field of science that utilizes ultrashort laser pulses to monitor events taking place in the 10(-12) second regime. The continuing development of picosecond spectroscopy has made possible the detection and measurement of the primary events in many physical and tiological processes. This article describes a currently used picosecond spectroscopy system that is capable of reliably recording picosecond events. Two areas of picosecond research are discussed; one concerns the interaction of electrons in fluids, and the second the primary events in vision.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rentzepis, P M -- New York, N.Y. -- Science. 1978 Oct 13;202(4364):174-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694523" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Electrons ; *Kinetics ; Lasers ; Protons ; *Retinal Pigments ; *Rhodopsin ; Spectrum Analysis/*methods ; Temperature ; *Vision, Ocular
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Benzo(a)pyrene-7,8-dihydrodiol 9,10-oxide adenosine and deoxyadenosine adducts: structure and stereochemistry (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: The structure and absolute stereoconfigurations of four adenosine adducts with (+/-)-7 alpha,8 beta-dihydroxy-9 beta, 10 beta-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (BPDE) and their deoxyadenosine analogs have been determined. They result from both cis and trans addition of the N6 amino group of ademine to the 10 position of both enantiomers of BDPE. This was determined from studies of the nuclear magnetic resonance spectra, mass spectra, and circular dichroism spectra, as well as from their pKa values and chemical reactivities.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jeffrey, A M -- Grzeskowiak, K -- Weinstein, I B -- Nakanishi, K -- Roller, P -- Harvey, R G -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1309-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/316186" target="_blank"〉PubMed〈/a〉
    Keywords: *Benzopyrenes ; Chemical Phenomena ; Chemistry ; Circular Dichroism ; Dna ; *Deoxyadenosines/analogs & derivatives ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Molecular Conformation ; Mutation ; Stereoisomerism
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  • 3
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    Rational approaches to chemotherapy: antisickling agents (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klotz, I M -- Haney, D N -- King, L C -- New York, N.Y. -- Science. 1981 Aug 14;213(4509):724-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256275" target="_blank"〉PubMed〈/a〉
    Keywords: Anemia, Sickle Cell/*drug therapy ; Aspirin/analogs & derivatives/therapeutic use ; Chemical Phenomena ; Chemistry ; *Hemoglobin, Sickle ; Humans ; Protein Binding/drug effects ; Protein Conformation ; Salicylates/*therapeutic use ; Solubility ; Structure-Activity Relationship
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  • 4
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    Alpha-substituted gamma-butyrolactones: new class of anticonvulsant drugs (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-10
    Description: Alkyl-Substituted gamma-butyrolactones were synthesized and tested for their convulsant and anticonvulsant actions in mice and guinea pigs. The alpha-substituted compounds, alpha, alpha-dimethyl-, and alpha-ethyl-alpha-methyl-gamma-butyrolactone were anticonvulsant compounds with a spectrum of activity similar to that of ethosuximide. In contrast, beta-substituted compounds were convulsant agents similar to picrotoxinin. The alpha-substituted-gama-butyrolactones represent a new class of anticonvulsant drug with experimental and clinical potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klunk, W E -- McKeon, A -- Covey, D F -- Ferrendelli, J A -- GM-07200/GM/NIGMS NIH HHS/ -- GM-24483/GM/NIGMS NIH HHS/ -- NS-14834/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):1040-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6810462" target="_blank"〉PubMed〈/a〉
    Keywords: *4-Butyrolactone/analogs & derivatives/*therapeutic use/toxicity ; Animals ; *Anticonvulsants ; Chemical Phenomena ; Chemistry ; Convulsants ; Drug Evaluation, Preclinical ; Electroencephalography ; Epilepsy, Absence/drug therapy ; Ethosuximide/pharmacology ; *Furans/*therapeutic use ; Guinea Pigs ; Mice ; Structure-Activity Relationship ; Trimethadione/pharmacology
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  • 5
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    Phase transition and crystal structure of the 37 degrees C form of cholesterol (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-06
    Description: Crystalline cholesterol undergoes a phase transition a few degrees below human body temperature. The high-temperature form has an unusually complex structure with 16 independent molecules. In the transition two molecules change side chain conformation, four reorient about their long axes, and ten remain unchanged. The transition mechanism implies relatively nonspecific intermolecular interactions, qualitatively consistent with the behavior of cholesterol in biomembranes. The transition preserves a remarkably closely obeyed pseudosymmetry present in the structure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hsu, L Y -- Nordman, C E -- GM15259/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 May 6;220(4597):604-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836303" target="_blank"〉PubMed〈/a〉
    Keywords: Body Temperature ; Chemical Phenomena ; Chemistry ; *Cholesterol ; Crystallization ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Conformation
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Cytochrome a3 structure in carbon monoxide-bound cytochrome oxidase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-07-20
    Description: The iron-carbon monoxide stretching mode and the iron-carbon-oxygen bending mode in carbon monoxide-bound cytochrome oxidase have been assigned at 520 and 578 cm-1, respectively. The frequencies, widths, and intensities of these modes show that the Fe-C-O grouping in carbon monoxide-cytochrome a3 is linear but tilted from the normal to the heme plane; that the iron-histidine bond in both five- and six-coordinate cytochrome a3 is strained; and that the carbon monoxide and the proximal histidine each have characteristic, well-defined orientations in all molecules. These data can account for the binding affinities of carbon monoxide and dioxygen under physiological conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Argade, P V -- Ching, Y C -- Rousseau, D L -- New York, N.Y. -- Science. 1984 Jul 20;225(4659):329-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6330890" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbon Monoxide/metabolism ; Cattle ; Chemical Phenomena ; Chemistry ; Electron Transport Complex IV/*metabolism ; Myoglobin/metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Spectrum Analysis, Raman
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  • 7
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    Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-06
    Description: Arachidonic acid plays a central role in a biological control system where such oxygenated derivatives as prostaglandins, thromboxanes, and leukotrienes are mediators. The leukotrienes are formed by transformation of arachidonic acid into an unstable epoxide intermediate, leukotriene A4, which can be converted enzymatically by hydration to leukotriene B4, and by addition of glutathione to leukotriene C4. This last compound is metabolized to leukotrienes D4 and E4 by successive elimination of a gamma-glutamyl residue and glycine. Slow-reacting substance of anaphylaxis consists of leukotrienes C4, D4, and E4. The cysteinyl-containing leukotrienes are potent bronchoconstrictors, increase vascular permeability in postcapillary venules, and stimulate mucus secretion. Leukotriene B4 causes adhesion and chemotactic movement of leukocytes and stimulates aggregation, enzyme release, and generation of superoxide in neutrophils. Leukotrienes C4, D4, and E4, which are released from the lung tissue of asthmatic subjects exposed to specific allergens, seem to play a pathophysiological role in immediate hypersensitivity reactions. These leukotrienes, as well as leukotriene B4, have pro-inflammatory effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Samuelsson, B -- New York, N.Y. -- Science. 1983 May 6;220(4597):568-75.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301011" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachidonic Acids/metabolism/pharmacology/physiology ; Bronchi/drug effects ; Cats ; Chemical Phenomena ; Chemistry ; Cricetinae ; Guinea Pigs ; Haplorhini ; Humans ; Hypersensitivity, Immediate/*physiopathology ; Inflammation/*physiopathology ; Leukocytes/drug effects/metabolism ; Leukotriene B4/pharmacology/*physiology ; Mice ; Microcirculation/drug effects ; Rabbits ; Rats ; SRS-A/*physiology
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  • 8
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    Amphiphilic secondary structure: design of peptide hormones (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-01-20
    Description: Peptide synthesis can be used for elucidating the roles of secondary structures in the specificity of hormones, antigens, and toxins. Intermediate sized peptides with these activities assume amphiphilic secondary structures in the presence of membranes. When models are designed to optimize the amphiphilicity of the secondary structure, stronger interactions can be observed with the synthetic peptides than with the naturally occurring analogs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, E T -- Kezdy, F J -- HL-18577/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 20;223(4633):249-55.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322295" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Apolipoprotein A-I ; Apolipoproteins ; Binding Sites ; Calcitonin ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone ; Endorphins ; Glucagon ; Growth Hormone-Releasing Hormone ; *Hormones/pharmacology ; Lipoproteins, HDL ; Melitten ; Models, Structural ; *Peptides/chemical synthesis/metabolism/pharmacology ; Protein Conformation ; Structure-Activity Relationship ; beta-Endorphin
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  • 9
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    Fourier transform mass spectrometry (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-19
    Description: Fourier transform mass spectrometry will play an important role in the future because of its unique combination of high mass resolution, high upper mass limit, and multichannel advantage. These features have already found application in gas chromatography-mass spectrometry, multiphoton ionization, laser desorption, and secondary ion mass spectrometry. However, its most notable feature is the ability to store ions. This characteristic, when combined with the others, will allow expeditious study of the interaction of gas-phase ions with both photons (photodissociation) and neutral molecules, and the convenient application of this fundamental information for chemical analysis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gross, M L -- Rempel, D L -- 2-8423576/PHS HHS/ -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):261-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6385250" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Fourier Analysis ; Ions ; Lasers ; *Mass Spectrometry/instrumentation/methods
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  • 10
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    Studying enzyme mechanism by 13C nuclear magnetic resonance (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-31
    Description: High-resolution carbon-13 nuclear magnetic resonance (NMR) spectra of enzyme-inhibitor and enzyme-substrate complexes provide detailed structural and stereochemical information on the mechanism of enzyme action. The proteases trypsin and papain are shown to form tetrahedrally coordinated complexes and acyl derivatives with a variety of compounds artificially enriched at the site or sites of interest. These results are compared with the structural information derived from x-ray diffraction. Detailed NMR studies have provided a clearer picture of the ionization state of the residues participating in enzyme-catalyzed processes than other more classical techniques. The dynamics of enzymic catalysis can be observed at sub-zero temperatures by a combination of cryoenzymology and carbon-13 NMR spectroscopy. With these powerful techniques, transient, covalently bound intermediates in enzyme-catalyzed reactions can be detected and their structures rigorously assigned.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mackenzie, N E -- Malthouse, J P -- Scott, A I -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):883-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6433481" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Carbon Isotopes ; Carboxypeptidases/metabolism ; Carboxypeptidases A ; Catalysis ; Chemical Phenomena ; Chemistry ; Coenzymes/*metabolism ; Endopeptidases/metabolism ; Enzymes/*metabolism ; Freezing ; Fructose-Bisphosphate Aldolase/metabolism ; Magnetic Resonance Spectroscopy ; Papain/metabolism ; Pepsin A/metabolism ; Peptide Hydrolases/*metabolism ; Protease Inhibitors ; Pterins/metabolism ; Pyridoxal Phosphate/metabolism ; Serine Endopeptidases
    Print ISSN: 0036-8075
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  • 11
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    What is the risk from chlorofluorocarbons? (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1051-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695193" target="_blank"〉PubMed〈/a〉
    Keywords: *Air Pollutants ; *Atmosphere ; Carbon Tetrachloride ; Chemical Phenomena ; Chemistry ; *Chlorofluorocarbons, Methane ; Free Radicals ; Nitrogen Dioxide ; Nitrous Oxide ; Oxygen ; *Ozone ; Photochemistry ; Risk ; Singlet Oxygen ; Trichloroethanes ; Ultraviolet Rays
    Print ISSN: 0036-8075
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  • 12
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    Pyrolysis mass spectrometry of complex organic materials (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-19
    Description: Pyrolysis mass spectrometry in combination with computerized multivariate statistical analysis enables qualitative and quantitative analysis of nonvolatile organic materials containing molecular assemblies of a complexity and size far beyond the capabilities of direct mass spectrometry. The state of the art in pyrolysis mass spectrometry techniques is illustrated through specific applications, including structural determination and quality control of synthetic polymers, quantitative analysis of polymer mixtures, classification and structural characterization of fossil organic matter, and nonsupervised numerical extraction of component patterns from complex biological samples.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meuzelaar, H L -- Windig, W -- Harper, A M -- Huff, S M -- McClennen, W H -- Richards, J M -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):268-74.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6484572" target="_blank"〉PubMed〈/a〉
    Keywords: Biochemical Phenomena ; Biochemistry ; Chemical Phenomena ; Chemistry ; Coal ; Enterobacteriaceae/analysis/isolation & purification ; Hot Temperature ; Mass Spectrometry/*methods ; Polymers
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  • 13
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    Lariat RNA's as intermediates and products in the splicing of messenger RNA precursors (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-31
    Description: The splicing of messenger RNA precursors in vitro proceeds through an intermediate that has the 5' end of the intervening sequence joined to a site near the 3' splice site. This lariat structure, which has been characterized for an adenovirus 2 major late transcript, has a branch point, with 2'-5' and 3'-5' phosphodiester bonds emanating from a single adenosine residue. The excised intervening sequence retains the branch site and terminates in a guanosine residue with a 3' hydroxyl group. The phosphate group at the splice junction between the two exons originates from the 3' splice site at the precursor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Padgett, R A -- Konarska, M M -- Grabowski, P J -- Hardy, S F -- Sharp, P A -- P01-CA14051/CA/NCI NIH HHS/ -- P01-CA26717/CA/NCI NIH HHS/ -- R01-GM32467/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):898-903.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6206566" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoviruses, Human/metabolism ; Base Sequence ; Chemical Phenomena ; Chemistry ; Nucleic Acid Conformation ; Nucleic Acid Precursors/analysis/*metabolism ; Oligoribonucleotides/metabolism ; Phosphates/metabolism ; RNA/analysis/*metabolism ; RNA Precursors ; *RNA Splicing ; RNA, Messenger/analysis/*metabolism ; RNA, Viral/analysis/*metabolism
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  • 14
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    beta-Carotene: an unusual type of lipid antioxidant (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-11
    Description: The mechanism of lipid peroxidation and the manner in which antioxidants function is reviewed. beta-Carotene is a purported anticancer agent, which is believed by some to have antioxidant action of a radical-trapping type. However, definitive experimental support for such action has been lacking. New experiments in vitro show that beta-carotene belongs to a previously unknown class of biological antioxidants. Specifically, it exhibits good radical-trapping antioxidant behavior only at partial pressures of oxygen significantly less than 150 torr, the pressure of oxygen in normal air. Such low oxygen partial pressures are found in most tissues under physiological conditions. At higher oxygen pressures, beta-carotene loses its antioxidant activity and shows an autocatalytic, prooxidant effect, particularly at relatively high concentrations. Similar oxygen-pressure-dependent behavior may be shown by other compounds containing many conjugated double bonds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burton, G W -- Ingold, K U -- New York, N.Y. -- Science. 1984 May 11;224(4649):569-73.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710156" target="_blank"〉PubMed〈/a〉
    Keywords: Antioxidants/*metabolism ; Carotenoids/*metabolism ; Chemical Phenomena ; Chemistry ; Free Radicals ; Humans ; Linoleic Acids/metabolism ; *Lipid Metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Partial Pressure ; Peroxides/metabolism ; Tetrahydronaphthalenes/metabolism ; beta Carotene
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  • 15
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    Bromine residue at hydrophilic region influences biological activity of aplysiatoxin, a tumor promoter (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-16
    Description: Aplysiatoxin and debromoaplysiatoxin, which are isolated from the seaweed, Lyngbya gracilis, differ in their chemical structure only by the presence or absence of a bromine residue in the hydrophilic region. The function and the structure-activity relation of the hydrophilic region are not known. Aplysiatoxin increased malignant transformation, stimulated DNA synthesis, and inhibited the binding of phorbol-12,13-dibutyrate and epidermal growth factor to cell receptors. Debromoaplysiatoxin inhibited the binding of these two substances as strongly as aplysiatoxin but did not increase malignant transformation or stimulate DNA synthesis. These results indicate that a slight change in the chemical structure of the hydrophilic region of aplysiatoxin affects its abilities to increase cell transformation and stimulate DNA synthesis and that the abilities of the tumor promoters to inhibit the binding of phorbol-12,13-dibutyrate and epidermal growth factor are dissociable from their abilities to increase cell transformation and stimulate DNA synthesis under some circumstances.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shimomura, K -- Mullinix, M G -- Kakunaga, T -- Fujiki, H -- Sugimura, T -- New York, N.Y. -- Science. 1983 Dec 16;222(4629):1242-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316505" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Caenorhabditis elegans Proteins ; Carcinogens/*pharmacology ; Carrier Proteins ; Cell Line ; Cell Transformation, Neoplastic/*drug effects ; Chemical Phenomena ; Chemistry ; DNA/biosynthesis ; Epidermal Growth Factor/metabolism ; Lactones/analysis/*pharmacology ; *Lyngbya Toxins ; Mice ; Phorbol 12,13-Dibutyrate ; Phorbol Esters/metabolism ; *Protein Kinase C ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/metabolism ; *Receptors, Drug ; Structure-Activity Relationship
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  • 16
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    Phenylalanine transfer RNA: molecular dynamics simulation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-16
    Description: Yeast phenylalanine transfer RNA was subjected to a 12-picosecond molecular dynamics simulation. The principal features of the x-ray crystallographic analysis are reproduced, and the amplitudes of atomic displacements appear to be determined by the degree of exposure of the atoms. An analysis of the hydrogen bonds shows a correlation between the average length of a bond and the fluctuation in that length and reveals a rocking motion of bases in Watson-Crick guanine X cytosine base pairs. The in-plane motions of the bases are generally of larger amplitude than the out-of-plane motions, and there are correlations in the motions of adjacent bases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harvey, S C -- Prabhakaran, M -- Mao, B -- McCammon, J A -- New York, N.Y. -- Science. 1984 Mar 16;223(4641):1189-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6560785" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Computers ; Cytosine ; Guanine ; Hydrogen Bonding ; Nucleic Acid Conformation ; *RNA, Fungal ; *RNA, Transfer, Amino Acyl ; Yeasts/analysis
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  • 17
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    Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-16
    Description: Sequence-dependent variations in DNA revealed by x-ray crystallographic studies have suggested that certain DNA-reactive drugs may react preferentially with defined sequences in DNA. Drugs that wind around the helix and reside within one of the grooves of DNA have perhaps the greatest chance of recognizing sequence-dependent features of DNA. The antitumor antibiotic CC-1065 covalently binds through N-3 of adenine and resides within the minor groove of DNA. This drug overlaps with five base pairs for which a high sequence specificity exists.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hurley, L H -- Reynolds, V L -- Swenson, D H -- Petzold, G L -- Scahill, T A -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):843-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494915" target="_blank"〉PubMed〈/a〉
    Keywords: Antibiotics, Antineoplastic/*metabolism ; *Base Sequence ; Binding Sites ; Chemical Phenomena ; Chemistry ; DNA/*metabolism ; *Indoles ; Leucomycins/*metabolism ; Molecular Conformation ; X-Ray Diffraction
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  • 18
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    Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-15
    Description: A new class of synthetic antifungal agents, the allylamines , has been developed by modification of naftifine , a topical antimycotic. SF 86-327, the most effective of these compounds so far, is highly active in vitro against a wide range of fungi and exceeds clinical standards in the oral and topical treatment of guinea pig dermatophytoses. SF 86-327 is a powerful specific inhibitor of fungal squalene epoxidase, a key enzyme in sterol biosynthesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petranyi, G -- Ryder, N S -- Stutz, A -- New York, N.Y. -- Science. 1984 Jun 15;224(4654):1239-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6547247" target="_blank"〉PubMed〈/a〉
    Keywords: Allylamine/analogs & derivatives/*chemical synthesis/pharmacology ; Amines/*chemical synthesis ; Animals ; Antifungal Agents/*chemical synthesis/pharmacology ; Chemical Phenomena ; Chemistry ; Dermatomycoses/drug therapy ; Fungi/*drug effects/enzymology ; Guinea Pigs ; Naphthalenes/chemical synthesis/pharmacology ; Oxygenases/*antagonists & inhibitors ; Squalene Monooxygenase
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 19
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    Disulfide bond engineered into T4 lysozyme: stabilization of the protein toward thermal inactivation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-02
    Description: By recombinant DNA techniques, a disulfide bond was introduced at a specific site in T4 lysozyme, a disulfide-free enzyme. This derivative retained full enzymatic activity and was more stable toward thermal inactivation than the wild-type protein. The derivative, T4 lysozyme (Ile3----Cys), was prepared by substituting a Cys codon for an Ile codon at position 3 in the cloned lysozyme gene by means of oligonucleotide-dependent, site-directed mutagenesis. The new gene was expressed in Escherichia coli under control of the (trp-lac) hybrid tac promoter, and the protein was purified. Mild oxidation generated a disulfide bond between the new Cys3 and Cys97, one of the two unpaired cysteines of the native molecule. Oxidized T4 lysozyme (Ile3----Cys) exhibited specific activity identical to that of the wild-type enzyme when measured at 20 degrees C in a cell-clearing assay. The cross-linked protein was more stable than the wild type during incubation at elevated temperatures as determined by recovered enzymatic activity at 20 degrees C.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perry, L J -- Wetzel, R -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):555-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6387910" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; DNA, Recombinant/metabolism ; Escherichia coli/enzymology ; *Genetic Engineering ; Kinetics ; Muramidase/*genetics/metabolism ; Protein Denaturation
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  • 20
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    DNA-binding proteins (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-09-09
    Description: The structures of three proteins that regulate gene expression have been determined recently and suggest how these proteins may bind to their specific recognition sites on the DNA. One protein (Cro) is a repressor of gene expression, the second (CAP) usually stimulates gene expression, and the third (lambda repressor) can act as either a repressor or an activator. The three proteins contain a substructure consisting of two consecutive alpha helices that is virtually identical in each case. Structural and amino acid sequence comparisons suggest that this bihelical fold occurs in a number of proteins that regulate gene expression, and is an intrinsic part of the DNA-protein recognition event. The modes of repression and activation by Cro and lambda repressor are understood reasonably well, but the mode of action of CAP is still unclear.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Takeda, Y -- Ohlendorf, D H -- Anderson, W F -- Matthews, B W -- GM20066/GM/NIGMS NIH HHS/ -- GM28138/GM/NIGMS NIH HHS/ -- GM30894/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1020-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6308768" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Chemical Phenomena ; Chemistry ; *DNA Helicases ; DNA-Binding Proteins ; Escherichia coli/genetics ; Gene Expression Regulation ; Models, Chemical ; Protein Conformation
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  • 21
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    A nitrogen pressure of 50 atmospheres does not prevent evolution of hydrogen by nitrogenase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-08
    Description: The effect of a partial pressure of nitrogen of 50 atmospheres (5065 kilopascals ) on the hydrogen evolution reaction of nitrogenase has been investigated. Evolution of hydrogen was not blocked completely by 50 atmospheres of nitrogen in any of four experiments; rather, 27.3 +/- 2.4 percent of the total electron flux through nitrogenase was directed toward production of hydrogen. The ratio of hydrogen evolved to nitrogen fixed was close to 1:1, which implies that hydrogen evolution is obligatory in the fixation of molecular nitrogen by nitrogenase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simpson, F B -- Burris, R H -- AI-00848/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1095-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6585956" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Hydrogen ; *Nitrogen ; Nitrogen Fixation ; *Nitrogenase ; Partial Pressure
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    Foreign aid support of science and economic growth (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-17
    Description: The history of U.S. foreign aid support of science and technology in Latin America is examined and an attempt is made to evaluate the scientific and economic growth of that area in relation to the total foreign aid effort.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Szmant, H H -- New York, N.Y. -- Science. 1978 Mar 17;199(4334):1173-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/415363" target="_blank"〉PubMed〈/a〉
    Keywords: Chemistry ; Cost-Benefit Analysis ; Education ; History, 20th Century ; International Educational Exchange ; Latin America ; *Research Support as Topic ; *Science/history ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 23
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    Nonvolatile mutagens in drinking water: production by chlorination and destruction by sulfite (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-04
    Description: In concentrates of water produced in a laboratory simulation of a drinking water treatment process, direct-acting, nonvolatile mutagens were readily detected by means of the Ames Salmonella test. The mutagens were shown to be produced by the chlorination process. Treatment of the water with chloramine resulted in less mutagenic activity than treatment with free chlorine. Dechlorination of drinking water with sulfite sharply reduced the mutagenic activity. Treatment with sulfur dioxide is proposed as an effective, inexpensive method of reducing the direct-acting mutagenic activity of drinking water and of aqueous industrial effluents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cheh, A M -- Skochdopole, J -- Koski, P -- Cole, L -- New York, N.Y. -- Science. 1980 Jan 4;207(4426):90-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6985746" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Chloramines ; Chlorine ; Mutagens/*analysis ; Salmonella typhimurium/genetics ; Sulfites ; Water Pollutants/*analysis ; Water Pollutants, Chemical/*analysis ; Water Supply/*analysis
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    Automated synthesis of gene fragments (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-10-16
    Description: The DNA/RNA Synthesizer provides a complete and automated procedure for the synthesis of DNA sequences. Each base unit is added in a 30-minute cycle, permitting a tetradecamer to be constructed in 6 1/2 hours. The complete procedure is described, including a practical procedure for isolation and purification of the desired DNA sequence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alvarado-Urbina, G -- Sathe, G M -- Liu, W C -- Gillen, M F -- Duck, P D -- Bender, R -- Ogilvie, K K -- New York, N.Y. -- Science. 1981 Oct 16;214(4518):270-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6169150" target="_blank"〉PubMed〈/a〉
    Keywords: Automation ; Chemical Phenomena ; Chemistry ; DNA/*chemical synthesis ; *Genes, Synthetic ; RNA/*chemical synthesis ; Solubility
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    Chitin: New facets of research (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-15
    Description: Research on chitin as a marine resource is pointing to novel applications for this cellulose-like biopolymer. Discovery of nondegrading solvent systems has permitted the spinning of filaments, for example, for use as surgical sutures. New methods for preparing the bioactive alkyl glycoside of N-acetyl-D-glucosamine (the monomer unit of chitin) and a microcrystalline chitin has encouraged their use as promoters for growth of bifidobacteria and as an aid in digestion of high-lactose cheese whey by domestic animals. Chitin-protein complexes of several crustacean species show great variability in ratios of chitin to covalently bound protein and in residual protein in the "purified" chitins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Austin, P R -- Brine, C J -- Castle, J E -- Zikakis, J P -- New York, N.Y. -- Science. 1981 May 15;212(4496):749-53.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7221561" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Feed ; Animals ; Cheese ; Chemical Phenomena ; Chemistry ; Chickens ; *Chitin ; Crystallography ; Lactose/metabolism ; Proteins/analysis ; Sutures ; *Technology
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    DNA sequencing and gene structure (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gilbert, W -- New York, N.Y. -- Science. 1981 Dec 18;214(4527):1305-12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7313687" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Chemical Phenomena ; Chemistry ; DNA/*genetics ; Eukaryotic Cells/physiology ; *Genes ; Hydrazines ; Lac Operon ; Methylation ; Prokaryotic Cells/physiology ; Sulfuric Acid Esters
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  • 27
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    Boradeption: a new procedure for transferring water-insoluble agents across cell membranes (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-09
    Description: A new process has been developed which is called "Boradeption" to signify boronic acid--dependent phase transfer of water-insoluble agents. Highly fluorescent boronic acid dervatives, FluoroBoras, are solubilized with a physiologically compatible carrier buffer containing a receptor group for boronate adduct formation. The system can be used to stain living cells. In another variation of the Boradeption concept, an insoluble reporter molecule containing a boronate receptor is solubilized with a carrier buffer containing a boronic acid functional group. The boronate-receptor complexes, which are in dynamic equilibrium, can be designed as vital stains and reagents for a variety of biological and medical applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallop, P M -- Paz, M A -- Henson, E -- AG-00376-07/AG/NIA NIH HHS/ -- HL-20764-04A1/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):166-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178158" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Transport ; *Boron Compounds/therapeutic use ; *Boronic Acids/therapeutic use ; *Cell Membrane Permeability ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Chromogenic Compounds/metabolism ; Cricetinae ; Fibroblasts ; Fluorescent Dyes/metabolism ; Humans ; Rats ; Staining and Labeling
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    Reversible chemical modification of the scrapie agent (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-12-11
    Description: The scrapie agent causes a degenerative nervous system disease in sheep and goats. Studies with extensively purified preparations demonstrated that the agent contains a protein that is required for infectivity. Chemical modification of the scrapie agent by diethyl pyrocarbonate reduced the titer 1000-fold. Exposure of the inactivated agent to hydroxylamine, a strong nucleophile, resulted in complete restoration of infectivity. Presumably, nucleophilic residues within a scrapie agent protein undergo carbethoxylation on reaction with diethyl pyrocarbonate, and subsequent addition of hydroxylamine displaces these carbethoxy groups.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McKinley, M P -- Masiarz, F R -- Prusiner, S B -- NS14069/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1259-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6795721" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Assay ; Brain/microbiology ; Chemical Phenomena ; Chemistry ; Cricetinae ; Diethyl Pyrocarbonate/pharmacology ; Histidine/pharmacology ; *Prions ; Ribonucleases/pharmacology ; Serum Albumin, Bovine/pharmacology ; Viral Proteins/*isolation & purification/pharmacology
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  • 29
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    Nonenzymatic browning in vivo: possible process for aging of long-lived proteins (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-30
    Description: The incubation of lens proteins with reducing sugars leads to the formation of fluorescent yellow pigments and cross-like similar to those reported in aging and cataractous human lenses. Called nonenzymatic browning or the Maillard reaction, this aging process also occurs in stored foods. Reducing sugars condense with the free amino group of proteins, then rearrange and dehydrate to form unsaturated pigments and cross-linked products. Although most proteins in living systems turn over with sufficient rapidity to avoid nonenzymatic browning, some, such as lens crystallins and skin collagen, are exceptionally long-lived and may be vulnerable.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Monnier, V M -- Cerami, A -- AM 19655/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Jan 30;211(4481):491-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6779377" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Cattle ; Chemical Phenomena ; Chemistry ; *Crystallins ; Diabetes Mellitus/physiopathology ; Glucose ; Glucosephosphates ; In Vitro Techniques ; Lysine ; *Proteins ; Spectrophotometry, Ultraviolet
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    The National Science Foundation looks to the future (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-03-13
    Description: Great advances have been made in fundamental scientific research in recent years. The new knowledge gathered, in addition to deepening our understanding of the physical universe, contributes a range of abilities and opportunities to society that would not otherwise be available. Much research that may be called applied because it addresses needs of society is quite fundamental in character, and support of such research at the National Science Foundation is to be handled in tandem by the research directorates. Other areas that require a refocusing of support are engineering science and education, at all levels, in science and engineering. Increasing our strength in these areas is essential to achieve our national economic, social, and political goals. Steps are being taken by the National Science Foundation to make its structure better able to deal with engineering and applied research and to provide greater mutual reinforcement between applied and basic research.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slaughter, J B -- New York, N.Y. -- Science. 1981 Mar 13;211(4487):1131-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466384" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Biology ; Chemical Phenomena ; Chemistry ; *Forecasting ; Geological Phenomena ; Geology ; *Government Agencies ; Molecular Biology ; Neurochemistry ; Physical Phenomena ; Physics ; Research Support as Topic ; United States
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    New chemistry of an old molecule: cis-[Pt(NH3)2Cl2] (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-10
    Description: The discovery that cis-diamminedichloroplatinum(II) (cis-DDP) has clinically useful antitumor properties and can form platinum blues spawned an extensive investigation of its chemistry in water. Several new molecules have been synthesized, some rather old ones have been characterized for the first time, and clues have begun to emerge about the chemical interaction of cis-DDP with its likely biological target, DNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lippard, S J -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1075-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6890712" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Cisplatin ; *Dna ; Hydrolysis ; Pigments, Biological
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  • 32
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    The chemistry of vision (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-03
    Description: The visual response is initiated by light reception and transduction into chemical and electrical energy in the outer-segment membranes of rod and cone cells. Recent research on the molecular events controlled by light has clarified the roles of some of the rod outer-segment biomolecules. These developments and the current unresolved questions are described.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Brien, D F -- New York, N.Y. -- Science. 1982 Dec 3;218(4576):961-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6291153" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Proteins/metabolism ; Calcium/metabolism ; Chemical Phenomena ; Chemistry ; Enzyme Activation ; Enzymes/metabolism ; GTP-Binding Proteins ; Light ; Membranes/metabolism ; Models, Biological ; Phosphoric Diester Hydrolases/biosynthesis ; Photoreceptor Cells/*metabolism ; Receptors, Cell Surface/metabolism ; Rhodopsin/metabolism ; Rod Cell Outer Segment/*metabolism ; Vision, Ocular/*physiology
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    Antiviral agents (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-06-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krenitsky, T A -- Beauchamp, L -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1106.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857236" target="_blank"〉PubMed〈/a〉
    Keywords: Acyclovir/metabolism ; *Antiviral Agents/metabolism ; Chemical Phenomena ; Chemistry ; Humans ; Vidarabine/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Metastable species of hemoglobin: room temperature transients and cryogenically trapped intermediates (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-06
    Description: Resonance Raman spectra of photolyzed carbonmonoxyhemoglobin obtained with 10-nanosecond pulses are compared with the spectra of photolyzed carbonmonoxyhemoglobin stabilized at 80 K. In comparing the deoxy with the photodissociated species, the changes in the Raman spectra are the same for these two experimental regimes. These results show that at ambient and cryogenic temperatures the heme pocket in liganded hemoglobin is significantly different from that of deoxyhemoglobin. It is concluded that measurements of the properties of intermediate species from photodissociated hemoglobin stabilized at low temperatures can be used to probe the short-lived metastable forms of hemoglobin present after photodissociation under biologically relevant solution conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ondrias, M R -- Friedman, J M -- Rousseau, D L -- New York, N.Y. -- Science. 1983 May 6;220(4597):615-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836305" target="_blank"〉PubMed〈/a〉
    Keywords: Carboxyhemoglobin ; Chemical Phenomena ; Chemistry ; Freezing ; *Hemoglobins ; Humans ; Ligands ; Spectrum Analysis, Raman ; Temperature
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Irreversible ligands with high selectivity toward delta and mu opiate receptors (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-04-15
    Description: Alkylating agents that display strong selectivity for opiate receptor types delta or mu were prepared by appropriate modification of the structures of the strong analgesics fentanyl, etonitazene, and endoethenotetrahydrooripavine. The availability of these substances should facilitate studies of the structural basis of receptor specificity and of the physiologic roles of these receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rice, K C -- Jacobson, A E -- Burke, T R Jr -- Bajwa, B S -- Streaty, R A -- Klee, W A -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):314-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6132444" target="_blank"〉PubMed〈/a〉
    Keywords: Alkylation ; Animals ; Benzimidazoles/analogs & derivatives/metabolism ; Brain/physiology ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Enkephalin, Methionine/analogs & derivatives/metabolism ; Fentanyl/analogs & derivatives/metabolism ; *Isothiocyanates ; Ligands ; Rats ; Receptors, Opioid/*metabolism/physiology ; Thebaine/analogs & derivatives/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 36
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    The glycosylation of hemoglobin: relevance to diabetes mellitus (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-07
    Description: Glucose reacts nonenzymatically with the NH2-terminal amino acid of the beta chain of human hemoglobin by way of a ketoamine linkage, resulting in the formation of hemoglobin AIc. Other minor components appear to be adducts of glucose 6-phosphate and fructose 1,6-diphosphate. These hemoglobins are formed slowly and continuously throughout the 120-day life-span of the red cell. There is a two- to threefold increase in hemoglobin AIc in the red cells of patients with diabetes mellitus. By providing an integrated measurement of blood glucose, hemoglobin AIc is useful in assessing the degree of diabetic control. Furthermore, this hemoglobin is a useful model of nonenzymatic glycosylation of other proteins that may be involved in the long-term complications of the disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bunn, H F -- Gabbay, K H -- Gallop, P M -- New York, N.Y. -- Science. 1978 Apr 7;200(4337):21-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/635569" target="_blank"〉PubMed〈/a〉
    Keywords: Blood Glucose/metabolism ; Chemical Phenomena ; Chemistry ; Diabetes Complications ; Diabetes Mellitus/*blood/diagnosis ; Diphosphoglyceric Acids/blood ; Glycosides/blood ; Glycosuria/etiology ; Hemoglobin A/*metabolism ; Hemoglobins/*analysis/*metabolism ; Humans ; Kinetics ; Oxygen/blood ; Structure-Activity Relationship
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    N-formyliminodiacetic acid, a new compound from the reaction of nitrilotriacetic acid and chlorine (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-08
    Description: It has been proposed that nitrilotriacetic acid be substituted for trisodium polyphosphates in detergents as a way to reduce the rate of eutrophication in the Great Lake Basin. The reaction of nitrilotriacetic acid with chlorine-containing solutions produces a hitherto unknown degradation production, N-formyliminodiacetic acid, in high yield. The toxicological and environmental implications of this reaction are unclear.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spanggord, R J -- Tyson, C A -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1081-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/36659" target="_blank"〉PubMed〈/a〉
    Keywords: *Acetates ; Chemical Phenomena ; Chemistry ; *Chlorine ; Dicarboxylic Acids ; Environmental Pollutants ; Hydrogen-Ion Concentration ; *Imino Acids ; Mutagens ; *Nitrilotriacetic Acid
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 38
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    HCN did not condense to give heteropolypeptides on the primitive earth (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ferris, J P -- New York, N.Y. -- Science. 1979 Mar 16;203(4385):1135-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/218287" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Hydrogen Cyanide ; *Peptides
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 39
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    Trace chemistries of fire: a source of chlorinated dioxins (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bumb, R R -- Crummett, W B -- Cutie, S S -- Gledhill, J R -- Hummel, R H -- Kagel, R O -- Lamparski, L L -- Luoma, E V -- Miller, D L -- Nestrick, T J -- Shadoff, L A -- Stehl, R H -- Woods, J S -- New York, N.Y. -- Science. 1980 Oct;210(4468):385-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6159682" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollutants/analysis ; Chemical Phenomena ; Chemistry ; Chromatography, High Pressure Liquid ; *Dioxins/analysis ; *Fires ; Power Plants ; Smoke/analysis ; Soil Pollutants/analysis ; Tetrachlorodibenzodioxin/analysis ; Vehicle Emissions/analysis ; Water Pollutants, Chemical/analysis
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 40
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    Synthetic competitive antagonists of corticotropin-releasing factor: effect on ACTH secretion in the rat (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-25
    Description: Polypeptide analogs of the known members of the corticotropin-releasing factor (CRF) family were synthesized and tested in vitro and in vivo for enhanced potency or competitive antagonism. Predictive methods and physicochemical measurements had suggested an internal secondary alpha-helical conformation spanning about 25 residues for at least three members of the CRF family. Maximization of alpha-helix-forming potential by amino acid substitutions from the native known sequences (rat/human and ovine CRF, sauvagine, and carp and sucker urotensin 1) led to the synthesis of an analog that was found to be more than twice as potent as either of the parent peptides in vitro. In contrast, certain amino-terminally shortened fragments, such as alpha-helical CRF or ovine CRF residues 8 to 41, 9 to 41, and 10 to 41, were found to be competitive inhibitors in vitro. Selected antagonists were examined and also found to be active in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rivier, J -- Rivier, C -- Vale, W -- AA03504/AA/NIAAA NIH HHS/ -- AM20917/AM/NIADDK NIH HHS/ -- AM26741/AM/NIADDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 May 25;224(4651):889-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6326264" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/secretion ; Animals ; Binding, Competitive ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone/*antagonists & inhibitors ; Rats
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 41
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    Motions of a liquid in a pulsating bulb with application to problems of blood flow (1976)
    In:  CASI
    Details
    Publication Date: 2010-11-08
    Description: Potential flows may be utilized to represent motions produced in pulsating bulbs. While the initial bulb shape may be arbitrary, sequential shapes are related by affine transformations. Two components appear in the distribution of pressure, one dependent on the instantaneous velocity and the other on the acceleration. For flows with stationary streamlines the inertial impedance is that of a simple mass, and is proportional to the first moment of the actual mass of fluid contained within the bulb. Examples treated are: (1) Expanding and collapsing circular cylinders, and (2) elliptical cylinders in which the perimeter is held constant. The thickness of the pulsatile laminar boundary layer is found to be approximately on millimeter for conditions in the vicinity of the heart. Conditions for separation and turbulence differ from those in steady flow.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: NASA. Ames Res. Center Collected Works of Robert T. Jones; p 957-965
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  • 42
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    Investigation B: Laminar confined coaxial entrance flow with heat generation (1975)
    In:  CASI
    Details
    Publication Date: 2009-11-16
    Description: The results of a parametric study on the entrance flow region in a gas core nuclear reactor are presented. The physical system is modeled as laminar confined, coaxial flow with heat generation in the inner fluid. The governing equations include the boundary layer approximations and the assumptions of only radial radiative transport of energy represented as an energy diffusion term. The Von Mises transformation and a zeta transformation are used to transform the equations into nonlinear nonhomogeneous convective-diffusion equations. A unique combination of forward and backward difference equations which yields accurate results at moderate computational times, is used in the numerical method. Results show that the rapidly accelerating, heat generating inner stream actually shrinks in radius as it expands axially.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Turbulence Coefficients and Stability Studies for the Coaxial Flow or Dissimiliar Fluids; 76 p
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  • 43
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    A numerical comparison with an exact solution for the transient response of a cylinder immersed in a fluid (1979)
    In:  CASI
    Details
    Publication Date: 2006-07-02
    Description: The transient response of an elastic cylindrical shell immersed in an acoustic media that is engulfed by a plane wave is determined numerically. The method applies to the USA-STAGS code which utilizes the finite element method for the structural analysis and the doubly asymptotic approximation for the fluid-structure interaction. The calculations are compared to an exact analysis for two separate loading cases: a plane step wave and an exponentially decaying plane wave.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Shock and Vibration Inform. Center The Shock and Vibration Bull., Pt. 3; p 23-28
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  • 44
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    Effect of shear stress on cell cultures and other reactor problems (1981)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Anchorage dependent cell cultures in fluidized beds are tested. Feasibility calculations indicate the allowed parameters and estimate the shear stresses therein. In addition, the diffusion equation with first order reaction is solved for the spherical shell (double bubble) reactor with various constraints.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Houston Univ. The 1981 NASA ASEE Summer Fac. Fellowship Program, Vol. 2; 19 p
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  • 45
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    Full-coverage film cooling (1982)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Transpiration cooling is treated and then full coverage discrete hole injection for three injection orientations. Spacings with pitch to diameter ratios of 5 and 10 are discussed. The array is staggered, with the transverse pitch and the streamwise pitch the same. Results are presented in terms of the Stanton number using the heat transfer coefficient defined in terms of the difference between the wall temperature and the free stream temperature. Two values of Stanton number are provided for each situation: one with the injectant at wall temperature, and the other with the injectant at free stream temperature. These two values are equivalent to knowing the heat transfer coefficient and the adiabatic effectiveness. The heat transfer coefficient thus defined is used with the actual wall temperature to and the actual gas temperature to calculate the heat load. The principle of superposition thus invoked is valid exactly when the governing equations are linear.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Von Karman Inst. for Fluid Dyn. Film Cooling and Turbine Blade Heat Transfer, Vol. 1; 27 p
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  • 46
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    Application of fluidics to new control components (1978)
    In:  CASI
    Details
    Publication Date: 2006-03-02
    Description: The inherent tolerance for nuclear radiation makes fluidic devices candidates for nuclear rocket control systems. Also, they are being considered for supersonic jet engine inlet control because of their high temperature and vibration tolerance. Three new control components being considered for these applications are described. A fluidic circuit to control a pneumatic stepping motor for nuclear rocket control drum actuation is discussed. An all-fluidic sensor being developed for determining the position of the normal shock in the inlet of a supersonic jet engine is outlined. A new vortex valve configuration is developed to prevent supersonic jet engine inlet unstarts by regulating bypass flow.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: NASA, Washington Fourth Inter-Center Control Systems Conf.; p 365-386
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  • 47
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    Capillary priming characteristics of a dual passage heat pipe in zero-g (1981)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Technical improvements of a long life heat rejection system, suitable for long duration high power missions, that can be constructed and deployed in orbit is discussed. A mathematical model is formulated and a computer program developed which describes the transient priming characteristics of a dual passage heat pipe. An experimental test package is described for flight in the KC-135 Zero-g Aircraft, to be used to verify the modeling predictions.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Houston Univ. The 1981 NASA ASEE Summer Fac. Fellowship Program, Vol. 2; 50 p
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  • 48
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    Flow phenomena peculiar to calculation of compressible turbulent boundary layers (1977)
    In:  CASI
    Details
    Publication Date: 2006-01-16
    Description: Calculation procedures for compressible turbulent boundary layers were based upon techniques, modeling constants, etc., developed originally for the low speed case. Significant differences and new or altered physics which occur in the compressible case were considered, as compared with the low speed situation. Possible pitfalls and sources of inaccuracy in the calculations were indicated.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Calculation Methods for Compressible Turbulent Boundary Layers, 1976; p 9-46
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  • 49
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    Surface-tension-induced convection experiment MA-041 (1976)
    In:  CASI
    Details
    Publication Date: 2006-01-12
    Description: In the absence of gravity, stirring in a liquid is suppressed because of density differences caused by thermal or compositional gradients. However, other mechanisms resulting in natural convection in a microgravity environment exist. One of the most important mechanisms for liquid metals is surface tension driven convection, which becomes predominant in the low gravity environment. In this case, surface tension differences caused by compositional or temperature gradients have been demonstrated to cause stirring in liquids during experiments performed onboard Skylab. Compositional gradients were created by adding a soap solution to a large water globule, which caused vigorous fluid motion for some moments after the addition.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: NASA. Lyndon B. Johnson Space Center Apollo-Soyuz Test Project; 11 p
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  • 50
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    Summary of calculation procedures for nonsimilar two- and three-dimensional compressible turbulent boundary layers (finite difference, finite element and weighted residual methods), appendix (1977)
    In:  CASI
    Details
    Publication Date: 2006-01-16
    Description: This numerical prediction summary indicates the wide variety of such procedures which are available. Most procedures have detailed user manuals, and in many cases the codes are available. Many of the special effects treated by various methods (such as nonequilibrium or equilibrium chemistry, transition, roughness etc.) are indicated.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Calculation Methods for Compressible Turbulent Boundary Layers, 1976; p 69-78
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  • 51
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    Calculation of three-dimensional compressible turbulent boundary layers (1977)
    In:  CASI
    Details
    Publication Date: 2006-01-16
    Description: From comparisons of high speed data with low speed closure procedures using variable mean density, there does not appear to be any appreciable influence of compressibility upon turbulent shear stress modeling in compressible turbulent boundary layers, even for extreme cases such as Mach 14 to 20 with a change in density across the layer of up to a factor of 100. Other evidence of apparent lack of compressibility caused new physics which may alter the shear stress for the compressible boundary layer cases including: (1) fluctuation Mach number was generally less than 1; (2) the shear stress distribution through the boundary layer was not a function of Mach number for zero pressure gradient flows; (3) the Morkovin hypothesis was valid up to Mach 5 (based on fluctuation data); (4) profile N power was not a function of Mach number, at least up to Mach 10; and (5) the nondimensional burst period was approximately the same as that for low speed.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Calculation Methods for Compressible Turbulent Boundary Layers, 1976; p 47-68
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  • 52
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    Equations and closure methods (1977)
    In:  CASI
    Details
    Publication Date: 2006-01-16
    Description: Basic differential equations governing compressible turbulent boundary layer flow are reviewed, including conservation of mass and energy, momentum equations derived from Navier-Stokes equations, and equations of state. Closure procedures were broken down into: (1) simple or zeroth-order methods, (2) first-order or mean field closure methods, and (3) second-order or mean turbulence field methods.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Calculation Methods for Compressible Turbulent Boundary Layers, 1976; p 6-8
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  • 53
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    Science demonstrations (1976)
    In:  CASI
    Details
    Publication Date: 2006-01-12
    Description: Three demonstrations of scientific concepts concerning liquids were performed during the Apollo-Soyuz Test Project mission. Chemical foaming, spreading of liquids, and capillary wicking were the subjects of each demonstration photographed in space. The results clearly illustrated the basic principles, and films suitable for educational uses are now available from the first author.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Apollo-Soyuz Test Project; 9 p
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  • 54
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    Heat loss and drag of spherical drop tube samples (1982)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Analysis techniques for three aspects of the performance of the NASA/MSFC 32 meter drop tube are considered. Heat loss through the support wire in a pendant drop sample, temperature history of a drop falling through the drop tube when the tube is filled with helium gas at various pressures, and drag and resulting g-levels experienced by a drop falling through the tube when the tube is filled with helium gas at various pressures are addressed. The developed methods apply to systems with sufficiently small Knudsen numbers for which continuum theory may be applied. Sample results are presented, using niobium drops, to indicate the magnitudes of the effects. Helium gas at one atmosphere pressure can approximately double the amount of possible undercooling but it results in an apparent gravity levels of up to 0.1 g.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: the 1981 NASA(ASEE Summer Fac. Fellowship Program; 31 p
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  • 55
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    Two-phase flow and heat transfer under low gravity (1981)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: Spacelab experiment to investigate two-phase flow patterns under gravity uses a water-air mixture experiment. Air and water are circulated through the system. The quality or the mixture or air-water is controlled. Photographs of the test section are made and at the same time pressure drop across the test section is measured. The data establishes a flow regime map under reduced gravity conditions with corresponding pressure drop correlations. The test section is also equipped with an electrical resistance heater in order to allow a flow boiling experiment to be carried out using Freon II. High-speed photographs of the test section are used to determine flow patterns. The temperature gradient and pressure drop along the duct can be measured. Thus, quality change can be measured, and heat transfer calculated.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: NASA. Marshall Space Flight Center Spacecraft Dyn. as Related to Lab. Expt. in Space; p 43-57
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  • 56
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    Effects of spacecraft motions on fluids experiments (1981)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: The equations of motion governing an incompressible fluid contained in an orbiting laboratory were examined to isolate various fictitious forces and their relative influence on the fluid. The forces are divided into those arising from the orbital motions and those arising from small local motions of the spacecraft about its center of mass. The latter dominate the nonrotating experiments. Both are important for rotating experiments. A brief discussion of the onset of time-dependence and violent instability in earth-based rotating and processing systems is given.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: NASA. Marshall Space Flight Center Spacecraft Dyn. as Related to Lab. Expt. in Space; p 96-102
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  • 57
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    Convection in fluids at reduced gravity (1981)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Natural convection is not always harmful and, therefore, to be avoided. In some situations it may be desirable to have fluid flows in space processes, e.g., to stir the fluid phase for mixing and cooling or to help maintain concentration gradients. In may event, it is important to know the extent and nature of convection in space and the factors on which it depends, in order either to minimize the effects to convection, or to utilize the convection to advantage. The information needed to assess both conventional and unstable convection includes: (1) the magnitude and direction of accelerations; (2) geometric configuration; (3) imposed boundary conditions; and (4) material properties.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: NASA. Marshall Space Flight Center Spacecraft Dyn. as Related to Lab. Expt. in Space; p 69-95
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  • 58
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    Geophysical fluid dynamics (1981)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Systematic scaling or dimensional analysis reveals that certain scales of geophysical fluid flows (such as stellar, ocean, and planetary atmosphere circulations) can be accurately modeled in the laboratory using a procedure which differs from conventional engineering modeling. Rather than building a model to obtain numbers for a specific design problem, the relative effects of the significant forces are systematically varied in an attempt to deepen understanding of the effects of these forces. Topics covered include: (1) modeling a large-scale planetary atmospheric flow in a rotating cylindrical annulus; (2) achieving a radial dielectric body force; (3) spherical geophysical fluid dynamics experiments for Spacelab flights; (4) measuring flow and temperature; and (5) the possible effect of rotational or precessional disturbances on the flow in the rotating spherical containers.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Spacecraft Dyn. as Related to Lab. Expt. in Space; p 25-31
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  • 59
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    Unsteady flow in turbomachinery: An overview (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: The importance of understanding and modeling the unsteady flow phenomena in turbomachinery is discussed. Historical events in the application and development of gas turbines for aircraft propulsion are traced. Technology advancements over the years are highlighted with focus on the compression system components. Trends in compressor research within the National Advisory Committee for Aeronautics (NACA)/National Aeronautics and Space Administration (NASA) are noted. The impact of technology advancements on the increased occurrences of unsteady flow related problems in advanced engine development programs is discussed. The impact of the new and more demanding requirements being imposed on the propulsion system to meet advanced aircraft mission needs are also noted. Brief discussions on the present day understanding and modeling capability of the unsteady flow phenomena are presented to include discussions on rotating stall, surge, flutter, forced response and noise generation.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Von Karman Inst. for Fluid Dynamics Unsteady Flow in Turbomachines, Vol. 1; p 1-20
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  • 60
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    Cascade variable-conductance heat pipe (A0076) (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: The objective is to verify the capability of a cascade variable conductance heat pipe (CVCHP) system to provide precise temperature control of long life spacecraft without the need for a feedback heater or other power sources for temperature adjustment under conditions of widely varying power input and ambient environment. Solar energy is the heat source and space the heat sink for thermally loading two series connected variable conductance heat pipes. Electronics and power supply equipment requirements are minimal. A 7.5 V lithium battery supplies the power for thermistor type temperature sensors for monitoring system performance, and a 28 V lithium battery supplies power for valve actuation.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: NASA. Langley Research Center Long Duration Exposure Facility (LDEF); p 66-69
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  • 61
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    Transverse flat-plate heat pipe experiment (S1005) (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: The objective of this experiment is to evaluate the zero-g performance of a number of transverse flat plate heat pipe modules. Performance will include the transport capability of the pipes, the temperature drop, and the ability to maintain temperature over varying duty cycles and environments. Additionally, performance degradation, if any, will be monitored over the length of the Long Duration Exposure Facility (LDEF) mission. This information is necessary if heat pipes are to be considered for system designs where they offer benefits not available with other thermal control techniques.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: NASA. Langley Research Center Long Duration Exposure Facility (LDEF); p 74-77
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  • 62
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    Low-temperature heat pipe experiment package (HEPP) for LDEF (S1001) (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: The principal objectives of the experiment are to determine zero-g start-up performance for conventional and diode low temperature heat pipes, to evaluate heat pipe performance in zero-g for an extended period of time, to determine zero-g transport capability of each heat pipe, and to determine diode operation, including forward conductance, turndown ratio, and transient behavior. Two heat pipes, a fixed conductance transporter heat pipe and a thermal diode heat pipe, are coupled with a radiant cooler system. Both pipes are charged with ethane. Also integrated with the radiator is a phase change material (PCM) canister which provides temperature stability during transport tests. N-heptane, which has a melting/freezing point of 182 K, is used as the PCM. The high heat capacity (28 W-hr of latent heat) provided by the canister permits high power heat pipe testing at constant temperature.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: NASA. Langley Research Center Long Duration Exposure Facility (LDEF); p 70-73
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  • 63
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    Analysis of low-g heat transfer for a cryogenic oxygen pressurization heater (1981)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: After the external tank separates from the Orbiter about 2000 pounds of residual liquid oxygen remain in the main propulsion system lines. The pressurization of liquid oxygen from a subcritical to a supercritical state by the use of the heaters of the PRSA tanks while in a low-g environment is investigated. The performance of the heaters while bringing the state of the substance from the subcritical state to the supercritical one is studied, with particular emphasis on the time the pressurization process takes, and the temperature of the heater as the process proceeds.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Houston Univ. The 1981 NASA ASEE Summer Fac. Fellowship Program, Vol. 2; 38 p
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  • 64
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    Solution adaptive grid generation (1983)
    In:  Other Sources
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    Publication Date: 2011-08-19
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: NASA. Langley Research Center, Theoretical Aerodynamics Contractors' Workshop, Volume 2; p 651-68
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  • 65
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    Navier-Stokes solution for quasi-three dimensional flow (1983)
    In:  Other Sources
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    Publication Date: 2011-08-19
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: NASA. Langley Research Center, Theoretical Aerodynamics Contractors' Workshop, Volume 1; p 329-33
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  • 66
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    Vectorized, implicit Navier-Stokes solver for 2-D incompressible flows (1983)
    In:  Other Sources
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    Publication Date: 2011-08-19
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: NASA. Langley Research Center, Theoretical Aerodynamics Contractors' Workshop, Volume 1; p 273-31
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  • 67
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    Clebsch velocity decomposition for rotational conical flows (1983)
    In:  Other Sources
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    Publication Date: 2011-08-19
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: NASA. Langley Research Center, Theoretical Aerodynamics Contractors' Workshop, Volume 1; p 183-19
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  • 68
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    Transient thermocapillary flow in thin liquid layers (1980)
    In:  Other Sources
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    Publication Date: 2011-08-19
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Surface-Tension Gradient Induced Flows at Reduced Gravity; 24 p
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  • 69
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    Surface-tension gradient induced flows at reduced gravity, introduction (1980)
    In:  Other Sources
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    Publication Date: 2011-08-19
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Surface-Tension Gradient Induced Flows at Reduced Gravity; 21 p
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  • 70
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    Thermal convection during Bridgman crystal growth (1984)
    In:  Other Sources
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    Publication Date: 2011-08-19
    Description: Numerical experiments are used to study thermally driven flows which occur during vertical Bridgman crystal growth of a single component fluid. The solid-liquid interface was specified as parabolic and flow patterns were calculated for various insulation thicknesses, Grashof, Prandtl, and Biot numbers. When the melt is on top and the gravity vector is axially downward it is shown that flow persists as long as a radial temperature gradient is present. If the interface is convex, as viewed from the liquid, a single cell is observed. A concave interface exhibits multiple counterrotating cells. The insulation thickness and Grashof, Prandtl, and Biot numbers influence the flow in a quantitative manner.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Journal of Crystal Growth (ISSN 0022-0248); 68; 747-756
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  • 71
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    Coupled convective instabilities at crystal-melt interfaces (1984)
    In:  Other Sources
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    Publication Date: 2011-08-19
    Description: The stability of the parallel flow between a vertical crystal-melt interface and a vertical wall held at a temperature above the melting point of the crystal is analyzed for Prandtl numbers, P, ranging from 0.01 to 100. Three modes of instability occur: (1) a buoyant mode, (2) a shear mode, and (3) a coupled crystal-melt mode. The buoyant and shear modes are similar to those that occur for flow between two vertical rigid walls held at different temperatures. For Prandtl numbers greater than approximately two, the coupled crystal-melt mode occurs at a lower Grashof number than the other two modes. Specific results are given for succinonitrile (P = 22.8) and lead (P = 0.0225). These calculations and similar calculations for a cylindrical geometry were motivated by and are in general agreement with recent experiments on succinonitrile.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Journal of Crystal Growth (ISSN 0022-0248); 66; 514-524
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  • 72
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    Solidification behavior of low and high thermal conductivity materials in a Bridgman-Stockbarger furnace (1984)
    In:  Other Sources
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    Publication Date: 2011-08-19
    Description: The solid-liquid interface position and the temperature gradients in both the solid and liquid at the interface have been studied in a modified Bridgman-Stockbarger crystal growth furnace. These crystal growth factors have been studied as a function of ampoule translation rate, materials properties, and the size and temperature of a small auxiliary heater placed at the edge of the furnace hot zone. It has been found that the interface position with respect to a furnace reference point is essentially constant during a run for a low thermal conductivity material whereas the interface position changes continuously during a run with high thermal conductivity material. However, the ampoule translation rate and auxiliary heater conditions produce interface position changes in both high and low thermal conductivity materials.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Journal of Crystal Growth (ISSN 0022-0248); 69; 509-514
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  • 73
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    Influence of convection on the growth of crystals from solution (1983)
    In:  Other Sources
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    Publication Date: 2011-08-19
    Description: This is a review of the influence of convection on the growth of crystals from solution. The growth rate is increased by convection up to the point where interface kinetics becomes rate controlling. Compositional inhomogeneity and morphological instability (inclusion formation) are probably worse for gentle convection than for either no convection or for vigorous stirring. Stirring, particularly of crystal suspensions, can cause an orders of magnitude increase in the rate of formation of new crystals. This is called 'secondary nucleation'.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Journal of Crystal Growth (ISSN 0022-0248); 65; 133-142
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  • 74
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    Heat pipes in space: A NASA summary (1976)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: Experiences derived from the development, integration, and flight of NASA spacecraft and sounding rockets are presented. They include the International Heat Pipe Experiment, OAO 3, and ATS-6. Typical flight data are presented to show the performance.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: ESA Heat Pipes; p 647-653
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  • 75
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    Empirical correlations for heat transfer and flow friction characteristics of rectangular offset-fin plate-fin heat exchangers (1975)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
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  • 76
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    Inviscid interpenetration of two streams with unequal total pressures (1975)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: A theory is proposed for analyzing the inviscid interpretation of two streams in the case when the difference in total pressure between the streams is relatively small. A stream is considered which discharges from a nozzle or reservoir into a partially moving and partially stationary environment in such a way that the flows leave the solid boundaries in a tangential direction where the two streams first interact. The problem is solved by expanding in a small parameter related to the difference in total pressure between the streams, the zeroth-order solution is obtained by classical methods, and a technique similar to that employed in thin-airfoil theory is used to transfer the first-order boundary conditions to the zeroth-order boundary. A procedure is developed to transform the problem into one that can be solved by standard techniques of the theory of sectionally analytic functions. Solutions are obtained for flows with and without free streamlines, and the general theory is applied to several specific flow configurations.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Journal of Fluid Mechanics; 70; Aug. 12
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  • 77
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    Radiation exchange for a system with partially transmitting wall (1975)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: An approach is presented for applying the net radiation method developed by Siegel and Howell (1972) and Sparrow and Cess (1966) to systems involving opaque and partially transmitting walls. The results obtained from the basic equations for various values of plate emissivities and temperatures are presented in graphs. Attention is given to the window temperature relative to the temperature of the hot wall and the heat transferred relative to that transferred without the window.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Letters in Heat and Mass Transfer; 2; Mar
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  • 78
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    Derivation and application of the reciprocity relations for radiative transfer with internal illumination (1975)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: A Green's function formulation is used to derive basic reciprocity relations for planar radiative transfer in a general medium with internal illumination. Reciprocity (or functional symmetry) allows an explicit and generalized development of the equivalence between source and probability functions. Assuming similar symmetry in three-dimensional space, a general relationship is derived between planar-source intensity and point-source total directional energy. These quantities are expressed in terms of standard (universal) functions associated with the planar medium, while all results are derived from the differential equation of radiative transfer.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Journal of Quantitative Spectroscopy and Radiative Transfer; 15; Sept
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  • 79
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    Radiation from an array of longitudinal fins of triangular profile (1975)
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    Publication Date: 2011-08-16
    Description: Radiation from an array of longitudinal fins of triangular profile is analyzed, including fin-to-fin and fin-to-base interactions. The effect of base cylinder radiation and the fin-base radiative interaction is found to be significant for fin width/tube radius ratios less than 8. Results presented may be used to optimize the design of a fin array with respect to weight.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: AIAA Journal; 13; May 1975
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  • 80
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    Comment on 'subsonic and supersonic boundary-layer flow past a wavy wall' (1975)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: AIAA Journal; 13; Apr. 197
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  • 81
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    Characteristics of the unsteady motion on transversely sheared mean flows (1978)
    In:  Other Sources
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    Publication Date: 2011-08-17
    Description: An explicit representation for the unsteady motion on a transversely sheared mean flow is obtained which corresponds to the gustline motion on a uniform mean flow. The important features of this motion are discussed. It is shown that its velocity, pressure and vorticity are all induced by a certain disturbance field that is a linear combination of the vorticity and particle-displacement fields and is everywhere frozen in the mean flow. The general ideas are illustrated by considering the scattering of a gust by a half-plane embedded in a shear flow.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Journal of Fluid Mechanics; 84; Jan. 30
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  • 82
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    Periodic motion of two and four vortices in a cylindrical pipe (1984)
    In:  Other Sources
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    Publication Date: 2011-08-18
    Description: The motion of two and four rectilinear vortices inside a cylindrical pipe is studied under the restriction that the total circulation be zero. In the two-vortex case, it is shown that the motion is always periodic and an expression for the period is derived. In the four-vortex case, the motion is determined not to be periodic in general. However, a class of solutions where the motion is periodic is found. Several sample calculations of the vortex motion are included.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Physics of Fluids (ISSN 0031-9171); 27; 1583-158
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  • 83
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    Turbulent solutions of the equations of fluid motion (1984)
    In:  Other Sources
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    Publication Date: 2011-08-18
    Description: Some turbulent solutions of the unaveraged Navier-Stokes equations (equations of fluid motion) are reviewed. Those equations are solved numerically in order to study the nonlinear physics of incompressible turbulent flow. Initial three-dimensional cosine velocity fluctuations and periodic boundary conditions are used in most of the work considered. The three components of the mean-square velocity fluctuations are initially equal for the conditions chosen. The resulting solutions show characteristics of turbulence such as the linear and nonlinear excitation of small-scale fluctuations. For the stronger fluctuations, the initially nonrandom flow develops into an apparently random turbulence. Thus randomness or turbulence can arise as a consequence of the structure of the Navier-Stokes equations. The cases considered include turbulence which is statistically homogeneous or inhomogeneous and isotropic or anisotropic. A mean shear is present in some cases. A statistically steady-state turbulence is obtained by using a spatially periodic body force. Various turbulence processes, including the transfer of energy between eddy sizes and between directional components, and the production, dissipation, and spatial diffusion of turbulence, are considered. It is concluded that the physical processes occurring in turbulence can be profitably studied numerically.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Reviews of Modern Physics (ISSN 0034-6861); 56; 223-254
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  • 84
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    Effect of location in an array on heat transfer to a short cylinder in crossflow (1984)
    In:  Other Sources
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    Publication Date: 2011-08-18
    Description: An experiment was conducted to measure the heat transfer from a heated cylinder in crossflow in an array of circular cylinders. All cylinders had a length-to-diameter ratio of 3.0. Both in-line and staggered array patterns were studied. The cylinders were spaced 2.67 diameters apart center-to-center in both the axial and transverse directions to the flow. The row containing the heated cylinder remained in a fixed position in the channel and the relative location of this row within the array was changed by adding up to five upstream rows. The working fluid was nitrogen gas at pressures from 100 to 600 kPa. The Reynolds number range based on cylinder diameter and average unobstructed channel velocity was from 5,000 to 125,000. Turbulence intensity profiles were measured for each case at a point one half space upstream of the row containing the heated cylinder. The basis of comparison for all the heat transfer data was the single row with the heated cylinder. For the in-line cases the addition of a single row of cylinders upstream of the row containing the heated cylinder increased the heat transfer by an average of 50 percent above the base case. Adding up to five more rows caused no increase or decrease in heat transfer. Adding rows in the staggered array cases resulted in average increases in heat transfer of 21, 64, 58, 46, and 46 percent for one to five upstream rows, respectively. Previously announced in STAR as N82-19493
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: ASME, Transactions, Journal of Heat Transfer (ISSN 0022-1481); 106; 42-48
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    The production of turbulent stress in a shear flow by irrotational fluctuations (1983)
    In:  Other Sources
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    Publication Date: 2011-08-18
    Description: Attention is given to the way in which external turbulence affects an initially turbulence-free region in which there is a mean velocity gradient. External turbulence induces irrotational fluctuations in the sheared region which interact with the shear to produce rotational velocity fluctuations and mean Reynolds stresses. Since the actual front between the initial external turbulence and the shear flow is a randomly contorted surface, the turbulence near the front is intermittent, and is presently included in the form of a simple statistical model. In wind tunnel tests, turbulent shear stress was found to grow from zero to significant values in the interaction region. Observed stress magnitude and extent agrees with predictions, and it is concluded that turbulent stresses can be produced by irrotational fluctuations in a region of mean shear.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Journal of Fluid Mechanics (ISSN 0022-1120); 137; 307-329
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    Viscous thermocapillary convection at high Marangoni number (1983)
    In:  Other Sources
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    Publication Date: 2011-08-18
    Description: A liquid, contained in a quarter plane, undergoes steady motion due to thermocapillary forcing on its upper boundary, a free surface separating the liquid from a passive gas. The rigid vertical sidewall has a strip whose temperature is elevated compared with the liquid at infinity. A boudnary-layer analysis is performed that is valid for large Marangoni numbers M and Prandtl numbers P. It is found that the Nusselt number N for the horizontal heat transport satisfies N proportional to min (M to the 1 2/7/power, M to the 1 1/5/power, M to the 1 1/10/power) Generalizations are discussed.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Journal of Fluid Mechanics (ISSN 0022-1120); 135; 175-188
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    Stagnation-point ablation of carbonaceous flat disks. II Experiment (1983)
    In:  Other Sources
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    Publication Date: 2011-08-18
    Description: Six flat-disk models made of carbon-carbon and carbon-phenolic materials were launched in an argon-filled track-range facility to test ablation characteristics in a radiation-dominated, massive-blowing environment. The shock standoff distances deduced from the shadowgraphs agree with theoretical predictions during the earlier portion of the flight, while the wall temperatures determined by the image-converter photographs agree with predictions during the later portion. The measured surface recessions exceed the calculated values by about 60 percent for carbon-phenolic and 30 percent for carbon-carbon. The discrepancies are attributed to spallation. The measured char thicknesses agree with theoretical predictions.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: AIAA Journal (ISSN 0001-1452); 21; 1748-175
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  • 88
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    Continuation in a parameter - Experience with viscous and free surface flows (1983)
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    Publication Date: 2011-08-18
    Description: The results of modifications in continuation methods applied to obtain solutions to the Navier-Stokes systems of equations for incompressible, two-dimensional, steady flows are reported. It is shown that parameter continuation permits prediction of accurate, initial estimates for iterative processing of nonlinear finite difference and finite element equations of motions. The new parameter steps are derived from values of the preceding parameter steps. The accuracy of the estimates is ensured with appropriate choices of the step size. The continuation predictor/iterative corrector is demonstrated to trace the branches of parameter space along which steady flow states are found, and techniques are available for tracing multiply branching paths. The techniques are applied to solving the Navier-Stokes equations for flow through a rotating square channel, the formation of a falling liquid curtain, and gyrostatic equilibria of rotating cylindrical drops.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
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    Modeling of transient two-component flow using a four-point implicit method (1983)
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    Publication Date: 2011-08-18
    Description: The four-point, centered implicit scheme that is extensively used in open channel flow simulation is shown to be applicable to rapid and slow pressure transient problems in conduits with nearly single phase and two-phase flows. It is only necessary to choose the proper weighting factor value, theta, of the Courant number. For rapid pressure transients such as waterhammer, the implicit method can yield reasonable results with limited numerical dispersion and attenuation if theta is only slightly greater than the critical value of 0.5. For slower pressure gradients in single and two-phase flows, reasonable numerical solutions may be achieved for Courant number values as high as 20.
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    The production of turbulent stress in a shear flow by irrotational fluctuations (1983)
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    Publication Date: 2011-08-18
    Description: This paper examines, both theoretically and experimentally, the effect produced by irrotational fluctuations, associated with a nearby turbulent field, in a region where the turbulence is initially very low but where there is a mean shear. Calculations are based on rapid distortion theory and experiments use linearized hot wire anemometers in an open circuit wind tunnel. Turbulent shear stress is observed to grow from zero to significant values in the interaction region. The magnitude and extent of this observed shear stress agree reasonably well with predictions of the analysis, when intermittency effects are included. It is concluded that turbulent stresses can be produced by irrotational fluctuations in a region of mean shear and that this effect can be estimated using rapid distortion theory if the overall strain ratio is not large.
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    A modified Dodge algorithm for the parabolized Navier-Stokes equations and compressible duct flows (1983)
    In:  Other Sources
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    Publication Date: 2011-08-18
    Description: A revised version of Dodge's split-velocity method for numerical calculation of compressible duct flow was developed. The revision incorporates balancing of mass flow rates on each marching step in order to maintain front-to-back continuity during the calculation. The (checkerboard) zebra algorithm is applied to solution of the three dimensional continuity equation in conservative form. A second-order A-stable linear multistep method is employed in effecting a marching solution of the parabolized momentum equations. A checkerboard iteration is used to solve the resulting implicit nonlinear systems of finite-difference equations which govern stepwise transition. Qualitative agreement with analytical predictions and experimental results was obtained for some flows with well-known solutions. Previously announced in STAR as N82-16363
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: International Journal for Numerical Methods in Fluids (ISSN 0271-2091); 3; 493-506
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  • 92
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    Wall mass transfer and pressure gradient effects on turbulent skin friction (1984)
    In:  Other Sources
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    Publication Date: 2011-08-18
    Description: The effects of mass injection and pressure gradients on the drag of surfaces were studied theoretically with the aid of boundary-layer and Navier-Stokes codes. The present investigation is concerned with the effects of spatially varying the injection in the case of flat-plate drag. Effects of suction and injection on wavy wall surfaces are also explored. Calculations were performed for 1.2 m long surfaces, one flat and the other sinusoidal with a wavelength of 30.5 cm. Attention is given to the study of the effect of various spatial blowing variations on flat-plate skin friction reduction, local skin friction coefficient calculated by finite difference boundary-layer code and Navier-Stokes code, and the effect of phase-shifting sinusoidal mass transfer on the drag of a sinusoidal surface.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: AIAA Journal (ISSN 0001-1452); 22; 143-145
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  • 93
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    Accuracy of approximations to the Navier-Stokes equations (1983)
    In:  Other Sources
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    Publication Date: 2011-08-18
    Description: The systems of truncated differential equations that have been proposed to reduce the complexity and large computational costs of solutions to the full Navier-Stokes equations are considered. These systems are computationally efficient and capture all the physically relevant behavior. The systems follow a certain hierarchy: (1) the classical boundary-layer equations with specified edge properties (usually the streamwise pressure distribution); (2) the coupled boundary-layer/inviscid equations; (3) the so-called thin-layer equations that discard streamwise diffusion; and (4) the Navier-Stokes equations. Consideration is given to each of these approximations applied to an incompressible, laminar-separating flow at low and moderate Reynolds numbers. It is pointed out that for any flow or region of flow for which viscous-inviscid interaction effects are small, classical boundary-layer equations will provide a satisfactory description of the viscous flow at a fraction of the computational cost of any higher approximations.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: AIAA Journal (ISSN 0001-1452); 21; 1759
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  • 94
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    Numerical aspects of unsteady flow calculations (1984)
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    Publication Date: 2011-08-18
    Description: The numerical aspects of simulation unsteady flows which arise in turbomachinery are addressed. In particular the simulation of rotating stall and surge is discussed.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Von Karman Inst. for Fluid Dynamics Unsteady Flow in Turbomachines, Vol. 2; 75 p
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  • 95
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    Growth of Goertler vortices in compressible boundary layers along curved surfaces (1983)
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    Publication Date: 2011-08-19
    Description: An investigation of the growth of the three-dimensional, counter-rotating, longitudinal type vortices is considered in two-dimensional laminar compressible boundary-layer flow. The basic approximation of the disturbance equations that includes the terms due to boundary layer growth is considered and solved numerically. These terms are shown to have large local effects near the neutral stability region. The study shows that the instability of the boundary layer with respect to the three-dimensional vortices sets in at higher Goertler number as Mach number increases. Also the maximum amplitude ratio of the vortices is reduced by about 20 percent as Mach number increases from 0 to 5.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Journal of Engineering and Applied Sciences (ISSN 0191-9539); 2; 3, 19; 213-238
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  • 96
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    Numerical algorithm conjugating steady and transient, separated, compressible flow and a solid body having arbitrarily distributed heat sources (1984)
    In:  Other Sources
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    Publication Date: 2011-08-19
    Description: A numerical algorithm that is second-order accurate in time has been developed for the conjugated problem of a separated, compressible flow field and a conductive solid body. The full two-dimensional time-dependent Navier-Stokes equations are coupled with the time-dependent energy equation for the solid body and are solved simultaneously. using implicit algorithms. The energy equation for the solid body may include arbitrarily distributed heat sources. The algorithm has been exmined for the case of two-dimensional supersonic compression-corner interaction, with a heat source embedded in the wall in the vicinity of the separation bubble and the attached boundary layer. The effect of the heat source on the flow field is studied for steady and transient cases.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Numerical Heat Transfer (ISSN 0149-5720); 7; 395-411
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  • 97
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    A unified relation for cavitation erosion (1984)
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    Publication Date: 2011-08-19
    Description: A power-law relationship between the average erosion rate and cumulative erosion is presented. Data analyses from Venturi, magnetostriction, and liquid-impingement devices conform to this unified relation. A normalization technique is also suggested for prediction purposes.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: International Journal of Mechanical Sciences (ISSN 0020-7403); 26; 5, 19
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  • 98
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    Laminar flow effects in the coil planet centrifuge (1984)
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    Publication Date: 2011-08-19
    Description: The coil planet centrifuge designed by Ito employs flow of a single liquid phase, through a rotating coiled tube in a centrifugal force field, to provide a separation of particles based on sedimentation rates. Mathematical solutions are derived for the linear differential equations governing particle behavior in the coil planet centrifuge device. These solutions are then applied as the basis of a model for optimizing particle separations.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Journal of Chromatography (ISSN 0021-9673); 295; 1-11
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  • 99
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    A review of turbulent-boundary-layer heat transfer research at Stanford, 1958-1983 (1984)
    In:  Other Sources
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    Publication Date: 2011-08-19
    Description: For the past 25 years, there has existed in the Thermosciences Laboratory of the Mechanical Engineering Department of Stanford University a research program, primarily experimental, concerned with heat transfer through turbulent boundary layers. In the early phases of the program, the topics considered were the simple zero-pressure-gradient turbulent boundary layer with constant and with varying surface temperature, and the accelerated boundary layer. Later equilibrium boundary layers were considered along with factors affecting the boundary layer, taking into account transpired flows, flows with axial pressure gradients, transpiration, acceleration, deceleration, roughness, full-coverage film cooling, surface curvature, free convection, and mixed convection. A description is provided of the apparatus and techniques used, giving attention to the smooth plate rig, the rough plate rig, the full-coverage film cooling rig, the curvature rig, the concave wall rig, the mixed convection tunnel, and aspects of data reduction and uncertainty analysis.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
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  • 100
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    Turbulent roughness drag due to surface waviness at low roughness Reynolds numbers (1984)
    In:  Other Sources
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    Publication Date: 2011-08-19
    Description: The current investigation has the objective to provide data which will make it possible to obtain a better estimate regarding the roughness drag for surface waviness. The data employed for this investigation were acquired in connection with a wavy wall study which was conducted as part of an overall program to reduce the skin friction of turbulent boundary layers in external flows. The results of the present investigation show that the low-speed roughness drag of small-amplitude sinusoidal wave trains having wavelengths of the order of the boundary-layer thickness is not only a function of h/lambda (h = total wave height, lambda = wavelength), but, in addition, is also a function of the roughness Reynolds number.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Journal of Aircraft (ISSN 0021-8669); 21; 978
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