Publication Date:
1984-06-15
Description:
A new class of synthetic antifungal agents, the allylamines , has been developed by modification of naftifine , a topical antimycotic. SF 86-327, the most effective of these compounds so far, is highly active in vitro against a wide range of fungi and exceeds clinical standards in the oral and topical treatment of guinea pig dermatophytoses. SF 86-327 is a powerful specific inhibitor of fungal squalene epoxidase, a key enzyme in sterol biosynthesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petranyi, G -- Ryder, N S -- Stutz, A -- New York, N.Y. -- Science. 1984 Jun 15;224(4654):1239-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6547247" target="_blank"〉PubMed〈/a〉
Keywords:
Allylamine/analogs & derivatives/*chemical synthesis/pharmacology
;
Amines/*chemical synthesis
;
Animals
;
Antifungal Agents/*chemical synthesis/pharmacology
;
Chemical Phenomena
;
Chemistry
;
Dermatomycoses/drug therapy
;
Fungi/*drug effects/enzymology
;
Guinea Pigs
;
Naphthalenes/chemical synthesis/pharmacology
;
Oxygenases/*antagonists & inhibitors
;
Squalene Monooxygenase
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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