Publication Date:
1983-04-15
Description:
Alkylating agents that display strong selectivity for opiate receptor types delta or mu were prepared by appropriate modification of the structures of the strong analgesics fentanyl, etonitazene, and endoethenotetrahydrooripavine. The availability of these substances should facilitate studies of the structural basis of receptor specificity and of the physiologic roles of these receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rice, K C -- Jacobson, A E -- Burke, T R Jr -- Bajwa, B S -- Streaty, R A -- Klee, W A -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):314-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6132444" target="_blank"〉PubMed〈/a〉
Keywords:
Alkylation
;
Animals
;
Benzimidazoles/analogs & derivatives/metabolism
;
Brain/physiology
;
Cells, Cultured
;
Chemical Phenomena
;
Chemistry
;
Enkephalin, Methionine/analogs & derivatives/metabolism
;
Fentanyl/analogs & derivatives/metabolism
;
*Isothiocyanates
;
Ligands
;
Rats
;
Receptors, Opioid/*metabolism/physiology
;
Thebaine/analogs & derivatives/pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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