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  • Male  (241)
  • Female  (231)
  • Cats  (37)
  • American Association for the Advancement of Science (AAAS)  (395)
  • American Association of Petroleum Geologists (AAPG)
  • Nature Publishing Group
  • 1975-1979  (395)
  • 1940-1944
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Keywords
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  • American Association for the Advancement of Science (AAAS)  (395)
  • American Association of Petroleum Geologists (AAPG)
  • Nature Publishing Group
  • Springer  (2)
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  • 1
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    Regional localization of the gene for human phosphoribosylpyrophosphate synthetase on the X chromosome (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-09
    Description: Sixty-eight independent hybrid clones were isolated after irradiated normal human lymphocytes were fused with Chinese hamster fibroblasts lacking hypoxanthine-guanine phosphoribosyltransferase activity. The cells were grown under selective conditions requiring retention of the X chromosome-linked locus for human hypoxanthine-guanine phosphoribosyltransferase. The frequency and patterns of cotransference of human phosphoribosylpyrophosphate synthetase with the selected marker and with additional X-linked enzymatic markers confirm X linkage of the structural gene for human phosphoribosylpyrophosphate synthetase and support assignment of this gene to a position on the long arm of the X, between the loci for alpha-galactosidase and hypoxanthine-guanine phosphoribosyltransferase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Becker, M A -- Yen, R C -- Itkin, P -- Goss, S J -- Seegmiller, J E -- Bakay, B -- New York, N.Y. -- Science. 1979 Mar 9;203(4384):1016-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/218284" target="_blank"〉PubMed〈/a〉
    Keywords: Chromosome Mapping ; Female ; Genetic Linkage ; Humans ; Hybrid Cells ; Hypoxanthine Phosphoribosyltransferase/genetics ; Phosphotransferases/*genetics ; Ribose-Phosphate Pyrophosphokinase/*genetics ; *Sex Chromosomes ; *X Chromosome
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Pituitary-brain vascular relations: a new paradigm (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-06
    Description: Vascular casts of the pituitary gland have demonstrated a paucity of veins extending from the adenohypophysis to the systemic circulation and have suggested that some adenohypophyseal venous blood returns to the neurohypophysis. The neurohypophyseal capillary bed may function as a vascular switch and in this article a series of 14 questions are proposed regarding the vascular dynamics of the pituitary. Together these questions raise the larger question, namely, whether pituitary hormones are transported directly to the brain to modify brain function?〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bergland, R M -- Page, R B -- New York, N.Y. -- Science. 1979 Apr 6;204(4388):18-24.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/373118" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arteriovenous Anastomosis/anatomy & histology ; Capillaries/anatomy & histology ; Cats ; *Cerebrovascular Circulation ; Dogs ; Humans ; Hypothalamo-Hypophyseal System/blood supply ; Pituitary Gland/*blood supply ; Pituitary Gland, Anterior/blood supply ; Rats ; Species Specificity
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Opioid peptides modulate luteinizing hormone secretion during sexual maturation (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-16
    Description: Subcutaneous injections of naloxone, an opiate antagonist, lead to an increase in serum luteinizing hormone concentrations in female but not in male rats before they reach puberty. In addition, estradiol benzoate specifically blocks the luteinizing hormone response to naloxone in prepubertal female rats, suggesting that the opioid peptides have a physiological role in the endocrine events leading to sexual maturation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blank, M S -- Panerai, A E -- Friesen, H G -- New York, N.Y. -- Science. 1979 Mar 16;203(4385):1129-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424743" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Endorphins/antagonists & inhibitors/*physiology ; Estradiol/pharmacology ; Female ; Luteinizing Hormone/blood/*secretion ; Male ; Naloxone/antagonists & inhibitors/pharmacology ; Rats ; Secretory Rate/drug effects ; Sexual Maturation/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Metabolism of americium-241 in man: an unusual case of internal contamination of a child and his father (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-05
    Description: The metabolism of americium-241 has been studied during an 8-year period in an adult male and his son who, at the ages of 50 and 4 years, respectively, were accidentally and unknowingly contaminated within their home by means of inhalation. Chelation therapy with calcium trisodium pentetate was more effective in enhancing the removal of americium-241 from the child than from the father.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, N -- Sasso, T L -- Wrenn, M E -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):64-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482925" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Americium/*metabolism/poisoning ; Body Burden ; Body Height ; Body Weight ; Bone and Bones/metabolism ; Chelating Agents/*therapeutic use ; Child, Preschool ; Humans ; Liver/metabolism ; Lung/metabolism ; Male ; Middle Aged
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Ingested mineral fibers: elimination in human urine (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-13
    Description: Sediment in human urine examined by transmission electron microscopy contains amphibole fibers which originate from the ingestion of drinking water contaminated with these mineral fibers. The ingestion of filtered water results in the eventual disappearance of amphibole fibers from urine. These observations provide the first direct evidence for the passage of mineral fibers through the human gastro-intestinal mucosa under normal conditions of the alimentary canal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cook, P M -- Olson, G F -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):195-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/219478" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Female ; Gastric Mucosa/metabolism ; Humans ; Intestinal Absorption ; Intestinal Mucosa/metabolism ; Male ; Middle Aged ; Silicon Dioxide/metabolism/*urine ; *Water Pollutants ; *Water Pollutants, Chemical
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Preferential transmission of the Z deficient allele of alpha 1-antitrypsin (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-27
    Description: The transmission of the Z deficient allele of alpha 1-antitrypsin was studied in 23 families, each with a single parent heterozygous for this allele. When the mother carried the Z allele, the distribution of phenotypes in the children did not differ significantly from the expected frequency. In contrast, when the father was the carrier, a significant increase of heterozygous phenotypes was observed in the children. This observation suggests that a selective advantage is associated with the expression of the Z allele in male gametes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chapuis-Cellier, C -- Arnaud, P -- New York, N.Y. -- Science. 1979 Jul 27;205(4404):407-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/313077" target="_blank"〉PubMed〈/a〉
    Keywords: *Alleles ; Child ; Female ; Heterozygote Detection ; Humans ; Male ; *Polymorphism, Genetic ; Sex Factors ; alpha 1-Antitrypsin/genetics ; *alpha 1-Antitrypsin Deficiency
    Print ISSN: 0036-8075
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  • 7
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    Visual resolution and receptive field size: examination of two kinds of cat retinal ganglion cell (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-07
    Description: Intraocular recordings from brisk-sustained and brisk-transient ganglion cells in the cat's retina revealed a systematic increase in center size and decrease in spatial cut-off frequency with increasing distance from the area centralis. At any one eccentricity sizes of the centers of sustained and transient cells did not overlap, and the variation in cut-off frequency for each class was constrained to about one-half octave.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cleland, B G -- Harding, T H -- Tulunay-Keesey, U -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1015-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472720" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Evoked Potentials ; Ganglia/physiology ; Retina/cytology/*physiology ; Vision, Ocular/*physiology ; *Visual Fields
    Print ISSN: 0036-8075
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  • 8
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    Transfer of experimental allergic encephalomyelitis with guinea pig peritoneal exudate cells (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-09
    Description: Incubation with specific antigen, myelin basic protein, greatly enhances the ability of guinea pig peritoneal exudate cells to transfer experimental allergic encephalomyelitis. Reproducibly successful transfers are obtained with 10(7) cells. With this relatively small number of cells, in vitro studies to determine the immunologic mechanisms involved in the disease process are now possible.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Driscoll, B F -- Kies, M W -- Alvord, E C Jr -- New York, N.Y. -- Science. 1979 Feb 9;203(4380):547-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/83676" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens ; Ascitic Fluid/*cytology/immunology ; Cell Adhesion ; Cell Division ; Encephalomyelitis, Autoimmune, Experimental/immunology/*transmission ; Exudates and Transudates/immunology ; Guinea Pigs ; Immunization, Passive ; Male ; Myelin Basic Protein/immunology
    Print ISSN: 0036-8075
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  • 9
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    Baroreceptor activation reduces reactivity to noxious stimulation: implications for hypertension (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-21
    Description: The hypothesis was tested that an acute rise of blood pressure may reduce reactivity to noxious stimuli through a baroreceptor-mediated reduction of cerebral arousal. When blood pressure was raised by an infusion of phenylephrine, rats showed less running to terminate or avoid noxious stimuli than during saline infusions. This effect was not seen in rats with denervated baroreceptors. The results suggest that a rise of blood pressure could have motivational consequences significant for human hypertension.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dworkin, B R -- Filewich, R J -- Miller, N E -- Craigmyle, N -- Pickering, T G -- New York, N.Y. -- Science. 1979 Sep 21;205(4412):1299-301.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472749" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Avoidance Learning/drug effects/*physiology ; Blood Pressure/drug effects ; Heart Rate/drug effects ; Hypertension/*physiopathology ; Male ; Motivation/physiology ; Phenylephrine/pharmacology ; Pressoreceptors/*physiology ; Rats
    Print ISSN: 0036-8075
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  • 10
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    Hormone changes triggered by aggression in a natural population of blackbirds (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-02
    Description: The concentrations of hormones in the plasma of male red-winged blackbirds caught at the height of an aggressive encounter are significantly different from those in males that have not recently engaged in aggressive behavior. Concentrations of luteinizing hormone in the plasma are decreased in the aggressive males, whereas androgen concentrations are affected in a more complex manner. Concentrations of corticoids do not appear to be affected by aggressive behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harding, C F -- Follett, B K -- New York, N.Y. -- Science. 1979 Mar 2;203(4383):918-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/570304" target="_blank"〉PubMed〈/a〉
    Keywords: Aggression/*physiology ; Animals ; Animals, Wild ; Birds/*physiology ; Corticosterone/blood ; Dihydrotestosterone/blood ; Hormones/*blood ; Humans ; Luteinizing Hormone/blood ; Male ; Testosterone/blood
    Print ISSN: 0036-8075
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  • 11
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    Cerebral specialization, writing posture, and motor control of writing in left-handers (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-21
    Description: It has been suggested that the inverted hand position of left-handers during writing indicates the left hemisphere of their brain is linguistically specialized and that the writing of these left-handers may be controlled via ipsilateral pathways. Electroencephalograph alpha asymmetry measures at central and parietal leads, as well as dichotic tests, differentiated right-handers from left-handers, but not inverters from noninverters. Electroencephalograph differences between hand posture groups did appear, but only at occipital leads during reading and writing tasks. Regardless of hand posture or speech lateralization, the right central region of the brain is significantly involved in the control of left-handed writing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Herron, J -- Galin, D -- Johnstone, J -- Ornstein, R E -- New York, N.Y. -- Science. 1979 Sep 21;205(4412):1285-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472745" target="_blank"〉PubMed〈/a〉
    Keywords: Auditory Perception/physiology ; Brain/*physiology ; Cognition/physiology ; Female ; *Functional Laterality ; Humans ; Male ; Movement ; *Posture ; Speech/physiology ; Visual Perception/physiology ; *Writing
    Print ISSN: 0036-8075
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  • 12
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    Chromosome 13 long arm interstitial deletion may result from maternal inverted insertion (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hoegerman, S F -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1035-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472726" target="_blank"〉PubMed〈/a〉
    Keywords: Chromosome Aberrations/*genetics ; Chromosome Deletion ; Chromosome Disorders ; Chromosome Inversion ; *Chromosomes, Human, 13-15 ; Female ; Humans
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 13
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    Vomeronasal and olfactory system modulation of maternal behavior in the rat (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-26
    Description: The onset of maternal responsiveness by virgin female rats to foster pups was observed after (i) complete vomeronasal nerve cuts, (ii) partial olfactory bulb cuts, or (iii) the combined procedures. Although both vomeronasal nerve cuts and olfactory bulb cuts resulted in a more rapid onset of maternal care, relative to control animals with sham operations, animals sustaining the loss of both sources of olfactory input exhibited the shortest response latency. These findings are discussed in terms of the probable distinct functions of the two olfactory systems in the control of maternal behavior in the rat.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fleming, A -- Vaccarino, F -- Tambosso, L -- Chee, P -- New York, N.Y. -- Science. 1979 Jan 26;203(4378):372-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760196" target="_blank"〉PubMed〈/a〉
    Keywords: Afferent Pathways ; Animals ; Central Nervous System/*physiology ; Female ; *Maternal Behavior ; Olfactory Bulb/physiology ; Olfactory Pathways/*physiology ; Rats ; Smell/*physiology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    Structure of physiologically identified X and Y cells in the cat's lateral geniculate nucleus (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-08
    Description: Horseradish peroxidase injected into 18 single, physiologically identified geniculate X and Y cells permitted a detailed morphological correlate to be determined for the physiological properties of each neuron. Class 1 morphological characteristics were associated with Y cells, class 3 with X cells, and class 2 structural traits were seen in both physiological types.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Friedlander, M J -- Lin, C S -- Sherman, S M -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1114-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451559" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Geniculate Bodies/*cytology/physiology ; Horseradish Peroxidase ; Interneurons/cytology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 15
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    Difference between postpartum and nutritional amenorrhea (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frisch, R E -- McArthur, J W -- New York, N.Y. -- Science. 1979 Mar 2;203(4383):921-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/419411" target="_blank"〉PubMed〈/a〉
    Keywords: Amenorrhea/*etiology/physiopathology ; Body Weight ; Female ; Humans ; Lactation ; Nutrition Disorders/complications ; Pregnancy ; Time Factors
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  • 16
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    Cortical plasticity in monocularly deprived immobilized kittens depends on eye movement (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: A marked reduction of binocular cells in striate cortex is found if 4-week-old kittens are visually stimulated monocularly while anesthetized and held in a stereotaxic apparatus. If the kittens are paralyzed and artificially respirated, changes are not found unless an eye is moved mechanically. It appears that eye movement and visual stimulation are necessary conditions for deactivation of binocular connections, but neither is sufficient to induce such changes alone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Freeman, R D -- Bonds, A B -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1093-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493996" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Evoked Potentials ; *Eye Movements ; Functional Laterality ; Immobilization ; Paralysis/physiopathology ; Visual Cortex/*growth & development/physiology ; Visual Pathways/*growth & development
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  • 17
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    Development of the capacity for tactile information transfer between hemispheres in normal children (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-22
    Description: The hypothesis of less direct interaction between hemispheres in young children was supported by a behavioral test. Fabric samples were compared with either the same hand (same hemisphere) or with opposite hands (between hemispheres). Crossed errors were a significantly larger proportion of total errors in 3-year-olds than in 5-year-olds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Galin, D -- Johnstone, J -- Nakell, L -- Herron, J -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1330-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451542" target="_blank"〉PubMed〈/a〉
    Keywords: Brain/*growth & development/physiology ; Child, Preschool ; Female ; *Functional Laterality ; Humans ; Touch/*physiology
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  • 18
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    Induction of copulatory behavior in sexually inactive rats by naloxine (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-13
    Description: The intraventricular injection of D-alanine-methionine-enkephalinamide (D-Ala2-Met-enkephalinamide), a synthetic analog of Met-enkephalin that is resistant to enzymatic degradation, inhibits copulatory behavior in sexually vigorous male rats in doses which do not influence motor activity or feeding behavior. This effect is prevented by naloxone, a specific inhibitor of opioid receptors. In addition, injections of naloxone induce copulatory behavior in sexually inactive male rats. These results suggest that endorphins play an important role in the regulation of sexual behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gessa, G L -- Paglietti, E -- Quarantotti, B P -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):203-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432642" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Copulation/*drug effects ; Endorphins/*pharmacology ; Enkephalins/*pharmacology ; Feeding Behavior/drug effects ; Male ; Motor Activity/drug effects ; Naloxone/*pharmacology ; Rats
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Vascular smooth muscle cell kinetics: a new assay for studying patterns of cellular proliferation in vivo (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-31
    Description: A new quantitative assay for studying the kinetics of vascular smooth muscle cells in vivo is reported. The assay was used to determine the specific activity of DNA from rabbit aortic smooth muscle cells stimulated to grow by removal of the endothelial layer. The specific activity of the DNA was correlated with the rate of tritiated thymidine incorporation as measured by autoradiography and with the rate of DNA synthesis as estimated by direct measurement of cellular proliferation. Smooth muscle cells exhibit a 24-hour latent period in vivo prior to DNA synthesis; the synthesis peaks at 48 hours and then rapidly declines. The decline in DNA synthesis is not related to endothelial regrowth, and may be of homeostatic significance in limiting luminal stenosis. The assay offers a rapid and reliable alternative to autoradiographic and morphometric techniques for evaluating growth kinetics and growth regulation in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldberg, I D -- Stemerman, M B -- Schnipper, L E -- Ransil, B J -- Crooks, G W -- Fuhro, R L -- New York, N.Y. -- Science. 1979 Aug 31;205(4409):920-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472713" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aorta/*cytology ; Arteriosclerosis/metabolism/pathology ; Cell Division ; DNA/biosynthesis ; Endothelium/cytology ; Male ; Muscle, Smooth/*cytology/metabolism ; Rabbits
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    Muscle fiber regeneration after transplantation: prediction of structure and physiology from electromyograms (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-08
    Description: Digitized electromyographic activity of transplanted extensor digitorum longus (EDL) muscles in cats differs from that of control EDL and anterior tibialis muscles lying adjacent to transplanted EDL muscles. In autotransplanted muscles, the cross-sectional area of the fibers shows a negative correlation with mean spike frequency and a positive correlation with mean amplitude. The mean frequency-amplitude products correlate with isometric tetanic tensions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gorniak, G C -- Gans, C -- Faulkner, J A -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1085-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451552" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Cats ; Electrodes ; Electromyography/methods ; Muscles/cytology/physiology/*transplantation ; *Regeneration ; Transplantation, Autologous
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  • 21
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    Electroencephalogram correlates of higher cortical functions (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-02-16
    Description: By means of two-stage, nonlinear multivariate pattern recognition, electroencephalograms (EEG's) were analyzed during performance of verbal and spatial tasks. Complex scalp distributions of theta-, beta-, and, to a lesser extent, alpha-band spectral intensities discriminated between the two members of a pair of tasks, such as writing sentences and Koh's block design. Small EEG asymmetries were probably attributable to limb movements and other uncontrolled noncognitive aspects of tasks. Significant EEG differences beteeen cognitive tasks were eliminated when controls for inter-task differences in efferent activity, stimulus characteristics, and performance-related factors were introduced. Each controlled task was associated with an approximately 10 percent reduction, as compared with visual fixation, in the magnitude of alpha- and beta-band spectral intensity. This effect occurred bilaterally and was approximately the same over occipital, parietal, and central regions, with some minor difference over the frontal region in the beta band. With these controls, no evidence for lateralization of different cognitive functions was found in the EEG.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gevins, A S -- Zeitlin, G M -- Doyle, J C -- Yingling, C D -- Schaffer, R E -- Callaway, E -- Yeager, C L -- New York, N.Y. -- Science. 1979 Feb 16;203(4381):665-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760212" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Cerebral Cortex/*physiology ; Cognition/*physiology ; *Electroencephalography ; Female ; *Functional Laterality ; Humans ; Male ; Memory/physiology ; Movement ; Pattern Recognition, Visual/physiology
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  • 22
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    Alteration of cortical orientation selectivity: importance of asymmetric input (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-08
    Description: Rearing cats so that each of the two eyes sees stripes of a different orientation alters the orientation preference of visual cortex cells. This result can be obtained by rearing the cats in striped cylinders or with goggles attached to their faces, but a tighter control of orientation preference is achieved by the goggles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gordon, B -- Presson, J -- Packwood, J -- Scheer, R -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1109-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451557" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Functional Laterality ; Orientation/*physiology ; Visual Cortex/cytology/*growth & development/physiology ; Visual Perception/*physiology
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  • 23
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    Effect of beta-endorphin on calcium uptake in the brain (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-05
    Description: The uptake of 45Ca2+ by nerve-ending fractions from brains of mice was inhibited in vitro by 10(-9)M concentrations of beta-endorphin and in mice injected intraventricularly with 7 picomoles of beta-endorphin. That the effect was a specific opiate agonist response of beta-endorphin was demonstrated by use of the opiate antagonist, naloxone, which reversed the action. A role for beta-endorphin in the regulation of calcium flux and neurotransmitter release should be considered.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guerrero-Munoz, F -- de Lourdes Guerrero, M -- Way, E L -- Li, C H -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):89-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/39340" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport/drug effects ; Calcium/*metabolism ; Dose-Response Relationship, Drug ; Drug Tolerance ; Endorphins/antagonists & inhibitors/*pharmacology ; Male ; Mice ; Naloxone/pharmacology ; Neurotransmitter Agents/metabolism ; Rats ; Synaptosomes/*drug effects/metabolism
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  • 24
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    Vitamin D deficiency and reproduction in rats (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-04-06
    Description: Female weanling rats from a colony maintained on a diet low in vitamin D were raised on a diet that was deficient in vitamin D but was otherwise adequate. Vitamin D deficiency was confirmed in the rats by hypocalcemia and the absence of vitamin D metabolites in blood. These females gave birth to litters that were slightly smaller than control litters from females maintained on a vitamin D-containing diet. The pups from the vitamin D-deficient mothers appeared normal throughout lactation, and at weaning had normal concentrations of calcium and phosphate in the plasma. These results indicate that vitamin D and its metabolites are not necessary for reproduction and fetal development in the rat.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Halloran, B P -- DeLuca, H F -- New York, N.Y. -- Science. 1979 Apr 6;204(4388):73-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432628" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Suckling/blood ; Body Weight ; Bone Development ; Calcium/blood ; Female ; Hydroxycholecalciferols/blood ; Phosphates/blood ; Rats ; *Reproduction ; Vitamin D Deficiency/blood/*physiopathology
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  • 25
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    Cerebral norepinephrine: influence on cortical oxidative metabolism in situ (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-10-05
    Description: Unilateral lesion of the locus coeruleus and the resultant norepinephrine depletion in the ipsilateral cerebrum alters the relationship between cerebral metabolic demands and local delivery of oxygen and substrates. This effect of norepinephrine depletion is demonstrated by slower recovery of the redox ratio of cytochrome a,a3 during increased metabolic demands induced by local cortical stimulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harik, S I -- LaManna, J C -- Light, A I -- Rosenthal, M -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):69-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482927" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cerebral Cortex/*metabolism ; Cytochromes/*metabolism ; Energy Metabolism ; Evoked Potentials ; Locus Coeruleus/*physiology ; Male ; Norepinephrine/*physiology ; Oxidation-Reduction ; Rats ; Spectrophotometry
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  • 26
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    Human skin fibroblasts derived from papillary and reticular dermis: differences in growth potential in vitro (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-04
    Description: Papillary fibroblasts, when compared to reticular fibroblasts from the same skin specimen, exhibit greater proliferative capacities in vitro. These results demonstrate a difference in function between morphologically similar cells obtained from the same tissue. Such findings represent an important consideration in the study of cell aging in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harper, R A -- Grove, G -- New York, N.Y. -- Science. 1979 May 4;204(4392):526-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432659" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Division ; Female ; Fibroblasts/cytology ; Humans ; Male ; Skin/*cytology
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  • 27
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    Radioimmunoassay of the insulin receptor: a new probe of receptor structure and function (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-09
    Description: A sensitive and specific radioimmunoassay for the insulin receptor has been developed employing receptor autoantibodies from the serum of a patient with insulin-resistant diabetes. The assay detects insulin binding sites at concentrations as low as 0.1 nanomolar; distinguishes between receptors originating from human placental membranes, human lymphoblastoid cells, and mouse liver membranes; and measures the receptor independently of its binding function. Down-regulation, or loss of binding after exposure to insulin, is associated with loss of immunoreactive receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harrison, L C -- Flier, J -- Itin, A -- Kahn, C R -- Roth, J -- New York, N.Y. -- Science. 1979 Feb 9;203(4380):544-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/83675" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigen-Antibody Reactions ; Binding Sites ; Binding Sites, Antibody ; Epitopes ; Female ; Humans ; Liver/analysis ; Lymphocytes/analysis ; Mice ; Placenta/analysis ; Pregnancy ; Radioimmunoassay/methods ; Receptor, Insulin/analysis/*immunology ; Solubility
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    Ketone bodies are selectively used by individual brain regions (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-07-20
    Description: Close study of 3-hydroxybutyrate uptake by brain suggests that its metabolism is limited by permeability. Furthermore, the permeability characteristics vary from region to region; areas known to have no blood-brain barrier show the highest rate of utilization. The results imply that rather than substitute fuels, ketone bodies should be considered supplements which partially supply specific areas but are incapable of supporting the entire energy requirement of all brain regions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hawkins, R A -- Biebuyck, J F -- New York, N.Y. -- Science. 1979 Jul 20;205(4403):325-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451608" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood-Brain Barrier ; Brain/*metabolism ; Glucose/metabolism ; Hydroxybutyrates/metabolism ; Ketone Bodies/*metabolism ; Male ; Rats ; Starvation/metabolism
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  • 29
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    Smallpox death in Britain challenges presumption of laboratory safety (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hawkes, N -- New York, N.Y. -- Science. 1979 Mar 2;203(4383):855-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/419409" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Female ; Great Britain ; Humans ; Jurisprudence ; Laboratories/*standards ; Peer Review ; Safety ; Smallpox/*etiology ; World Health Organization
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  • 30
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    Cancer and environment: Higginson speaks out (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-09-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Higginson, J -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1363-4, 1366.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472753" target="_blank"〉PubMed〈/a〉
    Keywords: Behavior ; *Carcinogens ; Diet ; *Environment ; Female ; Humans ; Life Style ; Male ; Neoplasms/*etiology ; Stress, Psychological/complications
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  • 31
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    Iodine-125--labeled estradiol: a gamma-emitting analog of estradiol that binds to the estrogen receptor (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-09-14
    Description: 17 beta-[16 alpha-125I]Iodoestradiol has been synthesized by exchange of 16 beta-bromoestradiol with Na125I. The iodinated product is readily separated from the bromo reactant by column chromatography. It concentrates in the rat uterus in vivo and binds avidly and specifically to the uterine estrogen receptor in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hochberg, R B -- New York, N.Y. -- Science. 1979 Sep 14;205(4411):1138-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472733" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Estradiol/*analogs & derivatives/analysis/metabolism ; Female ; Iodine Radioisotopes ; Radioimmunoassay/methods ; Rats ; Receptors, Estrogen/*metabolism ; Uterus/metabolism
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  • 32
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    Stimulation of human periaqueductal gray for pain relief increases immunoreactive beta-endorphin in ventricular fluid (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-01-19
    Description: Immunoreactive beta-endorphin was measured in the ventricular fluid of six patients with chronic pain. Stimulation of the periaqueductal gray matter in three patients with pain of peripheral origin resulted in significant increases (50 to 300 percent) in the concentration of ventricular immunoreactive beta-endorphin. In three other patients suffering deafferentation dysesthesia, stimulation of the posterior limb of the internal capsule did not alter the concentration of this peptide. These results provide evidence of the release of human immunoreactive beta-endorphin in vivo and suggest that naloxone-reversible pain relief achieved by stimulation of the periaqueductal gray matter may be in part mediated by the activation of beta-endorphin-rich diencephalic areas.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hosobuchi, Y -- Rossier, J -- Bloom, F E -- Guillemin, R -- New York, N.Y. -- Science. 1979 Jan 19;203(4377):279-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/83674" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Brain/*physiology ; Cerebral Aqueduct ; Electric Stimulation ; Endorphins/*cerebrospinal fluid/immunology ; Enkephalins/cerebrospinal fluid ; Female ; Humans ; Male ; Middle Aged ; Palliative Care/methods ; Radioimmunoassay
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  • 33
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    Tissue perfusion rate determined from the decay of oxygen-15 activity after photon activation in situ (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-15
    Description: Rates of cerebral perfusion were obtained from measurements of the disappearance (wash-out) of oxygen-15 after in situ tissue activation with 45-million-volt x-rays. In an anesthetized cat, typical values were 90 milliliters per minute per 100 grams of tissue, with 55 percent wash-out. In a specific radiotherapy patient, the value was 65 milliliters per minute per 100 grams of tissue, with 63 percent wash-out of oxygen-15 through incorporation into tissue water.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hughes, W L -- Nussbaum, G H -- Connolly, R -- Emami, B -- Reilly, P -- New York, N.Y. -- Science. 1979 Jun 15;204(4398):1215-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451567" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*blood supply ; Cats ; Humans ; Neoplasms/blood supply ; Oxygen/*blood/radiation effects ; Oxygen Radioisotopes ; *Regional Blood Flow ; X-Rays
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  • 34
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    Mammary cancer: selective action of the estrogen receptor complex (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-26
    Description: Progesterone receptors in the autonomous rat mammary tumor MTW-9B are reduced 80 to 90 percent after ovariectomy, but are not reduced if ovariectomized animals are given estrogen. Tumor growth, however, is independent of estrogen status and insensitive to pharmacological doses of estradiol. This represents an unusual system characterized by a selective action of an inducing agent on the genome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ip, M -- Milholland, R J -- Rosen, F -- Kim, U -- New York, N.Y. -- Science. 1979 Jan 26;203(4378):361-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760195" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Castration ; Cytosol/metabolism ; Estradiol/metabolism/pharmacology ; Female ; Male ; Mammary Neoplasms, Experimental/*metabolism ; Rats ; Receptors, Estrogen/*metabolism ; Receptors, Progesterone/biosynthesis/drug effects/*metabolism
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    DNA polymerase with characteristics of reverse transcriptase purified from human milk (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-05-04
    Description: A DNA polymerase purified from a particulate fraction of human milk has biochemical and biophysical properties similar to those of viral reverse transcriptases. This enzyme is immunologically distinct from cellular DNA polymerases obtained from a variety of human sources.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kantor, J A -- Lee, Y H -- Chirikjian, J G -- Feller, W F -- New York, N.Y. -- Science. 1979 May 4;204(4392):511-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/86209" target="_blank"〉PubMed〈/a〉
    Keywords: DNA-Directed DNA Polymerase/immunology/*metabolism ; Female ; Humans ; Milk, Human/*enzymology ; Molecular Weight ; RNA-Directed DNA Polymerase/immunology/*metabolism ; Retroviridae/enzymology ; Substrate Specificity ; Templates, Genetic
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  • 36
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    3-Methoxy-4-hydroxyphenethyleneglycol production by human brain in vivo (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-07
    Description: A direct method has been employed to estimate the rate of production by human brain of 3-methoxy-4-hydroxyphenethyleneglycol, the major metabolite of brain norepinephrine, a brain neurotransmitter. Venous specimens were obtained from the internal jugular vein from ten awake human subjects at a puncture site above the common facial vein, the first major source of extracranial inflow. Arterial specimens were simultaneously obtained from the radial artery. Plasma samples were assayed and a highly significant difference was found in the concentration of the metabolite in plasma coming out of the brain (venous blood) as compared to plasma entering the brain (arterial blood). This venous-arterial difference was calculated to be 0.7 +/- 0.1 nanogram per milliliter of blood. Assuming an adult brain weight of 1400 grams and normal cerebral blood flow, it is estimated that the rate of production of 3-methoxy-4-hydroxyphenethyleneglycol by the awake human brain is approximately 597 nanograms per minute or 35.8 micrograms per hour. Urine specimens were also collected from six of these subjects during a period of 1 to 3.5 hours, which bracketed the time the blood samples were obtained. For these six subjects the output of 3-methyoxy-4-hydroxyphenethyleneglycol by whole brain was estimated to be 40.9 micrograms per hour, whereas the rate of its excretion into urine was 64.5 micrograms per hour.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maas, J W -- Hattox, S E -- Greene, N M -- Landis, D H -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1025-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472724" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Brain/*metabolism ; Cerebrovascular Circulation ; Female ; Glycols/*metabolism ; Humans ; Male ; Methoxyhydroxyphenylglycol/blood/*metabolism/urine ; Middle Aged ; Norepinephrine/metabolism
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    Imbalance in X-chromosome expression: evidence for a human X-linked gene affecting growth of hemopoietic cells (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: In each of six family members who were heterozygous at the X-linked locus for glucose-6-phosphate dehydrogenase, only one or the other of the two alleles at that locus was almost exclusively expressed. The data are consistent with evidence that X-chromosome inactivation is a random process that may be followed by selection for one of the two resulting cell types on the basis of an unknown gene, which is located on the X chromosome and which can affect the rate of proliferation of hemopoietic cells in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Luzzatto, L -- Usanga, E A -- Bienzle, U -- Esan, G F -- Fusuan, F A -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1418-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472761" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Erythrocytes/enzymology ; Female ; Genetic Linkage ; Glucosephosphate Dehydrogenase/blood/genetics ; *Hematopoiesis ; Heterozygote ; Humans ; Leukocytes/enzymology ; *Mosaicism ; *Sex Chromosomes ; *X Chromosome
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  • 38
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    Hippocampal afterdischarges: differential spread of activity shown by the [14C]deoxyglucose technique (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-11
    Description: Differential spread of afterdischarge activity initiated electrically in ventral and dorsal parts of the hippocampal formation was studied by the [14C]deoxyglucose technique in rats. Afterdischarges initiated in either the ventral or dorsal hippocampal formation, without activation of the ventral subicular cortex, increased glucose utilization in the lateral septum. In contrast, afterdischarges initiated by direct activation of the ventral subicular cortex increased glucose utilization in extensive areas of the ipsilateral amygdala, claustrum, hypothalamus, preoptic region, and basal forebrain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kliot, M -- Poletti, C E -- New York, N.Y. -- Science. 1979 May 11;204(4393):641-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432672" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Brain/*metabolism ; Brain Mapping ; Deoxy Sugars/*metabolism ; Deoxyglucose/*metabolism ; Diencephalon/metabolism ; Electric Stimulation ; Epilepsy/physiopathology ; Hippocampus/*physiology ; Male ; Neural Pathways/physiology ; Rats
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  • 39
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    Fever and reduced iron: their interaction as a host defense response to bacterial infection (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-26
    Description: When rabbits are infected with Pasteurella multocida, the concentration of iron in their plasma decreases and their rectal temperature rises. To determine whether the rise in body temperature (fever) and the fall in plasma iron may be a coordinated host defense response, Pasteurella multocida were grown in vitro at various temperatures and iron concentrations. At afebrile temperatures the bacteria grew equally well at low or high concentrations of iron. However, when the temperature of the bath was raised to a febrile temperature the growth of the bacteria was inhibited by the low, but not the high, iron concentrations. These data support the hypothesis that one of the mechanisms behind the adaptive (or beneficial) role of fever is the reduced ability of pathogenic bacteria to grow well at elevated temperatures in an iron-poor medium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kluger, M J -- Rothenburg, B A -- New York, N.Y. -- Science. 1979 Jan 26;203(4378):374-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760197" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Fever/blood/*physiopathology ; Iron/*blood ; Longevity ; Male ; Pasteurella/growth & development ; Pasteurella Infections/physiopathology ; Rabbits
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  • 40
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    Treatment reduces deaths from hypertension (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1386-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505012" target="_blank"〉PubMed〈/a〉
    Keywords: Antihypertensive Agents/therapeutic use ; Blood Pressure ; Diet, Sodium-Restricted ; Female ; Humans ; Hypertension/complications/*drug therapy/physiopathology ; Male ; Myocardial Infarction/etiology/prevention & control
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  • 41
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    Sex hormones and brain development (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):985-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/112680" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocortical Hyperfunction/physiopathology ; Animals ; Behavior/*physiology ; Behavior, Animal/physiology ; Brain/*growth & development ; Female ; Gonadal Steroid Hormones/*physiology ; Haplorhini ; Humans ; Male ; Preoptic Area/growth & development ; Rats ; Receptors, Estrogen/metabolism ; Sex Differentiation ; Testosterone/metabolism
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  • 42
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    Scientists attack report that obstetrical medications endanger children (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1979 Apr 27;204(4391):391-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/87012" target="_blank"〉PubMed〈/a〉
    Keywords: Anesthesia, Obstetrical/*adverse effects ; Child ; Child Development/*drug effects ; Child, Preschool ; Delivery, Obstetric/methods ; Developmental Disabilities/chemically induced ; Female ; Humans ; Infant ; Infant, Newborn ; Labor, Obstetric ; Methods ; Pregnancy
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  • 43
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    Lateral geniculate nucleus in dark-reared cats: loss of Y cells without changes in cell size (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-30
    Description: In cats reared in the dark from birth until 4 months of age, the dorsal lateral geniculate nucleus contained few normal Y cells in either the binocular or monocular segments. Although most of the neurons appeared to be normal X cells unaffected by light deprivation, many cells with abnormal receptive field and response charcteristics were encountered. These effects were permanent, since 1 to 2 years of normal visual experience following initial light deprivation did not lead to any functional recovery. The sizes of cell bodies in cats reared in the dark were similar to those of normal animals, an indication that changes in geniculate cell physiology need not be related to changes in cell size.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kratz, K E -- Sherman, S M -- Kalil, R -- New York, N.Y. -- Science. 1979 Mar 30;203(4387):1353-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424758" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Darkness ; Functional Laterality ; Geniculate Bodies/*cytology/growth & development ; *Vision, Ocular ; Visual Pathways/cytology/*growth & development
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  • 44
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    Moment of inertia: psychophysical study of an overlooked sensation (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-02
    Description: The distribution of mass in an object held in the hand, as described by its moment of inertia, is a fundamental and potent but largely unrecognized contributor to the object's "feel." A limited set of experiments has produced Weber fractions for human differential sensitivity to this property in the approximate range of 1/5 to 1/3, which is about ten times the Weber fraction reported for lifted weights.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kreifeldt, J G -- Chuang, M C -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):588-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493965" target="_blank"〉PubMed〈/a〉
    Keywords: Biophysical Phenomena ; *Biophysics ; Female ; Humans ; Male ; Weight Perception/*physiology
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  • 45
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    Movement disorders of aged rats: reversal by dopamine receptor stimulation (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-26
    Description: When placed in a tank of water, aged rats (24 to 27 months old) showed marked impairments in swimming. Compared with young adult rats (3 to 4 months old), the older animals moved their limbs less vigorously and were less successful in keeping their heads above water. The young, but not old, rats maintained a position nearly horizontal to the water surface and planed across it. These movement dysfunctions of aged rats resemble those seen in young adult animals that have sustained injury to brain dopamine-containing neurons. The swimming impairments of the aged rats were reversed by the dopamine receptor stimulant apomorphine and by the biosynthetic precursor of dopamine, L-dopa. Thus, age-related alterations in brain dopaminergic systems may be responsible for some of the movement disturbances associated with senescence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, J F -- Berrios, N -- New York, N.Y. -- Science. 1979 Oct 26;206(4417):477-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/504992" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Apomorphine/therapeutic use ; Levodopa/therapeutic use ; Male ; Movement Disorders/drug therapy/*physiopathology ; Rats ; Receptors, Dopamine/*physiology ; Swimming ; Time Factors
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  • 46
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    The annual Pap smear: an idea whose time has gone? (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):177-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451586" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Female ; Humans ; Mass Screening/*economics ; Middle Aged ; *Papanicolaou Test ; Risk ; Socioeconomic Factors ; Uterine Cervical Neoplasms/epidemiology/*prevention & control ; Vaginal Smears/*economics
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  • 47
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    The HDL: the good cholestrol carriers? (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):677-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/223241" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Cholesterol/*blood/metabolism ; Diet ; Female ; Humans ; Lipoproteins, HDL/*blood ; Lipoproteins, LDL/blood ; Male ; Middle Aged ; Myocardial Infarction/etiology ; Risk ; Running ; Sex Factors ; Tissue Distribution
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  • 48
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    Virus isolated from juvenile diabetic (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1979 Jun 15;204(4398):1187.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/221976" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; Coxsackievirus Infections/*complications ; Diabetes Mellitus, Type 1/etiology/*microbiology ; Enterovirus B, Human ; Humans ; Male
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  • 49
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    Pharmacologic effects in man of a potent, long-acting dopamine receptor agonist (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-14
    Description: Single-dose administration of pergolide mesylate (100 to 400 micrograms) results in a dose-related inhibition of prolactin secretion which persists for more than 24 hours. During multiple-dose administration of pergolide, plasma prolactin concentrations remain markedly reduced (greater than 80 percnet) and gradually return to control levels several days after drug administration is discontinued.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lemberger, L -- Crabtree, R E -- New York, N.Y. -- Science. 1979 Sep 14;205(4411):1151-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/382359" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Clinical Trials as Topic ; Dose-Response Relationship, Drug ; Ergolines/*pharmacology/therapeutic use ; Humans ; Informed Consent ; Male ; Middle Aged ; Placebos ; Prolactin/blood ; Receptors, Dopamine/*drug effects ; Time Factors
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  • 50
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    Clomid administration to pregnant rats causes abnormalities of the reproductive tract in offspring and mothers (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-11
    Description: In rats, a single injection of clomiphene citrate (Clomid) during pregnancy causes multiple abnormalities of the reproductive tract in the offspring and mothers. These abnormalities probably result from the ability of Clomid to cause long-term estrogenic stimulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCormack, S -- Clark, J H -- New York, N.Y. -- Science. 1979 May 11;204(4393):629-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432668" target="_blank"〉PubMed〈/a〉
    Keywords: Abnormalities, Drug-Induced/*pathology ; Animals ; Clomiphene/*toxicity ; Fallopian Tubes/pathology ; Female ; Metaplasia ; Pregnancy ; Pregnancy, Animal/*drug effects ; Rats ; Uterine Diseases/chemically induced/pathology ; Vaginal Diseases/chemically induced
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    Reversal potential for noradrenaline-induced hyperpolarization of spinal motoneurons (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-07-27
    Description: By using two separate electrodes with tips inside a single feline motoneuron, current-voltage characteristics were studied during extracellular iontophoresis of noradrenaline. The usually observed hyperpolarization was accompanied by an increase in membrane resistance and became larger with polarizing and smaller with depolarizing currents. During large depolarizing current injections, the noradrenaline-induced potential reversed its direction, usually at a membrane potential of about -20 millivolts. These data are compatible with the concept that noradrenaline hyperpolarizes nerve cells by decreasing resting membrane conductances to sodium and potassium ions. The observation could also be explained by a nonspecific decrease in ion permeability that is associated with a hyperpolarization due to sodium pump activation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, K C -- Engberg, I -- New York, N.Y. -- Science. 1979 Jul 27;205(4404):422-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451613" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Membrane Potentials/drug effects ; Neurons/drug effects/*physiology ; Norepinephrine/*pharmacology ; Potassium/metabolism ; Sodium/metabolism ; Spinal Cord/drug effects/*physiology
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  • 52
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    Insulin receptor binding in obesity: a reassessment (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-09-07
    Description: A defect in the binding of insulin to circulating monocytes occurs when obese patients are hospitalized and fed a liberal carbohydrate diet. Under ordinary circumstances, most obese patients have normal insulin binding despite very high concentrations of serum insulin. These results show that insulin does not necessarily regulate its own receptor in vivo--as it does in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Misbin, R I -- O'Leary, J P -- Pulkkinen, A -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1003-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472718" target="_blank"〉PubMed〈/a〉
    Keywords: Dietary Carbohydrates/metabolism ; Female ; Humans ; Insulin/blood ; Insulin Resistance ; Male ; Monocytes/metabolism ; Obesity/*metabolism ; Physical Exertion ; Receptor, Insulin/*metabolism
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  • 53
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    Platelet aggregation induced by ultrasound under specialized conditions in vitro (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-08-03
    Description: Human platelets were induced by 2.1-megahertz ultrasound to form aggregates around gas-filled pores in membranes immersed in platelet-rich plasma. The spatial peak intensities required were only about 16 to 32 milliwatts per square centimeter. Ultrasound generated by a medical Doppler device, whose intensity exceeded this, induced aggregate formation under the same conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, D L -- Nyborg, W L -- Whitcomb, C C -- New York, N.Y. -- Science. 1979 Aug 3;205(4405):505-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451616" target="_blank"〉PubMed〈/a〉
    Keywords: Blood Platelets/radiation effects/*ultrastructure ; Humans ; Male ; Microscopy, Electron, Scanning ; Platelet Aggregation/*radiation effects ; *Ultrasonics
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  • 54
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    Functional organization of lateral geniculate cells following removal of visual cortex in the newborn kitten (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-09
    Description: When the visual cortex of a newborn kitten is removed, most neurons in the dorsal lateral geniculate nucleus degenerate, but a small population of large cells is spared. Electrophysiological recording revealed that detailed visual topography in the nucleus is abnormal and that single cells have unusually large receptive fields. These results suggest that optic axons deprived of their normal synaptic targets rearrange their connections to converge on local surviving neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murphy, E H -- Kalil, R -- New York, N.Y. -- Science. 1979 Nov 9;206(4419):713-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493978" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn/anatomy & histology ; Cats ; Functional Laterality ; Geniculate Bodies/*cytology ; Nerve Degeneration ; Visual Cortex/*cytology ; Visual Pathways/*cytology/growth & development
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    Antennal hair erection in male mosquitoes: a new mechanical effector in insects (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-02
    Description: Male Anopheles mosquitoes erect their antennal hairs prior to mating. The erectile mechanism resides in a unique annulus at the base of each hair whorl. It appears that the insect regulates the degree of hydration of this annulus. When the annulus is made to swell the attached hairs are pushed to their erect position.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nijhout, H F -- Sheffield, H G -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):595-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/40308" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anopheles/*physiology/ultrastructure ; Behavior, Animal/physiology ; Hair/physiology ; Hydrogen-Ion Concentration ; Male ; Microvilli/physiology ; Movement ; Proteins/physiology ; Water
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    Dynamic changes in circulating 1,25-dihydroxyvitamin D during reproduction in rats (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-29
    Description: The concentrations of 1,25-dihydroxyvitamin D [1,25-(OH)2D], calcium, and phosphorus were measured in the serum of rats during pregnancy and at various stages of lactation. The concentration of 1,25-(OH)2D hormone increased almost two-fold during pregnancy and the latter part of lactation, but decreased to control levels or very low values immediately after birth and weaning, respectively. Furthermore, the concentration of 1,25-(OH)2D was inversely correlated with the concentration of calcium, suggesting that circulating 1,25-(OH)2D fluctuates in concert with calcium demands during the reproductive cycle. Parathyroidectomy in lactating rats caused a 70 percent inhibition of the normally observed 1,25-(OH)2D increase, indicating that parathyroid hormone, in response to changes in serum calcium, is a primary modulator of 1,25-(OH)2D during lactation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pike, J W -- Parker, J B -- Haussler, M R -- Boass, A -- Toverud, S V -- New York, N.Y. -- Science. 1979 Jun 29;204(4400):1427-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451573" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/blood ; Dihydroxycholecalciferols/*blood ; Female ; Hydroxycholecalciferols/*blood ; *Lactation ; Parathyroid Glands/physiology ; Parathyroid Hormone/physiology ; Phosphorus/blood ; Pregnancy ; *Pregnancy, Animal ; Rats
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    Target cells for 1,25-dihydroxyvitamin D3 in intestinal tract, stomach, kidney, skin, pituitary, and parathyroid (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-07
    Description: After mature rats that had been fed on a vitamin D3-deficient diet were injected with tritium-labeled 1,25-dihydroxyvitamin D3, radioactivity became concentrated in nuclei of luminal and cryptal epithelium of the duodenum, jejunum, ileum, and colon; in nuclei of the epithelium of kidney distal tubules including the macula densa, and in podocytes of glomeruli; in nuclei of the epidermis including outer hairshafts and sebaceous glands; and in nuclei of certain cells of the stomach, anterior and posterior pituitary, and parathyroid. These results reveal cell types that contain receptors for 1,25-dihydroxyvitamin D3 or metabolites of this compound both in known or hypothesized target tissues and in tissues that were previously unknown to participate in vitamin D3 metabolism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stumpf, W E -- Sar, M -- Reid, F A -- Tanaka, Y -- DeLuca, H F -- New York, N.Y. -- Science. 1979 Dec 7;206(4423):1188-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505004" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoradiography ; Cell Nucleus/metabolism ; Cytoplasm/metabolism ; Digestive System/*metabolism ; Dihydroxycholecalciferols/*metabolism ; Hydroxycholecalciferols/*metabolism ; Intestinal Mucosa/metabolism ; Kidney/*metabolism ; Male ; Parathyroid Glands/*metabolism ; Pituitary Gland/*metabolism ; Rats ; Skin/*metabolism ; Stomach/metabolism
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    Microwave radiation and chlordiazepoxide: synergistic effects on fixed-interval behavior (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-03-30
    Description: In the presence of low-intensity pulsed microwave radiation, at an average power density of 1 milliwatt per square centimeter, the response-rate-increasing effects of chlordiazepoxide were potentiated in rats. The behavioral effects of a drug can be modified by brief exposure to a low-level microwave field even when the radiation level alone has no apparent effects on the behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thomas, J R -- Burch, L S -- Yeandle, S S -- New York, N.Y. -- Science. 1979 Mar 30;203(4387):1357-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424759" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/drug effects/*radiation effects ; Chlordiazepoxide/*pharmacology ; Dose-Response Relationship, Drug ; Dose-Response Relationship, Radiation ; Male ; *Microwaves ; Rats
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    Nickel carbonyl: prenatal exposure (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Warner, J S -- New York, N.Y. -- Science. 1979 Mar 23;203(4386):1194-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424746" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Drug ; Female ; Humans ; Ketones/*toxicity ; Nickel/*toxicity ; Occupational Medicine ; Pregnancy ; Rats ; *Teratogens
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    Starvation-induced decreased sensitivity of resting metabolic rate to triiodothyronine (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-09-21
    Description: The decrease in resting oxygen consumption induced by starvation was found to occur not only in euthyroid rats but also in hypothyroid and even in hypothyroid animals treated with triiodothyronine. Furthermore, the effectiveness of triiodothyronine was decreased when given to hypothyroid animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wimpfheimer, C -- Saville, E -- Voirol, M J -- Danforth, E Jr -- Burger, A G -- New York, N.Y. -- Science. 1979 Sep 21;205(4412):1272-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224460" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Drug ; Energy Metabolism/drug effects ; Hypothyroidism/metabolism ; Male ; Oxygen Consumption/*drug effects ; Rats ; Receptors, Cell Surface/drug effects ; Starvation/*metabolism ; Triiodothyronine/*pharmacology
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    Sucrose consumption early in life fails to modify the appetite of adult rats for sweet foods (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-07-20
    Description: Male rats consumed a diet containing 0, 12, or 48 percent sucrose on days 16 to 30 of life. Thereafter, they had simultaneous access to all three diets until day 63. No relationship was detected between sucrose consumption early in life and subsequent preference for sucrose. The onset of puberty was associated with a decreased appetite for sucrose among animals of both sexes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wurtman, J J -- Wurtman, R J -- New York, N.Y. -- Science. 1979 Jul 20;205(4403):321-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451607" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Dietary Carbohydrates ; Food Preferences/*drug effects ; Male ; Rats ; Saccharin ; Sexual Maturation ; Sucrose/*pharmacology ; Taste
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    Phase advance of the circadian sleep-wake cycle as an antidepressant (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-11-09
    Description: Sleep in depressed patients resembles sleep in normal subjects whose circadian rhythms of temperature and rapid-eye-movement sleep are phase-advanced (shifted earlier) relative to their sleep schedules. If this analogy is relevant to the pathophysiology of depressive illness, advancing the time of sleep and awakening should temporarily compensate for the abnormal timing of depressed patients' circadian rhythms. Four of seven manic-depressive patients studied longitudinally spontaneously advanced their times of awakening (activity onset) as they emerged from the depressive phase of their illness. In a phase-shift experiment, a depressed manic-depressive woman was twice brought out of depression for 2 weeks by advancing her sleep period so that she went to sleep and arose 6 hours earlier than usual. The antidepressant effect of the procedure was temporary and similar in duration to circadian desynchronization induced by jet lag in healthy subjects. This result supports the hypothesis that abnormalities of sleep patterns in some types of depression are due to abnormal internal phase relationships of circadian rhythms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wehr, T A -- Wirz-Justice, A -- Goodwin, F K -- Duncan, W -- Gillin, J C -- New York, N.Y. -- Science. 1979 Nov 9;206(4419):710-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/227056" target="_blank"〉PubMed〈/a〉
    Keywords: Bipolar Disorder/*physiopathology/therapy ; Body Temperature Regulation ; *Circadian Rhythm ; Female ; Humans ; Middle Aged ; Motor Activity/physiology ; Sleep, REM/*physiology
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    Hyperthermia and local anesthetics: potentiation of survival of tumor-bearing mice (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-07-13
    Description: Lidocaine infusion of a CA755 mammary adenocarcinoma growing in the hind leg of BDF1 mice results in a significant increase in the animals' survival when combined with heating for 1 hour in a 43.5 degrees C water bath. This ability of local anesthetics to prolong survival following hyperthermia is consistent with the hypothesis that increases in membrane fluidity influence sensitivity to heat. In view of the extensive clinical experience with local anesthetics, the delay between clinical application and the observation that they potentiate the action of hyperthermia in animals may be reduced.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yatvin, M B -- Clifton, K H -- Dennis, W H -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):195-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451588" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/therapy ; Anesthetics, Local/*therapeutic use ; Animals ; Female ; *Hot Temperature ; Lidocaine/therapeutic use ; Mammary Neoplasms, Experimental/therapy ; Membrane Fluidity/drug effects ; Mice ; Neoplasms, Experimental/*therapy
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    Intraventricular carbachol mimics the effects of light on the circadian rhythm in the rat pineal gland (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-01-26
    Description: Environmental lighting regulates numerous circadian rhythms, including the cycle in pineal serotonin N-acetyltransferase activity. Brief exposure of rats to light can shift the phase of this enzyme's circadian rhythm. Light also rapidly reduces nocturnal enzyme activity. Intraventricular injections of carbachol, a cholinergic agonist, can mimic both of these effects. Light and carbachol presumably act on the suprachiasmatic nucleus of the hypothalamus. These experiments demonstrate the feasibility of using a neuropharmacologic approach to the mechanisms underlying mammalian circadian rhythms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zatz, M -- Brownstein, M J -- New York, N.Y. -- Science. 1979 Jan 26;203(4378):358-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/32619" target="_blank"〉PubMed〈/a〉
    Keywords: Acetyltransferases/metabolism ; Animals ; Biological Clocks/drug effects ; Carbachol/administration & dosage/*pharmacology ; Circadian Rhythm/*drug effects/radiation effects ; Injections, Intraventricular ; *Light ; Male ; Neurotransmitter Agents/pharmacology ; Pineal Gland/enzymology/*physiology ; Rats ; Serotonin
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    Surgeon general seeks physicians' help in DES alert (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-01-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1979 Jan 12;203(4376):159.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/758685" target="_blank"〉PubMed〈/a〉
    Keywords: Diethylstilbestrol/*adverse effects ; Drug Information Services ; Female ; Government Agencies ; Humans ; Mesonephroma/*chemically induced ; United States ; Vaginal Neoplasms/*chemically induced
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    Effects of anesthesia (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-02-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1979 Feb 23;203(4382):705.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/419403" target="_blank"〉PubMed〈/a〉
    Keywords: *Abnormalities, Drug-Induced ; Abortion, Spontaneous/*chemically induced ; Anesthetics/*adverse effects ; Female ; Humans ; Male ; Pregnancy
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    Delayed neurotoxicity of phenylphosphonothioate esters (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-08-17
    Description: Administration of a single oral dose of five phenylphosphonothioate esters produced delayed neurotoxicity in hens; their potency was, in descending order, cyanofenphos, EPN, desbromoleptophos, leptophos, and EPBP (Seven). Histological examination showed that in some hens there was marked axonal and myelin degeneration in the spinal cord and peripheral nerves. The results suggest that delayed neurotoxicity may be a general feature of phenylphosphonothioate insecticides.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abou-Donia, M B -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):713-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462181" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ataxia/chemically induced ; Chickens ; Demyelinating Diseases/chemically induced ; Dose-Response Relationship, Drug ; Female ; Insecticides/*toxicity ; Nerve Degeneration ; *Neurotoxins ; *Organothiophosphorus Compounds ; Time Factors
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    A direct role of dopamine in the rat subthalamic nucleus and an adjacent intrapeduncular area (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-12-21
    Description: The subthalamic nucleus, a clinically important component of the extrapyramidal motor system, and a lateral area extending into the peduncle contain catecholamine terminals and dopamine receptors coupled to adenylate cyclase. In addition, dopamine agonists administered in vivo enhance glucose utilization in the region. Thus, neuronal function in this region is directly affected by dopamine and dopaminergic drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, L L -- Markman, M H -- Wolfson, L I -- Dvorkin, B -- Warner, C -- Katzman, R -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1416-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505015" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/metabolism ; Animals ; Brain Mapping ; Catecholamines/pharmacology ; Dopamine/pharmacology ; Enzyme Activation/drug effects ; Extrapyramidal Tracts/*metabolism/ultrastructure ; Glucose/metabolism ; Male ; Mesencephalon/*metabolism ; Neurons/metabolism ; Rats ; Receptors, Dopamine/*metabolism
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    Menopausal flushes: a neuroendocrine link with pulsatile luteninizing hormone secreation (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-08-24
    Description: Menopausal flush episodes were found to be invariably associated with the initiation of pulsatile pituitary release of luteinizing hormone. This was not accompanied by a significant change in circulating catecholamine or prolactin concentrations. Since pulsatile luteinizing hormone release results from episodic secretion of luteinizing hormone releasing factor by the hypothalamus, these findings suggest a link between the neuroendocrine mechanisms that initiate such episodic secretion and those responsible for the onset of flush episodes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Casper, R F -- Yen, S S -- Wilkes, M M -- New York, N.Y. -- Science. 1979 Aug 24;205(4408):823-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462193" target="_blank"〉PubMed〈/a〉
    Keywords: *Climacteric ; Dopamine/blood ; Epinephrine/blood ; Female ; Follicle Stimulating Hormone/blood ; Humans ; Luteinizing Hormone/blood/*secretion ; Middle Aged ; Norepinephrine/blood ; Prolactin/blood
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    Prolonged inhibition of neurons by neuroendocrine cells in Aplysia (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-04-27
    Description: In the abdominal ganglion of Aplysia, a burst of action potentials in peptide-secreting neuroendocrine cells, the bag cells, produces slow inhibition of two identified bursting pacemaker neurons. The inhibition is due to slow hyperpolarizing potential that reduces bursting pacemaker activity for 3 hours or more. The slow inhibitory potential results from a large and prolonged increase in membrane conductance to potassium ions as well as a slower ionic process that is relatively independent of membrane conductance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brownell, P -- Mayeri, E -- New York, N.Y. -- Science. 1979 Apr 27;204(4391):417-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/35827" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Aplysia/*physiology ; Electric Conductivity ; Electric Stimulation ; Female ; Ganglia/physiology ; *Neural Inhibition ; Neurosecretory Systems/*physiology ; Neurotransmitter Agents/physiology ; Oviposition ; Peptides/physiology
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    2-Deoxy-D-glucose maps movement-specific nervous activity in the second visual ganglion of Drosophila (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-08-17
    Description: Adult Drosophila were fed with tritium labeled deoxyglucose prior to a 5-hour period of visual stimulation. A flickering disk of light and a moving grating were presented to the left and right eyes, respectively. Autoradiography revealed enhanced labeling solely in that part of the second optic ganglion (medulla) whose visual field was stimulated by movement.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Buchner, E -- Buchner, S -- Hengstenberg, R -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):687-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/111349" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Deoxy Sugars/*metabolism ; Deoxyglucose/*metabolism ; Drosophila melanogaster/anatomy & histology/*physiology ; Female ; Ganglia/metabolism ; Motion Perception/*physiology ; Neurons/*metabolism ; Visual Pathways/metabolism ; Visual Perception/physiology
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    Evidence for extra-renal 1 alpha-hydroxylation of 25-hydroxyvitamin D3 in pregnancy (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-22
    Description: The kidneys are thought to be the only organs capable of 1 alpha-hydroxylation of vitamin D and its metabolites. We have examined the in vivo conversion of 3H-(25,26)-25-hydroxyvitamin D3(25OHD3) to 3H-(25,26)-1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3] in vitamin D-deficient, pregnant and nonpregnant rats. As expected, nephrectomy of nonpregnant, vitamin D-deficient rats prevented the conversion of 25OHD3 to 1 alpha,25(OH)2D3. In contrast, nephrectomy of pregnant, vitamin D-deficient rats reduced but did not abolish the formation of 1 alpha,25(OH)2D3 from its precursor. The identity of the radioactive metabolite formed from 3H-25OHD3 which circulated in nephrectomized, pregnant rats was established as 1 alpha,25(OH)2D3 by comigration with synthetic 1 alpha,25(OH)2D3 on high-pressure liquid chromatography. The simultaneous absence of 1 alpha,25(OH)2D3 in the fetal kidneys indicated that the site of 1 alpha-hydroxylation after nephrectomy of the pregnant rat was probably extra-renal in origin. Two sites of 1 alpha-hydroxylation of 25OHD3, one renal and the other extra-renal, either fetoplacental or maternal, may exist in the pregnant, vitamin D-deficient rat.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gray, T K -- Lester, G E -- Lorenc, R S -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1311-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451538" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dihydroxycholecalciferols/biosynthesis ; Female ; Fetal Blood/metabolism ; Hydroxycholecalciferols/*metabolism ; Hydroxylation ; Kidney/embryology/metabolism ; *Nephrectomy ; Placenta/metabolism ; Pregnancy ; *Pregnancy, Animal
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    Opiate antagonists: a role in the treatment of hypovolemic shock (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-20
    Description: The opiate antagonist naloxone has been used to treat shock following acute blood loss in conscious rats. Naloxone treatment rapidly increased mean arterial pressure and pulse pressure in this new shock model. More importantly, these blood pressure changes were sustained and survival was significantly increased with maloxone as compared with placebo treatment. From these findings, it may be inferred that endorphins may play a role in the pathophysiology of hypovolemic shock. It is suggested that narcotic antagonists may prove to be of therapeutic value in the treatment of shock.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Faden, A I -- Holaday, J W -- New York, N.Y. -- Science. 1979 Jul 20;205(4403):317-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451606" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Pressure ; Hypotension/drug therapy ; Male ; Naloxone/*therapeutic use ; Rats ; Shock/*drug therapy/physiopathology
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  • 74
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    [Interpreting "imitative" responses in early infancy] (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jacobson, S W -- Kagan, J -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):215-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451595" target="_blank"〉PubMed〈/a〉
    Keywords: Behavior/*physiology ; Female ; Humans ; *Infant ; *Infant, Newborn ; Male ; Movement ; Tongue/physiology
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  • 75
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    Nonpneumonic, short-incubation-period Legionellosis (Pontiac fever) in men who cleaned a steam turbine condenser (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: Pontiac fever affected ten men who had cleaned a steam turbine condenser with compressed air. Previous epidemics of Pontiac fever and Legionnaires' disease--both caused by Legionella Pneumophila (proposed sp. nov.)--involved "airborne spread" from air-conditioning cooling towers or evaporative condensers. Aerosols of contaminated water in heat-rejection systems appear to be important sources of epidemic legionellosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fraser, D W -- Deubner, D C -- Hill, D L -- Gilliam, D K -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):690-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462175" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Air Microbiology ; Humans ; Legionnaires' Disease/*etiology/microbiology/transmission ; Male ; Occupational Medicine ; Time Factors
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  • 76
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    Pseudohermaphroditism in Ilyanassa obsoleta (Mollusca: Neogastropoda) (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: Field studies, a rearing and maintenance program, and a transfer experiment have shown that anomalous male traits found in some female Ilyanassa obsoleta are an expression of environmentally controlled psuedohermaphroditism. The particular pattern of pseudohermaphroditism discovered in this species has not been reported previously from any other group, but may be characteristic of the Neogastropoda.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jenner, M G -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1407-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472758" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disorders of Sex Development/pathology/*physiopathology ; Female ; Male ; Sex Differentiation ; Snails/growth & development/*physiology
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  • 77
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    Genetic resistance to aflatoxin in Japanese quail (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: Progress was rapid in attempts to develop lines of quail resistant to acute aflatoxicosis induced by oral dosing with aflatoxin. After five generations of selection, 8- and 11-fold differences were present in mortality between two selected lines and their respective control lines. These quail lines should be of value in investigating the physiological basis of resistance to aflatoxin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marks, H L -- Wyatt, R D -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1329-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/515737" target="_blank"〉PubMed〈/a〉
    Keywords: Aflatoxins/*pharmacology ; Animals ; Coturnix/*genetics ; *Drug Resistance ; Female ; Genes ; Male ; Quail/*genetics ; Selection, Genetic
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  • 78
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    On the specificity of kainic acid (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-06-22
    Description: The specificity of the neurotoxic agent, kainic acid, for destroying cell bodies while sparing terminals and fibers of passage was examined by infusing this agent into the axons of the dorsal noradrenergic bundle and measuring the degree of depletion of noradrenaline concentrations and the reduction in noradrenaline uptake in cortex and hippocampus. Extensive neuronal loss and gliosis were observed around the injection site. In addition, a significant and consistent 25 percent depletion of hippocampal-cortical noradrenaline was also obtained. The results suggest that although kainic acid has its greatest destructive action on neuronal perikarya, a significant amount of damage to axons of passage may also occur.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mason, S T -- Fibiger, H C -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1339-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451544" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic Fibers/*drug effects ; Animals ; Brain/metabolism ; Brain Stem/cytology/drug effects ; Cerebral Cortex/drug effects ; Hippocampus/drug effects ; Hydroxydopamines/pharmacology ; Kainic Acid/*pharmacology ; Locus Coeruleus/drug effects ; Male ; Neurons/*drug effects/ultrastructure ; Norepinephrine/metabolism ; Pyrrolidines/*pharmacology ; Rats
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  • 79
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    Blood substitute passes its first test (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1979 Oct 12;206(4415):205.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482936" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Emulsions ; Fluorocarbons/*therapeutic use ; Humans ; Male ; Plasma Substitutes/*therapeutic use
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  • 80
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    Dysmenorrhea: basic research leads to a rational therapy (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):175-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/109921" target="_blank"〉PubMed〈/a〉
    Keywords: Cyclooxygenase Inhibitors ; Dysmenorrhea/drug therapy/*physiopathology ; Female ; Humans ; Progesterone/physiology ; Prostaglandins/*physiology ; Uterine Contraction
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  • 81
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    Subfornical organ efferents to neural systems for control of body water (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-09-07
    Description: The subfornical organ, a circumventricular structure of the central nervous system, has efferent neural projections to sites within the brain known to be involved in drinking behavior and secretion of antidiuretic hormone. By using anterograde tracing techniques, it is shown that the subfornical organ projects to the nucleus medians of the medial preoptic area, to the organum vasculosum of the lamina terminalis, and to the supraoptic nuclei bilaterally. Its efferent connectivity is confirmed by retrograde transport of horseradish peroxidase. The organum vasculosum of the lamina terminalis, another circumventricular organ and a suspected receptor site for angiotensin II, is involved in the circuitry of the subfornical organ and also has an efferent projection to the supraoptic nuclei.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miselis, R R -- Shapiro, R E -- Hand, P J -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1022-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472723" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/cytology ; Cerebral Ventricles/*cytology ; Drinking Behavior/physiology ; Efferent Pathways/physiology ; Male ; Neurosecretory Systems/*physiology ; Preoptic Area/cytology ; Rats ; Subfornical Organ/cytology/*physiology ; Supraoptic Nucleus/cytology ; *Water-Electrolyte Balance
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  • 82
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    Albumin-deficient rat mutant (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-10
    Description: An analbuminemic colony was established from Sprague-Dawley rats. Analbuminemia was inherited as an autosomal recessive trait. The rates of growth and reproduction of the mutant rats were no different from those of normal rats. Biochemically, the mutant was characterized by an extraordinarily low serum albumin content and a hyperlipidemia. Total serum protein in the mutant rat was similar to that of control Sprague-Dawley rats, with increased globulin. Serum cholesterol was inversely correlated with a decrease in albumin; the correlation coefficient for ablumin was --.92. These mutant rats may serve as a model of human familial analbuminemia and may also be useful in elucidating the functional roles of albumin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nagase, S -- Shimamune, K -- Shumiya, S -- New York, N.Y. -- Science. 1979 Aug 10;205(4406):590-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451621" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Aberrations/*blood ; Chromosome Disorders ; Crosses, Genetic ; Female ; Immunoelectrophoresis ; Male ; Mutation ; Rats/*genetics ; Serum Albumin/*deficiency ; Serum Globulins/analysis
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  • 83
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    Can an ape create a sentence? (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-23
    Description: More than 19,000 multisign utterances of an infant chimpanzee (Nim) were analyzed for syntactic and semantic regularities. Lexical regularities were observed in the case of two-sign combinations: particular signs (for example, more) tended to occur in a particular position. These regularities could not be attributed to memorization or to position habits, suggesting that they were structurally constrained. That conclusion, however, was invalidated by videotape analyses, which showed that most of Nim's utterances were prompted by his teacher's prior utterance, and that Nim interrupted his teachers to a much larger extent than a child interrupts an adult's speech. Signed utterances of other apes (as shown on films) revealed similar non-human patterns of discourse.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Terrace, H S -- Petitto, L A -- Sanders, R J -- Bever, T G -- New York, N.Y. -- Science. 1979 Nov 23;206(4421):891-902.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/504995" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Communication ; Animals ; Humans ; Language Development ; Male ; Pan troglodytes/*physiology ; Semantics ; Sign Language ; Time Factors
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  • 84
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    Triglyceride concentrations: the disaccharide effect (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-11-16
    Description: The mean 24-hour or integrated concentration of triglyceride is significantly higher when dietary sucrose is provided rather than an equivalent amount of its component monosaccharides, glucose and fructose. In contrast, the plasma triglyceride concentration after a 12-hour fast is not significantly different.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thompson, R G -- Hayford, J T -- Hendrix, J A -- New York, N.Y. -- Science. 1979 Nov 16;206(4420):838-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493983" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Dietary Carbohydrates/*metabolism ; Fructose/metabolism ; Glucose/metabolism ; Humans ; Male ; Sucrose/metabolism ; Triglycerides/*blood
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  • 85
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    Calmodulin activation of adenylate cyclase in pancreatic islets (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-12
    Description: Pancreatic islets contain calmodulin. The protein binds to a particulate fraction derived from the islets and stimulates adenylate cyclase activity in this subcellular fraction, both phenomena being activated by ionized calcium. A calcium-dependent stimulation of adenylate cyclase by endogenous calmodulin may contribute to the accumulation of adenosine 3',5'-monophosphate evoked by insulin releasing agents in the islet cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Valverde, I -- Vandermeers, A -- Anjaneyulu, R -- Malaisse, W J -- New York, N.Y. -- Science. 1979 Oct 12;206(4415):225-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/225798" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/*metabolism ; Animals ; Calcium/*physiology ; Calcium-Binding Proteins/*metabolism ; Calmodulin/*metabolism ; Cell Membrane/metabolism ; Cyclic AMP/metabolism ; Egtazic Acid/metabolism ; Enzyme Activation ; Female ; Glucose/pharmacology ; Insulin/*secretion ; Islets of Langerhans/*enzymology ; Kinetics ; Rats
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  • 86
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    Semliki forest virus: cause of a fatal case of human encephalitis (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-03-16
    Description: A fatal case of human encephalitis has been observed for which our results indicate that Semliki Forest virus (SFV) was the etiologic agent. This is surprising in view of the fact that this virus, which has been widely studied, was believed to be one of the arboviruses nonpathogenic for man. Described are the clinical course, the virological examinations performed, and the histopathological findings in the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Willems, W R -- Kaluza, G -- Boschek, C B -- Bauer, H -- Hager, H -- Schutz, H J -- Feistner, H -- New York, N.Y. -- Science. 1979 Mar 16;203(4385):1127-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424742" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Antigens, Viral/analysis ; Arbovirus Infections/*etiology ; Encephalitis/*etiology/microbiology/pathology ; Female ; Humans ; Laboratory Infection/*etiology/microbiology ; *Semliki forest virus/immunology
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  • 87
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    The hyperactive child syndrome (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-09-28
    Description: The behavioral characteristics of the hyperactive child are described at different stages of development. Recent and sometimes controversial research findings are discussed with respect to prevalence, etiology, treatment, and outcome. It is concluded that this syndrome can best be understood in terms of interactions between social, psychological, and biological variables.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weiss, G -- Hechtman, L -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1348-54.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472752" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Attention Deficit Disorder with Hyperactivity/etiology ; Child ; Child Behavior Disorders/diagnosis/*etiology/therapy ; Child, Preschool ; Environment ; Female ; Humans ; Infant ; Male ; Methylphenidate/therapeutic use ; Sex Ratio ; Syndrome ; Terminology as Topic
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  • 88
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    Intestinal absorption of immune complexes by neonatal rats: a route of antigen transfer from mother to young (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-02
    Description: Horseradish peroxidase (HRP) in the presence of specific immunoglobulin G antibody to HRP is selectively absorbed from the gut lumen and transferred by intestinal epithelial cells to the lamina propria in newborn rats. The HRP is not transferred in detectable amounts in the absence of the antibody. Transport of maternally derived antigen via antigen-antibody complexes may have important influences on the developing immune system in young mammals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abrahamson, D R -- Powers, A -- Rodewald, R -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):567-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493961" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn/*immunology ; *Antigen-Antibody Complex ; *Antigens ; Biological Transport, Active ; Female ; Horseradish Peroxidase/immunology ; Immunoglobulin Fab Fragments ; Immunoglobulin Fc Fragments ; *Intestinal Absorption ; Jejunum/*immunology/metabolism ; Male ; Rats
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  • 89
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    Physostigmine and recent memory: effects in young and aged nonhuman primates (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-11-30
    Description: The effect of physostigmine on recent memory was evaluated in young and aged rhesus monkeys. All aged monkeys had previously shown impaired memory. The performance of the young monkeys treated with physostigmine was similar to that recently reported for young humans--no effects at low doses, some improvement at a restricted range of doses, and deficits at the highest dose. Although the aged subjects also improved at the same general doses, their overall response as a group was much more variable than that of the younger subjects. The performance of some aged monkeys was impaired by low doses that did not affect young monkeys. Continued improvement was observed in some aged monkeys at the highest dose, which typically impaired young monkeys. These variable effects across aged subjects suggest that physostigmine cannot easily or reliably be used as an agent for treating geriatric cognition. Nevertheless, the differential age-related effects suggest that appropriate manipulation of the cholinergic system may eventually be developed to alleviate some of the cognitive impairments suffered by aged subjects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bartus, R T -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1087-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/227061" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/physiology ; Aging ; Animals ; Cognition/physiology ; Female ; Haplorhini ; Humans ; Male ; Memory/*drug effects ; Memory Disorders/drug therapy ; Memory, Short-Term/drug effects ; Physostigmine/*pharmacology/therapeutic use ; Synaptic Transmission
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 90
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    "Sontaneous" neoplastic transformation in vitro: a form of foreign body (smooth surface) tumorigenesis (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-13
    Description: Explants of subcutaneous connective tissue from adult BALB/c mice into plastic petri dishes were serially subcultured and tested for tumorigenicity in two ways: by the subcutaneous implantation of cells attached to plastic plates (1 by 5 by 10 millimeters), and by the subcutaneous injection of cells suspended in saline. Cells grown in vitro for 18 or more days before being implanted attached to a plastic plate (2.4 x 10(4) to 3.4 x 10(5) cells per plate) formed tumors after 24 to 79 weeks. The latent period before tumor appearance correlated inversely with the time spent by the cells in tissue culture. Cells inoculated in saline suspension (10 to 100 times the above number per plate) did not form tumors until after 84 days in vitro; plates alone did not induce tumor formation within more than 1 1/2 years of implantation. The tumors arising from the plate-attached cells were transplantable without plates and histologically appeared to be undifferentiated sarcomas. It is well established that smooth-surfaced foreign bodies, regardless of their chemical composition, will produce sarcomas when transplanted subcutaneously in rodents. We interpret our data, particularly the decrease in tumor latent period with time spent in tissue culture, as indicating that a smooth surface was acting as a carcinogen first in vitro (the surface of the tissue culture dish) and then in vivo (the surface of the plastic plate).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boone, C W -- Takeichi, N -- Eaton, S D -- Paranjpe, M -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):177-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/373119" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Transformation, Neoplastic/pathology ; Cells, Cultured ; Connective Tissue/pathology ; Female ; Foreign-Body Reaction/*complications ; Mice ; Neoplasms, Experimental/*etiology ; *Plastics ; Sarcoma, Experimental/etiology ; Time Factors
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Fetal research ethics (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brackbill, Y -- New York, N.Y. -- Science. 1979 Oct 26;206(4417):404-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/504983" target="_blank"〉PubMed〈/a〉
    Keywords: Abortion, Induced ; Disclosure ; *Ethics, Medical ; Female ; Fetus/*physiology ; Humans ; Informed Consent ; Pregnancy ; *Risk Assessment
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 92
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    High anxiety over flights through ozone (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broad, W J -- New York, N.Y. -- Science. 1979 Aug 24;205(4408):767, 769.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462189" target="_blank"〉PubMed〈/a〉
    Keywords: *Aerospace Medicine ; Female ; Humans ; Male ; Occupational Diseases/*chemically induced ; Ozone/*poisoning
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 93
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    Ethanol embryotoxicity: direct effects on mammalian embryos in vitro (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-02
    Description: Exposure to ethanol retards growth and differentiation in cultured rat embryos during organogenesis. The development of untreated embryos is indistinguishable from growth in utero. These data suggest that the hypoplastic features of children born to chronically alcoholic mothers are due, at least in part, to a direct action of ethanol, which causes reduced embryonic cellular proliferation early in gestation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, N A -- Goulding, E H -- Fabro, S -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):573-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/573922" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Drug ; Ectogenesis/*drug effects ; Embryo, Mammalian/*drug effects ; Ethanol/*toxicity ; Female ; Fetal Growth Retardation/chemically induced ; Pregnancy ; Rats ; *Teratogens
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 94
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    Temperature-dependent sex determination in turtles (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-07
    Description: The sex of hatchling map turtles is determined by incubation temperature of eggs in the laboratory as well as in nature. Temperature controls sex differentiation rather than causing a differential mortality of sexes. Temperature has no effect on sex determination in a soft-shelled turtle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bull, J J -- Vogt, R C -- New York, N.Y. -- Science. 1979 Dec 7;206(4423):1186-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505003" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Genotype ; Male ; *Sex Determination Analysis ; Species Specificity ; Temperature ; Turtles/*physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 95
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    Release of luteinizing hormone in male mice during exposure to females: habituation of the response (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: Male mice release luteinizing hormone when exposed for a short time to a female. In this experiment, multiple blood samples were withdrawn by atrial cannulas from tethered males during either continuous or intermittent exposure to nonreceptive females. After an immediate, transient release of luteinizing hormone, continuous exposure to the same female was accompanied by only random, spontaneous elevations in plasma levels of this hormone. Successive presentations of the same female at 2-hour intervals elicited gradually diminishing luteinizing hormone responses. Exposing such unresponsive males to novel, diestrous females, however, dramatically stimulated their release of the hormone. These results demonstrate habituation of a socially induced, neuroendocrine response involving reproductive hormones.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coquelin, A -- Bronson, F H -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1099-101.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/573924" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arousal/physiology ; Diestrus ; Female ; Habituation, Psychophysiologic/*physiology ; Luteinizing Hormone/*metabolism ; Male ; Mice ; Pregnancy ; Sexual Behavior, Animal/physiology
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  • 96
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    5-Bromodeoxyuridine inhibits sequence changes within inverted repeat DNA during embryogenesis (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-24
    Description: Previous studies on the genome of Strongylocentrotus purpuratus sea urchin have shown that changes in the nucleotide sequence of inverted repeat sequences occur during embryogenesis. The present study indicates that these sequence changes fail to occur when the embryos are raised in the presence of 5-bromodeoxyuridine. This drug is an analog of thymidine, is incorporated into the DNA during embryogenesis, and inhibits cell differentiation in these embryos.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dickinson, D G -- Baker, R F -- New York, N.Y. -- Science. 1979 Aug 24;205(4408):816-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/572583" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence/*drug effects ; Bromodeoxyuridine/*pharmacology ; DNA Replication/*drug effects ; Female ; Ovum/*metabolism ; Sea Urchins
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  • 97
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    Human chorionic gonadotropin: induction of ovulation in the squirrel monkey (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-12
    Description: The minimum dose of human chorionic gonadotropin that would cause ovulation in the squirrel monkey (Saimiri sciureus) was found to be between 100 and 250 international units.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dukelow, W R -- New York, N.Y. -- Science. 1979 Oct 12;206(4415):234-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/113874" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chorionic Gonadotropin/administration & dosage/*pharmacology ; Dose-Response Relationship, Drug ; Female ; Follicle Stimulating Hormone/pharmacology ; Haplorhini/*physiology ; Ovulation/*drug effects ; Saimiri/*physiology
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  • 98
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    To know with the nose: keys to odor identification (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-02
    Description: Successful odor identification depends on (i) commonly encountered substances, (ii) a long-standing connection between an odor and its name, and (iii) aid in recalling the name. The absence of any one ingredient impairs performance dramatically, but the presence of all three permits ready identification of scores of substances, with performance seemingly limited only by the inherent confusability of the stimuli.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cain, W S -- New York, N.Y. -- Science. 1979 Feb 2;203(4379):467-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760202" target="_blank"〉PubMed〈/a〉
    Keywords: Feedback ; Female ; Humans ; Memory/physiology ; Odors ; Smell/*physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 99
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    Cyclic AMP receptor triggers nuclear protein phosphorylation in a hormone-dependent mammary tumor cell-free system (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: Adenosine 3',5'-monophosphate (cyclic AMP) receptor protein of 56,000 daltons increases markedly in mammary tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) after incubation of tumor slices with cyclic AMP, benzamide, and arginine. Incubation of cytosol from these tumor slices with nuclei from unincubated tumors results in nuclear uptake of the 56,000-dalton cyclic AMP receptor and in phosphorylation of the 76,000-dalton nuclear protein. Binding of the 56,000-dalton receptor and phosphorylation of the 76,000-dalton protein also occur in DMBA tumor nuclei when protein kinase type II of bovine heart is used. The results suggest that cyclic AMP receptor is involved in the nuclear events of a hormone-dependent mammary tumor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cho-Chung, Y S -- Archibald, D -- Clair, T -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1390-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224463" target="_blank"〉PubMed〈/a〉
    Keywords: 9,10-Dimethyl-1,2-benzanthracene ; Animals ; Cell Nucleus/metabolism ; Cell-Free System ; Chromosomal Proteins, Non-Histone/*metabolism ; Cyclic AMP/*metabolism ; Female ; Mammary Neoplasms, Experimental/*metabolism ; Neoplasm Proteins/metabolism ; Phosphorylation ; Protein Kinases/*metabolism ; Rats ; Receptors, Cyclic AMP/*metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 100
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    Food deprivation increases oral and intravenous drug intake in rats (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-20
    Description: Rats given continuous access to etonitazene hydrochloride in their drinking water (5 micrograms per milliliter) more than doubled their drug intake while deprived of food. Another group of rats with implanted jugular catheters self-administered etonitazene (10 micrograms per kilogram) intravenously on a continuous reinforcement schedule, and the number of infusions increased significantly on days when they were deprived of food. These results suggest that feeding condition may be a powerful determinant of drug-reinforced behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carroll, M E -- France, C P -- Meisch, R A -- New York, N.Y. -- Science. 1979 Jul 20;205(4403):319-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/36665" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Oral ; Animals ; Benzimidazoles/*administration & dosage ; Drinking Behavior ; *Food Deprivation ; Humans ; Injections, Intravenous ; Male ; Rats ; Self Administration ; Stereotyped Behavior/physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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