Publication Date:
1979-04-13
Description:
The intraventricular injection of D-alanine-methionine-enkephalinamide (D-Ala2-Met-enkephalinamide), a synthetic analog of Met-enkephalin that is resistant to enzymatic degradation, inhibits copulatory behavior in sexually vigorous male rats in doses which do not influence motor activity or feeding behavior. This effect is prevented by naloxone, a specific inhibitor of opioid receptors. In addition, injections of naloxone induce copulatory behavior in sexually inactive male rats. These results suggest that endorphins play an important role in the regulation of sexual behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gessa, G L -- Paglietti, E -- Quarantotti, B P -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):203-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432642" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Copulation/*drug effects
;
Endorphins/*pharmacology
;
Enkephalins/*pharmacology
;
Feeding Behavior/drug effects
;
Male
;
Motor Activity/drug effects
;
Naloxone/*pharmacology
;
Rats
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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