Clomid administration to pregnant rats causes abnormalities of the reproductive tract in offspring and mothers

Science. 1979 May 11;204(4393):629-31. doi: 10.1126/science.432668.

Abstract

In rats, a single injection of clomiphene citrate (Clomid) during pregnancy causes multiple abnormalities of the reproductive tract in the offspring and mothers. These abnormalities probably result from the ability of Clomid to cause long-term estrogenic stimulation.

MeSH terms

  • Abnormalities, Drug-Induced / pathology*
  • Animals
  • Clomiphene / toxicity*
  • Fallopian Tubes / pathology
  • Female
  • Metaplasia
  • Pregnancy
  • Pregnancy, Animal / drug effects*
  • Rats
  • Uterine Diseases / chemically induced
  • Uterine Diseases / pathology
  • Vaginal Diseases / chemically induced

Substances

  • Clomiphene