Publication Date:
1979-01-26
Description:
Progesterone receptors in the autonomous rat mammary tumor MTW-9B are reduced 80 to 90 percent after ovariectomy, but are not reduced if ovariectomized animals are given estrogen. Tumor growth, however, is independent of estrogen status and insensitive to pharmacological doses of estradiol. This represents an unusual system characterized by a selective action of an inducing agent on the genome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ip, M -- Milholland, R J -- Rosen, F -- Kim, U -- New York, N.Y. -- Science. 1979 Jan 26;203(4378):361-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760195" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Castration
;
Cytosol/metabolism
;
Estradiol/metabolism/pharmacology
;
Female
;
Male
;
Mammary Neoplasms, Experimental/*metabolism
;
Rats
;
Receptors, Estrogen/*metabolism
;
Receptors, Progesterone/biosynthesis/drug effects/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
