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  • Adult  (210)
  • Structure-Activity Relationship  (120)
  • American Association for the Advancement of Science (AAAS)  (329)
  • American Institute of Physics
  • Annual Reviews
  • 1980-1984  (234)
  • 1975-1979  (95)
  • 1945-1949
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  • American Association for the Advancement of Science (AAAS)  (329)
  • American Institute of Physics
  • Annual Reviews
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  • 1
    Publikationsdatum: 1978-06-02
    Beschreibung: Eight chronic alcoholics received repeated computed tomography scans. Four, who maintained abstinence and functionally improved, showed partially reversible cerebral atrophy. Two nonabstinent patients and two abstinent patients who had completed functional improvement before the first scan showed no change in atrophy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carlen, P L -- Wortzman, G -- Holgate, R C -- Wilkinson, D A -- Rankin, J C -- New York, N.Y. -- Science. 1978 Jun 2;200(4345):1076-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/653357" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Aged ; Alcoholism/*pathology/radiography/therapy ; Atrophy ; Brain/*pathology/radiography ; Female ; Humans ; Male ; Middle Aged ; Tomography, X-Ray Computed
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1978-05-05
    Beschreibung: Skin test reactivity, lymphocyte transformation, and mononuclear cell tissue factor generation were evaluated both before and during systemic anticoagulation in 24 volunteers. Anticoagulation with warfarin decreased skin test induration and tissue factor generation, but lymphocyte trnasformation remained unchanged. An intact coagulation mechanism, including tissue factor generation, appears to be important for the development of skin test induration in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Edwards, R L -- Rickles, F R -- New York, N.Y. -- Science. 1978 May 5;200(4341):541-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644314" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Antigens ; Fibrin/metabolism ; Humans ; Hypersensitivity, Delayed/*physiopathology ; Lymphocyte Activation/*drug effects ; Mitogens ; Skin Tests ; Thromboplastin/*biosynthesis ; Tuberculin ; Warfarin/*pharmacology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 3
    Publikationsdatum: 1978-03-24
    Beschreibung: Substance P produces analgesia when administered to mice in very small doses by the intraventricular route (1.25 to 5 nanograms per mouse). The analgesic effect can be blocked by naloxone. At higher doses (greater than 50 nanograms per mouse), this activity is lost. At these higher doses, however, substance P produced hyperalgesia when combined with naloxone and analgesia when combined with baclofen [beta-(4-chlorophenyl)-gamma-aminobutyric acid]. Substance P may have dual actions in brain, releasing endorphins at very low doses and directly exciting neuronal activity in nociceptive pathways at higher doses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frederickson, R C -- Burgis, V -- Harrell, C E -- Edwards, J D -- New York, N.Y. -- Science. 1978 Mar 24;199(4335):1359-62.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/204012" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Baclofen/pharmacology ; Dose-Response Relationship, Drug ; Endorphins/*pharmacology ; Enkephalins/antagonists & inhibitors/*pharmacology ; Mice ; Naloxone/pharmacology ; Nociceptors/*drug effects ; Receptors, Opioid/*drug effects ; Structure-Activity Relationship ; Substance P/analogs & derivatives/antagonists & inhibitors/*pharmacology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 4
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1978-10-27
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guillemin, R -- New York, N.Y. -- Science. 1978 Oct 27;202(4366):390-402.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/212832" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Endorphins/*history/isolation & purification/pharmacology ; Gonadotropin-Releasing Hormone/isolation & purification ; Growth Hormone-Releasing Hormone/isolation & purification ; History, 20th Century ; Hypothalamic Hormones/*history/pharmacology ; Hypothalamo-Hypophyseal System/*physiology ; *Neurosecretion ; Sheep ; Species Specificity ; Structure-Activity Relationship ; Synaptic Transmission ; Thyrotropin-Releasing Hormone/isolation & purification/physiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 5
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1978-03-17
    Beschreibung: The idea that hierarchically higher brain processes require greater amounts of central nervous system vigilance or activation for their execution was tested in two experiments measuring pupillary dilation during the decision interval of a hierarchically structured letter-matching task. Larger dilations indicative of increased activation were observed for letter pairs requiring higher levels of processing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beatty, J -- Wagoner, B L -- New York, N.Y. -- Science. 1978 Mar 17;199(4334):1216-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/628837" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Brain/*physiology ; Brain Stem/physiology ; Cognition/*physiology ; Decision Making/physiology ; Humans ; Information Theory ; Pupil/*physiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 6
    Publikationsdatum: 1978-03-17
    Beschreibung: Michigan dairy farm residents ate farm products containing polybrominated biphenyls (PBB's) after the accidential contamination of animal feed with the chemical in that state in 1973. The circulating blood lymphocytes of these residents show significant changes. Abnormalities include decreases in the numbers and percentages of peripheral blood lymphocytes that form rosettes with either sheep erythrocytes alone or with sheep erythrocytes sensitized with antibody and complement, increases in lymphocytes with no detectable surface markers ("null" cells), and altered responses to tests designed to evaluate functional integrity of the cells. There appears to be no consistent correlation between the concentration of PBB's in the plasma and the altered lymphocytes. Studies showed that in Wisconsin dairy farm residents and healthy individuals in the New York area who were not exposed to PBB's there were no such abnormalities.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bekesi, J G -- Holland, J F -- Anderson, H A -- Fischbein, A S -- Rom, W -- Wolff, M S -- Selikoff, I J -- New York, N.Y. -- Science. 1978 Mar 17;199(4334):1207-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/204005" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Biphenyl Compounds/*pharmacology ; Complement System Proteins/metabolism ; Environmental Exposure ; Humans ; Lectins ; Lymphocyte Activation/*drug effects ; Lymphocytes/*immunology ; Michigan ; Monocytes/physiology ; Polybrominated Biphenyls/blood/*pharmacology ; Rosette Formation ; Rural Health ; T-Lymphocytes/immunology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 7
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1978-05-26
    Beschreibung: Risk factors for disease consist of (i) personal habits, such as cigarette smoking and excessive alcohol consumption, and (ii) bodily characteristics, such as hypertension and high serum cholesterol. Progress in identifying and quantifying risk factors is opening the way to the prevention of disease and maintenance of health. Systematic, controlled trials of intervention against risk factors are beginning to produce evidence on the extent of success in reducing both the factors and the mortality from associated diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Breslow, L -- New York, N.Y. -- Science. 1978 May 26;200(4344):908-12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644333" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Arteriosclerosis/etiology ; Coronary Disease/etiology/*prevention & control ; Disease/*etiology ; Female ; Humans ; Hypercholesterolemia/complications ; Hypertension/complications ; Lung Neoplasms/etiology ; Male ; Middle Aged ; *Preventive Medicine ; *Probability ; *Risk ; Smoking/complications
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 8
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1978-04-21
    Beschreibung: The muscle activity of normal ambulatory individuals was recorded continuously for 8-hour (working day) periods. Parameters of activity patterns were defined and numerical outcomes for these parameters were compared across a diverse population of muscles. Several pattern parameters, such as the average percentage of time active, were highly correlated with the percentage of type I fibers of a muscle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Monster, A W -- Chan, H -- O'Connor, D -- New York, N.Y. -- Science. 1978 Apr 21;200(4339):314-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/635587" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Electromyography ; Humans ; Male ; *Muscle Contraction ; Muscles/anatomy & histology/*physiology ; Time Factors
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 9
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1978-03-31
    Beschreibung: All individuals tested in this study with sicca syndrome, a human autoimmune disease, bear two immunologically distinct and genetically unrelated B lymphocyte antigens that appear similar to the immune response associated (Ia) antigens of the mouse. The genes coding for these two antigens are present in only 37 and 24 percent of normal controls. In animal models Ia antigen genes are closely linked to immune response genes. Our findings suggest that two such genes may be required for the development of sicca syndrome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moutsopoulos, H M -- Chused, T M -- Johnson, A H -- Khudsen, B -- Mann, D L -- New York, N.Y. -- Science. 1978 Mar 31;199(4336):1441-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/415366" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Adult ; Aged ; Autoimmune Diseases/*immunology ; B-Lymphocytes/*immunology ; Female ; *Genes, MHC Class II ; Genetic Linkage ; HLA Antigens/analysis/genetics ; Humans ; Isoantigens/*analysis/genetics ; Male ; Middle Aged ; Sjogren's Syndrome/genetics/*immunology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 10
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1978-06-16
    Beschreibung: Sex differences in the pattern and maturation of lateral asymmetries of the human brain have been recently found by a number of investigators, suggesting that sex-related factors may differentially affect the two sides of the body. In this study, asymmetries in the size of the two feet were strongly related to sex and handedness, right-handed males having larger right feet and right-handed females having larger left feet, the reverse being seen in non-right-handed individuals. Since these differences were apparent even in children younger than 6 years, the fetal sex steroids may be critical in governing the maturation of both cerebral and pedal asymmetries.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levy, J -- Levy, J M -- New York, N.Y. -- Science. 1978 Jun 16;200(4347):1291-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663611" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Adult ; Age Factors ; Child ; Child, Preschool ; Female ; Foot/*anatomy & histology ; *Functional Laterality ; Genetic Linkage ; Humans ; Male ; *Sex Factors
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 11
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1978-05-26
    Beschreibung: Sampling of amniotic fluid, visualization of the fetus, fetal blood sampling, and screening of maternal blood represent successive approaches to the diagnosis of specific genetic disorders in the second trimester of pregnancy. Clinical and ethical concerns about the appropriateness, safety, and efficacy of the techniques have led to multidisciplinary assessments at an early stage. A major growth in demand for medical and educational genetic services can be anticipated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Omenn, G S -- New York, N.Y. -- Science. 1978 May 26;200(4344):952-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/77042" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Amniocentesis/adverse effects/methods ; Amniotic Fluid/analysis ; Chromosome Aberrations/diagnosis ; Chromosome Disorders ; Congenital Abnormalities/diagnosis ; Female ; Fetal Blood/analysis ; Fetoscopy/methods ; Genetic Diseases, Inborn/*diagnosis/therapy ; Humans ; Metabolism, Inborn Errors/diagnosis ; Pregnancy ; Prenatal Diagnosis/*methods ; Ultrasonography ; alpha-Fetoproteins/analysis
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 12
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1978-12-08
    Beschreibung: Nineteen epileptic patients were tested first under medium (week 1) and then under high (week 2) therapeutic levels of phenobarbital. Relative to response times of 20 controls with equivalent practice but without medication, response times of patients in a short-term memory scanning task were strikingly slowed during week 2. However, increased phenobarbital did not slow responses in a task requiring access to information in long-term memory.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉MacLeod, C M -- Dekabian, A S -- Hunt, E -- New York, N.Y. -- Science. 1978 Dec 8;202(4372):1102-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715461" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Dose-Response Relationship, Drug ; Epilepsy/*drug therapy ; Humans ; Memory, Short-Term/*drug effects ; Middle Aged ; Phenobarbital/adverse effects/*pharmacology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 13
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1978-04-14
    Beschreibung: Cocaine (2.0 milligrams per kilogram) given by the oral route is at least as effective as the same dose given intranasally. Cocaine is not detected in the plasma until 30 minutes after oral administration, but peak plasma concentrations are similar after both routes. The subjective "highs" in man are greater after oral than after intranasal administration.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van Dyke, C -- Jatlow, P -- Ungerer, J -- Barash, P G -- Byck, R -- New York, N.Y. -- Science. 1978 Apr 14;200(4338):211-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24895" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Administration, Intranasal ; Administration, Oral ; Adult ; Cocaine/*administration & dosage/blood/pharmacology ; Euphoria/drug effects ; Humans ; Hydrogen-Ion Concentration ; Intestinal Absorption ; Male ; Time Factors
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 14
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1978-03-10
    Beschreibung: Incubation of ribonuclease with 0.1M mercaptoethanol at pH 8.5 can increase the enzyme's hydrolytic activity toward cytidine 2',3'-monophosphate (cyclic CMP) under standard assay conditions. Cation-exchange chromatography of the ribonuclease-thiol reaction mixture revealed seven fractions. The fraction with the highest activity had an approximate tenfold decrease in the apparent Michaelis constant for cyclic CMP with respect to native ribonuclease. The enhanced activity is a metastable property since this fraction reverts back to the control activity and chromatographic behavior of native ribonuclease on standing in solution at room temperature.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Watkins, J B -- Benz, F W -- New York, N.Y. -- Science. 1978 Mar 10;199(4333):1084-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/564548" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cattle ; Disulfides/pharmacology ; Enzyme Activation/drug effects ; Glutathione/pharmacology ; Kinetics ; Mercaptoethanol/*pharmacology ; Oxidation-Reduction ; Pancreas/enzymology ; Protein Conformation ; Ribonucleases/*metabolism ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 15
    Publikationsdatum: 1978-07-07
    Beschreibung: Endogenous opiate-like peptides (endorphins) are putative neuroregulators located throughout the mammalian brainstem. There is some evidence for their role in pain, stress, and affect. We report that the opiate antagonist, naloxone, alters some schizophrenic symptoms. In a double-blind, cross-over study, naloxone produced decreases in auditory hallucinations in some schizophrenic patients. This finding supports the hypothesis that the endorphins may play a roll in modulating hallucinations in a highly selected subgroup of chronically hallucinating schizophrenic patients.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Watson, S J -- Berger, P A -- Akil, H -- Mills, M J -- Barchas, J D -- New York, N.Y. -- Science. 1978 Jul 7;201(4350):73-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/351804" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Chronic Disease ; Clinical Trials as Topic ; Dose-Response Relationship, Drug ; Double-Blind Method ; Endorphins/physiology ; Hallucinations/*drug therapy ; Humans ; Male ; Naloxone/administration & dosage/*therapeutic use ; Schizophrenia/*drug therapy/physiopathology ; Schizophrenia, Paranoid/drug therapy ; Time Factors
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    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 16
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1978-05-26
    Beschreibung: Defensive medicine--the use of diagnostic and end-treatment measures explicitly for the purposes of averting malpractice suits--is frequently cited as one of the least desirable effects of the current rise in medical litigation. Many physicians and policy-makers claim that defensive medicine is responsible not only for the increasing costs of health care but the exposing of patients to significant risks of harm from unnecessary procedures. Very little solid information is available about defensive medicine. The studies that have been conducted have been fraught with statistical difficulties and are by no means definitive. Even more important than the issue of defensive medicine is the more basic problem of our system of compensation for medical injuries.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tancredi, L R -- Barondess, J A -- New York, N.Y. -- Science. 1978 May 26;200(4344):879-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644329" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Cesarean Section/utilization ; Child ; Costs and Cost Analysis ; Craniocerebral Trauma/radiography ; *Defensive Medicine/economics ; Female ; Fetal Monitoring/utilization ; Humans ; *Malpractice/economics ; Physician-Patient Relations ; Pregnancy ; Quality of Health Care ; Surveys and Questionnaires ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 17
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1979-09-07
    Beschreibung: In the past two decades, biochemistry and molecular biology have demonstrated the existence of potentially exploitable biochemical differences between etiologic agents of disease and their hosts. Known differences between organism and host with respect to metabolism and polymer structure point to the detailed characterization of key proteins as the focus for the development of potential inhibitors. In the last decade, the methodology of the isolation, characterization, and inactivation of proteins and enzymes has been advanced. The present scientific and technological base suggests that new efforts toward the development of selective chemotherapeutic agents for infections caused by bacteria, viruses, protozoa, and higher eukaryotes should exploit the known differences in proteins or other specific biopolymers serving crucial structural or metabolic roles in the economy of the parasite.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, S S -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):964-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/382357" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Anti-Bacterial Agents ; *Antiviral Agents ; Communicable Diseases/*drug therapy ; Humans ; Mycobacterium leprae/metabolism ; Polysaccharides, Bacterial/metabolism ; Species Specificity ; Structure-Activity Relationship ; Trypanosomiasis/drug therapy ; Vidarabine/pharmacology ; Viral Proteins/biosynthesis ; Virus Replication/drug effects
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    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 18
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1979-04-13
    Beschreibung: Sediment in human urine examined by transmission electron microscopy contains amphibole fibers which originate from the ingestion of drinking water contaminated with these mineral fibers. The ingestion of filtered water results in the eventual disappearance of amphibole fibers from urine. These observations provide the first direct evidence for the passage of mineral fibers through the human gastro-intestinal mucosa under normal conditions of the alimentary canal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cook, P M -- Olson, G F -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):195-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/219478" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Aged ; Female ; Gastric Mucosa/metabolism ; Humans ; Intestinal Absorption ; Intestinal Mucosa/metabolism ; Male ; Middle Aged ; Silicon Dioxide/metabolism/*urine ; *Water Pollutants ; *Water Pollutants, Chemical
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 19
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    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1979-03-30
    Beschreibung: The amino terminal acid sequences of several mouse leukemia virus phosphoproteins (p12) show definite homology with the amino terminal conserved region of H5 histones, the phosphorylated nuclear proteins of nucleated erythrocytes. Differences in the amino acid compositions of the two groups of proteins seem to rule out the possibility that they evolved from a single common ancestral gene. The finding of sequence homology between viral p12's and cellular histones, however, is consistent with evolution of retrovirus structural proteins by a process of differentiation from preexisting cellular genes. The conserved primary and secondary structure at the amino terminal region, common to both groups of proteins, may be related to their common function of nucleic acid binding modulated by phosphorylation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Henderson, L E -- Gilden, R V -- Oroszlan, S -- New York, N.Y. -- Science. 1979 Mar 30;203(4387):1346-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/218289" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Animals ; Carrier Proteins ; Cell Nucleus/analysis ; Chickens/blood ; Erythrocytes/analysis ; Geese/blood ; *Histones ; Leukemia Virus, Murine/*analysis ; Nucleic Acids/metabolism ; *Phosphoproteins ; Structure-Activity Relationship ; *Viral Proteins
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 20
    Publikationsdatum: 1979-04-13
    Beschreibung: Cis and trans dichlorodiaminoplatinum (II) compounds bind to DNA and form DNA cross-links, which are usually considered to be irreversible. Thiourea can reverse these cross-links without any apparent breakdown of the DNA. In addition, cis- and trans-Pt (II) treatment of lambda decreases its transfectivity. After suitable incubation with thiourea, full transfectivity of Pt(II)-treated lambda DNA can be restored.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Filipski, J -- Kohn, K W -- Prather, R -- Bonner, W M -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):181-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/571145" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Coliphages ; DNA/*metabolism ; DNA, Neoplasm/metabolism ; DNA, Viral/metabolism ; Leukemia L1210 ; Organoplatinum Compounds/*antagonists & inhibitors ; Structure-Activity Relationship ; Thiourea/*pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 21
    Publikationsdatum: 1979-08-31
    Beschreibung: The Na+,k+-adenosine triphosphatase-inhibiting activity of digitalis genins and their analogs is a function of side-group carbonyl (C = O) oxygen position. For each 2.2 angstroms that this oxygen is displaced from its position in digitoxigenin, activity drops by one order of magnitude. This quantitative relation resolves previously proposed models which have attempted to describe the molecular basis of genin activity. A multidisciplinary (crystallographic, conformational energy, synthetic, biological) approach to structure-activity relations is described.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fullerton, D S -- Yoshioka, K -- Rohrer, D C -- From, A H -- Ahmed, K -- New York, N.Y. -- Science. 1979 Aug 31;205(4409):917-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224455" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Brain/enzymology ; Digitalis Glycosides/*pharmacology ; Molecular Conformation ; Rats ; Sodium-Potassium-Exchanging ATPase/*antagonists & inhibitors ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 22
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    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1979-12-14
    Beschreibung: Current concepts of the pathogenesis of emphysema suggest that it results from an imbalance of elastase and antielastase activity within the alveolar structures. Although emphysema that is associated with hereditary deficiency of serum alpha 1-antitrypsin conforms to this scheme, the major risk factor in the more common form of emphysema is cigarette smoking. A study was designed to evaluate the premise that cigarette smoking may be associated with an acquired, functional defect in lung alpha 1-antitrypsin. Determination of the antielastase activity of alpha 1-antitrypsin obtained from the lungs of smoking and nonsmoking individuals revealed a nearly twofold reduction in the functional activity of this elastase inhibitor in the lungs of cigarette smokers. These data suggest that cigarette smokers may lose some of the normal antielastase protective screen of the lower respiratory tract, making them more vulnerable to destructive lung disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gadek, J E -- Fells, G A -- Crystal, R G -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1315-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/316188" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Bronchi/enzymology ; Extracellular Space/enzymology ; Humans ; Lung/*enzymology ; Pancreatic Elastase/antagonists & inhibitors ; Plants, Toxic ; Pulmonary Emphysema/enzymology/etiology ; Smoking/complications/*physiopathology ; Tobacco ; *alpha 1-Antitrypsin Deficiency
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 23
    Publikationsdatum: 1979-02-16
    Beschreibung: By means of two-stage, nonlinear multivariate pattern recognition, electroencephalograms (EEG's) were analyzed during performance of verbal and spatial tasks. Complex scalp distributions of theta-, beta-, and, to a lesser extent, alpha-band spectral intensities discriminated between the two members of a pair of tasks, such as writing sentences and Koh's block design. Small EEG asymmetries were probably attributable to limb movements and other uncontrolled noncognitive aspects of tasks. Significant EEG differences beteeen cognitive tasks were eliminated when controls for inter-task differences in efferent activity, stimulus characteristics, and performance-related factors were introduced. Each controlled task was associated with an approximately 10 percent reduction, as compared with visual fixation, in the magnitude of alpha- and beta-band spectral intensity. This effect occurred bilaterally and was approximately the same over occipital, parietal, and central regions, with some minor difference over the frontal region in the beta band. With these controls, no evidence for lateralization of different cognitive functions was found in the EEG.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gevins, A S -- Zeitlin, G M -- Doyle, J C -- Yingling, C D -- Schaffer, R E -- Callaway, E -- Yeager, C L -- New York, N.Y. -- Science. 1979 Feb 16;203(4381):665-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760212" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Cerebral Cortex/*physiology ; Cognition/*physiology ; *Electroencephalography ; Female ; *Functional Laterality ; Humans ; Male ; Memory/physiology ; Movement ; Pattern Recognition, Visual/physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 24
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1979-09-07
    Beschreibung: Iodinated beta H-[2-D-alanine]endorphin exhibits specific binding to cultured human lymphocytes. The binding is inhibited by low concentrations of beta-endorphin and its D-alanine derivative, but is not affected by opiate agonists and antagonists, or by enkephalin analogs, beta-lipotropin, adrenocorticotrophic hormone, or alpha-melanocyte-stimulating hormone; this suggests the existence of a specific, non-opiate binding site (receptor) for beta-endorphin. The carboxy-terminal region of beta-endorphin is essential for this binding activity, since alpha-endorphin is not active. beta-Endorphin may be a circulating hormone with peripheral physiological effects that are not primarily mediated through interactions with opiate or enkephalin receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hazum, E -- Chang, K J -- Cuatrecasas, P -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1033-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224457" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Cells, Cultured ; Endorphins/blood/*metabolism ; Humans ; Lymphocyte Activation ; Lymphocytes/*metabolism ; Receptors, Drug/*metabolism ; Receptors, Opioid/metabolism ; Stress, Physiological/metabolism ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 25
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1979-03-02
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hawkes, N -- New York, N.Y. -- Science. 1979 Mar 2;203(4383):855-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/419409" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Female ; Great Britain ; Humans ; Jurisprudence ; Laboratories/*standards ; Peer Review ; Safety ; Smallpox/*etiology ; World Health Organization
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 26
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    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1979-03-09
    Beschreibung: Movement time varies as a function of amplitude and requirements for precision, according to Fitts' law, but when subjects perform two-handed movements to targets of widely disparate difficulty they do so simultaneously. The hand moving to an "easy" target moves more slowly to accommodate its "difficult" counterpart, yet both hands reach peak velocity and acceleration synchronously. This result suggests that the brain produces simultaneity of action not by controlling each limb independently, but by organizing functional groupings of muscles that are constrained to act as a single unit.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kelso, J A -- Southard, D L -- Goodman, D -- New York, N.Y. -- Science. 1979 Mar 9;203(4384):1029-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424729" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Brain/physiology ; Functional Laterality ; Hand/physiology ; Humans ; Motor Skills/*physiology ; *Movement
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 27
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1979-09-07
    Beschreibung: A direct method has been employed to estimate the rate of production by human brain of 3-methoxy-4-hydroxyphenethyleneglycol, the major metabolite of brain norepinephrine, a brain neurotransmitter. Venous specimens were obtained from the internal jugular vein from ten awake human subjects at a puncture site above the common facial vein, the first major source of extracranial inflow. Arterial specimens were simultaneously obtained from the radial artery. Plasma samples were assayed and a highly significant difference was found in the concentration of the metabolite in plasma coming out of the brain (venous blood) as compared to plasma entering the brain (arterial blood). This venous-arterial difference was calculated to be 0.7 +/- 0.1 nanogram per milliliter of blood. Assuming an adult brain weight of 1400 grams and normal cerebral blood flow, it is estimated that the rate of production of 3-methoxy-4-hydroxyphenethyleneglycol by the awake human brain is approximately 597 nanograms per minute or 35.8 micrograms per hour. Urine specimens were also collected from six of these subjects during a period of 1 to 3.5 hours, which bracketed the time the blood samples were obtained. For these six subjects the output of 3-methyoxy-4-hydroxyphenethyleneglycol by whole brain was estimated to be 40.9 micrograms per hour, whereas the rate of its excretion into urine was 64.5 micrograms per hour.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maas, J W -- Hattox, S E -- Greene, N M -- Landis, D H -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1025-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472724" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Brain/*metabolism ; Cerebrovascular Circulation ; Female ; Glycols/*metabolism ; Humans ; Male ; Methoxyhydroxyphenylglycol/blood/*metabolism/urine ; Middle Aged ; Norepinephrine/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 28
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    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1979-10-05
    Beschreibung: Radioimmunoassay and chromatography analyses of hypothalamic luteinizing hormone-releasing hormone (LHRH) have demonstrated the presence of LHRH-like immunoreactive peptides in a wide range of vertebrates. Contrary to previous reports, the molecule differs in various vertebrates. Avian, reptilian, and teleostean LHRH's are chemically distinct from the mammalian peptide but are in themselves indistinguishable. However, amphibian LHRH appears to be identical to the mammalian peptide. These findings have interesting evolutionary implications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉King, J A -- Millar, R P -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):67-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/384514" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Biological Evolution ; Chromatography ; Gonadotropin-Releasing Hormone/*analysis/immunology ; Hypothalamus/analysis ; Radioimmunoassay ; Species Specificity ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 29
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1979-07-13
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):177-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451586" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Female ; Humans ; Mass Screening/*economics ; Middle Aged ; *Papanicolaou Test ; Risk ; Socioeconomic Factors ; Uterine Cervical Neoplasms/epidemiology/*prevention & control ; Vaginal Smears/*economics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 30
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    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1979-09-14
    Beschreibung: Single-dose administration of pergolide mesylate (100 to 400 micrograms) results in a dose-related inhibition of prolactin secretion which persists for more than 24 hours. During multiple-dose administration of pergolide, plasma prolactin concentrations remain markedly reduced (greater than 80 percnet) and gradually return to control levels several days after drug administration is discontinued.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lemberger, L -- Crabtree, R E -- New York, N.Y. -- Science. 1979 Sep 14;205(4411):1151-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/382359" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Clinical Trials as Topic ; Dose-Response Relationship, Drug ; Ergolines/*pharmacology/therapeutic use ; Humans ; Informed Consent ; Male ; Middle Aged ; Placebos ; Prolactin/blood ; Receptors, Dopamine/*drug effects ; Time Factors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 31
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1979-11-30
    Beschreibung: The tertiary structures of all liganded hemoglobins in the R state differ in detail. Steric hindrance arising from nonbonded ligand-globin interactions affects the binding of ligands such as CO and cyanide which preferentially form linear axial complexes to heme; these ligands bind in a strained off-axis configuration. Ligands such as O2 and NO, which preferentially form bent complexes, encounter less steric hindrance and can bind in their (preferred) unstrained configuration. Linear complexes distort the ligand pockets in the R state (and by inference, in the T state) more than bent complexes. These structural differences between linear and bent complexes are reflected in the kinetic behavior of hemoglobin. Structural interpretation of this kinetic behavior indicates that the relative contributions of nonbonded ligand-globin interactions and nonbonded heme interactions to transition state free energies differ for linear and bent ligands. The relative contributions of these interactions to the free energy of cooperativity may also differ for linear and bent ligands. Thus the detailed molecular mechanism by which the affinity of heme is regulated differs for different ligands.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moffat, K -- Deatherage, J F -- Seybert, D W -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1035-42.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493990" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Allosteric Regulation ; Animals ; Heme/*metabolism ; Hemoglobins/metabolism ; Horses ; Kinetics ; Ligands ; Oxygen/*metabolism ; Oxyhemoglobins/*metabolism ; Protein Conformation ; Stereoisomerism ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 32
    facet.materialart.
    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1979-01-05
    Beschreibung: An adenylate cyclase activated as much as 25-fold by low concentrations of octopamine has been identified in the firefly lantern. The relative potency of octopamine and various other amines in stimulating this enzyme, and effects of antagonists in blocking octopamine activation, correlate well with the known effects of these agents in affecting light production. In addition to suggesting a role for adenosine 3',5'-monophosphate (or pyrophosphate) in the neural control of firefly flashing, identification of this potent enzyme should facilitate the characterization of phenylethylamine receptors in excitable tissue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nathanson, J A -- New York, N.Y. -- Science. 1979 Jan 5;203(4375):65-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/214856" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenylyl Cyclases/*metabolism ; Animals ; Beetles/*physiology ; Catecholamines/pharmacology ; Cyclic AMP/*biosynthesis ; Dose-Response Relationship, Drug ; Enzyme Activation/drug effects ; Kinetics ; Octopamine/*pharmacology ; Phentolamine/pharmacology ; Propranolol/pharmacology ; Receptors, Cell Surface/*drug effects ; Receptors, Neurotransmitter/*drug effects ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 33
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    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1979-09-28
    Beschreibung: Subdivisions of the human peri-Sylvian language cortex were derived from stimulation mapping during craniotomies under local anesthesia. Naming, reading, short-term verbal memory, single and sequential orofacial movements, and phoneme identification were tested. Sequential orofacial movements and phoneme identification were altered from the same brain sites and thus identified a common system for language production and understanding. This system surrounded a final motor pathway for speech and was surrounded by a separate short-term verbal-memory system. Between the sequential motor-phoneme identification and memory systems were sites where only naming or reading were altered, including sites related exclusively by syntax.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ojemann, G -- Mateer, C -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1401-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472757" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Adult ; Brain Mapping ; Cerebral Cortex/*physiology ; Face ; Functional Laterality ; Humans ; Lip/physiology ; Memory/*physiology ; Movement ; Posture ; Speech/*physiology ; Speech Perception/*physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 34
    facet.materialart.
    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1979-01-05
    Beschreibung: Substitution of a methyl group for the N-terminal hydrogen of gramicidin greatly increased the rate of dissociation of conductive channels in lipid bilayer membranes. The finding of short lifetimes for conductive channels, comparable to those seen for the neuromuscular junction, lends support to the head-to-head dimer structure for the conductive channel.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Szabo, G -- Urry, D W -- New York, N.Y. -- Science. 1979 Jan 5;203(4375):55-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/83000" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cations, Monovalent ; Electric Conductivity ; *Gramicidin ; *Ion Channels ; Membranes, Artificial ; Models, Biological ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 35
    facet.materialart.
    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1979-11-30
    Beschreibung: Wild-type Chinese hamster V79 cells (6-thioguanine-sensitive) reduce the recovery of 6-thioguanine-resistant cells when they are cultured together at high densities, through a form of intercellular communication (metabolic cooperation). Cooperation is inhibited by 12-O-tetradecanoyl phorbol-13-acetate, rescuing the 6-thioguanine-resistant cells. These results may be useful in the study of an aspect of the mechanism of tumor promotion and in assaying for promoters.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yotti, L P -- Chang, C C -- Trosko, J E -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1089-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493994" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Communication/*drug effects ; Cell Membrane/drug effects ; Cricetinae ; Dose-Response Relationship, Drug ; Drug Resistance ; Phorbol Esters/*pharmacology ; Phorbols/*pharmacology ; Structure-Activity Relationship ; Tetradecanoylphorbol Acetate/pharmacology ; Thioguanine/pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 36
    Publikationsdatum: 1980-12-12
    Beschreibung: Two- to threefold variations in sleep length were observed in 12 subjects living on self-selected schedules in an environment free of time cues. The duration of polygraphically recorded sleep episodes was highly correlated with the circadian phase of the body temperature rhythm at bedtime and not with the length of prior wakefulness. Furthermore, the rate of REM (rapid eye movement) sleep accumulation , REM latency, bedtime selection, and self-rated alertness assessments were also correlated with the body temperature rhythm.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Czeisler, C A -- Weitzman, E d -- Moore-Ede, M C -- Zimmerman, J C -- Knauer, R S -- AG-00792/AG/NIA NIH HHS/ -- GM-07365/GM/NIGMS NIH HHS/ -- MH-28460/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1980 Dec 12;210(4475):1264-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7434029" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Body Temperature ; *Circadian Rhythm ; Humans ; Male ; Middle Aged ; Sleep/*physiology ; Sleep, REM/physiology ; Wakefulness
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 37
    Publikationsdatum: 1980-11-07
    Beschreibung: An analog of luteinizing hormone-releasing hormone containing a gamma-lactam as a conformational constraint has been prepared with the use of a novel cyclization of a methionine sulfonium salt. The analog is more active as a luteinizing hormone-releasing hormone agonist that the parent hormone, and provides evidence for a bioactive conformation containing a beta-turn.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Freidinger, R M -- Veber, D F -- Perlow, D S -- Brooks, J R -- Saperstein, R -- New York, N.Y. -- Science. 1980 Nov 7;210(4470):656-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7001627" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Animals ; Biological Assay ; Cells, Cultured ; Female ; *Gonadotropin-Releasing Hormone/analogs & derivatives ; Hydrogen Bonding ; Lactams ; Protein Conformation ; Rats ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 38
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1980-06-27
    Beschreibung: A discussion of drug-receptor theory is used to show that the three-dimensional structure, or shape, of molecules is important for biological activity. The computer-assisted molecular modeling system at Merck is described, and it is shown that this system is useful for generating and storing molecular structures, determining preferred conformation, comparing molecular shapes, and computing molecular properties. Applications of the system to the study of anti-inflammatory drugs, somatostatin-like compounds, and dihydrofolate reductase inhibitors are summarized.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gund, P -- Andose, J D -- Rhodes, J B -- Smith, G M -- New York, N.Y. -- Science. 1980 Jun 27;208(4451):1425-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6104357" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Arachidonic Acids ; Binding Sites ; Computers ; Cyclooxygenase Inhibitors ; Humans ; Indomethacin ; *Models, Molecular ; *Models, Structural ; *Molecular Conformation ; *Pharmaceutical Preparations ; Receptors, Drug/metabolism ; Somatostatin/analogs & derivatives ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 39
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    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1980-03-21
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1980 Mar 21;207(4437):1323-5, 1327-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7188816" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Environment ; Female ; Genetics, Medical ; Humans ; Intelligence ; Male ; Pregnancy ; Twins/*psychology ; Twins, Monozygotic/*psychology
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    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 40
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1980-05-09
    Beschreibung: Olfactory sensitivity to acetic acid, isobutyric acid, and 2-sec-butyl-cyclohexanone was tested in 97 adult male twin pairs to determine the extent to which variation in odor perception was genetically determined. Analysis of the data revealed no evidence for heritability of olfactory sensitivity. However, factors significantly associated with odor perception included cigar, pipe, and cigarette smoking; body fatness; alcohol consumption; and diabetes mellitus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hubert, H B -- Fabsitz, R R -- Feinleib, M -- Brown, K S -- New York, N.Y. -- Science. 1980 May 9;208(4444):607-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7189296" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acetates ; Adult ; Alcohol Drinking ; Butyrates ; Cyclohexanones ; *Environment ; Female ; *Genes ; Humans ; Male ; Middle Aged ; Pregnancy ; Sensory Thresholds ; Skinfold Thickness ; Smell/*physiology ; Smoking ; *Twins ; Twins, Dizygotic ; Twins, Monozygotic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 41
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1980-07-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):475-6, 478-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7394512" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Anorexia Nervosa ; Female ; *Human Experimentation ; Humans ; *Jurisprudence ; Lithium ; *National Institutes of Health (U.S.) ; *Patient Selection ; *Research ; *Research Subjects ; Sleep ; United States ; Vomiting
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 42
    Publikationsdatum: 1980-01-18
    Beschreibung: When unilamellar vesicles were administered subcutaneously in mice, the half-time for the destruction of the vesicles varied from 12 to 600 hours, depending on their composition. The vesicles tested consisted of distearoyl phosphatidylcholine, cholesterol, and certain sugar and amino-sugar derivatives of cholesterol. Vesicle with amino-sugar derivatives showed the greatest longevity and became localized with high specificity in aggregates of polymorphonuclear leukocytes. A substantial delay between the time that the vesicles broke open and the time that labels contained in the vesicles were excreted suggests that the vesicles undergo endocytosis before destruction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mauk, M R -- Gamble, R C -- Baldeschwieler, J D -- New York, N.Y. -- Science. 1980 Jan 18;207(4428):309-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7350660" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cholesterol/analogs & derivatives ; Endocytosis ; Liposomes/*therapeutic use ; Lysosomes/metabolism ; Metabolic Clearance Rate ; Mice ; Neutrophils/*metabolism ; Phosphatidylcholines ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 43
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1980-02-08
    Beschreibung: Heroin-dependent men were given buprenorphine (a partial opiate agonist-antagonist) or a placebo under duoble-blind conditions on a clinical research ward where they could acquire heroin (21 to 40.5 milligrams per day, intravenously). Buprenorphine significantly (P less than .001) suppressed the self-administration of heroin over 10 days. Control subjects took between 93 and 100 percent of the available heroin. The effects of buprenorphine were dose-dependent; a dose of 8 milligrams per day reduced heroin use by 69 to 98 percent; a dose of 4 milligrams per day reduced heroin use by 45 percent. Termination of buprenorphie maintenance did not result in opiate withdrawal signs or symptoms. The subjects liked buprenorphine and indicated that it was preferable to methadone or naltrexone. Buprenorphine should be a safe and effective new pharmacotherapy for heroin dependence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mello, N K -- Mendelson, J H -- New York, N.Y. -- Science. 1980 Feb 8;207(4431):657-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7352279" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Buprenorphine/adverse effects/*therapeutic use ; Double-Blind Method ; Heroin Dependence/*drug therapy ; Humans ; Informed Consent ; Morphinans/*therapeutic use ; Substance Withdrawal Syndrome/prevention & control ; Substance-Related Disorders/prevention & control
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 44
    Publikationsdatum: 1980-04-25
    Beschreibung: A high incidence of tumor regression was observed in guinea pigs bearing transplantable, line-10 hepatocellular carcinomas when synthetic muramyl dipeptides combined with trehalose dimycolate in oil-in-water emulsions were injected directly into the tumors. These compounds are promising candidates to replace viable bacillus Calmette-Guerin in cancer immunotherapy in humans and animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McLaughlin, C A -- Schwartzman, S M -- Horner, B L -- Jones, G H -- Moffatt, J G -- Nestor, J J Jr -- Tegg, D -- New York, N.Y. -- Science. 1980 Apr 25;208(4442):415-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7189295" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acetylmuramyl-Alanyl-Isoglutamine/administration & dosage/*therapeutic use ; Animals ; Cord Factors/administration & dosage/*therapeutic use ; Drug Combinations ; Emulsions ; Glycolipids/*therapeutic use ; Glycopeptides/*therapeutic use ; Immunotherapy ; Liver Neoplasms, Experimental/*therapy ; Lymphatic Metastasis ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 45
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    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1980-12-05
    Beschreibung: The lead content in the air at the foothills of the Himalayas in Nepal was found to be negligible. The concentration of lead in the blood of 103 children and adults living in this region was found to average 3.4 micrograms per deciliter, a level substantially lower than that found in industrialized populations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Piomelli, S -- Corash, L -- Corash, M B -- Seaman, C -- Mushak, P -- Glover, B -- Padgett, R -- ES-01104/ES/NIEHS NIH HHS/ -- ES-26437/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 1980 Dec 5;210(4474):1135-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7444442" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Air Pollutants/*analysis ; Child, Preschool ; China ; Environment ; Female ; Humans ; *Industry ; Lead/*blood ; Male ; Nepal
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 46
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1980-11-07
    Beschreibung: A stereospecific binding site for nicotine has been detected on rat brain membranes. Competition studies with cholinergic agonists suggest that this site is a nicotinic cholinergic receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Romano, C -- Goldstein, A -- DA-1938/DA/NIDA NIH HHS/ -- DA-7063/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1980 Nov 7;210(4470):647-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7433991" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Binding, Competitive ; Brain/*metabolism ; Ligands ; Male ; Nicotine/metabolism ; Rats ; Receptors, Cholinergic/*metabolism ; Receptors, Nicotinic/*metabolism ; Stereoisomerism ; Structure-Activity Relationship ; Synaptic Membranes/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 47
    facet.materialart.
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1980-06-13
    Beschreibung: Teacher interactions with hyperactive and comparison boys were observed during classroom activities. A double-blind, methylphenidate-placebo cross-over design was used within the hyperactive group. With no knowledge of any child's diagnosis or drug status, the teacher was more intense and controlling toward hyperactive boys taking placebo than toward either medicated hyperactive boys or comparison boys; her behavior did not differ toward the latter two groups. Discussion focused on the need to consider the broad social ramifications of pharmacologic treatment programs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Whalen, C K -- Henker, B -- Dotemoto, S -- New York, N.Y. -- Science. 1980 Jun 13;208(4449):1280-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7375940" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Behavior/drug effects ; Child ; Humans ; Hyperkinesis/*drug therapy ; *Interpersonal Relations ; Male ; Methylphenidate/pharmacology/*therapeutic use ; *Teaching
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 48
    facet.materialart.
    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1980-03-21
    Beschreibung: Phonemically similar syllables, differing only by temporal acoustic cues, were presented dichotically to investigate temporal processing mechanisms in hemispheric specialization for speech. Reducing the rate of acoustic change within syllables while keeping their phonemic characteristics constant significantly decreased the characteristic asymmetry in processing speech.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwartz, J -- Tallal, P -- New York, N.Y. -- Science. 1980 Mar 21;207(4437):1380-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7355297" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Auditory Pathways/physiology ; Auditory Perception/*physiology ; Brain/*physiology ; Female ; *Functional Laterality ; Humans ; Linguistics ; Male ; Speech Perception/*physiology ; Time Factors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 49
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1980-09-12
    Beschreibung: The ability to see spatial structures of a wide range of sizes was measured for two groups of observers (mean ages, 18 and 73 years). All observers had good visual acuity. Although older and younger observers did not differ in ability to see targets with fine structure (high spatial frequencies), older observers were only one-third as sensitive to targets with coarse structure (low spatial frequencies) as were younger observers or to changes in criterion. Older observers were also less able than younger observers to see moving targets. The reduced sensitivity of the older observers may adversely affect routine perceptual activities, such as face recognition and visually guided postural behavior, that depend upon low spatial frequencies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sekuler, R -- Hutman, L P -- Owsley, C J -- New York, N.Y. -- Science. 1980 Sep 12;209(4462):1255-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7403884" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Aged ; *Aging ; Humans ; Motion Perception/physiology ; Size Perception/*physiology ; Space Perception/*physiology ; Visual Acuity
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 50
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1981-04-17
    Beschreibung: Voltage-clamp recordings from mouse spinal neurons grown in culture were used to study the membrane current fluctuations induced by 12 substances structurally similar to gamma-aminobutyric acid (GABA). Fluctuation analysis provided estimates of the electrical properties of the elementary events underlying these responses. Estimates of the mean conductance of channels activated by all of the substances except glycine did not differ significantly from that estimated for GABA, whereas mean durations of agonist-activated channels all differed significantly from that found for GABA. The results indicate that all of the substances tested except glycine activate channels of similar conductance but of different durations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barker, J L -- Mathers, D A -- New York, N.Y. -- Science. 1981 Apr 17;212(4492):358-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6259733" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Membrane/drug effects ; Ion Channels/*drug effects ; Membrane Potentials/drug effects ; Mice ; Neurons/drug effects ; Receptors, Cell Surface/metabolism ; Receptors, GABA-A ; Spinal Nerves/*drug effects ; Structure-Activity Relationship ; Time Factors ; gamma-Aminobutyric Acid/*analogs & derivatives/pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 51
    Publikationsdatum: 1981-08-21
    Beschreibung: A new technique has been developed for identifying, in humans, dynamic spatiotemporal electrical patterns of the brain during purposive behaviors. In this method, single-trial time-series correlations between brain macropotentials recorded from different scalp sites are analyzed by distribution-independent mathematical pattern recognition. Dynamic patterns of correlation clearly distinguished two brief visuomotor tasks differing only in type of mental judgement required (spatial or numeric). These complex patterns shifted in the anterior-posterior and left-right axes between successive 175-millisecond intervals, indicating that many areas in both cerebral hemispheres were involved even in these simple judgements. These patterns were not obtainable by conventional analysis of averaged evoked potentials or by linear analysis of correlations, suggesting that the new technique will advance the study of human brain activity related to cognition and goal-directed behaviors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gevins, A S -- Doyle, J C -- Cutillo, B A -- Schaffer, R E -- Tannehill, R S -- Ghannam, J H -- Gilcrease, V A -- Yeager, C L -- New York, N.Y. -- Science. 1981 Aug 21;213(4510):918-22.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256287" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Brain/*physiology ; *Cognition ; Electroencephalography ; *Evoked Potentials ; Female ; Humans ; Male ; Pattern Recognition, Visual/physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 52
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1981-03-20
    Beschreibung: Gender identity depends largely on postnatal environmental influences, while sex-dimorphic behavior and temperamental sex differences appear to be modified by prenatal sex hormones. A role of the prenatal endocrine milieu in the development of erotic partner preference, as in hetero-, homo-, or bisexual orientation, or of cognitive sex differences has not been conclusively demonstrated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ehrhardt, A A -- Meyer-Bahlburg, H F -- New York, N.Y. -- Science. 1981 Mar 20;211(4488):1312-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209510" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Adrenal Hyperplasia, Congenital/metabolism/psychology ; Adult ; Androgens/pharmacology ; Behavior/drug effects ; Child ; Cognition/drug effects ; Embryo, Mammalian/drug effects ; Estrogens/pharmacology ; Female ; *Gender Identity ; Gonadal Steroid Hormones/*pharmacology ; Humans ; *Identification (Psychology) ; Male ; Pregnancy ; Pregnancy Complications/drug therapy ; Progestins/pharmacology/therapeutic use ; Sexual Behavior/*drug effects
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 53
    Publikationsdatum: 1981-09-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldberg, E -- Antin, S P -- Bilder, R M Jr -- Gerstman, L J -- Hughes, J E -- Mattis, S -- New York, N.Y. -- Science. 1981 Sep 18;213(4514):1392-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7268442" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Amnesia/etiology/*physiopathology ; Amnesia, Retrograde/physiopathology ; Humans ; Male ; Memory/*physiology ; Mesencephalon/injuries/*physiopathology ; Skull Fractures/complications
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 54
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1981-10-23
    Beschreibung: The addition of ethanol or other aliphatic alcohols to rat brain membranes strongly inhibits binding of enkephalins at concentrations at which little inhibition of opiate alkaloids is seen. Inhibition is reversible, and potency increases with chain length of the alcohol. The results suggest that delta receptors are considerably more sensitive to alcohols than mu receptors. This is the first demonstration of selective inhibition of one of the postulated classes of opiate receptors by a reagent that is not a ligand for the receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hiller, J M -- Angel, L M -- Simon, E J -- DA-00017/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1981 Oct 23;214(4519):468-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6270788" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alcohols/*pharmacology ; Animals ; Brain/metabolism ; Cells, Cultured ; In Vitro Techniques ; Neuroblastoma/metabolism ; Rats ; Receptors, Opioid/classification/*drug effects/metabolism ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 55
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1981-02-27
    Beschreibung: A line or rat hepatoma cells in culture which, in response to serum starvation, become arrested in the early G1 phase of growth, can be stimulated by insulin alone to enter the cell cycle and traverse S phase. A half-maximum response is observed at 30 to 70 picomolar concentrations and the maximum response is essentially identical to that found with optimum serum concentrations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koontz, J W -- Iwahashi, M -- AM 24047/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Feb 27;211(4485):947-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7008195" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Cycle/drug effects ; Cell Division/drug effects ; Cell Line ; *Growth Substances ; Insulin/*pharmacology ; Liver Neoplasms, Experimental/*pathology ; Mitosis/drug effects ; Proinsulin/pharmacology ; Rats ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 56
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1981-08-14
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klotz, I M -- Haney, D N -- King, L C -- New York, N.Y. -- Science. 1981 Aug 14;213(4509):724-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256275" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Anemia, Sickle Cell/*drug therapy ; Aspirin/analogs & derivatives/therapeutic use ; Chemical Phenomena ; Chemistry ; *Hemoglobin, Sickle ; Humans ; Protein Binding/drug effects ; Protein Conformation ; Salicylates/*therapeutic use ; Solubility ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 57
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1981-09-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Light, W G -- New York, N.Y. -- Science. 1981 Sep 25;213(4515):1534.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7280676" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Asbestos ; Humans ; Occupational Diseases/chemically induced ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 58
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1981-09-04
    Beschreibung: Analogs of adenosine 3',5'-monophosphate (cyclic AMP) inhibit the growth of cultured cell lines. The effects of 8-bromo- and N6-butyryl-substituted analogs of cyclic and noncyclic AMP on six cell lines were examined and were equally inhibitory. Variant cell lines with altered cyclic AMP-dependent protein kinase were more resistant to both cyclic and noncyclic nucleotides. We conclude that growth inhibition by analogs of cyclic AMP (i) does not require a 3',5' phosphodiester bond and (ii) may be mediated by a pathway involving endogenous cyclic AMP.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Martin, T F -- Kowalchyk, J A -- AM 25861/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Sep 4;213(4512):1120-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6267695" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Division/*drug effects ; Cell Line ; Cricetinae ; Cyclic AMP/*pharmacology ; DNA/biosynthesis ; Growth Inhibitors/*pharmacology ; Mice ; Phosphodiesterase Inhibitors/pharmacology ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 59
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1981-11-27
    Beschreibung: Ten patients with multiple sclerosis who were treated with human fibroblast interferon (IFN-B) for 6 months showed a significant reduction in their exacerbation rates compared with their rates before treatment (P 〈 .01). The IFN-B was administered intrathecally by serial lumbar punctures. There was no significant change in the exacerbation rates of ten multiple sclerosis control patients before and during the period of observation. The IFN-B recipients have now been on the study a mean of 1.5 years, the controls, 1.2 years. The clinical condition of five of the IFN-B recipients and one of the control patients has improved, whereas the condition of five of the controls and one of the IFN-B recipients has deteriorated (P 〈 .036). These findings warrant cautious optimism about the efficacy of intrathecal IFN-B in altering the course of multiple sclerosis and support concepts of a viral or dysimmune etiology of the disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jacobs, L -- O'Malley, J -- Freeman, A -- Ekes, R -- CA-18533/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Nov 27;214(4524):1026-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6171035" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Adult ; Clinical Trials as Topic ; Female ; Fibroblasts ; Follow-Up Studies ; Humans ; Interferons/*therapeutic use ; Male ; Multiple Sclerosis/*drug therapy
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 60
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1981-12-11
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1225-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302591" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Cephalosporins/therapeutic use ; Humans ; Research ; Structure-Activity Relationship ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 61
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1981-11-06
    Beschreibung: Partially purified thymosin fraction 5 and one of its synthetic peptide components, thymosin beta 4, but not thymosin alpha 1, stimulated secretion of luteinizing hormone--releasing factor from superfused medial basal hypothalami from random cycling female rats. In addition, luteinizing hormone was released from pituitary glands superfused in sequence with hypothalami. No release of luteinizing hormone in response to thymosin was observed from pituitaries superfused alone. These data provide the first evidence of a direct effect of the endocrine thymus on the hypothalamus and suggest a potentially important role for thymic peptides in reproductive function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rebar, R W -- Miyake, A -- Low, T L -- Goldstein, A L -- AG-01531/AG/NIA NIH HHS/ -- HD-12303/HD/NICHD NIH HHS/ -- HD-14362/HD/NICHD NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1981 Nov 6;214(4521):669-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7027442" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Gonadotropin-Releasing Hormone/*secretion ; Hormones/pharmacology ; Hypothalamo-Hypophyseal System/drug effects ; Hypothalamus/*drug effects ; Peptide Fragments/pharmacology ; Rats ; Structure-Activity Relationship ; Thymosin/*pharmacology ; Thymus Hormones/*pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 62
    Publikationsdatum: 1981-05-22
    Beschreibung: Extracts of samples of a Caribbean tunicate (ascidian, sea squirt) of the family Didemnidae inhibit in vitro at low concentrations the growth of DNA and RNA viruses as well as L1210 leukemic cells. The active compounds isolated from the tunicate, didemnins A, B, and C, are depsipeptides, and didemnin B (a derivative of didemnin A) is the component active at the lowest concentration in inhibiting viral replication in vitro and P388 leukemia in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rinehart, K L Jr -- Gloer, J B -- Hughes, R G Jr -- Renis, H E -- McGovren, J P -- Swynenberg, E B -- Stringfellow, D A -- Kuentzel, S L -- Li, L H -- AI 04769/AI/NIAID NIH HHS/ -- GM 27029/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1981 May 22;212(4497):933-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233187" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibiotics, Antineoplastic/*isolation & purification ; Antiviral Agents/*isolation & purification ; *Depsipeptides ; Leukemia, Experimental/*drug therapy ; Peptides, Cyclic/*isolation & purification/therapeutic use ; Structure-Activity Relationship ; Urochordata/*analysis
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 63
    Publikationsdatum: 1981-04-17
    Beschreibung: Sensory and cognitive functions were assessed in a right-handed male before and after partial and complete callosal commissurotomy. After the initial posterior section was made, there was no evidence of interhemispheric sensory transfer, although the left hemisphere did have access to stimulus-related semantic and episodic information from the right hemisphere. After the callosum was completely sectioned, this exchange was no longer observed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sidtis, J J -- Volpe, B T -- Holtzman, J D -- Wilson, D H -- Gazzaniga, M S -- 2 R01 NS15053-02/NS/NINDS NIH HHS/ -- RR001-02/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 17;212(4492):344-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6782673" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Cognition/*physiology ; Cognition Disorders/*physiopathology ; Corpus Callosum/*physiology/surgery ; Epilepsy, Tonic-Clonic/surgery ; Humans ; Language Disorders/*physiopathology ; Male ; Methods ; Perception/physiology ; Perceptual Disorders/*physiopathology ; Postoperative Complications/physiopathology ; Sensation/*physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 64
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1981-04-03
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, N -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):24-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6259731" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Adult ; *DNA, Recombinant ; *Ethics Committees, Research ; *Ethics, Medical ; Federal Government ; Female ; *Genetic Engineering/history ; Genetic Vectors ; Globins/genetics ; Government Regulation ; History, 20th Century ; Humans ; Informed Consent ; Israel ; Plasmids ; Thalassemia/*therapy ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 65
    Publikationsdatum: 1981-02-06
    Beschreibung: Arginine vasopressin and a number of its synthetic analogs augment memory functions in experimental animals. One of these analogs, 1-desamino-8-D-arginine vasopressin (DDAVP), influences human learning and memory. Cognitively unimpaired, as well as cognitively impaired adults, treated with DDAVP for a period of several days, learn information more effectively, as measured by the completeness, organization, and consistency (reliability) of recall. DDAVP also appears to reverse partially the retrograde amnesia that follows electroconvulsive treatment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weingartner, H -- Gold, P -- Ballenger, J C -- Smallberg, S A -- Summers, R -- Rubinow, D R -- Post, R M -- Goodwin, F K -- New York, N.Y. -- Science. 1981 Feb 6;211(4482):601-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7455701" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Arginine Vasopressin/*pharmacology ; Cognition/drug effects ; Deamino Arginine Vasopressin/pharmacology ; Depression/physiopathology ; Female ; Humans ; Learning/*drug effects ; Male ; Memory/*drug effects ; Middle Aged
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 66
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    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1981-05-08
    Beschreibung: The cumulative effects of a repetitive stress induced by anticipation of pain (noxious foot shock) were studied on the threshold of a nociceptive flexion reflex of the lower limb. The threshold of the nociceptive reflex progressively increased with the repetition of the stress. This effect was reversed by naloxone, which even produced hyperalgesia, since a rapid and significant decrease in this threshold, below the initial values, was noted. Tha data provide evidence for involvement of endogenous opioids in the phenomenon of stress-induced analgesia in normal man.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Willer, J C -- Dehen, H -- Cambier, J -- New York, N.Y. -- Science. 1981 May 8;212(4495):689-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6261330" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Female ; Humans ; Male ; Naloxone/pharmacology ; Pain/*physiopathology ; Receptors, Opioid/*physiology ; Reflex/drug effects ; Stress, Psychological/*physiopathology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 67
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    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1982-06-11
    Beschreibung: Receptors that selectively bind micromolar concentrations of benzodiazepines are present in rat brain membrane. These micromolar receptors exhibit saturable, stereospecific binding, and the potency of benzodiazepine binding to these receptors is correlated with the ability of the benzodiazepines to inhibit maximum electric shock-induced convulsions. Benzodiazepine receptors with nanomolar affinity differ from the micromolar receptors in their binding, kinetic, and pharmacologic characteristics. The micromolar receptors also bind phenytoin, a non-benzodiazepine anticonvulsant. These results provide evidence for a distinct class of clinically relevant benzodiazepine receptors that may regulate neuronal excitability and anticonvulsant activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bowling, A C -- DeLorenzo, R J -- NS 1352/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Jun 11;216(4551):1247-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6281893" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Benzodiazepines/*metabolism/pharmacology ; Benzodiazepinones/metabolism ; Brain/*metabolism ; Calmodulin/antagonists & inhibitors ; Diazepam/metabolism ; Kinetics ; Ligands ; Protein Kinase Inhibitors ; Rats ; Receptors, Drug/*metabolism ; Receptors, GABA-A ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 68
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1982-11-05
    Beschreibung: Simple chemical catalysts have been designed to achieve some desirable features of enzymes. These novel catalysts are not proteins, but they may incorporate the typical enzyme catalytic groups and they achieve selectivity in their reactions by use of geometric control, as do enzymes. Catalysts that carry out geometrically controlled chlorinations of aromatic rings and steroids have been constructed. Other catalysts achieve the selective synthesis of amino acids, and still others imitate ribonuclease in detailed mechanism and hydrolyze RNA. Optimization of geometries has led to a rate acceleration of over 10(8) in one instance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Breslow, R -- New York, N.Y. -- Science. 1982 Nov 5;218(4572):532-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123255" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Catalysis ; Cyclodextrins ; *Enzymes ; Kinetics ; Models, Chemical ; Ribonucleases ; Structure-Activity Relationship ; Substrate Specificity ; Transaminases
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 69
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1982-01-08
    Beschreibung: (+/-)-N-Allylnormetazocine is a benzomorphan opioid with psychotomimetic effects. The pure stereoisomers of this compound, as well as the racemic mixture, were compared to phencyclidine for their behavioral effects on squirrel monkeys and rats trained to discriminate phencyclidine from saline. Dose-response determinations were made for responses to phencyclidine, to a racemic mixture of N-allylnormetazocine, and to the pure levo and dextro isomers of N-allylnormetazocine. In both rats and monkeys, the dextro isomer and the racemic mixture produced dose-dependent responses appropriate for phencyclidine; the levo isomer did not produce the responses appropriate for phencyclidine at any of the doses tested. In both species, the levo isomer was more potent than the dextro isomer in decreasing the rate of responding. Thus racemic N-allylnormetazocine is a mixture of compounds that produce different behavioral effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brady, K T -- Balster, R L -- May, E L -- DA-00490/DA/NIDA NIH HHS/ -- DA-01442/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 8;215(4529):178-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6274022" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Behavior, Animal/*drug effects ; Male ; Naloxone/pharmacology ; Phenazocine/*analogs & derivatives/pharmacology ; Phencyclidine/pharmacology ; Rats ; Rats, Inbred Strains ; Receptors, Opioid/drug effects ; Saimiri ; Stereoisomerism ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 70
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    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1982-09-10
    Beschreibung: Alkyl-Substituted gamma-butyrolactones were synthesized and tested for their convulsant and anticonvulsant actions in mice and guinea pigs. The alpha-substituted compounds, alpha, alpha-dimethyl-, and alpha-ethyl-alpha-methyl-gamma-butyrolactone were anticonvulsant compounds with a spectrum of activity similar to that of ethosuximide. In contrast, beta-substituted compounds were convulsant agents similar to picrotoxinin. The alpha-substituted-gama-butyrolactones represent a new class of anticonvulsant drug with experimental and clinical potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klunk, W E -- McKeon, A -- Covey, D F -- Ferrendelli, J A -- GM-07200/GM/NIGMS NIH HHS/ -- GM-24483/GM/NIGMS NIH HHS/ -- NS-14834/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):1040-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6810462" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *4-Butyrolactone/analogs & derivatives/*therapeutic use/toxicity ; Animals ; *Anticonvulsants ; Chemical Phenomena ; Chemistry ; Convulsants ; Drug Evaluation, Preclinical ; Electroencephalography ; Epilepsy, Absence/drug therapy ; Ethosuximide/pharmacology ; *Furans/*therapeutic use ; Guinea Pigs ; Mice ; Structure-Activity Relationship ; Trimethadione/pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 71
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1982-12-24
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1982 Dec 24;218(4579):1295-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6183747" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Anemia, Sickle Cell/therapy ; Azacitidine/therapeutic use ; Fetal Hemoglobin/biosynthesis/*genetics ; Hemoglobin, Sickle/biosynthesis ; Humans ; Male ; Thalassemia/therapy
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    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 72
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    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1982-07-02
    Beschreibung: Inosine peripherally administered to rats markedly suppressed spontaneous food intake and food intake induced by diazepam, muscimol, insulin, and food deprivation. The purines 2-deoxyguanosine and 2-deoxyinosine also suppressed food deprivation-induced feeding, whereas 7-methylinosine, which does not bind to the benzodiazepine binding site in vitro, had no effect on food intake when compared with controls. These results suggest that purines may represent endogenous substances that regulate food intake through interactions with the benzodiazepine receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levine, A S -- Morley, J E -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):77-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7046046" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Appetite/*drug effects ; Deoxyguanosine/pharmacology ; Diazepam/pharmacology ; Eating/*drug effects ; Food Deprivation ; Inosine/analogs & derivatives/pharmacology ; Insulin/pharmacology ; Male ; Muscimol/pharmacology ; Purines/*pharmacology ; Rats ; Rats, Inbred Strains ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 73
    Publikationsdatum: 1982-05-28
    Beschreibung: The photosynthesis of previtamin D3 from 7-dehydrocholesterol in human skin was determined after exposure to narrow-band radiation or simulated solar radiation. The optimum wavelengths for the production of previtamin D3 were determined to be between 295 and 300 nanometers. When human skin was exposed to 295-nanometer radiation, up to 65 percent of the original 7-dehydrocholesterol content was converted to previtamin D3. In comparison, when adjacent skin was exposed to simulated solar radiation, the maximum formation of previtamin D3 was about 20 percent. Major differences in the formation of lumisterol3, and tachysterol3 from previtamin D3 were also observed. It is concluded that the spectral character of natural sunlight has a profound effect on the photochemistry of 7-dehydrocholesterol in human skin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉MacLaughlin, J A -- Anderson, R R -- Holick, M F -- AM 27334/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 May 28;216(4549):1001-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6281884" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cholecalciferol/*biosynthesis/metabolism ; Dehydrocholesterols/radiation effects ; Ergosterol/metabolism ; Humans ; In Vitro Techniques ; Isomerism ; Photochemistry ; Skin/*metabolism ; Spectrum Analysis ; Structure-Activity Relationship ; Ultraviolet Rays
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 74
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    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1982-05-07
    Beschreibung: Intracerebroventricular administration of oxytocin to virgin female rats that had been ovariectomized and primed with estrogen 48 hours previously induced a rapid onset of full maternal behavior. The maternal behavior persisted and its incidence was dose-related. Tocinoic acid, the ring structure of oxytocin, also rapidly induced the onset of persistent, full maternal behavior. Arginine vasopressin induced persistent maternal behavior, but this behavior had a later onset. Prostaglandin F2 alpha induced strong partial maternal behavior, which showed early onset but did not persist. Many other peptides, ovarian steroids, and prostaglandin E2 were no more effective than saline. These findings suggest that the release of oxytocin and prostaglandin F2 alpha during labor may promote maternal behavior in rats.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pedersen, C A -- Ascher, J A -- Monroe, Y L -- Prange, A J Jr -- MH-22536/MH/NIMH NIH HHS/ -- MH-32316/MH/NIMH NIH HHS/ -- MH-34933/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1982 May 7;216(4546):648-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7071605" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Arginine Vasopressin/pharmacology ; Brain/physiology ; Female ; Injections, Intraventricular ; *Maternal Behavior ; Oxytocin/administration & dosage/*pharmacology ; Rats ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 75
    Publikationsdatum: 1982-11-26
    Beschreibung: The timing of two event-related potential components was differentially affected by two experimental variables. The earlier component (NA) was affected by degradation of the stimuli and the later component (N2) by the nature of a classification task. The results support the hypothesis that NA and N2 reflect sequential stages of information processing, namely, pattern recognition and stimulus classification.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ritter, W -- Simson, R -- Vaughan, H G Jr -- Macht, M -- HD 10804/HD/NICHD NIH HHS/ -- IF32 AGO-5193/AG/NIA NIH HHS/ -- MH 06723/MH/NIMH NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Nov 26;218(4575):909-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7134983" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Action Potentials ; Adult ; Brain/*physiology ; Brain Mapping ; Cognition/*physiology ; Discrimination (Psychology)/physiology ; Evoked Potentials ; Humans ; Information Theory ; Perception/*physiology ; Time Factors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 76
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    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1982-09-03
    Beschreibung: Increases with aging in subperiosteal dimensions and second moments of area (measures of bending and torsional rigidity) in femoral and tibial cross sections are documented in an archeological sample from the American Southwest. Significant differences between cross-sectional sites and between sexes in the pattern of cortical remodeling with age are also present. These differences appear to be related to variations in the stress or strain levels in different regions of the femur and tibia which result from in vivo mechanical loadings of the lower limb.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ruff, C B -- Hayes, W C -- AM00749/AM/NIADDK NIH HHS/ -- AM26740/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Sep 3;217(4563):945-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7112107" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; *Aging ; Bone Development ; Female ; Femur/*physiology ; Fractures, Bone/etiology ; Growth ; Humans ; Male ; Middle Aged ; Periosteum/*physiology ; Physical Exertion ; Sex Characteristics ; Stress, Mechanical ; Tibia/*physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 77
    Publikationsdatum: 1982-01-08
    Beschreibung: Prompt and long-term closure of full-thickness skin wounds is guinea pigs and humans is achieved by applying a bilayer polymeric membrane. The membrane comprises a top layer of a silicone elastomer and a bottom layer of a porous cross-linked network of collagen and glycosaminoglycan. The bottom layer can be seeded with a small number of autologous basal cells before grafting. No immunosuppression is used and infection, exudation, and rejection are absent. Host tissue utilizes the sterile membrane as a culture medium to synthesize neoepidermal and neodermal tissue. A functional extension of skin over the entire wound area is formed in about 4 weeks.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yannas, I V -- Burke, J F -- Orgill, D P -- Skrabut, E M -- GM 21700/GM/NIGMS NIH HHS/ -- GM 23946/GM/NIGMS NIH HHS/ -- HL 14322/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 8;215(4529):174-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7031899" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Adult ; Animals ; Burns/*therapy ; Cells, Cultured ; Child ; Child, Preschool ; Collagen/therapeutic use ; Female ; Glycosaminoglycans/therapeutic use ; Guinea Pigs ; Humans ; Male ; Middle Aged ; Silicone Elastomers/therapeutic use ; *Skin Transplantation ; *Wound Healing
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 78
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1982-11-12
    Beschreibung: Transfer RNA's are probably very strongly selected for translational efficiency. In this article, the argument is presented that the coding performance of the triplet anticodon is enhanced by selection of a matching anticodon loop and stem sequence. the anticodon plus these nearby sequence features (the extended anticodon) therefore contains more coding information than the anticodon alone and can perform more efficiently and accurately at the ribosome. This idea successfully accounts for the relative efficiencies of many transfer RNA's.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yarus, M -- New York, N.Y. -- Science. 1982 Nov 12;218(4573):646-52.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6753149" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Base Sequence ; Escherichia coli/genetics ; Kinetics ; Nucleic Acid Conformation ; *Protein Biosynthesis ; RNA, Transfer/*genetics ; Ribosomes/metabolism ; Structure-Activity Relationship ; Suppression, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 79
    facet.materialart.
    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1983-10-07
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉HD-12572/HD/NICHD NIH HHS/ -- MH-00318/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 Oct 7;222(4619):74-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623059" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Age Factors ; Child, Preschool ; *Eye Movements ; Humans ; Research Design
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 80
    Publikationsdatum: 1983-05-20
    Beschreibung: The acquired immune deficiency syndrome (AIDS) is characterized by T-lymphocyte dysfunction and is frequently accompanied by opportunistic infections and Kaposi's sarcoma. Human T-cell leukemia virus (HTLV) is associated with T-cell malignancies and can transform T lymphocytes in vitro. In an attempt to find evidence of HTLV infection in patients with AIDS, DNA from samples of peripheral blood lymphocytes from 33 AIDS patients was analyzed by Southern blot-hybridization with a radiolabeled cloned HTLV DNA probe. Analysis of DNA from both the fresh (uncultured) lymphocytes and from T cells cultured with T-cell growth factor revealed the presence of integrated HTLV proviral sequences in lymphocytes from two of the patients, both of whom had antibody to HTLV. The proviral sequences could not be detected in blood samples obtained from these individuals at a later date, consistent with the possibility that the population of infected cells had become depleted.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gelmann, E P -- Popovic, M -- Blayney, D -- Masur, H -- Sidhu, G -- Stahl, R E -- Gallo, R C -- New York, N.Y. -- Science. 1983 May 20;220(4599):862-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6601822" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/etiology/immunology/*microbiology ; Adult ; Animals ; Cats ; DNA, Viral/*analysis ; Humans ; Male ; Middle Aged ; *Retroviridae/genetics ; T-Lymphocytes/analysis/microbiology ; Tumor Virus Infections/complications/*microbiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 81
    facet.materialart.
    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1983-06-03
    Beschreibung: The eye movements of human subjects were experimentally modified while they were awake to determine the effect of waking experience on electroculographic activity during rapid eye movement (REM) sleep. After normal eye movements were monitored under controlled conditions, subjects spent 5 days wearing goggles that contained minification lenses and that curtailed vision to a 5 degree field. The amplitude and frequency of eye movements decreased when subjects were awake and increased during REM sleep; sleep stage durations and distributions were unaffected. Values returned to normal in the first 24 hours of recovery.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Herman, J H -- Roffwarg, H P -- MH 3414/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 3;220(4601):1074-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6844929" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Electrooculography ; *Eye Movements ; Humans ; Oculomotor Muscles/physiology ; Sleep, REM/*physiology ; Wakefulness/*physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 82
    facet.materialart.
    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1983-04-01
    Beschreibung: The tissue culture condition that is required for the type of chromosome breakage seen at most fragile sites, namely, the absence of folic acid and thymidine in the medium, greatly enhanced micronucleus formation in proliferating lymphocyte cultures from normal individuals. This suggests that chromosome breakage at fragile sites and the apparently spontaneous damage that gives rise to micronuclei are controlled by the same mechanism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jacky, P B -- Beek, B -- Sutherland, G R -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):69-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828880" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Adult ; Cell Nucleus/drug effects/ultrastructure ; Cells, Cultured ; Child ; *Chromosome Aberrations ; Chromosome Fragile Sites ; *Chromosome Fragility ; Culture Media ; Dose-Response Relationship, Drug ; Female ; Folic Acid/pharmacology ; Humans ; Lymphocytes/ultrastructure ; Male ; Middle Aged ; Thymidine/pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 83
    facet.materialart.
    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1983-04-15
    Beschreibung: Glucose given to the newborn human may result in hyperglycemia, suggesting that its utilization is impaired at this developmental stage. Galactose is thought to be a more appropriate carbohydrate source for the newborn. The enzymes involved in hexose phosphorylation may, in part, be responsible for these observations. A key regulatory enzyme of hepatic glucose assimilation, glucokinase, is diminished in newborns compared to adults, whereas galactokinase activity is increased. When newborn dogs were fasted and then fed either glucose or galactose, their plasma insulin responses to glucose were similar, but the pups fed galactose demonstrated an attenuated systemic appearance rate of glucose. Hexose incorporation into hepatic glycogen and net glycogen synthesis was augmented in the galactose-fed dogs. In vitro, liver from neonatal dogs showed enhanced galactokinase activity relative to that for hexokinase or glucokinase. Neonatal hexose assimilation may be independent of insulin action and, instead, be related to the developmental presence of hexose phosphorylating enzymes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kliegman, R M -- Miettinen, E L -- Morton, S -- HD05740/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):302-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836273" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Animals ; Animals, Newborn/metabolism ; *Carbohydrate Metabolism ; Dogs ; Galactokinase/*physiology ; Galactose/metabolism ; Galactosemias ; Glucose/metabolism ; Humans ; Infant, Newborn ; Liver/enzymology ; Liver Glycogen/biosynthesis ; Phosphorylation ; Rats
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 84
    facet.materialart.
    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1983-11-04
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1983 Nov 4;222(4623):495-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623088" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Dna ; Eukaryota/genetics ; Humans ; *Nucleic Acid Conformation ; Species Specificity ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 85
    Publikationsdatum: 1983-08-26
    Beschreibung: A substitution of alanine for valine at position 126 in the beta-chain of hemoglobin was discovered in a hematologically normal adult male of Lebanese extraction. The variant beta-globin was initially observed and subsequently purified by reverse-phase high-performance liquid chromatography (HPLC). Reverse-phase HPLC was also used to isolate the variant tryptic peptide of beta-T13 that has alanine replacing valine at residue 126. The discovery of hemoglobin Beirut illustrates the usefulness of reverse-phase HPLC for the detection of neutral amino acid substitutions in proteins. The ability to detect neutral substitutions in undigested proteins is pertinent to the monitoring of genetic variation in human populations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Strahler, J R -- Rosenbloom, B B -- Hanash, S M -- R01-HL25541/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 26;221(4613):860-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879181" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Chromatography, High Pressure Liquid ; Hemoglobins, Abnormal/genetics/*isolation & purification ; Humans ; Isoelectric Point ; Macromolecular Substances ; Male
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 86
    facet.materialart.
    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1983-02-11
    Beschreibung: Contrary to previous predictions, relatively short synthetic peptides that mimic part of a protein sequence are routinely capable of eliciting an antiserum that reacts with the partially mimicked protein. Peptides capable of eliciting protein-reactive serums are frequently represented in the primary sequence of a protein, can be characterized by a set of simple chemical rules, and are confined neither to immunodominant regions of intact proteins nor to the amino or carboxyl terminals. As such, synthetic peptide immunogens are valuable for eliciting reagents with predetermined specificity that can be used for basic research. In addition, some synthetic peptides are capable of mimicking regions of virus proteins and eliciting immune responses in animals that are protective against the viral agents. Such peptides may thus serve as the basis for safe, chemically defined synthetic vaccines.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sutcliffe, J G -- Shinnick, T M -- Green, N -- Lerner, R A -- R01 AI 18509/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1983 Feb 11;219(4585):660-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6186024" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Antibody Specificity ; Cross Reactions ; *Epitopes ; Peptides/immunology ; Proteins/*immunology ; Structure-Activity Relationship ; Vaccines/immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 87
    Publikationsdatum: 1983-11-18
    Beschreibung: Hybridoma technology has made it possible to introduce into continuous culture normal antibody-forming cells and to obtain large amounts of the immunoglobulin produced by each of these cells. Examination of the structure of a number of monoclonal antibodies that react with a single antigen has provided new information on the structural basis of the specificity and affinity of antibodies. Comparisons of families of monoclonal antibodies derived from a single germ line gene revealed the importance of somatic mutation in generating antibody diversity. Monoclonal antibodies that react with variable regions of other monoclonals allow the further dissection and modulation of the immune response. Finally, the continued somatic instability of immunoglobulin genes in cultured antibody-forming cells makes it possible to determine the rate of somatic mutation and to generate mutant monoclonal antibodies that may be more effective serological reagents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Teillaud, J L -- Desaymard, C -- Giusti, A M -- Haseltine, B -- Pollock, R R -- Yelton, D E -- Zack, D J -- Scharff, M D -- 5T32GM7288/GM/NIGMS NIH HHS/ -- AI05231/AI/NIAID NIH HHS/ -- AI10702/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1983 Nov 18;222(4625):721-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6356353" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Animals ; Antibodies, Monoclonal/genetics/*immunology ; *Antibody Diversity ; Antibody Specificity ; Genes ; Hybridomas/immunology ; Immunoglobulin Idiotypes/immunology ; Immunoglobulin Variable Region/genetics ; Mice ; Mutation ; Protein Conformation ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 88
    facet.materialart.
    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1983-10-28
    Beschreibung: Morphological abnormalities including extra compound eyes, extra heads, and distally duplicated legs were generated in cricket embryos by treating eggs with single doses of either benz[g]isoquinoline-5,10-dione or benzo[h]quinoline-5,6-dione. Slight structural modifications of the molecules resulted in a loss of teratogenic activity, although embryotoxicity occurred. These potent insect teratogens can be used for analysis of developmental events during embryogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walton, B T -- Ho, C -- Ma, C Y -- O'Neill, E G -- Kao, G L -- New York, N.Y. -- Science. 1983 Oct 28;222(4622):422-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623081" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Isoquinolines/*toxicity ; Orthoptera/*embryology ; Quinolines/*toxicity ; *Quinolones ; Structure-Activity Relationship ; *Teratogens
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    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 89
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    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1983-07-29
    Beschreibung: Subjects treated with low or high doses of ethanol demonstrated impaired memory, particularly in tests involving the recall of poorly learned information. Zimelidine, an inhibitor of serotonin reuptake, reversed this ethanol-induced impairment. The serotonin neurotransmitter system may mediate learning and memory in humans and may determine some of the effects of alcohol on higher mental functions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weingartner, H -- Rudorfer, M V -- Buchsbaum, M S -- Linnoila, M -- New York, N.Y. -- Science. 1983 Jul 29;221(4609):472-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6223371" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Brompheniramine/analogs & derivatives/pharmacology ; Ethanol/*adverse effects ; Humans ; Learning/drug effects ; Male ; Memory/drug effects ; Memory Disorders/*chemically induced ; Mental Recall/drug effects ; Serotonin/*physiology ; Serotonin Antagonists/pharmacology ; Zimeldine
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 90
    Publikationsdatum: 1984-04-27
    Beschreibung: Hydroxylated derivatives of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a nigrostriatal neurotoxin in humans and primates, noncompetitively inhibited dihydropteridine reductase from human liver and rat striatal synaptosomes in vitro at micromolar concentrations. In contrast, MPTP and its chloro- and norderivatives did not inhibit this enzyme at lower than millimolar concentrations. Dihydropteridine reductase converts dihydrobiopterin to tetrahydrobiopterin, the required cofactor for the hydroxylation of aromatic amino acids during the synthesis of dopamine and serotonin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abell, C W -- Shen, R S -- Gessner, W -- Brossi, A -- HD 14635/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1984 Apr 27;224(4647):405-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6608790" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine ; Animals ; Corpus Striatum/enzymology ; Dihydropteridine Reductase/*antagonists & inhibitors ; Humans ; Hydroxylation ; Liver/enzymology ; NAD/metabolism ; NADH, NADPH Oxidoreductases/*antagonists & inhibitors ; Pyridines/*pharmacology ; Rats ; Structure-Activity Relationship ; Synaptosomes/enzymology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 91
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    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1984-09-28
    Beschreibung: Recent neurophysiological findings have demonstrated that abstinent chronic alcoholics manifest deficits in event-related brain potentials. To explore possible biological antecedents of alcoholism the present study examined boys at high risk for alcoholism. Event-related brain potentials were recorded from biological sons of alcoholic fathers and matched control boys. Differences in the P3 component of the potentials were obtained between the high-risk and control subjects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Begleiter, H -- Porjesz, B -- Bihari, B -- Kissin, B -- AA 05524/AA/NIAAA NIH HHS/ -- New York, N.Y. -- Science. 1984 Sep 28;225(4669):1493-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6474187" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Adult ; Alcoholism/*genetics/physiopathology ; Analysis of Variance ; Brain/*physiopathology ; Child ; Evoked Potentials ; Fathers ; Humans ; Male ; Memory Disorders/etiology ; Risk
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 92
    facet.materialart.
    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1983-06-10
    Beschreibung: The compound 2-phenylethylamine is an "endogenous amphetamine" which may modulate central adrenergic functions. 2-Phenylethylamine is mainly metabolized by monoamine oxidase to form phenyl acetate (PAA). The 24-hour urinary excretion of PAA was measured in normal healthy volunteers and depressed patients. Patients were diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, edition 3. In 70 percent of healthy volunteers of both sexes, the excretion of PAA ranged between 70 and 175 milligrams per 24 hours (mean = 141.1 +/- 10.2). Inpatients with major depressive disorder (unipolar type) (N = 31) excreted less PAA (68.7 +/- 7.0 milligrams per 24 hours) and 55 percent of them excreted less than 70 milligrams per 24 hours; there were no significant differences in the PAA excretion between untreated patients (N = 13) and those treated with antidepressants that were not effective (N = 18). The PAA excretion was reduced to a lesser extent in 35 less severely depressed unipolar outpatients (drug-free for 1 week) (86.3 +/- 11.8 milligrams per 24 hours). These results suggest that low PAA urinary excretion may be a reliable state marker for the diagnosis of some forms of unipolar major depressive disorders.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sabelli, H C -- Fawcett, J -- Gusovsky, F -- Javaid, J -- Edwards, J -- Jeffriess, H -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1187-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857245" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Adult ; Aged ; Antidepressive Agents/pharmacology ; Depressive Disorder/*diagnosis/urine ; Female ; Humans ; Male ; Middle Aged ; Phenethylamines/metabolism/physiology ; Phenylacetates/*urine
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 93
    facet.materialart.
    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1983-07-01
    Beschreibung: Although official efforts to control air pollution have traditionally focused on outdoor air, it is now apparent that elevated contaminant concentrations are common inside some private and public buildings. Concerns about potential public health problems due to indoor air pollution are based on evidence that urban residents typically spend more than 90 percent of their time indoors, concentrations of some contaminants are higher indoors than outdoors, and for some pollutants personal exposures are not characterized adequately by outdoor measurements. Among the more important indoor contaminants associated with health or irritation effects are passive tobacco smoke, radon decay products, carbon monoxide, nitrogen dioxide, formaldehyde, asbestos fibers, microorganisms, and aeroallergens. Efforts to assess health risks associated with indoor air pollution are limited by insufficient information about the number of people exposed, the pattern and severity of exposures, and the health consequences of exposures. An overall strategy should be developed to investigate indoor exposures, health effects, control options, and public policy alternatives.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spengler, J D -- Sexton, K -- ES-01108/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 1;221(4605):9-17.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857273" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Adult ; Air Microbiology ; Air Pollution/*adverse effects/prevention & control ; Air Pollution, Radioactive/adverse effects ; Asbestos/adverse effects ; Carbon Monoxide/adverse effects ; Child ; Construction Materials/adverse effects ; Formaldehyde/adverse effects ; Fuel Oils/adverse effects ; Household Articles ; Humans ; Public Policy ; Radon/adverse effects ; Smoke/adverse effects ; Smoking ; Tobacco Smoke Pollution/adverse effects ; Ventilation
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 94
    Publikationsdatum: 1983-03-18
    Beschreibung: Flow cytometry revealed that, in the presence of tritiated thymidine, a greater percentage of phytohemagglutinin-stimulated lymphocytes from old human donors were arrested in the G2 or M phase than were cells from young donors. Furthermore, lymphocytes from old donors showed significantly more chromosomal damage than did lymphocytes from young donors. Lymphocyte cultures from old or young donors not exposed to tritiated thymidine had the same percentage of cycling lymphocytes in G2 or M, although the number of lymphocytes stimulated by phytohemagglutinin to enter the cell cycle was significantly lower in cultures from old donors. Thus, the impaired incorporation of tritiated thymidine by phytohemagglutinin-exposed lymphocytes from old humans reflects both an impaired proliferative response to phytohemagglutinin and an increased sensitivity to the radiobiological effects of tritiated thymidine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Staiano-Coico, L -- Darzynkiewicz, Z -- Hefton, J M -- Dutkowski, R -- Darlington, G J -- Weksler, M E -- New York, N.Y. -- Science. 1983 Mar 18;219(4590):1335-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828861" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Aged ; *Aging ; Cell Cycle/*radiation effects ; Chromosomes/*radiation effects/ultrastructure ; DNA Repair/radiation effects ; Humans ; Middle Aged ; Thymidine/adverse effects ; Tritium
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 95
    facet.materialart.
    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1984-08-03
    Beschreibung: The nucleotide sequence of a human Blym-1 transforming gene activated in a Burkitt's lymphoma cell line was determined. This sequence predicts a small protein of 58 amino acids that is 33 percent identical to the predicted product of chicken Blym-1, the activated transforming gene of chicken B cell lymphomas. Both the human and chicken Blym-1 genes exhibit significant identity to an amino-terminal region of transferrins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diamond, A -- Devine, J M -- Cooper, G M -- CA 07250/CA/NCI NIH HHS/ -- CA 28946/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 3;225(4661):516-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6330897" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Base Sequence ; Burkitt Lymphoma/*genetics ; Cell Line ; *Cell Transformation, Neoplastic ; DNA Restriction Enzymes ; Humans ; *Oncogenes ; Structure-Activity Relationship ; Transcription, Genetic ; Transferrin/genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 96
    facet.materialart.
    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1984-12-21
    Beschreibung: Smell identification ability was measured in 1955 persons ranging in age from 5 to 99 years. On the average, women outperformed men at all ages, and nonsmokers outperformed smokers. Peak performance occurred in the third through fifth decades and declined markedly after the seventh. More than half of those 65 to 80 years old evidenced major olfactory impairment. After 80 years, more than three-quarters evidenced major impairment. Given these findings, it is not surprising that many elderly persons complain that food lacks flavor and that the elderly account for a disproportionate number of accidental gas poisoning cases each year.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Doty, R L -- Shaman, P -- Applebaum, S L -- Giberson, R -- Siksorski, L -- Rosenberg, L -- NS 16265/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1984 Dec 21;226(4681):1441-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6505700" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Adult ; Aged ; *Aging ; Child ; Child, Preschool ; Female ; Humans ; Male ; Middle Aged ; Sensory Thresholds ; Sex Factors ; Smell/*physiology ; Smoking
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 97
    facet.materialart.
    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1984-01-06
    Beschreibung: Gilvocarcins that are antitumor agents are activated by low doses of visible light to induce bacteriophage lambda in Escherichia coli. This result is dependent on interaction with DNA. Gilvocarcin M, an analog without antitumor activity, failed to induce the prophage after light exposure, thus demonstrating a correlation between photosensitizing and antitumor activities. These results raise several possibilities regarding the mode of action of gilvocarcins as antitumor agents in vivo, involving light or enzymatic activating systems, which could be exploited in human cancer therapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Elespuru, R K -- Gonda, S K -- New York, N.Y. -- Science. 1984 Jan 6;223(4631):69-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6229029" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Aminoglycosides ; *Anti-Bacterial Agents ; Antibiotics, Antineoplastic/*pharmacology/radiation effects ; Bacteriophage lambda/growth & development ; Benzopyrans ; Coumarins ; Glycosides/pharmacology/radiation effects ; *Light ; Methoxsalen/pharmacology ; Structure-Activity Relationship ; Trioxsalen/pharmacology ; Ultraviolet Rays ; Virus Activation/*drug effects
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 98
    facet.materialart.
    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1984-01-20
    Beschreibung: Peptide synthesis can be used for elucidating the roles of secondary structures in the specificity of hormones, antigens, and toxins. Intermediate sized peptides with these activities assume amphiphilic secondary structures in the presence of membranes. When models are designed to optimize the amphiphilicity of the secondary structure, stronger interactions can be observed with the synthetic peptides than with the naturally occurring analogs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, E T -- Kezdy, F J -- HL-18577/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 20;223(4633):249-55.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322295" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Apolipoprotein A-I ; Apolipoproteins ; Binding Sites ; Calcitonin ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone ; Endorphins ; Glucagon ; Growth Hormone-Releasing Hormone ; *Hormones/pharmacology ; Lipoproteins, HDL ; Melitten ; Models, Structural ; *Peptides/chemical synthesis/metabolism/pharmacology ; Protein Conformation ; Structure-Activity Relationship ; beta-Endorphin
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 99
    facet.materialart.
    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1984-03-30
    Beschreibung: Coronary arteries from hearts of cardiac patients contain significantly higher concentrations of histamine than do those from noncardiac patients. The coronary vessels of cardiac patients are also hyperresponsive to histamine and serotonin. These differences between groups of patients suggest an explanation for coronary artery spasm in heart disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kalsner, S -- Richards, R -- New York, N.Y. -- Science. 1984 Mar 30;223(4643):1435-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6701530" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Aged ; Animals ; Arteriosclerosis/physiopathology ; Catecholamines/analysis ; Cattle ; Coronary Vasospasm/*physiopathology ; Coronary Vessels/analysis/drug effects/*physiopathology ; Female ; Histamine/*analysis/pharmacology ; Humans ; Male ; Middle Aged ; Norepinephrine/pharmacology ; Serotonin/analysis/pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 100
    Publikationsdatum: 1984-05-04
    Beschreibung: Peripheral blood lymphocytes from patients with the acquired immunodeficiency syndrome (AIDS) or with signs or symptoms that frequently precede AIDS (pre-AIDS) were grown in vitro with added T-cell growth factor and assayed for the expression and release of human T-lymphotropic retroviruses (HTLV). Retroviruses belonging to the HTLV family and collectively designated HTLV-III were isolated from a total of 48 subjects including 18 of 21 patients wih pre-AIDS, three of four clinically normal mothers of juveniles with AIDS, 26 of 72 adult and juvenile patients with AIDS, and from one of 22 normal male homosexual subjects. No HTLV-III was detected in or isolated from 115 normal heterosexual subjects. The number of HTLV-III isolates reported here underestimates the true prevalence of the virus since many specimens were received in unsatisfactory condition. Other data show that serum samples from a high proportion of AIDS patients contain antibodies to HTLV-III. That these new isolates are members of the HTLV family but differ from the previous isolates known as HTLV-I and HTLV-II is indicated by their morphological, biological, and immunological characteristics. These results and those reported elsewhere in this issue suggest that HTLV-III may be the primary cause of AIDS.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallo, R C -- Salahuddin, S Z -- Popovic, M -- Shearer, G M -- Kaplan, M -- Haynes, B F -- Palker, T J -- Redfield, R -- Oleske, J -- Safai, B -- New York, N.Y. -- Science. 1984 May 4;224(4648):500-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6200936" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/blood/*microbiology ; Adult ; Antigens, Viral/analysis ; Cells, Cultured ; Cytopathogenic Effect, Viral ; Deltaretrovirus/*isolation & purification/physiology/ultrastructure ; Female ; Homosexuality ; Humans ; Immune Sera/pharmacology ; Interferon Type I/immunology ; Male ; RNA-Directed DNA Polymerase/metabolism ; Risk ; T-Lymphocytes/microbiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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