Abstract
A high incidence of tumor regression was observed in guinea pigs bearing transplantable, line-10 hepatocellular carcinomas when synthetic muramyl dipeptides combined with trehalose dimycolate in oil-in-water emulsions were injected directly into the tumors. These compounds are promising candidates to replace viable bacillus Calmette-Guérin in cancer immunotherapy in humans and animals.
MeSH terms
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Acetylmuramyl-Alanyl-Isoglutamine / administration & dosage
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Acetylmuramyl-Alanyl-Isoglutamine / therapeutic use*
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Animals
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Cord Factors / administration & dosage
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Cord Factors / therapeutic use*
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Drug Combinations
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Emulsions
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Glycolipids / therapeutic use*
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Glycopeptides / therapeutic use*
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Immunotherapy
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Liver Neoplasms, Experimental / therapy*
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Lymphatic Metastasis
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Structure-Activity Relationship
Substances
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Cord Factors
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Drug Combinations
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Emulsions
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Glycolipids
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Glycopeptides
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Acetylmuramyl-Alanyl-Isoglutamine