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  • Articles  (320)
  • United States  (180)
  • Male  (145)
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  • American Association for the Advancement of Science (AAAS)  (320)
  • American Chemical Society
  • Periodicals Archive Online (PAO)
  • 1995-1999  (320)
  • 1985-1989
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  • 1965-1969
  • 1995  (320)
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  • Articles  (320)
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  • American Association for the Advancement of Science (AAAS)  (320)
  • American Chemical Society
  • Periodicals Archive Online (PAO)
  • Springer  (2)
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  • 1995-1999  (320)
  • 1985-1989
  • 1980-1984
  • 1965-1969
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  • 1
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    The Devi case and more (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-08-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stewart, W W -- Feder, N -- New York, N.Y. -- Science. 1995 Aug 25;269(5227):1030-1; author reply 1034.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7652538" target="_blank"〉PubMed〈/a〉
    Keywords: *Authorship ; Cryptococcus neoformans/*immunology ; *Fungal Vaccines ; Humans ; National Institutes of Health (U.S.) ; Plagiarism ; *Publishing ; United States ; United States Office of Research Integrity ; Vaccines, Conjugate
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Clinton holds the line on R&D (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-02-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, J -- New York, N.Y. -- Science. 1995 Feb 10;267(5199):780-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7846519" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; Financing, Government ; Government Agencies/*economics ; National Institutes of Health (U.S.)/*economics ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    NSF moves into FastLane to manage flow of grants (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-01-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, J -- New York, N.Y. -- Science. 1995 Jan 13;267(5195):166-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7809618" target="_blank"〉PubMed〈/a〉
    Keywords: *Computer Communication Networks ; Financing, Government ; *Government Agencies ; National Institutes of Health (U.S.) ; *Research Support as Topic ; Software ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Increased cortical representation of the fingers of the left hand in string players (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-10-13
    Description: Magnetic source imaging revealed that the cortical representation of the digits of the left hand of string players was larger than that in controls. The effect was smallest for the left thumb, and no such differences were observed for the representations of the right hand digits. The amount of cortical reorganization in the representation of the fingering digits was correlated with the age at which the person had begun to play. These results suggest that the representation of different parts of the body in the primary somatosensory cortex of humans depends on use and changes to conform to the current needs and experiences of the individual.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Elbert, T -- Pantev, C -- Wienbruch, C -- Rockstroh, B -- Taub, E -- New York, N.Y. -- Science. 1995 Oct 13;270(5234):305-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, University of Konstanz, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7569982" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Afferent Pathways ; Aging ; Brain Mapping ; Fingers/*innervation ; Humans ; Magnetoencephalography ; *Music ; *Neuronal Plasticity ; Neurons, Afferent/*physiology ; Physical Stimulation ; Somatosensory Cortex/anatomy & histology/*physiology ; Thumb/*innervation ; Touch
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Article copying (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-01-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Higgins, T V -- New York, N.Y. -- Science. 1995 Jan 6;267(5194):13.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7809598" target="_blank"〉PubMed〈/a〉
    Keywords: Copyright/*legislation & jurisprudence ; Periodicals as Topic ; Societies, Scientific ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Breast cancer activists seek voice in research decisions (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-09-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Erikson, J -- New York, N.Y. -- Science. 1995 Sep 15;269(5230):1508-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7667631" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; *Biomedical Research ; *Breast Neoplasms ; *Consumer Advocacy ; Consumer Organizations ; Ethical Review ; Federal Government ; Female ; Humans ; National Institutes of Health (U.S.) ; Peer Review, Research ; *Research ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    FFA-1, a protein that promotes the formation of replication centers within nuclei (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-09-29
    Description: In the nuclei of eukaryotic cells, initiation of DNA replication occurs at a discrete number of foci. One component of these foci is the DNA replication factor RP-A. Here, the process leading to the association of RP-A with foci was reconstituted with cytosolic fractions derived from Xenopus eggs. With the use of this fractionated system, a 170-kilodalton protein required for the assembly of RP-A into foci was identified and purified. The protein appears to be an integral component of the foci at which replication of DNA is initiated in eukaryotic nuclei.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yan, H -- Newport, J -- GM33523/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1995 Sep 29;269(5232):1883-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of California, San Diego, Department of Biology, La Jolla, CA 92093, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7569932" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Nucleus/*metabolism ; Cell-Free System ; Cytosol/chemistry ; *DNA Replication ; DNA, Single-Stranded/metabolism ; DNA-Binding Proteins/*metabolism ; Female ; Male ; Molecular Weight ; Oocytes ; Orientation ; Proteins/chemistry/*metabolism ; Replication Protein A ; Xenopus
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Fisher given new role in cancer project (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-03-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Erikson, J -- New York, N.Y. -- Science. 1995 Mar 24;267(5205):1762.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7892594" target="_blank"〉PubMed〈/a〉
    Keywords: Administrative Personnel ; Breast Neoplasms/surgery ; *Clinical Trials as Topic ; History, 20th Century ; Humans ; Intestinal Neoplasms/surgery ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Vietnam. Joint dioxin research imperiled (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-07-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, R -- New York, N.Y. -- Science. 1995 Jul 21;269(5222):298.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7618097" target="_blank"〉PubMed〈/a〉
    Keywords: 2,4,5-Trichlorophenoxyacetic Acid/*adverse effects/analysis ; 2,4-Dichlorophenoxyacetic Acid/*adverse effects/analysis ; Defoliants, Chemical/*adverse effects ; Dioxins/*adverse effects/analysis ; Humans ; *International Cooperation ; National Institutes of Health (U.S.) ; *Research ; Tetrachlorodibenzodioxin/*adverse effects/analysis ; United States ; Vietnam ; World Health Organization
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Copying articles (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-02-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hill, R -- New York, N.Y. -- Science. 1995 Feb 10;267(5199):773.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7846514" target="_blank"〉PubMed〈/a〉
    Keywords: Copyright/*legislation & jurisprudence ; Periodicals as Topic ; *Societies, Scientific ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 11
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    Yellowstone managers stake a claim on hot-springs microbes (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-10-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Milstein, M -- New York, N.Y. -- Science. 1995 Oct 13;270(5234):226.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7569966" target="_blank"〉PubMed〈/a〉
    Keywords: Archaea/classification/isolation & purification ; Biological Evolution ; Biotechnology/*economics ; Conservation of Natural Resources/*economics ; Hot Temperature ; United States ; *Water Microbiology ; Wyoming
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 12
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    Animal testing and EPA (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-12-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Farland, W H -- Vaughn-Dellarco, V -- New York, N.Y. -- Science. 1995 Dec 22;270(5244):1907, 1909.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8533076" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Carcinogenicity Tests ; Diet ; Humans ; Risk Assessment ; *Toxicity Tests ; United States ; *United States Environmental Protection Agency
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 13
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    Key NASA lab under fire for animal care practices (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-06-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, A -- New York, N.Y. -- Science. 1995 Jun 23;268(5218):1692.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7792586" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Welfare/*standards ; Animals ; Rats ; Research/*standards ; United States ; *United States National Aeronautics and Space Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    Dissociation of synchronization and excitability in furosemide blockade of epileptiform activity (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-10-06
    Description: Furosemide, a chloride cotransport inhibitor, reversibly blocked synchronized burst discharges in hippocampal slices without reducing the pyramidal cell response to single electrical stimuli. Images of the intrinsic optical signal acquired during these slice experiments indicated that furosemide coincidentally blocked changes in extracellular space. In urethane-anesthetized rats, systemically injected furosemide blocked kainic acid-induced electrical discharges recorded from cortex. These results suggest that (i) neuronal synchronization involved in epileptiform activity can be dissociated from synaptic excitability; (ii) nonsynaptic mechanisms, possibly associated with furosemide-sensitive cell volume regulation, may be critical for synchronization of neuronal activity; and (iii) agents that affect extracellular volume may have clinical utility as antiepileptic drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hochman, D W -- Baraban, S C -- Owens, J W -- Schwartzkroin, P A -- NS07144/NS/NINDS NIH HHS/ -- NS15317/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1995 Oct 6;270(5233):99-102.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurological Surgery, University of Washington, Seattle 98195, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7569957" target="_blank"〉PubMed〈/a〉
    Keywords: 4-Aminopyridine/pharmacology ; Animals ; Anticonvulsants/*pharmacology ; Bicuculline/pharmacology ; Electric Stimulation ; Entorhinal Cortex/physiology ; Extracellular Space/drug effects/physiology ; Female ; Furosemide/*pharmacology ; Hippocampus/drug effects/*physiology ; In Vitro Techniques ; Kainic Acid/pharmacology ; Magnesium/pharmacology ; Male ; Membrane Potentials/drug effects ; Potassium/pharmacology ; Pyramidal Cells/drug effects/*physiology ; Rats ; Rats, Sprague-Dawley ; Status Epilepticus/chemically induced/*physiopathology ; Synaptic Transmission/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 15
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    The Devi case and more (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-08-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Young-Horvath, V -- New York, N.Y. -- Science. 1995 Aug 25;269(5227):1033-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7652544" target="_blank"〉PubMed〈/a〉
    Keywords: *Authorship ; Ethics, Professional ; National Institutes of Health (U.S.)/*standards ; Research/*standards ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 16
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    A neuropeptide gene defined by the Drosophila memory mutant amnesiac (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-05-12
    Description: Mutations in genes required for associative learning and memory in Drosophila exist, but isolation of the genes has been difficult because most are defined by a single, chemically induced allele. Here, a simplified genetic screen was used to identify candidate genes involved in learning and memory. Second site suppressors of the dunce (dnc) female sterility phenotype were isolated with the use of transposon mutagenesis. One suppressor mutation that was recovered mapped in the amnesiac (amn) gene. Cloning of the locus revealed that amn encodes a previously uncharacterized neuropeptide gene. Thus, with the cloning of amn, specific neuropeptides are implicated in the memory process.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Feany, M B -- Quinn, W G -- New York, N.Y. -- Science. 1995 May 12;268(5212):869-73.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7754370" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Cloning, Molecular ; Codon ; DNA Transposable Elements ; DNA, Complementary/genetics ; Drosophila/*genetics/physiology ; *Drosophila Proteins ; Female ; *Genes, Insect ; Growth Hormone-Releasing Hormone/chemistry/genetics ; Male ; Memory/*physiology ; Molecular Sequence Data ; Mutagenesis, Insertional ; Mutation ; Neuropeptides/chemistry/*genetics ; Pituitary Adenylate Cyclase-Activating Polypeptide ; Sequence Homology, Amino Acid ; Suppression, Genetic
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 17
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    Rockefeller strikes fat deal with Amgen (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-05-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, R -- New York, N.Y. -- Science. 1995 May 5;268(5211):631.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7732366" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes/economics ; Biotechnology/*economics ; *Genes ; Humans ; Obesity/genetics ; *Patents as Topic ; United States ; Universities/*economics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 18
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    Texaco offers to settle copyright case (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-05-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, A -- New York, N.Y. -- Science. 1995 May 26;268(5214):1127.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7761826" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Industry/economics/*legislation & jurisprudence ; Copying Processes/economics/*legislation & jurisprudence ; Copyright/*legislation & jurisprudence ; Licensure/economics ; Periodicals as Topic/*legislation & jurisprudence ; Petroleum ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 19
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    Requirement of FGF-4 for postimplantation mouse development (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-01-13
    Description: Fibroblast growth factors (FGFs) are thought to influence many processes in vertebrate development because of their diverse sites of expression and wide range of biological activities in in vitro culture systems. As a means of elucidating embryonic functions of FGF-4, gene targeting was used to generate mice harboring a disrupted Fgf4 gene. Embryos homozygous for the null allele underwent uterine implantation and induced uterine decidualization but did not develop substantially thereafter. As was consistent with their behavior in vivo, Fgf4 null embryos cultured in vitro displayed severely impaired proliferation of the inner cell mass, whereas growth and differentiation of the inner cell mass were rescued when null embryos were cultured in the presence of FGF-4 protein.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Feldman, B -- Poueymirou, W -- Papaioannou, V E -- DeChiara, T M -- Goldfarb, M -- HD21988/HD/NICHD NIH HHS/ -- HD27198/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1995 Jan 13;267(5195):246-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Integrated Program in Cellular, Molecular, and Biophysical Studies, Columbia University College of Physicians and Surgeons, New York, NY 10032.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7809630" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Blastocyst/cytology/physiology ; Crosses, Genetic ; Culture Techniques ; Embryonic Development/*physiology ; Embryonic and Fetal Development/*physiology ; Female ; Fibroblast Growth Factor 4 ; Fibroblast Growth Factors/genetics/pharmacology/*physiology ; Gene Targeting ; Heterozygote ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; Morula/drug effects/physiology ; Phenotype ; Pregnancy ; Proto-Oncogene Proteins/genetics/pharmacology/*physiology ; Recombinant Proteins/pharmacology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 20
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    Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-06-02
    Description: Fas (also known as Apo1 and CD95) is a cell surface receptor involved in apoptotic cell death. Fas expression and function were analyzed in three children (including two siblings) with a lymphoproliferative syndrome, two of whom also had autoimmune disorders. A large deletion in the gene encoding Fas and no detectable cell surface expression characterized the most affected patient. Clinical manifestations in the two related patients were less severe: Fas-mediated apoptosis was impaired and a deletion within the intracytoplasmic domain was detected. These findings illustrate the crucial regulatory role of Fas and may provide a molecular basis for some autoimmune diseases in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rieux-Laucat, F -- Le Deist, F -- Hivroz, C -- Roberts, I A -- Debatin, K M -- Fischer, A -- de Villartay, J P -- New York, N.Y. -- Science. 1995 Jun 2;268(5215):1347-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut National de la Sante et de la Recherche Medicale (INSERM) U 429, Hopital Necker-Enfants Malades, Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7539157" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Antigens, CD95 ; Antigens, Surface/chemistry/*genetics/physiology ; Apoptosis ; Autoimmune Diseases/*genetics/immunology/pathology ; Base Sequence ; Child ; Female ; *Frameshift Mutation ; Humans ; Infant ; Lymphoproliferative Disorders/*genetics/immunology/pathology ; Male ; Molecular Sequence Data ; Sequence Deletion ; Syndrome ; Thrombocytopenia/genetics/immunology/pathology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Companies fear FDA rule on antibodies (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-04-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, R -- New York, N.Y. -- Science. 1995 Apr 28;268(5210):494.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7725089" target="_blank"〉PubMed〈/a〉
    Keywords: *Antibodies ; Equipment and Supplies ; Immunohistochemistry/*standards ; *Legislation, Drug ; Sensitivity and Specificity ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 22
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    Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-06-23
    Description: Deficiency in monoamine oxidase A (MAOA), an enzyme that degrades serotonin and norepinephrine, has recently been shown to be associated with aggressive behavior in men of a Dutch family. A line of transgenic mice was isolated in which transgene integration caused a deletion in the gene encoding MAOA, providing an animal model of MAOA deficiency. In pup brains, serotonin concentrations were increased up to ninefold, and serotonin-like immunoreactivity was present in catecholaminergic neurons. In pup and adult brains, norepinephrine concentrations were increased up to twofold, and cytoarchitectural changes were observed in the somatosensory cortex. Pup behavioral alterations, including trembling, difficulty in righting, and fearfulness were reversed by the serotonin synthesis inhibitor parachlorophenylalanine. Adults manifested a distinct behavioral syndrome, including enhanced aggression in males.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844866/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844866/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cases, O -- Seif, I -- Grimsby, J -- Gaspar, P -- Chen, K -- Pournin, S -- Muller, U -- Aguet, M -- Babinet, C -- Shih, J C -- K05 MH 00796/MH/NIMH NIH HHS/ -- R01 MH 37020/MH/NIMH NIH HHS/ -- R37 MH 39085/MH/NIMH NIH HHS/ -- R37 MH039085/MH/NIMH NIH HHS/ -- R37 MH039085-23/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1995 Jun 23;268(5218):1763-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre National de la Recherche Scientifique (CNRS), Unite de Recherche Associee (URA), Institut Curie, Orsay, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7792602" target="_blank"〉PubMed〈/a〉
    Keywords: Aggression/*physiology ; Amino Acid Sequence ; Animals ; Base Sequence ; Blotting, Southern ; Brain/*metabolism ; Disease Models, Animal ; Dopamine/metabolism ; Female ; Interferon-beta/genetics ; Male ; Mice ; Mice, Inbred C3H ; Mice, Transgenic ; Molecular Sequence Data ; Monoamine Oxidase/*deficiency ; Norepinephrine/*metabolism ; Sequence Deletion ; Serotonin/*metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    A molecular approach to cancer risk (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-04-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, R -- New York, N.Y. -- Science. 1995 Apr 21;268(5209):356-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7716533" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Carcinogenicity Tests ; Carcinogens/*toxicity ; Chloroform/toxicity ; Dioxins/toxicity ; Dose-Response Relationship, Drug ; Guidelines as Topic ; Humans ; National Institutes of Health (U.S.) ; Neoplasms/*chemically induced ; Risk Assessment ; Structure-Activity Relationship ; United States ; United States Environmental Protection Agency
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Congressman ties genome bucks to ethics (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-03-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, Richard -- New York, N.Y. -- Science. 1995 Mar 31;267(5206):1895.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11644749" target="_blank"〉PubMed〈/a〉
    Keywords: Federal Government ; *Financing, Government ; Genetic Predisposition to Disease ; Genetic Testing ; Government ; Government Regulation ; *Human Genome Project ; Humans ; National Institutes of Health (U.S.) ; Politics ; Prejudice ; Social Control, Formal ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    The complexities of conception (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-07-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Aitken, R J -- New York, N.Y. -- Science. 1995 Jul 7;269(5220):39-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Reproductive Biology Unit, Medical Research Council, Edinburgh, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7604276" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Egg Proteins/*metabolism ; Female ; Humans ; Lectins/metabolism ; Male ; Membrane Glycoproteins/*metabolism ; Mice ; Phosphorylation ; Proto-Oncogene Proteins ; Receptor Protein-Tyrosine Kinases/*metabolism ; Receptors, Cell Surface/*metabolism ; Sperm-Ovum Interactions/*physiology ; Spermatozoa/metabolism ; Zona Pellucida/*metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Radiation studies (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-02-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Akiyama, M -- Kodama, K -- Mabuchi, K -- Ohara, J L -- Preston, D L -- Satoh, C -- Akahoshi, M -- Honda, T -- Soda, M -- New York, N.Y. -- Science. 1995 Feb 24;267(5201):1077.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7855582" target="_blank"〉PubMed〈/a〉
    Keywords: Government Agencies ; Humans ; International Cooperation ; Japan ; *Nuclear Warfare ; *Radiation Injuries ; Survivors ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    The Devi case and more (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-08-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robbins, J B -- Schneerson, R -- Bennett, J E -- New York, N.Y. -- Science. 1995 Aug 25;269(5227):1031; author reply 1034.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7652539" target="_blank"〉PubMed〈/a〉
    Keywords: *Authorship ; National Institutes of Health (U.S.) ; Plagiarism ; *Publishing ; United States ; United States Office of Research Integrity
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Translational suppression by trinucleotide repeat expansion at FMR1 (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-05-05
    Description: Fragile X syndrome is the result of the unstable expansion of a trinucleotide repeat in the 5'-untranslated region of the FMR1 gene. Fibroblast subclones from a mildly affected patient, each containing stable FMR1 alleles with 57 to 285 CGG repeats, were shown to exhibit normal steady-state levels of FMR1 messenger RNA. However, FMR protein was markedly diminished from transcript with more than 200 repeats. Such transcripts were associated with stalled 40S ribosomal subunits. These results suggest that a structural RNA transition beyond 200 repeats impedes the linear 40S migration along the 5'-untranslated region. This results in translational inhibition by trinucleotide repeat expansion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Feng, Y -- Zhang, F -- Lokey, L K -- Chastain, J L -- Lakkis, L -- Eberhart, D -- Warren, S T -- HD20521/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1995 May 5;268(5211):731-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Emory University School of Medicine, Atlanta, GA 30322.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7732383" target="_blank"〉PubMed〈/a〉
    Keywords: Centrifugation, Density Gradient ; Clone Cells ; Down-Regulation/genetics ; Female ; Fibroblasts/chemistry ; Fragile X Mental Retardation Protein ; Fragile X Syndrome/*genetics ; Humans ; Infant ; Male ; Nerve Tissue Proteins/*genetics ; Polymerase Chain Reaction ; Protein Biosynthesis/*genetics ; RNA, Messenger/analysis ; *RNA-Binding Proteins ; Repetitive Sequences, Nucleic Acid/*genetics
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 29
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    RERF scientific agenda and DOE (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-05-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Akiyama, M -- Kodama, K -- Mabuchi, K -- Ohara, J L -- Preston, D L -- Satoh, C -- Akahoshi, M -- Shibata, Y -- Soda, M -- New York, N.Y. -- Science. 1995 May 19;268(5213):958-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7619153" target="_blank"〉PubMed〈/a〉
    Keywords: Foundations/*organization & administration ; *Government Agencies ; Japan ; *Radiation Injuries ; United States
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    Genetic discrimination (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-11-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holtzman, S -- Hillback, E D Jr -- New York, N.Y. -- Science. 1995 Nov 24;270(5240):1283.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7481810" target="_blank"〉PubMed〈/a〉
    Keywords: Biotechnology ; *Genetics, Medical ; Health Care Reform ; Humans ; *Insurance Selection Bias ; Insurance, Health/*legislation & jurisprudence ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Panel clears NIH in patient deaths (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-03-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, R -- New York, N.Y. -- Science. 1995 Mar 24;267(5205):1759.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7892593" target="_blank"〉PubMed〈/a〉
    Keywords: Antiviral Agents/*adverse effects ; Arabinofuranosyluracil/adverse effects/*analogs & derivatives ; Clinical Trials as Topic/*standards ; Drug-Induced Liver Injury ; Humans ; Institute of Medicine (U.S.) ; *National Institutes of Health (U.S.) ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Risk assessment. Agencies decry fuzzy science in bill (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-02-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, R -- New York, N.Y. -- Science. 1995 Feb 24;267(5201):1089-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7855587" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; Cost-Benefit Analysis ; Environmental Exposure/*legislation & jurisprudence ; Government Agencies/legislation & jurisprudence ; Humans ; Lead/*blood ; Risk Assessment ; United States ; United States Environmental Protection Agency/*legislation & jurisprudence
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 33
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    Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-05-05
    Description: The aryl hydrocarbon (Ah) receptor (AHR) mediates many carcinogenic and teratogenic effects of environmentally toxic chemicals such as dioxin. An AHR-deficient (Ahr-/-) mouse line was constructed by homologous recombination in embryonic stem cells. Almost half of the mice died shortly after birth, whereas survivors reached maturity and were fertile. The Ahr-/- mice showed decreased accumulation of lymphocytes in the spleen and lymph nodes, but not in the thymus. The livers of Ahr-/- mice were reduced in size by 50 percent and showed bile duct fibrosis Ahr-/- mice were also nonresponsive with regard to dioxin-mediated induction of genes encoding enzymes that catalyze the metabolism of foreign compounds. Thus, the AHR plays an important role in the development of the liver and the immune system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fernandez-Salguero, P -- Pineau, T -- Hilbert, D M -- McPhail, T -- Lee, S S -- Kimura, S -- Nebert, D W -- Rudikoff, S -- Ward, J M -- Gonzalez, F J -- P30 ES06096/ES/NIEHS NIH HHS/ -- R01 ES06811/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 1995 May 5;268(5211):722-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7732381" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Gene Expression Regulation/physiology ; Immunity/*physiology ; Liver/*physiology ; Liver Cirrhosis, Experimental/genetics/pathology ; Lymphoid Tissue/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Aryl Hydrocarbon/genetics/*physiology
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    Global approaches to the promotion of women's health (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-08-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mongella, G -- New York, N.Y. -- Science. 1995 Aug 11;269(5225):789-90.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Fourth World Conference on Women, United Nations, New York, NY 10017, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7638591" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/epidemiology/transmission ; Aging ; Biomedical Research ; Female ; *Global Health ; Health Promotion ; Humans ; *Internationality ; Life Expectancy ; Male ; Neoplasms/epidemiology ; Poverty ; Research ; Research Support as Topic ; Resource Allocation ; Sex Characteristics ; Violence ; *Women's Health ; Women's Health Services ; World Health Organization
    Print ISSN: 0036-8075
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    Scientific misconduct. Federal panel recommends universities play bigger role (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-01-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, R -- New York, N.Y. -- Science. 1995 Jan 27;267(5197):449.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7824941" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Biomedical Research ; Federal Government ; Government Regulation ; *Scientific Misconduct ; United States ; Universities/*standards
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 36
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    Genetic feminization of brain structures and changed sexual orientation in male Drosophila (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-02-10
    Description: The neural basis of sexual orientation in Drosophila was studied by the production of males with regionally feminized brains. Such flies express the female form of the sex determination gene transformer in a limited number of neurons under the control of GAL4 enhancer trap inserts. This method facilitated the creation of lines with a stable pattern of feminization. In tests of sexual preferences, flies that were feminized in a portion of the antennal lobes or in a subset of the corpora pedunculata (mushroom bodies) courted both males and females. These two brain structures, both of which are involved in olfactory processing, may function in the recognition of sex-specific pheromones, in the control of sex-specific behaviors, or both.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ferveur, J F -- Stortkuhl, K F -- Stocker, R F -- Greenspan, R J -- New York, N.Y. -- Science. 1995 Feb 10;267(5199):902-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, New York University, NY 10003.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7846534" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bisexuality ; Brain/physiology ; Drosophila melanogaster/genetics/*physiology ; Female ; *Genes, Insect ; Male ; Sex Attractants/physiology ; Sexual Behavior, Animal ; Smell
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    Rules would drop need for clinical data (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-01-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, R -- New York, N.Y. -- Science. 1995 Jan 6;267(5194):23-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7809603" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biotechnology/*legislation & jurisprudence ; Humans ; *Patents as Topic ; United States ; United States Food and Drug Administration
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 38
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    Regulation of human gene therapy (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-07-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chase, G A -- DeLeon, P A -- Dronamraju, K R -- Erickson, R P -- Glorioso, J C 3rd -- Hirschhorn, R -- Lysaught, M T -- McGraw, K M -- Meyers, A S -- Miller, A D -- New York, N.Y. -- Science. 1995 Jul 7;269(5220):14-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7604272" target="_blank"〉PubMed〈/a〉
    Keywords: *Advisory Committees ; Clinical Protocols ; Clinical Trials, Phase I as Topic/legislation & jurisprudence ; Clinical Trials, Phase II as Topic/legislation & jurisprudence ; DNA, Recombinant ; Ethical Review ; Federal Government ; Genetic Therapy/*legislation & jurisprudence ; *Government Regulation ; Humans ; *National Institutes of Health (U.S.) ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Attacking the causes of "silent" infertility (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-08-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morell, V -- New York, N.Y. -- Science. 1995 Aug 11;269(5225):775-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7638588" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Chlamydia Infections/complications/immunology ; Endometriosis/*complications/genetics ; Female ; Genetic Predisposition to Disease ; Humans ; Infertility, Female/*etiology/genetics ; Infertility, Male/etiology ; Leiomyoma/*complications/genetics ; Male ; Sexually Transmitted Diseases/*complications/epidemiology/immunology ; Uterine Neoplasms/*complications/genetics
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 40
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    Mutations of keratinocyte transglutaminase in lamellar ichthyosis (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-01-27
    Description: Lamellar ichthyosis is a severe congenital skin disorder characterized by generalized large scales and variable redness. Affected individuals in three families exhibited drastically reduced keratinocyte transglutaminase (TGK) activity. In two of these families, expression of TGK transcripts was diminished or abnormal and no TGK protein was detected. Homozygous or compound heterozygous mutations of the TGK gene were identified in all families. These data suggest that defects in TGK cause lamellar ichthyosis and that intact cross-linkage of cornified cell envelopes is required for epidermal tissue homeostasis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huber, M -- Rettler, I -- Bernasconi, K -- Frenk, E -- Lavrijsen, S P -- Ponec, M -- Bon, A -- Lautenschlager, S -- Schorderet, D F -- Hohl, D -- New York, N.Y. -- Science. 1995 Jan 27;267(5197):525-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Dermatology, Centre Hospitalier Universitaire Vandois (CHUV), Hopital de Beaumont, Lausanne, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7824952" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Cell Membrane/metabolism ; Cells, Cultured ; Codon ; Female ; Gene Deletion ; Genetic Linkage ; Heterozygote ; Homozygote ; Humans ; Ichthyosis, Lamellar/enzymology/*genetics ; Introns ; Keratinocytes/*enzymology/ultrastructure ; Male ; Membrane Proteins/metabolism ; Molecular Sequence Data ; Mutation ; Pedigree ; Point Mutation ; Protein Precursors/metabolism ; Transglutaminases/*genetics/metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Zeroing in on how hormones affect the immune system (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-08-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morell, V -- New York, N.Y. -- Science. 1995 Aug 11;269(5225):773-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7638587" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoimmune Diseases/etiology ; Clinical Trials as Topic ; Estrogens/*physiology ; Female ; Genetic Predisposition to Disease ; Genitalia, Female/physiology ; Gonadal Steroid Hormones/*physiology ; Humans ; Immune System/*physiology ; Infection/immunology ; Male ; Menopause ; *Menstrual Cycle
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 42
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    Who owns the past? (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-06-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morell, V -- New York, N.Y. -- Science. 1995 Jun 9;268(5216):1424-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7770766" target="_blank"〉PubMed〈/a〉
    Keywords: Anthropology, Physical/*legislation & jurisprudence ; Archaeology/*legislation & jurisprudence ; *Culture ; Humans ; Indians, North American ; Israel ; Oceanic Ancestry Group ; Tasmania ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 43
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    Unraveling immune privilege (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-11-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Streilein, J W -- New York, N.Y. -- Science. 1995 Nov 17;270(5239):1158-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7502038" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anterior Chamber/immunology ; Fas Ligand Protein ; Graft Rejection ; Graft Survival ; *Immune Tolerance ; Male ; Membrane Glycoproteins/*physiology ; Mice ; Mice, Inbred Strains ; Sertoli Cells/immunology ; T-Lymphocytes/immunology ; *Transplantation Immunology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 44
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    Genetic discrimination and health insurance: an urgent need for reform (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-10-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hudson, K L -- Rothenberg, K H -- Andrews, L B -- Kahn, M J -- Collins, F S -- New York, N.Y. -- Science. 1995 Oct 20;270(5235):391-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7569991" target="_blank"〉PubMed〈/a〉
    Keywords: Federal Government ; Genetic Diseases, Inborn ; *Genetics, Medical ; Government Regulation ; Guidelines as Topic ; *Health Care Reform ; Health Services Accessibility ; Human Genome Project ; Humans ; *Insurance Selection Bias ; *Insurance, Health/legislation & jurisprudence ; *Medically Uninsured ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 45
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    Aggression in mice and men? (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-10-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rose, S P -- New York, N.Y. -- Science. 1995 Oct 20;270(5235):362-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7569986" target="_blank"〉PubMed〈/a〉
    Keywords: *Aggression ; Animals ; *Behavior, Animal ; Humans ; Male ; Mice ; Mice, Transgenic ; Monoamine Oxidase/*deficiency/genetics
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 46
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    The Devi case and more (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-08-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosen, J E -- New York, N.Y. -- Science. 1995 Aug 25;269(5227):1032.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7652541" target="_blank"〉PubMed〈/a〉
    Keywords: *Authorship ; Cryptococcus neoformans/*immunology ; *Fungal Vaccines ; National Institutes of Health (U.S.) ; *Publishing ; United States ; United States Office of Research Integrity ; Vaccines, Conjugate
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  • 47
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    U.S.-Russian space science. Joint mission gets off to slow start (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-01-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, A -- New York, N.Y. -- Science. 1995 Jan 20;267(5196):323.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7824926" target="_blank"〉PubMed〈/a〉
    Keywords: *Astronauts ; Humans ; International Cooperation ; Male ; Russia ; *Space Flight ; *Spacecraft ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 48
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    Scope of the AIDS epidemic in the United States (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-11-24
    Description: Two-dimensional deconvolution techniques are used here to reconstruct age-specific human immunodeficiency virus (HIV) infection rates in the United States from surveillance data on acquired immunodeficiency syndrome (AIDS). This approach suggests that 630,000 to 897,000 adults and adolescents in the United States were living with HIV infection as of January 1993, including 107,000 to 150,000 women. The estimated incidence of HIV infection declined markedly over time among white males, especially those older than 30 years. In contrast, HIV incidence appears to have remained relatively constant among women and minorities. As of January 1993, prevalence was highest among young adults in their late twenties and thirties and among minorities. An estimated 3 percent of black men and 1 percent of black women in their thirties were living with HIV infection as of that date. If infection rates remain at these levels, HIV must be considered as endemic in the United States.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosenberg, P S -- New York, N.Y. -- Science. 1995 Nov 24;270(5240):1372-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Cancer Institute, Rockville, MD 20852-4910, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7481828" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*epidemiology ; Adolescent ; Adult ; African Americans/statistics & numerical data ; Age Distribution ; *Disease Outbreaks ; European Continental Ancestry Group/statistics & numerical data ; Female ; HIV Infections/*epidemiology ; Hispanic Americans/statistics & numerical data ; Humans ; Incidence ; Male ; Middle Aged ; Models, Statistical ; Prevalence ; Sex Distribution ; United States/epidemiology
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  • 49
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    Anthropologists overturn old ideas about new developments (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-04-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fischman, J -- Gibbons, A -- Culotta, E -- New York, N.Y. -- Science. 1995 Apr 21;268(5209):364-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7716536" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Anthropology ; Behavior ; Female ; Fossils ; Genetic Variation ; Haplorhini/physiology ; Hominidae/anatomy & histology ; Humans ; Humerus/anatomy & histology ; Labor, Obstetric ; Male ; Melanesia ; Pregnancy
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 50
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    Primate genetics. Getting the poop on baboon DNA (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-02-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morell, V -- New York, N.Y. -- Science. 1995 Feb 3;267(5198):615-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7839135" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; DNA/analysis/*genetics ; DNA Primers ; DNA, Satellite ; Feces/*chemistry ; Male ; Papio/*genetics ; Polymerase Chain Reaction ; Sequence Analysis, DNA
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 51
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    Herpes-like sequences in HIV-infected and uninfected Kaposi's sarcoma patients (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-04-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ambroziak, J A -- Blackbourn, D J -- Herndier, B G -- Glogau, R G -- Gullett, J H -- McDonald, A R -- Lennette, E T -- Levy, J A -- New York, N.Y. -- Science. 1995 Apr 28;268(5210):582-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7725108" target="_blank"〉PubMed〈/a〉
    Keywords: B-Lymphocyte Subsets/virology ; DNA, Viral/*analysis ; HIV Infections/*complications ; Herpesviridae/*genetics ; Humans ; Leukocytes, Mononuclear/virology ; Male ; Saliva/virology ; Sarcoma, Kaposi/etiology/*virology ; Semen/virology ; Tumor Cells, Cultured
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 52
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    Heso-no-O: a gift (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-12-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moriwaki, K -- Iida, S -- Kinoshita, M -- New York, N.Y. -- Science. 1995 Dec 15;270(5243):1744-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8525358" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Desiccation ; Fetal Blood ; *Genome, Human ; Humans ; Infant ; Infant, Newborn ; Japan ; Preservation, Biological ; *Umbilical Cord
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 53
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    House panel homes in on NIH (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-03-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, A -- Mervis, J -- New York, N.Y. -- Science. 1995 Mar 24;267(5205):1759.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7892592" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets/*legislation & jurisprudence ; Cost Control/legislation & jurisprudence ; National Institutes of Health (U.S.)/*economics ; United States
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  • 54
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    FDA: Congress mixes harsh medicine (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-08-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, A -- Stone, R -- New York, N.Y. -- Science. 1995 Aug 25;269(5227):1038, 1040-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7652549" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biotechnology ; Clinical Trials as Topic ; *Drug Approval/legislation & jurisprudence/organization & administration ; Humans ; Investigational New Drug Application ; United States ; United States Food and Drug Administration/*legislation & ; jurisprudence/organization & administration
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  • 55
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    Aberrant subcellular localization of BRCA1 in breast cancer (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-11-03
    Description: The BRCA1 gene product was identified as a 220-kilodalton nuclear phosphoprotein in normal cells, including breast ductal epithelial cells, and in 18 of 20 tumor cell lines derived from tissues other than breast and ovary. In 16 of 17 breast and ovarian cancer lines and 17 of 17 samples of cells obtained from malignant effusions, however, BRCA1 localized mainly in cytoplasm. Absence of BRCA1 or aberrant subcellular location was also observed to a variable extent in histological sections of many breast cancer biopsies. These findings suggest that BRCA1 abnormalities may be involved in the pathogenesis of many breast cancers, sporadic as well as familial.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, Y -- Chen, C F -- Riley, D J -- Allred, D C -- Chen, P L -- Von Hoff, D -- Osborne, C K -- Lee, W H -- CA58318/CA/NCI NIH HHS/ -- EY05758/EY/NEI NIH HHS/ -- P50CA58183/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1995 Nov 3;270(5237):789-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Molecular Medicine/Institute of Biotechnology, University of Texas Health Science Center at San Antonio 78245, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7481765" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; BRCA1 Protein ; Base Sequence ; Breast/*chemistry ; Breast Neoplasms/*chemistry/ultrastructure ; Cell Fractionation ; Cell Line ; Cell Nucleus/chemistry ; Cytoplasm/*chemistry ; Female ; Humans ; Male ; Molecular Sequence Data ; Mutation ; Neoplasm Proteins/*analysis/genetics/metabolism ; Neoplasms/chemistry/ultrastructure ; Ovarian Neoplasms/chemistry/ultrastructure ; Pleural Effusion, Malignant/chemistry/pathology ; Transcription Factors/*analysis/genetics/metabolism ; Tumor Cells, Cultured
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    Nobel prizes: fly development work bears prize-winning fruit (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-10-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roush, W -- New York, N.Y. -- Science. 1995 Oct 20;270(5235):380-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7569990" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Drosophila melanogaster/*genetics ; Genes, Homeobox ; *Genes, Insect ; Germany ; History, 20th Century ; *Nobel Prize ; United States
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  • 57
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    A simple genetic basis for a complex psychological trait in laboratory mice (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-09-08
    Description: Psychological traits are commonly inferred from covariation in sets of behavioral measures that otherwise appear to have little in common. Emotionality in mice is such a trait, defined here by covariation in activity and defecation in a novel environment and emergence into the open arms of an elevated plus maze. Behavioral and quantitative trait analyses were conducted on four measures obtained from 879 mice from an F2 intercross. Three loci, on murine chromosomes 1, 12, and 15, were mapped that influence emotionality. This trait, inferred from studies of strain, sex, and individual differences in rodents, may be related to human susceptibility to anxiety or neuroticism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flint, J -- Corley, R -- DeFries, J C -- Fulker, D W -- Gray, J A -- Miller, S -- Collins, A C -- DA-00197/DA/NIDA NIH HHS/ -- DA-05131/DA/NIDA NIH HHS/ -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 1995 Sep 8;269(5229):1432-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7660127" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Behavior, Animal ; *Chromosome Mapping ; Defecation ; *Emotions ; Female ; Genes ; *Genetic Linkage ; Genetic Variation ; Lod Score ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Phenotype ; Regression Analysis
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Grad school rankings rankle (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-09-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roush, W -- New York, N.Y. -- Science. 1995 Sep 22;269(5231):1660-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7569885" target="_blank"〉PubMed〈/a〉
    Keywords: Biochemistry/education ; Developmental Biology/education ; Education, Graduate/*standards ; Geology/education ; Molecular Biology/education ; *National Academy of Sciences (U.S.) ; Neurosciences/education ; Physics/education ; United States ; Universities/*standards
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    Arguing over why Johnny can't read (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-03-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roush, W -- New York, N.Y. -- Science. 1995 Mar 31;267(5206):1896-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7701312" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Child ; Chromosomes, Human, Pair 6 ; Dyslexia/diagnosis/epidemiology/*etiology ; Female ; Humans ; Learning Disorders/diagnosis/epidemiology/*etiology ; Magnetic Resonance Imaging ; Male ; National Institutes of Health (U.S.) ; Thalamus/*pathology/physiopathology/*radionuclide imaging ; Tomography, Emission-Computed ; United States/epidemiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    A role for CD5 in TCR-mediated signal transduction and thymocyte selection (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-07-28
    Description: CD5 is a transmembrane protein that is expressed on the surface of T cells and a subset of B cells. The absence of CD5 rendered thymocytes hyperresponsive to stimulation through the T cell antigen receptor (TCR) in vitro. Selection of T cells expressing three distinct transgenic TCRs was also abnormal in CD5-deficient mice. These observations indicate that CD5 can influence the fate of developing thymocytes by acting as a negative regulator of TCR-mediated signal transduction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tarakhovsky, A -- Kanner, S B -- Hombach, J -- Ledbetter, J A -- Muller, W -- Killeen, N -- Rajewsky, K -- New York, N.Y. -- Science. 1995 Jul 28;269(5223):535-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Genetics, University of Cologne, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7542801" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, CD/*immunology ; Antigens, CD3/metabolism ; Antigens, CD5 ; Female ; *Lymphocyte Activation ; Male ; Mice ; Mice, Transgenic ; Phosphorylation ; Protein-Tyrosine Kinases/metabolism ; Receptors, Antigen, T-Cell/*immunology ; *Signal Transduction ; T-Lymphocyte Subsets/immunology ; T-Lymphocytes/*immunology ; Thymus Gland/immunology ; ZAP-70 Protein-Tyrosine Kinase
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    "The Duesberg phenomenon": Duesberg and other voices (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-01-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cline, F A Jr -- New York, N.Y. -- Science. 1995 Jan 20;267(5196):314-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7824921" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/drug therapy/*virology ; HIV/pathogenicity ; Homosexuality, Male ; Humans ; Male ; Research ; Zidovudine/*therapeutic use
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    AIDS-associated Kaposi's sarcoma. "Duesberg phenomenon' (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-02-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ascher, M S -- Sheppard, H W -- New York, N.Y. -- Science. 1995 Feb 24;267(5201):1080.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7726989" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/chemically induced/*etiology ; Humans ; Male ; Street Drugs/*adverse effects ; Zidovudine/adverse effects/therapeutic use
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    Scientists attacked for 'patenting' Pacific tribe (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-11-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taubes, G -- New York, N.Y. -- Science. 1995 Nov 17;270(5239):1112.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7502030" target="_blank"〉PubMed〈/a〉
    Keywords: *Cell Line ; *Ethnic Groups/genetics ; Genes ; *Genetic Diseases, Inborn ; *Genetic Research ; *Human T-lymphotropic virus 1 ; Humans ; Information Dissemination ; Internationality ; Papua New Guinea ; *Patents as Topic ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Selective opioid inhibition of small nociceptive neurons (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-11-24
    Description: Opioid analgesia, the selective suppression of pain without effects on other sensations, also distinguishes between different types of pain: severe, persistent pain is potently inhibited by opioids, but they fail to cohceal the sensation of a pinprick. The cellular basis for this specificity was analyzed by means of patch-clamp experiments performed on fluorescently labeled nociceptive neurons (nociceptors) that innervate rat tooth pulp. Activation of the mu opioid receptor inhibited calcium channels on almost all small nociceptors but had minimal effect on large nociceptors. Somatostatin had the opposite specificity, preferentially inhibiting calcium channels on the large cells. Because persistent pain is mediated by slow-conducting, small nociceptors, opioids are thus likely to inhibit neurotransmitter release only at those primary synapses specialized for persistent pain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taddese, A -- Nah, S Y -- McCleskey, E W -- New York, N.Y. -- Science. 1995 Nov 24;270(5240):1366-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Vollum Institute, Oregon Health Sciences University, Portland 97201, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7481826" target="_blank"〉PubMed〈/a〉
    Keywords: Analgesics/*pharmacology ; Animals ; Calcium Channels/drug effects ; Cells, Cultured ; Dental Pulp/innervation ; Enkephalin, Ala(2)-MePhe(4)-Gly(5)- ; Enkephalins/*pharmacology ; Male ; Neurons, Afferent/*drug effects/physiology ; Neurotransmitter Agents/metabolism ; Nociceptors/*drug effects/physiology ; Patch-Clamp Techniques ; Presynaptic Terminals/drug effects/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Opioid, mu/*physiology ; Receptors, Somatostatin/physiology ; Sodium Channel Blockers ; Somatostatin/pharmacology
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    Floyd Bloom: the next editor-in-chief of Science (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-03-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lerner, R A -- Guillemin, R -- New York, N.Y. -- Science. 1995 Mar 10;267(5203):1441-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Scripps Research Institute, La Jolla, CA 92037.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7878461" target="_blank"〉PubMed〈/a〉
    Keywords: Administrative Personnel ; History, 20th Century ; Neuropharmacology/history ; *Periodicals as Topic/history ; *Science/history ; United States
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    A morbillivirus that caused fatal disease in horses and humans (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-04-07
    Description: A morbillivirus has been isolated and added to an increasing list of emerging viral diseases. This virus caused an outbreak of fatal respiratory disease in horses and humans. Genetic analyses show it to be only distantly related to the classic morbilliviruses rinderpest, measles, and canine distemper. When seen by electron microscopy, viruses had 10- and 18-nanometer surface projections that gave them a "double-fringed" appearance. The virus induced syncytia that developed in the endothelium of blood vessels, particularly the lungs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murray, K -- Selleck, P -- Hooper, P -- Hyatt, A -- Gould, A -- Gleeson, L -- Westbury, H -- Hiley, L -- Selvey, L -- Rodwell, B -- New York, N.Y. -- Science. 1995 Apr 7;268(5207):94-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉CSIRO Australian Animal Health Laboratory, East Geelong, Victoria.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7701348" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Amino Acid Sequence ; Animals ; Base Sequence ; Cercopithecus aethiops ; Disease Outbreaks/*veterinary ; Female ; Horse Diseases/epidemiology/mortality/*virology ; Horses ; Humans ; Kidney/virology ; Lung/virology ; Male ; Middle Aged ; Molecular Sequence Data ; Morbillivirus/genetics/*isolation & purification ; Morbillivirus Infections/epidemiology/mortality/*veterinary/*virology ; Pregnancy ; Queensland/epidemiology ; Respiratory Tract Infections/veterinary/virology ; Spleen/virology ; Vero Cells ; Virus Cultivation
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    T cell awareness of paternal alloantigens during pregnancy (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-10-27
    Description: During pregnancy a semiallogeneic fetus survives despite the presence of maternal T cells specific for paternally inherited histocompatibility antigens. A mouse transgenic for a T cell receptor recognizing the major histocompatibility (MHC) antigen H-2Kb was used to follow the fate of T cells reactive to paternal alloantigens. In contrast to syngeneic and third-party allogeneic pregnancies, mice bearing a Kb-positive conceptus had reduced numbers of Kb-reactive T cells and accepted Kb-positive tumor grafts. T cell phenotype and responsiveness were restored after delivery. Thus, during pregnancy maternal T cells acquire a transient state of tolerance specific for paternal alloantigens.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tafuri, A -- Alferink, J -- Moller, P -- Hammerling, G J -- Arnold, B -- New York, N.Y. -- Science. 1995 Oct 27;270(5236):630-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Tumor Immunology Program, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7570020" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Fathers ; Female ; Fetus/*immunology ; Graft Rejection ; H-2 Antigens/*immunology ; *Immune Tolerance ; Male ; Mice ; Mice, Inbred C57BL ; Mice, SCID ; Mice, Transgenic ; Neoplasm Transplantation ; Phenotype ; Placenta/immunology ; Pregnancy ; Pregnancy, Animal/*immunology ; Receptors, Antigen, T-Cell/immunology ; T-Lymphocytes/*immunology
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    Thailand weighs AIDS vaccine tests (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-11-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1995 Nov 10;270(5238):904-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7481784" target="_blank"〉PubMed〈/a〉
    Keywords: *AIDS Vaccines/immunology ; Acquired Immunodeficiency Syndrome/*prevention & control ; Animals ; *Clinical Trials as Topic/economics ; Cohort Studies ; Costs and Cost Analysis ; Female ; HIV/classification ; HIV Antibodies/biosynthesis ; *HIV Envelope Protein gp120/immunology ; HIV Infections/*prevention & control ; Humans ; International Cooperation ; Male ; Pan troglodytes ; Patient Selection ; Thailand ; United States
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    AIDS-associated Kaposi's sarcoma (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-02-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jones, J L -- Hanson, D L -- Chu, S Y -- Ward, J W -- Jaffe, H W -- New York, N.Y. -- Science. 1995 Feb 24;267(5201):1078-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7855583" target="_blank"〉PubMed〈/a〉
    Keywords: AIDS-Related Opportunistic Infections/drug therapy/virology ; Acquired Immunodeficiency Syndrome/*complications/drug therapy ; Acyclovir/therapeutic use ; Female ; Foscarnet/*therapeutic use ; Ganciclovir/therapeutic use ; Herpesviridae Infections/drug therapy/virology ; Humans ; Male ; Retrospective Studies ; Risk Factors ; Sarcoma, Kaposi/*complications/drug therapy/virology
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    Differences in HIV strains may underlie disease patterns (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-10-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1995 Oct 6;270(5233):30-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7569947" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Developed Countries ; Developing Countries ; Female ; HIV Infections/epidemiology/transmission/*virology ; HIV-1/classification/growth & development/*pathogenicity ; Humans ; Langerhans Cells/*virology ; Male ; Thailand/epidemiology ; Vagina/virology
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    Share and share alike isn't always the rule in science (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-06-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1995 Jun 23;268(5218):1715-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7792594" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Specimen Banks ; *Crystallography, X-Ray ; Databases, Factual ; *Ethics, Professional ; Interprofessional Relations ; Mice ; *Mice, Knockout ; National Institutes of Health (U.S.) ; Publishing ; Research/*standards ; United States
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    Ethics panel coming together (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-09-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1995 Sep 29;269(5232):1807.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11644753" target="_blank"〉PubMed〈/a〉
    Keywords: *Advisory Committees ; *Bioethical Issues ; *Bioethics ; Federal Government ; Genetics ; Government ; Human Experimentation ; *Public Policy ; United States
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    Neurobiology. Brain center linked to perfect pitch (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-02-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nowak, R -- New York, N.Y. -- Science. 1995 Feb 3;267(5198):616.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7839136" target="_blank"〉PubMed〈/a〉
    Keywords: Female ; *Functional Laterality ; Humans ; Magnetic Resonance Imaging ; Male ; *Music ; *Pitch Discrimination ; Temporal Lobe/*anatomy & histology
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    NAS management of RERF (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-03-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seligman, P J -- New York, N.Y. -- Science. 1995 Mar 24;267(5205):1749-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7741918" target="_blank"〉PubMed〈/a〉
    Keywords: Foundations/*organization & administration ; Government Agencies ; International Cooperation ; Japan ; National Academy of Sciences (U.S.) ; *Radiation Injuries ; United States ; Universities
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    An active National Institute of Mental Health (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-06-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Varmus, H -- New York, N.Y. -- Science. 1995 Jun 23;268(5218):1681.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7792582" target="_blank"〉PubMed〈/a〉
    Keywords: National Institute of Mental Health (U.S.)/economics/*organization & ; administration ; Research Support as Topic ; United States
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    Varmus puts his stamp on NIH (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-11-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1995 Nov 24;270(5240):1288-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7481813" target="_blank"〉PubMed〈/a〉
    Keywords: Administrative Personnel ; Budgets ; History, 20th Century ; National Institutes of Health (U.S.)/economics/*organization & administration ; Research ; Research Support as Topic ; United States
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    NIH funding. The price of compromise (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-09-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1995 Sep 22;269(5231):1662.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7569886" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome ; *Budgets ; Financing, Government ; Humans ; National Institutes of Health (U.S.)/*economics ; *Research Support as Topic ; United States
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  • 78
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    Klausner follows own advice at NCI (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-08-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1995 Aug 18;269(5226):912-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7638609" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome ; Administrative Personnel ; History, 20th Century ; Humans ; National Institutes of Health (U.S.)/*organization & administration ; Neoplasms ; Research ; Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 79
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    NIH escapes the ax--for now (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-07-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1995 Jul 21;269(5222):292-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7618092" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; Financing, Government ; National Institutes of Health (U.S.)/*economics ; Politics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 80
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    R&D budget takes shape in Congress, piece by piece. NIH: the view from the Senate (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-07-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1995 Jul 28;269(5223):471.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7624768" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; Financing, Government ; National Institutes of Health (U.S.)/*economics ; Politics ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 81
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    Scientists named in PCR suit (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-06-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barinaga, M -- New York, N.Y. -- Science. 1995 Jun 2;268(5215):1273-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7761847" target="_blank"〉PubMed〈/a〉
    Keywords: *DNA-Directed DNA Polymerase ; *Patents as Topic ; *Polymerase Chain Reaction ; Taq Polymerase ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 82
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    Women in clinical trials: an FDA perspective (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-08-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sherman, L A -- Temple, R -- Merkatz, R B -- New York, N.Y. -- Science. 1995 Aug 11;269(5225):793-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Drug Evaluation and Research, FDA, Rockville, MD 20857, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7638593" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; *Clinical Trials as Topic ; Drug Approval ; Federal Government ; Female ; *Guidelines as Topic ; Humans ; Male ; Paternalism ; *Patient Selection ; Pregnant Women ; Research Design ; *Research Subjects ; Sex Characteristics ; United States ; *United States Food and Drug Administration
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 83
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    Senate restores NIH funding cut (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-06-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1995 Jun 2;268(5215):1271-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7761845" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; Financing, Government ; National Institutes of Health (U.S.)/*economics ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 84
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    Human genome project. Emphasis turns from mapping to large-scale sequencing (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-06-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1995 Jun 2;268(5215):1270-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7761844" target="_blank"〉PubMed〈/a〉
    Keywords: *Chromosome Mapping/economics ; Financing, Government ; *Genome, Human ; Government Agencies/economics ; *Human Genome Project/economics ; Humans ; National Institutes of Health (U.S.)/economics ; Research Support as Topic ; *Sequence Analysis, DNA/economics ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 85
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    Steroid hormone--and neurotransmitter-induced rat sexual behavior: addendum (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-06-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mani, S K -- Allen, J M -- Clark, J H -- Blaustein, J D -- O'Malley, B W -- New York, N.Y. -- Science. 1995 Jun 30;268(5219):1833.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7604251" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Estradiol/*pharmacology ; Female ; Male ; Neurotransmitter Agents/*physiology ; Rats ; Sexual Behavior, Animal/drug effects/*physiology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 86
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    Women's health research blossoms (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-08-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mann, C -- New York, N.Y. -- Science. 1995 Aug 11;269(5225):766-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7638586" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; Clinical Trials as Topic ; Cultural Characteristics ; Developing Countries ; Female ; Humans ; *Internationality ; Male ; Maternal Health Services ; *Patient Selection ; Poverty ; *Research ; Research Design ; *Research Subjects ; Resource Allocation ; Sex Characteristics ; *Women's Health
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 87
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    Russian chaos breeds diphtheria outbreak (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-03-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maurice, J -- New York, N.Y. -- Science. 1995 Mar 10;267(5203):1416-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7878458" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Child ; Communicable Disease Control ; Diphtheria/*epidemiology/immunology/prevention & control ; Diphtheria Toxoid ; *Disease Outbreaks/prevention & control ; Humans ; Immunization Programs ; Russia/epidemiology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 88
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    KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2 (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-05-12
    Description: A gene from human chromosome 11p11.2 was isolated and was shown to suppress metastasis when introduced into rat AT6.1 prostate cancer cells. Expression of this gene, designated KAI1, was reduced in human cell lines derived from metastatic prostate tumors. KAI1 specifies a protein of 267 amino acids, with four hydrophobic and presumably transmembrane domains and one large extracellular hydrophilic domain with three potential N-glycosylation sites. KAI1 is evolutionarily conserved, is expressed in many human tissues, and encodes a member of a structurally distinct family of leukocyte surface glycoproteins. Decreased expression of this gene may be involved in the malignant progression of prostate and other cancers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dong, J T -- Lamb, P W -- Rinker-Schaeffer, C W -- Vukanovic, J -- Ichikawa, T -- Isaacs, J T -- Barrett, J C -- CA 58236/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1995 May 12;268(5212):884-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC 27709, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7754374" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Antigens, CD/chemistry/*genetics/physiology ; Antigens, CD82 ; Base Sequence ; Biological Evolution ; *Chromosomes, Human, Pair 11 ; Gene Expression ; *Genes, Tumor Suppressor ; Humans ; Male ; Membrane Glycoproteins/chemistry/*genetics/physiology ; Mice ; Mice, SCID ; Molecular Sequence Data ; Neoplasm Metastasis/*genetics ; Prostatic Neoplasms/*genetics/pathology ; *Proto-Oncogene Proteins ; Rats ; Transfection ; Tumor Cells, Cultured
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 89
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    The Devi case and more (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-08-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCutchen, C W -- New York, N.Y. -- Science. 1995 Aug 25;269(5227):1032-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7652542" target="_blank"〉PubMed〈/a〉
    Keywords: *Authorship ; *Plagiarism ; United States ; *United States Office of Research Integrity
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 90
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    Inducible gene targeting in mice (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-09-08
    Description: A method of gene targeting that allows the inducible inactivation of a target gene in mice is presented. The method uses an interferon-responsive promoter to control the expression of Cre recombinase. Here, Cre was used to delete a segment of the DNA polymerase beta gene flanked by IoxP recombinase recognition sites. Deletion was complete in liver and nearly complete in lymphocytes within a few days, whereas partial deletion was obtained in other tissues. This method can be used for the inducible inactivation of any other gene in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kuhn, R -- Schwenk, F -- Aguet, M -- Rajewsky, K -- New York, N.Y. -- Science. 1995 Sep 8;269(5229):1427-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Genetics, University of Cologne, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7660125" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Crosses, Genetic ; DNA Nucleotidyltransferases/genetics ; DNA Polymerase I/genetics ; Female ; *GTP-Binding Proteins ; Gene Targeting/*methods ; Genetic Vectors ; *Integrases ; Interferon-alpha/pharmacology ; Interferon-beta/pharmacology ; Liver/drug effects/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Mice, Transgenic ; Myxovirus Resistance Proteins ; Poly I-C/pharmacology ; Promoter Regions, Genetic ; Proteins/genetics ; Recombination, Genetic ; Sequence Deletion ; *Viral Proteins
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 91
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    Evolution made visible (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-01-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weiner, J -- New York, N.Y. -- Science. 1995 Jan 6;267(5194):30-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7809606" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Birds ; Female ; Fishes ; Genetic Variation ; Male ; Reproduction ; Reproduction, Asexual ; *Selection, Genetic
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 92
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    Patterns of human growth (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-04-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heinrichs, C -- Munson, P J -- Counts, D R -- Cutler, G B Jr -- Baron, J -- New York, N.Y. -- Science. 1995 Apr 21;268(5209):442-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7716552" target="_blank"〉PubMed〈/a〉
    Keywords: Body Height ; Body Weight ; Cephalometry ; Female ; *Growth ; Humans ; Infant ; Kinetics ; Male ; Regression Analysis
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 93
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    Common virulence factors for bacterial pathogenicity in plants and animals (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-06-30
    Description: A Pseudomonas aeruginosa strain (UCBPP-PA14) is infectious both in an Arabidopsis thaliana leaf infiltration model and in a mouse full-thickness skin burn model. UCBPP-PA14 exhibits ecotype specificity for Arabidopsis, causing a range of symptoms from none to severe in four different ecotypes. In the mouse model, UCBPP-PA14 is as lethal as other well-studied P. aeruginosa strains. Mutations in the UCBPP-PA14 toxA, plcS, and gacA genes resulted in a significant reduction in pathogenicity in both hosts, indicating that these genes encode virulence factors required for the full expression of pathogenicity in both plants and animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rahme, L G -- Stevens, E J -- Wolfort, S F -- Shao, J -- Tompkins, R G -- Ausubel, F M -- New York, N.Y. -- Science. 1995 Jun 30;268(5219):1899-902.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Harvard Medical School, Boston, MA 02114, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7604262" target="_blank"〉PubMed〈/a〉
    Keywords: *ADP Ribose Transferases ; Animals ; Arabidopsis/*microbiology ; Bacterial Proteins/genetics ; *Bacterial Toxins ; Base Sequence ; Burns/complications ; Exotoxins/genetics ; Male ; Mice ; Molecular Sequence Data ; Mutation ; Phospholipases/genetics ; Plant Diseases/*microbiology ; Pseudomonas Infections/*microbiology ; Pseudomonas aeruginosa/genetics/growth & development/*pathogenicity ; Virulence/genetics ; *Virulence Factors
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 94
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    Getting a grip on G protein function in C. elegans (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-03-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J -- New York, N.Y. -- Science. 1995 Mar 17;267(5204):1596-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7886445" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal ; Caenorhabditis elegans/genetics/*physiology ; GTP-Binding Proteins/genetics/*physiology ; Genes, Helminth ; Male ; Mutation ; *Signal Transduction
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 95
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    Inactivation of the mouse Huntington's disease gene homolog Hdh (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-07-21
    Description: Huntington's disease (HD) is a dominant neurodegenerative disorder caused by expansion of a CAG repeat in the gene encoding huntingtin, a protein of unknown function. To distinguish between "loss of function" and "gain of function" models of HD, the murine HD homolog Hdh was inactivated by gene targeting. Mice heterozygous for Hdh inactivation were phenotypically normal, whereas homozygosity resulted in embryonic death. Homozygotes displayed abnormal gastrulation at embryonic day 7.5 and were resorbing by day 8.5. Thus, huntingtin is critical early in embryonic development, before the emergence of the nervous system. That Hdh inactivation does not mimic adult HD neuropathology suggests that the human disease involves a gain of function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Duyao, M P -- Auerbach, A B -- Ryan, A -- Persichetti, F -- Barnes, G T -- McNeil, S M -- Ge, P -- Vonsattel, J P -- Gusella, J F -- Joyner, A L -- NS16367/NS/NINDS NIH HHS/ -- NS32765/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1995 Jul 21;269(5222):407-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown 02129, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7618107" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cell Line ; Ectoderm/cytology ; Embryonic and Fetal Development ; Female ; Gene Targeting ; Genotype ; Heterozygote ; Homozygote ; Humans ; Huntington Disease/*genetics ; Male ; Mesoderm/cytology ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; Nerve Tissue Proteins/*genetics/physiology ; Nuclear Proteins/*genetics/physiology ; Phenotype ; Stem Cells/metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 96
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    Participation of the protein Go in multiple aspects of behavior in C. elegans (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-03-17
    Description: The goa-1 gene encoding the alpha subunit of the heterotrimeric guanosine triphosphate-binding protein (G protein) Go from Caenorhabditis elegans is expressed in most neurons, and in the muscles involved in egg laying and male mating. Reduction-of-function mutations in goa-1 caused a variety of behavioral defects including hyperactive movement, premature egg laying, and male impotence. Expression of the activated Go alpha subunit (G alpha o) in transgenic nematodes resulted in lethargic movement, delayed egg laying, and reduced mating efficiency. Induced expression of activated G alpha o in adults was sufficient to cause these phenotypes, indicating that G alpha o mediates behavior through its role in neuronal function and the functioning of specialized muscles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mendel, J E -- Korswagen, H C -- Liu, K S -- Hajdu-Cronin, Y M -- Simon, M I -- Plasterk, R H -- Sternberg, P W -- New York, N.Y. -- Science. 1995 Mar 17;267(5204):1652-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, California Institute of Technology, Pasadena 91125.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7886455" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Animals, Genetically Modified ; Base Sequence ; Behavior, Animal ; Caenorhabditis elegans/genetics/*physiology ; Disorders of Sex Development ; Female ; GTP-Binding Proteins/genetics/*physiology ; Genes, Helminth ; Male ; Molecular Sequence Data ; Movement ; Muscles/innervation/physiology ; Mutation ; Neurons/physiology ; Oviposition ; Phenotype ; Serotonin/pharmacology ; Sexual Behavior, Animal
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 97
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    Detecting Alzheimer's disease (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-03-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- Kumar, S R -- Thach, A B -- Kiat-Winarko, T -- Frambach, D A -- New York, N.Y. -- Science. 1995 Mar 17;267(5204):1577; author reply 1580-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7741897" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Alzheimer Disease/*diagnosis ; Female ; Humans ; Male ; Pupil/*drug effects ; *Tropicamide
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 98
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    The Devi case and more (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-08-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Devi, S J -- New York, N.Y. -- Science. 1995 Aug 25;269(5227):1030.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7652537" target="_blank"〉PubMed〈/a〉
    Keywords: *Authorship ; Cryptococcus neoformans/immunology ; Fungal Vaccines ; National Institutes of Health (U.S.) ; *Publishing ; United States ; United States Office of Research Integrity ; Vaccines, Conjugate
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 99
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    Attenuated retrovirus vaccines and AIDS (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-11-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, P A -- New York, N.Y. -- Science. 1995 Nov 17;270(5239):1219-20; author reply 1220-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7502054" target="_blank"〉PubMed〈/a〉
    Keywords: *AIDS Vaccines ; Animals ; Animals, Newborn ; Female ; HIV Infections/*prevention & control/transmission ; Humans ; Macaca mulatta ; Male ; Simian Immunodeficiency Virus/pathogenicity ; Vaccination ; Vaccines, Attenuated
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 100
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    Thumbs, tools, and early humans (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-04-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hamrick, M W -- Inouye, S E -- New York, N.Y. -- Science. 1995 Apr 28;268(5210):586-7; author reply 589.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7725112" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Biomechanical Phenomena ; Fossils ; Gorilla gorilla/*anatomy & histology ; History, Ancient ; Hominidae/*anatomy & histology ; Humans ; Motor Skills ; Pan troglodytes/anatomy & histology ; Thumb/*anatomy & histology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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