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  • 1
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    Paleomagnetic results from the eastern Caliente-Enterprise zone, southwestern Utah: Implications for initiation of a major Miocene transfer zone (2014)
    Geological Society of America (GSA)
    In: Geosphere
    Details
    Publication Date: 2014-05-29
    Description: The Miocene Caliente-Enterprise zone (CEZ) in southwestern Utah (USA) is a 20–50-km-wide east-northeast–trending left-lateral transfer zone that displaces north-south–trending crustal blocks of the eastern Basin and Range Province to the west. Previous paleomagnetic results from the central and western CEZ show significant counterclockwise vertical axis rotations of strike-slip–bounded fault blocks, and these rotation estimates vary in magnitude both across and along the strike of the zone. Results of recent detailed geologic mapping and new geochronologic data in the area east of previous studies allow us to extend paleomagnetic studies into the easternmost CEZ. New paleomagnetic results include data from 4 regionally extensive latest Oligocene to early Miocene (ca. 24–22 Ma) ignimbrite sheets and from 3 ca. 22–20 Ma Iron Axis laccoliths. These data reveal significant magnitudes and similar spatially variable components of counterclockwise vertical axis rotation. Rotation estimates from the ignimbrites are assessed relative to what we interpret to be a nonrotated to only minimally rotated reference section just north of the Colorado Plateau (Grass Valley) and from several low-extension areas in southeast Nevada. Accepted tilt-corrected paleomagnetic data from sites away from the reference areas are discordant in declination from the expected individual ash-flow tuff directions, with rotation (R) and flattening (F) estimates that range from R = –2° to –84° and F = +15° to –14°. Many of the rotation estimates are large and statistically significant. For example, site P-18 from the Bauers Tuff yields an R = –61.1° ± 5.3° and F = –0.6° ± 5.0°. Relative to the expected Miocene direction, in situ paleomagnetic data from the Iron Axis laccoliths, specifically the Three Peaks laccolith, yield a mean that is discordant in declination, with estimated R = –22.2° and F = –8.8° values. These rotation and flattening estimates, although consistent with the overall data set from volcanic rocks, must be considered of lesser quality, as we are unable to accurately correct these data for possible effects of local tilting. If the rotation estimate is viable, then we suggest that this component of deformation involves much of the upper crust, and we furthermore propose that the boundary of the eastern CEZ extends farther east than previously envisioned, to within a few kilometers of the breakaway with the Colorado Plateau. The transitional zone between the eastern CEZ and Colorado Plateau is therefore abrupt and occurs within a narrow zone near Cedar City, Utah.
    Electronic ISSN: 1553-040X
    Topics: Geosciences
    Published by Geological Society of America (GSA)
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  • 2
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    Direct Observation of Melting in Shock-Compressed Bismuth With Femtosecond X-ray Diffraction (2015)
    American Physical Society (APS)
    Details
    Publication Date: 2015-08-29
    Description: Author(s): M. G. Gorman, R. Briggs, E. E. McBride, A. Higginbotham, B. Arnold, J. H. Eggert, D. E. Fratanduono, E. Galtier, A. E. Lazicki, H. J. Lee, H. P. Liermann, B. Nagler, A. Rothkirch, R. F. Smith, D. C. Swift, G. W. Collins, J. S. Wark, and M. I. McMahon The melting of bismuth in response to shock compression has been studied using in situ femtosecond x-ray diffraction at an x-ray free electron laser. Both solid-solid and solid-liquid phase transitions are documented using changes in discrete diffraction peaks and the emergence of broad, liquid scat… [Phys. Rev. Lett. 115, 095701] Published Fri Aug 28, 2015
    Keywords: Condensed Matter: Structure, etc.
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
    Published by American Physical Society (APS)
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  • 3
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    Potential Reversal and the Effects of Flow Pattern on Galvanic Corrosion of Lead (2012)
    American Chemical Society (ACS)
    Details
    Publication Date: 2012-10-05
    Description: Environmental Science & Technology DOI: 10.1021/es3017396
    Print ISSN: 0013-936X
    Electronic ISSN: 1520-5851
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Published by American Chemical Society (ACS)
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  • 4
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    Control of neonatal tolerance to tissue antigens by peripheral T cell trafficking (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-11-13
    Description: Self tolerance is acquired by the developing immune system. As reported here, particular properties of the neonatal tissue contribute to this process. Neonatal skin, but not adult skin, was accessible for naive CD8 T cells. In mouse bone marrow chimeras generated at different ages, recent thymic emigrants were tolerized to a skin-expressed major histocompatibility complex class I antigen only during a neonatal period but not during adulthood. Blockade of T cell migration neonatally prevented tolerance induction. Thus, T cell trafficking through nonlymphoid tissues in the neonate is crucial for the establishment of self tolerance to sessile, skin-expressed antigens.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alferink, J -- Tafuri, A -- Vestweber, D -- Hallmann, R -- Hammerling, G J -- Arnold, B -- New York, N.Y. -- Science. 1998 Nov 13;282(5392):1338-41.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Tumor Immunology Program, German Cancer Research Center, 69120 Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9812902" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Antigen Presentation ; Bone Marrow Transplantation ; CD8-Positive T-Lymphocytes/*immunology ; Cell Movement ; Graft Rejection ; H-2 Antigens/*immunology ; Keratinocytes/immunology ; Mice ; Mice, Transgenic ; Neoplasm Transplantation ; Neoplasms, Experimental/immunology ; Self Tolerance/*immunology ; Skin/*immunology ; Skin Transplantation ; T-Lymphocytes/*immunology ; Thymus Gland/immunology ; Transplantation Chimera
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Vascular normalization in Rgs5-deficient tumours promotes immune destruction (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-04-18
    Description: The vasculature of solid tumours is morphologically aberrant and characterized by dilated and fragile vessels, intensive vessel sprouting and loss of hierarchical architecture. Constant vessel remodelling leads to spontaneous haemorrhages and increased interstitial fluid pressure in the tumour environment. Tumour-related angiogenesis supports tumour growth and is also a major obstacle for successful immune therapy as it prevents migration of immune effector cells into established tumour parenchyma. The molecular mechanisms for these angiogenic alterations are largely unknown. Here we identify regulator of G-protein signalling 5 (Rgs5) as a master gene responsible for the abnormal tumour vascular morphology in mice. Loss of Rgs5 results in pericyte maturation, vascular normalization and consequent marked reductions in tumour hypoxia and vessel leakiness. These vascular and intratumoral changes enhance influx of immune effector cells into tumour parenchyma and markedly prolong survival of tumour-bearing mice. This is the first demonstration, to our knowledge, of reduced tumour angiogenesis and improved immune therapeutic outcome on loss of a vascular gene function and establishes a previously unrecognized role of G-protein signalling in tumour angiogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hamzah, Juliana -- Jugold, Manfred -- Kiessling, Fabian -- Rigby, Paul -- Manzur, Mitali -- Marti, Hugo H -- Rabie, Tamer -- Kaden, Sylvia -- Grone, Hermann-Josef -- Hammerling, Gunter J -- Arnold, Bernd -- Ganss, Ruth -- England -- Nature. 2008 May 15;453(7193):410-4. doi: 10.1038/nature06868. Epub 2008 Apr 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Western Australian Institute for Medical Research, UWA Centre for Medical Research, Perth, Western Australia 6000, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18418378" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Capillary Permeability ; Cell Hypoxia/physiology ; Female ; Male ; Mice ; Neovascularization, Pathologic/*prevention & control ; Oxygen/metabolism ; Pancreatic Neoplasms/*blood supply/genetics/*immunology/metabolism ; RGS Proteins/*deficiency/genetics/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 6
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    A plant miRNA contributes to antibacterial resistance by repressing auxin signaling (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-04-22
    Description: Plants and animals activate defenses after perceiving pathogen-associated molecular patterns (PAMPs) such as bacterial flagellin. In Arabidopsis, perception of flagellin increases resistance to the bacterium Pseudomonas syringae, although the molecular mechanisms involved remain elusive. Here, we show that a flagellin-derived peptide induces a plant microRNA (miRNA) that negatively regulates messenger RNAs for the F-box auxin receptors TIR1, AFB2, and AFB3. Repression of auxin signaling restricts P. syringae growth, implicating auxin in disease susceptibility and miRNA-mediated suppression of auxin signaling in resistance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Navarro, Lionel -- Dunoyer, Patrice -- Jay, Florence -- Arnold, Benedict -- Dharmasiri, Nihal -- Estelle, Mark -- Voinnet, Olivier -- Jones, Jonathan D G -- New York, N.Y. -- Science. 2006 Apr 21;312(5772):436-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16627744" target="_blank"〉PubMed〈/a〉
    Keywords: Arabidopsis/genetics/immunology/*metabolism/*microbiology ; Arabidopsis Proteins/genetics/metabolism ; Down-Regulation ; F-Box Proteins/genetics/metabolism ; Flagellin/metabolism ; Gene Expression Regulation, Plant ; Indoleacetic Acids/*metabolism ; MicroRNAs/*physiology ; Plant Diseases/microbiology ; Plants, Genetically Modified ; Pseudomonas syringae/growth & development/*pathogenicity ; RNA, Messenger/genetics/metabolism ; RNA, Plant/physiology ; Receptors, Cell Surface/genetics/metabolism ; Recombinant Fusion Proteins/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; *Signal Transduction ; Transformation, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Discs large 1 controls daughter-cell polarity after cytokinesis in vertebrate morphogenesis [Cell Biology] (2018)
    National Academy of Sciences
    Details
    Publication Date: 2018-11-14
    Description: Vertebrate embryogenesis and organogenesis are driven by cell biological processes, ranging from mitosis and migration to changes in cell size and polarity, but their control and causal relationships are not fully defined. Here, we use the developing limb skeleton to better define the relationships between mitosis and cell polarity. We...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 8
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    T cell awareness of paternal alloantigens during pregnancy (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-10-27
    Description: During pregnancy a semiallogeneic fetus survives despite the presence of maternal T cells specific for paternally inherited histocompatibility antigens. A mouse transgenic for a T cell receptor recognizing the major histocompatibility (MHC) antigen H-2Kb was used to follow the fate of T cells reactive to paternal alloantigens. In contrast to syngeneic and third-party allogeneic pregnancies, mice bearing a Kb-positive conceptus had reduced numbers of Kb-reactive T cells and accepted Kb-positive tumor grafts. T cell phenotype and responsiveness were restored after delivery. Thus, during pregnancy maternal T cells acquire a transient state of tolerance specific for paternal alloantigens.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tafuri, A -- Alferink, J -- Moller, P -- Hammerling, G J -- Arnold, B -- New York, N.Y. -- Science. 1995 Oct 27;270(5236):630-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Tumor Immunology Program, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7570020" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Fathers ; Female ; Fetus/*immunology ; Graft Rejection ; H-2 Antigens/*immunology ; *Immune Tolerance ; Male ; Mice ; Mice, Inbred C57BL ; Mice, SCID ; Mice, Transgenic ; Neoplasm Transplantation ; Phenotype ; Placenta/immunology ; Pregnancy ; Pregnancy, Animal/*immunology ; Receptors, Antigen, T-Cell/immunology ; T-Lymphocytes/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Subthreshold laser jetting via flow-focusing in laser-induced forward transfer (2018)
    American Physical Society (APS)
    Details
    Publication Date: 2018-08-16
    Description: Author(s): Emre Turkoz, SeungYeon Kang, Luc Deike, and Craig B. Arnold The process of blister-actuated laser-induced forward transfer (BA-LIFT) results in focused jets which are thinner and faster than regular jets. [Phys. Rev. Fluids 3, 082201(R)] Published Wed Aug 15, 2018
    Keywords: Micro- and Nanofluidics
    Electronic ISSN: 2469-990X
    Topics: Physics
    Published by American Physical Society (APS)
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  • 10
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    Levels of peripheral T cell tolerance induced by different doses of tolerogen (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-02-04
    Description: Antigen-specific immunosuppression requires an understanding of the parameters that control peripheral T cell tolerance. A liver-specific inducible promoter was used to drive the expression of the major histocompatibility complex antigen Kb in transgenic mice. Minute amounts of Kb, expressed exclusively on hepatocytes, induced tolerance by partial down-regulation of the T cell receptor (TCR) on the self-reactive CD8+ cells. Contact of these tolerant T cells with high concentrations of Kb after induction led to complete down-regulation of TCR. Thus, tolerant T cells are susceptible to further tolerogenic signals and reach different levels of tolerance depending on antigen dose.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ferber, I -- Schonrich, G -- Schenkel, J -- Mellor, A L -- Hammerling, G J -- Arnold, B -- New York, N.Y. -- Science. 1994 Feb 4;263(5147):674-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Somatic Genetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8303275" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Ly/analysis ; C-Reactive Protein/genetics ; Dose-Response Relationship, Immunologic ; Down-Regulation ; H-2 Antigens/genetics/*immunology ; Immune Tolerance/*immunology ; Lipopolysaccharides/immunology ; Liver/*immunology ; Mice ; Mice, Inbred CBA ; Mice, Transgenic ; Promoter Regions, Genetic ; Receptors, Antigen, T-Cell/genetics/immunology ; T-Lymphocytes/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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