Publication Date:
1998-11-13
Description:
Self tolerance is acquired by the developing immune system. As reported here, particular properties of the neonatal tissue contribute to this process. Neonatal skin, but not adult skin, was accessible for naive CD8 T cells. In mouse bone marrow chimeras generated at different ages, recent thymic emigrants were tolerized to a skin-expressed major histocompatibility complex class I antigen only during a neonatal period but not during adulthood. Blockade of T cell migration neonatally prevented tolerance induction. Thus, T cell trafficking through nonlymphoid tissues in the neonate is crucial for the establishment of self tolerance to sessile, skin-expressed antigens.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alferink, J -- Tafuri, A -- Vestweber, D -- Hallmann, R -- Hammerling, G J -- Arnold, B -- New York, N.Y. -- Science. 1998 Nov 13;282(5392):1338-41.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Tumor Immunology Program, German Cancer Research Center, 69120 Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9812902" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Animals, Newborn
;
Antigen Presentation
;
Bone Marrow Transplantation
;
CD8-Positive T-Lymphocytes/*immunology
;
Cell Movement
;
Graft Rejection
;
H-2 Antigens/*immunology
;
Keratinocytes/immunology
;
Mice
;
Mice, Transgenic
;
Neoplasm Transplantation
;
Neoplasms, Experimental/immunology
;
Self Tolerance/*immunology
;
Skin/*immunology
;
Skin Transplantation
;
T-Lymphocytes/*immunology
;
Thymus Gland/immunology
;
Transplantation Chimera
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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