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  • 1
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    MOA-2011-BLG-322Lb: a 'second generation survey' microlensing planet (2014)
    Oxford University Press
    Details
    Publication Date: 2014-03-01
    Description: Global ‘second-generation’ microlensing surveys aim to discover and characterize extrasolar planets and their frequency, by means of round-the-clock high-cadence monitoring of a large area of the Galactic bulge, in a controlled experiment. We report the discovery of a giant planet in microlensing event MOA-2011-BLG-322. This moderate-magnification event, which displays a clear anomaly induced by a second lensing mass, was inside the footprint of our second-generation microlensing survey, involving MOA, OGLE and the Wise Observatory. The event was observed by the survey groups, without prompting alerts that could have led to dedicated follow-up observations. Fitting a microlensing model to the data, we find that the time-scale of the event was t E  = 23.2 ± 0.8 d, and the mass ratio between the lens star and its companion is q  = 0.028 ± 0.001. Finite-source effects are marginally detected, and upper limits on them help break some of the degeneracy in the system parameters. Using a Bayesian analysis that incorporates a Galactic structure model, we estimate the mass of the lens at $0.39^{+0.45}_{-0.19}\,{\rm M}_{\odot }$ , at a distance of 7.56 ± 0.91 kpc. Thus, the companion is likely a planet of mass $11.6^{+13.4}_{-5.6}\, M_{\rm J}$ , at a projected separation of $4.3^{+1.5}_{-1.2}$ au , rather far beyond the snow line. This is the first pure-survey planet reported from a second-generation microlensing survey, and shows that survey data alone can be sufficient to characterize a planetary model. With the detection of additional survey-only planets, we will be able to constrain the frequency of extrasolar planets near their systems’ snow lines.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 2
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    Climate change and water resources in a tropical island system: propagation of uncertainty from statistically downscaled climate models to hydrologic models (2015)
    Wiley
    Details
    Publication Date: 2015-12-16
    Description: ABSTRACT Many tropical islands have limited water resources with historically increasing demand, all potentially affected by a changing climate. The effects of climate change on island hydrology are difficult to model due to steep local precipitation gradients and sparse data. This work uses 10 statistically downscaled general circulation models (GCMs) under two greenhouse gas emission scenarios to evaluate the uncertainty propagated from GCMs in projecting the effects of climate change on water resources in a tropical island system. The assessment is conducted using a previously configured hydrologic model, the Precipitation Runoff Modelling System (PRMS) for Puerto Rico. Projected climate data and their modelled hydrologic variables versus historical measurements and their modelled hydrologic variables are found to have empirical distribution functions that are statistically different with less than 1 year of daily data aggregation. Thus, only annual averages of the projected hydrologic variables are employed as completely bias-corrected model outputs. The magnitude of the projected total flow decreases in the four regions covering Puerto Rico, but with a large range of uncertainty depending on the makeup of the GCM ensemble. The multi-model mean projected total flow decreases by 49–88% of historical amounts from the 1960s to the 2090s for the high emissions scenarios and by 39–79% for the low emissions scenarios. Subsurface flow contributions decreased the least and groundwater flow contributions decreased the most across the island. At locations critical to water supply for human use, projected streamflow is shown to decrease substantially below projected withdrawals by 2099.
    Print ISSN: 0899-8418
    Electronic ISSN: 1097-0088
    Topics: Geosciences , Physics
    Published by Wiley
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  • 3
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    Genome-wide impact of a recently expanded microRNA cluster in mouse [Biophysics and Computational Biology] (2011)
    National Academy of Sciences
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    Publication Date: 2011-09-21
    Description: Variations in microRNA (miRNA) gene and/or target repertoire are likely to be key drivers of phenotypic differences between species. To better understand these changes, we developed a computational method that identifies signatures of species-specific target site gain and loss associated with miRNA acquisition. Interestingly, several of the miRNAs implicated in mouse 3′ UTR evolution derive from a single rapidly expanded rodent-specific miRNA cluster. Located in the intron of Sfmbt2, a maternally imprinted polycomb gene, these miRNAs (referred to as the Sfmbt2 cluster) are expressed in both embryonic stem cells and the placenta. One abundant miRNA from the cluster, miR-467a, functionally overlaps with the mir-290-295 cluster in promoting growth and survival of mouse embryonic stem cells. Predicted novel targets of the remaining cluster members are enriched in pathways regulating cell survival. Two relevant species-specific target candidates, Lats2 and Dedd2, were validated in cultured cells. We suggest that the rapid evolution of the Sfmbt2 cluster may be a result of intersex conflict for growth regulation in early mammalian development and could provide a general model for the genomic response to acquisition of miRNAs and similar regulatory factors.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 4
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    Extensive Horizontal Gene Transfer during Staphylococcus aureus Co-colonization In Vivo (2014)
    Oxford University Press
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    Publication Date: 2014-10-12
    Description: Staphylococcus aureus is a commensal and major pathogen of humans and animals. Comparative genomics of S. aureus populations suggests that colonization of different host species is associated with carriage of mobile genetic elements (MGE), particularly bacteriophages and plasmids capable of encoding virulence, resistance, and immune evasion pathways. Antimicrobial-resistant S. aureus of livestock are a potential zoonotic threat to human health if they adapt to colonize humans efficiently. We utilized the technique of experimental evolution and co-colonized gnotobiotic piglets with both human- and pig-associated variants of the lineage clonal complex 398, and investigated growth and genetic changes over 16 days using whole genome sequencing. The human isolate survived co-colonization on piglets more efficiently than in vitro. During co-colonization, transfer of MGE from the pig to the human isolate was detected within 4 h. Extensive and repeated transfer of two bacteriophages and three plasmids resulted in colonization with isolates carrying a wide variety of mobilomes. Whole genome sequencing of progeny bacteria revealed no acquisition of core genome polymorphisms, highlighting the importance of MGE. Staphylococcus aureus bacteriophage recombination and integration into novel sites was detected experimentally for the first time. During colonization, clones coexisted and diversified rather than a single variant dominating. Unexpectedly, each piglet carried unique populations of bacterial variants, suggesting limited transmission of bacteria between piglets once colonized. Our data show that horizontal gene transfer occurs at very high frequency in vivo and significantly higher than that detectable in vitro.
    Electronic ISSN: 1759-6653
    Topics: Biology
    Published by Oxford University Press
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  • 5
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    Sphalerite catalyzes C-H bond activation [Earth, Atmospheric, and Planetary Sciences] (2014)
    National Academy of Sciences
    Details
    Publication Date: 2014-08-13
    Description: Reactions among minerals and organic compounds in hydrothermal systems are critical components of the Earth’s deep carbon cycle, provide energy for the deep biosphere, and may have implications for the origins of life. However, there is limited information as to how specific minerals influence the reactivity of organic compounds. Here...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 6
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    Imaging and manipulating molecules on a zeolite surface with an atomic force microscope (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-03-16
    Description: The adsorption of neutral molecules and ions on the surfaces of zeolites was observed in real time with an atomic force microscope (AFM). Direct imaging of the surface of the zeolite clinoptilolite was possible by using a diluted tert-butyl ammonium chloride solution as a medium. Images of the crystal in different liquids revealed that molecules could be bound to the surface in different ways; neutral molecules of tert-butanol formed an ordered array, whereas tert-butyl ammonium ions formed clusters. These absorbed molecules were not rearranged by the AFM tip when used in an imaging mode. However, when a sufficiently large force was applied, the tip of the AFM could rearrange the tert-butyl ammonium ions on the zeolite surface. This demonstration of molecular manipulation suggests new applications, including biosensors and lithography.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weisenhorn, A L -- Mac Dougall, J E -- Gould, S A -- Cox, S D -- Wise, W S -- Massie, J -- Maivald, P -- Elings, V B -- Stucky, G D -- Hansma, P K -- New York, N.Y. -- Science. 1990 Mar 16;247(4948):1330-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17843797" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    The scanning ion-conductance microscope (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-02-03
    Description: A scanning ion-conductance microscope (SICM) has been developed that can image the topography of nonconducting surfaces that are covered with electrolytes. The probe of the SICM is an electrolyte-filled micropipette. The flow of ions through the opening of the pipette is blocked at short distances between the probe and the surface, thus, limiting the ion conductance. A feedback mechanism can be used to maintain a given conductance and in turn determine the distance to the surface. The SICM can also sample and image the local ion currents above the surfaces. To illustrate its potential for imaging ion currents through channels in membranes, a topographic image of a membrane filter with 0.80-micrometer pores and an image of the ion currents flowing through such pores are presented.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hansma, P K -- Drake, B -- Marti, O -- Gould, S A -- Prater, C B -- New York, N.Y. -- Science. 1989 Feb 3;243(4891):641-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, University of California, Santa Barbara 93106.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2464851" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Membrane/ultrastructure ; Electric Conductivity ; Electrodes ; Ion Channels/metabolism ; *Ions ; Microscopy/*instrumentation ; Solutions
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-05-01
    Description: Germ-line mutations of the APC gene are responsible for familial adenomatous polyposis (FAP), an autosomal dominantly inherited disease in humans. Patients with FAP develop multiple benign colorectal tumors. Recently, a mouse lineage that exhibits an autosomal dominantly inherited predisposition to multiple intestinal neoplasia (Min) was described. Linkage analysis showed that the murine homolog of the APC gene (mApc) was tightly linked to the Min locus. Sequence comparison of mApc between normal and Min-affected mice identified a nonsense mutation, which cosegregated with the Min phenotype. This mutation is analogous to those found in FAP kindreds and in sporadic colorectal cancers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Su, L K -- Kinzler, K W -- Vogelstein, B -- Preisinger, A C -- Moser, A R -- Luongo, C -- Gould, K A -- Dove, W F -- CA-06973/CA/NCI NIH HHS/ -- CA-07175/CA/NCI NIH HHS/ -- CA-23076/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1992 May 1;256(5057):668-70.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Genetics Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21231.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1350108" target="_blank"〉PubMed〈/a〉
    Keywords: Adenomatous Polyposis Coli/*genetics ; Animals ; Base Sequence ; Blotting, Southern ; Colorectal Neoplasms/genetics ; DNA, Neoplasm/chemistry/genetics ; *Genes, Tumor Suppressor ; Genetic Linkage ; Humans ; Intestinal Neoplasms/*genetics ; Mice ; Mice, Inbred AKR ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Molecular Sequence Data ; *Mutation ; Phenotype ; Polymorphism, Restriction Fragment Length ; Sequence Homology, Nucleic Acid
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Discovery of a Jupiter/Saturn analog with gravitational microlensing (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-02-16
    Description: Searches for extrasolar planets have uncovered an astonishing diversity of planetary systems, yet the frequency of solar system analogs remains unknown. The gravitational microlensing planet search method is potentially sensitive to multiple-planet systems containing analogs of all the solar system planets except Mercury. We report the detection of a multiple-planet system with microlensing. We identify two planets with masses of approximately 0.71 and approximately 0.27 times the mass of Jupiter and orbital separations of approximately 2.3 and approximately 4.6 astronomical units orbiting a primary star of mass approximately 0.50 solar mass at a distance of approximately 1.5 kiloparsecs. This system resembles a scaled version of our solar system in that the mass ratio, separation ratio, and equilibrium temperatures of the planets are similar to those of Jupiter and Saturn. These planets could not have been detected with other techniques; their discovery from only six confirmed microlensing planet detections suggests that solar system analogs may be common.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gaudi, B S -- Bennett, D P -- Udalski, A -- Gould, A -- Christie, G W -- Maoz, D -- Dong, S -- McCormick, J -- Szymanski, M K -- Tristram, P J -- Nikolaev, S -- Paczynski, B -- Kubiak, M -- Pietrzynski, G -- Soszynski, I -- Szewczyk, O -- Ulaczyk, K -- Wyrzykowski, L -- OGLE Collaboration -- Depoy, D L -- Han, C -- Kaspi, S -- Lee, C-U -- Mallia, F -- Natusch, T -- Pogge, R W -- Park, B-G -- MuFUN Collaboration -- Abe, F -- Bond, I A -- Botzler, C S -- Fukui, A -- Hearnshaw, J B -- Itow, Y -- Kamiya, K -- Korpela, A V -- Kilmartin, P M -- Lin, W -- Masuda, K -- Matsubara, Y -- Motomura, M -- Muraki, Y -- Nakamura, S -- Okumura, T -- Ohnishi, K -- Rattenbury, N J -- Sako, T -- Saito, To -- Sato, S -- Skuljan, L -- Sullivan, D J -- Sumi, T -- Sweatman, W L -- Yock, P C M -- MOA Collaboration -- Albrow, M D -- Allan, A -- Beaulieu, J-P -- Burgdorf, M J -- Cook, K H -- Coutures, C -- Dominik, M -- Dieters, S -- Fouque, P -- Greenhill, J -- Horne, K -- Steele, I -- Tsapras, Y -- PLANET and RoboNet Collaborations -- Chaboyer, B -- Crocker, A -- Frank, S -- Macintosh, B -- New York, N.Y. -- Science. 2008 Feb 15;319(5865):927-30. doi: 10.1126/science.1151947.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Astronomy, Ohio State University, 140 West 18th Avenue, Columbus, OH 43210, USA. gaudi@astronomy.ohio-state.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18276883" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Kepler planet-detection mission: introduction and first results (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-01-09
    Description: The Kepler mission was designed to determine the frequency of Earth-sized planets in and near the habitable zone of Sun-like stars. The habitable zone is the region where planetary temperatures are suitable for water to exist on a planet's surface. During the first 6 weeks of observations, Kepler monitored 156,000 stars, and five new exoplanets with sizes between 0.37 and 1.6 Jupiter radii and orbital periods from 3.2 to 4.9 days were discovered. The density of the Neptune-sized Kepler-4b is similar to that of Neptune and GJ 436b, even though the irradiation level is 800,000 times higher. Kepler-7b is one of the lowest-density planets (approximately 0.17 gram per cubic centimeter) yet detected. Kepler-5b, -6b, and -8b confirm the existence of planets with densities lower than those predicted for gas giant planets.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Borucki, William J -- Koch, David -- Basri, Gibor -- Batalha, Natalie -- Brown, Timothy -- Caldwell, Douglas -- Caldwell, John -- Christensen-Dalsgaard, Jorgen -- Cochran, William D -- DeVore, Edna -- Dunham, Edward W -- Dupree, Andrea K -- Gautier, Thomas N 3rd -- Geary, John C -- Gilliland, Ronald -- Gould, Alan -- Howell, Steve B -- Jenkins, Jon M -- Kondo, Yoji -- Latham, David W -- Marcy, Geoffrey W -- Meibom, Soren -- Kjeldsen, Hans -- Lissauer, Jack J -- Monet, David G -- Morrison, David -- Sasselov, Dimitar -- Tarter, Jill -- Boss, Alan -- Brownlee, Don -- Owen, Toby -- Buzasi, Derek -- Charbonneau, David -- Doyle, Laurance -- Fortney, Jonathan -- Ford, Eric B -- Holman, Matthew J -- Seager, Sara -- Steffen, Jason H -- Welsh, William F -- Rowe, Jason -- Anderson, Howard -- Buchhave, Lars -- Ciardi, David -- Walkowicz, Lucianne -- Sherry, William -- Horch, Elliott -- Isaacson, Howard -- Everett, Mark E -- Fischer, Debra -- Torres, Guillermo -- Johnson, John Asher -- Endl, Michael -- MacQueen, Phillip -- Bryson, Stephen T -- Dotson, Jessie -- Haas, Michael -- Kolodziejczak, Jeffrey -- Van Cleve, Jeffrey -- Chandrasekaran, Hema -- Twicken, Joseph D -- Quintana, Elisa V -- Clarke, Bruce D -- Allen, Christopher -- Li, Jie -- Wu, Haley -- Tenenbaum, Peter -- Verner, Ekaterina -- Bruhweiler, Frederick -- Barnes, Jason -- Prsa, Andrej -- New York, N.Y. -- Science. 2010 Feb 19;327(5968):977-80. doi: 10.1126/science.1185402. Epub 2010 Jan 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉NASA Ames Research Center, Moffett Field, CA 94035, USA. William.J.Borucki@nasa.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20056856" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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