Publikationsdatum:
1994-01-07
Beschreibung:
A recently defined family of cytokines, consisting of ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), and interleukin-6 (IL-6), utilize the Jak-Tyk family of cytoplasmic tyrosine kinases. The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. Activation of these kinases occurs as a result of ligand-induced dimerization of the receptor beta components. Unlike other cytokine receptors studied to date, the receptors for the CNTF cytokine family utilize all known members of the Jak-Tyk family, but induce distinct patterns of Jak-Tyk phosphorylation in different cell lines.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stahl, N -- Boulton, T G -- Farruggella, T -- Ip, N Y -- Davis, S -- Witthuhn, B A -- Quelle, F W -- Silvennoinen, O -- Barbieri, G -- Pellegrini, S -- P30 CA21765/CA/NCI NIH HHS/ -- R01 DK42932/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1994 Jan 7;263(5143):92-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8272873" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Animals
;
*Antigens, CD
;
Cell Line
;
Ciliary Neurotrophic Factor
;
Cytokine Receptor gp130
;
Cytokines/metabolism/*pharmacology
;
Enzyme Activation
;
*Growth Inhibitors
;
*Interleukin-6
;
Janus Kinase 1
;
Janus Kinase 2
;
Leukemia Inhibitory Factor
;
*Lymphokines
;
Membrane Glycoproteins/*metabolism
;
Nerve Tissue Proteins/metabolism/pharmacology
;
Oncostatin M
;
Peptides/metabolism/pharmacology
;
Phosphorylation
;
Protein-Tyrosine Kinases/*metabolism
;
Proteins/metabolism
;
*Proto-Oncogene Proteins
;
Receptor, Ciliary Neurotrophic Factor
;
Receptors, Cytokine/*metabolism
;
Receptors, Growth Factor/metabolism
;
Receptors, Interleukin/metabolism
;
Receptors, Interleukin-6
;
Receptors, OSM-LIF
;
Receptors, Oncostatin M
;
Tyrosine/metabolism
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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